Hub : Genes

CC2D2A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1410	0.0620	8.6e-03	-0.002	NA	-0.005	NA	-0.003	4.2e-01	NA	8.6e-01	NA	5.5e-01
2	GTEx	Testis	0.1370	0.0550	5.3e-03	0.023	NA	0.062	NA	0.032	3.1e-02	NA	9.7e-04	NA	1.4e-02
3	NTR	Blood	0.0322	0.0106	1.3e-04	0.007	0.015	0.013	0.015	0.012	2.0e-03	7.5e-06	2.8e-05	8.5e-06	4.9e-05
4	ROSMAP	Brain Pre-frontal Cortex	0.1497	0.0332	8.6e-12	0.141	0.102	0.122	0.127	0.132	9.7e-18	5.4e-13	2.0e-15	4.6e-16	1.1e-16
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0508	0.0266	3.8e-03	-0.001	0.020	0.007	NA	-0.001	4.9e-01	2.4e-03	4.4e-02	NA	4.0e-01
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0585	0.0262	9.4e-04	0.011	0.024	0.005	NA	0.014	1.7e-02	9.7e-04	8.5e-02	NA	8.4e-03
7	TCGA	Brain Lower Grade Glioma	0.0925	0.0382	1.2e-06	0.070	0.058	0.057	NA	0.063	2.2e-08	3.4e-07	4.9e-07	NA	1.0e-07
8	TCGA	Thyroid Carcinoma	0.0360	0.0190	5.2e-03	0.004	0.005	-0.002	NA	-0.002	1.1e-01	9.9e-02	7.3e-01	NA	5.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	0.1	0.2	0.4	0.2	0.1	-0.3	0.7	-0.5	-0.4	0.7	0.5
Bipolar Disorder or Schizophrenia	0.1	0.2	0.9	-0.2	0.3	0.6	0.5	0.5	-0.2	0.9	0.2
Depressed Affect (Nagel 2018)	4.2	8.8	21.3	-2.9	-4.6	-1.8	-2.0	2.4	4.1	-1.8	-2.7
Depression (Nagel 2018)	4.7	7.1	13.5	-2.7	-3.3	-2.4	-2.2	2.0	3.7	-2.0	-2.5
Intelligence (Savage-Jansen 2018)	0.5	1.6	5.2	2.3	1.1	0.2	1.2	-2.1	-0.6	0.3	0.3
Neuroticism (Nagel 2018)	6.2	14.5	32.0	-3.8	-5.7	-2.8	-3.2	2.4	4.6	-3.2	-3.8
Schizophrenia (2018)	0.2	0.4	1.1	-0.4	0.3	1.1	0.1	1.0	0.0	0.7	-0.1
Schizophrenia vs Biploar Disorder	0.5	0.6	3.6	0.1	0.1	1.9	0.1	-0.1	0.9	0.2	-0.7
Worry (Nagel 2018)	2.0	4.2	8.8	-1.9	-2.8	-1.1	-1.7	1.6	3.0	-1.6	-2.1
Alzheimer’s Disease (in mother)	2.2	2.6	7.8	0.4	0.1	0.0	1.2	2.8	2.5	1.8	1.5
Alzheimer’s Disease (in father)	0.7	0.8	2.5	0.7	1.2	1.6	0.8	-0.2	-0.2	0.9	0.6
Alzheimer’s Disease (including proxy)	0.7	1.0	2.4	-0.3	0.4	0.7	0.7	1.6	1.0	1.3	1.3
Crohns Disease (2017)	1.3	2.8	4.2	-1.3	-2.0	-1.6	-1.8	0.3	2.0	-1.6	-2.0
Irritable Bowel Disease (IBD)	0.6	1.4	3.8	-0.8	-1.0	-0.5	-1.3	-1.4	0.5	-1.2	-2.0
Ulcerative Colitis (UC)	0.7	1.4	5.4	0.6	1.1	0.6	0.6	-2.3	-1.7	0.5	0.1
Major Depression (MDD)	3.3	4.1	8.8	-3.0	-2.8	0.2	-1.9	-0.5	1.3	-1.8	-2.7
Reaction Time	0.7	1.4	3.7	-1.7	-1.9	-0.9	-1.1	1.4	0.2	-0.6	-0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.9	1.3	0.0	-0.1	-0.5	-1.7	0.1	-1.4	-1.5
Breast Cancer	0.5	1.1	3.1	1.1	1.0	1.1	0.6	1.0	-0.3	0.7	1.8
Ovarian Cancer	0.8	1.1	3.9	-0.9	-0.1	0.5	-0.8	-1.4	-2.0	-1.0	0.0
Prostate Cancer	0.3	0.4	1.2	-0.1	0.1	1.1	0.2	0.0	-0.9	0.1	1.0
Age at First Birth	0.8	1.2	4.5	1.3	0.4	0.1	0.0	-2.1	-1.0	-1.0	-1.1
Bipolar Disorder (2011)	0.5	0.5	0.9	0.5	0.2	0.6	0.7	1.0	0.7	0.8	0.9
Body Mass Index (BMI) (2010)	0.7	0.9	3.1	0.6	1.6	1.8	0.3	0.4	-0.6	0.4	0.8
Coronary Artery Disease (CAD)	0.6	0.7	2.0	-1.3	-1.4	-0.4	-0.7	-0.6	-0.3	-0.6	-0.9
Crohns Disease (2012)	1.1	1.7	4.4	-1.0	-1.6	-1.2	-0.9	1.9	2.1	-0.4	-0.4
Mean Putamen Volume	0.8	0.9	3.8	0.0	-0.4	-0.3	0.0	1.8	1.9	0.1	0.1
Fasting Glucose	0.3	0.3	1.1	-0.7	-0.3	-1.0	-0.4	-0.5	-0.4	-0.5	-0.5
HbA1C	1.2	1.3	2.6	-1.0	-0.8	-1.6	-1.4	-0.0	0.6	-1.2	-1.5
HDL Cholesterol	0.1	0.2	0.7	0.2	-0.0	-0.7	0.7	-0.2	-0.0	0.8	0.4
LDL Cholesterol	0.5	0.7	1.5	0.6	1.2	0.8	0.6	-0.9	-1.0	0.7	0.7
Lupus	0.4	0.6	1.2	0.3	1.0	-0.6	0.8	0.1	-1.1	0.7	0.9
Neuroticism (2016)	3.2	4.7	7.9	-2.2	-2.1	-0.9	-2.5	0.4	2.8	-2.5	-2.7
Primary Biliary Cirrhosis	0.4	0.5	1.8	-1.3	-0.4	0.7	-0.6	-0.6	-0.6	-0.7	-0.3
Rheumatoid Arthritis	0.6	0.9	2.9	-0.2	0.5	1.7	-0.2	-1.5	-0.7	-0.2	-1.0
Schizophrenia (2014)	0.1	0.3	1.0	-0.5	0.2	1.0	-0.2	0.6	0.5	0.3	-0.7
Triglycerides	0.2	0.3	1.1	0.1	1.0	0.1	-0.0	0.8	-0.0	0.3	0.6
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.5	0.5	0.9	-0.0	0.4	-1.0	-1.2	-0.0	0.3
Ulcerative Colitis	0.8	1.2	6.9	0.3	-0.3	0.1	-0.3	-2.6	-0.7	-0.6	-1.2
Blood Eosinophil Count	0.4	3.3	15.4	-0.7	-1.6	-3.9	-0.6	0.9	2.3	-0.6	-1.0
Blood Platelet Count	0.0	0.3	1.3	-0.6	-0.7	-1.1	0.2	0.3	0.6	0.1	-0.0
Blood Red Count	2.1	20.5	40.1	-4.5	-4.8	-5.0	-4.7	-2.9	1.8	-4.7	-6.3
Blood White Count	0.5	3.8	7.2	-2.7	-2.1	-1.9	-1.9	-1.5	-0.1	-2.1	-2.3
Heel T-Score	0.3	2.5	4.9	1.4	1.5	1.2	1.9	1.4	1.3	2.2	1.7
BMI	0.4	2.4	6.4	1.1	0.8	1.0	2.5	-0.5	-0.7	2.5	1.5
Height	0.1	1.8	5.4	-0.3	-1.6	-0.9	-0.3	-1.4	1.6	-0.7	-2.3
Waist Hip Ratio (WHR)	3.0	13.4	36.9	-6.1	-5.0	0.4	-4.1	-0.8	-0.6	-3.8	-3.5
Systolic Blood Pressure	0.2	1.2	5.8	-2.4	-1.1	-0.7	-1.0	-0.3	-1.1	-0.7	-0.1
Smoking Status	3.0	7.2	12.5	-3.4	-3.0	-1.2	-3.5	1.9	2.1	-3.1	-2.4
Allergy or Eczema	0.4	1.0	3.2	0.8	1.0	-0.6	0.9	1.2	0.1	0.9	1.8
Cardiovascular Disease	0.6	2.0	3.4	-1.8	-1.3	-0.1	-1.4	-1.6	-1.6	-1.6	-1.1
Hypothyroidism (self reported)	0.4	1.0	3.6	-0.2	0.8	0.9	-0.1	-1.6	-1.9	-0.1	-0.6
Respiratory disease	0.3	0.7	2.4	0.1	0.0	-0.5	0.8	1.2	1.5	0.9	0.4
Type 2 Diabetes (T2D) (2018)	1.1	2.1	4.0	-1.7	-2.0	-0.7	-1.5	1.4	1.4	-1.3	-1.4
Lung FEV1/FVC ratio	1.3	6.4	17.6	1.8	2.2	0.8	2.8	2.9	-0.9	2.9	4.2
Lung FVC	0.6	3.0	9.0	3.0	2.5	-1.3	1.4	-1.1	-1.2	1.0	1.2
Neuroticism	5.4	12.9	27.3	-3.6	-5.2	-2.1	-2.9	2.8	4.6	-2.9	-3.5
Chronotype (morning person)	0.6	1.4	2.5	0.9	1.2	1.6	1.1	-0.8	-1.5	1.2	0.9
Hair Pigment	0.0	0.7	1.8	-1.4	-0.9	-0.2	-0.8	1.2	0.8	-0.4	0.2
Tanning	0.0	0.6	2.2	-0.5	-0.9	0.6	0.2	-1.5	-1.1	0.0	-0.4
Hand grip strength (left)	0.3	0.7	2.9	0.6	0.0	-1.0	0.2	1.0	1.7	0.3	0.1
Number of treatments/medications taken	1.2	2.1	6.0	-1.6	-1.4	-1.1	-1.5	-0.5	0.7	-1.5	-2.4
Average weekly spirits intake	0.7	0.8	2.0	-1.1	-0.6	0.9	-0.6	-1.2	0.1	-0.5	-1.4
Sensitivity / hurt feelings	2.3	3.9	7.3	-1.8	-2.7	-2.5	-1.6	1.3	2.1	-1.5	-1.8
Frequency of depressed mood in last 2 weeks	6.2	8.7	17.6	-3.0	-4.2	-2.9	-2.8	1.3	3.0	-2.6	-3.0
Hearing difficulty/problems: Yes	0.6	0.9	3.6	0.2	0.2	-0.9	0.7	1.9	0.6	0.7	1.3
Relative age of first facial hair	0.2	0.5	1.5	1.2	1.0	-0.2	0.3	0.7	0.7	0.4	0.1
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	3.1	-1.7	-1.3	-1.0	-1.7	-0.6	-0.8	-1.8	-1.6
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.7	-0.1	-0.5	-0.4	0.3	0.8	0.5	0.2	-0.3
Ever had hysterectomy (womb removed)	0.5	0.6	3.1	-0.7	0.4	0.6	-0.4	-0.6	-1.8	-0.5	0.1
Systolic blood pressure, automated reading	0.1	0.2	0.5	-0.3	-0.7	-0.2	0.5	-0.7	-0.5	0.5	0.3
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.8	-1.0	-1.7	-1.3	-0.9	0.1	0.4	-1.1	-0.8
Angina	0.3	0.4	0.8	0.3	0.3	0.0	0.9	0.7	-0.4	0.8	0.9
Medication for hormone replacement therapy	0.8	0.9	3.0	0.3	-0.3	0.2	-0.5	0.8	1.5	-0.7	-1.7
Vitamin and mineral supplements	0.9	1.2	3.9	0.8	1.3	0.9	0.6	-2.0	-1.5	0.6	0.1
Supplements: Zinc	0.4	0.4	1.6	-0.9	-0.5	0.3	-0.2	-0.2	0.3	-0.4	-1.3
Medication: Co-codamol	0.7	0.9	2.6	-1.6	0.1	0.4	-0.9	-0.8	-1.3	-0.7	-0.7
Medication: Metformin	2.7	3.8	8.9	-2.8	-3.0	-0.6	-2.1	-0.3	0.3	-2.1	-2.1
Diabetes (father)	0.1	0.1	0.4	0.2	0.2	-0.3	0.3	-0.2	0.6	0.2	0.1
Diabetes (mother)	0.9	1.1	2.9	0.7	-0.4	-1.7	0.9	1.3	0.4	1.1	1.3
Severe depression (siblings)	0.5	0.6	2.2	0.4	-0.7	-1.5	0.8	0.5	0.5	0.8	0.1
Pack years adult smoking proportion	3.6	5.5	13.2	-2.6	-2.1	0.3	-2.9	-1.6	0.2	-3.0	-3.6
Impedance of leg (right)	1.2	5.8	12.8	-3.6	-2.0	-0.4	-3.6	0.2	-0.3	-3.3	-2.4
Leg fat-free mass (left)	0.2	0.9	2.6	1.3	0.3	0.3	1.6	-1.1	-0.2	1.2	0.4
Trunk fat percentage	0.2	0.9	2.9	-1.7	-1.5	0.7	-0.1	-0.7	-0.1	0.1	-1.0
Hand grip strength (right)	0.3	0.7	2.0	1.1	-0.3	-1.4	0.2	-0.4	1.3	0.0	-0.5
Townsend deprivation index at recruitment	1.2	1.6	3.4	-1.8	-0.8	1.0	-1.4	-1.5	-1.0	-1.3	-1.1
Current tobacco smoking	3.0	4.9	10.7	-3.3	-2.8	-1.2	-2.9	0.6	0.7	-2.5	-1.8
Average weekly fortified wine intake	0.2	0.3	1.4	0.1	-0.1	-0.0	0.3	1.2	0.7	0.2	0.5
Maternal smoking around birth	1.5	2.1	5.1	-2.0	-2.3	-0.9	-1.4	0.9	0.6	-1.4	-1.3
Fed-up feelings	2.0	3.7	7.8	-2.3	-2.8	-0.7	-1.6	1.8	2.3	-1.1	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	4.2	5.6	10.4	-2.7	-3.2	-2.0	-1.9	1.8	3.0	-1.5	-2.2
Relative age voice broke	0.5	0.8	1.8	1.0	1.4	0.3	0.5	-1.1	-1.1	0.5	0.7
Taking other prescription medications	0.8	1.2	4.3	-0.3	-1.0	-1.4	0.1	1.2	2.1	0.2	-1.1
Age when periods started (menarche)	0.3	0.8	1.4	-1.1	-1.0	-1.2	-1.2	-0.2	-0.2	-1.1	-0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	-0.1	-0.0	0.5	-0.3	-0.4	-0.0	-0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.8	0.3	0.3	-1.2	0.6	1.7	0.8	1.0	0.9
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	4.1	-0.1	0.3	0.1	0.5	-2.0	-1.5	0.5	0.3
Qualifications: CSEs or equivalent	1.2	1.5	3.3	-0.7	-1.0	-0.9	-1.4	0.3	1.7	-1.3	-1.8
Serious illness, injury or assault to yourself	1.9	2.3	3.6	-1.9	-1.4	-1.1	-1.9	1.0	0.4	-1.7	-1.9
High blood pressure	0.4	1.2	3.6	-1.9	-1.2	0.6	-0.9	-0.9	-0.9	-0.9	-1.1
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.0	-0.1	0.5	-0.5	0.1	0.8	-0.4	0.2	1.0
Multivitamins +/- minerals	1.5	1.8	7.1	-1.0	-1.2	-0.9	-0.5	2.7	1.9	-0.6	-0.3
Stomach or abdominal pain in last month	0.7	0.8	1.8	-0.6	0.3	1.3	-1.3	0.3	0.2	-1.2	-1.1
Supplements: Glucosamine	0.9	1.1	3.9	0.4	0.3	-0.7	1.1	1.3	-0.6	1.0	2.0
Diverticular disease/diverticulitis (self-reported)	3.2	3.7	11.9	2.9	3.5	0.7	1.7	-0.8	-1.2	1.5	1.3
Medication: Atenolol	0.4	0.5	1.2	-1.1	-0.9	0.7	-0.7	0.9	-0.0	-0.4	-0.1
Medication: Levothyroxine sodium	0.6	1.0	2.3	0.8	1.5	1.0	0.9	-0.8	-1.3	0.7	0.0
Sitting height	0.7	5.3	8.2	-2.4	-2.9	-2.1	-2.8	-0.6	0.9	-2.7	-2.8
Chronic bronchitis/emphysema (father)	1.4	1.6	4.7	-1.0	-2.2	-1.4	-1.0	1.2	1.1	-0.8	-1.1
High blood pressure (mother)	0.2	0.2	0.5	-0.2	0.2	-0.7	-0.3	0.7	-0.3	-0.3	0.7
Body mass index (BMI)	0.2	0.7	2.1	0.4	0.1	0.7	1.5	-0.6	-0.2	1.5	0.6
Impedance of leg (left)	1.1	5.4	12.3	-3.5	-2.0	-0.3	-3.5	0.5	0.2	-3.1	-2.3
Leg predicted mass (left)	0.2	1.0	2.7	1.4	0.4	0.3	1.6	-1.1	-0.3	1.3	0.4
Trunk fat mass	0.1	0.6	2.2	-1.2	-1.5	0.5	0.3	-0.7	0.1	0.3	-0.7
Waist circumference	0.1	0.5	1.4	-1.0	-1.2	0.9	0.3	-0.6	-0.3	0.2	-0.6
Number of incorrect matches in round	1.1	1.8	4.8	1.2	0.5	0.1	2.1	0.5	0.6	2.2	1.6
Past tobacco smoking	2.3	4.3	10.0	1.6	2.1	1.7	1.9	-3.2	-2.7	1.6	0.9
Alcohol usually taken with meals	1.0	1.7	3.4	1.3	0.2	-1.8	0.7	1.8	1.8	0.9	0.6
Nervous feelings	0.4	0.8	2.7	0.9	-0.6	-1.6	0.4	0.5	1.3	0.4	0.1
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.2	6.9	-2.2	-2.6	-2.0	-1.1	2.0	1.9	-0.7	-0.5
Hearing difficulty/problems with background noise	1.7	2.7	5.5	-1.2	-1.7	-1.0	-1.4	2.4	2.3	-1.2	-1.4
Hair/balding pattern: Pattern 2	1.8	2.3	8.4	1.2	0.8	2.9	1.3	-2.1	-0.5	1.2	0.2
Had menopause	0.3	0.4	1.1	1.0	0.3	0.6	1.0	-0.5	-0.3	0.7	0.3
Had other major operations	1.5	1.8	2.9	-1.7	-1.6	-1.4	-1.6	0.2	0.4	-1.4	-1.5
Forced vital capacity (FVC)	0.4	1.5	5.8	1.4	1.3	-0.4	-0.0	-2.4	-1.4	-0.4	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.9	0.5	0.1	-1.4	0.7	1.2	0.9	0.9	0.5
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.8	-0.7	-0.3	-1.4	-0.2	0.9	0.4	-0.0	0.3
Qualifications: None of the above	1.1	2.3	6.0	-2.4	-2.5	-1.3	-0.8	1.0	1.3	-0.5	-1.1
Financial difficulties in last 2 years	1.1	1.4	2.8	-1.7	-1.5	-1.7	-0.9	1.3	0.7	-0.6	-0.5
Mouth/teeth dental problems	0.7	1.1	2.9	0.9	1.1	-0.3	1.1	-0.9	-1.7	0.9	1.1
Heart attack	0.8	1.1	2.5	-1.5	-0.2	0.1	-1.6	1.3	0.1	-1.3	-0.8
Allergy	0.0	0.1	0.4	0.3	-0.3	0.1	-0.0	-0.6	0.1	-0.1	-0.4
Pain all over the body in last month	0.6	0.7	1.6	-1.3	-1.0	0.1	-0.9	0.7	0.8	-0.7	-0.4
Diabetes (self-reported)	1.4	2.2	5.7	-1.6	-2.4	-1.3	-1.5	0.2	0.8	-1.5	-1.6
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	4.0	1.3	2.0	0.5	1.5	-0.2	-1.1	1.5	1.8
Medication: Ramipril	0.5	0.7	1.7	-0.9	-0.5	1.3	0.8	0.9	0.0	1.0	0.6
Medication: Simvastatin	0.6	0.9	3.3	-1.8	-1.4	-0.8	-0.7	0.0	-0.8	-0.6	-0.4
Fluid intelligence score	0.6	1.2	3.5	0.5	-0.5	-0.5	-1.2	-1.1	0.3	-1.9	-1.7
Illnesses of siblings	0.3	0.5	1.2	-0.9	0.2	1.0	-0.6	1.1	-0.3	-0.3	0.6
Neuroticism score	4.5	9.4	20.9	-3.3	-4.6	-2.4	-2.5	2.3	3.6	-2.4	-2.8
Weight	0.1	0.4	1.2	0.2	-0.6	0.1	1.1	-0.8	0.0	1.0	0.2
Impedance of arm (right)	0.2	1.0	1.9	-1.3	-1.3	-0.2	-1.2	0.0	0.2	-1.3	-1.4
Arm fat percentage (right)	0.1	0.6	1.8	0.1	-0.5	0.7	1.4	-0.5	0.1	1.3	0.1
Trunk fat-free mass	0.1	0.4	1.0	1.0	-0.3	-0.4	0.9	-0.5	0.3	0.6	0.4
Hip circumference	0.3	1.4	4.1	1.5	0.6	0.4	2.0	-0.6	-0.1	1.8	1.0
Time employed in main current job	1.2	1.4	4.8	2.2	0.8	0.3	1.7	-0.9	0.5	1.2	0.6
Alcohol intake versus 10 years previously	0.6	0.8	3.5	-0.2	0.9	1.9	-0.9	0.7	-0.6	-0.8	-0.5
Father’s age at death	3.8	5.0	8.9	2.8	3.0	1.7	2.4	-0.5	-1.3	2.4	2.7
Worrier / anxious feelings	1.2	2.2	6.2	-1.2	-2.5	-0.9	-0.9	1.8	2.0	-0.8	-0.8
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	7.1	-2.6	-2.7	-0.4	-1.9	0.6	1.0	-1.7	-2.1
Falls in the last year	1.2	1.7	3.0	-1.4	-1.6	-1.7	-0.9	1.4	1.2	-1.1	-0.8
Hair/balding pattern: Pattern 3	0.7	1.1	1.8	-1.3	-0.3	-1.2	-1.4	0.3	-1.3	-1.1	-0.3
Number of live births	2.1	3.0	7.4	1.4	1.5	0.1	2.4	0.4	-0.3	2.7	2.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	2.9	1.7	1.6	-1.0	0.5	-0.9	-1.0	0.1	1.2
Pulse rate	0.7	1.2	6.7	-0.3	0.6	2.6	0.5	-0.8	-0.9	0.6	0.4
Happiness	2.2	2.7	10.0	0.6	-1.8	-1.4	-0.1	2.5	3.2	0.0	0.1
Noisy workplace	0.9	1.1	3.1	-1.8	-1.1	-0.3	-1.4	-0.6	-0.8	-1.2	-0.6
Qualifications: A levels/AS levels or equivalent	1.5	3.2	7.9	2.8	2.1	1.6	1.9	-1.1	-1.3	1.4	1.7
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	2.6	-1.2	-0.3	0.8	-1.5	-1.1	-1.0	-1.6	-1.1
Mouth/teeth dental problems: Dentures	0.9	1.6	4.9	-1.5	-2.2	-1.2	-0.5	1.5	1.2	-0.1	-0.2
Asthma	0.1	0.2	0.8	0.0	-0.6	-0.6	0.5	0.2	0.9	0.3	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.9	-0.9	-0.8	0.2	-0.3	0.0	0.7	-0.4	-0.2
Medication: Cholesterol lowering	1.1	1.8	3.1	-1.7	-1.3	-0.7	-1.6	-0.6	-0.5	-1.8	-1.7
Depression (self-reported)	3.2	3.8	7.5	-1.5	-1.4	-0.7	-2.2	1.4	2.7	-2.2	-2.6
Medication: Lansoprazole	1.0	1.2	4.0	-0.7	0.0	0.8	-1.2	0.6	0.8	-1.3	-2.0
Prospective memory result	0.5	0.7	2.2	-0.4	0.4	1.5	0.7	0.6	-0.2	1.0	1.0
Lung cancer (father)	0.6	0.6	3.7	-0.9	-0.4	1.9	-0.3	-0.2	0.3	-0.3	-0.5
Illnesses of mother	0.2	0.2	0.9	-0.1	-0.1	-0.4	-0.2	-1.0	-0.1	-0.3	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.1	1.7	1.8	-0.7	0.5	-0.9	-0.9	0.1	1.0
Pulse wave Arterial Stiffness index	2.0	2.4	6.5	-2.4	-2.5	-0.1	-1.5	-0.1	0.8	-1.5	-1.4
Impedance of arm (left)	0.5	2.2	4.3	-2.1	-1.5	-0.6	-1.9	-0.4	-0.4	-2.0	-1.7
Arm fat mass (right)	0.1	0.6	1.8	0.2	-0.5	0.5	1.4	-0.9	-0.1	1.3	0.1
Trunk predicted mass	0.1	0.4	1.0	1.0	-0.2	-0.4	0.9	-0.6	0.2	0.6	0.3
Standing height	0.1	1.2	3.3	-0.7	-1.8	-1.2	-0.9	-0.3	0.8	-1.2	-1.2
Length of working week for main job	0.5	0.5	1.0	-0.8	-1.0	0.3	-0.6	1.0	0.7	-0.3	-0.5
Exposure to tobacco smoke at home	0.8	0.9	3.7	-1.4	-1.9	0.2	-0.3	0.2	1.0	0.0	-0.5
Breastfed as a baby	1.3	1.6	9.8	-0.3	0.6	-0.7	0.1	-1.1	-3.1	-0.2	0.7
Tense / ‘highly strung’	3.3	5.4	12.7	-2.8	-3.6	-1.3	-1.9	1.0	2.6	-1.6	-2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	5.3	8.2	14.3	-2.4	-3.5	-3.5	-2.3	1.3	3.8	-2.3	-2.9
Hair/balding pattern: Pattern 4	0.6	1.4	4.5	0.6	-0.2	-1.7	0.2	2.1	1.7	0.4	0.9
Birth weight of first child	2.5	4.5	8.0	2.3	2.8	2.2	2.3	-0.4	-1.5	2.3	2.2
Peak expiratory flow (PEF)	0.4	0.9	3.3	0.8	0.8	-0.8	1.0	0.3	-0.6	0.8	1.8
Pulse wave reflection index	1.0	1.2	3.6	-0.2	-0.7	-1.8	-0.8	0.7	1.9	-0.7	-0.9
Ever highly irritable/argumentative for 2 days	3.5	4.2	8.0	-2.3	-2.3	-0.5	-1.9	1.7	2.8	-1.6	-2.4
Loud music exposure frequency	1.1	1.2	3.1	-0.8	-1.1	0.8	-1.3	-0.0	-0.1	-1.5	-1.8
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.0	1.0	1.6	1.7	0.4	-1.7	-1.1	0.0	0.1
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	3.6	-1.5	-1.0	1.0	-1.7	-0.2	0.9	-1.8	-1.9
Blood clot in the leg (DVT)	0.5	0.7	2.0	-1.3	-0.3	1.4	-1.0	0.2	-0.1	-0.6	-0.8
Medication: Paracetamol	0.2	0.4	1.0	-0.4	-1.0	-0.1	-0.1	-0.4	0.8	-0.4	-1.0
Headache pain in last month	0.3	0.4	1.7	-0.9	-0.4	-0.1	-0.3	-1.3	-0.7	-0.4	-0.5
Medication for cholesterol, blood pressure or diabetes	1.4	2.2	5.0	2.2	1.3	0.1	1.9	0.7	0.6	1.9	1.8
Glaucoma (self-reported)	1.8	2.1	5.7	1.1	1.0	-0.2	2.4	0.2	0.4	2.4	1.8
Gout (self-reported)	0.9	1.2	4.2	-0.4	-1.1	-1.0	-0.2	2.0	1.8	0.2	0.3
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	5.9	0.1	1.4	1.5	0.3	-1.7	-2.4	0.2	-0.3
Medication: Amlodipine	0.4	0.6	1.7	-0.6	-0.6	-1.1	0.7	0.6	-0.2	0.5	1.3
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.1	-1.4	-0.7	0.8	-0.7	-0.5	-0.5	-0.5	-1.1
Birth weight	1.2	2.6	6.3	1.8	0.7	0.2	2.5	0.6	0.2	2.2	2.2
Chronic bronchitis/emphysema (mother)	2.3	2.7	5.3	-2.1	-2.3	-1.0	-2.1	-0.1	0.2	-2.0	-1.6
High blood pressure (siblings)	0.5	0.8	2.7	1.6	0.6	-0.4	0.9	0.4	1.1	0.7	0.4
Forced vital capacity (FVC), Best measure	0.4	1.4	5.4	1.5	1.5	-0.4	0.1	-2.3	-0.9	-0.4	-0.1
Body fat percentage	0.2	0.6	2.0	-1.4	-1.2	0.7	0.2	-0.5	-0.2	0.3	-0.7
Leg fat percentage (right)	0.1	0.5	1.9	-1.4	-0.7	1.0	0.1	-0.1	-0.2	0.3	-0.3
Arm fat-free mass (right)	0.1	0.3	1.1	0.6	-0.2	-0.3	0.8	-1.0	-0.1	0.5	0.2
Exposure to tobacco smoke outside home	1.3	1.7	4.5	-2.1	-1.6	0.1	-1.5	-0.8	-0.2	-1.4	-1.4
Comparative body size at age 10	0.3	1.0	2.4	1.1	0.3	0.1	1.5	-0.2	0.4	1.2	1.5
Number of full brothers	0.3	0.4	1.0	0.4	0.8	0.3	-0.1	-0.9	-0.4	-0.3	-1.0
Worry too long after embarrassment	2.9	4.9	11.9	-1.6	-3.4	-2.9	-0.9	1.6	3.3	-0.9	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	3.0	3.9	6.5	-2.2	-1.9	-2.1	-2.6	-0.1	0.1	-2.6	-2.3
Wheeze or whistling in the chest in last year	0.6	1.0	2.6	-1.1	-0.9	-0.2	-0.7	1.6	1.5	-0.4	-0.7
Number of children fathered	0.2	0.2	0.9	0.2	0.5	0.3	-0.1	0.9	0.3	0.1	0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.1	1.1	1.2	1.8	1.4	-0.6	-1.6	1.3	1.6
Age at first live birth	0.4	0.7	2.4	1.2	1.6	0.3	0.3	-0.2	-1.0	-0.2	0.2
Pulse wave peak to peak time	2.0	2.3	6.4	2.4	2.5	0.1	1.5	0.1	-0.7	1.4	1.2
Health satisfaction	0.2	0.3	1.1	0.7	0.7	1.0	0.2	-0.2	-0.3	0.2	0.3
Shortness of breath walking on level ground	1.0	1.2	3.5	-1.9	-0.9	0.9	-0.3	-1.5	-0.9	-0.4	-0.9
Qualifications: College or University degree	2.4	7.5	15.8	3.9	4.0	1.2	2.8	-0.7	-2.1	2.4	3.0
Eye problems/disorders: None of the above	0.1	0.2	0.8	-0.2	-0.1	-0.9	0.1	0.4	-0.2	0.3	0.5
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.0	0.0	1.4	0.0	-1.2	0.2	-0.6	-0.9	-0.4
Emphysema/chronic bronchitis	0.8	0.9	2.0	-0.3	1.0	1.2	-0.5	-1.4	-0.9	-0.2	-1.1
Medication for pain relief, constipation, heartburn	0.4	0.6	2.8	0.9	1.7	0.2	-0.1	-0.5	-1.0	0.0	0.4
Neck or shoulder pain in last month	0.9	1.3	3.1	-1.8	-1.6	-0.4	-0.7	-0.4	0.6	-0.8	-1.7
Medication: Blood pressure	2.0	3.6	8.1	-2.8	-1.5	1.1	-2.4	-0.6	-0.1	-2.2	-2.5
Angina (self-reported)	0.2	0.3	0.6	0.2	0.2	0.1	0.8	0.6	-0.4	0.7	0.7
Migraine (self-reported)	0.5	0.6	1.6	0.9	0.9	0.3	-0.1	-1.1	0.3	-0.3	-1.3
Medication: Ibuprofen	0.3	0.4	0.8	-0.9	-0.8	0.2	-0.3	-0.8	0.3	-0.5	-0.7
Medication: Allopurinol	0.7	0.9	2.5	-0.2	-0.9	-0.9	0.4	1.6	1.2	0.7	0.9
Medication: Omeprazole	0.3	0.3	0.8	-0.5	0.1	0.8	-0.9	0.3	-0.4	-0.7	-0.5
Medication: Seretide 50 evohaler	1.0	1.2	3.0	-1.1	-1.7	-0.3	-1.0	-0.1	1.2	-1.0	-1.4
Mean time to correctly identify matches	0.9	1.8	5.7	-1.0	-2.0	-1.2	-0.1	2.4	1.2	0.5	0.6
Heart disease (mother)	0.5	0.6	2.3	0.5	0.4	1.0	-0.0	-1.5	-1.0	-0.3	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.1	0.1	0.7	0.4	0.3	1.4	1.1	0.8	0.8
Whole body fat mass	0.1	0.4	1.2	-0.8	-1.1	0.6	0.5	-0.4	0.2	0.5	-0.5
Leg fat mass (right)	0.1	0.4	0.9	-0.4	-0.4	0.8	0.9	-0.4	-0.1	1.0	0.1
Arm predicted mass (right)	0.1	0.3	1.5	0.3	-0.4	-0.2	0.5	-1.2	-0.2	0.3	-0.1
Pulse rate, automated reading	1.9	6.0	15.3	1.3	3.0	3.9	1.2	-3.1	-3.3	1.0	0.4
Alcohol intake frequency.	0.5	1.1	5.6	-0.5	0.2	0.2	-0.5	-2.4	-0.9	-0.4	-1.1
Comparative height size at age 10	0.1	0.4	1.3	-0.8	-1.2	-0.8	0.2	-0.0	0.6	0.1	-0.3
Number of full sisters	0.7	0.8	2.3	-1.5	-0.8	0.4	-0.6	-0.8	-1.4	-0.7	-0.3
Suffer from ‘nerves’	1.2	1.8	2.8	-1.6	-1.6	-1.7	-1.3	0.8	1.4	-1.1	-1.2
Overall health rating	2.1	4.5	10.3	-2.3	-1.5	-0.4	-2.3	-2.6	-0.8	-2.4	-3.2
Chest pain or discomfort	0.7	0.9	2.8	-1.3	-1.5	0.4	-0.4	-0.3	0.6	-0.5	-1.7
Had major operations	2.8	3.3	5.4	-1.6	-1.9	-1.4	-2.3	1.7	1.5	-2.2	-1.6
Age at last live birth	0.4	0.5	1.8	-0.0	1.3	0.5	-0.2	-0.7	-1.2	-0.3	0.1
Family relationship satisfaction	1.7	2.2	6.0	-0.8	-1.6	-1.1	-0.8	2.4	2.4	-0.5	-0.4
Leg pain on walking	0.5	0.6	2.1	-1.5	-1.0	0.4	-0.8	0.4	-0.4	-0.6	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.0	-1.0	-0.6	-0.4	-0.4	-0.1	-0.2	-0.4	-0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.9	0.0	0.6	1.0	-0.5	0.3	0.1	-0.5	-0.1
Illness, injury, bereavement, stress in last 2 years	2.8	3.4	7.2	2.7	1.9	1.5	2.2	-1.5	-1.0	1.9	1.6
Medication: Aspirin	0.1	0.1	0.6	-0.8	-0.5	0.1	-0.1	0.1	-0.4	-0.2	-0.3
Supplements: Vitamin C	0.5	0.6	1.8	-0.7	-1.3	-0.3	-0.5	0.4	1.3	-0.4	-0.4
Knee pain experienced in last month	0.6	1.0	2.1	0.2	1.4	1.5	0.5	-1.4	-1.1	0.4	-0.4
Hypertension (Self-reported)	0.5	1.3	3.8	-1.9	-1.6	0.4	-1.1	-0.5	-0.4	-1.1	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.7	1.6	1.6	0.7	0.1	-0.1	1.0	0.0	-1.0
Illnesses of father: Heart disease	0.2	0.3	1.1	0.0	0.3	1.1	-0.2	-0.1	-0.7	-0.3	0.6
Illnesses of siblings: Diabetes	1.1	1.4	3.2	-0.7	-1.2	-1.1	-0.7	-1.6	-0.2	-1.3	-1.8
Smoking status: Previous	2.1	3.1	10.4	-0.8	-1.5	-0.7	-0.9	3.2	3.1	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	5.6	-1.8	-2.0	-0.8	-2.3	0.2	0.7	-2.4	-2.1
Whole body fat-free mass	0.1	0.5	1.4	1.2	0.0	0.0	1.2	-0.7	0.2	0.9	0.3
Leg fat-free mass (right)	0.2	0.9	2.6	1.5	0.3	0.1	1.6	-0.8	0.3	1.3	0.4
Arm fat percentage (left)	0.1	0.4	1.0	-0.3	-0.5	0.6	1.0	-0.8	-0.4	1.0	-0.0
Average weekly red wine intake	0.4	0.6	1.4	-0.8	-1.2	0.2	-1.0	0.7	0.4	-1.1	-0.4
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.8	-0.2	-0.7	-1.3	-0.2	-0.0	-0.0	-0.3	-0.2
Mood swings	2.2	4.0	9.4	-1.4	-2.5	-0.9	-1.5	2.1	3.1	-1.4	-2.3
Loneliness, isolation	1.8	2.5	7.4	-1.3	-2.7	-1.1	-1.0	0.3	1.9	-1.2	-1.7
Long-standing illness, disability or infirmity	1.6	2.4	6.8	-1.8	-0.7	0.7	-1.5	-1.6	-1.1	-1.6	-2.6
Ever had bowel cancer screening	0.6	0.7	2.9	0.6	1.3	1.7	0.2	0.4	-0.0	0.1	0.5
Diabetes diagnosed by doctor	1.5	2.4	5.5	-2.0	-2.3	-1.0	-1.7	0.0	0.4	-1.7	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.7	-0.4	0.1	0.5	-0.5	-0.3	0.6	-0.4	-0.8
Friendships satisfaction	2.1	2.6	8.6	-0.3	-1.1	-1.9	-0.8	2.9	2.5	-0.5	-0.4
Qualifications: nursing, teaching	0.6	1.0	2.2	1.5	1.1	1.0	0.8	-1.5	-0.3	0.4	0.5
Commuting to job workplace: Walk	0.9	0.9	2.3	-0.8	-1.3	-1.5	-0.9	-0.1	0.7	-0.8	-0.9
Eye problems/disorders: Cataract	0.9	1.0	5.5	0.3	0.7	2.3	-0.0	-0.7	-1.1	-0.3	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	3.0	1.4	1.2	1.7	0.8	0.6	0.5	0.8	0.2
Medication for cholesterol	0.5	0.8	2.2	0.6	1.5	0.2	0.7	-0.4	-0.8	0.8	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.2	-0.3	-0.4	0.7	-0.4	-1.1	-1.0	-0.6	0.1
Back pain experienced in last month	0.6	0.8	2.0	-1.0	-0.7	-1.4	-0.9	-0.4	0.2	-1.1	-1.0
Mineral and other dietary supplements	0.2	0.2	0.7	0.9	0.4	0.1	0.3	-0.0	0.8	0.5	0.3
Breast cancer (self-reported)	0.6	0.7	2.2	1.5	0.7	0.2	0.2	-0.2	1.3	-0.0	-1.2
Asthma (self-reported)	0.1	0.2	0.9	-0.0	-0.4	-0.4	0.4	0.3	1.0	0.2	-0.4
Osteoporosis (self-reported)	0.3	0.3	1.1	0.6	0.5	1.1	-0.3	0.2	-0.1	-0.7	-0.4
Osteoarthritis (self-reported)	1.2	1.6	3.6	0.8	1.5	1.2	0.9	-1.9	-1.7	0.8	0.3
Medication: Aspirin	0.1	0.1	0.5	-0.4	-0.1	0.1	0.4	-0.2	-0.7	0.2	0.3
Medication: Gliclazide	1.2	1.4	4.9	-0.6	-0.9	-0.5	0.8	2.2	-0.2	1.3	1.5
Illnesses of father: None of the above (group 1)	0.2	0.2	0.9	-0.4	0.0	0.6	0.2	-1.0	-0.5	0.1	-0.0
Smoking status: Current	3.6	5.7	12.2	-3.5	-3.0	-1.5	-3.2	0.9	0.6	-2.8	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	5.8	1.3	0.0	-2.4	1.0	0.6	0.1	1.1	2.0
Whole body water mass	0.1	0.7	1.8	1.3	0.1	-0.2	1.3	-0.8	0.2	1.0	0.4
Leg predicted mass (right)	0.2	1.0	2.9	1.5	0.3	0.1	1.7	-0.8	0.2	1.4	0.5
Arm fat mass (left)	0.1	0.5	1.3	0.0	-0.5	0.5	1.1	-0.9	-0.1	1.1	-0.1
Number of self-reported non-cancer illnesses	1.0	1.8	4.9	-1.8	-1.6	-0.0	-1.3	-0.4	0.7	-1.3	-2.2
Average weekly champagne plus white wine intake	1.8	2.4	6.6	2.5	2.6	0.4	1.6	0.4	-0.8	1.4	1.1
Miserableness	3.0	5.2	11.4	-1.8	-3.2	-2.2	-1.3	2.7	3.4	-1.0	-1.4
Guilty feelings	2.1	3.1	7.3	-1.7	-2.7	-2.4	-1.4	0.8	1.5	-1.4	-1.5
Wears glasses or contact lenses	1.0	1.2	2.7	-0.9	-1.1	0.1	-1.1	-1.0	0.5	-1.6	-1.7
Ever taken oral contraceptive pill	2.4	2.6	5.3	-2.0	-1.4	-2.3	-1.9	0.9	-0.5	-1.9	-1.1
Hearing aid user	0.7	0.8	3.4	-0.2	-0.8	-0.9	-0.3	0.8	1.8	-0.1	-0.7
Mother’s age at death	3.2	4.0	8.0	1.9	2.0	-0.6	2.0	2.5	0.4	2.4	2.8
Financial situation satisfaction	1.2	1.4	6.1	0.1	-1.2	-1.0	-0.2	1.6	2.5	-0.0	-0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.7	0.1	-0.1	0.3	-0.7	-0.1	-0.6	-0.9	-0.4
Commuting to job workplace: Public transport	1.4	1.6	7.9	0.1	0.3	-0.8	0.3	2.8	1.9	0.7	0.6
Eye problems/disorders: Glaucoma	0.8	1.0	2.4	1.0	0.8	-0.3	1.1	0.8	1.5	1.2	0.6
Medication: Blood pressure	0.1	0.2	0.9	-0.2	-0.1	0.3	0.3	1.0	0.4	0.4	0.0
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.1	-1.8	-1.3	-0.7	-1.2	0.6	1.2	-1.0	-1.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.2	-1.5	-1.1	-0.5	-0.8	-0.4	-0.2	-0.9	-0.9
High cholesterol (Self-reported)	0.7	1.2	2.9	-1.0	-1.7	-0.0	-1.2	-0.4	0.0	-1.5	-1.5
Medication: Bendroflumethiazide	0.5	0.8	3.7	-0.6	0.1	1.9	0.2	-1.0	-0.6	0.1	-0.7
Medication: Paracetamol	0.3	0.5	1.5	-0.0	-0.5	-0.2	0.1	-1.1	0.6	-0.4	-1.2
Medication: Lisinopril	0.3	0.4	1.6	-1.2	-0.9	-0.2	-0.7	0.4	0.0	-0.4	-0.2
Medication: Atorvastatin	2.7	3.3	8.1	-1.8	-2.1	-0.3	-2.3	-0.3	-0.2	-2.9	-2.3
Illnesses of father: High blood pressure	0.3	0.3	1.4	0.6	1.2	0.4	0.3	0.3	0.1	0.5	0.4
Alcohol drinker status: Never	2.3	2.8	4.4	1.5	1.6	-0.2	2.0	-1.7	-1.7	1.8	2.1
Ever smoked	1.8	3.1	6.3	-1.1	-2.0	-2.5	-1.5	2.3	1.9	-1.4	-0.3
Basal metabolic rate	0.1	0.5	1.7	1.0	-0.1	-0.1	1.3	-0.7	0.2	1.0	0.4
Leg fat percentage (left)	0.1	0.5	1.9	-1.4	-0.7	1.0	0.2	0.1	-0.0	0.4	-0.2
Arm fat-free mass (left)	0.2	0.9	2.2	1.5	0.3	0.2	1.4	-1.0	0.2	1.2	0.3
Number of operations (self-reported)	0.9	1.3	2.8	-1.0	-1.0	-0.5	-1.7	1.0	0.3	-1.5	-1.4
Average weekly beer plus cider intake	0.5	0.7	1.6	-1.0	-0.4	-0.1	-1.1	0.1	0.8	-0.8	-1.3
Irritability	5.6	9.5	14.6	-3.1	-3.8	-2.2	-3.2	1.6	3.6	-3.1	-3.4
Risk taking	1.2	1.8	3.7	-1.5	-0.9	-0.9	-1.7	-0.1	0.2	-1.8	-1.9
Ever had prostate specific antigen (PSA) test	1.8	2.0	7.3	-2.7	-1.7	-0.8	-1.3	1.4	0.9	-0.9	-0.5
Fractured/broken bones in last 5 years	0.3	0.4	0.7	0.0	0.7	0.6	0.4	0.8	-0.6	0.6	0.8
Age started oral contraceptive pill	2.0	2.6	6.3	2.5	1.2	0.7	2.4	-0.4	-0.0	2.0	1.5
Diastolic blood pressure, automated reading	0.9	2.7	6.7	1.5	2.5	1.7	0.4	-2.6	-1.9	0.0	-0.3
Ever depressed for a whole week	0.7	0.9	3.8	-0.8	-1.0	-1.9	-0.4	0.5	0.9	-0.5	-0.4
Unable to work because of sickness or disability	1.6	2.1	4.5	-2.1	-1.7	-0.6	-1.9	0.5	0.9	-1.6	-1.4
Commuting to job workplace: Cycle	1.0	1.2	3.6	1.0	0.2	-1.9	1.1	-0.2	0.2	1.0	1.5
Myopia	0.7	1.0	3.5	-0.8	-1.0	-1.9	-0.7	1.4	0.5	-0.5	0.1
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.6	1.3	0.9	-0.1	0.4	0.8	0.9	0.5	0.7
Cholesterol lowering medication	0.9	1.3	4.3	-1.6	-2.1	-0.3	-1.0	1.1	0.0	-1.0	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.0	0.3	0.6	1.0	-0.3	0.0	-0.0	-0.2	-0.5
Pain experienced in last month	0.4	0.7	2.1	1.5	1.0	0.0	0.5	0.2	-0.9	0.5	1.1
Supplements: Calcium	0.9	1.0	1.5	-1.2	-0.9	1.1	-0.7	-0.7	-1.1	-0.9	-1.2
Basal cell carcinoma (self-reported)	0.3	0.4	1.0	-0.1	-0.6	-1.0	0.1	-1.0	0.3	-0.0	-0.7
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.3	-1.4	-0.1	0.1	-1.5	1.4	0.2	-1.2	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.6	-1.0	-0.3	1.3	-0.8	0.2	0.3	-0.5	-0.7
Heart disease (siblings)	1.5	1.9	3.4	-1.8	-1.9	-0.6	-1.4	-1.2	-1.1	-1.4	-1.3
Alcohol drinker status: Previous	0.1	0.1	0.5	-0.7	-0.4	-0.0	-0.0	0.1	-0.1	0.0	-0.1
Pack years of smoking	2.6	3.8	9.6	-2.0	-1.7	0.5	-2.1	-1.9	0.0	-2.3	-3.1
Impedance of whole body	0.9	4.4	9.5	-3.1	-1.9	-0.5	-2.9	0.0	-0.1	-2.8	-2.2
Leg fat mass (left)	0.1	0.4	1.2	-0.3	-0.3	0.9	1.0	-0.4	-0.2	1.1	0.2
Arm predicted mass (left)	0.2	0.8	2.0	1.4	0.3	0.3	1.4	-0.8	0.3	1.2	0.4