Hub : Genes

CC2D2A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Muscularis 0.1410 0.0620 8.6e-03 -0.002 NA -0.005 NA -0.003 4.2e-01 NA 8.6e-01 NA 5.5e-01
2 GTEx Testis 0.1370 0.0550 5.3e-03 0.023 NA 0.062 NA 0.032 3.1e-02 NA 9.7e-04 NA 1.4e-02
3 NTR Blood 0.0322 0.0106 1.3e-04 0.007 0.015 0.013 0.015 0.012 2.0e-03 7.5e-06 2.8e-05 8.5e-06 4.9e-05
4 ROSMAP Brain Pre-frontal Cortex 0.1497 0.0332 8.6e-12 0.141 0.102 0.122 0.127 0.132 9.7e-18 5.4e-13 2.0e-15 4.6e-16 1.1e-16
5 TCGA Head and Neck Squamous Cell Carcinoma 0.0508 0.0266 3.8e-03 -0.001 0.020 0.007 NA -0.001 4.9e-01 2.4e-03 4.4e-02 NA 4.0e-01
6 TCGA Kidney Renal Clear Cell Carcinoma 0.0585 0.0262 9.4e-04 0.011 0.024 0.005 NA 0.014 1.7e-02 9.7e-04 8.5e-02 NA 8.4e-03
7 TCGA Brain Lower Grade Glioma 0.0925 0.0382 1.2e-06 0.070 0.058 0.057 NA 0.063 2.2e-08 3.4e-07 4.9e-07 NA 1.0e-07
8 TCGA Thyroid Carcinoma 0.0360 0.0190 5.2e-03 0.004 0.005 -0.002 NA -0.002 1.1e-01 9.9e-02 7.3e-01 NA 5.7e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.1 0.2 0.4 0.2 0.1 -0.3 0.7 -0.5 -0.4 0.7 0.5
Bipolar Disorder or Schizophrenia 0.1 0.2 0.9 -0.2 0.3 0.6 0.5 0.5 -0.2 0.9 0.2
Depressed Affect (Nagel 2018) 4.2 8.8 21.3 -2.9 -4.6 -1.8 -2.0 2.4 4.1 -1.8 -2.7
Depression (Nagel 2018) 4.7 7.1 13.5 -2.7 -3.3 -2.4 -2.2 2.0 3.7 -2.0 -2.5
Intelligence (Savage-Jansen 2018) 0.5 1.6 5.2 2.3 1.1 0.2 1.2 -2.1 -0.6 0.3 0.3
Neuroticism (Nagel 2018) 6.2 14.5 32.0 -3.8 -5.7 -2.8 -3.2 2.4 4.6 -3.2 -3.8
Schizophrenia (2018) 0.2 0.4 1.1 -0.4 0.3 1.1 0.1 1.0 0.0 0.7 -0.1
Schizophrenia vs Biploar Disorder 0.5 0.6 3.6 0.1 0.1 1.9 0.1 -0.1 0.9 0.2 -0.7
Worry (Nagel 2018) 2.0 4.2 8.8 -1.9 -2.8 -1.1 -1.7 1.6 3.0 -1.6 -2.1
Alzheimer’s Disease (in mother) 2.2 2.6 7.8 0.4 0.1 0.0 1.2 2.8 2.5 1.8 1.5
Alzheimer’s Disease (in father) 0.7 0.8 2.5 0.7 1.2 1.6 0.8 -0.2 -0.2 0.9 0.6
Alzheimer’s Disease (including proxy) 0.7 1.0 2.4 -0.3 0.4 0.7 0.7 1.6 1.0 1.3 1.3
Crohns Disease (2017) 1.3 2.8 4.2 -1.3 -2.0 -1.6 -1.8 0.3 2.0 -1.6 -2.0
Irritable Bowel Disease (IBD) 0.6 1.4 3.8 -0.8 -1.0 -0.5 -1.3 -1.4 0.5 -1.2 -2.0
Ulcerative Colitis (UC) 0.7 1.4 5.4 0.6 1.1 0.6 0.6 -2.3 -1.7 0.5 0.1
Major Depression (MDD) 3.3 4.1 8.8 -3.0 -2.8 0.2 -1.9 -0.5 1.3 -1.8 -2.7
Reaction Time 0.7 1.4 3.7 -1.7 -1.9 -0.9 -1.1 1.4 0.2 -0.6 -0.1
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.9 1.3 0.0 -0.1 -0.5 -1.7 0.1 -1.4 -1.5
Breast Cancer 0.5 1.1 3.1 1.1 1.0 1.1 0.6 1.0 -0.3 0.7 1.8
Ovarian Cancer 0.8 1.1 3.9 -0.9 -0.1 0.5 -0.8 -1.4 -2.0 -1.0 0.0
Prostate Cancer 0.3 0.4 1.2 -0.1 0.1 1.1 0.2 0.0 -0.9 0.1 1.0
Age at First Birth 0.8 1.2 4.5 1.3 0.4 0.1 0.0 -2.1 -1.0 -1.0 -1.1
Bipolar Disorder (2011) 0.5 0.5 0.9 0.5 0.2 0.6 0.7 1.0 0.7 0.8 0.9
Body Mass Index (BMI) (2010) 0.7 0.9 3.1 0.6 1.6 1.8 0.3 0.4 -0.6 0.4 0.8
Coronary Artery Disease (CAD) 0.6 0.7 2.0 -1.3 -1.4 -0.4 -0.7 -0.6 -0.3 -0.6 -0.9
Crohns Disease (2012) 1.1 1.7 4.4 -1.0 -1.6 -1.2 -0.9 1.9 2.1 -0.4 -0.4
Mean Putamen Volume 0.8 0.9 3.8 0.0 -0.4 -0.3 0.0 1.8 1.9 0.1 0.1
Fasting Glucose 0.3 0.3 1.1 -0.7 -0.3 -1.0 -0.4 -0.5 -0.4 -0.5 -0.5
HbA1C 1.2 1.3 2.6 -1.0 -0.8 -1.6 -1.4 -0.0 0.6 -1.2 -1.5
HDL Cholesterol 0.1 0.2 0.7 0.2 -0.0 -0.7 0.7 -0.2 -0.0 0.8 0.4
LDL Cholesterol 0.5 0.7 1.5 0.6 1.2 0.8 0.6 -0.9 -1.0 0.7 0.7
Lupus 0.4 0.6 1.2 0.3 1.0 -0.6 0.8 0.1 -1.1 0.7 0.9
Neuroticism (2016) 3.2 4.7 7.9 -2.2 -2.1 -0.9 -2.5 0.4 2.8 -2.5 -2.7
Primary Biliary Cirrhosis 0.4 0.5 1.8 -1.3 -0.4 0.7 -0.6 -0.6 -0.6 -0.7 -0.3
Rheumatoid Arthritis 0.6 0.9 2.9 -0.2 0.5 1.7 -0.2 -1.5 -0.7 -0.2 -1.0
Schizophrenia (2014) 0.1 0.3 1.0 -0.5 0.2 1.0 -0.2 0.6 0.5 0.3 -0.7
Triglycerides 0.2 0.3 1.1 0.1 1.0 0.1 -0.0 0.8 -0.0 0.3 0.6
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.5 0.5 0.9 -0.0 0.4 -1.0 -1.2 -0.0 0.3
Ulcerative Colitis 0.8 1.2 6.9 0.3 -0.3 0.1 -0.3 -2.6 -0.7 -0.6 -1.2
Blood Eosinophil Count 0.4 3.3 15.4 -0.7 -1.6 -3.9 -0.6 0.9 2.3 -0.6 -1.0
Blood Platelet Count 0.0 0.3 1.3 -0.6 -0.7 -1.1 0.2 0.3 0.6 0.1 -0.0
Blood Red Count 2.1 20.5 40.1 -4.5 -4.8 -5.0 -4.7 -2.9 1.8 -4.7 -6.3
Blood White Count 0.5 3.8 7.2 -2.7 -2.1 -1.9 -1.9 -1.5 -0.1 -2.1 -2.3
Heel T-Score 0.3 2.5 4.9 1.4 1.5 1.2 1.9 1.4 1.3 2.2 1.7
BMI 0.4 2.4 6.4 1.1 0.8 1.0 2.5 -0.5 -0.7 2.5 1.5
Height 0.1 1.8 5.4 -0.3 -1.6 -0.9 -0.3 -1.4 1.6 -0.7 -2.3
Waist Hip Ratio (WHR) 3.0 13.4 36.9 -6.1 -5.0 0.4 -4.1 -0.8 -0.6 -3.8 -3.5
Systolic Blood Pressure 0.2 1.2 5.8 -2.4 -1.1 -0.7 -1.0 -0.3 -1.1 -0.7 -0.1
Smoking Status 3.0 7.2 12.5 -3.4 -3.0 -1.2 -3.5 1.9 2.1 -3.1 -2.4
Allergy or Eczema 0.4 1.0 3.2 0.8 1.0 -0.6 0.9 1.2 0.1 0.9 1.8
Cardiovascular Disease 0.6 2.0 3.4 -1.8 -1.3 -0.1 -1.4 -1.6 -1.6 -1.6 -1.1
Hypothyroidism (self reported) 0.4 1.0 3.6 -0.2 0.8 0.9 -0.1 -1.6 -1.9 -0.1 -0.6
Respiratory disease 0.3 0.7 2.4 0.1 0.0 -0.5 0.8 1.2 1.5 0.9 0.4
Type 2 Diabetes (T2D) (2018) 1.1 2.1 4.0 -1.7 -2.0 -0.7 -1.5 1.4 1.4 -1.3 -1.4
Lung FEV1/FVC ratio 1.3 6.4 17.6 1.8 2.2 0.8 2.8 2.9 -0.9 2.9 4.2
Lung FVC 0.6 3.0 9.0 3.0 2.5 -1.3 1.4 -1.1 -1.2 1.0 1.2
Neuroticism 5.4 12.9 27.3 -3.6 -5.2 -2.1 -2.9 2.8 4.6 -2.9 -3.5
Chronotype (morning person) 0.6 1.4 2.5 0.9 1.2 1.6 1.1 -0.8 -1.5 1.2 0.9
Hair Pigment 0.0 0.7 1.8 -1.4 -0.9 -0.2 -0.8 1.2 0.8 -0.4 0.2
Tanning 0.0 0.6 2.2 -0.5 -0.9 0.6 0.2 -1.5 -1.1 0.0 -0.4
Hand grip strength (left) 0.3 0.7 2.9 0.6 0.0 -1.0 0.2 1.0 1.7 0.3 0.1
Number of treatments/medications taken 1.2 2.1 6.0 -1.6 -1.4 -1.1 -1.5 -0.5 0.7 -1.5 -2.4
Average weekly spirits intake 0.7 0.8 2.0 -1.1 -0.6 0.9 -0.6 -1.2 0.1 -0.5 -1.4
Sensitivity / hurt feelings 2.3 3.9 7.3 -1.8 -2.7 -2.5 -1.6 1.3 2.1 -1.5 -1.8
Frequency of depressed mood in last 2 weeks 6.2 8.7 17.6 -3.0 -4.2 -2.9 -2.8 1.3 3.0 -2.6 -3.0
Hearing difficulty/problems: Yes 0.6 0.9 3.6 0.2 0.2 -0.9 0.7 1.9 0.6 0.7 1.3
Relative age of first facial hair 0.2 0.5 1.5 1.2 1.0 -0.2 0.3 0.7 0.7 0.4 0.1
Other serious medical condition/disability diagnosed by doctor 1.5 1.9 3.1 -1.7 -1.3 -1.0 -1.7 -0.6 -0.8 -1.8 -1.6
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.7 -0.1 -0.5 -0.4 0.3 0.8 0.5 0.2 -0.3
Ever had hysterectomy (womb removed) 0.5 0.6 3.1 -0.7 0.4 0.6 -0.4 -0.6 -1.8 -0.5 0.1
Systolic blood pressure, automated reading 0.1 0.2 0.5 -0.3 -0.7 -0.2 0.5 -0.7 -0.5 0.5 0.3
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 2.8 -1.0 -1.7 -1.3 -0.9 0.1 0.4 -1.1 -0.8
Angina 0.3 0.4 0.8 0.3 0.3 0.0 0.9 0.7 -0.4 0.8 0.9
Medication for hormone replacement therapy 0.8 0.9 3.0 0.3 -0.3 0.2 -0.5 0.8 1.5 -0.7 -1.7
Vitamin and mineral supplements 0.9 1.2 3.9 0.8 1.3 0.9 0.6 -2.0 -1.5 0.6 0.1
Supplements: Zinc 0.4 0.4 1.6 -0.9 -0.5 0.3 -0.2 -0.2 0.3 -0.4 -1.3
Medication: Co-codamol 0.7 0.9 2.6 -1.6 0.1 0.4 -0.9 -0.8 -1.3 -0.7 -0.7
Medication: Metformin 2.7 3.8 8.9 -2.8 -3.0 -0.6 -2.1 -0.3 0.3 -2.1 -2.1
Diabetes (father) 0.1 0.1 0.4 0.2 0.2 -0.3 0.3 -0.2 0.6 0.2 0.1
Diabetes (mother) 0.9 1.1 2.9 0.7 -0.4 -1.7 0.9 1.3 0.4 1.1 1.3
Severe depression (siblings) 0.5 0.6 2.2 0.4 -0.7 -1.5 0.8 0.5 0.5 0.8 0.1
Pack years adult smoking proportion 3.6 5.5 13.2 -2.6 -2.1 0.3 -2.9 -1.6 0.2 -3.0 -3.6
Impedance of leg (right) 1.2 5.8 12.8 -3.6 -2.0 -0.4 -3.6 0.2 -0.3 -3.3 -2.4
Leg fat-free mass (left) 0.2 0.9 2.6 1.3 0.3 0.3 1.6 -1.1 -0.2 1.2 0.4
Trunk fat percentage 0.2 0.9 2.9 -1.7 -1.5 0.7 -0.1 -0.7 -0.1 0.1 -1.0
Hand grip strength (right) 0.3 0.7 2.0 1.1 -0.3 -1.4 0.2 -0.4 1.3 0.0 -0.5
Townsend deprivation index at recruitment 1.2 1.6 3.4 -1.8 -0.8 1.0 -1.4 -1.5 -1.0 -1.3 -1.1
Current tobacco smoking 3.0 4.9 10.7 -3.3 -2.8 -1.2 -2.9 0.6 0.7 -2.5 -1.8
Average weekly fortified wine intake 0.2 0.3 1.4 0.1 -0.1 -0.0 0.3 1.2 0.7 0.2 0.5
Maternal smoking around birth 1.5 2.1 5.1 -2.0 -2.3 -0.9 -1.4 0.9 0.6 -1.4 -1.3
Fed-up feelings 2.0 3.7 7.8 -2.3 -2.8 -0.7 -1.6 1.8 2.3 -1.1 -1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 4.2 5.6 10.4 -2.7 -3.2 -2.0 -1.9 1.8 3.0 -1.5 -2.2
Relative age voice broke 0.5 0.8 1.8 1.0 1.4 0.3 0.5 -1.1 -1.1 0.5 0.7
Taking other prescription medications 0.8 1.2 4.3 -0.3 -1.0 -1.4 0.1 1.2 2.1 0.2 -1.1
Age when periods started (menarche) 0.3 0.8 1.4 -1.1 -1.0 -1.2 -1.2 -0.2 -0.2 -1.1 -0.5
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.4 -0.1 -0.0 0.5 -0.3 -0.4 -0.0 -0.3 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.8 0.3 0.3 -1.2 0.6 1.7 0.8 1.0 0.9
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 4.1 -0.1 0.3 0.1 0.5 -2.0 -1.5 0.5 0.3
Qualifications: CSEs or equivalent 1.2 1.5 3.3 -0.7 -1.0 -0.9 -1.4 0.3 1.7 -1.3 -1.8
Serious illness, injury or assault to yourself 1.9 2.3 3.6 -1.9 -1.4 -1.1 -1.9 1.0 0.4 -1.7 -1.9
High blood pressure 0.4 1.2 3.6 -1.9 -1.2 0.6 -0.9 -0.9 -0.9 -0.9 -1.1
Hayfever, allergic rhinitis or eczema 0.1 0.3 1.0 -0.1 0.5 -0.5 0.1 0.8 -0.4 0.2 1.0
Multivitamins +/- minerals 1.5 1.8 7.1 -1.0 -1.2 -0.9 -0.5 2.7 1.9 -0.6 -0.3
Stomach or abdominal pain in last month 0.7 0.8 1.8 -0.6 0.3 1.3 -1.3 0.3 0.2 -1.2 -1.1
Supplements: Glucosamine 0.9 1.1 3.9 0.4 0.3 -0.7 1.1 1.3 -0.6 1.0 2.0
Diverticular disease/diverticulitis (self-reported) 3.2 3.7 11.9 2.9 3.5 0.7 1.7 -0.8 -1.2 1.5 1.3
Medication: Atenolol 0.4 0.5 1.2 -1.1 -0.9 0.7 -0.7 0.9 -0.0 -0.4 -0.1
Medication: Levothyroxine sodium 0.6 1.0 2.3 0.8 1.5 1.0 0.9 -0.8 -1.3 0.7 0.0
Sitting height 0.7 5.3 8.2 -2.4 -2.9 -2.1 -2.8 -0.6 0.9 -2.7 -2.8
Chronic bronchitis/emphysema (father) 1.4 1.6 4.7 -1.0 -2.2 -1.4 -1.0 1.2 1.1 -0.8 -1.1
High blood pressure (mother) 0.2 0.2 0.5 -0.2 0.2 -0.7 -0.3 0.7 -0.3 -0.3 0.7
Body mass index (BMI) 0.2 0.7 2.1 0.4 0.1 0.7 1.5 -0.6 -0.2 1.5 0.6
Impedance of leg (left) 1.1 5.4 12.3 -3.5 -2.0 -0.3 -3.5 0.5 0.2 -3.1 -2.3
Leg predicted mass (left) 0.2 1.0 2.7 1.4 0.4 0.3 1.6 -1.1 -0.3 1.3 0.4
Trunk fat mass 0.1 0.6 2.2 -1.2 -1.5 0.5 0.3 -0.7 0.1 0.3 -0.7
Waist circumference 0.1 0.5 1.4 -1.0 -1.2 0.9 0.3 -0.6 -0.3 0.2 -0.6
Number of incorrect matches in round 1.1 1.8 4.8 1.2 0.5 0.1 2.1 0.5 0.6 2.2 1.6
Past tobacco smoking 2.3 4.3 10.0 1.6 2.1 1.7 1.9 -3.2 -2.7 1.6 0.9
Alcohol usually taken with meals 1.0 1.7 3.4 1.3 0.2 -1.8 0.7 1.8 1.8 0.9 0.6
Nervous feelings 0.4 0.8 2.7 0.9 -0.6 -1.6 0.4 0.5 1.3 0.4 0.1
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.2 6.9 -2.2 -2.6 -2.0 -1.1 2.0 1.9 -0.7 -0.5
Hearing difficulty/problems with background noise 1.7 2.7 5.5 -1.2 -1.7 -1.0 -1.4 2.4 2.3 -1.2 -1.4
Hair/balding pattern: Pattern 2 1.8 2.3 8.4 1.2 0.8 2.9 1.3 -2.1 -0.5 1.2 0.2
Had menopause 0.3 0.4 1.1 1.0 0.3 0.6 1.0 -0.5 -0.3 0.7 0.3
Had other major operations 1.5 1.8 2.9 -1.7 -1.6 -1.4 -1.6 0.2 0.4 -1.4 -1.5
Forced vital capacity (FVC) 0.4 1.5 5.8 1.4 1.3 -0.4 -0.0 -2.4 -1.4 -0.4 0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.9 0.5 0.1 -1.4 0.7 1.2 0.9 0.9 0.5
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 1.8 -0.7 -0.3 -1.4 -0.2 0.9 0.4 -0.0 0.3
Qualifications: None of the above 1.1 2.3 6.0 -2.4 -2.5 -1.3 -0.8 1.0 1.3 -0.5 -1.1
Financial difficulties in last 2 years 1.1 1.4 2.8 -1.7 -1.5 -1.7 -0.9 1.3 0.7 -0.6 -0.5
Mouth/teeth dental problems 0.7 1.1 2.9 0.9 1.1 -0.3 1.1 -0.9 -1.7 0.9 1.1
Heart attack 0.8 1.1 2.5 -1.5 -0.2 0.1 -1.6 1.3 0.1 -1.3 -0.8
Allergy 0.0 0.1 0.4 0.3 -0.3 0.1 -0.0 -0.6 0.1 -0.1 -0.4
Pain all over the body in last month 0.6 0.7 1.6 -1.3 -1.0 0.1 -0.9 0.7 0.8 -0.7 -0.4
Diabetes (self-reported) 1.4 2.2 5.7 -1.6 -2.4 -1.3 -1.5 0.2 0.8 -1.5 -1.6
Hayfever/allergic rhinitis (self-reported) 1.4 1.9 4.0 1.3 2.0 0.5 1.5 -0.2 -1.1 1.5 1.8
Medication: Ramipril 0.5 0.7 1.7 -0.9 -0.5 1.3 0.8 0.9 0.0 1.0 0.6
Medication: Simvastatin 0.6 0.9 3.3 -1.8 -1.4 -0.8 -0.7 0.0 -0.8 -0.6 -0.4
Fluid intelligence score 0.6 1.2 3.5 0.5 -0.5 -0.5 -1.2 -1.1 0.3 -1.9 -1.7
Illnesses of siblings 0.3 0.5 1.2 -0.9 0.2 1.0 -0.6 1.1 -0.3 -0.3 0.6
Neuroticism score 4.5 9.4 20.9 -3.3 -4.6 -2.4 -2.5 2.3 3.6 -2.4 -2.8
Weight 0.1 0.4 1.2 0.2 -0.6 0.1 1.1 -0.8 0.0 1.0 0.2
Impedance of arm (right) 0.2 1.0 1.9 -1.3 -1.3 -0.2 -1.2 0.0 0.2 -1.3 -1.4
Arm fat percentage (right) 0.1 0.6 1.8 0.1 -0.5 0.7 1.4 -0.5 0.1 1.3 0.1
Trunk fat-free mass 0.1 0.4 1.0 1.0 -0.3 -0.4 0.9 -0.5 0.3 0.6 0.4
Hip circumference 0.3 1.4 4.1 1.5 0.6 0.4 2.0 -0.6 -0.1 1.8 1.0
Time employed in main current job 1.2 1.4 4.8 2.2 0.8 0.3 1.7 -0.9 0.5 1.2 0.6
Alcohol intake versus 10 years previously 0.6 0.8 3.5 -0.2 0.9 1.9 -0.9 0.7 -0.6 -0.8 -0.5
Father’s age at death 3.8 5.0 8.9 2.8 3.0 1.7 2.4 -0.5 -1.3 2.4 2.7
Worrier / anxious feelings 1.2 2.2 6.2 -1.2 -2.5 -0.9 -0.9 1.8 2.0 -0.8 -0.8
Frequency of tiredness / lethargy in last 2 weeks 2.0 3.3 7.1 -2.6 -2.7 -0.4 -1.9 0.6 1.0 -1.7 -2.1
Falls in the last year 1.2 1.7 3.0 -1.4 -1.6 -1.7 -0.9 1.4 1.2 -1.1 -0.8
Hair/balding pattern: Pattern 3 0.7 1.1 1.8 -1.3 -0.3 -1.2 -1.4 0.3 -1.3 -1.1 -0.3
Number of live births 2.1 3.0 7.4 1.4 1.5 0.1 2.4 0.4 -0.3 2.7 2.5
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 2.9 1.7 1.6 -1.0 0.5 -0.9 -1.0 0.1 1.2
Pulse rate 0.7 1.2 6.7 -0.3 0.6 2.6 0.5 -0.8 -0.9 0.6 0.4
Happiness 2.2 2.7 10.0 0.6 -1.8 -1.4 -0.1 2.5 3.2 0.0 0.1
Noisy workplace 0.9 1.1 3.1 -1.8 -1.1 -0.3 -1.4 -0.6 -0.8 -1.2 -0.6
Qualifications: A levels/AS levels or equivalent 1.5 3.2 7.9 2.8 2.1 1.6 1.9 -1.1 -1.3 1.4 1.7
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 2.6 -1.2 -0.3 0.8 -1.5 -1.1 -1.0 -1.6 -1.1
Mouth/teeth dental problems: Dentures 0.9 1.6 4.9 -1.5 -2.2 -1.2 -0.5 1.5 1.2 -0.1 -0.2
Asthma 0.1 0.2 0.8 0.0 -0.6 -0.6 0.5 0.2 0.9 0.3 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.9 -0.9 -0.8 0.2 -0.3 0.0 0.7 -0.4 -0.2
Medication: Cholesterol lowering 1.1 1.8 3.1 -1.7 -1.3 -0.7 -1.6 -0.6 -0.5 -1.8 -1.7
Depression (self-reported) 3.2 3.8 7.5 -1.5 -1.4 -0.7 -2.2 1.4 2.7 -2.2 -2.6
Medication: Lansoprazole 1.0 1.2 4.0 -0.7 0.0 0.8 -1.2 0.6 0.8 -1.3 -2.0
Prospective memory result 0.5 0.7 2.2 -0.4 0.4 1.5 0.7 0.6 -0.2 1.0 1.0
Lung cancer (father) 0.6 0.6 3.7 -0.9 -0.4 1.9 -0.3 -0.2 0.3 -0.3 -0.5
Illnesses of mother 0.2 0.2 0.9 -0.1 -0.1 -0.4 -0.2 -1.0 -0.1 -0.3 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 3.1 1.7 1.8 -0.7 0.5 -0.9 -0.9 0.1 1.0
Pulse wave Arterial Stiffness index 2.0 2.4 6.5 -2.4 -2.5 -0.1 -1.5 -0.1 0.8 -1.5 -1.4
Impedance of arm (left) 0.5 2.2 4.3 -2.1 -1.5 -0.6 -1.9 -0.4 -0.4 -2.0 -1.7
Arm fat mass (right) 0.1 0.6 1.8 0.2 -0.5 0.5 1.4 -0.9 -0.1 1.3 0.1
Trunk predicted mass 0.1 0.4 1.0 1.0 -0.2 -0.4 0.9 -0.6 0.2 0.6 0.3
Standing height 0.1 1.2 3.3 -0.7 -1.8 -1.2 -0.9 -0.3 0.8 -1.2 -1.2
Length of working week for main job 0.5 0.5 1.0 -0.8 -1.0 0.3 -0.6 1.0 0.7 -0.3 -0.5
Exposure to tobacco smoke at home 0.8 0.9 3.7 -1.4 -1.9 0.2 -0.3 0.2 1.0 0.0 -0.5
Breastfed as a baby 1.3 1.6 9.8 -0.3 0.6 -0.7 0.1 -1.1 -3.1 -0.2 0.7
Tense / ‘highly strung’ 3.3 5.4 12.7 -2.8 -3.6 -1.3 -1.9 1.0 2.6 -1.6 -2.5
Seen doctor (GP) for nerves, anxiety, tension or depression 5.3 8.2 14.3 -2.4 -3.5 -3.5 -2.3 1.3 3.8 -2.3 -2.9
Hair/balding pattern: Pattern 4 0.6 1.4 4.5 0.6 -0.2 -1.7 0.2 2.1 1.7 0.4 0.9
Birth weight of first child 2.5 4.5 8.0 2.3 2.8 2.2 2.3 -0.4 -1.5 2.3 2.2
Peak expiratory flow (PEF) 0.4 0.9 3.3 0.8 0.8 -0.8 1.0 0.3 -0.6 0.8 1.8
Pulse wave reflection index 1.0 1.2 3.6 -0.2 -0.7 -1.8 -0.8 0.7 1.9 -0.7 -0.9
Ever highly irritable/argumentative for 2 days 3.5 4.2 8.0 -2.3 -2.3 -0.5 -1.9 1.7 2.8 -1.6 -2.4
Loud music exposure frequency 1.1 1.2 3.1 -0.8 -1.1 0.8 -1.3 -0.0 -0.1 -1.5 -1.8
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 3.0 1.0 1.6 1.7 0.4 -1.7 -1.1 0.0 0.1
Mouth/teeth dental problems: Bleeding gums 1.4 1.9 3.6 -1.5 -1.0 1.0 -1.7 -0.2 0.9 -1.8 -1.9
Blood clot in the leg (DVT) 0.5 0.7 2.0 -1.3 -0.3 1.4 -1.0 0.2 -0.1 -0.6 -0.8
Medication: Paracetamol 0.2 0.4 1.0 -0.4 -1.0 -0.1 -0.1 -0.4 0.8 -0.4 -1.0
Headache pain in last month 0.3 0.4 1.7 -0.9 -0.4 -0.1 -0.3 -1.3 -0.7 -0.4 -0.5
Medication for cholesterol, blood pressure or diabetes 1.4 2.2 5.0 2.2 1.3 0.1 1.9 0.7 0.6 1.9 1.8
Glaucoma (self-reported) 1.8 2.1 5.7 1.1 1.0 -0.2 2.4 0.2 0.4 2.4 1.8
Gout (self-reported) 0.9 1.2 4.2 -0.4 -1.1 -1.0 -0.2 2.0 1.8 0.2 0.3
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 5.9 0.1 1.4 1.5 0.3 -1.7 -2.4 0.2 -0.3
Medication: Amlodipine 0.4 0.6 1.7 -0.6 -0.6 -1.1 0.7 0.6 -0.2 0.5 1.3
Medication: Ventolin 100micrograms inhaler 0.6 0.7 2.1 -1.4 -0.7 0.8 -0.7 -0.5 -0.5 -0.5 -1.1
Birth weight 1.2 2.6 6.3 1.8 0.7 0.2 2.5 0.6 0.2 2.2 2.2
Chronic bronchitis/emphysema (mother) 2.3 2.7 5.3 -2.1 -2.3 -1.0 -2.1 -0.1 0.2 -2.0 -1.6
High blood pressure (siblings) 0.5 0.8 2.7 1.6 0.6 -0.4 0.9 0.4 1.1 0.7 0.4
Forced vital capacity (FVC), Best measure 0.4 1.4 5.4 1.5 1.5 -0.4 0.1 -2.3 -0.9 -0.4 -0.1
Body fat percentage 0.2 0.6 2.0 -1.4 -1.2 0.7 0.2 -0.5 -0.2 0.3 -0.7
Leg fat percentage (right) 0.1 0.5 1.9 -1.4 -0.7 1.0 0.1 -0.1 -0.2 0.3 -0.3
Arm fat-free mass (right) 0.1 0.3 1.1 0.6 -0.2 -0.3 0.8 -1.0 -0.1 0.5 0.2
Exposure to tobacco smoke outside home 1.3 1.7 4.5 -2.1 -1.6 0.1 -1.5 -0.8 -0.2 -1.4 -1.4
Comparative body size at age 10 0.3 1.0 2.4 1.1 0.3 0.1 1.5 -0.2 0.4 1.2 1.5
Number of full brothers 0.3 0.4 1.0 0.4 0.8 0.3 -0.1 -0.9 -0.4 -0.3 -1.0
Worry too long after embarrassment 2.9 4.9 11.9 -1.6 -3.4 -2.9 -0.9 1.6 3.3 -0.9 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 3.0 3.9 6.5 -2.2 -1.9 -2.1 -2.6 -0.1 0.1 -2.6 -2.3
Wheeze or whistling in the chest in last year 0.6 1.0 2.6 -1.1 -0.9 -0.2 -0.7 1.6 1.5 -0.4 -0.7
Number of children fathered 0.2 0.2 0.9 0.2 0.5 0.3 -0.1 0.9 0.3 0.1 0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.9 3.1 1.1 1.2 1.8 1.4 -0.6 -1.6 1.3 1.6
Age at first live birth 0.4 0.7 2.4 1.2 1.6 0.3 0.3 -0.2 -1.0 -0.2 0.2
Pulse wave peak to peak time 2.0 2.3 6.4 2.4 2.5 0.1 1.5 0.1 -0.7 1.4 1.2
Health satisfaction 0.2 0.3 1.1 0.7 0.7 1.0 0.2 -0.2 -0.3 0.2 0.3
Shortness of breath walking on level ground 1.0 1.2 3.5 -1.9 -0.9 0.9 -0.3 -1.5 -0.9 -0.4 -0.9
Qualifications: College or University degree 2.4 7.5 15.8 3.9 4.0 1.2 2.8 -0.7 -2.1 2.4 3.0
Eye problems/disorders: None of the above 0.1 0.2 0.8 -0.2 -0.1 -0.9 0.1 0.4 -0.2 0.3 0.5
Mouth/teeth dental problems: Loose teeth 0.5 0.6 2.0 0.0 1.4 0.0 -1.2 0.2 -0.6 -0.9 -0.4
Emphysema/chronic bronchitis 0.8 0.9 2.0 -0.3 1.0 1.2 -0.5 -1.4 -0.9 -0.2 -1.1
Medication for pain relief, constipation, heartburn 0.4 0.6 2.8 0.9 1.7 0.2 -0.1 -0.5 -1.0 0.0 0.4
Neck or shoulder pain in last month 0.9 1.3 3.1 -1.8 -1.6 -0.4 -0.7 -0.4 0.6 -0.8 -1.7
Medication: Blood pressure 2.0 3.6 8.1 -2.8 -1.5 1.1 -2.4 -0.6 -0.1 -2.2 -2.5
Angina (self-reported) 0.2 0.3 0.6 0.2 0.2 0.1 0.8 0.6 -0.4 0.7 0.7
Migraine (self-reported) 0.5 0.6 1.6 0.9 0.9 0.3 -0.1 -1.1 0.3 -0.3 -1.3
Medication: Ibuprofen 0.3 0.4 0.8 -0.9 -0.8 0.2 -0.3 -0.8 0.3 -0.5 -0.7
Medication: Allopurinol 0.7 0.9 2.5 -0.2 -0.9 -0.9 0.4 1.6 1.2 0.7 0.9
Medication: Omeprazole 0.3 0.3 0.8 -0.5 0.1 0.8 -0.9 0.3 -0.4 -0.7 -0.5
Medication: Seretide 50 evohaler 1.0 1.2 3.0 -1.1 -1.7 -0.3 -1.0 -0.1 1.2 -1.0 -1.4
Mean time to correctly identify matches 0.9 1.8 5.7 -1.0 -2.0 -1.2 -0.1 2.4 1.2 0.5 0.6
Heart disease (mother) 0.5 0.6 2.3 0.5 0.4 1.0 -0.0 -1.5 -1.0 -0.3 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.1 0.1 0.7 0.4 0.3 1.4 1.1 0.8 0.8
Whole body fat mass 0.1 0.4 1.2 -0.8 -1.1 0.6 0.5 -0.4 0.2 0.5 -0.5
Leg fat mass (right) 0.1 0.4 0.9 -0.4 -0.4 0.8 0.9 -0.4 -0.1 1.0 0.1
Arm predicted mass (right) 0.1 0.3 1.5 0.3 -0.4 -0.2 0.5 -1.2 -0.2 0.3 -0.1
Pulse rate, automated reading 1.9 6.0 15.3 1.3 3.0 3.9 1.2 -3.1 -3.3 1.0 0.4
Alcohol intake frequency. 0.5 1.1 5.6 -0.5 0.2 0.2 -0.5 -2.4 -0.9 -0.4 -1.1
Comparative height size at age 10 0.1 0.4 1.3 -0.8 -1.2 -0.8 0.2 -0.0 0.6 0.1 -0.3
Number of full sisters 0.7 0.8 2.3 -1.5 -0.8 0.4 -0.6 -0.8 -1.4 -0.7 -0.3
Suffer from ‘nerves’ 1.2 1.8 2.8 -1.6 -1.6 -1.7 -1.3 0.8 1.4 -1.1 -1.2
Overall health rating 2.1 4.5 10.3 -2.3 -1.5 -0.4 -2.3 -2.6 -0.8 -2.4 -3.2
Chest pain or discomfort 0.7 0.9 2.8 -1.3 -1.5 0.4 -0.4 -0.3 0.6 -0.5 -1.7
Had major operations 2.8 3.3 5.4 -1.6 -1.9 -1.4 -2.3 1.7 1.5 -2.2 -1.6
Age at last live birth 0.4 0.5 1.8 -0.0 1.3 0.5 -0.2 -0.7 -1.2 -0.3 0.1
Family relationship satisfaction 1.7 2.2 6.0 -0.8 -1.6 -1.1 -0.8 2.4 2.4 -0.5 -0.4
Leg pain on walking 0.5 0.6 2.1 -1.5 -1.0 0.4 -0.8 0.4 -0.4 -0.6 -0.0
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 1.0 -1.0 -0.6 -0.4 -0.4 -0.1 -0.2 -0.4 -0.3
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.9 0.0 0.6 1.0 -0.5 0.3 0.1 -0.5 -0.1
Illness, injury, bereavement, stress in last 2 years 2.8 3.4 7.2 2.7 1.9 1.5 2.2 -1.5 -1.0 1.9 1.6
Medication: Aspirin 0.1 0.1 0.6 -0.8 -0.5 0.1 -0.1 0.1 -0.4 -0.2 -0.3
Supplements: Vitamin C 0.5 0.6 1.8 -0.7 -1.3 -0.3 -0.5 0.4 1.3 -0.4 -0.4
Knee pain experienced in last month 0.6 1.0 2.1 0.2 1.4 1.5 0.5 -1.4 -1.1 0.4 -0.4
Hypertension (Self-reported) 0.5 1.3 3.8 -1.9 -1.6 0.4 -1.1 -0.5 -0.4 -1.1 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 2.7 1.6 1.6 0.7 0.1 -0.1 1.0 0.0 -1.0
Illnesses of father: Heart disease 0.2 0.3 1.1 0.0 0.3 1.1 -0.2 -0.1 -0.7 -0.3 0.6
Illnesses of siblings: Diabetes 1.1 1.4 3.2 -0.7 -1.2 -1.1 -0.7 -1.6 -0.2 -1.3 -1.8
Smoking status: Previous 2.1 3.1 10.4 -0.8 -1.5 -0.7 -0.9 3.2 3.1 -0.6 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 1.4 3.0 5.6 -1.8 -2.0 -0.8 -2.3 0.2 0.7 -2.4 -2.1
Whole body fat-free mass 0.1 0.5 1.4 1.2 0.0 0.0 1.2 -0.7 0.2 0.9 0.3
Leg fat-free mass (right) 0.2 0.9 2.6 1.5 0.3 0.1 1.6 -0.8 0.3 1.3 0.4
Arm fat percentage (left) 0.1 0.4 1.0 -0.3 -0.5 0.6 1.0 -0.8 -0.4 1.0 -0.0
Average weekly red wine intake 0.4 0.6 1.4 -0.8 -1.2 0.2 -1.0 0.7 0.4 -1.1 -0.4
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.8 -0.2 -0.7 -1.3 -0.2 -0.0 -0.0 -0.3 -0.2
Mood swings 2.2 4.0 9.4 -1.4 -2.5 -0.9 -1.5 2.1 3.1 -1.4 -2.3
Loneliness, isolation 1.8 2.5 7.4 -1.3 -2.7 -1.1 -1.0 0.3 1.9 -1.2 -1.7
Long-standing illness, disability or infirmity 1.6 2.4 6.8 -1.8 -0.7 0.7 -1.5 -1.6 -1.1 -1.6 -2.6
Ever had bowel cancer screening 0.6 0.7 2.9 0.6 1.3 1.7 0.2 0.4 -0.0 0.1 0.5
Diabetes diagnosed by doctor 1.5 2.4 5.5 -2.0 -2.3 -1.0 -1.7 0.0 0.4 -1.7 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.3 0.7 -0.4 0.1 0.5 -0.5 -0.3 0.6 -0.4 -0.8
Friendships satisfaction 2.1 2.6 8.6 -0.3 -1.1 -1.9 -0.8 2.9 2.5 -0.5 -0.4
Qualifications: nursing, teaching 0.6 1.0 2.2 1.5 1.1 1.0 0.8 -1.5 -0.3 0.4 0.5
Commuting to job workplace: Walk 0.9 0.9 2.3 -0.8 -1.3 -1.5 -0.9 -0.1 0.7 -0.8 -0.9
Eye problems/disorders: Cataract 0.9 1.0 5.5 0.3 0.7 2.3 -0.0 -0.7 -1.1 -0.3 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.7 1.0 3.0 1.4 1.2 1.7 0.8 0.6 0.5 0.8 0.2
Medication for cholesterol 0.5 0.8 2.2 0.6 1.5 0.2 0.7 -0.4 -0.8 0.8 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.2 -0.3 -0.4 0.7 -0.4 -1.1 -1.0 -0.6 0.1
Back pain experienced in last month 0.6 0.8 2.0 -1.0 -0.7 -1.4 -0.9 -0.4 0.2 -1.1 -1.0
Mineral and other dietary supplements 0.2 0.2 0.7 0.9 0.4 0.1 0.3 -0.0 0.8 0.5 0.3
Breast cancer (self-reported) 0.6 0.7 2.2 1.5 0.7 0.2 0.2 -0.2 1.3 -0.0 -1.2
Asthma (self-reported) 0.1 0.2 0.9 -0.0 -0.4 -0.4 0.4 0.3 1.0 0.2 -0.4
Osteoporosis (self-reported) 0.3 0.3 1.1 0.6 0.5 1.1 -0.3 0.2 -0.1 -0.7 -0.4
Osteoarthritis (self-reported) 1.2 1.6 3.6 0.8 1.5 1.2 0.9 -1.9 -1.7 0.8 0.3
Medication: Aspirin 0.1 0.1 0.5 -0.4 -0.1 0.1 0.4 -0.2 -0.7 0.2 0.3
Medication: Gliclazide 1.2 1.4 4.9 -0.6 -0.9 -0.5 0.8 2.2 -0.2 1.3 1.5
Illnesses of father: None of the above (group 1) 0.2 0.2 0.9 -0.4 0.0 0.6 0.2 -1.0 -0.5 0.1 -0.0
Smoking status: Current 3.6 5.7 12.2 -3.5 -3.0 -1.5 -3.2 0.9 0.6 -2.8 -1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 5.8 1.3 0.0 -2.4 1.0 0.6 0.1 1.1 2.0
Whole body water mass 0.1 0.7 1.8 1.3 0.1 -0.2 1.3 -0.8 0.2 1.0 0.4
Leg predicted mass (right) 0.2 1.0 2.9 1.5 0.3 0.1 1.7 -0.8 0.2 1.4 0.5
Arm fat mass (left) 0.1 0.5 1.3 0.0 -0.5 0.5 1.1 -0.9 -0.1 1.1 -0.1
Number of self-reported non-cancer illnesses 1.0 1.8 4.9 -1.8 -1.6 -0.0 -1.3 -0.4 0.7 -1.3 -2.2
Average weekly champagne plus white wine intake 1.8 2.4 6.6 2.5 2.6 0.4 1.6 0.4 -0.8 1.4 1.1
Miserableness 3.0 5.2 11.4 -1.8 -3.2 -2.2 -1.3 2.7 3.4 -1.0 -1.4
Guilty feelings 2.1 3.1 7.3 -1.7 -2.7 -2.4 -1.4 0.8 1.5 -1.4 -1.5
Wears glasses or contact lenses 1.0 1.2 2.7 -0.9 -1.1 0.1 -1.1 -1.0 0.5 -1.6 -1.7
Ever taken oral contraceptive pill 2.4 2.6 5.3 -2.0 -1.4 -2.3 -1.9 0.9 -0.5 -1.9 -1.1
Hearing aid user 0.7 0.8 3.4 -0.2 -0.8 -0.9 -0.3 0.8 1.8 -0.1 -0.7
Mother’s age at death 3.2 4.0 8.0 1.9 2.0 -0.6 2.0 2.5 0.4 2.4 2.8
Financial situation satisfaction 1.2 1.4 6.1 0.1 -1.2 -1.0 -0.2 1.6 2.5 -0.0 -0.5
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.7 0.1 -0.1 0.3 -0.7 -0.1 -0.6 -0.9 -0.4
Commuting to job workplace: Public transport 1.4 1.6 7.9 0.1 0.3 -0.8 0.3 2.8 1.9 0.7 0.6
Eye problems/disorders: Glaucoma 0.8 1.0 2.4 1.0 0.8 -0.3 1.1 0.8 1.5 1.2 0.6
Medication: Blood pressure 0.1 0.2 0.9 -0.2 -0.1 0.3 0.3 1.0 0.4 0.4 0.0
Pain type(s) experienced in last month: Hip pain 1.0 1.3 3.1 -1.8 -1.3 -0.7 -1.2 0.6 1.2 -1.0 -1.1
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.2 -1.5 -1.1 -0.5 -0.8 -0.4 -0.2 -0.9 -0.9
High cholesterol (Self-reported) 0.7 1.2 2.9 -1.0 -1.7 -0.0 -1.2 -0.4 0.0 -1.5 -1.5
Medication: Bendroflumethiazide 0.5 0.8 3.7 -0.6 0.1 1.9 0.2 -1.0 -0.6 0.1 -0.7
Medication: Paracetamol 0.3 0.5 1.5 -0.0 -0.5 -0.2 0.1 -1.1 0.6 -0.4 -1.2
Medication: Lisinopril 0.3 0.4 1.6 -1.2 -0.9 -0.2 -0.7 0.4 0.0 -0.4 -0.2
Medication: Atorvastatin 2.7 3.3 8.1 -1.8 -2.1 -0.3 -2.3 -0.3 -0.2 -2.9 -2.3
Illnesses of father: High blood pressure 0.3 0.3 1.4 0.6 1.2 0.4 0.3 0.3 0.1 0.5 0.4
Alcohol drinker status: Never 2.3 2.8 4.4 1.5 1.6 -0.2 2.0 -1.7 -1.7 1.8 2.1
Ever smoked 1.8 3.1 6.3 -1.1 -2.0 -2.5 -1.5 2.3 1.9 -1.4 -0.3
Basal metabolic rate 0.1 0.5 1.7 1.0 -0.1 -0.1 1.3 -0.7 0.2 1.0 0.4
Leg fat percentage (left) 0.1 0.5 1.9 -1.4 -0.7 1.0 0.2 0.1 -0.0 0.4 -0.2
Arm fat-free mass (left) 0.2 0.9 2.2 1.5 0.3 0.2 1.4 -1.0 0.2 1.2 0.3
Number of operations (self-reported) 0.9 1.3 2.8 -1.0 -1.0 -0.5 -1.7 1.0 0.3 -1.5 -1.4
Average weekly beer plus cider intake 0.5 0.7 1.6 -1.0 -0.4 -0.1 -1.1 0.1 0.8 -0.8 -1.3
Irritability 5.6 9.5 14.6 -3.1 -3.8 -2.2 -3.2 1.6 3.6 -3.1 -3.4
Risk taking 1.2 1.8 3.7 -1.5 -0.9 -0.9 -1.7 -0.1 0.2 -1.8 -1.9
Ever had prostate specific antigen (PSA) test 1.8 2.0 7.3 -2.7 -1.7 -0.8 -1.3 1.4 0.9 -0.9 -0.5
Fractured/broken bones in last 5 years 0.3 0.4 0.7 0.0 0.7 0.6 0.4 0.8 -0.6 0.6 0.8
Age started oral contraceptive pill 2.0 2.6 6.3 2.5 1.2 0.7 2.4 -0.4 -0.0 2.0 1.5
Diastolic blood pressure, automated reading 0.9 2.7 6.7 1.5 2.5 1.7 0.4 -2.6 -1.9 0.0 -0.3
Ever depressed for a whole week 0.7 0.9 3.8 -0.8 -1.0 -1.9 -0.4 0.5 0.9 -0.5 -0.4
Unable to work because of sickness or disability 1.6 2.1 4.5 -2.1 -1.7 -0.6 -1.9 0.5 0.9 -1.6 -1.4
Commuting to job workplace: Cycle 1.0 1.2 3.6 1.0 0.2 -1.9 1.1 -0.2 0.2 1.0 1.5
Myopia 0.7 1.0 3.5 -0.8 -1.0 -1.9 -0.7 1.4 0.5 -0.5 0.1
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.6 1.3 0.9 -0.1 0.4 0.8 0.9 0.5 0.7
Cholesterol lowering medication 0.9 1.3 4.3 -1.6 -2.1 -0.3 -1.0 1.1 0.0 -1.0 -0.6
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 1.0 0.3 0.6 1.0 -0.3 0.0 -0.0 -0.2 -0.5
Pain experienced in last month 0.4 0.7 2.1 1.5 1.0 0.0 0.5 0.2 -0.9 0.5 1.1
Supplements: Calcium 0.9 1.0 1.5 -1.2 -0.9 1.1 -0.7 -0.7 -1.1 -0.9 -1.2
Basal cell carcinoma (self-reported) 0.3 0.4 1.0 -0.1 -0.6 -1.0 0.1 -1.0 0.3 -0.0 -0.7
Heart attack/myocardial infarction (self-reported) 0.8 1.0 2.3 -1.4 -0.1 0.1 -1.5 1.4 0.2 -1.2 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.6 -1.0 -0.3 1.3 -0.8 0.2 0.3 -0.5 -0.7
Heart disease (siblings) 1.5 1.9 3.4 -1.8 -1.9 -0.6 -1.4 -1.2 -1.1 -1.4 -1.3
Alcohol drinker status: Previous 0.1 0.1 0.5 -0.7 -0.4 -0.0 -0.0 0.1 -0.1 0.0 -0.1
Pack years of smoking 2.6 3.8 9.6 -2.0 -1.7 0.5 -2.1 -1.9 0.0 -2.3 -3.1
Impedance of whole body 0.9 4.4 9.5 -3.1 -1.9 -0.5 -2.9 0.0 -0.1 -2.8 -2.2
Leg fat mass (left) 0.1 0.4 1.2 -0.3 -0.3 0.9 1.0 -0.4 -0.2 1.1 0.2
Arm predicted mass (left) 0.2 0.8 2.0 1.4 0.3 0.3 1.4 -0.8 0.3 1.2 0.4