Best TWAS P=1.1e-08 · Best GWAS P=3.69e-08 conditioned to 0.2
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | GNL3 | 0.08 | 0.06 | lasso | 3 | 0.06 | 3.0e-05 | 4.8 | 5.1 | 3.0e-07 | 0.89 | 0.15 | 0.84 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | NT5DC2 | 0.13 | 0.12 | enet | 11 | 0.08 | 9.9e-05 | 5.5 | 5.6 | 2.0e-08 | 0.95 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | NT5DC2 | 0.09 | 0.08 | lasso | 1 | 0.06 | 5.9e-03 | 5.5 | 5.5 | 4.3e-08 | 0.99 | 0.02 | 0.78 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | ITIH4-AS1 | 0.11 | 0.05 | enet | 10 | 0.02 | 5.1e-02 | 5.5 | -5.7 | 1.1e-08 | -0.84 | 0.02 | 0.90 | TRUE |
| 5 | GTEx | Cells EBV-transformed lymphocytes | RP5-966M1.6 | 0.16 | 0.07 | enet | 19 | 0.11 | 1.8e-04 | -4.7 | -5.5 | 3.5e-08 | -0.91 | 0.04 | 0.96 | FALSE |
| 6 | GTEx | Lung | GLYCTK | 0.12 | 0.09 | lasso | 6 | 0.08 | 1.5e-06 | 4.7 | 5.3 | 9.9e-08 | 0.76 | 0.03 | 0.97 | FALSE |
| 7 | GTEx | Lung | GLYCTK-AS1 | 0.11 | 0.09 | lasso | 5 | 0.09 | 3.0e-07 | 4.7 | 5.2 | 2.1e-07 | 0.81 | 0.03 | 0.97 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | NEK4 | 0.04 | 0.05 | blup | 359 | 0.05 | 1.1e-06 | 4.8 | 5.4 | 6.5e-08 | 0.90 | 0.09 | 0.91 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | GNL3 | 0.15 | 0.23 | enet | 16 | 0.22 | 2.0e-28 | 4.8 | 5.2 | 2.2e-07 | 0.91 | 0.12 | 0.88 | FALSE |
| 10 | YFS | Blood | GNL3 | 0.02 | 0.03 | enet | 11 | 0.03 | 2.9e-09 | -4.3 | 5.2 | 1.6e-07 | 0.88 | 0.41 | 0.58 | FALSE |
| 11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ITIH4 | 0.04 | 0.03 | blup | 53 | 0.03 | 7.4e-04 | -4.7 | -5.5 | 3.1e-08 | -0.86 | 0.03 | 0.87 | FALSE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | ITIH4 | 0.08 | 0.09 | blup | 53 | 0.08 | 3.1e-05 | -4.7 | -5.2 | 2.1e-07 | -0.69 | 0.14 | 0.81 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ITIH4 | 0.23 | 0.01 | enet | 7 | 0.02 | 1.6e-02 | -4.3 | -5.7 | 1.3e-08 | -0.71 | 0.03 | 0.95 | FALSE |
| 14 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ITIH4 | 0.05 | 0.02 | blup | 53 | 0.02 | 1.1e-02 | -4.7 | -5.5 | 2.9e-08 | -0.79 | 0.05 | 0.54 | FALSE |
| 15 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ITIH4 | 0.12 | 0.09 | blup | 53 | 0.06 | 1.4e-02 | -4.1 | -5.2 | 2.4e-07 | -0.88 | 0.02 | 0.56 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | ITIH4 | 0.20 | 0.12 | enet | 8 | 0.16 | 6.0e-15 | -4.7 | -5.3 | 1.0e-07 | -0.53 | 0.14 | 0.85 | FALSE |