Hub : Genes

GLYCTK

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.1402 0.0751 4.6e-03 0.048 NA 0.055 NA 0.047 7.8e-03 NA 4.8e-03 NA 8.4e-03
2 GTEx Artery Tibial 0.0359 0.0196 4.2e-03 0.022 NA 0.010 NA 0.000 7.2e-03 NA 4.9e-02 NA 2.9e-01
3 GTEx Brain Cerebellum 0.1520 0.0620 7.8e-05 0.099 NA 0.096 NA 0.113 7.4e-04 NA 8.8e-04 NA 3.2e-04
4 GTEx Brain Hippocampus 0.1668 0.0742 1.1e-03 0.156 NA 0.043 NA 0.099 1.7e-04 NA 3.7e-02 NA 2.6e-03
5 GTEx Cells Transformed fibroblasts 0.1940 0.0720 1.6e-05 0.027 NA 0.054 NA 0.046 3.9e-03 NA 6.4e-05 NA 2.3e-04
6 GTEx Esophagus Mucosa 0.1060 0.0470 6.8e-06 0.112 NA 0.083 NA 0.099 6.5e-08 NA 3.5e-06 NA 3.8e-07
7 GTEx Esophagus Muscularis 0.0880 0.0380 6.8e-06 0.105 NA 0.077 NA 0.083 6.1e-07 NA 2.0e-05 NA 9.7e-06
8 GTEx Heart Atrial Appendage 0.0770 0.0440 1.6e-03 0.025 NA -0.002 NA 0.000 2.7e-02 NA 4.1e-01 NA 3.0e-01
9 GTEx Lung 0.1230 0.0558 1.2e-06 0.093 NA 0.066 NA 0.077 1.4e-07 NA 9.6e-06 NA 1.6e-06
10 GTEx Skin Not Sun Exposed Suprapubic 0.0740 0.0430 2.2e-03 0.014 NA 0.058 NA -0.004 5.4e-02 NA 3.9e-04 NA 6.2e-01
11 GTEx Spleen 0.5600 0.1350 1.5e-07 0.144 NA 0.126 NA 0.088 1.6e-04 NA 4.1e-04 NA 2.9e-03
12 GTEx Testis 0.0980 0.0480 5.9e-03 0.051 NA 0.027 NA 0.032 2.7e-03 NA 2.3e-02 NA 1.4e-02
13 GTEx Thyroid 0.1290 0.0460 4.1e-10 0.188 NA 0.152 NA 0.168 2.6e-14 NA 9.6e-12 NA 7.1e-13
14 ROSMAP Brain Pre-frontal Cortex 0.0482 0.0199 9.0e-08 0.085 0.068 0.070 0.068 0.079 5.2e-11 4.6e-09 2.3e-09 4.6e-09 2.5e-10
15 YFS Blood 0.1485 0.0388 0.0e+00 0.135 0.113 0.134 0.131 0.133 6.4e-42 6.3e-35 1.1e-41 1.1e-40 2.5e-41
16 TCGA Brain Lower Grade Glioma 0.1111 0.0516 1.1e-05 0.047 0.039 0.043 NA 0.039 3.9e-06 2.7e-05 1.0e-05 NA 3.0e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bipolar Disorder (2018) 9.8 15.6 22.8 3.0 4.5 -4.2 4.2 3.4 4.3 4.4 4.2 4.8 4.1 4.2 2.3 4.2 4.4 4.2 -0.9
Bipolar Disorder or Schizophrenia 14.0 34.1 51.4 4.3 6.6 -6.5 6.2 5.1 6.4 6.4 6.0 7.2 6.0 6.4 2.6 6.4 6.4 6.4 -1.2
Depressed Affect (Nagel 2018) 1.0 2.1 4.4 0.1 1.6 -1.1 1.8 0.6 1.5 1.8 2.1 1.1 1.9 1.4 1.0 1.5 1.5 1.4 1.6
Depression (Nagel 2018) 3.7 5.6 10.8 2.1 2.5 -2.5 2.9 2.1 2.3 2.9 3.3 2.3 2.4 2.3 1.1 2.4 2.3 2.5 -1.1
Intelligence (Savage-Jansen 2018) 5.7 17.6 37.2 -3.4 -4.5 3.9 -6.1 -2.1 -4.2 -5.1 -6.0 -5.1 -4.2 -4.4 -1.4 -4.3 -4.0 -3.9 0.3
Neuroticism (Nagel 2018) 6.3 14.9 24.5 2.6 4.3 -3.8 4.4 1.7 4.1 4.6 4.9 4.2 4.8 4.1 2.2 4.1 4.1 4.2 0.5
Schizophrenia (2018) 9.0 18.6 28.4 2.9 4.8 -5.0 4.6 3.8 4.8 4.8 4.3 5.3 4.4 4.8 1.5 4.9 4.7 4.7 -0.8
Schizophrenia vs Biploar Disorder 0.1 0.1 0.6 0.4 -0.0 -0.4 0.1 -0.2 0.2 -0.2 -0.5 -0.2 -0.4 0.2 -0.8 0.3 0.1 0.1 0.5
Worry (Nagel 2018) 17.0 35.9 51.1 5.0 6.7 -6.4 6.3 3.5 6.5 6.8 7.1 7.1 6.8 6.5 2.6 6.5 6.5 6.4 -1.2
Alzheimer’s Disease (in mother) 0.4 0.5 1.8 0.1 0.8 -0.5 0.7 -1.4 0.7 0.7 0.4 0.9 0.2 0.5 0.4 0.7 0.7 0.5 0.7
Alzheimer’s Disease (in father) 0.3 0.4 1.2 0.2 0.5 -1.1 1.1 -0.0 0.4 0.4 0.0 0.6 -0.1 0.5 -1.0 0.5 0.4 0.5 0.8
Alzheimer’s Disease (including proxy) 0.5 0.8 2.0 0.0 0.9 -1.2 1.4 -1.1 0.8 0.8 0.7 1.1 0.3 0.7 -0.4 0.7 0.8 0.6 1.4
Crohns Disease (2017) 0.2 0.5 1.6 1.3 0.5 -1.1 0.7 0.2 0.5 0.5 1.2 0.4 1.0 0.4 -0.6 0.5 0.4 0.4 0.6
Irritable Bowel Disease (IBD) 0.9 2.1 3.7 1.6 1.5 -1.7 1.4 0.6 1.5 1.5 1.8 1.7 1.9 1.4 0.7 1.5 1.4 1.4 0.3
Ulcerative Colitis (UC) 0.9 1.6 3.0 0.8 1.4 -1.2 1.1 0.6 1.4 1.3 1.4 1.6 1.7 1.4 1.2 1.4 1.4 1.4 0.1
Major Depression (MDD) 2.8 3.4 7.9 1.3 1.8 -2.1 2.8 1.6 1.4 2.3 2.3 2.3 2.3 1.7 -0.2 1.6 1.5 1.9 -0.0
Reaction Time 0.2 0.4 2.3 -1.1 0.2 -0.3 0.5 1.5 0.2 0.0 0.1 0.2 0.5 0.0 -1.1 0.1 0.1 0.2 0.6
Verbal and Numeric Reasoning (VNR) 6.2 14.8 24.8 -3.4 -4.3 3.9 -4.9 -2.5 -4.0 -4.5 -5.0 -4.5 -3.9 -4.1 -0.8 -4.0 -4.0 -3.8 1.4
Breast Cancer 0.8 1.8 3.2 -1.2 -1.5 1.8 -1.6 -0.7 -1.4 -1.5 -1.2 -1.5 -1.7 -1.4 0.6 -1.4 -1.4 -1.3 0.5
Ovarian Cancer 0.4 0.5 2.3 0.4 0.5 -0.1 0.6 1.2 0.4 0.5 0.8 0.5 0.2 0.5 1.2 0.4 0.4 0.7 -1.5
Prostate Cancer 1.0 1.4 2.7 1.4 1.2 -1.0 1.3 0.7 1.1 1.5 1.6 1.2 1.5 1.3 0.4 1.3 1.1 1.0 -0.1
Age at First Birth 2.9 4.2 8.1 -1.6 -2.1 1.4 -2.7 -0.7 -2.1 -2.4 -2.8 -2.2 -2.5 -2.0 -2.1 -2.2 -2.0 -2.0 -0.6
Bipolar Disorder (2011) 10.2 9.9 22.1 2.6 3.5 -2.8 4.7 1.8 3.2 3.6 4.2 3.9 3.1 3.1 1.2 3.1 3.2 2.9 0.5
Body Mass Index (BMI) (2010) 0.3 0.4 2.3 0.0 -0.4 0.6 -1.5 -1.1 -0.2 -0.4 -0.4 -0.5 -0.4 -0.3 1.2 -0.2 -0.2 -0.2 -0.3
Coronary Artery Disease (CAD) 0.2 0.2 0.7 -0.8 -0.4 0.1 -0.6 -0.9 -0.3 -0.5 -0.1 -0.1 -0.8 -0.2 -0.1 -0.4 -0.3 -0.4 -0.5
Crohns Disease (2012) 0.3 0.5 1.5 1.2 0.6 -0.9 0.7 1.0 0.4 0.7 1.1 0.4 1.2 0.4 -0.3 0.4 0.4 0.5 0.2
Mean Putamen Volume 0.7 0.8 1.8 1.0 0.9 -1.2 1.3 0.6 0.7 0.6 1.2 0.7 0.9 0.7 -0.6 0.5 0.9 0.8 -0.6
Fasting Glucose 0.5 0.6 3.7 -0.7 0.1 0.8 -1.0 -0.3 0.3 0.1 -0.2 0.3 0.3 0.1 1.7 0.3 0.3 0.2 -1.9
HbA1C 0.1 0.2 1.1 0.7 0.1 -0.4 0.2 -1.0 0.1 -0.0 -0.5 0.0 0.2 0.1 -0.6 0.1 0.1 -0.1 0.3
HDL Cholesterol 2.3 3.8 17.4 -1.2 -1.7 1.1 0.9 -2.4 -2.0 -1.8 -0.2 -1.7 -1.1 -2.0 -2.0 -2.1 -2.0 -2.1 4.2
LDL Cholesterol 2.1 3.3 10.7 -2.2 -1.8 1.6 -3.3 1.0 -1.5 -1.8 -2.4 -1.9 -1.2 -1.4 -0.6 -1.5 -1.6 -1.3 -2.2
Lupus 0.1 0.1 0.4 -0.3 -0.2 0.2 -0.4 0.2 -0.3 -0.0 0.3 -0.6 0.3 -0.2 0.0 -0.1 -0.3 -0.0 -0.4
Neuroticism (2016) 5.4 7.8 11.2 2.4 3.4 -3.0 2.5 1.3 3.2 3.2 3.2 3.1 2.7 3.0 1.9 3.1 3.3 3.1 0.6
Primary Biliary Cirrhosis 1.5 2.1 3.5 -1.4 -1.6 1.0 -1.9 -0.6 -1.5 -1.7 -1.9 -1.8 -1.5 -1.4 -1.0 -1.5 -1.5 -1.4 -0.6
Rheumatoid Arthritis 1.7 2.3 6.2 -1.2 -1.5 0.3 -1.1 -0.9 -1.5 -1.7 -1.8 -1.7 -2.2 -1.3 -2.5 -1.5 -1.5 -1.6 0.1
Schizophrenia (2014) 11.3 24.9 39.2 3.1 5.5 -5.6 5.1 5.0 5.5 5.3 5.0 6.3 5.1 5.5 2.4 5.5 5.4 5.5 -1.5
Triglycerides 1.9 3.1 9.1 1.2 1.6 -0.3 -0.5 1.9 1.8 1.6 0.7 1.7 1.6 1.7 3.0 1.8 1.8 1.9 -2.8
Type 2 Diabetes (T2D) (2012) 5.6 6.4 8.9 2.5 2.8 -2.7 1.6 2.0 2.9 2.5 2.1 2.8 2.6 3.0 1.5 2.9 2.9 3.0 -1.9
Ulcerative Colitis 2.5 3.7 5.9 1.7 2.1 -1.9 2.3 0.7 2.0 2.2 2.4 2.2 2.4 2.0 0.8 2.0 2.0 2.0 0.4
Blood Eosinophil Count 1.1 8.7 23.3 -3.8 -2.9 2.5 -4.8 -0.1 -2.6 -3.4 -4.2 -3.1 -3.0 -2.5 -0.9 -2.7 -2.7 -2.5 -1.9
Blood Platelet Count 3.1 36.3 50.0 -7.1 -6.8 6.7 -6.6 -2.8 -6.5 -7.0 -6.8 -6.3 -6.0 -6.6 -3.0 -6.5 -6.5 -6.4 0.1
Blood Red Count 5.1 49.0 74.3 7.4 8.0 -7.5 7.5 3.9 7.7 8.1 7.5 8.6 5.7 7.8 3.7 7.8 7.7 7.0 -2.4
Blood White Count 0.2 1.7 13.2 1.1 0.0 1.0 -1.6 1.2 0.2 0.0 -0.8 0.6 -1.1 0.4 2.3 0.2 0.2 0.3 -3.6
Heel T-Score 0.1 1.1 3.6 1.0 -0.9 0.4 -1.9 -1.3 -0.5 -1.3 -1.2 -1.0 -1.5 -0.5 -0.4 -0.6 -0.5 -0.8 -1.5
BMI 4.0 23.2 43.8 -3.6 -4.7 5.8 -6.6 -5.5 -4.2 -4.8 -6.2 -5.5 -5.8 -4.4 1.9 -4.2 -4.1 -4.5 3.1
Height 3.0 57.4 148.8 7.4 8.0 -8.1 12.2 2.0 7.0 8.8 11.0 7.5 8.2 6.8 1.0 7.0 7.0 6.6 4.5
Waist Hip Ratio (WHR) 19.0 85.7 112.4 7.5 10.0 -9.0 6.5 10.4 9.9 9.7 8.6 10.6 8.7 10.3 6.8 9.9 9.9 10.4 -8.4
Systolic Blood Pressure 2.3 11.6 21.8 -4.2 -3.8 3.8 -4.3 -1.3 -3.5 -3.9 -4.7 -3.4 -3.2 -3.5 -1.4 -3.5 -3.5 -3.1 -0.5
Smoking Status 5.5 13.1 25.5 -4.3 -4.0 4.7 -5.0 -0.3 -3.7 -4.0 -3.9 -4.2 -3.0 -3.7 0.2 -3.7 -3.7 -3.3 -1.2
Allergy or Eczema 0.2 0.5 1.5 0.7 0.8 -0.8 1.2 -0.1 0.6 0.7 0.9 1.0 0.0 0.6 0.2 0.6 0.6 0.4 0.6
Cardiovascular Disease 0.7 2.4 6.9 -2.3 -1.5 1.8 -2.6 -0.3 -1.1 -1.7 -2.5 -1.6 -1.4 -1.2 0.9 -1.2 -1.1 -1.0 0.1
Hypothyroidism (self reported) 1.7 4.0 6.3 -2.4 -2.1 1.9 -0.5 -1.2 -2.1 -2.0 -1.6 -2.3 -2.4 -2.1 -1.9 -2.1 -2.2 -2.5 1.6
Respiratory disease 0.4 0.9 2.3 0.8 1.2 -0.8 1.5 0.1 1.0 1.0 0.8 1.2 0.5 0.9 0.3 1.0 1.1 0.9 0.8
Type 2 Diabetes (T2D) (2018) 1.0 1.9 5.2 -1.6 -1.4 1.7 -1.8 -1.0 -1.1 -1.6 -2.3 -1.4 -1.2 -1.2 0.5 -1.1 -1.1 -1.1 0.2
Lung FEV1/FVC ratio 2.0 10.2 19.6 -3.1 -3.7 3.0 -4.4 -0.7 -3.4 -3.6 -4.3 -3.4 -3.3 -3.3 -1.9 -3.4 -3.4 -3.1 0.2
Lung FVC 1.0 4.9 11.5 -1.9 -2.1 0.5 -3.3 1.8 -1.9 -2.5 -3.0 -2.1 -2.0 -1.6 -3.4 -1.9 -1.9 -1.7 -2.4
Neuroticism 6.5 15.7 25.3 2.7 4.5 -3.6 4.7 1.9 4.2 4.7 5.0 4.6 4.7 4.1 2.4 4.2 4.2 4.1 0.9
Chronotype (morning person) 0.7 1.5 11.8 0.7 0.6 0.7 -2.1 -0.8 0.9 0.3 -0.7 0.5 -0.6 0.8 3.4 0.9 1.0 0.8 -1.2
Hair Pigment 0.0 0.3 3.0 -1.7 0.1 -0.0 -0.2 -0.3 0.2 -0.1 -0.7 0.1 0.1 -0.1 0.4 0.2 0.1 0.2 1.3
Tanning 1.2 14.8 20.2 -3.3 -4.3 4.1 -4.3 -3.0 -4.1 -4.3 -4.0 -4.5 -4.3 -4.1 -1.5 -4.1 -4.1 -4.2 1.6
Hand grip strength (left) 0.6 1.5 8.4 1.2 0.9 -0.6 2.9 -0.8 0.6 1.3 2.2 0.7 0.8 0.6 0.3 0.7 0.6 0.3 1.8
Number of treatments/medications taken 0.5 1.0 5.5 -0.5 -0.1 0.8 -2.3 0.1 0.3 -0.5 -1.2 -0.3 -0.8 0.3 2.3 0.2 0.3 0.2 -0.9
Average weekly spirits intake 2.6 3.2 5.3 -2.2 -1.9 2.3 -1.7 -1.0 -1.9 -1.9 -1.7 -2.1 -1.4 -1.9 0.3 -1.9 -1.9 -1.9 1.7
Sensitivity / hurt feelings 0.5 0.9 3.1 0.0 0.8 -0.3 1.6 -0.1 0.7 0.9 1.7 1.1 1.8 0.6 1.1 0.7 0.7 0.9 -0.0
Frequency of depressed mood in last 2 weeks 4.9 6.9 11.3 2.1 2.8 -2.8 2.5 1.9 2.7 3.2 3.4 2.7 2.9 2.8 1.9 2.8 2.7 3.0 -1.3
Hearing difficulty/problems: Yes 0.8 1.2 6.7 1.2 0.8 -1.6 -0.1 1.1 0.9 0.7 0.5 0.4 0.5 1.1 -0.2 0.8 0.9 1.1 -2.6
Relative age of first facial hair 0.4 0.8 2.2 -0.5 -1.1 0.3 0.0 -0.4 -1.2 -1.1 -0.5 -1.0 0.0 -1.2 -1.5 -1.2 -1.2 -1.0 0.4
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.9 1.0 0.8 -1.0 0.3 0.8 0.8 0.8 0.4 0.9 0.7 0.9 0.2 0.8 0.8 1.0 -1.7
Ever used hormone-replacement therapy (HRT) 2.0 2.5 10.5 0.9 1.2 -0.3 -1.1 1.8 1.6 1.1 0.5 1.5 1.6 1.5 3.2 1.5 1.5 1.7 -2.2
Ever had hysterectomy (womb removed) 0.8 0.9 4.5 -0.2 0.2 0.5 -1.5 1.2 0.3 0.2 -0.5 0.5 0.1 0.3 2.1 0.3 0.3 0.5 -2.1
Systolic blood pressure, automated reading 3.8 11.1 20.3 -4.1 -3.5 3.3 -3.6 -2.2 -3.4 -3.6 -4.5 -3.3 -3.7 -3.4 -2.1 -3.3 -3.4 -3.3 0.4
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 1.5 0.3 -0.1 0.0 -0.6 0.4 -0.0 -0.2 -0.1 -0.2 -0.1 0.1 0.2 -0.1 -0.0 0.1 -1.2
Angina 0.2 0.2 1.0 0.5 -0.4 0.3 -0.5 0.1 -0.3 -0.5 -0.8 -0.8 -1.0 -0.2 -0.2 -0.3 -0.3 -0.3 -0.5
Medication for hormone replacement therapy 0.7 0.7 3.0 0.2 0.5 -0.2 -0.8 1.5 0.7 0.5 0.1 0.8 0.4 0.7 1.4 0.7 0.6 0.8 -1.7
Vitamin and mineral supplements 0.5 0.7 2.0 0.8 0.9 -0.8 1.4 -0.1 0.7 0.8 1.2 1.1 0.8 0.7 -0.2 0.7 0.8 0.7 -0.2
Supplements: Zinc 0.5 0.5 2.0 1.0 0.7 -1.0 -0.3 -0.0 0.8 0.4 -0.1 0.5 -0.1 0.9 0.5 0.8 0.8 0.8 -1.4
Medication: Co-codamol 1.2 1.4 10.8 -0.6 0.7 -0.9 -0.1 3.3 0.8 0.6 0.0 0.5 0.4 1.0 0.3 0.9 0.8 1.2 -2.2
Medication: Metformin 0.5 0.6 1.9 0.1 -0.8 0.8 -1.2 -1.1 -0.7 -0.9 -1.4 -0.8 -0.3 -0.7 0.0 -0.7 -0.7 -0.5 0.9
Diabetes (father) 0.3 0.3 2.3 -0.4 0.2 0.1 -0.5 1.5 0.3 0.1 -0.6 0.3 0.1 0.3 1.1 0.3 0.3 0.4 -0.6
Diabetes (mother) 0.3 0.4 1.2 -0.2 0.3 -0.1 1.1 0.8 0.3 0.4 1.1 0.4 1.0 0.3 0.8 0.3 0.2 0.4 -0.5
Severe depression (siblings) 1.7 1.9 4.7 1.0 1.3 -1.0 0.9 2.2 1.3 1.4 1.5 1.2 1.5 1.3 1.3 1.3 1.3 1.6 -1.6
Pack years adult smoking proportion 3.1 4.7 7.1 2.3 2.5 -2.4 1.1 1.6 2.6 2.2 1.7 2.4 2.0 2.7 0.7 2.5 2.6 2.5 -1.8
Impedance of leg (right) 3.9 18.7 32.7 3.4 4.3 -4.1 5.4 5.3 3.9 4.4 5.4 4.9 5.7 4.1 0.1 4.0 3.9 4.2 -3.0
Leg fat-free mass (left) 0.3 1.6 8.8 0.3 -0.5 0.9 -1.0 -3.0 -0.4 -0.3 -0.8 -1.1 -1.7 -0.6 1.6 -0.4 -0.5 -0.7 2.5
Trunk fat percentage 0.2 0.7 3.5 0.3 0.9 0.2 0.7 -0.1 0.9 1.0 0.7 0.9 -0.0 0.7 1.9 0.9 0.8 0.5 1.0
Hand grip strength (right) 0.9 2.3 14.0 0.3 -0.5 0.9 2.7 -2.6 -0.9 -0.1 1.5 -0.5 -0.5 -1.0 -0.7 -0.9 -0.9 -1.3 3.7
Townsend deprivation index at recruitment 0.1 0.2 0.7 -0.6 0.0 -0.2 -0.7 0.7 0.1 -0.2 -0.4 -0.2 -0.1 0.2 -0.0 0.1 0.1 0.2 -0.8
Current tobacco smoking 0.8 1.3 3.1 -1.4 -1.2 1.2 -1.8 1.0 -1.1 -1.2 -1.1 -1.1 -0.8 -0.9 -0.4 -1.1 -1.1 -0.9 -1.4
Average weekly fortified wine intake 0.4 0.4 2.3 -0.1 0.1 -0.1 1.4 -1.2 -0.1 0.2 0.8 0.2 0.5 -0.1 -0.3 -0.1 -0.1 -0.2 1.5
Maternal smoking around birth 1.0 1.4 2.7 1.3 1.3 -1.4 0.6 1.6 1.2 1.0 0.6 1.4 0.5 1.4 -0.3 1.2 1.3 1.3 -1.6
Fed-up feelings 0.9 1.7 2.8 0.7 1.4 -0.8 0.8 1.2 1.4 1.7 1.6 1.0 1.5 1.4 1.6 1.5 1.4 1.6 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.3 4.8 1.8 1.5 -1.8 1.5 1.2 1.3 1.8 2.2 1.3 1.5 1.5 0.8 1.4 1.3 1.7 -1.3
Relative age voice broke 3.6 5.6 8.6 -1.8 -2.9 2.6 -2.2 -1.0 -2.8 -2.9 -2.7 -2.8 -1.7 -2.8 -1.2 -2.8 -2.8 -2.4 -0.2
Taking other prescription medications 1.1 1.7 3.8 1.6 1.2 -0.9 0.1 1.3 1.4 0.8 0.8 0.9 1.3 1.6 1.6 1.3 1.4 1.6 -2.0
Age when periods started (menarche) 7.4 17.7 23.1 -4.5 -4.6 3.0 -3.2 -2.0 -4.5 -4.8 -4.4 -4.8 -4.2 -4.5 -4.8 -4.5 -4.5 -4.7 3.4
Bilateral oophorectomy (both ovaries removed) 1.8 2.1 10.3 0.2 1.0 0.4 -1.2 2.1 1.2 1.0 -0.0 1.3 1.7 1.1 3.2 1.2 1.2 1.5 -1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 6.5 1.1 -0.6 0.8 -2.5 0.0 -0.3 -0.7 -1.5 -0.9 -0.8 -0.3 0.7 -0.3 -0.2 -0.3 -1.2
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 1.7 0.7 1.0 -1.1 0.4 0.0 0.9 1.0 1.3 1.0 0.9 0.9 -0.2 0.9 0.9 0.9 -0.1
Qualifications: CSEs or equivalent 0.4 0.6 2.5 0.9 0.5 -0.1 1.5 -0.7 0.2 0.7 1.3 0.5 0.3 0.2 -0.1 0.2 0.2 -0.0 1.6
Serious illness, injury or assault to yourself 3.9 4.7 7.0 1.8 2.3 -2.1 0.6 2.0 2.4 2.3 1.3 2.2 2.0 2.5 2.1 2.5 2.4 2.6 -2.6
High blood pressure 1.9 5.2 9.0 -3.0 -2.4 2.2 -2.2 -1.7 -2.2 -2.5 -3.0 -2.4 -2.5 -2.3 -1.1 -2.3 -2.2 -2.3 1.5
Hayfever, allergic rhinitis or eczema 1.2 2.5 4.3 2.0 1.8 -1.9 1.7 0.1 1.7 1.7 1.8 2.1 1.1 1.7 1.0 1.7 1.7 1.5 0.0
Multivitamins +/- minerals 1.6 2.1 4.0 -1.5 -1.5 1.4 -2.0 0.7 -1.4 -1.5 -2.0 -1.8 -1.7 -1.4 -0.6 -1.4 -1.4 -1.3 -0.3
Stomach or abdominal pain in last month 5.2 6.4 8.8 1.8 2.8 -2.5 1.9 2.0 2.8 2.8 2.7 3.0 2.8 2.8 2.1 2.8 2.8 2.8 -1.9
Supplements: Glucosamine 0.2 0.2 1.1 0.4 -0.1 0.1 -1.1 0.3 0.1 -0.2 -0.7 -0.3 -0.4 0.0 0.6 0.1 0.1 -0.0 -0.9
Diverticular disease/diverticulitis (self-reported) 1.3 1.5 9.4 1.2 1.0 -1.1 -0.1 1.8 1.0 0.9 0.5 0.9 0.5 1.1 -0.1 1.0 1.0 1.2 -3.1
Medication: Atenolol 0.6 0.8 3.2 -1.8 -0.8 0.9 -1.4 0.6 -0.5 -1.0 -1.5 -0.8 -0.7 -0.6 -0.5 -0.6 -0.6 -0.5 -0.0
Medication: Levothyroxine sodium 2.8 4.8 7.0 -1.6 -2.4 1.9 -0.9 -1.7 -2.5 -2.3 -2.0 -2.6 -2.6 -2.4 -2.6 -2.4 -2.5 -2.6 1.2
Sitting height 1.6 11.3 29.4 2.9 3.7 -3.2 5.4 -0.2 3.0 4.1 5.1 3.4 3.6 2.9 0.9 3.0 3.0 2.8 2.7
Chronic bronchitis/emphysema (father) 0.7 0.8 4.2 -1.7 -0.7 0.2 0.8 0.7 -0.8 -0.6 -0.1 -0.3 -0.0 -0.9 -2.1 -0.8 -0.8 -0.7 0.3
High blood pressure (mother) 2.1 2.9 7.1 1.0 1.7 -1.0 0.7 0.7 1.9 1.9 1.8 1.5 2.1 1.8 2.7 1.9 1.9 2.1 -0.9
Body mass index (BMI) 2.5 10.8 25.4 -2.6 -3.1 3.9 -5.0 -3.0 -2.7 -3.2 -4.6 -3.5 -4.6 -2.8 1.6 -2.7 -2.7 -3.0 1.1
Impedance of leg (left) 4.4 21.5 36.4 3.7 4.6 -4.5 5.8 5.5 4.2 4.8 5.8 5.2 6.0 4.4 0.2 4.3 4.2 4.6 -3.2
Leg predicted mass (left) 0.3 1.6 8.8 0.3 -0.5 0.8 -1.0 -3.0 -0.4 -0.3 -0.8 -1.1 -1.6 -0.6 1.7 -0.4 -0.4 -0.6 2.6
Trunk fat mass 0.2 0.7 4.4 0.4 0.6 0.3 0.4 -0.8 0.7 0.8 0.4 0.5 -0.5 0.4 2.1 0.7 0.6 0.3 1.5
Waist circumference 0.9 3.2 11.5 1.5 1.9 -1.1 -0.4 1.7 2.1 1.8 0.6 1.9 0.1 2.0 3.4 2.1 2.0 1.9 -1.6
Number of incorrect matches in round 1.9 3.1 7.3 0.9 1.9 -1.2 2.7 1.2 1.7 2.0 2.3 1.9 2.2 1.6 0.4 1.7 1.7 1.5 2.2
Past tobacco smoking 5.3 9.8 15.4 3.9 3.6 -3.9 3.4 0.6 3.5 3.5 3.0 3.9 2.5 3.5 0.4 3.4 3.5 3.2 -0.2
Alcohol usually taken with meals 1.3 2.1 4.5 2.1 1.4 -1.0 1.4 0.2 1.4 1.5 1.8 1.2 2.1 1.3 1.6 1.3 1.4 1.5 -1.0
Nervous feelings 9.0 16.8 28.0 3.0 4.5 -4.3 5.1 2.4 4.2 4.6 5.3 4.9 4.9 4.3 1.6 4.2 4.2 4.3 -0.3
Frequency of tenseness / restlessness in last 2 weeks 6.3 9.9 16.0 3.2 3.5 -3.0 3.0 1.1 3.4 3.7 4.0 3.3 3.7 3.4 1.9 3.4 3.4 3.5 -0.4
Hearing difficulty/problems with background noise 2.3 3.7 5.9 2.4 2.0 -2.3 1.3 1.4 1.9 2.0 2.2 1.9 1.8 2.1 0.8 1.9 1.9 2.0 -1.7
Hair/balding pattern: Pattern 2 0.3 0.4 1.3 -0.8 -0.4 1.0 -0.2 -0.9 -0.3 -0.5 -0.3 -0.9 -0.2 -0.4 1.1 -0.3 -0.2 -0.4 1.1
Had menopause 0.4 0.5 1.2 -0.7 -0.8 0.4 -1.1 0.2 -0.7 -1.0 -1.1 -0.8 -0.0 -0.7 -1.0 -0.7 -0.7 -0.6 -0.3
Had other major operations 0.6 0.7 3.7 -0.6 0.4 0.1 -0.6 1.3 0.5 0.5 0.2 0.5 1.4 0.5 1.9 0.6 0.5 0.7 -0.8
Forced vital capacity (FVC) 1.2 4.6 8.5 2.5 2.4 -2.9 2.6 0.8 2.2 2.4 2.9 2.2 2.0 2.3 -0.3 2.2 2.2 2.0 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 5.9 0.8 -0.7 1.0 -2.4 0.5 -0.4 -0.9 -1.7 -0.8 -1.4 -0.4 0.7 -0.4 -0.3 -0.5 -1.5
Ever unenthusiastic/disinterested for a whole week 2.2 2.7 6.4 0.8 1.7 -1.6 -0.3 2.5 1.8 1.5 0.7 1.5 1.4 1.9 1.8 1.9 1.8 2.1 -1.5
Qualifications: None of the above 0.2 0.5 4.6 -2.1 -0.1 0.2 -0.5 0.2 -0.0 -0.4 -0.8 -0.4 0.3 -0.1 -0.6 -0.1 -0.1 -0.0 1.2
Financial difficulties in last 2 years 1.4 1.9 4.6 1.5 1.3 -1.3 -0.0 2.0 1.4 1.0 0.8 0.9 0.9 1.5 1.5 1.4 1.4 1.5 -2.1
Mouth/teeth dental problems 0.2 0.3 1.1 -0.0 -0.4 0.6 -1.0 -0.8 -0.2 -0.6 -0.9 -0.4 -1.1 -0.3 0.7 -0.3 -0.2 -0.4 0.4
Heart attack 2.0 2.6 5.2 -1.4 -1.7 2.2 -1.5 -1.1 -1.6 -1.9 -1.8 -1.6 -2.3 -1.6 -0.8 -1.7 -1.6 -1.6 -0.2
Allergy 1.8 4.2 6.7 -2.6 -2.3 2.0 -2.5 -0.3 -2.1 -2.2 -2.5 -2.5 -1.7 -2.1 -1.2 -2.1 -2.1 -1.9 -0.9
Pain all over the body in last month 1.6 1.7 2.9 1.1 1.5 -1.1 0.9 1.3 1.4 1.4 1.6 1.6 1.7 1.5 0.8 1.4 1.4 1.4 -0.1
Diabetes (self-reported) 1.9 2.9 5.7 -1.4 -1.9 1.8 -2.3 -0.9 -1.8 -2.1 -2.4 -1.9 -1.8 -1.7 -1.0 -1.8 -1.7 -1.7 0.0
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 2.4 1.4 1.2 -1.3 1.4 0.1 1.2 1.0 1.6 1.4 1.1 1.2 0.3 1.2 1.1 0.9 0.4
Medication: Ramipril 1.2 1.5 2.2 -1.2 -1.4 1.2 -0.7 -1.2 -1.4 -1.3 -1.0 -1.5 -1.3 -1.4 -0.9 -1.4 -1.4 -1.4 -0.3
Medication: Simvastatin 0.4 0.6 3.0 -1.0 -0.3 0.9 -0.6 -1.7 -0.2 -0.4 -0.7 -0.1 -0.9 -0.4 0.7 -0.2 -0.2 -0.3 1.7
Fluid intelligence score 3.4 7.1 11.8 -2.4 -3.1 2.6 -3.4 -0.6 -2.9 -3.1 -3.4 -3.2 -2.6 -2.9 -0.7 -2.9 -2.9 -2.6 0.5
Illnesses of siblings 0.1 0.1 0.4 0.4 0.1 0.2 -0.6 0.3 -0.0 0.2 -0.5 0.1 -0.7 0.0 0.2 0.0 0.0 -0.1 -0.1
Neuroticism score 4.2 8.8 15.5 2.0 3.3 -2.6 3.2 1.1 3.1 3.6 3.9 3.2 3.9 3.1 2.3 3.1 3.1 3.2 0.4
Weight 0.3 1.5 5.6 0.2 -0.5 1.2 -1.2 -2.4 -0.4 -0.4 -0.9 -1.0 -1.8 -0.6 2.0 -0.4 -0.5 -0.7 2.0
Impedance of arm (right) 5.2 24.3 57.3 3.9 5.1 -5.0 7.6 4.6 4.5 5.1 7.0 5.8 5.9 4.5 -0.2 4.5 4.5 4.4 -1.1
Arm fat percentage (right) 0.5 2.0 5.3 -1.4 -1.0 2.0 -1.9 -1.2 -0.8 -1.1 -1.8 -1.1 -2.3 -1.0 2.0 -0.8 -0.8 -1.2 1.0
Trunk fat-free mass 0.2 0.9 6.3 0.8 -0.3 0.1 -0.6 -2.5 -0.3 -0.1 -0.3 -1.1 -1.1 -0.3 0.9 -0.3 -0.3 -0.4 2.0
Hip circumference 1.5 6.5 13.7 -1.6 -2.5 2.8 -2.7 -2.9 -2.3 -2.4 -2.8 -2.8 -3.7 -2.5 0.3 -2.3 -2.4 -2.7 2.5
Time employed in main current job 0.6 0.7 4.0 -2.0 -0.5 0.9 -0.8 -0.1 -0.4 -0.5 -0.6 -0.1 -1.0 -0.4 1.3 -0.3 -0.4 -0.3 -1.1
Alcohol intake versus 10 years previously 3.0 4.5 6.2 -2.0 -2.3 1.7 -2.1 -0.9 -2.3 -2.5 -2.4 -2.3 -2.2 -2.2 -2.2 -2.3 -2.3 -2.4 0.9
Father’s age at death 0.2 0.3 1.1 0.4 0.4 -0.9 1.0 -0.5 0.3 0.4 0.6 0.5 0.1 0.2 -0.8 0.2 0.3 0.1 0.3
Worrier / anxious feelings 9.3 17.5 23.7 3.5 4.6 -4.3 4.3 3.2 4.5 4.7 4.9 4.7 4.6 4.6 1.9 4.5 4.5 4.7 -1.6
Frequency of tiredness / lethargy in last 2 weeks 4.5 7.3 12.8 2.0 2.9 -2.4 1.4 2.6 2.9 3.0 3.0 2.4 3.6 2.9 2.6 2.9 2.9 3.2 -1.7
Falls in the last year 0.4 0.5 2.2 1.2 0.4 -0.3 -0.8 -0.1 0.4 0.4 0.1 0.6 0.5 0.5 1.1 0.5 0.4 0.7 -1.5
Hair/balding pattern: Pattern 3 0.4 0.7 1.3 -0.1 -1.0 1.1 -1.1 -0.3 -0.9 -0.9 -0.7 -0.8 -0.7 -0.8 -0.1 -0.9 -0.9 -0.9 -0.9
Number of live births 0.2 0.3 2.2 -0.8 0.1 -0.2 -0.1 1.5 0.2 -0.2 -0.1 -0.0 0.0 0.3 -0.0 0.2 0.2 0.3 -1.1
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.2 1.5 0.9 -1.5 1.0 0.5 0.9 1.1 1.4 1.0 0.7 0.9 -0.6 0.9 0.8 0.8 -0.3
Pulse rate 7.1 12.0 19.5 4.4 3.9 -3.5 2.9 2.0 3.8 3.9 3.7 4.0 2.9 3.8 2.2 3.8 3.8 3.7 -1.8
Happiness 3.7 4.5 10.2 2.6 2.1 -1.9 3.0 -0.7 1.9 2.4 3.2 1.8 2.5 1.8 0.8 1.9 1.9 1.8 2.0
Noisy workplace 2.1 2.6 4.2 -2.0 -1.8 1.6 -0.9 -0.6 -1.9 -1.7 -1.2 -1.6 -1.3 -1.8 -1.8 -1.9 -1.9 -1.9 0.9
Qualifications: A levels/AS levels or equivalent 0.3 0.6 2.2 -0.3 -0.7 0.2 -1.1 -0.9 -0.6 -1.0 -1.2 -0.6 -1.5 -0.7 -0.4 -0.7 -0.6 -0.7 0.1
Serious illness, injury or assault of a close relative in last 2 years 2.9 3.3 5.2 0.8 1.9 -2.1 0.9 1.9 2.0 1.9 1.7 1.8 2.3 2.0 1.3 2.0 2.0 2.3 -1.4
Mouth/teeth dental problems: Dentures 0.3 0.5 1.1 -0.5 -0.7 0.8 -0.2 -0.9 -0.8 -0.7 -0.6 -1.1 -0.4 -0.7 -0.7 -0.8 -0.8 -0.7 0.0
Asthma 0.3 0.6 1.7 0.5 0.9 -0.4 0.5 1.3 0.9 0.6 0.4 0.9 0.1 0.9 1.2 0.9 1.0 0.9 -0.3
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 4.5 -0.3 0.2 0.7 -0.4 -0.5 0.3 0.4 0.7 0.1 0.4 0.2 2.1 0.3 0.3 0.3 1.0
Medication: Cholesterol lowering 2.1 3.3 5.1 -2.1 -1.9 2.3 -2.0 -1.8 -1.7 -2.0 -1.8 -2.1 -2.0 -1.8 -0.3 -1.8 -1.7 -1.8 1.4
Depression (self-reported) 4.5 5.4 8.5 0.7 2.5 -2.4 2.4 2.1 2.5 2.6 2.9 2.1 2.6 2.6 1.6 2.6 2.5 2.7 -0.8
Medication: Lansoprazole 1.9 2.1 5.9 0.8 1.5 -1.0 0.3 1.4 1.7 1.4 1.1 1.5 0.9 1.7 2.4 1.7 1.6 1.8 -1.3
Prospective memory result 5.7 7.0 13.1 2.9 3.0 -2.6 3.3 0.7 2.8 3.2 3.6 3.0 2.5 2.8 1.1 2.8 2.7 2.6 -0.2
Lung cancer (father) 0.2 0.2 1.5 -1.2 0.3 -0.2 0.2 1.2 0.3 0.2 0.4 0.6 -0.0 0.2 -0.2 0.3 0.3 0.1 0.3
Illnesses of mother 2.0 2.5 3.9 -0.4 -1.8 1.4 -1.4 -0.5 -1.8 -1.9 -1.7 -1.8 -2.0 -1.7 -1.5 -1.9 -1.8 -1.8 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 4.0 2.0 1.1 -1.8 0.7 1.0 1.1 1.3 1.4 1.2 0.9 1.2 -0.2 1.2 1.1 1.2 -0.7
Pulse wave Arterial Stiffness index 0.9 1.0 3.0 -0.4 -1.0 1.1 -1.7 -0.8 -1.0 -0.9 -1.7 -0.7 -0.8 -1.0 -0.4 -1.0 -1.0 -0.8 -0.7
Impedance of arm (left) 5.1 23.8 59.1 4.3 5.0 -4.8 7.7 4.1 4.3 5.2 7.1 5.7 5.9 4.3 -0.2 4.4 4.3 4.3 -0.7
Arm fat mass (right) 0.5 2.0 5.9 -1.0 -0.9 1.8 -1.9 -1.7 -0.7 -0.9 -1.7 -1.1 -2.4 -0.9 2.0 -0.7 -0.7 -1.1 1.3
Trunk predicted mass 0.2 1.0 6.7 0.8 -0.3 0.0 -0.6 -2.6 -0.3 -0.2 -0.3 -1.1 -1.1 -0.3 0.8 -0.3 -0.3 -0.4 2.0
Standing height 2.9 28.6 63.7 6.0 5.7 -5.7 8.0 1.4 5.0 6.3 7.8 5.3 6.0 4.9 1.2 5.0 5.0 4.9 1.7
Length of working week for main job 0.1 0.1 0.7 -0.8 0.1 0.2 -0.2 -0.1 0.1 -0.0 -0.3 -0.2 -0.1 0.1 0.5 0.2 0.1 0.2 0.5
Exposure to tobacco smoke at home 0.4 0.4 2.0 0.2 -0.5 0.8 0.9 -0.4 -0.7 -0.1 0.2 -0.6 -0.1 -0.8 -0.3 -0.7 -0.6 -0.6 1.4
Breastfed as a baby 3.5 4.3 10.4 -1.6 -2.2 1.1 -0.9 -1.3 -2.3 -2.3 -1.7 -1.8 -1.8 -2.3 -3.2 -2.4 -2.3 -2.6 2.1
Tense / ‘highly strung’ 6.4 10.7 15.2 2.9 3.6 -3.5 3.6 0.7 3.5 3.8 3.9 3.8 3.6 3.5 1.9 3.5 3.5 3.6 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 3.1 4.7 9.1 1.9 2.3 -1.5 2.7 1.1 2.1 2.6 3.0 2.3 2.7 2.1 2.2 2.1 2.1 2.2 0.5
Hair/balding pattern: Pattern 4 0.6 1.5 4.2 -1.9 -1.2 1.3 -2.1 -0.0 -1.1 -1.3 -1.7 -1.2 -0.8 -1.2 -0.5 -1.1 -1.1 -1.0 0.8
Birth weight of first child 0.1 0.3 2.4 0.1 0.2 -0.3 1.5 -0.5 0.0 0.4 0.9 0.3 0.4 -0.1 0.1 0.1 0.0 0.0 0.4
Peak expiratory flow (PEF) 0.1 0.2 1.0 0.8 0.1 -0.3 0.6 -1.0 -0.0 0.3 0.3 0.2 -0.1 -0.1 -0.7 0.0 -0.0 -0.1 0.8
Pulse wave reflection index 1.4 1.7 5.4 -0.9 -1.2 1.4 -2.3 -1.4 -1.1 -1.2 -2.3 -1.2 -0.5 -1.1 0.5 -1.1 -1.1 -0.8 0.8
Ever highly irritable/argumentative for 2 days 2.5 3.0 8.9 -1.9 -1.8 1.8 -3.0 -0.1 -1.7 -1.8 -2.4 -2.0 -1.4 -1.6 0.0 -1.7 -1.7 -1.3 -1.1
Loud music exposure frequency 0.3 0.3 1.7 0.4 -0.4 0.1 1.0 -0.2 -0.5 -0.3 0.4 -0.2 0.1 -0.4 -1.3 -0.5 -0.6 -0.3 0.6
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.7 1.3 0.3 -0.4 1.0 -1.2 0.2 0.5 0.8 0.6 -0.5 0.2 0.3 0.2 0.2 -0.0 1.1
Mouth/teeth dental problems: Bleeding gums 2.0 2.6 6.8 1.5 1.2 -1.4 2.6 1.9 1.0 1.6 2.6 1.5 2.6 1.1 -0.1 1.0 0.9 1.4 -0.9
Blood clot in the leg (DVT) 1.5 1.9 3.6 1.5 1.4 -1.1 1.7 0.6 1.4 1.4 1.9 1.5 1.9 1.4 1.0 1.3 1.4 1.2 -0.4
Medication: Paracetamol 5.5 9.1 12.4 1.7 3.3 -2.9 2.0 3.2 3.4 3.3 2.7 3.4 3.2 3.4 2.7 3.4 3.4 3.5 -2.0
Headache pain in last month 6.7 11.6 17.8 2.2 3.8 -2.7 3.9 2.5 3.6 4.2 4.2 3.8 3.8 3.5 2.8 3.7 3.6 3.6 -0.3
Medication for cholesterol, blood pressure or diabetes 2.1 3.5 6.7 2.6 1.8 -2.0 2.0 1.8 1.7 2.1 2.0 2.1 2.5 1.7 0.3 1.7 1.6 1.8 -1.0
Glaucoma (self-reported) 4.3 5.1 6.8 1.1 2.5 -2.4 1.8 2.5 2.6 2.2 2.0 2.5 2.5 2.6 1.1 2.5 2.6 2.6 -1.8
Gout (self-reported) 3.5 4.8 6.9 2.2 2.5 -2.6 1.7 1.1 2.5 2.5 2.3 2.2 2.3 2.5 0.8 2.5 2.6 2.5 -0.4
Hypothyroidism/myxoedema (self-reported) 1.5 3.0 4.6 -1.6 -1.8 1.5 -0.5 -1.4 -1.8 -1.8 -1.5 -2.0 -2.1 -1.8 -1.8 -1.8 -1.8 -2.1 1.6
Medication: Amlodipine 1.0 1.4 4.9 -2.2 -1.1 0.8 -2.1 0.2 -0.8 -1.2 -1.8 -1.1 -0.9 -0.7 -0.6 -0.8 -0.9 -0.6 -0.9
Medication: Ventolin 100micrograms inhaler 0.4 0.6 3.3 0.9 0.7 0.0 0.1 0.5 0.8 0.5 -0.0 0.7 -0.2 0.7 1.8 0.8 0.8 0.7 -0.7
Birth weight 0.4 0.9 2.8 0.8 1.0 -1.2 1.3 0.8 0.7 1.2 1.7 0.8 0.8 0.7 -0.1 0.7 0.7 0.7 0.6
Chronic bronchitis/emphysema (mother) 0.9 1.1 3.1 -0.3 0.9 -1.5 1.8 1.3 0.8 1.1 1.3 1.0 0.9 0.9 -0.8 0.9 0.8 0.9 0.1
High blood pressure (siblings) 0.1 0.2 0.8 -0.9 -0.1 -0.3 -0.1 0.8 0.0 -0.2 0.1 -0.1 0.6 0.1 -0.0 0.0 0.0 0.2 -0.7
Forced vital capacity (FVC), Best measure 1.5 5.4 10.2 3.0 2.5 -3.2 2.3 1.2 2.4 2.6 2.8 2.4 2.1 2.4 0.0 2.4 2.4 2.3 -0.5
Body fat percentage 0.1 0.5 4.1 -0.5 -0.1 1.2 -0.7 -0.5 0.0 0.0 -0.6 -0.1 -1.0 -0.2 2.0 0.1 0.0 -0.3 0.7
Leg fat percentage (right) 0.9 3.3 8.6 -1.8 -1.6 2.6 -2.9 -0.8 -1.2 -1.6 -2.7 -1.6 -2.5 -1.4 1.9 -1.2 -1.2 -1.4 0.2
Arm fat-free mass (right) 0.3 1.4 8.9 0.6 -0.5 0.6 -1.1 -3.0 -0.4 -0.2 -0.8 -1.2 -1.4 -0.5 1.4 -0.3 -0.4 -0.5 2.0
Exposure to tobacco smoke outside home 0.2 0.2 1.2 -1.1 0.4 0.0 0.5 0.7 0.4 0.4 0.3 0.4 0.4 0.3 0.4 0.4 0.4 0.4 0.7
Comparative body size at age 10 1.6 4.4 7.9 -1.5 -2.5 2.8 -2.4 0.0 -2.3 -2.2 -2.2 -2.7 -2.4 -2.2 1.1 -2.2 -2.3 -1.9 -1.2
Number of full brothers 0.9 1.1 2.7 -1.7 -1.1 1.6 -1.6 0.3 -1.0 -1.2 -1.0 -1.1 -0.7 -1.0 0.5 -1.0 -1.0 -0.8 -0.1
Worry too long after embarrassment 2.7 4.6 8.6 2.4 2.1 -1.7 0.7 1.0 2.1 2.2 2.2 2.2 2.9 2.1 2.5 2.1 2.1 2.5 -2.4
Seen a psychiatrist for nerves, anxiety, tension or depression 4.7 6.1 8.8 2.0 2.7 -2.0 2.0 2.3 2.6 3.0 3.0 2.7 2.6 2.6 2.3 2.6 2.6 2.7 -1.4
Wheeze or whistling in the chest in last year 3.9 6.9 9.6 2.6 3.1 -2.4 2.1 1.3 3.0 3.0 3.0 3.0 2.9 2.9 2.2 2.9 3.0 2.9 -0.5
Number of children fathered 0.8 0.8 2.6 -1.4 -0.8 1.6 -1.5 0.2 -0.7 -0.8 -0.8 -0.9 -0.4 -0.7 1.2 -0.8 -0.7 -0.7 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 5.7 0.5 1.2 -1.1 2.4 -0.3 1.1 1.4 1.8 1.8 1.3 1.0 0.7 1.1 1.1 1.1 0.7
Age at first live birth 0.9 1.5 3.9 -0.5 -1.3 0.6 0.1 -1.7 -1.4 -1.0 -0.8 -1.4 -1.4 -1.4 -2.0 -1.3 -1.4 -1.4 0.7
Pulse wave peak to peak time 1.5 1.8 5.1 0.8 1.4 -1.4 2.3 0.8 1.3 1.3 2.2 1.1 1.1 1.3 0.5 1.3 1.3 1.1 0.9
Health satisfaction 0.9 1.2 2.7 1.6 1.1 -1.1 -0.1 -0.2 1.3 1.0 0.6 0.9 0.5 1.4 1.3 1.3 1.3 1.4 -0.8
Shortness of breath walking on level ground 0.4 0.4 0.9 1.0 0.8 -0.2 -0.1 -0.1 0.8 0.8 0.5 0.3 0.6 0.7 0.6 0.8 0.8 0.6 0.9
Qualifications: College or University degree 2.4 7.7 14.7 3.8 2.9 -3.4 2.4 1.4 2.9 3.0 2.6 2.9 2.9 2.9 1.9 2.9 2.9 3.0 -1.4
Eye problems/disorders: None of the above 3.1 3.6 5.0 -1.5 -2.2 1.7 -2.1 -0.3 -2.2 -2.1 -1.8 -2.0 -2.2 -2.1 -1.7 -2.2 -2.2 -2.2 0.1
Mouth/teeth dental problems: Loose teeth 1.6 1.9 3.3 1.2 1.6 -1.8 1.6 0.1 1.6 1.3 1.2 1.5 1.5 1.5 0.2 1.6 1.6 1.5 0.4
Emphysema/chronic bronchitis 0.5 0.5 5.3 0.7 -0.0 -0.8 1.1 -0.5 -0.2 -0.1 0.5 -0.1 0.2 -0.1 -2.3 -0.2 -0.2 -0.1 0.6
Medication for pain relief, constipation, heartburn 3.9 6.6 12.3 -2.2 -2.7 1.8 -1.0 -1.6 -2.9 -2.8 -2.3 -2.5 -3.2 -2.9 -3.5 -2.9 -2.9 -3.1 1.0
Neck or shoulder pain in last month 1.4 2.0 7.0 -0.4 1.4 -1.4 0.2 2.7 1.5 1.4 0.5 1.2 1.5 1.6 0.7 1.5 1.5 1.7 -1.4
Medication: Blood pressure 2.3 4.1 9.4 -3.1 -2.1 1.8 -1.9 -1.3 -1.9 -2.2 -2.2 -2.3 -2.6 -2.0 -1.1 -2.0 -1.9 -1.9 1.2
Angina (self-reported) 0.2 0.3 1.1 0.6 -0.5 0.5 -0.7 0.1 -0.4 -0.5 -0.8 -0.8 -1.1 -0.3 -0.1 -0.4 -0.4 -0.3 -0.6
Migraine (self-reported) 1.3 1.6 8.2 1.6 1.2 -1.6 2.9 -0.2 0.9 1.3 1.5 1.1 0.8 0.9 -0.9 0.9 0.9 0.6 1.3
Medication: Ibuprofen 0.6 0.7 3.0 -1.2 -0.5 1.3 -1.4 -0.8 -0.4 -0.5 -0.4 -0.6 -0.4 -0.5 1.7 -0.4 -0.4 -0.4 1.1
Medication: Allopurinol 1.6 2.2 3.6 1.9 1.7 -1.6 1.1 0.5 1.7 1.5 1.5 1.4 1.8 1.7 0.6 1.6 1.7 1.6 -0.6
Medication: Omeprazole 2.8 3.3 6.6 1.4 1.7 -1.6 -0.5 2.0 2.0 1.4 0.7 1.6 1.7 2.1 2.5 2.0 2.0 2.2 -2.6
Medication: Seretide 50 evohaler 0.1 0.1 0.4 -0.7 0.2 -0.2 -0.5 0.4 0.2 0.0 -0.4 0.1 -0.6 0.2 0.2 0.1 0.2 -0.0 0.1
Mean time to correctly identify matches 0.5 0.9 5.1 -2.2 -0.6 0.3 -0.2 1.2 -0.6 -0.8 -0.9 -0.5 0.0 -0.8 -1.9 -0.7 -0.6 -0.6 0.9
Heart disease (mother) 0.3 0.3 1.8 0.1 0.3 0.2 -0.9 0.4 0.5 0.2 -0.5 0.4 0.8 0.4 1.3 0.5 0.5 0.7 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.5 2.2 -1.5 -1.3 1.3 -1.4 -0.9 -1.3 -1.5 -1.4 -1.2 -0.6 -1.3 -0.9 -1.3 -1.3 -1.2 0.6
Whole body fat mass 0.2 0.7 4.5 -0.3 -0.1 1.0 -0.9 -1.0 0.0 0.0 -0.6 -0.3 -1.3 -0.1 2.1 0.1 0.0 -0.3 1.1
Leg fat mass (right) 0.6 2.3 6.2 -1.2 -1.0 2.0 -2.5 -1.4 -0.7 -1.0 -2.1 -1.3 -2.2 -0.9 2.3 -0.7 -0.7 -1.0 1.0
Arm predicted mass (right) 0.3 1.4 8.5 0.4 -0.6 0.6 -1.1 -2.9 -0.5 -0.4 -0.9 -1.3 -1.6 -0.6 1.1 -0.5 -0.5 -0.7 2.0
Pulse rate, automated reading 3.9 12.7 24.6 5.0 3.8 -3.8 2.0 2.2 3.9 3.6 3.0 4.4 2.0 4.0 2.4 3.9 3.9 3.7 -3.7
Alcohol intake frequency. 1.4 3.3 5.4 2.3 2.1 -2.2 1.1 1.2 2.2 2.1 1.1 2.1 1.0 2.2 0.8 2.2 2.2 2.1 -0.8
Comparative height size at age 10 4.1 22.6 37.6 5.5 5.3 -5.0 5.9 2.0 4.9 5.5 6.1 5.0 4.8 4.9 2.3 4.9 4.9 4.7 -0.3
Number of full sisters 0.5 0.6 5.0 -2.2 -0.5 0.5 -0.4 1.0 -0.6 -0.6 -0.8 -0.5 -0.4 -0.5 -0.8 -0.6 -0.5 -0.4 -0.1
Suffer from ‘nerves’ 6.9 10.8 18.3 2.6 3.6 -3.6 3.7 1.0 3.4 3.9 4.3 3.7 4.2 3.4 1.2 3.5 3.4 3.4 1.1
Overall health rating 2.0 4.3 6.4 1.3 2.3 -2.0 0.5 2.4 2.4 2.1 1.6 2.1 1.5 2.5 1.6 2.3 2.4 2.5 -2.4
Chest pain or discomfort 3.6 5.2 8.6 2.3 2.5 -2.9 2.9 1.6 2.4 2.5 2.5 2.4 2.3 2.4 0.1 2.4 2.4 2.3 0.0
Had major operations 1.3 1.5 4.5 -2.0 -1.2 0.3 -0.7 1.7 -1.2 -1.2 -1.2 -1.1 -0.2 -0.9 -2.1 -1.2 -1.2 -1.0 -0.4
Age at last live birth 0.2 0.3 2.1 -0.1 -0.4 -0.4 0.7 -0.4 -0.4 -0.4 -0.1 -0.7 -0.6 -0.4 -1.5 -0.4 -0.4 -0.5 -0.1
Family relationship satisfaction 2.5 3.1 12.9 2.6 1.5 -1.2 2.9 -1.0 1.1 1.9 3.6 1.7 1.9 1.2 0.8 1.1 1.1 1.0 0.3
Leg pain on walking 0.4 0.5 1.5 -0.4 -0.7 0.6 -1.2 0.7 -0.6 -0.5 -1.0 -0.7 -0.5 -0.4 -0.7 -0.6 -0.6 -0.4 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 1.8 -0.2 0.1 -0.0 0.5 1.4 0.1 0.1 0.2 0.3 -0.1 0.2 0.1 0.2 0.1 0.1 -0.6
Commuting to job workplace: Car/motor vehicle 0.1 0.2 2.2 -0.4 0.1 -0.0 0.3 0.1 0.1 0.1 -0.1 -0.3 -0.0 -0.0 -0.1 0.1 0.1 0.1 1.5
Illness, injury, bereavement, stress in last 2 years 5.4 6.6 8.8 -2.3 -2.8 2.4 -1.2 -1.8 -2.9 -2.8 -2.3 -2.9 -2.6 -3.0 -2.8 -3.0 -2.9 -2.9 1.8
Medication: Aspirin 0.3 0.4 1.8 1.0 0.4 0.2 -0.3 -0.5 0.6 0.4 -0.1 0.4 0.6 0.5 1.4 0.6 0.7 0.6 1.1
Supplements: Vitamin C 0.1 0.1 1.0 0.5 0.1 -0.1 -1.0 -0.1 0.2 0.1 -0.1 0.1 -0.2 0.2 0.0 0.2 0.2 0.1 -0.1
Knee pain experienced in last month 0.3 0.5 2.3 -1.0 -0.5 1.1 -1.5 1.0 -0.2 -0.4 -0.9 -0.3 0.0 -0.3 1.0 -0.2 -0.3 -0.1 -0.6
Hypertension (Self-reported) 1.8 5.1 10.1 -3.0 -2.4 2.1 -2.4 -1.5 -2.1 -2.6 -3.2 -2.3 -2.5 -2.2 -1.3 -2.2 -2.1 -2.1 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.6 -0.5 0.6 -0.8 0.5 0.5 0.6 0.3 0.4 0.7 -0.3 0.6 0.6 0.5 0.6 0.4 -0.3
Illnesses of father: Heart disease 0.6 0.9 2.3 -0.8 -1.1 0.9 -1.5 -0.2 -0.9 -1.1 -1.3 -0.9 -1.4 -0.8 -0.5 -0.9 -0.9 -0.8 -0.2
Illnesses of siblings: Diabetes 1.2 1.4 2.4 -0.7 -1.4 0.9 -0.8 -0.0 -1.4 -1.4 -1.0 -1.2 -1.2 -1.4 -1.6 -1.5 -1.4 -1.5 -0.3
Smoking status: Previous 2.4 3.6 7.2 -2.3 -2.2 2.7 -2.3 -0.5 -2.0 -2.0 -1.6 -2.5 -1.2 -2.1 0.6 -2.0 -2.1 -1.8 0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.9 4.0 14.6 2.1 2.0 -2.2 3.8 -0.2 1.6 2.3 3.0 2.0 1.6 1.6 -0.1 1.7 1.6 1.5 1.1
Whole body fat-free mass 0.2 1.1 7.8 0.8 -0.2 0.2 -0.7 -2.8 -0.2 -0.1 -0.4 -1.0 -1.3 -0.3 1.2 -0.2 -0.2 -0.4 2.1
Leg fat-free mass (right) 0.3 1.4 8.7 0.7 -0.2 0.6 -0.7 -2.9 -0.2 0.0 -0.5 -0.9 -1.5 -0.4 1.7 -0.2 -0.2 -0.4 2.4
Arm fat percentage (left) 0.5 1.8 4.9 -1.1 -0.9 1.9 -1.7 -1.5 -0.7 -1.0 -1.6 -1.0 -2.2 -0.9 2.0 -0.7 -0.7 -1.2 1.2
Average weekly red wine intake 0.6 0.8 4.5 0.4 -0.4 1.6 -0.3 -1.6 -0.4 -0.3 -0.3 -0.6 -0.1 -0.6 2.1 -0.4 -0.4 -0.4 1.4
Handedness (chirality/laterality): Left-handed 0.8 0.9 2.6 1.6 1.0 -1.2 0.4 -1.0 1.1 0.9 0.7 0.6 0.9 1.1 0.7 1.1 1.1 1.0 0.5
Mood swings 2.6 4.7 8.5 0.9 2.5 -2.2 2.6 0.7 2.3 2.6 2.9 2.0 2.5 2.2 1.4 2.3 2.3 2.2 1.6
Loneliness, isolation 0.6 0.8 2.4 0.7 0.9 -0.5 1.2 -0.2 0.7 1.2 1.3 0.6 1.5 0.7 0.7 0.8 0.8 0.9 0.8
Long-standing illness, disability or infirmity 0.8 1.2 7.0 -0.0 0.5 -0.0 -1.6 1.1 0.7 0.2 -0.4 0.5 -0.1 0.8 2.1 0.7 0.7 0.9 -2.7
Ever had bowel cancer screening 0.3 0.4 0.7 0.9 0.6 -0.8 0.1 0.1 0.7 0.4 0.8 0.8 0.6 0.6 0.4 0.6 0.7 0.7 -0.4
Diabetes diagnosed by doctor 2.1 3.4 7.7 -1.6 -2.0 1.9 -2.7 -1.0 -1.8 -2.3 -2.8 -1.9 -1.9 -1.7 -0.8 -1.8 -1.8 -1.7 0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.5 -0.7 -0.0 0.3 -0.1 0.4 0.1 -0.1 0.1 0.2 0.2 0.2 0.7 0.1 0.0 0.1 -0.6
Friendships satisfaction 1.9 2.4 9.7 1.8 1.1 -1.1 3.1 -1.8 0.7 1.4 2.9 1.1 1.4 0.7 -0.1 0.7 0.7 0.5 1.8
Qualifications: nursing, teaching 0.2 0.3 2.0 0.1 -0.2 0.4 -1.0 0.4 -0.1 -0.1 -0.0 -0.1 -0.0 -0.1 1.4 -0.1 -0.1 0.1 -0.9
Commuting to job workplace: Walk 0.7 0.7 3.0 -0.7 -0.8 0.6 -0.6 0.4 -0.8 -0.9 -0.6 -0.3 -1.1 -0.7 -1.0 -0.8 -0.8 -1.0 -1.7
Eye problems/disorders: Cataract 2.0 2.4 4.9 1.7 1.7 -1.4 2.2 0.5 1.6 1.5 1.6 1.1 2.2 1.5 0.9 1.6 1.7 1.6 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.0 0.1 0.5 -0.2 -0.1 0.0 -0.7 0.4 -0.2 -0.1 -0.4 -0.1 -0.2 -0.2 -0.1 -0.2 -0.2 -0.2 -0.1
Medication for cholesterol 0.9 1.4 8.2 -0.2 0.5 -0.7 2.4 -1.3 0.2 0.7 1.9 0.2 0.5 0.2 -1.2 0.2 0.2 -0.2 2.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.3 6.2 1.7 1.5 -1.0 1.7 0.0 1.4 1.6 2.1 1.2 2.5 1.3 1.1 1.4 1.4 1.4 1.1
Back pain experienced in last month 0.7 1.0 2.7 -1.2 -0.9 0.4 -1.6 1.1 -0.7 -1.1 -1.6 -0.8 -1.1 -0.6 -0.2 -0.7 -0.7 -0.5 -1.3
Mineral and other dietary supplements 0.6 0.8 6.0 0.5 0.4 -0.6 2.4 -0.2 0.1 0.6 1.5 0.8 0.5 0.2 -1.4 0.2 0.1 0.1 0.8
Breast cancer (self-reported) 0.1 0.2 0.4 -0.6 0.4 -0.4 -0.2 0.4 0.5 0.4 0.1 0.6 0.5 0.4 -0.0 0.5 0.5 0.5 -0.2
Asthma (self-reported) 0.5 0.9 1.6 0.8 1.2 -0.7 0.7 1.2 1.1 0.9 0.7 1.2 0.3 1.1 1.2 1.1 1.2 1.0 -0.3
Osteoporosis (self-reported) 0.5 0.6 1.3 -0.2 -0.8 0.6 -0.6 0.1 -0.9 -0.8 -0.5 -0.6 -0.6 -0.7 -1.1 -0.9 -0.9 -0.8 -1.1
Osteoarthritis (self-reported) 1.0 1.3 4.2 0.2 1.1 -0.6 -0.8 1.4 1.4 1.0 -0.3 0.8 1.1 1.3 2.0 1.4 1.4 1.4 -0.1
Medication: Aspirin 0.2 0.3 1.1 0.4 0.2 0.4 -0.4 -0.4 0.4 0.2 -0.1 0.2 0.6 0.3 1.0 0.4 0.4 0.4 1.0
Medication: Gliclazide 0.2 0.2 0.5 0.1 0.4 -0.2 -0.1 0.1 0.5 0.3 0.2 0.6 0.6 0.5 0.7 0.5 0.5 0.5 -0.1
Illnesses of father: None of the above (group 1) 1.2 1.5 3.7 1.1 1.4 -0.9 0.5 0.3 1.4 1.4 1.3 1.4 1.1 1.3 1.9 1.4 1.4 1.2 -0.4
Smoking status: Current 1.5 2.3 4.2 -1.9 -1.7 1.7 -2.0 0.7 -1.6 -1.8 -1.6 -1.6 -1.4 -1.4 -0.6 -1.6 -1.6 -1.4 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 2.0 0.2 -0.4 -0.4 -1.0 1.4 -0.2 -0.5 -0.6 -0.2 -0.5 -0.1 -1.2 -0.2 -0.2 0.0 -1.4
Whole body water mass 0.2 1.3 8.5 0.7 -0.3 0.4 -0.9 -2.9 -0.2 -0.1 -0.5 -1.1 -1.3 -0.3 1.4 -0.2 -0.3 -0.4 2.1
Leg predicted mass (right) 0.3 1.4 8.7 0.7 -0.2 0.6 -0.8 -2.9 -0.2 -0.0 -0.5 -0.9 -1.5 -0.4 1.7 -0.2 -0.2 -0.4 2.3
Arm fat mass (left) 0.5 2.2 5.7 -0.8 -0.9 1.8 -2.0 -2.1 -0.7 -0.9 -1.7 -1.1 -2.4 -0.9 2.2 -0.7 -0.7 -1.1 1.6
Number of self-reported non-cancer illnesses 0.3 0.6 1.3 0.2 0.8 -0.7 -0.1 0.3 1.1 0.3 -0.2 0.7 0.2 1.1 1.2 0.9 1.1 1.0 -0.8
Average weekly champagne plus white wine intake 5.1 7.0 9.9 -2.3 -3.1 2.9 -2.7 -1.9 -3.0 -3.1 -2.3 -3.0 -1.9 -3.1 -1.7 -3.1 -3.0 -3.0 1.0
Miserableness 0.2 0.3 1.9 -1.4 -0.1 0.4 -0.8 0.0 -0.1 -0.0 -0.3 -0.3 -0.1 -0.1 0.5 -0.0 -0.1 0.1 1.1
Guilty feelings 3.1 4.7 8.9 1.5 2.4 -2.3 2.8 1.4 2.2 2.5 3.0 2.3 2.6 2.2 0.3 2.1 2.2 2.2 0.1
Wears glasses or contact lenses 6.1 7.1 9.7 -2.3 -2.8 2.3 -2.2 -2.0 -2.7 -3.1 -2.9 -2.9 -2.8 -2.7 -2.5 -2.8 -2.7 -3.0 2.5
Ever taken oral contraceptive pill 0.4 0.4 2.5 -1.5 0.2 0.2 -0.8 0.2 0.4 0.0 0.1 0.3 0.4 0.3 1.6 0.3 0.4 0.4 -0.2
Hearing aid user 2.8 3.2 6.7 -2.0 -1.8 2.0 -2.3 -1.1 -1.6 -1.9 -2.3 -2.0 -2.6 -1.6 -0.3 -1.6 -1.6 -1.7 -0.5
Mother’s age at death 1.3 1.6 7.4 -0.7 -1.0 0.5 1.3 -0.4 -1.3 -0.8 0.0 -0.8 -1.0 -1.3 -2.7 -1.3 -1.3 -1.6 1.6
Financial situation satisfaction 0.1 0.2 0.9 -0.0 0.1 -0.2 0.5 -0.4 0.1 0.2 0.9 0.0 1.0 0.2 0.0 0.1 0.1 0.2 -0.3
Tinnitus: Yes, now most or all of the time 2.8 3.3 4.8 1.7 2.1 -2.1 2.1 1.1 2.0 2.1 1.9 2.2 1.4 2.0 0.5 2.0 2.1 1.8 0.3
Commuting to job workplace: Public transport 0.4 0.4 2.2 1.5 0.1 0.6 0.3 -0.6 0.1 0.3 0.8 0.3 0.2 -0.0 1.5 0.0 0.1 0.1 -0.8
Eye problems/disorders: Glaucoma 1.9 2.2 4.0 0.4 1.6 -2.0 1.6 1.7 1.6 1.3 1.3 1.7 1.5 1.7 -0.3 1.5 1.6 1.6 -1.1
Medication: Blood pressure 1.0 1.9 6.7 -1.4 -1.5 1.2 -2.0 0.1 -1.3 -1.7 -2.6 -1.3 -1.1 -1.3 -0.5 -1.3 -1.3 -1.0 -0.8
Pain type(s) experienced in last month: Hip pain 1.1 1.4 7.5 0.1 0.9 -0.0 -1.3 1.0 1.1 1.0 0.3 1.0 0.8 1.0 2.7 1.2 1.1 1.4 -1.3
Supplements: Fish oil (including cod liver oil) 0.4 0.5 3.8 -0.5 -0.3 0.4 -1.9 -0.2 -0.0 -0.4 -1.3 -0.7 -0.6 -0.1 1.1 -0.0 -0.0 -0.0 -0.4
High cholesterol (Self-reported) 0.5 0.8 2.7 -0.8 -0.7 0.7 -1.3 -1.5 -0.4 -0.9 -1.6 -0.7 -1.2 -0.5 0.1 -0.5 -0.4 -0.5 0.8
Medication: Bendroflumethiazide 1.5 2.3 6.8 -2.6 -1.4 1.1 -2.4 0.4 -1.2 -1.7 -2.4 -1.3 -1.6 -1.2 -0.9 -1.3 -1.2 -1.0 -0.4
Medication: Paracetamol 2.7 4.2 6.1 0.9 2.3 -1.9 1.0 2.3 2.4 2.1 1.8 2.2 2.3 2.4 2.0 2.3 2.4 2.5 -1.0
Medication: Lisinopril 1.2 1.5 3.4 -1.1 -1.3 1.8 -1.1 -1.2 -1.1 -1.2 -1.6 -1.2 -1.6 -1.2 0.3 -1.1 -1.1 -1.2 0.4
Medication: Atorvastatin 0.5 0.6 2.0 -0.6 -0.8 0.3 -0.9 0.7 -0.6 -1.0 -1.4 -1.1 -0.4 -0.5 -0.9 -0.7 -0.6 -0.4 -1.0
Illnesses of father: High blood pressure 1.5 1.9 9.5 -1.2 -1.2 0.1 -0.2 -0.6 -1.3 -1.5 -1.6 -1.4 -1.6 -1.1 -3.1 -1.3 -1.2 -1.3 0.7
Alcohol drinker status: Never 0.6 0.8 1.7 0.9 0.9 -0.2 0.8 -0.5 1.0 0.9 0.9 0.8 1.1 0.9 1.3 1.0 1.0 1.0 -0.4
Ever smoked 7.1 12.4 20.0 -4.5 -4.1 3.7 -3.6 -1.1 -3.9 -4.0 -3.4 -4.3 -3.0 -3.9 -1.7 -3.9 -4.0 -3.8 0.6
Basal metabolic rate 0.2 1.2 7.1 0.8 -0.2 0.4 -0.8 -2.7 -0.1 -0.0 -0.4 -0.9 -1.4 -0.2 1.6 -0.1 -0.2 -0.4 2.0
Leg fat percentage (left) 0.9 3.2 8.1 -1.7 -1.5 2.6 -2.8 -1.0 -1.2 -1.6 -2.7 -1.6 -2.4 -1.4 1.9 -1.2 -1.2 -1.4 0.2
Arm fat-free mass (left) 0.2 1.1 7.2 0.7 -0.2 0.3 -1.1 -2.7 -0.1 0.0 -0.7 -0.9 -1.3 -0.1 1.7 -0.0 -0.1 -0.2 1.7
Number of operations (self-reported) 0.6 1.0 5.6 -1.0 0.6 -0.5 -0.0 2.4 0.7 0.6 0.6 1.0 1.1 0.8 1.1 0.7 0.7 0.8 -1.0
Average weekly beer plus cider intake 0.5 0.8 3.6 -1.0 -0.5 0.3 0.7 0.3 -0.8 -0.5 -0.5 -0.3 -0.8 -0.8 -1.9 -0.8 -0.8 -1.0 1.5
Irritability 0.8 1.4 4.3 -1.0 -0.9 1.8 -1.1 -1.9 -0.8 -0.7 -0.5 -1.2 -0.0 -1.0 1.4 -0.8 -0.8 -0.8 2.1
Risk taking 3.0 4.3 7.6 2.0 2.2 -1.7 0.5 1.3 2.3 2.3 1.9 2.2 2.4 2.3 2.7 2.3 2.3 2.4 -1.3
Ever had prostate specific antigen (PSA) test 0.3 0.3 3.1 -0.2 0.1 0.2 -0.1 -1.1 0.1 -0.2 0.3 0.0 0.4 -0.0 0.6 0.0 0.1 -0.1 1.8
Fractured/broken bones in last 5 years 1.2 1.6 2.8 -1.4 -1.4 1.1 -1.1 -0.3 -1.5 -1.3 -1.7 -1.2 -1.1 -1.3 -1.4 -1.4 -1.5 -1.2 -0.5
Age started oral contraceptive pill 0.2 0.2 1.0 0.7 0.4 -1.0 0.5 0.5 0.5 0.4 -0.3 0.2 0.5 0.4 -0.5 0.5 0.4 0.5 0.4
Diastolic blood pressure, automated reading 0.5 1.6 3.7 0.5 1.5 -1.1 0.4 0.9 1.5 1.6 0.3 1.9 0.5 1.5 1.3 1.5 1.5 1.5 -1.3
Ever depressed for a whole week 0.6 0.8 1.9 0.4 0.8 -0.6 -0.3 1.4 0.8 0.8 0.3 0.9 1.3 0.9 1.3 0.8 0.8 1.1 -0.6
Unable to work because of sickness or disability 0.6 0.8 5.1 -0.7 0.6 -1.1 -0.2 2.2 0.6 0.4 -0.3 0.9 -0.5 0.7 -0.5 0.6 0.6 0.7 -1.5
Commuting to job workplace: Cycle 2.8 3.3 7.0 -1.5 -2.0 1.1 -1.1 -1.3 -2.0 -2.1 -1.6 -1.7 -2.2 -1.7 -2.6 -2.0 -2.0 -2.3 1.0
Myopia 2.5 3.7 6.3 -1.2 -2.3 1.9 -2.5 -1.4 -2.2 -2.2 -2.1 -2.1 -1.6 -2.2 -0.7 -2.1 -2.2 -1.9 -0.7
Vascular/heart problems diagnosed by doctor 1.5 4.1 7.6 2.8 2.1 -2.1 1.9 1.2 1.9 2.3 2.6 2.2 2.3 2.0 0.7 2.0 1.9 1.9 -0.8
Cholesterol lowering medication 0.3 0.4 1.6 1.3 0.5 -0.5 -0.4 0.3 0.7 0.4 -0.6 0.7 0.3 0.7 0.8 0.7 0.7 0.9 -0.5
Medication: Omeprazole (e.g. Zanprol) 2.6 3.2 6.1 1.5 1.7 -1.6 -0.3 1.8 1.9 1.5 0.9 1.5 1.7 2.0 2.5 1.9 1.9 2.1 -2.4
Pain experienced in last month 1.7 2.8 5.0 -0.4 -1.8 1.6 0.2 -2.2 -1.9 -1.7 -0.7 -1.4 -1.3 -2.0 -2.1 -2.0 -1.9 -2.2 1.4
Supplements: Calcium 0.5 0.6 1.2 0.6 0.8 -1.1 0.2 0.7 0.9 0.6 0.5 0.8 1.0 0.9 0.3 0.9 0.9 0.9 -0.3
Basal cell carcinoma (self-reported) 7.1 8.5 15.0 3.9 3.1 -2.9 2.3 1.6 3.1 3.2 3.0 3.3 2.9 3.1 2.4 3.1 3.1 3.1 -1.3
Heart attack/myocardial infarction (self-reported) 1.3 1.7 3.5 -1.1 -1.4 1.9 -1.3 -0.8 -1.3 -1.6 -1.5 -1.2 -1.9 -1.3 -0.5 -1.4 -1.3 -1.2 -0.5
Deep venous thrombosis (DVT) (self-reported) 1.7 2.2 4.0 1.7 1.5 -1.2 2.0 0.5 1.4 1.6 2.0 1.6 2.0 1.5 0.9 1.4 1.4 1.3 -0.3
Heart disease (siblings) 0.4 0.4 2.3 1.5 0.5 0.0 0.2 -0.5 0.6 0.5 0.6 0.3 0.8 0.5 0.9 0.5 0.6 0.8 0.1
Alcohol drinker status: Previous 0.7 0.8 3.0 1.3 0.8 -0.4 -0.5 0.4 1.0 0.9 0.6 0.8 0.7 0.9 1.7 1.0 1.0 1.0 -0.6
Pack years of smoking 2.2 3.2 5.1 1.8 2.2 -2.1 1.0 1.3 2.2 1.8 1.2 2.1 1.7 2.3 0.4 2.2 2.2 2.1 -1.1
Impedance of whole body 5.9 29.8 60.8 4.7 5.6 -5.3 7.8 5.2 5.0 5.8 7.5 6.3 6.8 5.1 0.2 5.0 5.0 5.1 -2.0
Leg fat mass (left) 0.6 2.2 5.9 -1.2 -0.9 1.9 -2.4 -1.5 -0.7 -0.9 -2.1 -1.2 -2.2 -0.8 2.4 -0.6 -0.7 -0.9 1.0
Arm predicted mass (left) 0.2 1.1 6.7 0.5 -0.3 0.4 -1.3 -2.6 -0.2 -0.2 -0.9 -1.0 -1.4 -0.3 1.6 -0.2 -0.2 -0.4 1.6