Hub : Genes

GLYCTK-AS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.156 0.0732 2.2e-03 0.143 NA 0.072 NA 0.087 8.1e-06 NA 1.4e-03 NA 5.1e-04
2 GTEx Brain Cerebellum 0.091 0.0470 4.9e-03 0.136 NA 0.076 NA 0.125 8.0e-05 NA 3.0e-03 NA 1.6e-04
3 GTEx Brain Hippocampus 0.166 0.0659 2.6e-04 0.249 NA 0.122 NA 0.154 1.4e-06 NA 8.7e-04 NA 1.9e-04
4 GTEx Cells Transformed fibroblasts 0.074 0.0370 4.1e-03 0.014 NA 0.020 NA 0.016 2.9e-02 NA 1.1e-02 NA 2.2e-02
5 GTEx Esophagus Muscularis 0.046 0.0260 4.4e-03 -0.003 NA 0.002 NA 0.008 5.8e-01 NA 2.4e-01 NA 9.6e-02
6 GTEx Heart Atrial Appendage 0.061 0.0370 5.5e-03 -0.006 NA -0.006 NA -0.005 7.5e-01 NA 7.8e-01 NA 6.1e-01
7 GTEx Lung 0.110 0.0451 1.8e-07 0.090 NA 0.062 NA 0.088 2.1e-07 NA 1.8e-05 NA 3.0e-07
8 GTEx Spleen 0.319 0.1190 1.4e-05 0.085 NA 0.094 NA 0.059 3.4e-03 NA 2.2e-03 NA 1.3e-02
9 GTEx Thyroid 0.078 0.0370 3.8e-05 0.071 NA 0.080 NA 0.072 4.3e-06 NA 9.7e-07 NA 3.3e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 10.2 16.1 21.1 3.8 -4.1 3.5 3.0 4.3 4.2 4.6 3.9 4.5
Bipolar Disorder or Schizophrenia 13.9 33.8 47.8 4.9 -6.3 5.7 4.0 5.8 6.0 6.9 5.9 6.3
Depressed Affect (Nagel 2018) 1.0 2.2 4.4 1.2 -1.5 1.6 -0.2 1.8 1.9 1.3 0.3 2.1
Depression (Nagel 2018) 4.8 7.3 10.8 2.6 -2.3 2.6 2.4 2.9 3.3 2.7 2.2 3.1
Intelligence (Savage-Jansen 2018) 7.1 21.9 38.9 -4.5 4.3 -6.2 -2.6 -4.6 -5.9 -5.3 -3.7 -3.8
Neuroticism (Nagel 2018) 7.2 16.9 25.3 3.8 -4.1 4.1 2.4 4.6 4.9 4.3 3.0 5.0
Schizophrenia (2018) 8.6 17.9 27.0 3.2 -4.8 4.4 2.7 4.1 4.4 5.2 4.5 4.3
Schizophrenia vs Biploar Disorder 0.1 0.2 0.5 -0.7 -0.2 0.1 -0.5 -0.6 -0.4 -0.3 0.1 -0.2
Worry (Nagel 2018) 19.8 41.7 55.0 5.8 -6.4 6.3 5.1 6.8 7.2 6.9 5.9 7.4
Alzheimer’s Disease (in mother) 0.2 0.3 0.6 -0.0 -0.6 0.3 -0.8 0.4 0.3 0.7 0.1 0.8
Alzheimer’s Disease (in father) 0.1 0.1 0.7 -0.0 -0.5 0.8 -0.6 -0.1 -0.0 0.2 0.2 0.1
Alzheimer’s Disease (including proxy) 0.4 0.6 1.8 0.0 -0.8 1.3 -1.0 0.4 0.7 0.7 0.1 0.8
Crohns Disease (2017) 0.4 1.0 2.2 0.7 -0.4 1.4 0.6 1.2 1.3 0.5 -0.1 1.5
Irritable Bowel Disease (IBD) 1.1 2.5 4.1 1.5 -1.5 2.0 0.9 1.9 1.8 1.6 0.9 1.7
Ulcerative Colitis (UC) 0.8 1.6 2.8 1.0 -1.4 1.6 0.7 1.4 1.3 1.7 1.1 0.8
Major Depression (MDD) 3.4 4.2 8.1 1.6 -1.7 2.9 1.4 1.9 2.2 2.3 1.6 2.4
Reaction Time 0.0 0.1 0.2 -0.5 -0.2 0.4 -0.3 -0.3 0.1 0.1 -0.2 -0.3
Verbal and Numeric Reasoning (VNR) 7.3 17.6 26.2 -4.0 4.0 -5.1 -3.2 -4.1 -4.8 -4.8 -3.7 -3.7
Breast Cancer 0.9 2.0 4.0 -2.0 1.4 -1.9 -0.8 -1.2 -1.1 -1.7 -1.3 -1.0
Ovarian Cancer 0.4 0.6 1.4 0.4 -0.4 0.5 1.2 0.7 0.8 0.7 0.8 0.8
Prostate Cancer 1.5 2.1 3.9 2.0 -1.2 1.8 1.0 1.5 1.8 1.1 1.3 1.4
Age at First Birth 3.2 4.6 8.4 -1.9 2.3 -2.5 -0.7 -2.1 -2.9 -2.6 -1.4 -2.3
Bipolar Disorder (2011) 11.4 11.1 21.5 3.0 -2.8 4.6 1.4 3.2 4.1 3.7 2.4 3.6
Body Mass Index (BMI) (2010) 0.3 0.4 2.0 -0.2 0.2 -1.4 -0.6 0.0 -0.4 -0.7 -0.7 -0.2
Coronary Artery Disease (CAD) 0.1 0.1 0.3 -0.6 0.0 0.2 -0.3 -0.4 -0.0 -0.3 -0.4 -0.3
Crohns Disease (2012) 0.6 1.0 2.0 1.2 -0.4 1.4 1.0 1.1 1.2 0.4 0.2 1.4
Mean Putamen Volume 0.9 1.0 2.1 0.6 -0.6 1.0 1.4 0.8 1.4 0.8 0.7 1.3
Fasting Glucose 0.1 0.1 0.3 -0.1 -0.1 -0.5 0.2 0.3 -0.3 0.2 0.0 0.1
HbA1C 0.1 0.1 0.5 0.4 -0.1 0.2 -0.1 -0.5 -0.5 -0.1 -0.1 -0.7
HDL Cholesterol 2.5 4.1 11.9 -2.2 1.8 0.9 -3.5 -1.3 0.0 -2.0 -2.9 -1.4
LDL Cholesterol 2.2 3.5 11.7 -1.6 1.5 -3.4 0.8 -1.5 -2.3 -1.7 -0.6 -1.8
Lupus 0.1 0.1 0.3 0.0 0.3 -0.1 0.1 0.6 0.4 -0.3 -0.0 -0.3
Neuroticism (2016) 6.0 8.6 16.5 2.3 -3.0 2.7 1.6 3.5 3.2 3.0 2.2 4.1
Primary Biliary Cirrhosis 1.5 2.1 3.2 -1.4 1.5 -1.8 -0.4 -1.4 -1.8 -1.7 -1.1 -1.6
Rheumatoid Arthritis 1.5 2.1 3.2 -1.5 1.5 -1.0 -0.6 -1.7 -1.7 -1.6 -1.1 -1.8
Schizophrenia (2014) 10.9 24.1 36.1 3.8 -5.5 4.5 3.6 4.8 5.0 6.0 5.3 5.2
Triglycerides 1.5 2.4 4.5 1.8 -1.7 -0.8 2.1 1.3 0.5 1.9 2.0 1.2
Type 2 Diabetes (T2D) (2012) 6.2 7.1 12.7 2.5 -2.7 0.8 3.6 2.5 2.1 2.9 3.3 2.5
Ulcerative Colitis 2.8 4.0 6.8 1.7 -2.1 2.6 0.8 2.0 2.3 2.2 1.5 2.2
Blood Eosinophil Count 1.3 10.2 20.7 -2.9 2.6 -4.5 -0.1 -3.0 -4.3 -3.1 -1.5 -4.1
Blood Platelet Count 3.4 39.1 51.3 -7.2 6.5 -6.4 -3.2 -6.7 -6.7 -6.5 -5.8 -6.4
Blood Red Count 5.4 51.8 83.5 7.2 -7.8 7.3 5.0 7.2 7.3 9.1 7.5 5.6
Blood White Count 0.2 1.5 6.2 0.5 -0.2 -2.5 1.7 -0.1 -0.9 0.7 1.7 -0.6
Heel T-Score 0.1 1.0 3.9 -0.8 0.6 -2.0 0.7 -0.9 -0.9 -0.9 0.2 -1.1
BMI 5.2 29.9 46.4 -4.2 4.2 -6.8 -6.6 -4.5 -6.4 -6.0 -5.0 -4.8
Height 3.7 71.6 179.6 9.0 -7.0 13.4 2.5 8.9 10.9 7.6 4.9 7.0
Waist Hip Ratio (WHR) 20.2 91.0 139.2 8.9 -9.9 5.6 11.4 9.3 8.4 10.8 11.8 8.2
Systolic Blood Pressure 2.6 13.1 22.1 -3.7 3.5 -3.5 -1.4 -4.5 -4.7 -3.9 -2.7 -3.5
Smoking Status 5.8 13.8 32.4 -3.9 3.8 -5.7 -1.5 -3.1 -3.8 -4.2 -3.1 -3.0
Allergy or Eczema 0.2 0.6 1.8 0.4 -0.6 1.1 0.2 0.7 0.8 1.3 0.4 0.5
Cardiovascular Disease 0.8 2.7 5.9 -1.2 1.2 -2.4 -0.8 -1.5 -2.4 -2.0 -1.0 -1.4
Hypothyroidism (self reported) 1.7 4.0 6.2 -2.0 2.1 -0.3 -2.5 -1.9 -1.5 -2.0 -2.3 -2.3
Respiratory disease 0.3 0.6 1.5 -0.1 -1.0 1.0 -0.4 0.3 0.7 1.1 0.4 1.2
Type 2 Diabetes (T2D) (2018) 1.5 2.8 4.8 -1.6 1.1 -2.0 -1.3 -1.8 -2.2 -1.7 -1.0 -2.0
Lung FEV1/FVC ratio 2.1 10.6 18.1 -2.6 3.4 -3.2 -1.5 -3.5 -4.2 -4.2 -2.8 -3.1
Lung FVC 0.8 4.0 8.0 -2.4 1.9 -2.6 1.1 -2.3 -2.8 -2.2 -0.6 -1.1
Neuroticism 7.0 16.9 24.3 3.7 -4.2 4.5 1.7 4.6 4.9 4.5 3.1 4.8
Chronotype (morning person) 0.4 0.9 5.7 0.4 -0.9 -2.4 0.3 0.1 -0.8 0.3 0.9 0.1
Hair Pigment 0.0 0.5 1.6 -1.0 -0.1 -0.5 -1.3 -0.6 -0.8 0.0 -0.6 -0.2
Tanning 1.2 15.0 22.3 -3.6 4.1 -4.2 -3.3 -3.6 -3.9 -4.7 -3.9 -3.3
Hand grip strength (left) 0.6 1.6 5.3 0.9 -0.6 2.3 -0.8 1.3 2.2 0.9 0.0 0.6
Number of treatments/medications taken 0.5 1.0 6.2 -0.2 -0.2 -2.5 0.4 -0.2 -1.1 -0.7 0.6 0.2
Average weekly spirits intake 2.5 3.1 4.6 -1.4 1.9 -1.9 -1.8 -1.2 -1.7 -2.1 -2.2 -1.4
Sensitivity / hurt feelings 0.7 1.1 3.1 0.9 -0.6 1.5 0.7 1.2 1.8 1.1 0.5 0.5
Frequency of depressed mood in last 2 weeks 6.1 8.6 11.8 3.1 -2.7 2.2 2.6 3.4 3.3 2.8 2.5 3.4
Hearing difficulty/problems: Yes 1.0 1.5 5.4 0.9 -0.9 0.2 2.3 1.0 0.5 0.8 1.8 0.9
Relative age of first facial hair 0.3 0.5 1.4 -0.7 1.2 -0.0 -0.1 -0.7 -0.4 -0.9 -1.1 -0.5
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.8 0.5 -0.8 0.3 1.3 0.5 0.3 0.9 1.3 0.5
Ever used hormone-replacement therapy (HRT) 1.7 2.1 3.8 1.4 -1.6 -1.6 1.9 1.3 0.5 1.3 1.8 1.3
Ever had hysterectomy (womb removed) 0.5 0.6 3.0 0.4 -0.3 -1.7 0.9 0.2 -0.6 0.4 0.6 -0.2
Systolic blood pressure, automated reading 4.2 12.3 21.8 -3.6 3.4 -2.5 -2.2 -4.3 -4.7 -3.7 -3.1 -3.5
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 1.5 0.3 0.1 -0.4 1.2 0.2 -0.1 -0.3 0.5 -0.3
Angina 0.1 0.2 0.4 -0.2 0.3 -0.1 -0.1 -0.6 -0.6 -0.7 0.1 0.0
Medication for hormone replacement therapy 0.8 0.9 2.4 0.4 -0.6 -1.4 1.5 0.6 0.0 0.9 1.2 0.5
Vitamin and mineral supplements 0.6 0.8 1.5 0.3 -0.7 1.2 0.5 0.7 1.2 1.2 0.7 1.2
Supplements: Zinc 0.4 0.5 1.5 0.6 -0.8 -0.8 0.7 0.5 -0.1 0.4 1.2 0.5
Medication: Co-codamol 0.7 0.8 2.7 -0.1 -0.8 -0.3 1.6 0.3 0.1 0.6 1.4 1.2
Medication: Metformin 0.7 0.9 1.9 -0.4 0.6 -1.0 -1.0 -1.0 -1.4 -1.1 -0.5 -1.2
Diabetes (father) 0.1 0.2 0.5 0.1 -0.3 -0.7 0.3 -0.1 -0.6 0.2 0.6 -0.4
Diabetes (mother) 0.3 0.4 1.5 0.6 -0.3 0.5 0.7 0.8 1.2 0.6 0.3 0.2
Severe depression (siblings) 2.0 2.2 4.7 1.4 -1.2 0.5 2.2 1.5 1.6 1.4 1.7 1.4
Pack years adult smoking proportion 3.0 4.6 7.8 1.6 -2.6 1.1 2.1 1.8 1.6 2.8 2.8 2.4
Impedance of leg (right) 4.5 22.0 32.0 3.7 -4.0 5.2 5.5 3.8 5.6 5.7 4.7 3.5
Leg fat-free mass (left) 0.3 1.8 9.8 0.1 0.4 -0.8 -3.1 0.0 -1.0 -1.6 -1.5 -0.3
Trunk fat percentage 0.1 0.4 1.1 0.6 -0.9 0.4 -1.1 0.6 0.6 0.9 0.2 0.2
Hand grip strength (right) 0.8 2.1 6.7 -0.1 0.9 2.3 -2.6 0.1 1.6 -0.4 -1.7 -0.7
Townsend deprivation index at recruitment 0.3 0.4 1.8 -0.7 -0.1 -1.3 0.7 -0.1 -0.3 -0.4 0.4 0.3
Current tobacco smoking 0.7 1.1 3.6 -1.2 1.1 -1.9 0.5 -0.7 -1.1 -1.0 -0.4 -0.4
Average weekly fortified wine intake 0.6 0.7 3.7 0.1 0.1 1.9 -1.1 0.2 0.8 0.1 -0.4 -0.4
Maternal smoking around birth 0.9 1.3 3.5 0.6 -1.2 0.4 1.5 0.7 0.5 1.5 1.9 1.1
Fed-up feelings 1.0 1.8 3.2 1.4 -1.4 0.4 0.9 1.7 1.6 1.0 1.2 1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 2.8 3.8 7.0 1.7 -1.3 1.4 2.2 2.3 2.2 1.6 1.6 2.6
Relative age voice broke 4.0 6.2 9.0 -2.4 2.8 -2.5 -0.9 -2.8 -2.5 -3.0 -2.2 -2.7
Taking other prescription medications 1.3 2.0 4.3 1.2 -1.4 -0.2 2.0 1.2 1.0 0.7 2.1 1.7
Age when periods started (menarche) 7.9 18.9 26.6 -5.0 4.5 -2.4 -3.8 -4.6 -4.2 -5.2 -4.6 -4.4
Bilateral oophorectomy (both ovaries removed) 1.0 1.1 2.2 0.7 -1.2 -1.4 1.2 0.6 -0.2 1.2 1.5 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 3.2 -0.4 0.3 -1.8 0.2 -0.8 -1.5 -0.8 0.4 -0.6
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 3.6 0.8 -0.9 0.4 1.5 1.5 1.2 1.0 0.7 1.9
Qualifications: CSEs or equivalent 0.5 0.7 2.1 0.2 -0.2 1.4 -0.8 0.7 1.1 0.8 -0.2 0.9
Serious illness, injury or assault to yourself 3.8 4.6 8.4 2.3 -2.5 0.3 2.6 2.0 1.2 2.3 2.9 2.1
High blood pressure 2.0 5.7 8.1 -2.1 2.3 -1.9 -2.1 -2.6 -2.9 -2.8 -2.4 -2.0
Hayfever, allergic rhinitis or eczema 1.3 2.8 5.8 1.3 -1.7 1.6 1.1 1.8 1.6 2.4 1.5 1.7
Multivitamins +/- minerals 2.0 2.6 4.2 -1.5 1.4 -2.1 -0.6 -1.6 -2.1 -1.8 -1.1 -1.8
Stomach or abdominal pain in last month 5.5 6.8 9.1 2.7 -2.8 1.5 2.7 2.9 2.6 3.0 2.6 2.4
Supplements: Glucosamine 0.1 0.2 0.9 0.2 -0.1 -1.0 0.2 -0.0 -0.7 -0.4 0.3 0.1
Diverticular disease/diverticulitis (self-reported) 1.4 1.7 6.5 1.3 -0.9 -0.2 2.5 0.7 0.5 1.1 2.0 0.3
Medication: Atenolol 0.8 1.0 2.1 -1.0 0.6 -1.2 -0.7 -1.4 -1.4 -0.9 -0.5 -1.0
Medication: Levothyroxine sodium 2.6 4.4 6.0 -1.9 2.4 -0.2 -2.2 -2.3 -1.9 -2.3 -2.4 -2.5
Sitting height 1.9 13.8 39.5 3.6 -3.0 6.3 0.3 4.1 4.7 3.4 1.7 3.0
Chronic bronchitis/emphysema (father) 0.5 0.6 1.4 -1.2 0.8 0.6 -0.3 -1.0 -0.1 -0.3 -1.1 -0.5
High blood pressure (mother) 2.2 3.1 5.0 2.1 -1.9 0.6 1.6 2.2 1.9 1.5 1.5 2.0
Body mass index (BMI) 3.3 13.9 26.9 -3.0 2.7 -5.2 -4.1 -3.1 -4.8 -3.9 -3.0 -2.9
Impedance of leg (left) 5.3 25.8 36.6 4.2 -4.3 5.6 5.9 4.2 5.9 6.0 5.0 3.8
Leg predicted mass (left) 0.3 1.8 9.9 0.2 0.4 -0.8 -3.1 0.0 -1.0 -1.6 -1.4 -0.4
Trunk fat mass 0.1 0.5 2.9 0.6 -0.6 0.3 -1.7 0.6 0.3 0.3 -0.2 0.1
Waist circumference 0.6 2.3 4.6 1.7 -2.1 -0.4 0.9 1.7 0.4 1.6 2.1 1.4
Number of incorrect matches in round 2.0 3.3 9.4 1.1 -1.6 3.1 -0.6 1.4 2.2 1.9 0.6 2.2
Past tobacco smoking 5.5 10.1 14.9 3.5 -3.4 3.9 2.0 2.8 2.8 3.7 3.2 2.8
Alcohol usually taken with meals 1.3 2.1 4.4 2.1 -1.4 1.2 1.1 1.6 1.9 1.3 1.3 0.7
Nervous feelings 11.0 20.4 28.2 3.8 -4.2 5.2 3.7 4.7 5.3 4.8 3.8 4.9
Frequency of tenseness / restlessness in last 2 weeks 7.9 12.2 19.1 3.7 -3.3 2.9 2.5 4.0 4.0 3.4 2.9 4.4
Hearing difficulty/problems with background noise 2.9 4.6 6.3 2.0 -1.9 1.5 2.2 2.5 2.1 2.1 2.3 2.5
Hair/balding pattern: Pattern 2 0.5 0.6 2.0 -0.8 0.3 -0.3 -1.4 -0.5 -0.1 -1.2 -0.8 -0.4
Had menopause 0.4 0.5 1.0 -0.5 0.7 -0.5 -0.0 -0.7 -1.0 -1.0 -0.5 -0.7
Had other major operations 0.2 0.3 0.6 0.5 -0.5 -0.7 0.8 0.6 0.2 0.2 0.6 0.4
Forced vital capacity (FVC) 1.6 6.1 11.3 2.2 -2.2 3.4 1.6 2.6 2.8 2.2 2.0 2.7
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 3.2 -0.7 0.4 -1.8 0.2 -1.1 -1.7 -0.8 0.5 -1.2
Ever unenthusiastic/disinterested for a whole week 1.8 2.2 4.2 1.2 -1.8 -0.6 1.8 1.5 0.6 1.4 2.0 1.5
Qualifications: None of the above 0.3 0.7 1.6 -1.3 0.0 -1.1 -0.9 -1.0 -0.9 -0.4 -0.7 0.1
Financial difficulties in last 2 years 1.3 1.7 3.7 0.9 -1.4 -0.3 1.9 1.3 0.8 1.1 1.9 1.3
Mouth/teeth dental problems 0.2 0.4 0.8 -0.4 0.3 -0.9 -0.7 -0.5 -0.8 -0.9 -0.3 -0.3
Heart attack 2.3 2.9 5.3 -1.8 1.7 -1.5 -1.2 -2.3 -1.6 -1.6 -1.3 -2.2
Allergy 1.9 4.4 7.9 -1.9 2.1 -2.3 -0.8 -2.2 -2.3 -2.8 -1.7 -2.1
Pain all over the body in last month 1.6 1.7 2.6 1.0 -1.4 0.4 1.2 1.6 1.6 1.6 1.4 1.3
Diabetes (self-reported) 2.3 3.5 5.6 -1.5 1.8 -2.3 -0.8 -2.0 -2.4 -2.1 -1.1 -2.2
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 3.2 0.6 -1.2 1.8 0.9 1.4 1.6 1.6 1.2 1.2
Medication: Ramipril 1.1 1.4 3.0 -1.1 1.4 -0.5 -0.4 -1.2 -0.9 -1.5 -1.2 -1.7
Medication: Simvastatin 0.4 0.6 2.7 -0.5 0.2 -0.7 -1.7 -0.6 -0.7 -0.5 -0.9 -0.6
Fluid intelligence score 4.0 8.3 14.1 -2.6 2.9 -3.7 -1.6 -2.8 -3.3 -3.4 -2.3 -2.7
Illnesses of siblings 0.1 0.1 0.6 0.2 0.0 -0.6 -0.2 -0.2 -0.7 0.3 0.2 -0.2
Neuroticism score 4.8 10.1 15.0 3.0 -3.1 3.1 1.8 3.8 3.9 3.2 2.4 3.8
Weight 0.3 1.6 8.0 -0.0 0.4 -1.0 -2.8 -0.2 -1.1 -1.4 -1.2 -0.6
Impedance of arm (right) 6.3 29.5 51.6 4.2 -4.5 7.1 4.9 4.7 7.2 6.3 4.4 4.4
Arm fat percentage (right) 0.7 2.8 6.1 -1.5 0.8 -2.4 -2.5 -1.2 -1.9 -1.4 -1.4 -1.2
Trunk fat-free mass 0.2 0.9 4.4 0.6 0.2 0.2 -2.1 0.6 -0.4 -1.5 -0.9 0.1
Hip circumference 1.8 7.9 17.4 -2.3 2.3 -2.4 -4.2 -2.2 -3.0 -3.0 -3.1 -2.3
Time employed in main current job 0.5 0.5 2.4 -1.1 0.3 -1.6 0.4 -0.5 -0.6 -0.2 -0.3 -0.5
Alcohol intake versus 10 years previously 2.9 4.3 5.9 -2.4 2.3 -2.0 -0.8 -2.4 -2.4 -2.2 -1.9 -1.7
Father’s age at death 0.1 0.2 0.8 0.2 -0.2 0.9 -0.2 0.3 0.5 0.4 -0.0 -0.0
Worrier / anxious feelings 10.7 20.1 25.0 4.1 -4.5 4.2 4.0 4.6 5.0 4.6 4.5 4.8
Frequency of tiredness / lethargy in last 2 weeks 5.5 8.9 14.2 2.9 -2.9 1.5 3.1 3.5 3.0 2.7 2.9 3.8
Falls in the last year 0.5 0.6 1.4 0.7 -0.4 -1.0 1.2 0.8 -0.1 0.7 0.8 0.9
Hair/balding pattern: Pattern 3 0.3 0.5 1.5 -0.1 0.9 -1.2 0.1 -0.4 -0.6 -0.7 -0.3 -0.9
Number of live births 0.2 0.3 1.0 -0.6 -0.2 -0.2 1.0 -0.2 0.1 0.1 0.6 0.6
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 3.9 1.3 -0.9 2.0 1.1 1.3 1.4 0.8 1.0 1.4
Pulse rate 7.9 13.3 18.5 3.7 -3.7 2.6 3.1 3.8 3.5 4.3 4.1 3.7
Happiness 4.4 5.3 10.5 2.6 -1.9 2.8 -0.0 2.8 3.2 1.8 1.0 2.6
Noisy workplace 1.8 2.3 3.5 -1.7 1.9 -0.7 -1.3 -1.5 -1.2 -1.4 -1.7 -1.8
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.4 -1.2 0.6 -0.5 -0.7 -1.1 -1.1 -1.0 -0.8 -0.6
Serious illness, injury or assault of a close relative in last 2 years 3.2 3.7 6.4 1.8 -2.0 0.3 2.3 2.2 1.7 1.7 1.8 2.5
Mouth/teeth dental problems: Dentures 0.2 0.4 0.6 -0.5 0.8 0.0 -0.7 -0.8 -0.5 -0.8 -0.7 -0.2
Asthma 0.2 0.4 1.0 -0.0 -0.9 -0.3 0.4 0.3 0.4 0.7 1.0 1.0
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.7 0.6 -0.3 -0.7 -0.5 0.8 0.7 -0.2 -0.4 1.3
Medication: Cholesterol lowering 2.2 3.4 5.2 -1.5 1.7 -1.9 -1.8 -1.6 -1.6 -2.3 -2.0 -2.2
Depression (self-reported) 5.3 6.3 10.2 2.1 -2.5 2.2 2.1 2.8 3.2 2.0 2.2 3.1
Medication: Lansoprazole 1.8 2.1 3.4 1.2 -1.6 0.1 1.7 1.7 1.2 1.4 1.8 1.2
Prospective memory result 7.4 9.1 13.0 3.3 -2.8 3.4 1.7 3.3 3.6 3.2 2.2 3.1
Lung cancer (father) 0.1 0.1 0.6 -0.8 -0.3 0.2 0.2 0.1 0.3 0.4 -0.0 0.4
Illnesses of mother 1.9 2.4 3.8 -1.4 1.8 -1.3 -0.8 -1.9 -1.7 -1.7 -1.1 -1.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 3.6 1.8 -1.2 1.8 1.5 1.5 1.4 0.9 1.3 1.9
Pulse wave Arterial Stiffness index 0.9 1.0 3.5 -0.1 1.0 -1.2 -0.1 -1.1 -1.9 -0.9 -0.5 -0.7
Impedance of arm (left) 6.2 28.9 52.7 4.5 -4.4 7.3 4.5 4.7 7.2 6.3 4.2 4.1
Arm fat mass (right) 0.6 2.6 7.2 -1.0 0.7 -2.1 -2.7 -0.9 -1.9 -1.5 -1.3 -1.0
Trunk predicted mass 0.2 1.0 4.5 0.5 0.3 0.2 -2.1 0.5 -0.4 -1.5 -0.9 0.1
Standing height 3.6 35.7 77.8 6.5 -5.0 8.8 2.6 6.4 7.7 5.4 4.0 4.8
Length of working week for main job 0.3 0.3 0.9 -0.9 -0.1 -0.6 -1.0 -0.4 -0.4 -0.2 -0.2 -0.1
Exposure to tobacco smoke at home 0.4 0.5 2.0 -0.1 0.7 0.2 -1.4 -0.4 0.2 -0.6 -1.1 -0.2
Breastfed as a baby 3.2 3.9 6.7 -2.0 2.3 -0.9 -2.2 -2.1 -1.8 -2.1 -2.6 -1.6
Tense / ‘highly strung’ 7.3 12.0 16.8 3.6 -3.5 3.4 1.9 3.9 4.0 3.5 2.8 4.1
Seen doctor (GP) for nerves, anxiety, tension or depression 3.5 5.3 8.7 2.5 -2.1 2.2 1.0 2.7 3.0 2.6 1.5 2.4
Hair/balding pattern: Pattern 4 0.8 2.0 4.0 -1.5 1.1 -2.0 -0.9 -1.4 -1.8 -1.5 -1.1 -1.0
Birth weight of first child 0.3 0.5 2.5 0.4 -0.0 1.6 -0.2 0.4 1.0 0.5 -0.3 0.3
Peak expiratory flow (PEF) 0.1 0.2 1.0 0.4 0.0 1.0 -0.6 0.1 0.2 -0.0 -0.2 0.1
Pulse wave reflection index 1.9 2.4 6.0 -0.7 1.1 -2.1 -1.4 -1.4 -2.5 -1.8 -1.2 -0.5
Ever highly irritable/argumentative for 2 days 2.7 3.2 8.2 -1.4 1.7 -2.9 -0.2 -1.5 -2.5 -2.2 -1.3 -1.2
Loud music exposure frequency 0.2 0.2 0.6 -0.0 0.5 0.8 -0.0 -0.1 0.6 0.0 -0.5 0.3
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 2.1 0.8 -0.2 1.5 -0.5 0.7 0.7 0.5 -0.0 0.2
Mouth/teeth dental problems: Bleeding gums 3.0 3.8 7.2 2.1 -1.0 2.4 2.0 2.1 2.7 2.1 1.4 1.3
Blood clot in the leg (DVT) 2.0 2.6 5.3 1.8 -1.3 2.3 1.0 1.7 2.0 1.4 1.5 0.9
Medication: Paracetamol 5.6 9.3 12.3 3.1 -3.4 1.6 3.2 3.2 2.7 3.4 3.5 3.0
Headache pain in last month 7.4 12.7 16.9 3.7 -3.6 4.0 2.0 3.7 4.1 4.0 2.9 3.6
Medication for cholesterol, blood pressure or diabetes 2.3 3.8 5.8 2.0 -1.7 1.8 2.0 1.8 1.9 2.4 1.8 2.1
Glaucoma (self-reported) 4.6 5.4 8.2 1.9 -2.5 1.3 2.9 2.0 2.1 2.2 2.7 2.8
Gout (self-reported) 3.9 5.3 6.9 2.6 -2.5 1.9 2.1 2.4 2.2 2.4 2.2 2.3
Hypothyroidism/myxoedema (self-reported) 1.5 3.0 5.0 -1.8 1.8 -0.1 -2.2 -1.8 -1.4 -1.7 -2.0 -1.9
Medication: Amlodipine 1.1 1.5 3.3 -1.3 0.9 -1.8 0.4 -1.4 -1.8 -1.2 -0.3 -1.3
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.6 0.4 -0.8 -0.5 0.2 0.1 0.0 0.7 0.8 0.7
Birth weight 0.7 1.5 3.8 1.4 -0.7 1.9 0.7 1.6 1.5 0.8 0.4 1.1
Chronic bronchitis/emphysema (mother) 0.8 1.0 2.0 0.6 -0.9 1.4 1.0 0.8 1.4 1.0 0.7 0.8
High blood pressure (siblings) 0.1 0.2 0.8 -0.6 -0.1 -0.1 0.9 0.3 0.3 -0.2 0.3 0.2
Forced vital capacity (FVC), Best measure 1.9 6.8 10.2 2.6 -2.4 3.2 2.0 2.8 2.8 2.3 2.3 2.9
Body fat percentage 0.1 0.6 2.7 -0.3 -0.0 -1.0 -1.6 -0.3 -0.7 -0.1 -0.5 -0.6
Leg fat percentage (right) 1.2 4.5 10.5 -1.9 1.2 -3.2 -2.2 -2.0 -2.8 -1.7 -1.4 -1.8
Arm fat-free mass (right) 0.3 1.4 6.9 0.4 0.4 -0.6 -2.6 0.1 -1.1 -1.5 -1.2 -0.3
Exposure to tobacco smoke outside home 0.1 0.2 0.6 -0.5 -0.4 0.4 -0.2 0.0 0.2 0.4 -0.2 0.8
Comparative body size at age 10 1.6 4.4 9.5 -1.5 2.2 -3.1 -0.9 -1.8 -2.1 -2.6 -1.7 -2.2
Number of full brothers 1.1 1.4 3.2 -1.4 1.0 -1.8 -0.5 -1.1 -1.0 -1.3 -0.9 -1.0
Worry too long after embarrassment 3.4 5.7 9.0 2.4 -2.1 0.9 3.0 2.9 2.1 2.3 2.4 2.7
Seen a psychiatrist for nerves, anxiety, tension or depression 5.3 6.9 8.8 2.8 -2.6 1.8 2.5 3.0 2.9 2.8 2.5 2.7
Wheeze or whistling in the chest in last year 3.9 7.0 10.8 2.4 -2.9 1.7 1.8 2.9 2.8 3.1 2.5 3.3
Number of children fathered 0.8 0.9 3.0 -0.9 0.7 -1.7 -1.1 -0.6 -0.9 -0.9 -0.5 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.9 5.0 1.4 -1.1 2.2 -0.1 1.2 1.9 1.5 0.5 1.1
Age at first live birth 0.7 1.3 2.8 -0.2 1.4 0.1 -0.9 -1.2 -0.8 -1.4 -1.3 -1.7
Pulse wave peak to peak time 1.6 1.9 5.7 0.6 -1.3 1.8 0.2 1.6 2.4 1.3 0.8 1.1
Health satisfaction 1.1 1.4 2.9 1.4 -1.2 -0.3 1.3 1.3 0.7 0.7 1.4 1.7
Shortness of breath walking on level ground 0.3 0.4 1.2 1.1 -0.7 0.1 -0.0 0.9 0.4 0.5 0.3 0.8
Qualifications: College or University degree 2.4 7.6 12.8 3.6 -3.0 2.4 2.1 2.9 2.7 2.6 2.8 2.6
Eye problems/disorders: None of the above 2.6 3.0 5.0 -1.7 2.2 -2.2 -0.7 -1.5 -1.9 -1.8 -1.8 -1.3
Mouth/teeth dental problems: Loose teeth 1.4 1.7 2.9 0.8 -1.6 1.7 0.4 1.1 1.3 1.4 1.2 1.7
Emphysema/chronic bronchitis 0.3 0.3 2.4 -0.2 0.2 1.6 -0.1 -0.0 0.5 0.3 -0.1 0.2
Medication for pain relief, constipation, heartburn 4.1 7.0 11.6 -3.4 2.9 -0.6 -2.4 -2.9 -2.4 -2.4 -2.7 -3.2
Neck or shoulder pain in last month 1.3 1.8 4.1 1.2 -1.5 0.6 2.0 1.1 0.5 1.4 1.9 1.2
Medication: Blood pressure 2.6 4.7 7.0 -2.1 1.9 -1.5 -2.2 -2.2 -2.1 -2.6 -2.2 -2.4
Angina (self-reported) 0.1 0.2 0.5 -0.2 0.4 -0.1 -0.1 -0.7 -0.7 -0.7 0.1 -0.1
Migraine (self-reported) 1.5 1.8 8.2 1.2 -0.9 2.9 -0.3 1.1 1.5 1.4 0.5 0.7
Medication: Ibuprofen 0.5 0.6 2.1 -0.3 0.4 -1.5 -0.9 -0.1 -0.4 -1.0 -1.0 0.5
Medication: Allopurinol 1.8 2.4 3.1 1.4 -1.6 1.3 1.5 1.6 1.4 1.6 1.7 1.7
Medication: Omeprazole 2.7 3.2 7.0 1.4 -2.0 -0.7 2.6 1.8 0.8 1.4 2.4 2.1
Medication: Seretide 50 evohaler 0.1 0.1 0.4 -0.2 -0.1 -0.7 -0.1 -0.0 -0.6 0.1 0.3 -0.1
Mean time to correctly identify matches 0.4 0.8 1.8 -1.3 0.6 0.1 -0.8 -1.2 -0.8 -0.7 -1.0 -0.8
Heart disease (mother) 0.2 0.2 0.8 -0.2 -0.5 -0.9 0.1 0.1 -0.5 0.1 0.4 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.7 2.0 4.5 -2.1 1.3 -1.5 -1.2 -1.6 -1.4 -1.2 -1.3 -0.8
Whole body fat mass 0.2 0.7 4.0 -0.1 -0.0 -1.0 -2.0 -0.1 -0.8 -0.5 -0.6 -0.5
Leg fat mass (right) 0.8 3.2 7.3 -1.1 0.7 -2.6 -2.7 -1.1 -2.3 -1.6 -1.3 -1.3
Arm predicted mass (right) 0.3 1.5 6.7 0.3 0.5 -0.6 -2.6 0.0 -1.1 -1.6 -1.2 -0.5
Pulse rate, automated reading 4.3 13.8 22.5 3.6 -3.9 1.1 4.0 3.6 2.9 4.5 4.7 3.9
Alcohol intake frequency. 1.2 2.8 4.9 1.7 -2.2 0.7 1.3 1.4 1.0 2.2 2.1 1.8
Comparative height size at age 10 4.7 25.8 35.3 5.3 -4.9 5.9 2.9 5.4 5.9 5.1 4.4 5.2
Number of full sisters 0.5 0.6 2.1 -1.4 0.6 -0.5 -0.4 -1.0 -0.9 -0.4 -0.6 -0.6
Suffer from ‘nerves’ 7.5 11.8 16.8 3.2 -3.4 3.5 2.0 4.0 4.1 3.6 2.4 4.1
Overall health rating 2.3 5.0 9.4 1.6 -2.3 0.3 3.1 2.0 1.5 2.0 3.0 2.9
Chest pain or discomfort 4.1 5.9 8.8 2.3 -2.4 3.0 1.5 2.4 2.5 2.6 2.1 2.7
Had major operations 0.8 0.9 1.4 -0.8 1.2 -1.0 0.8 -1.1 -1.0 -1.1 -0.4 -1.0
Age at last live birth 0.1 0.2 0.5 -0.1 0.4 0.3 0.1 -0.5 0.1 -0.7 -0.3 -0.7
Family relationship satisfaction 4.4 5.4 12.9 2.8 -1.1 2.6 1.1 3.1 3.6 2.1 0.9 1.9
Leg pain on walking 0.3 0.3 1.1 -0.0 0.6 -0.4 0.4 -0.6 -1.1 -0.6 0.0 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.4 0.3 -0.2 0.6 0.4 0.2 0.3 0.6 0.4 -0.5
Commuting to job workplace: Car/motor vehicle 0.2 0.2 1.2 -0.4 -0.1 0.3 -1.1 -0.1 -0.1 -0.1 -0.5 0.6
Illness, injury, bereavement, stress in last 2 years 5.5 6.7 9.4 -2.7 3.0 -0.6 -2.7 -2.9 -2.2 -2.8 -3.1 -2.6
Medication: Aspirin 0.3 0.4 1.7 1.3 -0.6 -0.7 -0.3 0.4 0.1 0.3 0.1 0.5
Supplements: Vitamin C 0.1 0.1 0.2 0.5 -0.2 -0.4 0.5 0.3 -0.2 -0.0 0.2 0.4
Knee pain experienced in last month 0.2 0.3 1.0 0.0 0.3 -1.0 0.4 -0.3 -1.0 -0.3 -0.0 -0.4
Hypertension (Self-reported) 2.1 5.7 9.3 -2.3 2.2 -2.0 -2.0 -2.8 -3.0 -2.8 -2.3 -2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.5 -0.4 -0.6 0.0 0.3 0.5 0.4 0.7 0.4 0.3
Illnesses of father: Heart disease 0.7 1.0 2.6 -1.1 0.9 -1.6 -0.5 -1.0 -1.2 -1.0 -0.7 -0.5
Illnesses of siblings: Diabetes 0.9 1.1 2.4 -0.8 1.5 -0.5 -0.3 -1.0 -1.0 -1.3 -1.0 -1.5
Smoking status: Previous 2.4 3.6 7.6 -2.0 2.0 -2.8 -1.2 -1.4 -1.5 -2.3 -2.0 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 2.3 4.8 15.8 1.7 -1.7 4.0 0.4 2.0 2.8 2.3 1.2 1.7
Whole body fat-free mass 0.2 1.1 6.1 0.6 0.2 -0.2 -2.5 0.5 -0.6 -1.4 -1.0 0.0
Leg fat-free mass (right) 0.3 1.4 8.1 0.6 0.2 -0.5 -2.8 0.4 -0.7 -1.3 -1.2 -0.1
Arm fat percentage (left) 0.6 2.5 6.8 -1.3 0.7 -2.2 -2.6 -1.1 -1.8 -1.2 -1.4 -1.1
Average weekly red wine intake 0.4 0.6 2.8 -0.1 0.4 -0.9 -1.7 -0.4 -0.3 -0.6 -0.8 -0.6
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.2 0.9 -1.1 0.1 0.4 1.1 0.7 0.6 0.8 0.8
Mood swings 2.7 4.8 7.7 2.0 -2.3 2.4 0.4 2.8 2.8 2.0 1.2 2.7
Loneliness, isolation 0.6 0.8 1.6 1.0 -0.7 1.2 -0.4 1.1 1.2 0.8 0.2 0.8
Long-standing illness, disability or infirmity 0.6 1.0 3.1 0.2 -0.7 -1.6 1.8 0.4 -0.5 0.3 1.4 0.4
Ever had bowel cancer screening 0.6 0.7 1.3 0.6 -0.7 0.8 1.1 0.8 0.9 0.5 0.6 1.1
Diabetes diagnosed by doctor 2.6 4.2 7.5 -1.8 1.8 -2.6 -1.0 -2.1 -2.7 -2.2 -1.2 -2.3
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.3 -0.3 -0.1 -0.6 0.5 0.2 0.2 0.1 0.5 0.0
Friendships satisfaction 2.4 2.9 8.6 1.7 -0.7 2.4 -0.5 2.3 2.9 1.2 -0.0 1.3
Qualifications: nursing, teaching 0.2 0.2 1.4 0.6 0.1 -1.2 0.3 0.4 0.1 -0.4 -0.0 0.1
Commuting to job workplace: Walk 0.6 0.6 1.5 -0.8 0.8 -0.5 1.2 -0.7 -0.6 -0.2 0.1 -1.2
Eye problems/disorders: Cataract 1.7 2.0 4.1 1.6 -1.6 2.0 0.4 1.1 1.8 1.3 1.5 0.8
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.1 0.0 0.2 -0.9 0.1 -0.1 -0.6 0.2 -0.3 -1.0
Medication for cholesterol 0.9 1.3 5.0 0.5 -0.2 2.2 -1.3 0.8 1.9 0.4 -0.8 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.2 2.6 4.8 1.9 -1.4 1.8 0.3 1.7 2.2 1.3 0.7 2.2
Back pain experienced in last month 0.7 1.0 2.3 -1.2 0.7 -1.2 0.6 -1.0 -1.5 -1.0 -0.0 -0.7
Mineral and other dietary supplements 0.8 1.1 6.2 0.2 -0.1 2.5 -0.2 0.4 1.6 1.0 0.2 -0.1
Breast cancer (self-reported) 0.1 0.1 0.3 0.2 -0.5 0.0 0.5 0.4 0.1 0.5 0.3 0.0
Asthma (self-reported) 0.3 0.7 1.6 0.1 -1.1 0.0 0.5 0.6 0.7 1.0 1.1 1.3
Osteoporosis (self-reported) 0.3 0.3 0.7 -0.7 0.9 -0.5 0.4 -0.7 -0.5 -0.6 -0.1 -0.5
Osteoarthritis (self-reported) 0.8 1.0 1.9 1.1 -1.4 -1.0 0.7 0.8 -0.3 0.7 1.3 1.4
Medication: Aspirin 0.1 0.1 0.7 0.8 -0.4 -0.6 -0.3 0.1 0.0 0.2 0.0 0.2
Medication: Gliclazide 0.2 0.2 0.5 0.6 -0.5 -0.1 0.2 0.3 0.3 0.7 0.6 -0.2
Illnesses of father: None of the above (group 1) 1.4 1.7 2.6 1.6 -1.4 0.6 0.9 1.6 1.2 1.5 1.2 1.3
Smoking status: Current 1.4 2.2 5.2 -1.8 1.6 -2.3 -0.0 -1.3 -1.6 -1.6 -1.0 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 1.7 -0.4 0.2 0.1 1.3 -0.4 -0.5 -0.6 0.4 0.5
Whole body water mass 0.2 1.2 6.2 0.5 0.2 -0.4 -2.5 0.4 -0.7 -1.5 -1.1 -0.0
Leg predicted mass (right) 0.3 1.3 7.8 0.6 0.2 -0.5 -2.8 0.4 -0.7 -1.3 -1.1 -0.1
Arm fat mass (left) 0.7 2.8 8.5 -1.0 0.7 -2.2 -2.9 -0.9 -1.9 -1.6 -1.4 -1.1
Number of self-reported non-cancer illnesses 0.3 0.5 1.3 -0.2 -1.0 -0.3 0.7 0.2 -0.0 0.5 1.1 1.1
Average weekly champagne plus white wine intake 4.9 6.7 10.0 -2.3 3.1 -2.6 -1.7 -2.4 -2.1 -3.2 -3.0 -2.6
Miserableness 0.2 0.4 1.0 -0.6 0.1 -1.0 -0.7 -0.1 -0.5 -0.4 -0.8 0.6
Guilty feelings 3.9 5.9 9.0 2.1 -2.1 2.6 1.4 2.7 3.0 2.6 1.8 3.0
Wears glasses or contact lenses 6.7 7.7 10.8 -3.1 2.8 -1.6 -2.8 -2.9 -2.8 -3.3 -2.9 -2.6
Ever taken oral contraceptive pill 0.2 0.2 1.5 -0.1 -0.4 -1.2 -0.1 0.3 0.1 0.2 0.0 -0.2
Hearing aid user 3.1 3.5 5.6 -2.2 1.6 -1.8 -1.2 -1.9 -2.4 -2.0 -1.3 -2.1
Mother’s age at death 1.1 1.4 4.3 -1.0 1.3 2.1 -0.8 -1.0 0.0 -0.6 -1.4 -1.2
Financial situation satisfaction 0.3 0.4 1.0 0.6 -0.1 0.2 1.0 0.8 0.9 0.1 0.1 0.8
Tinnitus: Yes, now most or all of the time 3.2 3.7 5.8 1.9 -2.0 2.2 1.0 1.9 1.9 2.4 1.8 2.0
Commuting to job workplace: Public transport 0.2 0.3 1.2 1.1 -0.1 0.0 0.2 0.4 0.8 0.3 0.1 -0.2
Eye problems/disorders: Glaucoma 1.9 2.3 4.4 0.7 -1.6 1.4 2.1 1.0 1.4 1.5 1.7 1.9
Medication: Blood pressure 1.3 2.4 6.3 -1.5 1.3 -1.7 -0.3 -1.8 -2.5 -1.7 -0.9 -1.3
Pain type(s) experienced in last month: Hip pain 1.0 1.2 2.0 1.3 -1.1 -1.4 0.8 1.3 0.2 0.8 1.1 1.4
Supplements: Fish oil (including cod liver oil) 0.5 0.7 3.4 -0.1 -0.0 -1.8 0.1 -0.4 -1.2 -1.1 -0.1 0.1
High cholesterol (Self-reported) 0.6 1.0 2.5 -0.8 0.5 -1.1 -1.3 -1.0 -1.6 -1.1 -0.7 -0.6
Medication: Bendroflumethiazide 1.8 2.7 5.8 -1.8 1.2 -2.0 -0.2 -1.7 -2.4 -1.6 -1.0 -1.8
Medication: Paracetamol 2.6 4.1 5.6 2.0 -2.4 0.9 2.1 2.2 1.8 2.1 2.3 2.0
Medication: Lisinopril 1.5 1.9 3.6 -0.9 1.1 -1.2 -1.7 -1.5 -1.6 -1.2 -1.0 -1.9
Medication: Atorvastatin 0.5 0.6 1.5 -0.5 0.7 -0.4 0.5 -1.0 -1.2 -1.0 0.1 -1.1
Illnesses of father: High blood pressure 1.4 1.7 3.1 -1.8 1.3 0.2 -0.8 -1.8 -1.5 -1.6 -0.9 -1.2
Alcohol drinker status: Never 0.6 0.7 1.2 1.1 -0.9 0.7 0.4 0.6 1.1 0.6 0.8 0.8
Ever smoked 7.1 12.5 16.9 -4.0 3.9 -3.9 -2.1 -3.1 -3.3 -4.1 -3.7 -3.2
Basal metabolic rate 0.2 1.1 6.2 0.6 0.1 -0.4 -2.5 0.5 -0.6 -1.3 -0.9 0.0
Leg fat percentage (left) 1.2 4.2 9.3 -1.7 1.2 -3.0 -2.2 -1.9 -2.8 -1.7 -1.3 -1.8
Arm fat-free mass (left) 0.2 1.0 4.7 0.6 0.1 -0.6 -2.2 0.5 -0.9 -1.4 -0.8 0.1
Number of operations (self-reported) 0.4 0.6 2.0 0.3 -0.7 -0.5 1.4 0.9 0.6 0.7 0.9 0.7
Average weekly beer plus cider intake 0.6 0.8 1.6 -1.2 0.8 1.1 -1.2 -1.0 -0.7 -0.2 -1.0 -0.3
Irritability 1.0 1.7 6.7 -0.7 0.8 -1.3 -2.6 -0.3 -0.6 -1.3 -1.8 -0.7
Risk taking 3.3 4.9 8.2 2.9 -2.3 0.5 2.1 2.6 1.9 2.1 2.4 2.1
Ever had prostate specific antigen (PSA) test 0.2 0.2 1.1 -0.3 -0.0 0.1 -1.0 0.3 0.4 -0.3 -0.5 0.3
Fractured/broken bones in last 5 years 1.3 1.7 3.2 -1.4 1.5 -0.9 -0.4 -1.7 -1.8 -1.2 -0.8 -1.3
Age started oral contraceptive pill 0.2 0.3 1.7 0.6 -0.5 1.3 -0.1 -0.2 -0.2 -0.2 0.1 0.1
Diastolic blood pressure, automated reading 0.4 1.4 3.1 0.9 -1.5 0.7 1.2 0.6 -0.1 1.8 1.5 1.3
Ever depressed for a whole week 0.6 0.7 1.1 1.0 -0.8 -0.6 0.6 1.0 0.2 0.9 0.9 1.1
Unable to work because of sickness or disability 0.3 0.4 1.6 0.0 -0.7 0.0 1.3 -0.2 -0.4 0.8 0.8 0.4
Commuting to job workplace: Cycle 2.2 2.7 4.8 -2.2 1.9 -0.7 -0.9 -1.9 -1.4 -1.9 -1.5 -1.7
Myopia 2.6 3.8 6.5 -1.6 2.2 -2.6 -0.9 -2.0 -2.1 -2.3 -1.8 -1.7
Vascular/heart problems diagnosed by doctor 1.6 4.4 6.6 2.0 -2.0 1.8 1.6 2.5 2.5 2.6 1.9 1.8
Cholesterol lowering medication 0.2 0.3 1.0 0.3 -0.7 -0.1 0.3 0.1 -0.7 0.3 1.0 1.0
Medication: Omeprazole (e.g. Zanprol) 2.7 3.3 6.6 1.8 -1.9 -0.4 2.6 2.0 1.0 1.4 2.3 2.1
Pain experienced in last month 1.5 2.5 4.3 -1.5 1.9 -0.0 -1.9 -1.8 -0.6 -1.4 -2.1 -1.8
Supplements: Calcium 0.5 0.6 1.1 0.6 -0.9 0.4 1.1 0.7 0.6 0.5 0.9 0.8
Basal cell carcinoma (self-reported) 7.7 9.1 11.1 3.3 -3.1 2.0 2.3 3.3 3.1 3.2 3.3 3.1
Heart attack/myocardial infarction (self-reported) 1.5 1.9 3.9 -1.4 1.3 -1.3 -0.8 -2.0 -1.3 -1.3 -0.9 -1.8
Deep venous thrombosis (DVT) (self-reported) 2.3 2.9 6.1 2.0 -1.4 2.5 1.0 1.8 2.1 1.6 1.6 1.0
Heart disease (siblings) 0.2 0.3 0.9 0.8 -0.5 0.1 0.2 0.3 0.6 0.4 0.4 0.9
Alcohol drinker status: Previous 0.7 0.8 1.9 1.4 -1.0 -0.5 0.2 1.1 0.5 0.9 0.6 1.1
Pack years of smoking 2.0 2.9 5.4 1.2 -2.2 1.0 1.4 1.3 1.1 2.3 2.3 1.8
Impedance of whole body 7.1 36.2 57.8 5.1 -5.0 7.4 5.9 5.2 7.6 7.2 5.2 4.7
Leg fat mass (left) 0.7 2.9 6.9 -0.9 0.7 -2.5 -2.6 -1.0 -2.3 -1.5 -1.2 -1.2
Arm predicted mass (left) 0.2 1.1 4.5 0.4 0.2 -0.8 -2.1 0.3 -1.1 -1.5 -0.9 0.0