Best TWAS P=4.03e-14 · Best GWAS P=3.71e-18 conditioned to 2.34e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HTR4 | 0.06 | 0.03 | lasso | 4 | 0.03 | 4.3e-05 | -3.9 | -6.1 | 1.2e-09 | 0.02 | 0.66 | 0.01 | TRUE |
| 2 | GTEx | Pituitary | ABLIM3 | 0.27 | 0.02 | lasso | 5 | 0.07 | 6.3e-03 | 3.4 | 5.4 | 8.3e-08 | -0.25 | 0.22 | 0.05 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | SPINK9 | 0.08 | 0.07 | enet | 21 | 0.07 | 1.4e-09 | -5.2 | -5.2 | 1.5e-07 | 0.06 | 0.07 | 0.92 | FALSE |
| 4 | YFS | Blood | ABLIM3 | 0.03 | 0.01 | blup | 575 | 0.02 | 2.4e-06 | 4.0 | 5.8 | 8.4e-09 | -0.03 | 0.89 | 0.00 | TRUE |
| 5 | YFS | Blood | ADRB2 | 0.09 | 0.05 | bslmm | 455 | 0.05 | 2.4e-15 | -5.3 | -7.6 | 4.0e-14 | 0.32 | 1.00 | 0.00 | TRUE |
| 6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FBXO38 | 0.04 | 0.04 | blup | 52 | 0.04 | 4.8e-03 | -4.2 | 5.6 | 2.0e-08 | -0.06 | 0.02 | 0.50 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | FBXO38 | 0.05 | 0.02 | lasso | 2 | 0.02 | 4.3e-02 | -5.0 | 5.7 | 1.4e-08 | -0.04 | 0.01 | 0.69 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FBXO38 | 0.02 | 0.03 | enet | 2 | 0.03 | 1.9e-04 | 4.1 | 5.1 | 3.0e-07 | -0.06 | 0.04 | 0.55 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FBXO38 | 0.03 | 0.01 | enet | 6 | 0.01 | 5.0e-02 | -4.5 | 6.3 | 3.8e-10 | -0.07 | 0.02 | 0.81 | TRUE |