[Hub]/) : Traits : Systolic Blood Pressure : →

chr1:752,566-2,761,863

Best TWAS P=1.19e-24 · Best GWAS P=1.04e-23 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ATAD3A	0.07	0.02	bslmm	285	0.02	7.4e-04	-2.38	5.1	3.0e-07	-0.26	0.21	0.12	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MXRA8	0.05	0.02	lasso	7	0.04	2.9e-05	-4.93	5.3	9.4e-08	0.10	0.97	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SLC35E2	0.35	0.15	enet	24	0.17	1.0e-20	7.32	-5.6	1.8e-08	0.71	1.00	0.00	TRUE
4	GTEx	Adipose Subcutaneous	NADK	0.06	0.04	lasso	3	0.04	2.7e-04	6.04	6.4	1.2e-10	-0.55	0.49	0.39	FALSE
5	GTEx	Adipose Subcutaneous	CPSF3L	0.13	0.03	lasso	3	0.06	2.7e-05	-6.61	-6.5	6.7e-11	-0.03	0.63	0.01	FALSE
6	GTEx	Adipose Subcutaneous	ANKRD65	0.27	0.10	lasso	9	0.15	5.7e-12	-6.56	5.8	6.6e-09	0.02	1.00	0.00	FALSE
7	GTEx	Adipose Visceral Omentum	ANKRD65	0.33	0.21	enet	16	0.25	4.1e-13	-6.02	5.7	1.6e-08	0.01	1.00	0.00	FALSE
8	GTEx	Artery Coronary	SAMD11	0.19	-0.01	lasso	2	0.00	2.6e-01	-5.20	-6.0	1.6e-09	-0.01	0.05	0.35	FALSE
9	GTEx	Artery Coronary	AL645728.2	0.18	0.03	lasso	3	0.00	4.2e-01	5.31	5.5	4.9e-08	-0.44	0.04	0.15	FALSE
10	GTEx	Artery Tibial	CPSF3L	0.08	0.00	lasso	4	0.00	8.9e-01	-4.73	-5.8	6.3e-09	-0.04	0.08	0.05	FALSE
11	GTEx	Brain Caudate basal ganglia	RP4-758J18.10	0.20	-0.01	lasso	5	0.03	5.6e-02	9.61	-8.1	4.2e-16	0.49	0.03	0.44	FALSE
12	GTEx	Brain Caudate basal ganglia	ANKRD65	0.23	0.06	enet	18	0.10	1.0e-03	-6.56	6.3	3.1e-10	0.00	0.09	0.05	FALSE
13	GTEx	Brain Cerebellar Hemisphere	NADK	0.18	0.11	lasso	7	0.09	3.1e-03	9.71	9.8	7.0e-23	-0.84	0.02	0.71	FALSE
14	GTEx	Brain Cerebellar Hemisphere	CPSF3L	0.25	0.09	lasso	2	0.06	1.1e-02	-6.45	-6.5	5.8e-11	-0.02	0.14	0.06	FALSE
15	GTEx	Brain Cerebellar Hemisphere	ANKRD65	0.56	0.16	lasso	10	0.20	9.4e-06	-5.64	7.2	5.9e-13	-0.02	0.42	0.04	FALSE
16	GTEx	Brain Cerebellar Hemisphere	RP5-890O3.9	0.24	0.02	lasso	9	0.02	1.3e-01	9.51	-9.7	4.1e-22	0.86	0.02	0.53	FALSE
17	GTEx	Brain Frontal Cortex BA9	ANKRD65	0.19	0.17	lasso	5	0.12	5.7e-04	-5.64	6.2	5.5e-10	0.00	0.22	0.04	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	GLTPD1	0.26	0.10	lasso	3	0.04	1.4e-02	-5.20	-5.7	1.4e-08	-0.05	0.08	0.05	FALSE
19	GTEx	Cells Transformed fibroblasts	ANKRD65	0.17	0.14	lasso	4	0.13	1.1e-09	-6.02	6.4	1.6e-10	0.00	1.00	0.00	FALSE
20	GTEx	Cells Transformed fibroblasts	CDK11B	0.10	0.06	lasso	4	0.05	2.1e-04	-1.41	7.2	6.6e-13	-0.86	0.01	0.98	FALSE
21	GTEx	Colon Sigmoid	ANKRD65	0.23	0.17	enet	27	0.18	7.3e-07	-6.02	5.2	1.6e-07	0.00	0.78	0.02	FALSE
22	GTEx	Colon Transverse	ANKRD65	0.17	-0.01	enet	3	0.00	6.0e-01	-6.56	6.5	7.4e-11	0.02	0.09	0.04	TRUE
23	GTEx	Colon Transverse	RP4-758J18.13	0.13	0.05	enet	16	0.04	6.1e-03	-5.20	6.2	5.7e-10	-0.25	0.06	0.10	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	ANKRD65	0.23	0.22	enet	22	0.18	3.4e-07	-6.56	5.3	9.0e-08	-0.06	0.90	0.00	FALSE
25	GTEx	Esophagus Mucosa	SDF4	0.05	0.00	enet	12	0.00	1.5e-01	-3.98	5.2	2.3e-07	0.08	0.10	0.06	FALSE
26	GTEx	Esophagus Mucosa	TMEM52	0.17	0.18	lasso	2	0.20	2.9e-13	9.30	-9.3	1.5e-20	0.78	0.69	0.31	FALSE
27	GTEx	Heart Atrial Appendage	NADK	0.19	0.00	lasso	5	0.00	3.1e-01	7.32	6.7	1.6e-11	-0.62	0.03	0.32	FALSE
28	GTEx	Heart Atrial Appendage	ANKRD65	0.11	0.08	enet	7	0.09	1.0e-04	-6.60	5.9	3.4e-09	0.01	0.50	0.02	FALSE
29	GTEx	Lung	NADK	0.07	0.03	lasso	3	0.02	8.5e-03	-9.19	10.2	1.2e-24	-0.91	0.01	0.98	TRUE
30	GTEx	Muscle Skeletal	NADK	0.06	0.00	enet	9	0.00	1.3e-01	9.71	9.3	1.1e-20	-0.77	0.05	0.84	FALSE
31	GTEx	Muscle Skeletal	TMEM52	0.11	0.08	lasso	6	0.10	7.2e-10	9.44	-8.9	3.7e-19	0.78	0.30	0.70	FALSE
32	GTEx	Muscle Skeletal	RP4-758J18.13	0.12	0.09	lasso	5	0.09	1.8e-09	-6.02	6.2	4.8e-10	0.01	1.00	0.00	FALSE
33	GTEx	Nerve Tibial	CALML6	0.13	0.12	lasso	2	0.11	4.4e-08	5.24	5.3	9.3e-08	-0.46	1.00	0.00	FALSE
34	GTEx	Nerve Tibial	ANKRD65	0.32	0.13	enet	18	0.20	7.2e-14	-6.02	5.3	1.3e-07	0.00	1.00	0.00	TRUE
35	GTEx	Ovary	NADK	0.27	0.17	lasso	5	0.16	9.6e-05	6.04	6.5	8.9e-11	-0.57	0.09	0.37	FALSE
36	GTEx	Ovary	PRKCZ	0.36	-0.01	lasso	5	0.00	2.5e-01	-0.22	5.3	1.0e-07	-0.48	0.04	0.55	FALSE
37	GTEx	Pancreas	CALML6	0.21	0.08	lasso	4	0.06	2.2e-03	5.27	5.7	1.5e-08	-0.45	0.39	0.21	FALSE
38	GTEx	Pancreas	TMEM52	0.19	0.00	enet	30	0.00	2.6e-01	1.07	7.0	1.9e-12	-0.57	0.03	0.65	FALSE
39	GTEx	Pituitary	NADK	0.21	0.09	enet	15	0.07	9.5e-03	9.44	9.4	4.8e-21	-0.64	0.02	0.58	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	CALML6	0.17	0.10	lasso	2	0.10	3.4e-06	5.88	-5.8	7.7e-09	0.54	0.67	0.03	FALSE
41	GTEx	Skin Not Sun Exposed Suprapubic	TMEM52	0.19	0.18	lasso	4	0.14	2.6e-08	-9.19	-9.8	1.8e-22	0.87	0.04	0.96	FALSE
42	GTEx	Skin Not Sun Exposed Suprapubic	ANKRD65	0.35	0.23	lasso	5	0.25	8.5e-14	-6.02	6.7	1.7e-11	-0.02	1.00	0.00	FALSE
43	GTEx	Skin Sun Exposed Lower leg	CALML6	0.13	0.09	lasso	2	0.08	4.7e-07	6.23	-6.3	3.3e-10	0.55	1.00	0.00	FALSE
44	GTEx	Skin Sun Exposed Lower leg	TMEM52	0.17	0.14	lasso	7	0.15	2.0e-12	-9.26	-9.7	4.5e-22	0.86	0.25	0.75	FALSE
45	GTEx	Spleen	TMEM52	0.47	0.21	lasso	5	0.22	2.3e-06	5.31	6.1	1.3e-09	-0.53	0.22	0.42	FALSE
46	GTEx	Stomach	ATAD3B	0.38	0.05	lasso	7	0.08	1.6e-04	-4.06	5.3	1.3e-07	-0.06	0.17	0.04	FALSE
47	GTEx	Stomach	ANKRD65	0.20	0.05	enet	33	0.10	1.7e-05	-6.60	8.0	1.3e-15	-0.16	0.26	0.10	TRUE
48	GTEx	Testis	PUSL1	0.19	0.02	lasso	6	0.05	3.8e-03	-4.89	8.7	2.8e-18	-0.41	0.05	0.39	TRUE
49	GTEx	Testis	GLTPD1	0.24	0.00	lasso	5	0.01	1.7e-01	-2.47	-5.4	8.5e-08	-0.04	0.05	0.06	FALSE
50	GTEx	Thyroid	CPSF3L	0.09	0.03	lasso	3	0.03	4.2e-03	-6.45	-6.0	2.0e-09	-0.06	0.29	0.06	FALSE
51	GTEx	Vagina	CPSF3L	0.29	0.00	lasso	6	0.00	4.3e-01	-6.02	-6.6	5.3e-11	-0.04	0.04	0.09	FALSE
52	METSIM	Adipose	ANKRD65	0.15	0.12	lasso	9	0.13	1.7e-18	-6.20	6.3	3.9e-10	0.04	1.00	0.00	FALSE
53	METSIM	Adipose	NADK	0.07	0.02	bslmm	297	0.04	4.5e-07	5.61	5.7	1.2e-08	-0.62	0.18	0.80	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	CDK11A	0.11	0.04	bslmm	293	0.05	5.5e-07	9.78	7.4	1.2e-13	-0.45	0.03	0.94	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	CPSF3L	0.13	0.12	bslmm	247	0.12	2.2e-15	-6.56	-6.0	2.4e-09	-0.06	1.00	0.00	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	C1orf222	0.11	0.14	enet	18	0.14	1.8e-17	5.39	-8.1	5.1e-16	0.67	0.99	0.01	FALSE
57	ROSMAP	Brain Pre-frontal Cortex	SCNN1D	0.04	0.01	blup	240	0.02	4.0e-04	-5.00	-7.3	3.4e-13	0.17	0.86	0.01	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	MMP23B	0.05	0.04	lasso	2	0.03	1.9e-04	9.09	9.1	1.1e-19	-0.75	0.05	0.94	FALSE
59	ROSMAP	Brain Pre-frontal Cortex	RP4-758J18.2	0.05	0.05	lasso	3	0.05	8.3e-07	-6.30	6.3	2.3e-10	0.02	0.98	0.00	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	RP1-140A9.1	0.15	0.16	lasso	2	0.16	4.2e-20	6.32	-6.3	2.8e-10	0.54	1.00	0.00	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	ANKRD65	0.23	0.32	lasso	7	0.40	2.8e-55	-6.02	6.3	2.6e-10	0.02	1.00	0.00	FALSE
62	YFS	Blood	MRPL20	0.02	0.02	enet	12	0.02	5.7e-07	-6.60	-6.8	1.4e-11	0.10	0.85	0.01	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC441869	0.03	0.04	lasso	2	0.03	1.4e-07	-5.64	5.6	1.9e-08	-0.01	0.08	0.92	FALSE
64	The Cancer Genome Atlas	Glioblastoma Multiforme	LOC441869	0.10	0.10	lasso	2	0.06	5.1e-03	-5.64	5.5	3.8e-08	-0.01	0.00	0.86	FALSE
65	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC35E2	0.03	0.03	blup	35	0.01	7.0e-02	9.66	9.1	1.4e-19	-0.93	0.02	0.96	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM52	0.02	0.01	blup	37	0.02	6.6e-03	9.22	-9.4	5.4e-21	0.86	0.01	0.81	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC441869	0.03	0.02	blup	16	0.02	8.5e-04	-6.60	5.4	7.2e-08	0.03	0.00	0.99	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC35E2	0.03	0.00	blup	34	0.01	5.3e-02	9.61	-9.0	2.0e-19	0.81	0.01	0.70	TRUE
69	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LOC148413	0.11	0.09	lasso	2	0.06	3.5e-04	-5.64	5.7	1.1e-08	0.00	0.04	0.87	FALSE
70	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC148413	0.03	0.03	lasso	3	0.03	2.7e-04	-6.37	6.4	1.9e-10	0.02	0.01	0.99	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC441869	0.08	0.10	blup	16	0.11	1.7e-12	-6.02	5.8	5.1e-09	0.02	0.00	1.00	FALSE
72	The Cancer Genome Atlas	Brain Lower Grade Glioma	SLC35E2	0.04	0.03	lasso	5	0.05	1.4e-06	9.61	-7.2	8.9e-13	0.77	0.02	0.98	TRUE
73	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC441869	0.06	0.05	blup	16	0.05	1.3e-06	-4.73	5.7	1.6e-08	0.02	0.25	0.48	FALSE
74	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC441869	0.11	0.09	lasso	3	0.10	5.6e-05	-6.02	5.7	1.2e-08	0.04	0.01	0.96	FALSE
75	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC441869	0.06	0.11	lasso	4	0.11	2.5e-11	-6.60	6.6	3.4e-11	0.00	0.00	1.00	FALSE
76	The Cancer Genome Atlas	Rectum Adenocarcinoma	LOC441869	0.37	0.23	lasso	4	0.19	2.6e-05	-6.45	6.1	8.2e-10	0.03	0.00	0.98	FALSE
77	The Cancer Genome Atlas	Stomach Adenocarcinoma	LOC441869	0.04	0.07	lasso	5	0.06	4.3e-05	-6.45	6.4	1.9e-10	0.03	0.00	0.99	TRUE
78	The Cancer Genome Atlas	Thyroid Carcinoma	LOC441869	0.05	0.07	lasso	3	0.06	6.6e-07	-6.45	6.5	9.0e-11	0.02	0.00	1.00	FALSE