Best TWAS P=2.24e-11 · Best GWAS P=1.34e-10 conditioned to 0.432
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | HHIPL1 | 0.35 | 0.09 | enet | 25 | 0.14 | 3.9e-11 | -4.3 | -5.6 | 1.9e-08 | 0.12 | 0.87 | 0.13 | FALSE |
| 2 | GTEx | Artery Aorta | EML1 | 0.37 | 0.04 | lasso | 7 | 0.10 | 2.6e-06 | -4.7 | 5.5 | 3.1e-08 | -0.83 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Artery Tibial | EML1 | 0.14 | 0.08 | lasso | 7 | 0.11 | 4.9e-09 | 4.6 | 6.7 | 2.2e-11 | -0.81 | 0.02 | 0.98 | TRUE |
| 4 | The Cancer Genome Atlas | Esophageal Carcinoma | CYP46A1 | 0.20 | 0.00 | blup | 65 | 0.08 | 1.6e-03 | -1.7 | 6.2 | 5.4e-10 | -0.36 | 0.02 | 0.09 | TRUE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HHIPL1 | 0.05 | 0.02 | blup | 57 | 0.02 | 1.5e-03 | 6.2 | -5.1 | 2.9e-07 | 0.12 | 0.00 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DEGS2 | 0.03 | 0.01 | blup | 44 | 0.01 | 7.9e-03 | 5.5 | -5.4 | 6.3e-08 | 0.00 | 0.00 | 0.94 | TRUE |