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chr14:73,012,484-76,340,208

Best TWAS P=2.01e-14 · Best GWAS P=1.71e-10 conditioned to 0.753

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DLST	0.09	0.11	lasso	2	0.11	4.0e-13	-5.3	5.6	1.7e-08	0.04	0.14	0.86	FALSE
2	CommonMind	Brain Pre-frontal Cortex	EIF2B2	0.10	0.22	lasso	6	0.21	1.4e-25	-5.5	5.5	3.1e-08	0.03	0.47	0.53	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MLH3	0.09	0.14	lasso	10	0.15	3.6e-18	-5.3	5.4	6.0e-08	0.03	0.50	0.50	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TMED10	0.04	0.03	enet	12	0.01	1.1e-02	-5.8	-5.9	4.5e-09	-0.02	0.11	0.87	FALSE
5	GTEx	Adipose Subcutaneous	EIF2B2	0.14	0.22	enet	11	0.21	7.4e-17	-5.6	5.4	6.4e-08	0.04	0.47	0.53	FALSE
6	GTEx	Adipose Subcutaneous	RPS6KL1	0.09	0.12	lasso	3	0.10	2.5e-08	5.5	5.4	7.8e-08	0.06	0.52	0.48	FALSE
7	GTEx	Adipose Subcutaneous	RP11-950C14.3	0.13	0.19	enet	15	0.16	8.5e-13	-5.6	5.2	1.8e-07	0.06	0.46	0.54	FALSE
8	GTEx	Adipose Visceral Omentum	EIF2B2	0.16	0.16	enet	10	0.17	3.6e-09	-5.5	5.7	9.0e-09	0.05	0.40	0.60	FALSE
9	GTEx	Adipose Visceral Omentum	RP11-950C14.3	0.08	0.08	enet	6	0.04	3.1e-03	-5.5	5.5	4.6e-08	0.03	0.35	0.45	FALSE
10	GTEx	Adrenal Gland	RPS6KL1	0.21	0.13	enet	25	0.15	4.4e-06	5.8	6.4	1.2e-10	0.02	0.27	0.66	FALSE
11	GTEx	Artery Aorta	NEK9	0.05	0.06	enet	8	0.04	2.3e-03	-5.7	-6.0	1.9e-09	-0.03	0.18	0.65	FALSE
12	GTEx	Artery Aorta	MLH3	0.19	0.07	enet	12	0.02	3.9e-02	5.8	6.2	7.3e-10	0.05	0.23	0.41	FALSE
13	GTEx	Artery Aorta	PNMA1	0.23	0.12	enet	23	0.14	2.7e-08	-5.5	5.6	2.0e-08	0.18	0.01	0.98	FALSE
14	GTEx	Artery Coronary	RPS6KL1	0.10	0.18	lasso	2	0.12	5.5e-05	-5.6	5.6	2.0e-08	0.02	0.27	0.60	FALSE
15	GTEx	Brain Caudate basal ganglia	ZC2HC1C	0.15	0.05	lasso	2	0.05	1.8e-02	-5.7	5.6	1.9e-08	0.00	0.11	0.36	FALSE
16	GTEx	Brain Cerebellum	PNMA1	0.30	0.25	lasso	3	0.24	1.2e-07	-5.5	5.4	5.3e-08	0.11	0.02	0.98	FALSE
17	GTEx	Brain Hippocampus	YLPM1	0.30	-0.01	lasso	9	-0.01	8.4e-01	3.1	6.2	4.8e-10	0.02	0.05	0.25	FALSE
18	GTEx	Brain Putamen basal ganglia	ZC2HC1C	0.20	0.18	lasso	1	0.16	1.2e-04	-5.4	5.4	5.2e-08	0.02	0.19	0.61	FALSE
19	GTEx	Breast Mammary Tissue	EIF2B2	0.17	0.16	enet	9	0.18	1.4e-09	-5.6	6.0	2.0e-09	0.04	0.46	0.54	FALSE
20	GTEx	Breast Mammary Tissue	RP11-950C14.3	0.11	0.11	enet	17	0.09	1.7e-05	-5.6	5.7	1.5e-08	0.03	0.41	0.58	FALSE
21	GTEx	Breast Mammary Tissue (Female)	EIF2B2	0.25	0.24	lasso	5	0.18	4.0e-06	-5.6	5.6	2.0e-08	0.03	0.33	0.60	FALSE
22	GTEx	Breast Mammary Tissue (Female)	RP11-950C14.3	0.13	0.05	enet	12	0.06	6.9e-03	-5.5	5.4	5.4e-08	0.02	0.16	0.35	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	EIF2B2	0.14	0.19	lasso	3	0.21	2.1e-07	-5.5	5.5	4.2e-08	0.03	0.30	0.64	FALSE
24	GTEx	Cells Transformed fibroblasts	NEK9	0.07	0.08	lasso	4	0.06	4.6e-05	-5.8	-5.8	6.3e-09	-0.02	0.16	0.83	FALSE
25	GTEx	Cells Transformed fibroblasts	MLH3	0.07	0.03	lasso	2	0.02	1.8e-02	-5.5	5.5	4.5e-08	0.03	0.28	0.63	FALSE
26	GTEx	Cells Transformed fibroblasts	EIF2B2	0.11	0.07	lasso	2	0.06	4.8e-05	-5.5	5.4	6.2e-08	0.03	0.30	0.70	FALSE
27	GTEx	Cells Transformed fibroblasts	RPS6KL1	0.16	0.15	enet	12	0.15	2.8e-11	5.4	5.6	2.0e-08	0.07	0.49	0.51	FALSE
28	GTEx	Cells Transformed fibroblasts	RP11-950C14.3	0.08	0.07	enet	23	0.06	3.6e-05	-5.8	5.3	1.1e-07	0.03	0.17	0.82	FALSE
29	GTEx	Colon Sigmoid	EIF2B2	0.17	0.16	enet	15	0.12	6.2e-05	5.6	6.4	1.3e-10	0.05	0.29	0.62	FALSE
30	GTEx	Colon Sigmoid	PNMA1	0.23	0.10	lasso	4	0.08	1.1e-03	-5.5	5.5	4.0e-08	0.16	0.02	0.96	FALSE
31	GTEx	Colon Sigmoid	RP11-950C14.3	0.10	0.05	enet	17	0.05	9.0e-03	-5.6	5.8	8.7e-09	0.02	0.16	0.33	FALSE
32	GTEx	Colon Transverse	RP11-950C14.3	0.08	0.10	lasso	4	0.09	5.6e-05	5.7	5.9	2.8e-09	0.06	0.28	0.48	FALSE
33	GTEx	Esophagus Gastroesophageal Junction	EIF2B2	0.20	0.11	enet	18	0.07	1.2e-03	-4.9	5.4	5.6e-08	0.03	0.26	0.69	FALSE
34	GTEx	Esophagus Gastroesophageal Junction	PNMA1	0.18	0.08	lasso	5	0.06	3.3e-03	-5.5	5.8	6.6e-09	0.11	0.02	0.90	FALSE
35	GTEx	Esophagus Muscularis	DLST	0.12	0.03	lasso	7	0.02	1.4e-02	-4.7	5.1	3.1e-07	0.01	0.36	0.23	FALSE
36	GTEx	Esophagus Muscularis	EIF2B2	0.30	0.30	enet	34	0.30	9.1e-19	-5.5	5.9	4.0e-09	0.05	0.57	0.43	FALSE
37	GTEx	Esophagus Muscularis	PNMA1	0.21	0.14	lasso	2	0.14	1.1e-08	-5.5	5.5	3.7e-08	0.11	0.01	0.99	FALSE
38	GTEx	Esophagus Muscularis	RPS6KL1	0.10	0.11	lasso	2	0.09	3.1e-06	5.8	5.7	1.2e-08	0.06	0.32	0.66	FALSE
39	GTEx	Esophagus Muscularis	RP11-950C14.3	0.16	0.08	enet	18	0.06	1.1e-04	-4.9	5.5	3.3e-08	0.04	0.34	0.62	FALSE
40	GTEx	Heart Atrial Appendage	EIF2B2	0.20	0.16	lasso	6	0.15	3.4e-07	-5.3	5.4	6.4e-08	0.03	0.47	0.53	FALSE
41	GTEx	Heart Atrial Appendage	RP4-647C14.2	0.18	0.03	lasso	6	0.02	6.1e-02	6.4	-6.2	7.1e-10	-0.86	0.01	0.94	TRUE
42	GTEx	Heart Atrial Appendage	RP11-950C14.3	0.14	0.13	lasso	1	0.12	6.2e-06	-5.5	5.5	5.0e-08	0.02	0.40	0.57	FALSE
43	GTEx	Heart Left Ventricle	ACYP1	0.07	0.08	enet	15	0.08	2.9e-05	-5.5	-5.7	9.9e-09	-0.01	0.22	0.55	FALSE
44	GTEx	Lung	EIF2B2	0.08	0.04	enet	18	0.03	1.6e-03	-5.5	5.6	2.1e-08	0.03	0.37	0.47	FALSE
45	GTEx	Lung	RP11-950C14.3	0.04	0.05	lasso	4	0.04	3.0e-04	-5.6	5.7	1.3e-08	0.03	0.25	0.62	FALSE
46	GTEx	Muscle Skeletal	EIF2B2	0.07	0.06	enet	7	0.04	4.3e-05	-5.5	5.4	6.2e-08	0.03	0.35	0.63	FALSE
47	GTEx	Nerve Tibial	YLPM1	0.08	0.06	lasso	1	0.04	5.1e-04	5.7	5.7	1.5e-08	0.05	0.11	0.65	FALSE
48	GTEx	Nerve Tibial	EIF2B2	0.19	0.31	enet	8	0.30	2.0e-21	-5.6	5.4	8.3e-08	0.03	0.47	0.53	FALSE
49	GTEx	Nerve Tibial	RPS6KL1	0.17	0.24	lasso	6	0.19	2.3e-13	5.5	5.3	1.3e-07	0.06	0.56	0.44	FALSE
50	GTEx	Pancreas	ZC2HC1C	0.16	0.01	enet	31	0.04	1.1e-02	-4.3	-5.3	8.9e-08	-0.08	0.26	0.65	FALSE
51	GTEx	Prostate	RPS6KL1	0.26	0.10	lasso	3	0.17	4.6e-05	5.7	5.8	5.0e-09	0.07	0.10	0.73	FALSE
52	GTEx	Skin Not Sun Exposed Suprapubic	EIF2B2	0.09	0.06	lasso	6	0.02	2.1e-02	-5.6	6.3	3.3e-10	0.02	0.29	0.53	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	RPS6KL1	0.08	0.08	enet	11	0.07	1.5e-04	6.0	5.5	3.9e-08	0.04	0.11	0.88	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	RP11-950C14.3	0.07	0.03	enet	8	0.03	1.2e-02	-5.6	6.5	8.6e-11	0.05	0.19	0.50	FALSE
55	GTEx	Skin Sun Exposed Lower leg	EIF2B2	0.05	0.03	lasso	3	0.01	2.1e-02	-4.9	5.4	5.1e-08	0.04	0.23	0.43	FALSE
56	GTEx	Skin Sun Exposed Lower leg	RPS6KL1	0.15	0.13	lasso	4	0.12	1.8e-10	5.4	5.9	4.4e-09	0.06	0.50	0.50	FALSE
57	GTEx	Small Intestine Terminal Ileum	RPS6KL1	0.57	0.12	lasso	16	0.10	2.9e-03	5.7	5.8	5.9e-09	0.07	0.08	0.37	FALSE
58	GTEx	Spleen	ACYP1	0.27	0.00	lasso	4	0.01	1.5e-01	-5.0	6.8	1.3e-11	0.03	0.05	0.17	FALSE
59	GTEx	Spleen	NPC2	0.30	0.08	enet	10	0.06	1.5e-02	6.1	6.4	1.7e-10	0.02	0.03	0.86	FALSE
60	GTEx	Spleen	EIF2B2	0.25	0.20	enet	14	0.20	6.1e-06	-5.6	5.6	2.2e-08	0.04	0.29	0.65	FALSE
61	GTEx	Spleen	RP11-950C14.3	0.28	0.10	enet	13	0.06	1.6e-02	-5.3	6.1	8.0e-10	0.02	0.20	0.40	FALSE
62	GTEx	Spleen	RP11-316E14.6	0.25	-0.01	enet	13	0.00	2.8e-01	-5.4	-6.8	1.1e-11	-0.02	0.06	0.30	FALSE
63	GTEx	Stomach	EIF2B2	0.09	0.11	enet	5	0.06	4.9e-04	-5.6	5.5	4.5e-08	0.03	0.30	0.45	FALSE
64	GTEx	Testis	AREL1	0.20	0.14	enet	34	0.13	2.1e-06	5.8	6.2	4.3e-10	0.04	0.09	0.91	FALSE
65	GTEx	Testis	MLH3	0.10	0.01	lasso	2	0.01	1.8e-01	-5.7	5.3	9.5e-08	0.02	0.13	0.43	FALSE
66	GTEx	Testis	EIF2B2	0.26	0.33	enet	15	0.30	1.2e-13	-5.6	5.5	3.0e-08	0.03	0.47	0.53	FALSE
67	GTEx	Testis	PNMA1	0.31	0.19	lasso	8	0.18	2.5e-08	-5.5	5.9	4.2e-09	0.12	0.01	0.99	TRUE
68	GTEx	Testis	RP11-950C14.3	0.15	0.13	enet	14	0.13	1.8e-06	-4.5	5.2	2.6e-07	0.03	0.40	0.60	FALSE
69	GTEx	Thyroid	RPS6KL1	0.23	0.14	enet	14	0.14	1.3e-10	5.8	5.5	4.7e-08	0.06	0.33	0.67	FALSE
70	GTEx	Uterus	RPS6KL1	0.26	0.09	lasso	6	0.11	2.8e-03	5.4	6.0	2.0e-09	0.06	0.10	0.24	FALSE
71	METSIM	Adipose	ACYP1	0.03	0.02	blup	413	0.02	4.0e-04	-5.4	6.4	1.6e-10	0.03	0.24	0.74	FALSE
72	METSIM	Adipose	EIF2B2	0.12	0.18	lasso	1	0.18	1.7e-26	-5.3	5.3	1.0e-07	0.03	0.60	0.40	FALSE
73	METSIM	Adipose	LTBP2	0.07	0.02	enet	17	0.05	1.8e-08	-6.2	-5.7	1.2e-08	-0.01	0.02	0.98	FALSE
74	METSIM	Adipose	RPS6KL1	0.07	0.07	blup	386	0.06	1.3e-09	5.4	7.7	2.0e-14	0.03	0.49	0.51	TRUE
75	METSIM	Adipose	YLPM1	0.04	0.00	bslmm	380	0.01	2.7e-03	-2.5	5.8	8.5e-09	0.05	0.09	0.16	FALSE
76	NTR	Blood	MLH3	0.02	0.01	enet	10	0.01	3.0e-04	-5.3	5.9	2.7e-09	0.05	0.46	0.51	FALSE
77	YFS	Blood	EIF2B2	0.14	0.29	enet	40	0.30	8.6e-100	-5.6	5.5	4.5e-08	0.03	0.54	0.46	FALSE
78	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EIF2B2	0.03	0.04	enet	5	0.03	9.9e-04	-5.5	5.5	2.9e-08	0.03	0.03	0.79	FALSE
79	The Cancer Genome Atlas	Breast Invasive Carcinoma	EIF2B2	0.02	0.03	blup	29	0.04	6.3e-08	-5.6	5.9	4.5e-09	0.05	0.02	0.98	FALSE
80	The Cancer Genome Atlas	Breast Invasive Carcinoma	MLH3	0.08	0.08	lasso	6	0.10	7.2e-19	-5.5	5.9	3.5e-09	0.04	0.08	0.92	FALSE
81	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPS6KL1	0.03	0.02	lasso	3	0.02	8.5e-06	5.7	5.9	2.8e-09	0.05	0.01	0.99	FALSE
82	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	EIF2B2	0.05	0.06	enet	12	0.06	6.8e-04	-5.6	5.7	1.3e-08	0.03	0.02	0.89	FALSE
83	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MLH3	0.05	0.07	enet	3	0.06	8.9e-04	-5.6	5.6	2.2e-08	0.02	0.03	0.87	FALSE
84	The Cancer Genome Atlas	Colon Adenocarcinoma	EIF2B2	0.10	0.03	lasso	3	0.02	3.4e-02	-4.9	5.7	1.3e-08	0.05	0.02	0.82	FALSE
85	The Cancer Genome Atlas	Colon Adenocarcinoma	MLH3	0.07	0.08	enet	9	0.06	1.5e-04	5.3	6.0	1.8e-09	0.06	0.04	0.95	FALSE
86	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MLH3	0.06	0.13	enet	11	0.13	2.1e-14	-5.6	5.7	1.1e-08	0.04	0.08	0.92	FALSE
87	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MLH3	0.07	0.09	blup	43	0.08	3.9e-09	-5.5	5.6	1.9e-08	0.04	0.06	0.94	FALSE
88	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NEK9	0.02	0.02	blup	48	0.02	4.6e-03	-5.8	5.7	9.9e-09	0.02	0.02	0.71	FALSE
89	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPS6KL1	0.04	0.04	lasso	3	0.03	1.8e-04	5.8	6.3	3.4e-10	0.06	0.01	0.98	FALSE
90	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MLH3	0.07	0.07	blup	44	0.06	1.4e-04	-5.6	5.7	9.5e-09	0.03	0.03	0.91	FALSE
91	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACYP1	0.10	0.03	lasso	3	0.03	3.8e-04	-5.9	-5.9	4.7e-09	-0.02	0.02	0.97	FALSE
92	The Cancer Genome Atlas	Brain Lower Grade Glioma	EIF2B2	0.03	0.03	blup	30	0.04	4.8e-05	-4.3	5.9	2.9e-09	0.05	0.04	0.95	FALSE
93	The Cancer Genome Atlas	Brain Lower Grade Glioma	MLH3	0.15	0.05	blup	44	0.04	9.0e-06	-5.5	5.3	9.0e-08	0.04	0.08	0.92	FALSE
94	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	EIF2B2	0.04	0.03	enet	7	0.02	3.8e-02	-5.3	5.6	2.8e-08	0.07	0.02	0.67	FALSE
95	The Cancer Genome Atlas	Lung Adenocarcinoma	ACYP1	0.02	0.01	blup	38	0.01	3.2e-02	-5.5	-5.7	1.4e-08	-0.03	0.02	0.68	FALSE
96	The Cancer Genome Atlas	Lung Adenocarcinoma	EIF2B2	0.02	0.02	blup	29	0.04	3.5e-05	-5.3	5.8	5.7e-09	0.05	0.04	0.96	FALSE
97	The Cancer Genome Atlas	Lung Adenocarcinoma	MLH3	0.06	0.07	lasso	5	0.06	6.5e-08	-5.5	5.6	2.5e-08	0.02	0.04	0.96	FALSE
98	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EIF2B2	0.04	0.01	blup	30	0.02	1.1e-03	-5.5	5.2	2.1e-07	0.04	0.03	0.92	FALSE
99	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MLH3	0.09	0.12	lasso	4	0.12	6.0e-14	-5.4	5.6	2.1e-08	0.03	0.08	0.92	FALSE
100	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RPS6KL1	0.02	0.02	lasso	2	0.02	5.6e-03	5.8	6.2	6.6e-10	0.07	0.02	0.67	FALSE
101	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PGF	0.09	0.06	enet	4	0.06	2.5e-03	-5.6	-5.7	9.3e-09	-0.03	0.02	0.72	FALSE
102	The Cancer Genome Atlas	Prostate Adenocarcinoma	EIF2B2	0.05	0.07	lasso	2	0.07	7.2e-08	-5.3	5.4	6.1e-08	0.03	0.04	0.96	FALSE
103	The Cancer Genome Atlas	Prostate Adenocarcinoma	MLH3	0.09	0.13	lasso	1	0.12	7.5e-13	-5.5	5.5	3.4e-08	0.03	0.08	0.92	FALSE
104	The Cancer Genome Atlas	Rectum Adenocarcinoma	MLH3	0.22	0.01	blup	43	0.01	1.6e-01	-5.6	5.6	2.6e-08	0.04	0.02	0.33	FALSE
105	The Cancer Genome Atlas	Stomach Adenocarcinoma	EIF2B2	0.03	0.03	enet	9	0.04	1.1e-03	-5.6	6.0	2.3e-09	0.03	0.02	0.77	FALSE
106	The Cancer Genome Atlas	Stomach Adenocarcinoma	MLH3	0.07	0.06	blup	43	0.06	2.1e-05	-5.5	5.2	1.8e-07	0.02	0.06	0.93	FALSE
107	The Cancer Genome Atlas	Testicular Germ Cell Tumors	EIF2B2	0.15	0.14	enet	19	0.14	1.2e-05	-5.3	5.5	3.0e-08	0.03	0.03	0.97	FALSE
108	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MLH3	0.13	0.16	enet	14	0.13	3.4e-05	-5.3	5.6	2.5e-08	0.03	0.04	0.94	FALSE
109	The Cancer Genome Atlas	Thyroid Carcinoma	DNAL1	0.04	0.02	enet	11	0.02	4.8e-03	-5.5	5.6	2.4e-08	0.12	0.01	0.97	FALSE
110	The Cancer Genome Atlas	Thyroid Carcinoma	EIF2B2	0.04	0.04	blup	28	0.05	1.1e-05	-5.5	5.2	1.7e-07	0.02	0.03	0.96	FALSE
111	The Cancer Genome Atlas	Thyroid Carcinoma	MLH3	0.14	0.20	lasso	5	0.20	6.6e-19	-5.3	5.4	5.3e-08	0.03	0.10	0.90	FALSE
112	The Cancer Genome Atlas	Thyroid Carcinoma	RPS6KL1	0.20	0.17	lasso	2	0.17	5.3e-16	5.4	5.8	6.0e-09	0.07	0.06	0.94	FALSE