Hub : Genes

EML1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.068	0.025	8.8e-04	0.036	0.025	0.022	0.03	0.044	2.7e-05	0.00044	9.9e-04	0.00012	4.5e-06
2	GTEx	Artery Aorta	0.367	0.085	3.5e-05	0.042	NA	0.090	NA	0.103	2.4e-03	NA	1.2e-05	NA	2.6e-06
3	GTEx	Artery Tibial	0.144	0.042	3.0e-04	0.081	NA	0.091	NA	0.111	6.2e-07	NA	1.4e-07	NA	4.9e-09
4	GTEx	Colon Sigmoid	0.257	0.084	4.4e-03	0.003	NA	0.002	NA	0.021	2.5e-01	NA	2.8e-01	NA	6.0e-02
5	GTEx	Esophagus Mucosa	0.115	0.046	9.7e-03	0.022	NA	0.033	NA	0.033	1.2e-02	NA	2.9e-03	NA	2.6e-03
6	GTEx	Testis	0.123	0.052	8.8e-03	0.046	NA	0.060	NA	0.049	4.3e-03	NA	1.2e-03	NA	3.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.7	2.6	6.9	0.9	1.9	0.3	2.6	1.8	-1.1
Bipolar Disorder or Schizophrenia	1.5	3.6	9.2	2.1	2.4	1.1	3.0	0.4	-0.8
Depressed Affect (Nagel 2018)	2.6	5.6	16.3	3.9	-0.0	-0.8	4.0	-0.2	-1.2
Depression (Nagel 2018)	1.2	1.8	6.7	1.9	0.3	0.3	2.6	0.1	0.3
Intelligence (Savage-Jansen 2018)	0.6	2.0	5.0	2.2	0.8	1.3	2.0	-0.7	0.2
Neuroticism (Nagel 2018)	1.3	3.2	9.5	2.8	-0.3	0.1	3.1	-0.2	-1.2
Schizophrenia (2018)	0.9	1.9	3.9	2.0	1.5	1.2	1.8	-0.9	-0.1
Schizophrenia vs Biploar Disorder	1.4	1.8	4.9	1.0	1.1	1.2	-1.4	-2.2	-0.6
Worry (Nagel 2018)	0.5	1.0	3.8	0.5	-0.5	0.2	2.0	1.2	-0.7
Alzheimer’s Disease (in mother)	0.4	0.5	1.1	1.1	0.1	-1.0	1.0	-0.2	-0.1
Alzheimer’s Disease (in father)	2.2	2.4	5.8	-0.5	-2.4	-1.8	1.4	1.5	1.0
Alzheimer’s Disease (including proxy)	1.0	1.4	3.1	0.1	-1.4	-1.8	1.4	1.2	0.5
Crohns Disease (2017)	0.1	0.3	0.7	0.6	0.6	-0.2	0.1	-0.6	-0.8
Irritable Bowel Disease (IBD)	0.4	0.9	2.6	1.6	0.6	0.8	1.0	-0.8	-0.4
Ulcerative Colitis (UC)	0.7	1.3	4.2	2.0	-0.3	0.5	1.7	-0.6	-0.1
Major Depression (MDD)	0.7	0.9	3.2	0.0	1.8	1.0	0.7	0.8	0.1
Reaction Time	0.3	0.6	1.4	1.2	0.1	-1.0	-0.0	-1.1	-0.1
Verbal and Numeric Reasoning (VNR)	0.9	2.1	7.0	2.7	-0.1	0.3	2.0	-1.1	0.4
Breast Cancer	0.2	0.6	1.5	0.6	1.2	-0.4	1.1	0.4	-0.5
Ovarian Cancer	0.4	0.5	2.2	0.0	1.5	-0.3	0.7	0.3	0.5
Prostate Cancer	0.2	0.3	0.7	-0.7	0.8	0.3	0.3	0.8	0.2
Age at First Birth	0.9	1.4	3.5	0.9	-0.7	-1.3	-0.6	-1.1	-1.9
Bipolar Disorder (2011)	2.8	2.7	5.7	-0.3	2.4	0.4	2.0	2.2	-1.2
Body Mass Index (BMI) (2010)	0.2	0.3	1.3	0.3	0.3	0.2	-0.3	-1.2	-0.2
Coronary Artery Disease (CAD)	4.0	4.7	17.0	0.6	2.0	2.6	0.8	-0.2	-4.1
Crohns Disease (2012)	0.3	0.6	2.4	0.7	-0.2	0.0	0.5	-0.3	-1.5
Mean Putamen Volume	1.2	1.3	3.3	-0.7	1.2	1.3	-1.8	-1.0	0.1
Fasting Glucose	0.9	1.0	2.2	1.5	-1.4	-0.7	0.6	-0.6	-1.0
HbA1C	0.9	0.9	3.4	-0.1	-1.8	-1.4	0.1	0.4	0.2
HDL Cholesterol	1.8	3.0	8.4	-2.9	-0.7	-0.6	-2.9	0.6	0.4
LDL Cholesterol	0.1	0.2	0.4	0.5	-0.5	0.4	-0.2	-0.6	-0.0
Lupus	2.2	3.4	8.5	-2.1	-1.9	-2.9	-0.8	0.8	1.6
Neuroticism (2016)	1.3	1.9	4.5	1.8	1.3	0.8	2.1	0.1	-1.2
Primary Biliary Cirrhosis	1.3	1.9	6.0	1.7	1.3	0.8	2.5	0.1	0.2
Rheumatoid Arthritis	0.5	0.7	2.7	-1.0	-0.6	-0.3	-1.6	-0.4	0.2
Schizophrenia (2014)	2.4	5.2	11.3	2.3	3.4	2.6	2.7	-0.2	-0.6
Triglycerides	1.1	1.7	6.3	1.8	-0.1	-0.7	2.5	0.7	-0.1
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.0	1.4	0.8	0.7	0.3	-1.3	-0.3
Ulcerative Colitis	1.4	2.1	5.2	2.3	0.7	1.7	0.9	-1.7	0.4
Blood Eosinophil Count	0.2	1.5	3.4	0.4	1.7	1.9	-0.7	-1.1	-0.7
Blood Platelet Count	0.1	1.3	4.0	0.6	-0.9	-2.0	0.1	-0.1	1.6
Blood Red Count	0.2	2.0	6.9	2.0	0.0	-0.1	2.6	0.1	-1.1
Blood White Count	0.2	1.2	4.8	-0.2	1.6	0.0	-0.0	0.1	2.2
Heel T-Score	0.5	4.2	12.8	-2.6	-0.2	-1.0	1.2	3.6	1.8
BMI	0.2	1.1	2.6	-1.0	1.2	0.3	-1.2	-0.3	1.6
Height	0.2	4.2	10.2	-3.2	-1.6	0.6	-3.1	0.6	-1.2
Waist Hip Ratio (WHR)	0.4	1.7	6.1	0.1	-1.8	-2.5	0.5	0.4	-0.6
Systolic Blood Pressure	3.1	15.7	44.7	2.0	5.5	6.7	1.5	-0.3	-3.5
Smoking Status	0.3	0.7	3.2	0.3	0.6	-0.4	0.3	0.2	1.8
Allergy or Eczema	0.1	0.2	0.4	-0.7	-0.5	0.1	-0.7	-0.1	-0.3
Cardiovascular Disease	0.3	1.1	2.5	1.6	1.1	1.1	0.7	-1.2	-0.1
Hypothyroidism (self reported)	0.2	0.5	1.8	-0.1	0.2	0.7	-0.1	-0.7	1.4
Respiratory disease	0.2	0.4	1.8	-0.7	-0.3	-1.3	-0.2	0.2	0.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.5	-0.8	-0.7	-1.2	0.2	0.8	-0.9
Lung FEV1/FVC ratio	0.9	4.5	10.3	-2.7	-3.2	-1.6	-2.6	0.0	-0.4
Lung FVC	0.5	2.7	7.9	-0.2	2.2	2.8	-1.1	-1.3	0.7
Neuroticism	1.0	2.4	8.4	2.3	-0.5	0.1	2.9	0.1	-0.7
Chronotype (morning person)	0.3	0.6	1.4	-0.6	0.7	0.7	-0.3	0.9	-1.2
Hair Pigment	0.1	2.2	7.2	-0.4	0.5	1.6	-2.7	-1.4	0.9
Tanning	0.2	3.0	11.7	-1.5	-1.5	-0.8	-3.4	-1.0	0.7
Hand grip strength (left)	0.7	1.8	3.1	-1.3	1.1	1.7	-1.4	0.4	-1.8
Number of treatments/medications taken	1.3	2.3	5.6	2.4	1.2	-0.2	2.4	-0.9	0.4
Average weekly spirits intake	0.6	0.8	2.1	1.4	0.4	0.6	-0.2	-1.4	0.3
Sensitivity / hurt feelings	1.2	2.0	7.6	1.1	-1.0	-0.8	2.8	1.4	0.2
Frequency of depressed mood in last 2 weeks	2.5	3.5	9.8	2.6	1.1	0.2	3.1	-0.2	-1.7
Hearing difficulty/problems: Yes	1.0	1.6	5.9	2.4	-0.1	-0.1	0.8	-1.6	0.4
Relative age of first facial hair	0.2	0.5	0.9	-0.8	0.5	-0.8	0.3	0.6	-0.9
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.0	0.2	1.4	1.4	-0.1	-0.6	0.6
Ever used hormone-replacement therapy (HRT)	1.3	1.6	3.9	0.6	-1.5	-1.2	-1.2	-2.0	0.7
Ever had hysterectomy (womb removed)	1.0	1.1	3.4	0.9	1.8	1.0	0.8	0.1	0.8
Systolic blood pressure, automated reading	4.0	11.6	36.0	2.1	4.9	6.0	1.1	-1.0	-1.7
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.6	-0.1	-0.1	-0.8	-0.3	-0.5	0.1
Angina	1.5	2.0	7.1	0.8	-0.2	-0.2	1.9	0.6	-2.7
Medication for hormone replacement therapy	1.0	1.2	2.7	-1.6	-0.6	-1.0	0.6	1.6	0.2
Vitamin and mineral supplements	0.6	0.8	2.0	0.3	-0.3	0.9	-1.3	-1.4	-0.1
Supplements: Zinc	1.4	1.5	4.3	2.1	1.2	0.6	0.8	-1.3	-0.5
Medication: Co-codamol	0.4	0.5	1.6	0.1	0.9	1.3	0.4	0.1	-0.4
Medication: Metformin	0.2	0.3	1.2	-0.1	-0.5	-0.3	0.4	0.3	-1.1
Diabetes (father)	0.7	0.9	3.0	-1.0	0.6	0.7	0.8	1.7	0.2
Diabetes (mother)	0.7	0.9	3.6	-0.9	-0.6	-0.5	-0.2	0.7	1.9
Severe depression (siblings)	1.0	1.1	5.3	-0.2	-0.4	-0.8	0.8	0.5	2.3
Pack years adult smoking proportion	0.5	0.7	2.3	-0.3	-0.0	-0.1	1.4	1.5	-0.4
Impedance of leg (right)	1.3	6.2	10.9	2.5	-2.7	-3.2	0.9	-1.3	-3.3
Leg fat-free mass (left)	0.7	3.5	9.1	-3.0	0.6	2.1	-1.6	1.3	1.7
Trunk fat percentage	0.2	0.7	1.4	0.1	-0.9	-1.2	-0.8	-0.8	0.9
Hand grip strength (right)	0.9	2.5	7.1	-0.9	2.1	2.7	-1.5	-0.4	-0.8
Townsend deprivation index at recruitment	1.0	1.4	6.1	0.9	2.5	0.1	1.1	-0.3	-0.1
Current tobacco smoking	0.5	0.9	1.9	1.4	0.7	0.4	0.8	-0.6	1.3
Average weekly fortified wine intake	0.7	0.9	2.1	0.0	0.6	0.9	1.2	1.4	0.6
Maternal smoking around birth	1.2	1.7	5.1	2.3	-0.6	-0.7	1.5	-1.0	-1.0
Fed-up feelings	2.1	3.8	10.8	3.3	0.3	-0.3	3.0	-0.8	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	5.6	2.3	2.0	0.6	2.4	-0.4	0.1
Relative age voice broke	0.5	0.8	2.8	-1.7	0.3	-0.9	-0.8	0.7	-0.0
Taking other prescription medications	0.6	1.0	3.1	0.4	1.2	0.2	1.1	-0.1	1.8
Age when periods started (menarche)	0.2	0.5	1.1	0.0	0.3	-0.2	1.1	0.9	-0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.8	-0.4	-0.4	-0.4	-0.3	0.2	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	-0.4	-0.3	-0.9	0.4	0.3	-0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.7	0.4	-0.3	-0.2	1.3	0.9	0.3
Qualifications: CSEs or equivalent	0.7	0.9	3.1	-0.1	-0.7	-1.8	1.0	1.1	-0.1
Serious illness, injury or assault to yourself	1.2	1.4	4.0	-1.5	0.6	0.2	0.8	2.0	1.1
High blood pressure	0.3	0.9	3.0	1.7	0.9	0.3	0.8	-0.7	-0.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	-0.7	0.4	0.6	-0.6	-0.1	0.2
Multivitamins +/- minerals	0.9	1.2	4.2	-0.4	-1.4	-2.0	0.6	0.7	0.6
Stomach or abdominal pain in last month	0.5	0.6	2.1	0.5	0.4	-0.2	-1.1	-1.5	0.2
Supplements: Glucosamine	0.3	0.4	1.1	0.4	-0.7	-0.2	1.0	0.1	1.0
Diverticular disease/diverticulitis (self-reported)	2.8	3.4	11.8	2.1	-0.7	0.4	-1.4	-3.4	1.2
Medication: Atenolol	0.3	0.4	1.1	0.2	-0.8	-1.0	0.7	0.5	-0.3
Medication: Levothyroxine sodium	0.6	1.1	4.3	0.8	-0.3	0.6	-0.1	-1.0	2.1
Sitting height	0.3	1.9	3.8	-1.9	-0.5	1.7	0.1	1.6	-1.3
Chronic bronchitis/emphysema (father)	0.6	0.7	2.7	0.0	-0.2	-0.6	0.8	0.6	-1.6
High blood pressure (mother)	0.0	0.0	0.1	0.2	-0.3	0.3	0.1	-0.1	0.1
Body mass index (BMI)	0.2	1.0	3.3	-0.5	1.1	0.8	-0.6	-0.1	1.8
Impedance of leg (left)	1.2	5.7	9.5	2.6	-2.3	-3.0	0.7	-1.8	-3.1
Leg predicted mass (left)	0.6	3.3	8.8	-3.0	0.5	2.0	-1.6	1.3	1.7
Trunk fat mass	0.1	0.5	1.3	-0.5	-0.5	-0.4	-0.9	-0.3	1.1
Waist circumference	0.1	0.4	1.7	-0.2	-0.3	-0.7	-0.1	0.0	1.3
Number of incorrect matches in round	0.8	1.3	3.1	1.1	-0.3	-0.6	-0.6	-1.8	-1.7
Past tobacco smoking	0.2	0.3	0.8	0.7	-0.2	0.3	0.8	0.0	-0.9
Alcohol usually taken with meals	1.1	1.9	5.4	-2.2	0.0	0.7	-0.3	2.3	0.4
Nervous feelings	0.6	1.2	3.1	0.1	-0.2	-0.5	1.8	1.5	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.7	0.2	0.7	-0.1	1.6	0.9	0.6
Hearing difficulty/problems with background noise	2.0	3.2	9.6	3.1	-0.8	-0.9	0.5	-2.8	-0.3
Hair/balding pattern: Pattern 2	0.8	1.1	2.3	-0.6	0.0	-0.2	1.1	1.5	1.5
Had menopause	0.5	0.7	2.6	1.0	-0.1	0.3	-0.5	-1.6	0.4
Had other major operations	0.2	0.3	0.8	0.2	-0.5	-0.1	0.9	0.8	-0.0
Forced vital capacity (FVC)	0.2	0.9	2.5	-1.5	-0.0	0.8	-1.6	0.0	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.8	-0.5	0.4	-0.5	1.3	1.1	0.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	2.6	1.6	0.2	-0.1	1.3	-0.4	1.3
Qualifications: None of the above	0.4	0.9	2.1	1.4	0.2	-0.8	1.1	-0.5	-1.0
Financial difficulties in last 2 years	1.7	2.2	5.3	2.3	1.5	0.1	1.9	-0.9	-1.1
Mouth/teeth dental problems	0.7	1.0	4.1	-1.1	-0.4	0.3	-2.0	-0.8	0.3
Heart attack	2.5	3.2	9.5	0.5	-0.6	-0.4	2.6	1.6	-3.1
Allergy	0.1	0.2	0.6	0.2	-0.8	-0.4	-0.1	0.1	0.4
Pain all over the body in last month	0.2	0.2	0.4	0.4	0.4	-0.6	-0.0	-0.4	-0.5
Diabetes (self-reported)	0.5	0.7	2.7	0.6	-0.6	-0.6	0.2	-0.9	-1.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.0	-1.3	1.4	0.7	-0.3	1.0	1.1
Medication: Ramipril	0.6	0.8	2.7	0.5	0.6	-0.4	1.0	0.6	-1.6
Medication: Simvastatin	0.5	0.8	2.4	1.5	-0.0	0.4	1.1	-0.9	0.1
Fluid intelligence score	0.6	1.3	3.7	1.9	-0.3	0.5	1.7	-0.2	0.8
Illnesses of siblings	1.1	1.6	6.2	0.8	-0.7	-0.7	-1.3	-2.5	0.2
Neuroticism score	1.2	2.6	9.1	2.4	0.2	-0.1	3.0	-0.0	-0.7
Weight	0.2	1.0	1.7	-1.3	0.5	1.2	-1.0	0.4	1.2
Impedance of arm (right)	1.6	7.3	19.4	0.5	-4.1	-4.4	-0.5	-0.6	-2.6
Arm fat percentage (right)	0.2	0.7	2.1	0.1	-0.6	-1.4	-0.8	-0.5	0.8
Trunk fat-free mass	0.4	2.5	6.9	-2.0	1.1	2.6	-1.0	0.9	1.1
Hip circumference	0.1	0.5	1.7	-0.7	-0.0	0.4	-0.8	0.1	1.3
Time employed in main current job	1.1	1.3	4.3	-0.8	0.8	1.2	-2.1	-0.8	-0.2
Alcohol intake versus 10 years previously	1.2	1.8	5.5	1.3	-0.6	-0.6	2.3	0.8	-1.5
Father’s age at death	0.2	0.3	0.7	-0.2	-0.4	0.3	-0.7	-0.5	0.8
Worrier / anxious feelings	0.3	0.6	1.6	0.7	-0.6	-1.3	1.2	-0.2	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	3.2	1.8	0.5	-0.0	1.4	-0.9	-0.6
Falls in the last year	0.8	1.1	2.3	-1.4	-0.4	-1.0	0.1	1.1	1.5
Hair/balding pattern: Pattern 3	1.1	1.7	5.6	1.6	0.3	0.0	-0.8	-2.4	-1.0
Number of live births	0.9	1.2	3.8	1.3	-0.8	-1.0	-0.6	-1.9	-0.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	5.2	-2.3	-0.4	0.6	-2.3	-0.1	-0.0
Pulse rate	0.6	1.0	1.8	1.4	1.1	-0.3	1.1	-0.8	1.0
Happiness	2.3	2.8	9.2	3.0	1.4	0.3	1.2	-1.9	0.8
Noisy workplace	0.3	0.3	1.4	0.5	-0.1	-0.2	1.2	-0.0	-0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.8	-0.4	-0.2	0.8	1.6	1.9	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.2	1.1	0.5	0.1	0.3	-0.7	-0.8
Mouth/teeth dental problems: Dentures	0.2	0.4	0.9	0.7	0.4	0.6	0.9	0.3	0.5
Asthma	0.2	0.4	1.7	-0.4	0.2	-1.3	0.2	0.2	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	4.8	-1.8	1.5	-0.0	1.4	2.2	1.3
Medication: Cholesterol lowering	1.2	1.9	6.2	2.5	0.3	0.3	0.8	-1.6	-1.4
Depression (self-reported)	3.7	4.5	9.7	1.4	3.1	2.9	2.5	0.6	0.2
Medication: Lansoprazole	1.0	1.1	3.0	0.7	-1.1	-0.8	-0.8	-1.7	0.9
Prospective memory result	0.5	0.6	1.4	-1.2	-0.5	1.0	-0.9	0.4	-0.5
Lung cancer (father)	0.2	0.2	1.1	0.0	-0.2	-1.0	-0.1	-0.3	0.1
Illnesses of mother	1.0	1.3	3.1	-1.0	1.8	0.8	-1.2	0.2	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	6.0	-2.0	0.4	2.4	-1.9	-0.2	-0.0
Pulse wave Arterial Stiffness index	0.6	0.7	2.4	0.8	0.5	0.3	1.6	0.6	-0.5
Impedance of arm (left)	1.2	5.6	15.6	0.3	-3.8	-4.0	-0.4	-0.4	-1.8
Arm fat mass (right)	0.2	0.6	2.1	-0.7	0.0	-0.3	-1.0	-0.2	1.5
Trunk predicted mass	0.5	2.6	7.1	-2.0	1.2	2.7	-1.0	0.9	1.0
Standing height	0.2	1.9	4.7	-2.2	-1.6	0.9	-1.4	0.8	-0.7
Length of working week for main job	0.4	0.5	0.9	-0.7	-0.7	-0.9	0.3	0.8	-0.2
Exposure to tobacco smoke at home	0.9	1.0	2.4	0.8	-0.1	-1.4	0.9	0.4	-1.6
Breastfed as a baby	0.3	0.4	1.0	-0.6	1.0	0.3	-0.7	0.2	-0.8
Tense / ‘highly strung’	1.2	1.9	5.5	1.0	1.8	0.5	2.4	1.0	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	4.0	1.3	1.6	1.4	2.0	-0.2	2.0
Hair/balding pattern: Pattern 4	0.6	1.6	3.7	-1.9	-1.4	0.2	-1.3	1.0	1.0
Birth weight of first child	0.5	1.0	3.8	-0.8	-0.4	-0.6	0.9	1.9	0.4
Peak expiratory flow (PEF)	0.9	2.0	7.4	-1.6	-0.7	-0.1	-2.7	-1.0	-0.7
Pulse wave reflection index	1.1	1.3	3.4	-0.8	-1.8	-0.7	0.4	1.8	0.1
Ever highly irritable/argumentative for 2 days	1.3	1.6	3.0	1.2	1.5	1.7	-0.2	-1.3	-1.1
Loud music exposure frequency	0.3	0.3	1.5	-0.1	0.0	-0.3	0.7	-0.1	1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.3	0.4	-0.8	0.9	-0.5	-1.1	0.6
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	7.3	0.8	0.4	-0.5	2.7	1.6	-2.1
Blood clot in the leg (DVT)	0.9	1.1	3.1	-0.8	0.5	1.1	1.3	1.8	-0.1
Medication: Paracetamol	4.2	7.0	13.1	-2.6	-2.3	-3.6	0.1	2.3	3.5
Headache pain in last month	1.1	1.9	8.0	-0.1	0.2	-1.6	0.8	0.5	2.8
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	3.4	-1.8	0.5	0.9	-1.6	0.2	1.2
Glaucoma (self-reported)	0.7	0.8	2.2	0.7	-0.6	0.0	-0.5	-1.3	-1.5
Gout (self-reported)	0.8	1.1	2.5	-0.5	-1.3	-1.6	0.1	0.3	1.5
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	4.6	0.5	-0.4	0.4	-0.6	-1.5	2.1
Medication: Amlodipine	0.9	1.2	3.2	1.3	1.1	1.1	0.2	-1.8	-0.1
Medication: Ventolin 100micrograms inhaler	1.1	1.5	4.4	-1.3	-0.0	-0.8	0.7	2.1	-1.3
Birth weight	0.8	1.8	3.2	-1.8	-1.7	-1.0	-0.9	1.2	1.0
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.8	0.5	-1.2	-1.1	0.9	0.1	-1.3
High blood pressure (siblings)	0.9	1.3	4.3	-1.3	0.7	0.7	0.7	2.1	0.7
Forced vital capacity (FVC), Best measure	0.5	1.7	6.6	-1.1	0.7	2.6	-1.3	-0.4	-0.0
Body fat percentage	0.2	0.6	1.6	0.4	-0.8	-1.3	-0.6	-0.8	0.6
Leg fat percentage (right)	0.1	0.5	1.9	1.4	0.3	-0.6	0.4	-0.8	0.2
Arm fat-free mass (right)	0.6	3.2	8.7	-1.9	1.8	2.9	-1.1	0.6	1.5
Exposure to tobacco smoke outside home	0.6	0.8	1.7	1.2	-0.5	-0.3	0.6	-0.9	-1.3
Comparative body size at age 10	0.4	1.2	3.4	-1.5	0.3	0.4	-1.8	0.3	1.1
Number of full brothers	1.5	1.9	6.1	-1.2	-0.2	-1.1	1.3	2.5	-0.7
Worry too long after embarrassment	0.5	0.9	2.5	1.6	0.2	1.0	0.3	-1.3	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	4.1	1.0	1.9	2.0	0.4	-0.8	0.7
Wheeze or whistling in the chest in last year	0.4	0.7	2.7	0.2	1.6	-0.5	1.0	0.2	-0.5
Number of children fathered	1.0	1.2	4.2	0.2	-0.4	-0.2	1.3	1.0	2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.0	0.6	-1.4	-0.6	-1.0	-1.1	-0.0
Age at first live birth	0.5	0.9	2.8	-0.1	-1.2	-0.2	-1.7	-0.8	0.4
Pulse wave peak to peak time	0.7	0.8	2.8	-0.8	-0.6	-0.3	-1.7	-0.7	0.7
Health satisfaction	0.5	0.6	1.3	1.1	0.2	-0.6	0.7	-0.8	0.9
Shortness of breath walking on level ground	0.3	0.3	1.6	0.1	1.3	0.5	0.1	-0.1	0.0
Qualifications: College or University degree	0.6	2.0	3.6	-1.8	0.7	1.2	-0.6	1.9	1.7
Eye problems/disorders: None of the above	3.3	3.8	12.8	-2.9	-0.1	-0.8	0.8	3.6	0.4
Mouth/teeth dental problems: Loose teeth	2.6	3.1	9.3	-2.8	0.1	0.1	-3.0	0.4	1.2
Emphysema/chronic bronchitis	0.4	0.4	1.2	0.8	0.7	0.3	1.1	0.2	0.1
Medication for pain relief, constipation, heartburn	1.9	3.2	8.0	0.5	1.7	2.7	-0.9	-0.5	-2.8
Neck or shoulder pain in last month	0.1	0.2	0.3	0.4	0.5	-0.3	0.5	-0.5	-0.1
Medication: Blood pressure	0.7	1.3	2.8	1.6	-0.3	-1.0	1.7	0.0	-1.1
Angina (self-reported)	1.7	2.3	7.7	1.1	-0.3	-0.3	2.1	0.4	-2.8
Migraine (self-reported)	2.0	2.5	11.7	-0.7	-0.4	-0.5	1.1	1.1	3.4
Medication: Ibuprofen	1.5	1.8	3.7	-1.3	1.5	-0.1	1.6	1.9	0.6
Medication: Allopurinol	0.5	0.6	2.5	-0.7	-0.6	-0.6	-0.1	0.2	1.6
Medication: Omeprazole	1.5	1.7	5.2	-0.0	-2.3	-2.1	0.0	0.0	0.8
Medication: Seretide 50 evohaler	2.0	2.3	5.8	-1.3	1.2	0.1	-2.4	-1.1	2.0
Mean time to correctly identify matches	0.9	1.7	4.7	2.2	1.0	-0.2	0.0	-2.1	-0.2
Heart disease (mother)	2.2	2.6	4.7	2.2	-0.5	-1.5	1.6	-1.2	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	3.4	0.4	1.9	0.2	1.2	0.9	-0.4
Whole body fat mass	0.1	0.3	0.8	-0.3	-0.3	-0.4	-0.8	-0.4	0.9
Leg fat mass (right)	0.0	0.1	0.6	-0.0	0.1	0.1	-0.4	-0.2	0.8
Arm predicted mass (right)	0.6	3.3	8.2	-1.9	1.8	2.9	-0.8	0.8	1.8
Pulse rate, automated reading	0.2	0.7	1.2	1.1	0.9	1.1	0.3	-0.9	0.5
Alcohol intake frequency.	1.6	3.8	11.5	2.5	1.8	0.5	3.4	-0.4	-1.2
Comparative height size at age 10	0.3	1.7	5.2	-1.7	-1.3	0.2	-2.3	-0.1	0.4
Number of full sisters	0.9	1.1	2.6	1.4	0.6	-1.0	0.6	-0.6	-1.6
Suffer from ‘nerves’	0.8	1.3	4.4	-0.2	-0.4	-1.0	2.1	1.4	-0.6
Overall health rating	0.4	0.8	3.1	0.0	1.0	-0.8	0.0	-0.6	1.8
Chest pain or discomfort	1.6	2.2	4.5	2.1	1.3	-0.0	2.1	-0.4	-1.6
Had major operations	2.0	2.4	5.5	1.5	0.8	1.6	2.3	0.4	-1.8
Age at last live birth	0.4	0.5	1.6	-0.0	-1.3	-0.3	-0.5	-0.1	-1.1
Family relationship satisfaction	1.5	1.8	6.1	0.5	2.5	1.5	0.9	0.1	1.2
Leg pain on walking	0.7	0.9	2.0	1.4	0.6	1.1	1.3	-0.5	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.2	-0.3	-0.1	0.5	1.5	1.5	0.6
Commuting to job workplace: Car/motor vehicle	0.5	0.6	0.9	0.9	-0.5	0.6	-0.0	-1.0	-1.0
Illness, injury, bereavement, stress in last 2 years	1.4	1.8	4.6	-1.5	-1.8	-0.7	-2.1	-0.3	0.1
Medication: Aspirin	1.4	1.8	5.7	1.2	-0.8	-1.3	2.4	0.6	-1.1
Supplements: Vitamin C	1.2	1.4	4.3	-0.4	2.1	1.8	0.6	0.5	-0.3
Knee pain experienced in last month	0.5	0.9	2.8	-0.2	0.5	-0.2	1.2	0.8	1.7
Hypertension (Self-reported)	0.4	1.2	3.6	1.9	1.2	0.9	1.0	-0.7	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.5	1.9	0.1	-0.3	1.1	-1.2	1.2
Illnesses of father: Heart disease	3.0	4.1	8.6	1.4	2.0	2.9	2.4	0.5	-2.0
Illnesses of siblings: Diabetes	2.1	2.6	7.5	0.1	1.0	-0.2	2.7	2.6	0.0
Smoking status: Previous	0.1	0.1	0.3	-0.2	0.3	-0.0	-0.5	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	4.8	-2.2	-0.4	-0.1	-2.2	0.3	0.2
Whole body fat-free mass	0.5	3.0	6.3	-2.4	1.1	2.5	-1.3	1.0	1.4
Leg fat-free mass (right)	0.7	4.0	10.7	-3.3	0.8	2.1	-1.6	1.4	1.8
Arm fat percentage (left)	0.2	0.7	1.9	-0.1	-0.6	-1.4	-0.6	-0.2	1.3
Average weekly red wine intake	1.7	2.4	8.6	-2.2	-0.5	0.1	-2.9	-0.1	-0.9
Handedness (chirality/laterality): Left-handed	1.2	1.4	3.9	0.4	0.2	-0.9	2.0	1.4	-1.3
Mood swings	1.9	3.4	9.9	2.9	0.7	-0.2	3.1	-0.3	-1.1
Loneliness, isolation	3.3	4.6	17.4	2.3	0.9	0.0	4.2	0.9	-1.8
Long-standing illness, disability or infirmity	0.8	1.1	3.4	0.4	1.8	1.4	-0.1	-0.8	0.8
Ever had bowel cancer screening	1.2	1.4	3.1	1.8	1.5	0.8	1.4	-0.7	0.4
Diabetes diagnosed by doctor	0.2	0.3	1.5	0.1	-0.3	-0.2	0.2	-0.4	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.7	0.7	0.3	-0.8	0.7	-0.3	-0.8
Friendships satisfaction	1.0	1.3	4.9	0.5	0.2	-0.6	2.2	1.5	0.0
Qualifications: nursing, teaching	0.4	0.7	1.5	0.0	0.9	0.5	-0.9	-0.9	1.2
Commuting to job workplace: Walk	0.5	0.5	1.2	-1.0	1.1	-0.2	0.6	0.6	-0.1
Eye problems/disorders: Cataract	2.0	2.3	7.7	2.8	0.8	0.9	0.4	-2.1	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.0	1.0	0.1	-0.5	1.0	-0.2	-0.2
Medication for cholesterol	0.3	0.5	1.1	0.8	-1.0	-0.4	0.4	-0.2	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.5	1.0	-0.6	-0.3	-0.5	-1.6	0.8
Back pain experienced in last month	1.0	1.4	4.0	0.7	1.8	2.0	0.2	-0.9	-0.0
Mineral and other dietary supplements	0.4	0.6	1.5	-0.2	-0.2	-0.9	0.6	1.2	-0.8
Breast cancer (self-reported)	0.3	0.4	1.1	-0.1	0.1	-1.0	-0.8	-0.8	-0.3
Asthma (self-reported)	0.2	0.4	1.3	-0.4	0.2	-1.1	0.0	0.1	-0.8
Osteoporosis (self-reported)	0.8	1.0	2.7	0.9	1.3	1.6	-0.3	-0.8	-0.4
Osteoarthritis (self-reported)	1.8	2.4	4.6	-0.6	-1.9	-2.1	0.8	1.3	1.8
Medication: Aspirin	1.3	1.7	5.4	1.4	-0.5	-1.0	2.3	0.4	-1.3
Medication: Gliclazide	0.9	1.0	2.9	-0.8	0.8	0.6	1.1	1.7	-0.3
Illnesses of father: None of the above (group 1)	2.8	3.5	9.6	-0.6	-1.9	-3.1	-1.7	-1.2	1.7
Smoking status: Current	0.4	0.7	3.1	0.8	-0.1	-0.4	0.3	-0.4	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.0	-1.2	0.1	1.4	-0.7	-0.2	0.4
Whole body water mass	0.5	3.1	6.9	-2.3	1.3	2.6	-1.2	0.9	1.5
Leg predicted mass (right)	0.7	4.0	10.5	-3.2	0.8	2.1	-1.7	1.3	1.9
Arm fat mass (left)	0.2	0.8	3.0	-0.9	-0.0	-0.3	-1.0	0.0	1.7
Number of self-reported non-cancer illnesses	1.7	2.9	4.9	2.1	1.7	1.2	2.2	-0.6	1.8
Average weekly champagne plus white wine intake	3.4	4.7	10.1	-3.0	0.4	-0.6	-0.1	3.2	2.9
Miserableness	2.3	4.0	11.7	3.4	0.0	-1.0	3.3	-0.4	0.5
Guilty feelings	0.5	0.8	2.4	1.5	-0.2	0.4	1.4	-0.4	-0.5
Wears glasses or contact lenses	0.9	1.1	2.6	1.2	0.1	-0.5	1.1	-0.8	1.6
Ever taken oral contraceptive pill	0.2	0.3	0.6	-0.4	0.6	0.1	-0.7	-0.5	-0.5
Hearing aid user	1.0	1.2	2.5	1.1	-0.5	-0.4	-1.1	-1.6	1.2
Mother’s age at death	0.1	0.1	0.2	-0.3	-0.2	0.4	-0.2	0.3	-0.3
Financial situation satisfaction	0.7	0.8	2.8	0.8	0.6	-0.2	1.1	-0.1	1.7
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.4	0.9	0.4	-0.3	1.5	0.4	1.2
Commuting to job workplace: Public transport	0.4	0.5	1.5	-0.5	-0.3	-0.8	-0.1	0.5	1.2
Eye problems/disorders: Glaucoma	1.0	1.2	4.0	0.9	-0.3	-0.1	-0.9	-2.0	-1.3
Medication: Blood pressure	0.4	0.8	2.4	0.2	1.6	1.5	0.1	0.0	0.1
Pain type(s) experienced in last month: Hip pain	1.2	1.5	7.1	0.2	2.7	1.2	0.5	0.1	0.5
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.9	-0.3	0.3	1.4	-0.7	-0.5	0.9
High cholesterol (Self-reported)	1.3	2.3	6.5	2.4	0.8	0.7	-0.2	-2.6	-0.7
Medication: Bendroflumethiazide	1.7	2.6	7.2	2.7	1.3	0.7	1.6	-0.8	-1.8
Medication: Paracetamol	3.8	5.9	11.6	-2.5	-2.4	-3.4	0.4	2.2	2.6
Medication: Lisinopril	2.6	3.4	6.5	1.7	1.8	1.6	2.2	0.4	-2.5
Medication: Atorvastatin	0.8	1.0	4.5	0.8	2.1	0.7	0.2	-0.4	-0.3
Illnesses of father: High blood pressure	0.7	0.8	3.0	-0.2	1.7	1.0	0.3	0.8	-0.5
Alcohol drinker status: Never	1.5	1.8	6.8	0.5	-1.1	-2.6	-0.1	-0.7	1.4
Ever smoked	0.3	0.5	1.7	-0.7	0.1	-0.4	-0.7	0.0	1.3
Basal metabolic rate	0.5	2.6	5.4	-2.3	0.9	2.2	-1.3	1.0	1.4
Leg fat percentage (left)	0.2	0.8	2.5	1.6	0.6	-0.3	0.2	-1.3	0.4
Arm fat-free mass (left)	0.5	2.5	6.5	-1.7	1.6	2.5	-1.2	0.4	1.1
Number of operations (self-reported)	0.6	0.9	3.1	1.5	0.3	-0.2	1.7	0.2	-0.5
Average weekly beer plus cider intake	0.6	0.8	2.4	0.1	-1.5	-1.5	-0.4	-0.5	0.3
Irritability	0.9	1.5	2.9	1.3	1.6	1.7	0.6	-0.8	-0.9
Risk taking	0.6	0.9	2.8	-0.8	-0.1	1.0	0.8	1.7	0.5
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.5	0.4	-1.3	-1.9	-0.2	-0.2	-0.2
Fractured/broken bones in last 5 years	0.4	0.5	1.1	0.5	0.4	1.1	-0.2	-0.8	-1.0
Age started oral contraceptive pill	0.6	0.8	1.6	0.5	0.2	1.0	-1.2	-1.3	-0.7
Diastolic blood pressure, automated reading	0.7	2.3	6.3	0.9	1.0	2.1	0.2	-1.0	2.5
Ever depressed for a whole week	1.0	1.2	4.3	1.3	0.3	0.4	0.8	-0.7	2.1
Unable to work because of sickness or disability	1.1	1.4	4.9	0.8	2.2	1.5	0.0	-0.5	-0.8
Commuting to job workplace: Cycle	0.2	0.2	0.6	0.0	0.3	-0.8	-0.4	-0.4	-0.5
Myopia	0.1	0.2	0.4	0.6	0.3	0.4	0.6	-0.3	0.4
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.4	-1.8	-0.9	-0.4	-1.3	0.4	1.3
Cholesterol lowering medication	0.6	0.9	2.0	1.1	1.2	0.7	0.3	-1.4	0.1
Medication: Omeprazole (e.g. Zanprol)	2.0	2.5	7.8	0.3	-2.8	-2.3	-0.8	-0.9	0.7
Pain experienced in last month	0.5	0.8	3.1	-0.3	-1.1	0.2	-0.5	0.3	-1.8
Supplements: Calcium	2.9	3.2	6.9	2.6	2.1	1.5	1.2	-2.1	-0.0
Basal cell carcinoma (self-reported)	0.6	0.8	2.0	-1.1	-1.4	-0.6	-0.3	0.6	-0.8
Heart attack/myocardial infarction (self-reported)	2.3	3.0	7.7	0.2	-0.8	-0.8	2.5	1.7	-2.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.6	-0.4	0.5	1.2	1.2	1.3	-0.2
Heart disease (siblings)	1.2	1.5	2.3	1.0	1.5	1.3	1.3	0.2	-1.5
Alcohol drinker status: Previous	0.8	0.9	2.0	1.4	1.2	-0.3	0.2	-1.2	0.4
Pack years of smoking	0.6	0.9	3.3	0.3	-0.0	0.1	1.8	1.4	-0.3
Impedance of whole body	1.2	6.3	14.9	1.5	-3.4	-3.9	0.0	-1.2	-2.8
Leg fat mass (left)	0.1	0.2	0.9	0.1	0.2	0.1	-0.4	-0.4	0.9
Arm predicted mass (left)	0.6	2.9	7.0	-1.9	1.7	2.6	-1.2	0.6	1.4