Hub : Genes

EML1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.068 0.025 8.8e-04 0.036 0.025 0.022 0.03 0.044 2.7e-05 0.00044 9.9e-04 0.00012 4.5e-06
2 GTEx Artery Aorta 0.367 0.085 3.5e-05 0.042 NA 0.090 NA 0.103 2.4e-03 NA 1.2e-05 NA 2.6e-06
3 GTEx Artery Tibial 0.144 0.042 3.0e-04 0.081 NA 0.091 NA 0.111 6.2e-07 NA 1.4e-07 NA 4.9e-09
4 GTEx Colon Sigmoid 0.257 0.084 4.4e-03 0.003 NA 0.002 NA 0.021 2.5e-01 NA 2.8e-01 NA 6.0e-02
5 GTEx Esophagus Mucosa 0.115 0.046 9.7e-03 0.022 NA 0.033 NA 0.033 1.2e-02 NA 2.9e-03 NA 2.6e-03
6 GTEx Testis 0.123 0.052 8.8e-03 0.046 NA 0.060 NA 0.049 4.3e-03 NA 1.2e-03 NA 3.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 1.7 2.6 6.9 0.9 1.9 0.3 2.6 1.8 -1.1
Bipolar Disorder or Schizophrenia 1.5 3.6 9.2 2.1 2.4 1.1 3.0 0.4 -0.8
Depressed Affect (Nagel 2018) 2.6 5.6 16.3 3.9 -0.0 -0.8 4.0 -0.2 -1.2
Depression (Nagel 2018) 1.2 1.8 6.7 1.9 0.3 0.3 2.6 0.1 0.3
Intelligence (Savage-Jansen 2018) 0.6 2.0 5.0 2.2 0.8 1.3 2.0 -0.7 0.2
Neuroticism (Nagel 2018) 1.3 3.2 9.5 2.8 -0.3 0.1 3.1 -0.2 -1.2
Schizophrenia (2018) 0.9 1.9 3.9 2.0 1.5 1.2 1.8 -0.9 -0.1
Schizophrenia vs Biploar Disorder 1.4 1.8 4.9 1.0 1.1 1.2 -1.4 -2.2 -0.6
Worry (Nagel 2018) 0.5 1.0 3.8 0.5 -0.5 0.2 2.0 1.2 -0.7
Alzheimer’s Disease (in mother) 0.4 0.5 1.1 1.1 0.1 -1.0 1.0 -0.2 -0.1
Alzheimer’s Disease (in father) 2.2 2.4 5.8 -0.5 -2.4 -1.8 1.4 1.5 1.0
Alzheimer’s Disease (including proxy) 1.0 1.4 3.1 0.1 -1.4 -1.8 1.4 1.2 0.5
Crohns Disease (2017) 0.1 0.3 0.7 0.6 0.6 -0.2 0.1 -0.6 -0.8
Irritable Bowel Disease (IBD) 0.4 0.9 2.6 1.6 0.6 0.8 1.0 -0.8 -0.4
Ulcerative Colitis (UC) 0.7 1.3 4.2 2.0 -0.3 0.5 1.7 -0.6 -0.1
Major Depression (MDD) 0.7 0.9 3.2 0.0 1.8 1.0 0.7 0.8 0.1
Reaction Time 0.3 0.6 1.4 1.2 0.1 -1.0 -0.0 -1.1 -0.1
Verbal and Numeric Reasoning (VNR) 0.9 2.1 7.0 2.7 -0.1 0.3 2.0 -1.1 0.4
Breast Cancer 0.2 0.6 1.5 0.6 1.2 -0.4 1.1 0.4 -0.5
Ovarian Cancer 0.4 0.5 2.2 0.0 1.5 -0.3 0.7 0.3 0.5
Prostate Cancer 0.2 0.3 0.7 -0.7 0.8 0.3 0.3 0.8 0.2
Age at First Birth 0.9 1.4 3.5 0.9 -0.7 -1.3 -0.6 -1.1 -1.9
Bipolar Disorder (2011) 2.8 2.7 5.7 -0.3 2.4 0.4 2.0 2.2 -1.2
Body Mass Index (BMI) (2010) 0.2 0.3 1.3 0.3 0.3 0.2 -0.3 -1.2 -0.2
Coronary Artery Disease (CAD) 4.0 4.7 17.0 0.6 2.0 2.6 0.8 -0.2 -4.1
Crohns Disease (2012) 0.3 0.6 2.4 0.7 -0.2 0.0 0.5 -0.3 -1.5
Mean Putamen Volume 1.2 1.3 3.3 -0.7 1.2 1.3 -1.8 -1.0 0.1
Fasting Glucose 0.9 1.0 2.2 1.5 -1.4 -0.7 0.6 -0.6 -1.0
HbA1C 0.9 0.9 3.4 -0.1 -1.8 -1.4 0.1 0.4 0.2
HDL Cholesterol 1.8 3.0 8.4 -2.9 -0.7 -0.6 -2.9 0.6 0.4
LDL Cholesterol 0.1 0.2 0.4 0.5 -0.5 0.4 -0.2 -0.6 -0.0
Lupus 2.2 3.4 8.5 -2.1 -1.9 -2.9 -0.8 0.8 1.6
Neuroticism (2016) 1.3 1.9 4.5 1.8 1.3 0.8 2.1 0.1 -1.2
Primary Biliary Cirrhosis 1.3 1.9 6.0 1.7 1.3 0.8 2.5 0.1 0.2
Rheumatoid Arthritis 0.5 0.7 2.7 -1.0 -0.6 -0.3 -1.6 -0.4 0.2
Schizophrenia (2014) 2.4 5.2 11.3 2.3 3.4 2.6 2.7 -0.2 -0.6
Triglycerides 1.1 1.7 6.3 1.8 -0.1 -0.7 2.5 0.7 -0.1
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.0 1.4 0.8 0.7 0.3 -1.3 -0.3
Ulcerative Colitis 1.4 2.1 5.2 2.3 0.7 1.7 0.9 -1.7 0.4
Blood Eosinophil Count 0.2 1.5 3.4 0.4 1.7 1.9 -0.7 -1.1 -0.7
Blood Platelet Count 0.1 1.3 4.0 0.6 -0.9 -2.0 0.1 -0.1 1.6
Blood Red Count 0.2 2.0 6.9 2.0 0.0 -0.1 2.6 0.1 -1.1
Blood White Count 0.2 1.2 4.8 -0.2 1.6 0.0 -0.0 0.1 2.2
Heel T-Score 0.5 4.2 12.8 -2.6 -0.2 -1.0 1.2 3.6 1.8
BMI 0.2 1.1 2.6 -1.0 1.2 0.3 -1.2 -0.3 1.6
Height 0.2 4.2 10.2 -3.2 -1.6 0.6 -3.1 0.6 -1.2
Waist Hip Ratio (WHR) 0.4 1.7 6.1 0.1 -1.8 -2.5 0.5 0.4 -0.6
Systolic Blood Pressure 3.1 15.7 44.7 2.0 5.5 6.7 1.5 -0.3 -3.5
Smoking Status 0.3 0.7 3.2 0.3 0.6 -0.4 0.3 0.2 1.8
Allergy or Eczema 0.1 0.2 0.4 -0.7 -0.5 0.1 -0.7 -0.1 -0.3
Cardiovascular Disease 0.3 1.1 2.5 1.6 1.1 1.1 0.7 -1.2 -0.1
Hypothyroidism (self reported) 0.2 0.5 1.8 -0.1 0.2 0.7 -0.1 -0.7 1.4
Respiratory disease 0.2 0.4 1.8 -0.7 -0.3 -1.3 -0.2 0.2 0.2
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.5 -0.8 -0.7 -1.2 0.2 0.8 -0.9
Lung FEV1/FVC ratio 0.9 4.5 10.3 -2.7 -3.2 -1.6 -2.6 0.0 -0.4
Lung FVC 0.5 2.7 7.9 -0.2 2.2 2.8 -1.1 -1.3 0.7
Neuroticism 1.0 2.4 8.4 2.3 -0.5 0.1 2.9 0.1 -0.7
Chronotype (morning person) 0.3 0.6 1.4 -0.6 0.7 0.7 -0.3 0.9 -1.2
Hair Pigment 0.1 2.2 7.2 -0.4 0.5 1.6 -2.7 -1.4 0.9
Tanning 0.2 3.0 11.7 -1.5 -1.5 -0.8 -3.4 -1.0 0.7
Hand grip strength (left) 0.7 1.8 3.1 -1.3 1.1 1.7 -1.4 0.4 -1.8
Number of treatments/medications taken 1.3 2.3 5.6 2.4 1.2 -0.2 2.4 -0.9 0.4
Average weekly spirits intake 0.6 0.8 2.1 1.4 0.4 0.6 -0.2 -1.4 0.3
Sensitivity / hurt feelings 1.2 2.0 7.6 1.1 -1.0 -0.8 2.8 1.4 0.2
Frequency of depressed mood in last 2 weeks 2.5 3.5 9.8 2.6 1.1 0.2 3.1 -0.2 -1.7
Hearing difficulty/problems: Yes 1.0 1.6 5.9 2.4 -0.1 -0.1 0.8 -1.6 0.4
Relative age of first facial hair 0.2 0.5 0.9 -0.8 0.5 -0.8 0.3 0.6 -0.9
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.0 0.2 1.4 1.4 -0.1 -0.6 0.6
Ever used hormone-replacement therapy (HRT) 1.3 1.6 3.9 0.6 -1.5 -1.2 -1.2 -2.0 0.7
Ever had hysterectomy (womb removed) 1.0 1.1 3.4 0.9 1.8 1.0 0.8 0.1 0.8
Systolic blood pressure, automated reading 4.0 11.6 36.0 2.1 4.9 6.0 1.1 -1.0 -1.7
Eye problems/disorders: Diabetes related eye disease 0.1 0.2 0.6 -0.1 -0.1 -0.8 -0.3 -0.5 0.1
Angina 1.5 2.0 7.1 0.8 -0.2 -0.2 1.9 0.6 -2.7
Medication for hormone replacement therapy 1.0 1.2 2.7 -1.6 -0.6 -1.0 0.6 1.6 0.2
Vitamin and mineral supplements 0.6 0.8 2.0 0.3 -0.3 0.9 -1.3 -1.4 -0.1
Supplements: Zinc 1.4 1.5 4.3 2.1 1.2 0.6 0.8 -1.3 -0.5
Medication: Co-codamol 0.4 0.5 1.6 0.1 0.9 1.3 0.4 0.1 -0.4
Medication: Metformin 0.2 0.3 1.2 -0.1 -0.5 -0.3 0.4 0.3 -1.1
Diabetes (father) 0.7 0.9 3.0 -1.0 0.6 0.7 0.8 1.7 0.2
Diabetes (mother) 0.7 0.9 3.6 -0.9 -0.6 -0.5 -0.2 0.7 1.9
Severe depression (siblings) 1.0 1.1 5.3 -0.2 -0.4 -0.8 0.8 0.5 2.3
Pack years adult smoking proportion 0.5 0.7 2.3 -0.3 -0.0 -0.1 1.4 1.5 -0.4
Impedance of leg (right) 1.3 6.2 10.9 2.5 -2.7 -3.2 0.9 -1.3 -3.3
Leg fat-free mass (left) 0.7 3.5 9.1 -3.0 0.6 2.1 -1.6 1.3 1.7
Trunk fat percentage 0.2 0.7 1.4 0.1 -0.9 -1.2 -0.8 -0.8 0.9
Hand grip strength (right) 0.9 2.5 7.1 -0.9 2.1 2.7 -1.5 -0.4 -0.8
Townsend deprivation index at recruitment 1.0 1.4 6.1 0.9 2.5 0.1 1.1 -0.3 -0.1
Current tobacco smoking 0.5 0.9 1.9 1.4 0.7 0.4 0.8 -0.6 1.3
Average weekly fortified wine intake 0.7 0.9 2.1 0.0 0.6 0.9 1.2 1.4 0.6
Maternal smoking around birth 1.2 1.7 5.1 2.3 -0.6 -0.7 1.5 -1.0 -1.0
Fed-up feelings 2.1 3.8 10.8 3.3 0.3 -0.3 3.0 -0.8 -1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.9 2.5 5.6 2.3 2.0 0.6 2.4 -0.4 0.1
Relative age voice broke 0.5 0.8 2.8 -1.7 0.3 -0.9 -0.8 0.7 -0.0
Taking other prescription medications 0.6 1.0 3.1 0.4 1.2 0.2 1.1 -0.1 1.8
Age when periods started (menarche) 0.2 0.5 1.1 0.0 0.3 -0.2 1.1 0.9 -0.7
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.8 -0.4 -0.4 -0.4 -0.3 0.2 1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.7 -0.4 -0.3 -0.9 0.4 0.3 -0.1
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 1.7 0.4 -0.3 -0.2 1.3 0.9 0.3
Qualifications: CSEs or equivalent 0.7 0.9 3.1 -0.1 -0.7 -1.8 1.0 1.1 -0.1
Serious illness, injury or assault to yourself 1.2 1.4 4.0 -1.5 0.6 0.2 0.8 2.0 1.1
High blood pressure 0.3 0.9 3.0 1.7 0.9 0.3 0.8 -0.7 -0.2
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.5 -0.7 0.4 0.6 -0.6 -0.1 0.2
Multivitamins +/- minerals 0.9 1.2 4.2 -0.4 -1.4 -2.0 0.6 0.7 0.6
Stomach or abdominal pain in last month 0.5 0.6 2.1 0.5 0.4 -0.2 -1.1 -1.5 0.2
Supplements: Glucosamine 0.3 0.4 1.1 0.4 -0.7 -0.2 1.0 0.1 1.0
Diverticular disease/diverticulitis (self-reported) 2.8 3.4 11.8 2.1 -0.7 0.4 -1.4 -3.4 1.2
Medication: Atenolol 0.3 0.4 1.1 0.2 -0.8 -1.0 0.7 0.5 -0.3
Medication: Levothyroxine sodium 0.6 1.1 4.3 0.8 -0.3 0.6 -0.1 -1.0 2.1
Sitting height 0.3 1.9 3.8 -1.9 -0.5 1.7 0.1 1.6 -1.3
Chronic bronchitis/emphysema (father) 0.6 0.7 2.7 0.0 -0.2 -0.6 0.8 0.6 -1.6
High blood pressure (mother) 0.0 0.0 0.1 0.2 -0.3 0.3 0.1 -0.1 0.1
Body mass index (BMI) 0.2 1.0 3.3 -0.5 1.1 0.8 -0.6 -0.1 1.8
Impedance of leg (left) 1.2 5.7 9.5 2.6 -2.3 -3.0 0.7 -1.8 -3.1
Leg predicted mass (left) 0.6 3.3 8.8 -3.0 0.5 2.0 -1.6 1.3 1.7
Trunk fat mass 0.1 0.5 1.3 -0.5 -0.5 -0.4 -0.9 -0.3 1.1
Waist circumference 0.1 0.4 1.7 -0.2 -0.3 -0.7 -0.1 0.0 1.3
Number of incorrect matches in round 0.8 1.3 3.1 1.1 -0.3 -0.6 -0.6 -1.8 -1.7
Past tobacco smoking 0.2 0.3 0.8 0.7 -0.2 0.3 0.8 0.0 -0.9
Alcohol usually taken with meals 1.1 1.9 5.4 -2.2 0.0 0.7 -0.3 2.3 0.4
Nervous feelings 0.6 1.2 3.1 0.1 -0.2 -0.5 1.8 1.5 -1.2
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 2.7 0.2 0.7 -0.1 1.6 0.9 0.6
Hearing difficulty/problems with background noise 2.0 3.2 9.6 3.1 -0.8 -0.9 0.5 -2.8 -0.3
Hair/balding pattern: Pattern 2 0.8 1.1 2.3 -0.6 0.0 -0.2 1.1 1.5 1.5
Had menopause 0.5 0.7 2.6 1.0 -0.1 0.3 -0.5 -1.6 0.4
Had other major operations 0.2 0.3 0.8 0.2 -0.5 -0.1 0.9 0.8 -0.0
Forced vital capacity (FVC) 0.2 0.9 2.5 -1.5 -0.0 0.8 -1.6 0.0 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.8 -0.5 0.4 -0.5 1.3 1.1 0.2
Ever unenthusiastic/disinterested for a whole week 0.9 1.0 2.6 1.6 0.2 -0.1 1.3 -0.4 1.3
Qualifications: None of the above 0.4 0.9 2.1 1.4 0.2 -0.8 1.1 -0.5 -1.0
Financial difficulties in last 2 years 1.7 2.2 5.3 2.3 1.5 0.1 1.9 -0.9 -1.1
Mouth/teeth dental problems 0.7 1.0 4.1 -1.1 -0.4 0.3 -2.0 -0.8 0.3
Heart attack 2.5 3.2 9.5 0.5 -0.6 -0.4 2.6 1.6 -3.1
Allergy 0.1 0.2 0.6 0.2 -0.8 -0.4 -0.1 0.1 0.4
Pain all over the body in last month 0.2 0.2 0.4 0.4 0.4 -0.6 -0.0 -0.4 -0.5
Diabetes (self-reported) 0.5 0.7 2.7 0.6 -0.6 -0.6 0.2 -0.9 -1.6
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 2.0 -1.3 1.4 0.7 -0.3 1.0 1.1
Medication: Ramipril 0.6 0.8 2.7 0.5 0.6 -0.4 1.0 0.6 -1.6
Medication: Simvastatin 0.5 0.8 2.4 1.5 -0.0 0.4 1.1 -0.9 0.1
Fluid intelligence score 0.6 1.3 3.7 1.9 -0.3 0.5 1.7 -0.2 0.8
Illnesses of siblings 1.1 1.6 6.2 0.8 -0.7 -0.7 -1.3 -2.5 0.2
Neuroticism score 1.2 2.6 9.1 2.4 0.2 -0.1 3.0 -0.0 -0.7
Weight 0.2 1.0 1.7 -1.3 0.5 1.2 -1.0 0.4 1.2
Impedance of arm (right) 1.6 7.3 19.4 0.5 -4.1 -4.4 -0.5 -0.6 -2.6
Arm fat percentage (right) 0.2 0.7 2.1 0.1 -0.6 -1.4 -0.8 -0.5 0.8
Trunk fat-free mass 0.4 2.5 6.9 -2.0 1.1 2.6 -1.0 0.9 1.1
Hip circumference 0.1 0.5 1.7 -0.7 -0.0 0.4 -0.8 0.1 1.3
Time employed in main current job 1.1 1.3 4.3 -0.8 0.8 1.2 -2.1 -0.8 -0.2
Alcohol intake versus 10 years previously 1.2 1.8 5.5 1.3 -0.6 -0.6 2.3 0.8 -1.5
Father’s age at death 0.2 0.3 0.7 -0.2 -0.4 0.3 -0.7 -0.5 0.8
Worrier / anxious feelings 0.3 0.6 1.6 0.7 -0.6 -1.3 1.2 -0.2 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 3.2 1.8 0.5 -0.0 1.4 -0.9 -0.6
Falls in the last year 0.8 1.1 2.3 -1.4 -0.4 -1.0 0.1 1.1 1.5
Hair/balding pattern: Pattern 3 1.1 1.7 5.6 1.6 0.3 0.0 -0.8 -2.4 -1.0
Number of live births 0.9 1.2 3.8 1.3 -0.8 -1.0 -0.6 -1.9 -0.2
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 5.2 -2.3 -0.4 0.6 -2.3 -0.1 -0.0
Pulse rate 0.6 1.0 1.8 1.4 1.1 -0.3 1.1 -0.8 1.0
Happiness 2.3 2.8 9.2 3.0 1.4 0.3 1.2 -1.9 0.8
Noisy workplace 0.3 0.3 1.4 0.5 -0.1 -0.2 1.2 -0.0 -0.5
Qualifications: A levels/AS levels or equivalent 0.5 1.2 3.8 -0.4 -0.2 0.8 1.6 1.9 -0.2
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.2 1.1 0.5 0.1 0.3 -0.7 -0.8
Mouth/teeth dental problems: Dentures 0.2 0.4 0.9 0.7 0.4 0.6 0.9 0.3 0.5
Asthma 0.2 0.4 1.7 -0.4 0.2 -1.3 0.2 0.2 -0.5
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.3 4.8 -1.8 1.5 -0.0 1.4 2.2 1.3
Medication: Cholesterol lowering 1.2 1.9 6.2 2.5 0.3 0.3 0.8 -1.6 -1.4
Depression (self-reported) 3.7 4.5 9.7 1.4 3.1 2.9 2.5 0.6 0.2
Medication: Lansoprazole 1.0 1.1 3.0 0.7 -1.1 -0.8 -0.8 -1.7 0.9
Prospective memory result 0.5 0.6 1.4 -1.2 -0.5 1.0 -0.9 0.4 -0.5
Lung cancer (father) 0.2 0.2 1.1 0.0 -0.2 -1.0 -0.1 -0.3 0.1
Illnesses of mother 1.0 1.3 3.1 -1.0 1.8 0.8 -1.2 0.2 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 6.0 -2.0 0.4 2.4 -1.9 -0.2 -0.0
Pulse wave Arterial Stiffness index 0.6 0.7 2.4 0.8 0.5 0.3 1.6 0.6 -0.5
Impedance of arm (left) 1.2 5.6 15.6 0.3 -3.8 -4.0 -0.4 -0.4 -1.8
Arm fat mass (right) 0.2 0.6 2.1 -0.7 0.0 -0.3 -1.0 -0.2 1.5
Trunk predicted mass 0.5 2.6 7.1 -2.0 1.2 2.7 -1.0 0.9 1.0
Standing height 0.2 1.9 4.7 -2.2 -1.6 0.9 -1.4 0.8 -0.7
Length of working week for main job 0.4 0.5 0.9 -0.7 -0.7 -0.9 0.3 0.8 -0.2
Exposure to tobacco smoke at home 0.9 1.0 2.4 0.8 -0.1 -1.4 0.9 0.4 -1.6
Breastfed as a baby 0.3 0.4 1.0 -0.6 1.0 0.3 -0.7 0.2 -0.8
Tense / ‘highly strung’ 1.2 1.9 5.5 1.0 1.8 0.5 2.4 1.0 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.6 2.4 4.0 1.3 1.6 1.4 2.0 -0.2 2.0
Hair/balding pattern: Pattern 4 0.6 1.6 3.7 -1.9 -1.4 0.2 -1.3 1.0 1.0
Birth weight of first child 0.5 1.0 3.8 -0.8 -0.4 -0.6 0.9 1.9 0.4
Peak expiratory flow (PEF) 0.9 2.0 7.4 -1.6 -0.7 -0.1 -2.7 -1.0 -0.7
Pulse wave reflection index 1.1 1.3 3.4 -0.8 -1.8 -0.7 0.4 1.8 0.1
Ever highly irritable/argumentative for 2 days 1.3 1.6 3.0 1.2 1.5 1.7 -0.2 -1.3 -1.1
Loud music exposure frequency 0.3 0.3 1.5 -0.1 0.0 -0.3 0.7 -0.1 1.2
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.3 0.4 -0.8 0.9 -0.5 -1.1 0.6
Mouth/teeth dental problems: Bleeding gums 2.0 2.6 7.3 0.8 0.4 -0.5 2.7 1.6 -2.1
Blood clot in the leg (DVT) 0.9 1.1 3.1 -0.8 0.5 1.1 1.3 1.8 -0.1
Medication: Paracetamol 4.2 7.0 13.1 -2.6 -2.3 -3.6 0.1 2.3 3.5
Headache pain in last month 1.1 1.9 8.0 -0.1 0.2 -1.6 0.8 0.5 2.8
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 3.4 -1.8 0.5 0.9 -1.6 0.2 1.2
Glaucoma (self-reported) 0.7 0.8 2.2 0.7 -0.6 0.0 -0.5 -1.3 -1.5
Gout (self-reported) 0.8 1.1 2.5 -0.5 -1.3 -1.6 0.1 0.3 1.5
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 4.6 0.5 -0.4 0.4 -0.6 -1.5 2.1
Medication: Amlodipine 0.9 1.2 3.2 1.3 1.1 1.1 0.2 -1.8 -0.1
Medication: Ventolin 100micrograms inhaler 1.1 1.5 4.4 -1.3 -0.0 -0.8 0.7 2.1 -1.3
Birth weight 0.8 1.8 3.2 -1.8 -1.7 -1.0 -0.9 1.2 1.0
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.8 0.5 -1.2 -1.1 0.9 0.1 -1.3
High blood pressure (siblings) 0.9 1.3 4.3 -1.3 0.7 0.7 0.7 2.1 0.7
Forced vital capacity (FVC), Best measure 0.5 1.7 6.6 -1.1 0.7 2.6 -1.3 -0.4 -0.0
Body fat percentage 0.2 0.6 1.6 0.4 -0.8 -1.3 -0.6 -0.8 0.6
Leg fat percentage (right) 0.1 0.5 1.9 1.4 0.3 -0.6 0.4 -0.8 0.2
Arm fat-free mass (right) 0.6 3.2 8.7 -1.9 1.8 2.9 -1.1 0.6 1.5
Exposure to tobacco smoke outside home 0.6 0.8 1.7 1.2 -0.5 -0.3 0.6 -0.9 -1.3
Comparative body size at age 10 0.4 1.2 3.4 -1.5 0.3 0.4 -1.8 0.3 1.1
Number of full brothers 1.5 1.9 6.1 -1.2 -0.2 -1.1 1.3 2.5 -0.7
Worry too long after embarrassment 0.5 0.9 2.5 1.6 0.2 1.0 0.3 -1.3 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.6 4.1 1.0 1.9 2.0 0.4 -0.8 0.7
Wheeze or whistling in the chest in last year 0.4 0.7 2.7 0.2 1.6 -0.5 1.0 0.2 -0.5
Number of children fathered 1.0 1.2 4.2 0.2 -0.4 -0.2 1.3 1.0 2.0
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.0 0.6 -1.4 -0.6 -1.0 -1.1 -0.0
Age at first live birth 0.5 0.9 2.8 -0.1 -1.2 -0.2 -1.7 -0.8 0.4
Pulse wave peak to peak time 0.7 0.8 2.8 -0.8 -0.6 -0.3 -1.7 -0.7 0.7
Health satisfaction 0.5 0.6 1.3 1.1 0.2 -0.6 0.7 -0.8 0.9
Shortness of breath walking on level ground 0.3 0.3 1.6 0.1 1.3 0.5 0.1 -0.1 0.0
Qualifications: College or University degree 0.6 2.0 3.6 -1.8 0.7 1.2 -0.6 1.9 1.7
Eye problems/disorders: None of the above 3.3 3.8 12.8 -2.9 -0.1 -0.8 0.8 3.6 0.4
Mouth/teeth dental problems: Loose teeth 2.6 3.1 9.3 -2.8 0.1 0.1 -3.0 0.4 1.2
Emphysema/chronic bronchitis 0.4 0.4 1.2 0.8 0.7 0.3 1.1 0.2 0.1
Medication for pain relief, constipation, heartburn 1.9 3.2 8.0 0.5 1.7 2.7 -0.9 -0.5 -2.8
Neck or shoulder pain in last month 0.1 0.2 0.3 0.4 0.5 -0.3 0.5 -0.5 -0.1
Medication: Blood pressure 0.7 1.3 2.8 1.6 -0.3 -1.0 1.7 0.0 -1.1
Angina (self-reported) 1.7 2.3 7.7 1.1 -0.3 -0.3 2.1 0.4 -2.8
Migraine (self-reported) 2.0 2.5 11.7 -0.7 -0.4 -0.5 1.1 1.1 3.4
Medication: Ibuprofen 1.5 1.8 3.7 -1.3 1.5 -0.1 1.6 1.9 0.6
Medication: Allopurinol 0.5 0.6 2.5 -0.7 -0.6 -0.6 -0.1 0.2 1.6
Medication: Omeprazole 1.5 1.7 5.2 -0.0 -2.3 -2.1 0.0 0.0 0.8
Medication: Seretide 50 evohaler 2.0 2.3 5.8 -1.3 1.2 0.1 -2.4 -1.1 2.0
Mean time to correctly identify matches 0.9 1.7 4.7 2.2 1.0 -0.2 0.0 -2.1 -0.2
Heart disease (mother) 2.2 2.6 4.7 2.2 -0.5 -1.5 1.6 -1.2 -2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 3.4 0.4 1.9 0.2 1.2 0.9 -0.4
Whole body fat mass 0.1 0.3 0.8 -0.3 -0.3 -0.4 -0.8 -0.4 0.9
Leg fat mass (right) 0.0 0.1 0.6 -0.0 0.1 0.1 -0.4 -0.2 0.8
Arm predicted mass (right) 0.6 3.3 8.2 -1.9 1.8 2.9 -0.8 0.8 1.8
Pulse rate, automated reading 0.2 0.7 1.2 1.1 0.9 1.1 0.3 -0.9 0.5
Alcohol intake frequency. 1.6 3.8 11.5 2.5 1.8 0.5 3.4 -0.4 -1.2
Comparative height size at age 10 0.3 1.7 5.2 -1.7 -1.3 0.2 -2.3 -0.1 0.4
Number of full sisters 0.9 1.1 2.6 1.4 0.6 -1.0 0.6 -0.6 -1.6
Suffer from ‘nerves’ 0.8 1.3 4.4 -0.2 -0.4 -1.0 2.1 1.4 -0.6
Overall health rating 0.4 0.8 3.1 0.0 1.0 -0.8 0.0 -0.6 1.8
Chest pain or discomfort 1.6 2.2 4.5 2.1 1.3 -0.0 2.1 -0.4 -1.6
Had major operations 2.0 2.4 5.5 1.5 0.8 1.6 2.3 0.4 -1.8
Age at last live birth 0.4 0.5 1.6 -0.0 -1.3 -0.3 -0.5 -0.1 -1.1
Family relationship satisfaction 1.5 1.8 6.1 0.5 2.5 1.5 0.9 0.1 1.2
Leg pain on walking 0.7 0.9 2.0 1.4 0.6 1.1 1.3 -0.5 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.2 -0.3 -0.1 0.5 1.5 1.5 0.6
Commuting to job workplace: Car/motor vehicle 0.5 0.6 0.9 0.9 -0.5 0.6 -0.0 -1.0 -1.0
Illness, injury, bereavement, stress in last 2 years 1.4 1.8 4.6 -1.5 -1.8 -0.7 -2.1 -0.3 0.1
Medication: Aspirin 1.4 1.8 5.7 1.2 -0.8 -1.3 2.4 0.6 -1.1
Supplements: Vitamin C 1.2 1.4 4.3 -0.4 2.1 1.8 0.6 0.5 -0.3
Knee pain experienced in last month 0.5 0.9 2.8 -0.2 0.5 -0.2 1.2 0.8 1.7
Hypertension (Self-reported) 0.4 1.2 3.6 1.9 1.2 0.9 1.0 -0.7 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 3.5 1.9 0.1 -0.3 1.1 -1.2 1.2
Illnesses of father: Heart disease 3.0 4.1 8.6 1.4 2.0 2.9 2.4 0.5 -2.0
Illnesses of siblings: Diabetes 2.1 2.6 7.5 0.1 1.0 -0.2 2.7 2.6 0.0
Smoking status: Previous 0.1 0.1 0.3 -0.2 0.3 -0.0 -0.5 -0.4 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 4.8 -2.2 -0.4 -0.1 -2.2 0.3 0.2
Whole body fat-free mass 0.5 3.0 6.3 -2.4 1.1 2.5 -1.3 1.0 1.4
Leg fat-free mass (right) 0.7 4.0 10.7 -3.3 0.8 2.1 -1.6 1.4 1.8
Arm fat percentage (left) 0.2 0.7 1.9 -0.1 -0.6 -1.4 -0.6 -0.2 1.3
Average weekly red wine intake 1.7 2.4 8.6 -2.2 -0.5 0.1 -2.9 -0.1 -0.9
Handedness (chirality/laterality): Left-handed 1.2 1.4 3.9 0.4 0.2 -0.9 2.0 1.4 -1.3
Mood swings 1.9 3.4 9.9 2.9 0.7 -0.2 3.1 -0.3 -1.1
Loneliness, isolation 3.3 4.6 17.4 2.3 0.9 0.0 4.2 0.9 -1.8
Long-standing illness, disability or infirmity 0.8 1.1 3.4 0.4 1.8 1.4 -0.1 -0.8 0.8
Ever had bowel cancer screening 1.2 1.4 3.1 1.8 1.5 0.8 1.4 -0.7 0.4
Diabetes diagnosed by doctor 0.2 0.3 1.5 0.1 -0.3 -0.2 0.2 -0.4 -1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.7 0.7 0.3 -0.8 0.7 -0.3 -0.8
Friendships satisfaction 1.0 1.3 4.9 0.5 0.2 -0.6 2.2 1.5 0.0
Qualifications: nursing, teaching 0.4 0.7 1.5 0.0 0.9 0.5 -0.9 -0.9 1.2
Commuting to job workplace: Walk 0.5 0.5 1.2 -1.0 1.1 -0.2 0.6 0.6 -0.1
Eye problems/disorders: Cataract 2.0 2.3 7.7 2.8 0.8 0.9 0.4 -2.1 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 1.0 1.0 0.1 -0.5 1.0 -0.2 -0.2
Medication for cholesterol 0.3 0.5 1.1 0.8 -1.0 -0.4 0.4 -0.2 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.5 1.0 -0.6 -0.3 -0.5 -1.6 0.8
Back pain experienced in last month 1.0 1.4 4.0 0.7 1.8 2.0 0.2 -0.9 -0.0
Mineral and other dietary supplements 0.4 0.6 1.5 -0.2 -0.2 -0.9 0.6 1.2 -0.8
Breast cancer (self-reported) 0.3 0.4 1.1 -0.1 0.1 -1.0 -0.8 -0.8 -0.3
Asthma (self-reported) 0.2 0.4 1.3 -0.4 0.2 -1.1 0.0 0.1 -0.8
Osteoporosis (self-reported) 0.8 1.0 2.7 0.9 1.3 1.6 -0.3 -0.8 -0.4
Osteoarthritis (self-reported) 1.8 2.4 4.6 -0.6 -1.9 -2.1 0.8 1.3 1.8
Medication: Aspirin 1.3 1.7 5.4 1.4 -0.5 -1.0 2.3 0.4 -1.3
Medication: Gliclazide 0.9 1.0 2.9 -0.8 0.8 0.6 1.1 1.7 -0.3
Illnesses of father: None of the above (group 1) 2.8 3.5 9.6 -0.6 -1.9 -3.1 -1.7 -1.2 1.7
Smoking status: Current 0.4 0.7 3.1 0.8 -0.1 -0.4 0.3 -0.4 1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 2.0 -1.2 0.1 1.4 -0.7 -0.2 0.4
Whole body water mass 0.5 3.1 6.9 -2.3 1.3 2.6 -1.2 0.9 1.5
Leg predicted mass (right) 0.7 4.0 10.5 -3.2 0.8 2.1 -1.7 1.3 1.9
Arm fat mass (left) 0.2 0.8 3.0 -0.9 -0.0 -0.3 -1.0 0.0 1.7
Number of self-reported non-cancer illnesses 1.7 2.9 4.9 2.1 1.7 1.2 2.2 -0.6 1.8
Average weekly champagne plus white wine intake 3.4 4.7 10.1 -3.0 0.4 -0.6 -0.1 3.2 2.9
Miserableness 2.3 4.0 11.7 3.4 0.0 -1.0 3.3 -0.4 0.5
Guilty feelings 0.5 0.8 2.4 1.5 -0.2 0.4 1.4 -0.4 -0.5
Wears glasses or contact lenses 0.9 1.1 2.6 1.2 0.1 -0.5 1.1 -0.8 1.6
Ever taken oral contraceptive pill 0.2 0.3 0.6 -0.4 0.6 0.1 -0.7 -0.5 -0.5
Hearing aid user 1.0 1.2 2.5 1.1 -0.5 -0.4 -1.1 -1.6 1.2
Mother’s age at death 0.1 0.1 0.2 -0.3 -0.2 0.4 -0.2 0.3 -0.3
Financial situation satisfaction 0.7 0.8 2.8 0.8 0.6 -0.2 1.1 -0.1 1.7
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.4 0.9 0.4 -0.3 1.5 0.4 1.2
Commuting to job workplace: Public transport 0.4 0.5 1.5 -0.5 -0.3 -0.8 -0.1 0.5 1.2
Eye problems/disorders: Glaucoma 1.0 1.2 4.0 0.9 -0.3 -0.1 -0.9 -2.0 -1.3
Medication: Blood pressure 0.4 0.8 2.4 0.2 1.6 1.5 0.1 0.0 0.1
Pain type(s) experienced in last month: Hip pain 1.2 1.5 7.1 0.2 2.7 1.2 0.5 0.1 0.5
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.9 -0.3 0.3 1.4 -0.7 -0.5 0.9
High cholesterol (Self-reported) 1.3 2.3 6.5 2.4 0.8 0.7 -0.2 -2.6 -0.7
Medication: Bendroflumethiazide 1.7 2.6 7.2 2.7 1.3 0.7 1.6 -0.8 -1.8
Medication: Paracetamol 3.8 5.9 11.6 -2.5 -2.4 -3.4 0.4 2.2 2.6
Medication: Lisinopril 2.6 3.4 6.5 1.7 1.8 1.6 2.2 0.4 -2.5
Medication: Atorvastatin 0.8 1.0 4.5 0.8 2.1 0.7 0.2 -0.4 -0.3
Illnesses of father: High blood pressure 0.7 0.8 3.0 -0.2 1.7 1.0 0.3 0.8 -0.5
Alcohol drinker status: Never 1.5 1.8 6.8 0.5 -1.1 -2.6 -0.1 -0.7 1.4
Ever smoked 0.3 0.5 1.7 -0.7 0.1 -0.4 -0.7 0.0 1.3
Basal metabolic rate 0.5 2.6 5.4 -2.3 0.9 2.2 -1.3 1.0 1.4
Leg fat percentage (left) 0.2 0.8 2.5 1.6 0.6 -0.3 0.2 -1.3 0.4
Arm fat-free mass (left) 0.5 2.5 6.5 -1.7 1.6 2.5 -1.2 0.4 1.1
Number of operations (self-reported) 0.6 0.9 3.1 1.5 0.3 -0.2 1.7 0.2 -0.5
Average weekly beer plus cider intake 0.6 0.8 2.4 0.1 -1.5 -1.5 -0.4 -0.5 0.3
Irritability 0.9 1.5 2.9 1.3 1.6 1.7 0.6 -0.8 -0.9
Risk taking 0.6 0.9 2.8 -0.8 -0.1 1.0 0.8 1.7 0.5
Ever had prostate specific antigen (PSA) test 0.8 0.9 3.5 0.4 -1.3 -1.9 -0.2 -0.2 -0.2
Fractured/broken bones in last 5 years 0.4 0.5 1.1 0.5 0.4 1.1 -0.2 -0.8 -1.0
Age started oral contraceptive pill 0.6 0.8 1.6 0.5 0.2 1.0 -1.2 -1.3 -0.7
Diastolic blood pressure, automated reading 0.7 2.3 6.3 0.9 1.0 2.1 0.2 -1.0 2.5
Ever depressed for a whole week 1.0 1.2 4.3 1.3 0.3 0.4 0.8 -0.7 2.1
Unable to work because of sickness or disability 1.1 1.4 4.9 0.8 2.2 1.5 0.0 -0.5 -0.8
Commuting to job workplace: Cycle 0.2 0.2 0.6 0.0 0.3 -0.8 -0.4 -0.4 -0.5
Myopia 0.1 0.2 0.4 0.6 0.3 0.4 0.6 -0.3 0.4
Vascular/heart problems diagnosed by doctor 0.5 1.3 3.4 -1.8 -0.9 -0.4 -1.3 0.4 1.3
Cholesterol lowering medication 0.6 0.9 2.0 1.1 1.2 0.7 0.3 -1.4 0.1
Medication: Omeprazole (e.g. Zanprol) 2.0 2.5 7.8 0.3 -2.8 -2.3 -0.8 -0.9 0.7
Pain experienced in last month 0.5 0.8 3.1 -0.3 -1.1 0.2 -0.5 0.3 -1.8
Supplements: Calcium 2.9 3.2 6.9 2.6 2.1 1.5 1.2 -2.1 -0.0
Basal cell carcinoma (self-reported) 0.6 0.8 2.0 -1.1 -1.4 -0.6 -0.3 0.6 -0.8
Heart attack/myocardial infarction (self-reported) 2.3 3.0 7.7 0.2 -0.8 -0.8 2.5 1.7 -2.8
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.6 -0.4 0.5 1.2 1.2 1.3 -0.2
Heart disease (siblings) 1.2 1.5 2.3 1.0 1.5 1.3 1.3 0.2 -1.5
Alcohol drinker status: Previous 0.8 0.9 2.0 1.4 1.2 -0.3 0.2 -1.2 0.4
Pack years of smoking 0.6 0.9 3.3 0.3 -0.0 0.1 1.8 1.4 -0.3
Impedance of whole body 1.2 6.3 14.9 1.5 -3.4 -3.9 0.0 -1.2 -2.8
Leg fat mass (left) 0.1 0.2 0.9 0.1 0.2 0.1 -0.4 -0.4 0.9
Arm predicted mass (left) 0.6 2.9 7.0 -1.9 1.7 2.6 -1.2 0.6 1.4