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chr15:39,530,508-42,957,373

Best TWAS P=7.24e-20 · Best GWAS P=8.16e-19 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	EXD1	0.04	0.04	lasso	3	0.04	8.1e-06	7.75	-7.2	7.5e-13	-0.05	0.03	0.97	TRUE
2	CommonMind	Brain Pre-frontal Cortex	JMJD7	0.10	0.06	bslmm	419	0.07	2.4e-09	6.85	5.3	1.1e-07	0.03	0.02	0.98	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MAPKBP1	0.10	0.06	enet	15	0.10	9.6e-13	6.72	-5.5	4.1e-08	-0.03	0.05	0.95	FALSE
4	CommonMind	Brain Pre-frontal Cortex	SRP14	0.18	0.04	lasso	7	0.07	5.0e-09	2.23	-5.7	1.3e-08	0.59	0.11	0.88	FALSE
5	GTEx	Adipose Subcutaneous	EIF2AK4	0.38	0.08	enet	18	0.23	4.7e-19	-7.28	-6.0	2.2e-09	0.60	0.62	0.38	FALSE
6	GTEx	Adipose Visceral Omentum	EIF2AK4	0.23	0.08	lasso	7	0.15	2.7e-08	-8.86	-7.8	8.7e-15	0.79	0.00	0.99	FALSE
7	GTEx	Adipose Visceral Omentum	SRP14	0.36	0.07	lasso	7	0.16	9.5e-09	-1.23	-5.7	1.5e-08	0.66	0.06	0.94	FALSE
8	GTEx	Artery Aorta	PLA2G4B	0.10	0.02	lasso	3	0.02	3.9e-02	6.63	6.7	1.9e-11	0.01	0.02	0.85	FALSE
9	GTEx	Artery Aorta	OIP5-AS1	0.16	0.21	enet	26	0.23	5.2e-13	5.17	5.9	3.3e-09	-0.01	1.00	0.00	TRUE
10	GTEx	Artery Tibial	EHD4	0.14	0.03	enet	21	0.06	1.0e-05	2.02	-5.7	9.7e-09	-0.04	0.19	0.76	FALSE
11	GTEx	Artery Tibial	MAPKBP1	0.07	0.01	lasso	6	0.00	4.3e-01	-5.55	-5.9	3.5e-09	-0.02	0.04	0.91	FALSE
12	GTEx	Brain Cerebellum	MAPKBP1	0.23	0.09	lasso	8	0.12	2.2e-04	6.67	-7.8	8.8e-15	-0.03	0.01	0.97	FALSE
13	GTEx	Brain Cerebellum	SRP14	0.26	0.00	enet	8	0.04	2.3e-02	-8.80	-6.9	5.8e-12	0.77	0.01	0.80	FALSE
14	GTEx	Brain Cerebellum	RP11-23P13.4	0.19	0.05	enet	13	0.10	7.6e-04	6.67	-7.3	2.3e-13	-0.02	0.02	0.88	FALSE
15	GTEx	Brain Cortex	MAPKBP1	0.29	0.00	enet	21	0.04	2.7e-02	-5.64	-6.3	3.6e-10	0.00	0.04	0.80	FALSE
16	GTEx	Brain Cortex	GCHFR	0.25	0.04	enet	15	0.05	1.4e-02	7.81	-8.0	1.4e-15	-0.04	0.03	0.77	TRUE
17	GTEx	Brain Hippocampus	ZFYVE19	0.20	0.07	lasso	8	0.01	2.0e-01	4.27	-5.8	8.5e-09	0.03	0.07	0.06	FALSE
18	GTEx	Breast Mammary Tissue	EIF2AK4	0.24	0.10	lasso	8	0.06	3.2e-04	-8.86	-8.6	6.8e-18	0.97	0.00	1.00	FALSE
19	GTEx	Breast Mammary Tissue	OIP5-AS1	0.20	0.24	lasso	7	0.22	1.8e-11	5.62	5.7	1.3e-08	-0.01	1.00	0.00	FALSE
20	GTEx	Breast Mammary Tissue (Male)	RP11-111A22.1	0.39	0.22	enet	40	0.29	1.6e-07	4.65	6.2	4.4e-10	-0.04	0.82	0.02	FALSE
21	GTEx	Breast Mammary Tissue (Female)	OIP5-AS1	0.28	0.31	lasso	3	0.29	3.0e-09	5.62	6.2	5.7e-10	-0.01	0.74	0.24	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	EIF2AK4	0.31	-0.01	enet	11	0.06	6.4e-03	-6.82	-5.9	3.3e-09	0.42	0.07	0.11	FALSE
23	GTEx	Cells Transformed fibroblasts	DNAJC17	0.11	0.11	lasso	3	0.11	6.7e-09	4.54	5.4	8.0e-08	-0.02	0.98	0.00	FALSE
24	GTEx	Colon Sigmoid	NDUFAF1	0.15	0.06	lasso	4	0.06	5.2e-03	6.42	-7.1	1.1e-12	-0.01	0.28	0.30	FALSE
25	GTEx	Colon Transverse	EIF2AK4	0.40	0.16	lasso	4	0.15	9.2e-08	-7.28	-8.4	6.4e-17	0.87	0.00	1.00	FALSE
26	GTEx	Esophagus Mucosa	EIF2AK4	0.30	0.11	lasso	6	0.14	9.4e-10	-7.28	-8.3	1.1e-16	0.87	0.00	1.00	FALSE
27	GTEx	Esophagus Mucosa	NDUFAF1	0.25	0.18	enet	26	0.24	4.3e-16	6.42	-5.5	3.4e-08	0.01	1.00	0.00	FALSE
28	GTEx	Esophagus Mucosa	CHP1	0.19	0.10	lasso	7	0.09	1.4e-06	7.35	-7.0	1.8e-12	-0.03	0.17	0.83	FALSE
29	GTEx	Esophagus Muscularis	EIF2AK4	0.28	0.09	enet	15	0.20	5.3e-12	0.41	-5.4	5.2e-08	0.50	0.18	0.82	FALSE
30	GTEx	Heart Left Ventricle	EHD4	0.20	0.14	lasso	3	0.12	7.8e-07	5.33	-5.2	1.6e-07	-0.05	0.91	0.02	FALSE
31	GTEx	Lung	EIF2AK4	0.14	0.12	enet	10	0.12	2.0e-09	-7.28	-6.7	1.8e-11	0.67	0.11	0.89	FALSE
32	GTEx	Lung	OIP5-AS1	0.09	0.08	enet	14	0.12	2.8e-09	7.95	6.9	3.8e-12	0.03	0.10	0.90	FALSE
33	GTEx	Nerve Tibial	EHD4	0.20	0.04	lasso	7	0.08	2.4e-06	4.03	-5.6	2.4e-08	-0.06	0.81	0.15	FALSE
34	GTEx	Nerve Tibial	MAPKBP1	0.09	0.05	lasso	3	0.08	3.5e-06	6.63	-5.1	3.0e-07	-0.01	0.01	0.99	TRUE
35	GTEx	Nerve Tibial	NUSAP1	0.15	0.09	enet	10	0.15	9.8e-11	2.30	5.5	5.1e-08	0.03	0.80	0.20	FALSE
36	GTEx	Pancreas	EIF2AK4	0.40	0.29	lasso	5	0.29	7.6e-13	-8.86	-9.1	7.2e-20	0.94	0.00	1.00	TRUE
37	GTEx	Pancreas	OIP5-AS1	0.07	0.13	lasso	2	0.10	7.5e-05	5.61	5.2	1.7e-07	-0.01	0.56	0.13	FALSE
38	GTEx	Skin Not Sun Exposed Suprapubic	NDUFAF1	0.16	0.06	lasso	3	0.07	1.7e-04	6.42	-7.3	3.8e-13	0.02	0.10	0.10	FALSE
39	GTEx	Skin Not Sun Exposed Suprapubic	PLA2G4B	0.17	0.18	lasso	5	0.18	2.9e-10	6.67	6.7	2.2e-11	-0.02	0.02	0.98	FALSE
40	GTEx	Skin Sun Exposed Lower leg	DNAJC17	0.08	0.04	enet	9	0.02	5.6e-03	5.03	5.9	3.9e-09	0.03	0.11	0.45	FALSE
41	GTEx	Skin Sun Exposed Lower leg	EIF2AK4	0.34	0.15	enet	16	0.15	9.4e-13	-8.86	-8.0	1.8e-15	0.93	0.00	1.00	FALSE
42	GTEx	Skin Sun Exposed Lower leg	CHP1	0.06	0.04	enet	9	0.04	3.1e-04	7.95	-7.6	3.7e-14	-0.03	0.04	0.93	FALSE
43	GTEx	Skin Sun Exposed Lower leg	PLA2G4B	0.16	0.18	lasso	3	0.17	2.5e-14	6.67	6.7	2.4e-11	-0.02	0.02	0.98	FALSE
44	GTEx	Stomach	EIF2AK4	0.21	0.13	lasso	7	0.11	4.9e-06	-7.28	-6.9	6.6e-12	0.70	0.02	0.94	FALSE
45	GTEx	Testis	OIP5-AS1	0.14	0.16	lasso	1	0.14	8.6e-07	5.61	5.6	2.0e-08	-0.02	0.75	0.10	FALSE
46	GTEx	Thyroid	EIF2AK4	0.31	0.18	enet	15	0.23	3.0e-17	-7.28	-8.2	1.8e-16	0.90	0.00	1.00	FALSE
47	GTEx	Thyroid	RTF1	0.28	0.27	lasso	3	0.26	8.4e-20	-5.98	-6.0	2.0e-09	-0.04	1.00	0.00	FALSE
48	GTEx	Thyroid	PLA2G4B	0.14	0.09	enet	11	0.08	1.6e-06	6.79	8.2	1.5e-16	0.00	0.01	0.99	TRUE
49	GTEx	Thyroid	OIP5-AS1	0.20	0.19	lasso	8	0.20	4.1e-15	5.62	6.1	1.4e-09	0.00	1.00	0.00	FALSE
50	GTEx	Thyroid	SRP14-AS1	0.17	0.05	enet	17	0.04	9.1e-04	6.92	5.5	2.9e-08	-0.57	0.19	0.28	FALSE
51	GTEx	Thyroid	RP11-111A22.1	0.16	0.20	enet	19	0.21	3.1e-16	-4.92	6.0	2.8e-09	-0.03	1.00	0.00	FALSE
52	METSIM	Adipose	BAHD1	0.04	0.05	enet	12	0.05	2.2e-08	4.64	-6.2	4.3e-10	0.14	1.00	0.00	TRUE
53	METSIM	Adipose	EIF2AK4	0.24	0.04	enet	25	0.17	1.1e-24	-7.28	-5.2	1.7e-07	0.64	0.00	1.00	FALSE
54	METSIM	Adipose	JMJD7	0.16	0.20	lasso	11	0.22	5.6e-32	-5.77	5.7	1.1e-08	0.03	0.95	0.05	FALSE
55	NTR	Blood	INO80	0.02	0.02	enet	8	0.03	2.8e-09	7.72	-7.4	1.1e-13	-0.04	0.04	0.96	TRUE
56	NTR	Blood	RTF1	0.04	0.02	blup	338	0.03	6.9e-09	-6.21	5.4	7.8e-08	-0.01	0.22	0.78	FALSE
57	YFS	Blood	MGA	0.01	0.00	blup	454	0.00	7.1e-02	6.60	7.7	2.1e-14	0.02	0.02	0.82	FALSE
58	YFS	Blood	PLA2G4B	0.07	0.11	bslmm	409	0.12	1.6e-35	6.72	7.0	2.2e-12	-0.03	0.02	0.98	FALSE
59	YFS	Blood	SRP14	0.56	0.35	enet	68	0.54	4.4e-213	-7.09	-7.8	9.5e-15	0.79	1.00	0.00	FALSE
60	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	JMJD7-PLA2G4B	0.04	0.00	enet	8	0.01	2.8e-02	6.63	6.0	2.0e-09	0.02	0.00	0.91	FALSE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHP	0.01	0.01	blup	54	0.01	1.4e-02	7.98	-7.8	4.9e-15	-0.01	0.01	0.89	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	EIF2AK4	0.05	0.03	lasso	7	0.03	9.5e-07	-8.80	-8.1	7.1e-16	0.90	0.00	1.00	FALSE
63	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	NDUFAF1	0.16	0.02	blup	28	0.05	2.1e-03	5.86	-5.7	1.3e-08	0.08	0.00	0.89	FALSE
64	The Cancer Genome Atlas	Esophageal Carcinoma	EIF2AK4	0.16	0.07	lasso	6	0.13	7.2e-05	-8.80	-7.3	2.2e-13	0.82	0.00	0.93	FALSE
65	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EIF2AK4	0.11	0.04	lasso	4	0.06	2.1e-07	-8.86	-7.3	2.7e-13	0.84	0.00	1.00	FALSE
66	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	JMJD7-PLA2G4B	0.04	0.02	lasso	3	0.02	1.9e-03	6.67	6.6	5.5e-11	-0.02	0.00	0.95	FALSE
67	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INO80	0.03	0.02	blup	38	0.03	1.1e-02	2.79	5.8	6.6e-09	0.04	0.02	0.49	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	JMJD7-PLA2G4B	0.07	0.02	enet	7	0.03	3.2e-04	6.67	5.7	1.1e-08	-0.02	0.00	0.96	FALSE
69	The Cancer Genome Atlas	Lung Adenocarcinoma	EIF2AK4	0.09	0.02	enet	10	0.04	8.2e-06	-7.28	-5.2	2.2e-07	0.58	0.20	0.32	FALSE
70	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EIF2AK4	0.22	0.06	lasso	4	0.10	6.9e-05	2.23	-5.6	2.3e-08	0.64	0.02	0.82	FALSE
71	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	INO80	0.07	0.04	blup	40	0.06	1.2e-03	4.50	7.2	4.9e-13	0.03	0.02	0.82	FALSE
72	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC729082	0.31	0.00	blup	43	0.00	5.5e-01	5.25	6.5	8.2e-11	0.03	0.01	0.38	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHP	0.21	0.11	lasso	4	0.12	5.1e-13	3.09	-5.7	1.6e-08	0.01	0.26	0.74	FALSE
74	The Cancer Genome Atlas	Rectum Adenocarcinoma	RPAP1	0.37	0.10	blup	56	0.08	5.5e-03	-3.22	-6.0	1.8e-09	0.00	0.02	0.10	FALSE
75	The Cancer Genome Atlas	Stomach Adenocarcinoma	EIF2AK4	0.06	0.01	blup	105	0.02	1.5e-02	3.34	-6.2	6.5e-10	0.59	0.01	0.76	FALSE
76	The Cancer Genome Atlas	Thyroid Carcinoma	EIF2AK4	0.15	0.07	lasso	5	0.09	4.9e-09	-8.86	-8.3	7.5e-17	0.91	0.00	1.00	FALSE
77	The Cancer Genome Atlas	Thyroid Carcinoma	INO80	0.03	0.02	blup	39	0.03	1.0e-03	3.35	7.1	1.0e-12	0.04	0.02	0.95	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	RTF1	0.04	0.02	lasso	3	0.02	4.0e-03	-5.98	-5.7	1.1e-08	-0.04	0.01	0.91	TRUE