Hub : Genes

DEGS2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1590	0.0690	0.00700	-0.003	NA	-0.001	NA	-0.002	0.82000	NA	0.3800	NA	0.5200
2	METSIM	Adipose	0.0488	0.0190	0.00097	0.008	0.018	-0.001	0.018	0.008	0.01900	0.00086	0.4600	0.00094	0.0200
3	TCGA	Brain Lower Grade Glioma	0.0274	0.0151	0.00290	0.013	0.014	0.013	NA	0.014	0.01100	0.00790	0.0100	NA	0.0093
4	TCGA	Thyroid Carcinoma	0.0420	0.0220	0.00360	0.030	0.029	0.017	NA	0.019	0.00063	0.00076	0.0078	NA	0.0054

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.0	1.5	5.1	0.7	-2.2	-0.4	-0.6
Bipolar Disorder or Schizophrenia	0.3	0.8	2.1	-0.7	-1.5	0.3	0.8
Depressed Affect (Nagel 2018)	0.9	1.8	6.0	1.0	-2.4	-0.5	0.2
Depression (Nagel 2018)	0.6	0.8	3.2	-0.2	-1.8	-0.2	-0.0
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.5	-0.2	-1.5	-1.6	-0.2
Neuroticism (Nagel 2018)	0.6	1.5	5.0	0.6	-2.2	-0.7	-0.0
Schizophrenia (2018)	0.6	1.2	2.3	-1.5	-0.0	0.7	1.5
Schizophrenia vs Biploar Disorder	1.0	1.3	3.2	0.8	0.7	0.9	1.8
Worry (Nagel 2018)	0.5	1.0	2.7	0.3	-1.6	-1.0	0.1
Alzheimer’s Disease (in mother)	1.3	1.5	2.6	-1.1	-0.3	1.6	1.4
Alzheimer’s Disease (in father)	0.5	0.5	0.9	0.2	-0.6	1.0	0.9
Alzheimer’s Disease (including proxy)	0.8	1.1	2.6	-0.3	-0.2	1.6	1.3
Crohns Disease (2017)	0.4	0.9	2.8	0.4	-1.7	-0.1	0.7
Irritable Bowel Disease (IBD)	0.6	1.4	2.4	1.3	-1.5	-0.5	1.1
Ulcerative Colitis (UC)	0.4	0.8	1.7	1.3	-0.6	-0.2	1.1
Major Depression (MDD)	0.6	0.7	2.6	-0.4	-1.6	0.0	0.0
Reaction Time	0.1	0.3	0.4	0.6	-0.5	0.4	0.5
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.0	-0.8	-1.7	-1.4	-1.1
Breast Cancer	0.4	0.9	2.0	-0.2	1.2	-0.2	-1.4
Ovarian Cancer	0.2	0.3	0.9	-0.1	1.0	0.4	0.4
Prostate Cancer	1.2	1.6	4.4	0.3	2.1	1.4	-0.3
Age at First Birth	1.6	2.4	7.9	0.9	-2.8	-0.8	0.4
Bipolar Disorder (2011)	1.3	1.2	2.5	-1.6	-0.2	1.5	-0.4
Body Mass Index (BMI) (2010)	1.0	1.3	2.2	-1.3	1.5	-0.8	-0.9
Coronary Artery Disease (CAD)	1.5	1.8	3.9	-0.5	-0.1	-1.7	-2.0
Crohns Disease (2012)	0.4	0.6	1.4	0.7	-1.2	-0.0	0.8
Mean Putamen Volume	1.7	1.9	6.3	-0.9	2.5	-0.2	-0.7
Fasting Glucose	1.6	2.0	3.3	0.2	-1.6	-1.8	-1.3
HbA1C	1.1	1.2	2.2	-0.8	-1.5	-1.4	-0.0
HDL Cholesterol	0.7	1.1	2.6	0.5	-0.9	1.6	0.9
LDL Cholesterol	0.3	0.5	1.4	0.7	1.2	-0.3	0.1
Lupus	1.1	1.7	3.0	-1.7	0.7	-1.1	-1.4
Neuroticism (2016)	0.9	1.3	2.6	-0.8	-0.2	1.6	1.3
Primary Biliary Cirrhosis	0.4	0.5	1.9	-0.4	-0.2	-0.2	1.4
Rheumatoid Arthritis	0.1	0.1	0.2	-0.5	0.2	0.4	0.1
Schizophrenia (2014)	0.4	1.0	2.9	-0.5	-0.8	0.5	1.7
Triglycerides	0.4	0.6	1.8	-0.0	1.3	-0.5	-0.7
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.4	0.0	0.0	-1.0	-1.5
Ulcerative Colitis	0.5	0.8	1.5	1.2	0.3	0.6	1.0
Blood Eosinophil Count	0.4	3.2	5.7	0.7	2.4	2.1	1.5
Blood Platelet Count	0.1	1.0	2.4	0.1	-1.2	-0.5	1.6
Blood Red Count	0.6	5.3	12.1	0.9	-2.1	-3.5	-2.0
Blood White Count	0.4	2.7	5.6	-0.6	1.2	1.8	2.4
Heel T-Score	0.5	4.4	9.8	-1.5	0.4	-3.1	-2.3
BMI	0.3	1.6	5.4	2.3	-0.6	-0.6	-0.1
Height	0.1	1.5	3.3	-0.2	1.6	0.3	-1.8
Waist Hip Ratio (WHR)	0.2	0.7	1.1	-0.2	-0.8	1.1	1.1
Systolic Blood Pressure	2.2	11.1	29.3	-1.2	1.1	-5.4	-3.5
Smoking Status	1.3	3.1	6.1	-0.9	2.5	-0.5	-2.3
Allergy or Eczema	0.5	1.2	4.4	0.5	0.5	2.1	0.3
Cardiovascular Disease	1.3	4.4	11.3	1.9	-0.3	-3.4	-1.6
Hypothyroidism (self reported)	0.3	0.8	1.8	1.1	0.0	-1.3	-0.3
Respiratory disease	0.4	0.9	2.1	0.7	0.7	1.5	0.6
Type 2 Diabetes (T2D) (2018)	1.1	2.0	4.8	-0.1	0.5	-2.2	-1.8
Lung FEV1/FVC ratio	0.7	3.8	5.7	-1.4	-2.4	2.1	1.8
Lung FVC	0.4	1.9	3.7	-1.8	1.9	0.9	-0.2
Neuroticism	0.8	2.0	5.7	0.2	-2.4	-1.4	-0.4
Chronotype (morning person)	0.5	1.1	2.8	0.3	-0.2	-1.2	-1.7
Hair Pigment	0.0	1.1	3.2	-1.8	1.0	0.6	0.1
Tanning	0.2	2.2	3.7	-0.9	1.9	-1.7	-1.3
Hand grip strength (left)	0.6	1.6	3.3	-1.5	0.5	-1.8	-0.9
Number of treatments/medications taken	1.0	1.8	4.6	1.2	-2.1	-0.4	0.8
Average weekly spirits intake	0.2	0.2	0.4	-0.6	0.5	0.5	0.2
Sensitivity / hurt feelings	0.5	0.8	1.5	-0.2	-1.1	-0.7	-1.2
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.4	-0.2	-1.2	-0.7	-0.4
Hearing difficulty/problems: Yes	1.1	1.7	5.5	0.5	-0.5	-2.3	-1.0
Relative age of first facial hair	0.4	0.9	2.1	-0.2	1.4	1.2	0.4
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.3	1.1	0.5	-0.4	0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.7	-0.8	-1.3	0.0	-0.9
Ever had hysterectomy (womb removed)	0.3	0.3	1.0	0.1	0.4	0.2	1.0
Systolic blood pressure, automated reading	2.3	6.7	14.9	-0.3	1.0	-3.9	-3.3
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	3.3	0.1	0.2	-1.7	-1.8
Angina	1.1	1.5	4.7	-0.1	-2.2	-0.8	-0.8
Medication for hormone replacement therapy	1.4	1.5	4.8	0.7	0.5	-0.7	-2.2
Vitamin and mineral supplements	0.4	0.6	1.5	-0.2	-0.9	-1.2	0.1
Supplements: Zinc	2.4	2.7	3.4	1.5	1.5	1.6	1.8
Medication: Co-codamol	0.6	0.7	1.0	0.8	-0.6	1.0	0.9
Medication: Metformin	0.0	0.0	0.1	0.2	0.2	0.3	0.1
Diabetes (father)	1.0	1.3	3.5	0.9	-1.9	-0.2	0.8
Diabetes (mother)	0.8	1.0	1.9	-1.0	-0.8	0.6	1.4
Severe depression (siblings)	0.3	0.3	1.0	1.0	0.2	0.6	0.1
Pack years adult smoking proportion	0.9	1.4	2.6	-1.6	-0.4	-1.3	-1.1
Impedance of leg (right)	0.3	1.3	3.2	-0.7	-1.0	1.8	0.8
Leg fat-free mass (left)	0.2	1.2	2.4	1.4	0.5	-1.6	-0.7
Trunk fat percentage	0.5	1.8	3.5	1.1	-1.9	0.7	1.4
Hand grip strength (right)	0.4	1.1	2.6	-0.5	1.6	-1.0	-0.7
Townsend deprivation index at recruitment	0.1	0.2	0.5	0.5	0.7	0.1	0.1
Current tobacco smoking	0.2	0.4	1.5	-1.2	0.1	-0.2	0.1
Average weekly fortified wine intake	1.2	1.4	4.6	2.2	0.0	-0.0	0.9
Maternal smoking around birth	0.2	0.3	0.7	0.9	0.1	0.8	-0.1
Fed-up feelings	1.4	2.6	4.6	-1.0	-1.1	-2.1	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.6	-0.7	-1.2	0.1	0.5
Relative age voice broke	0.3	0.4	1.0	0.1	1.0	0.8	-0.1
Taking other prescription medications	0.2	0.3	0.5	-0.0	-0.4	0.7	0.6
Age when periods started (menarche)	2.5	6.1	8.6	2.4	2.9	2.6	1.7
Bilateral oophorectomy (both ovaries removed)	2.1	2.4	5.7	1.9	-2.4	-0.4	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.8	0.1	-0.9	0.0	0.7
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	6.2	0.2	-2.5	0.5	0.7
Qualifications: CSEs or equivalent	0.7	0.9	1.5	-1.1	-1.2	-0.8	-0.4
Serious illness, injury or assault to yourself	0.9	1.1	2.7	1.2	-1.6	0.4	0.1
High blood pressure	2.3	6.4	17.6	1.1	-1.3	-4.2	-2.2
Hayfever, allergic rhinitis or eczema	0.6	1.3	4.1	0.5	0.6	2.0	0.7
Multivitamins +/- minerals	0.6	0.8	2.5	0.6	0.4	1.6	0.4
Stomach or abdominal pain in last month	0.4	0.5	1.1	-1.0	0.6	0.6	0.1
Supplements: Glucosamine	1.4	1.8	4.7	-0.9	0.5	2.2	1.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	0.2	-0.4	0.7	-0.4
Medication: Atenolol	0.6	0.8	2.6	-0.3	-1.6	0.1	0.6
Medication: Levothyroxine sodium	1.1	1.9	3.6	1.5	-1.2	-1.9	-0.6
Sitting height	0.2	1.7	3.7	-0.0	0.9	-1.6	-1.9
Chronic bronchitis/emphysema (father)	0.5	0.5	1.9	-0.4	-0.1	1.4	0.3
High blood pressure (mother)	1.5	2.1	4.9	-0.9	-2.2	-1.6	-0.4
Body mass index (BMI)	0.2	0.8	1.1	1.0	-1.1	-1.0	0.3
Impedance of leg (left)	0.4	2.0	5.0	-0.9	-1.0	2.2	1.1
Leg predicted mass (left)	0.2	1.3	2.4	1.3	0.5	-1.6	-0.8
Trunk fat mass	0.2	0.9	1.7	1.3	-1.2	-0.1	0.6
Waist circumference	0.4	1.6	3.1	1.8	-1.6	-0.6	0.6
Number of incorrect matches in round	0.2	0.4	1.1	0.0	0.5	-0.5	-1.0
Past tobacco smoking	1.7	3.1	6.5	0.1	-2.6	0.2	2.4
Alcohol usually taken with meals	0.7	1.1	2.4	1.5	-0.2	1.2	0.8
Nervous feelings	0.2	0.4	0.8	0.7	-0.9	-0.4	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	-0.6	-1.0	0.2	0.2
Hearing difficulty/problems with background noise	1.2	1.9	4.6	-0.5	-0.7	-2.1	-1.5
Hair/balding pattern: Pattern 2	0.9	1.1	1.5	1.2	-0.8	0.9	1.2
Had menopause	0.8	0.9	2.9	0.5	1.7	0.8	-0.4
Had other major operations	3.1	3.8	7.1	2.7	-1.8	-2.1	-1.0
Forced vital capacity (FVC)	0.9	3.4	6.0	-1.6	2.4	-1.1	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	-0.1	-0.4	0.4	0.8
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.4	-0.9	-1.2	-0.9	-0.8
Qualifications: None of the above	0.6	1.2	3.3	-1.8	0.3	-0.4	-1.1
Financial difficulties in last 2 years	0.4	0.5	1.6	0.1	-0.6	-0.1	1.3
Mouth/teeth dental problems	0.3	0.4	1.0	-1.0	0.7	-0.2	-0.2
Heart attack	0.3	0.3	0.6	-0.3	-0.7	0.5	0.7
Allergy	0.2	0.5	1.3	0.3	-0.8	-1.1	-0.0
Pain all over the body in last month	0.4	0.4	1.5	-0.0	0.3	1.2	-0.2
Diabetes (self-reported)	0.8	1.2	1.9	1.3	0.2	-1.4	-1.1
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.4	1.2	0.2	0.9	1.1
Medication: Ramipril	0.3	0.4	1.1	0.2	-0.6	-1.1	0.0
Medication: Simvastatin	2.2	3.2	4.5	0.4	-2.0	-2.1	-2.0
Fluid intelligence score	0.6	1.3	3.0	-0.9	-1.7	-1.0	-0.6
Illnesses of siblings	0.6	0.9	1.5	-0.6	1.0	0.7	-1.2
Neuroticism score	0.6	1.3	2.8	0.1	-1.7	-1.4	-0.7
Weight	0.2	1.1	2.3	1.3	-0.6	-1.5	-0.5
Impedance of arm (right)	0.6	2.7	4.1	-0.9	-1.7	2.0	1.7
Arm fat percentage (right)	0.4	1.8	5.2	0.7	-2.3	-0.6	1.0
Trunk fat-free mass	0.6	3.3	6.7	1.3	1.0	-2.6	-2.0
Hip circumference	0.5	2.1	4.4	2.1	-1.4	-1.3	0.3
Time employed in main current job	2.3	2.7	9.9	-0.1	3.1	0.4	-0.7
Alcohol intake versus 10 years previously	1.9	2.8	7.4	1.1	-1.2	-2.7	-1.1
Father’s age at death	1.7	2.2	4.1	0.9	0.2	2.0	2.0
Worrier / anxious feelings	0.6	1.1	1.9	0.3	-1.3	-1.4	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.7	-0.6	-0.6	-0.3	-0.9
Falls in the last year	0.6	0.8	1.4	-0.8	-1.2	0.2	1.0
Hair/balding pattern: Pattern 3	0.3	0.5	1.8	0.2	1.3	-0.4	-0.2
Number of live births	0.5	0.7	1.3	-0.4	0.6	1.2	0.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.1	-1.2	1.4	-0.3	-0.8
Pulse rate	1.2	2.0	3.8	0.7	0.9	1.9	1.7
Happiness	1.3	1.6	3.1	-0.6	-0.7	-1.6	-1.8
Noisy workplace	0.4	0.5	1.2	-0.8	0.1	-0.1	-1.1
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.7	0.4	-1.3	-1.1	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.6	-1.3	-0.1	0.8	0.3
Mouth/teeth dental problems: Dentures	0.5	0.9	2.7	1.6	-0.7	0.7	-0.2
Asthma	0.2	0.4	1.3	-0.1	1.1	0.5	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.5	-0.4	0.2	1.6	0.8
Medication: Cholesterol lowering	0.1	0.2	0.3	-0.4	-0.6	-0.4	-0.3
Depression (self-reported)	2.1	2.5	7.0	0.8	-0.1	1.5	2.6
Medication: Lansoprazole	1.0	1.2	3.2	1.1	-0.1	1.8	0.3
Prospective memory result	0.2	0.2	0.6	0.8	0.5	0.0	0.4
Lung cancer (father)	0.6	0.7	2.1	1.4	0.8	-0.3	-0.1
Illnesses of mother	1.3	1.6	3.2	1.7	1.8	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	3.5	-1.5	1.9	-1.1	-1.7
Pulse wave Arterial Stiffness index	0.5	0.5	1.3	-0.5	0.1	0.8	1.1
Impedance of arm (left)	0.6	2.9	4.5	-0.6	-2.1	2.0	1.7
Arm fat mass (right)	0.3	1.0	1.8	1.3	-1.4	-0.6	0.6
Trunk predicted mass	0.6	3.4	6.7	1.3	1.0	-2.6	-2.0
Standing height	0.1	1.1	2.0	0.9	1.0	-0.9	-1.4
Length of working week for main job	0.4	0.4	0.6	-0.8	0.6	0.8	-0.1
Exposure to tobacco smoke at home	0.5	0.6	1.3	-1.1	-0.8	0.4	0.3
Breastfed as a baby	0.6	0.7	1.4	-0.4	1.2	-0.7	-1.0
Tense / ‘highly strung’	0.2	0.4	0.9	-1.0	-0.8	0.2	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.8	0.9	-0.5	-0.5	-0.6
Hair/balding pattern: Pattern 4	0.6	1.5	3.5	-1.9	-1.2	0.7	0.5
Birth weight of first child	0.2	0.4	0.8	-0.4	-0.9	-0.5	0.7
Peak expiratory flow (PEF)	0.3	0.7	1.8	-0.8	1.4	0.0	-0.4
Pulse wave reflection index	0.8	1.0	2.1	-1.4	-1.3	-0.5	-0.1
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.9	0.2	-0.1	-1.3	-1.4
Loud music exposure frequency	1.4	1.5	2.3	-0.4	1.5	-1.2	-1.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	0.1	-0.2	0.4	0.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.1	-1.0	0.3	-1.0	-0.4
Blood clot in the leg (DVT)	0.2	0.2	0.8	0.2	-0.0	-0.1	-0.9
Medication: Paracetamol	3.3	5.5	7.4	1.6	-2.2	2.7	2.7
Headache pain in last month	0.1	0.2	0.4	0.3	-0.7	0.3	0.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	2.8	-0.2	0.9	1.7	0.8
Glaucoma (self-reported)	1.1	1.3	4.5	2.1	0.8	0.4	-0.0
Gout (self-reported)	0.4	0.5	1.0	-1.0	-0.7	-0.6	-0.4
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.6	0.5	-0.6	-1.6	-0.7
Medication: Amlodipine	3.2	4.5	8.5	-0.1	1.4	-2.9	-2.8
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.6	1.3	1.0	-0.1	-0.6
Birth weight	0.4	0.8	2.1	0.2	0.2	1.4	1.0
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	-0.5	-0.0	0.2	-0.5
High blood pressure (siblings)	0.6	0.9	1.1	1.0	-1.1	-0.7	0.9
Forced vital capacity (FVC), Best measure	1.7	6.1	8.9	-1.9	3.0	-1.7	-2.9
Body fat percentage	0.4	1.7	4.2	0.9	-2.1	0.3	1.2
Leg fat percentage (right)	0.3	1.0	2.3	1.1	-1.5	-0.0	0.6
Arm fat-free mass (right)	0.4	2.0	2.3	1.3	1.3	-1.5	-1.5
Exposure to tobacco smoke outside home	0.9	1.2	2.8	-0.9	-0.2	-1.7	-1.1
Comparative body size at age 10	0.9	2.6	7.2	-0.7	-0.6	-2.7	-1.5
Number of full brothers	0.1	0.2	0.5	0.0	-0.7	-0.2	0.3
Worry too long after embarrassment	0.4	0.7	1.8	1.3	-0.4	-0.8	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.3	0.8	-0.4	-0.5
Wheeze or whistling in the chest in last year	0.4	0.7	1.8	-0.0	1.4	-0.8	-0.6
Number of children fathered	0.6	0.6	1.5	0.7	-1.2	0.8	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.8	-0.4	-0.4	-0.8	-1.7
Age at first live birth	1.2	2.0	4.1	0.6	-2.0	0.4	1.9
Pulse wave peak to peak time	0.7	0.8	1.6	0.8	0.1	-0.9	-1.3
Health satisfaction	1.6	2.1	5.4	-0.1	-2.3	-1.4	-1.0
Shortness of breath walking on level ground	0.9	1.1	2.1	0.7	-1.5	-1.1	0.8
Qualifications: College or University degree	0.1	0.4	0.8	-0.7	-0.9	-0.0	0.6
Eye problems/disorders: None of the above	2.0	2.3	6.0	-1.5	-0.5	0.9	2.4
Mouth/teeth dental problems: Loose teeth	2.4	2.8	5.8	0.3	0.8	2.4	2.2
Emphysema/chronic bronchitis	2.4	2.7	8.4	-0.0	0.0	-2.9	-1.6
Medication for pain relief, constipation, heartburn	2.1	3.6	8.6	-0.1	2.9	-1.8	-1.6
Neck or shoulder pain in last month	1.6	2.3	5.9	0.9	0.5	2.4	1.4
Medication: Blood pressure	1.6	2.9	8.3	0.1	-1.1	-2.9	-1.4
Angina (self-reported)	1.1	1.4	3.9	-0.0	-2.0	-0.9	-1.0
Migraine (self-reported)	1.6	2.0	4.9	0.6	0.6	2.2	1.5
Medication: Ibuprofen	0.6	0.7	1.8	0.4	0.2	1.3	0.9
Medication: Allopurinol	0.2	0.3	0.7	-0.8	-0.6	-0.2	0.0
Medication: Omeprazole	1.6	1.9	4.2	-2.0	-1.8	0.2	-0.1
Medication: Seretide 50 evohaler	1.0	1.2	3.7	-0.9	1.9	0.5	-0.0
Mean time to correctly identify matches	0.2	0.5	0.7	0.7	-0.5	0.8	0.7
Heart disease (mother)	0.6	0.7	1.2	-0.1	-0.7	1.1	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.6	-0.4	-1.3	0.6	0.7
Whole body fat mass	0.2	0.8	1.5	1.2	-1.2	-0.4	0.4
Leg fat mass (right)	0.1	0.6	1.4	1.2	-0.8	-0.3	0.2
Arm predicted mass (right)	0.4	2.0	2.6	1.0	1.5	-1.6	-1.5
Pulse rate, automated reading	0.3	1.1	2.6	0.5	-1.0	0.6	1.6
Alcohol intake frequency.	0.8	1.8	5.2	0.5	-1.0	-2.3	-0.9
Comparative height size at age 10	0.4	2.4	4.9	-0.3	-0.4	-2.2	-2.1
Number of full sisters	0.7	0.8	1.4	1.2	-1.1	0.1	0.8
Suffer from ‘nerves’	0.1	0.2	0.5	0.6	-0.1	-0.1	0.7
Overall health rating	0.1	0.2	0.7	0.1	-0.1	-0.4	-0.8
Chest pain or discomfort	0.3	0.5	1.9	0.1	-1.4	0.1	-0.3
Had major operations	3.5	4.1	10.8	0.2	-3.3	-2.3	-0.3
Age at last live birth	0.8	1.1	3.3	0.3	-1.8	-1.0	0.2
Family relationship satisfaction	2.5	3.1	6.8	-1.8	0.6	-1.4	-2.6
Leg pain on walking	1.5	1.9	4.9	2.2	-1.4	0.1	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.3	1.5	0.5	-0.5	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.5	-0.4	0.4	0.6
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	1.9	-0.9	1.4	-0.4	-1.2
Medication: Aspirin	1.4	1.8	3.2	-0.4	-1.8	-1.6	-1.2
Supplements: Vitamin C	1.8	2.1	5.3	-1.2	2.3	1.2	0.5
Knee pain experienced in last month	0.2	0.4	0.9	0.1	-0.2	-1.0	-0.7
Hypertension (Self-reported)	2.0	5.5	14.6	1.0	-1.1	-3.8	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.9	0.3	-0.5	1.7	1.1
Illnesses of father: Heart disease	0.1	0.2	0.7	0.0	-0.8	-0.1	-0.4
Illnesses of siblings: Diabetes	0.1	0.1	0.4	0.2	-0.6	-0.1	0.2
Smoking status: Previous	2.3	3.5	7.0	0.9	2.3	-0.7	-2.6
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	3.9	-0.4	-0.2	-2.0	-2.0
Whole body fat-free mass	0.4	2.4	4.5	1.4	0.9	-2.1	-1.5
Leg fat-free mass (right)	0.2	1.1	1.9	1.2	0.7	-1.4	-0.7
Arm fat percentage (left)	0.4	1.7	5.0	0.8	-2.2	-0.4	1.0
Average weekly red wine intake	0.9	1.3	2.0	1.4	1.2	1.1	0.7
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.5	-1.6	-0.4	-0.1	-0.6
Mood swings	0.9	1.6	5.3	0.0	-2.3	-1.0	-0.3
Loneliness, isolation	0.8	1.1	3.4	0.9	-1.8	-0.5	0.4
Long-standing illness, disability or infirmity	0.2	0.4	1.1	1.1	0.2	-0.4	0.4
Ever had bowel cancer screening	1.3	1.5	4.7	0.5	-0.2	1.1	2.2
Diabetes diagnosed by doctor	0.8	1.4	3.6	0.5	0.0	-1.9	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.2	0.0	0.2	-0.4
Friendships satisfaction	0.6	0.7	2.3	0.0	-1.5	-0.3	0.6
Qualifications: nursing, teaching	0.4	0.6	1.1	0.5	1.1	0.8	0.7
Commuting to job workplace: Walk	1.5	1.6	3.5	-1.5	1.9	-0.3	-0.8
Eye problems/disorders: Cataract	0.6	0.7	2.0	-0.6	-0.1	-0.5	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	1.8	1.3	0.5	0.6	1.0
Medication for cholesterol	2.8	4.2	9.1	-0.9	1.6	3.0	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.7	-0.7	-1.9	0.5	0.4
Back pain experienced in last month	0.5	0.7	2.6	1.6	-0.4	-0.4	0.2
Mineral and other dietary supplements	1.2	1.6	3.3	1.8	-0.9	-1.4	-0.6
Breast cancer (self-reported)	0.9	1.1	3.0	1.7	0.0	0.6	-1.0
Asthma (self-reported)	0.2	0.5	1.7	-0.1	1.3	0.2	-0.1
Osteoporosis (self-reported)	1.1	1.3	2.7	-0.7	0.3	1.4	1.6
Osteoarthritis (self-reported)	0.9	1.2	1.7	1.3	-1.2	1.0	0.8
Medication: Aspirin	1.1	1.5	2.9	-0.3	-1.4	-1.7	-1.1
Medication: Gliclazide	0.7	0.8	1.5	-0.9	-0.8	-1.2	0.3
Illnesses of father: None of the above (group 1)	0.7	0.9	1.1	0.7	1.1	0.9	1.1
Smoking status: Current	0.4	0.6	2.1	-1.5	-0.2	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.9	-2.0	0.1	-0.4	-0.6
Whole body water mass	0.4	2.4	4.6	1.4	1.0	-2.1	-1.5
Leg predicted mass (right)	0.2	1.1	1.9	1.2	0.7	-1.4	-0.7
Arm fat mass (left)	0.3	1.0	1.9	1.2	-1.4	-0.8	0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.5	-0.7	-0.2	0.1
Average weekly champagne plus white wine intake	1.1	1.5	3.6	-0.6	0.6	1.9	1.3
Miserableness	1.4	2.3	6.3	0.1	-2.5	-0.3	1.7
Guilty feelings	0.9	1.3	2.9	0.4	-1.1	-1.7	-1.0
Wears glasses or contact lenses	1.3	1.5	3.9	2.0	1.3	0.3	0.6
Ever taken oral contraceptive pill	0.9	1.1	2.8	-0.5	0.4	-1.7	-1.0
Hearing aid user	1.7	1.9	4.7	1.6	-0.4	-2.2	-0.7
Mother’s age at death	0.9	1.1	2.1	1.0	0.0	1.5	1.1
Financial situation satisfaction	0.2	0.2	0.4	0.6	-0.3	0.6	0.2
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.2	1.5	-1.0	0.8	1.4
Commuting to job workplace: Public transport	0.2	0.3	0.8	-0.5	-0.4	-0.2	-0.9
Eye problems/disorders: Glaucoma	1.5	1.8	6.4	2.5	0.7	0.5	-0.0
Medication: Blood pressure	1.4	2.7	6.3	0.2	-1.6	-2.5	-1.3
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.5	-1.4	1.6	0.3	-0.9
Supplements: Fish oil (including cod liver oil)	1.1	1.4	5.2	-2.3	0.5	0.5	-0.0
High cholesterol (Self-reported)	1.0	1.8	3.4	-0.2	-0.7	-1.8	-1.9
Medication: Bendroflumethiazide	2.2	3.3	7.6	0.6	-2.3	-2.7	-0.0
Medication: Paracetamol	5.2	8.0	10.2	2.1	-3.0	2.9	3.2
Medication: Lisinopril	0.7	0.9	2.1	0.2	-0.8	-1.4	0.9
Medication: Atorvastatin	0.2	0.2	0.8	-0.2	0.1	-0.9	0.2
Illnesses of father: High blood pressure	1.9	2.3	6.2	-0.5	0.1	-2.5	-1.7
Alcohol drinker status: Never	0.8	0.9	1.5	1.2	-1.2	-0.7	0.4
Ever smoked	1.2	2.2	4.0	-1.1	2.0	-0.0	-1.9
Basal metabolic rate	0.4	2.0	4.5	1.4	0.4	-2.1	-1.2
Leg fat percentage (left)	0.3	0.9	1.9	1.0	-1.4	0.3	0.9
Arm fat-free mass (left)	0.4	2.0	3.0	1.5	1.2	-1.7	-1.1
Number of operations (self-reported)	2.8	4.1	11.6	1.4	-3.4	-0.6	1.6
Average weekly beer plus cider intake	0.8	1.2	3.0	-0.3	-0.0	-1.7	-1.4
Irritability	0.7	1.2	2.3	-1.5	-0.7	-1.1	-0.9
Risk taking	0.6	0.9	1.8	-0.5	-0.9	0.7	1.3
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.1	-0.1	-1.0	-0.6	0.3
Fractured/broken bones in last 5 years	0.2	0.3	0.4	-0.3	-0.5	0.6	0.7
Age started oral contraceptive pill	0.4	0.5	1.1	0.4	0.7	1.0	0.5
Diastolic blood pressure, automated reading	0.7	2.0	5.2	0.2	-0.8	-2.3	-1.4
Ever depressed for a whole week	0.8	1.0	1.6	-1.3	-0.7	-1.2	-0.6
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.3	-0.4	-0.2	-0.4
Commuting to job workplace: Cycle	1.3	1.6	5.0	0.2	2.2	1.1	0.1
Myopia	1.2	1.7	3.3	-1.4	-0.6	-1.8	-1.1
Vascular/heart problems diagnosed by doctor	2.1	5.8	15.7	-0.7	1.7	4.0	2.0
Cholesterol lowering medication	2.2	3.2	7.2	0.7	-1.7	-2.7	-1.5
Medication: Omeprazole (e.g. Zanprol)	1.8	2.1	4.6	-2.1	-2.0	0.2	0.3
Pain experienced in last month	0.2	0.4	1.2	0.1	0.1	-0.6	-1.1
Supplements: Calcium	0.3	0.3	0.9	-0.6	0.9	-0.3	-0.1
Basal cell carcinoma (self-reported)	2.6	3.1	4.6	-1.1	-1.5	2.1	2.1
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.7	-0.4	-0.9	0.5	0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	-0.0	-0.2	0.1	-0.6
Heart disease (siblings)	1.8	2.2	4.1	1.4	-1.2	1.1	2.0
Alcohol drinker status: Previous	0.8	1.0	2.7	-1.6	-0.3	-0.4	-0.9
Pack years of smoking	0.7	1.0	1.6	-1.2	-0.5	-1.3	-0.9
Impedance of whole body	0.6	3.2	7.0	-0.6	-1.5	2.6	1.8
Leg fat mass (left)	0.2	0.6	1.4	1.2	-0.9	-0.2	0.4
Arm predicted mass (left)	0.4	2.0	3.0	1.6	1.0	-1.7	-1.2