Hub : Genes

HHIPL1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0770 0.0330 1.4e-02 0.041 0.010 0.027 0.024 0.033 8.6e-06 1.7e-02 2.6e-04 0.00062 6.4e-05
2 GTEx Adipose Subcutaneous 0.3480 0.0610 3.1e-08 0.086 NA 0.135 NA 0.131 1.6e-07 NA 3.9e-11 NA 7.2e-11
3 GTEx Breast Mammary Tissue 0.1560 0.0630 8.8e-03 -0.003 NA 0.009 NA 0.024 5.2e-01 NA 1.0e-01 NA 2.1e-02
4 GTEx Breast Mammary Tissue (Male) 0.0851 0.1048 2.7e-01 -0.010 NA -0.010 NA -0.012 6.5e-01 NA 6.2e-01 NA 8.2e-01
5 GTEx Breast Mammary Tissue (Female) 0.1655 0.0897 4.5e-02 -0.010 NA -0.002 NA -0.010 8.9e-01 NA 3.7e-01 NA 9.1e-01
6 GTEx Cells Transformed fibroblasts 0.2970 0.0550 2.3e-07 0.215 NA 0.210 NA 0.214 4.3e-16 NA 1.1e-15 NA 5.4e-16
7 METSIM Adipose 0.0394 0.0164 5.8e-03 0.002 0.010 0.008 0.009 0.006 1.6e-01 1.2e-02 1.6e-02 0.01200 3.9e-02
8 TCGA Head and Neck Squamous Cell Carcinoma 0.0462 0.0286 2.2e-03 0.019 0.022 0.002 NA 0.011 2.9e-03 1.5e-03 1.8e-01 NA 1.8e-02
9 TCGA Kidney Renal Clear Cell Carcinoma 0.0465 0.0189 5.9e-05 0.058 0.034 0.043 NA 0.046 4.4e-07 8.3e-05 1.2e-05 NA 6.1e-06
10 TCGA Kidney Renal Papillary Cell Carcinoma 0.0900 0.0400 2.4e-04 0.111 0.068 0.086 NA 0.098 6.4e-07 9.8e-05 1.2e-05 NA 3.2e-06
11 TCGA Prostate Adenocarcinoma 0.0381 0.0180 2.5e-03 0.003 0.029 0.017 NA 0.010 1.4e-01 4.6e-04 6.4e-03 NA 2.9e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.4 0.6 3.4 -0.2 0.7 -0.8 0.0 0.0 0.6 -1.9 1.2 0.0 -0.1 0.3
Bipolar Disorder or Schizophrenia 0.2 0.6 4.1 0.2 -0.2 -0.0 0.0 0.0 0.1 -2.0 -0.2 -1.0 -0.8 -0.8
Depressed Affect (Nagel 2018) 0.3 0.6 3.2 -0.0 1.1 0.8 0.0 0.0 0.3 -1.8 -0.4 0.4 0.5 -0.8
Depression (Nagel 2018) 0.5 0.7 5.9 0.6 -0.1 -0.4 0.0 0.0 0.0 -2.4 0.0 -0.4 -0.5 -1.1
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.5 -0.2 0.3 0.6 0.0 0.0 1.2 0.4 0.5 -0.2 -0.1 1.2
Neuroticism (Nagel 2018) 0.1 0.2 1.0 0.3 0.8 0.3 0.0 0.0 -0.1 -1.0 0.1 0.3 0.3 -0.1
Schizophrenia (2018) 0.3 0.6 1.6 0.4 -0.7 0.5 0.0 0.0 -0.3 -1.1 -1.0 -1.0 -0.8 -1.3
Schizophrenia vs Biploar Disorder 1.0 1.3 4.5 -1.5 -0.3 1.6 0.0 0.0 -2.1 1.4 -1.1 0.0 0.3 -1.3
Worry (Nagel 2018) 0.0 0.0 0.1 0.3 -0.1 -0.0 0.0 0.0 -0.3 -0.0 0.1 -0.3 -0.1 0.3
Alzheimer’s Disease (in mother) 0.4 0.4 1.6 -0.9 0.0 1.0 0.0 0.0 -0.1 -1.3 -0.3 0.8 0.8 0.3
Alzheimer’s Disease (in father) 0.5 0.5 1.1 -1.0 0.9 -0.3 0.0 0.0 0.8 -0.8 1.1 0.6 0.8 0.0
Alzheimer’s Disease (including proxy) 0.8 1.1 4.3 -2.1 0.9 0.5 0.0 0.0 -0.2 -1.4 0.7 1.4 1.5 0.2
Crohns Disease (2017) 0.1 0.2 0.6 0.4 -0.1 -0.3 0.0 0.0 -0.7 0.2 -0.0 -0.7 -0.8 -0.1
Irritable Bowel Disease (IBD) 0.4 0.9 3.0 0.6 -0.6 -1.7 0.0 0.0 -0.9 0.4 -0.9 -0.8 -0.9 -1.6
Ulcerative Colitis (UC) 0.4 0.8 3.7 0.4 -0.4 -1.9 0.0 0.0 -0.7 -0.0 -0.8 -0.3 -0.4 -1.9
Major Depression (MDD) 0.7 0.9 2.5 1.1 -0.7 -0.8 0.0 0.0 0.7 -1.5 -0.9 0.0 -1.6 -1.1
Reaction Time 0.1 0.2 0.5 -0.7 0.3 0.7 0.0 0.0 -0.1 0.4 -0.7 0.2 0.2 -0.4
Verbal and Numeric Reasoning (VNR) 0.3 0.8 3.8 -0.3 0.7 0.6 0.0 0.0 2.0 0.2 0.5 0.0 0.2 1.8
Breast Cancer 0.6 1.5 3.3 -1.2 1.8 0.5 0.0 0.0 0.5 -1.7 1.4 1.2 1.6 1.5
Ovarian Cancer 2.2 3.0 9.8 -2.5 1.3 2.3 0.0 0.0 -0.1 -0.1 0.7 3.0 3.1 0.6
Prostate Cancer 0.6 0.8 6.1 -0.6 -0.6 0.7 0.0 0.0 -0.6 -2.5 -0.6 0.2 -0.2 -0.8
Age at First Birth 0.7 1.0 4.6 -0.5 -0.4 2.0 0.0 0.0 -2.1 -0.2 -0.6 -0.1 0.1 -1.3
Bipolar Disorder (2011) 0.7 0.7 6.7 -0.2 0.5 -0.6 0.0 0.0 0.0 -2.6 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.5 1.7 -0.8 0.4 1.1 0.0 0.0 -0.2 1.3 -0.1 0.7 0.9 -0.1
Coronary Artery Disease (CAD) 5.7 6.8 17.7 2.6 -3.7 -1.2 0.0 0.0 -4.2 -0.8 -3.4 0.0 -3.2 -3.6
Crohns Disease (2012) 0.1 0.2 0.6 -0.8 0.5 0.2 0.0 0.0 -0.7 0.6 0.6 0.0 0.2 0.7
Mean Putamen Volume 0.1 0.1 0.6 0.3 0.4 -0.8 0.0 0.0 -0.3 0.1 0.4 -0.3 -0.1 -0.2
Fasting Glucose 0.3 0.3 2.4 -0.4 -0.2 0.1 0.0 0.0 -0.3 0.7 0.6 -0.1 -0.0 -1.6
HbA1C 0.7 0.8 3.0 -1.3 0.1 -0.0 0.0 0.0 0.9 1.7 1.2 0.4 0.1 1.2
HDL Cholesterol 0.2 0.3 0.7 -0.8 0.3 0.2 0.0 0.0 0.3 0.8 -0.5 0.6 0.6 0.5
LDL Cholesterol 2.2 3.5 10.9 2.5 -2.4 -1.5 0.0 0.0 1.5 0.6 -3.3 -2.0 -2.1 -1.7
Lupus 1.1 1.7 4.7 -1.7 0.8 0.3 0.0 0.0 1.6 -0.2 2.2 1.3 1.7 1.9
Neuroticism (2016) 0.3 0.5 2.3 -0.5 0.8 -0.0 0.0 0.0 -0.7 -1.5 -0.7 0.8 0.4 0.2
Primary Biliary Cirrhosis 0.8 1.1 2.5 -1.6 1.3 1.1 0.0 0.0 0.4 0.6 1.1 1.3 1.3 1.2
Rheumatoid Arthritis 0.2 0.3 1.6 0.7 -0.3 -1.3 0.0 0.0 0.2 0.3 0.3 -0.5 -0.2 -0.3
Schizophrenia (2014) 0.2 0.4 0.9 0.3 -0.3 0.6 0.0 0.0 -0.3 -0.9 -0.7 -0.8 -0.7 -1.0
Triglycerides 0.2 0.3 1.3 -0.2 -0.8 -0.6 0.0 0.0 0.1 -0.6 -1.1 -0.1 -0.1 -0.3
Type 2 Diabetes (T2D) (2012) 0.5 0.6 3.7 -0.2 0.9 -0.4 0.0 0.0 0.2 1.5 1.9 0.0 0.1 0.4
Ulcerative Colitis 0.3 0.5 3.0 -0.1 0.3 -1.7 0.0 0.0 -0.4 -0.6 -0.1 0.0 0.2 -1.3
Blood Eosinophil Count 0.1 1.1 3.5 1.0 -1.1 -1.9 0.0 0.0 1.2 0.2 -0.5 -1.6 -1.4 0.2
Blood Platelet Count 0.1 1.1 3.4 0.9 -1.1 0.3 0.0 0.0 1.3 1.1 -0.1 -1.8 -1.7 -0.7
Blood Red Count 0.0 0.3 1.9 0.8 0.2 -0.2 0.0 0.0 0.1 -1.4 0.8 -0.4 -0.6 0.0
Blood White Count 0.2 1.6 4.9 0.4 -0.8 -1.6 0.0 0.0 2.2 -0.4 -0.4 -2.2 -2.0 -0.0
Heel T-Score 0.3 2.6 6.6 -1.5 1.3 1.0 0.0 0.0 1.9 -0.9 1.4 2.3 2.4 2.6
BMI 0.1 0.6 3.1 0.6 0.1 0.1 0.0 0.0 1.1 1.8 0.0 -0.8 -0.7 0.3
Height 0.4 8.6 19.4 -3.1 1.9 4.0 0.0 0.0 -3.7 3.5 1.1 4.4 4.3 0.9
Waist Hip Ratio (WHR) 0.1 0.6 3.4 -1.1 0.2 1.2 0.0 0.0 -1.9 -0.1 -0.2 0.4 0.3 -0.8
Systolic Blood Pressure 2.6 12.8 31.6 3.7 -5.6 -1.4 0.0 0.0 -2.5 -2.8 -5.1 -4.0 -4.9 -3.5
Smoking Status 0.5 1.2 2.9 -1.6 1.2 -0.1 0.0 0.0 1.4 -1.4 1.7 0.6 0.9 1.3
Allergy or Eczema 0.1 0.2 0.8 -0.1 -0.9 0.3 0.0 0.0 -0.7 -0.1 -0.2 -0.2 -0.3 -0.7
Cardiovascular Disease 0.3 0.9 3.2 -0.7 0.0 1.8 0.0 0.0 -0.3 1.5 0.2 1.3 1.1 1.1
Hypothyroidism (self reported) 0.1 0.3 1.4 -0.1 0.0 -0.2 0.0 0.0 0.3 0.8 0.9 0.1 0.1 1.2
Respiratory disease 0.3 0.7 2.1 0.4 1.4 0.5 0.0 0.0 0.4 -1.4 1.2 0.7 0.9 0.6
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.6 0.0 -0.6 0.8 0.0 0.0 -0.7 -0.0 0.2 -0.0 0.2 -0.2
Lung FEV1/FVC ratio 3.3 17.0 44.4 5.1 -6.0 -1.9 0.0 0.0 0.6 -0.3 -5.3 -6.2 -6.7 -3.2
Lung FVC 0.4 1.8 4.4 -1.4 1.9 -0.6 0.0 0.0 1.1 -0.0 1.9 1.3 1.7 2.1
Neuroticism 0.1 0.2 0.6 0.3 0.1 -0.4 0.0 0.0 0.6 -0.8 -0.5 -0.6 -0.5 -0.2
Chronotype (morning person) 0.0 0.1 0.6 0.0 -0.1 -0.1 0.0 0.0 -0.8 -0.3 -0.1 0.1 -0.1 -0.1
Hair Pigment 0.0 0.7 2.7 1.2 -0.6 0.9 0.0 0.0 0.7 1.6 -1.0 -0.6 -0.6 -0.3
Tanning 0.0 0.5 2.5 0.4 -0.2 -1.6 0.0 0.0 0.6 1.3 0.2 -0.2 -0.1 0.5
Hand grip strength (left) 0.5 1.2 3.0 1.7 -1.3 -1.0 0.0 0.0 -1.1 0.4 -0.3 -1.5 -1.7 -1.2
Number of treatments/medications taken 0.5 1.0 3.8 -0.8 1.0 0.4 0.0 0.0 0.1 1.9 1.6 1.0 1.2 0.4
Average weekly spirits intake 0.1 0.2 0.6 -0.7 0.2 0.3 0.0 0.0 0.7 -0.3 -0.3 0.1 0.2 0.6
Sensitivity / hurt feelings 0.6 1.1 5.5 -0.6 1.0 -0.0 0.0 0.0 0.4 -2.3 1.1 0.9 0.9 1.4
Frequency of depressed mood in last 2 weeks 0.5 0.6 3.9 0.8 -0.6 0.0 0.0 0.0 -0.6 -2.0 -0.7 -0.5 -0.7 -0.7
Hearing difficulty/problems: Yes 0.2 0.3 1.2 0.4 0.7 0.2 0.0 0.0 0.6 -0.5 1.1 -0.3 -0.0 -0.2
Relative age of first facial hair 0.3 0.6 3.1 -0.6 -0.6 1.4 0.0 0.0 -0.4 -1.8 -0.7 -0.1 0.1 0.4
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 1.6 0.3 0.2 -0.1 0.0 0.0 0.7 -0.2 -1.3 -0.2 0.0 0.2
Ever used hormone-replacement therapy (HRT) 0.7 0.9 3.6 0.8 -0.8 1.5 0.0 0.0 -0.9 0.5 -0.9 -0.8 -0.7 -1.9
Ever had hysterectomy (womb removed) 1.6 1.8 3.6 -1.9 1.8 1.4 0.0 0.0 0.0 1.3 1.7 1.7 1.9 0.5
Systolic blood pressure, automated reading 3.6 10.3 24.2 4.2 -4.9 -1.9 0.0 0.0 -1.0 -2.7 -3.9 -3.9 -4.6 -2.9
Eye problems/disorders: Diabetes related eye disease 1.5 1.7 3.6 -0.6 1.3 1.7 0.0 0.0 0.3 0.7 1.9 1.6 1.8 1.9
Angina 0.5 0.7 3.3 0.7 -0.9 0.9 0.0 0.0 -1.8 -0.8 -0.7 -0.4 -0.7 -0.0
Medication for hormone replacement therapy 0.6 0.6 1.9 -0.7 0.9 1.0 0.0 0.0 -1.4 -0.5 1.2 0.8 0.6 -0.4
Vitamin and mineral supplements 0.5 0.7 4.4 -0.3 0.1 1.5 0.0 0.0 -0.7 2.1 0.8 0.2 0.4 0.1
Supplements: Zinc 0.4 0.4 1.1 0.4 -0.9 -0.2 0.0 0.0 0.4 -0.8 -1.0 -1.0 -1.0 -0.0
Medication: Co-codamol 3.4 3.9 9.3 3.1 -2.6 -2.1 0.0 0.0 0.5 -0.6 -1.8 -2.5 -2.7 -2.3
Medication: Metformin 0.1 0.1 0.3 0.2 -0.1 0.6 0.0 0.0 0.3 -0.0 0.4 -0.4 -0.1 0.6
Diabetes (father) 0.3 0.4 1.6 -0.4 1.3 0.1 0.0 0.0 -0.9 1.2 0.5 0.4 0.1 0.2
Diabetes (mother) 0.2 0.3 2.4 0.7 0.2 0.0 0.0 0.0 0.3 -0.7 -0.0 -0.1 0.2 -1.6
Severe depression (siblings) 0.4 0.4 2.4 0.2 0.2 -0.3 0.0 0.0 1.1 -1.5 0.9 -0.0 0.1 -0.4
Pack years adult smoking proportion 0.8 1.1 3.6 -1.9 0.9 0.3 0.0 0.0 -0.6 0.3 1.1 1.7 1.6 1.0
Impedance of leg (right) 0.5 2.4 7.9 -1.6 0.5 2.8 0.0 0.0 -2.5 -0.3 0.6 2.3 1.8 0.7
Leg fat-free mass (left) 0.1 0.7 6.2 0.6 0.6 -0.4 0.0 0.0 0.5 2.5 0.7 -0.3 -0.0 0.2
Trunk fat percentage 0.2 0.9 8.2 -0.2 0.0 1.4 0.0 0.0 0.4 2.9 0.3 -0.0 -0.1 0.2
Hand grip strength (right) 0.3 0.8 2.8 1.4 -0.6 -1.7 0.0 0.0 -0.3 -0.4 0.3 -1.2 -1.3 -0.6
Townsend deprivation index at recruitment 0.6 0.8 1.8 -1.2 1.2 0.7 0.0 0.0 -0.3 -0.3 0.9 1.1 1.4 1.2
Current tobacco smoking 0.5 0.9 3.2 -1.1 0.6 0.9 0.0 0.0 1.5 0.5 0.4 0.8 0.7 1.8
Average weekly fortified wine intake 1.0 1.1 2.9 1.4 -0.7 -1.2 0.0 0.0 1.4 -0.1 -0.9 -1.7 -1.6 -0.4
Maternal smoking around birth 1.0 1.5 6.2 -0.8 2.5 0.9 0.0 0.0 0.1 -0.5 1.8 1.3 1.4 1.3
Fed-up feelings 0.3 0.6 3.5 -0.2 0.1 -0.3 0.0 0.0 -0.8 -1.9 -0.7 -0.0 -0.1 -1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 7.5 0.2 -0.2 0.2 0.0 0.0 0.6 -2.7 -0.8 -0.2 -0.4 -0.9
Relative age voice broke 0.6 0.9 4.4 -1.1 0.0 2.1 0.0 0.0 -1.1 -1.0 0.1 0.8 1.1 0.1
Taking other prescription medications 0.3 0.4 1.7 0.1 0.5 -0.7 0.0 0.0 0.5 1.0 1.3 0.4 0.7 0.6
Age when periods started (menarche) 0.7 1.6 6.3 -1.1 2.5 0.8 0.0 0.0 -1.5 -0.6 1.7 1.4 1.3 0.4
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.9 -0.4 0.5 1.4 0.0 0.0 -0.1 0.5 -0.2 0.6 0.8 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.6 6.4 -2.3 1.6 2.3 0.0 0.0 0.2 0.1 1.1 2.5 2.4 1.4
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 1.4 1.1 -0.8 1.0 0.0 0.0 0.8 -1.1 -1.2 -0.2 -0.4 0.1
Qualifications: CSEs or equivalent 0.6 0.8 2.3 -1.3 0.5 0.8 0.0 0.0 -1.5 0.9 0.4 1.3 1.3 -0.1
Serious illness, injury or assault to yourself 0.2 0.2 1.3 -0.3 0.3 1.2 0.0 0.0 0.7 -0.1 0.4 0.5 0.5 0.1
High blood pressure 0.3 1.0 4.3 -0.7 -0.5 2.1 0.0 0.0 -0.0 1.6 0.2 1.0 1.0 1.0
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.3 0.1 -0.4 -0.0 0.0 0.0 -0.5 -0.5 0.5 -0.1 -0.3 -0.5
Multivitamins +/- minerals 0.3 0.4 2.6 -0.3 0.4 -0.3 0.0 0.0 0.7 -1.6 -0.5 0.7 0.2 0.3
Stomach or abdominal pain in last month 1.6 2.0 4.8 -1.5 2.0 1.5 0.0 0.0 1.2 0.8 1.0 1.3 1.8 2.2
Supplements: Glucosamine 0.2 0.3 1.1 -0.5 0.5 -0.2 0.0 0.0 1.1 -0.9 0.4 0.3 0.5 0.4
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.9 -0.2 0.9 0.5 0.0 0.0 0.5 0.4 0.8 0.0 0.4 -0.5
Medication: Atenolol 0.9 1.2 4.8 -0.5 0.8 2.2 0.0 0.0 -0.1 0.9 0.6 1.3 1.3 1.7
Medication: Levothyroxine sodium 0.7 1.1 5.2 -0.3 0.3 0.6 0.0 0.0 1.3 2.3 0.3 -0.3 -0.4 2.1
Sitting height 0.1 0.5 1.7 1.0 -0.8 -1.1 0.0 0.0 -0.6 -0.1 -1.3 -0.3 -0.5 -0.7
Chronic bronchitis/emphysema (father) 1.0 1.2 3.8 -0.4 1.8 0.5 0.0 0.0 -0.6 -0.2 1.9 1.4 1.7 0.7
High blood pressure (mother) 0.4 0.6 1.7 0.6 -1.2 0.4 0.0 0.0 -0.3 -0.0 0.0 -1.3 -1.3 -1.0
Body mass index (BMI) 0.2 0.7 4.7 0.4 0.1 0.2 0.0 0.0 1.3 2.2 0.5 -0.7 -0.5 0.2
Impedance of leg (left) 0.4 2.0 5.9 -1.6 0.6 2.4 0.0 0.0 -2.2 -0.5 0.6 2.1 1.5 0.7
Leg predicted mass (left) 0.1 0.7 6.1 0.6 0.7 -0.4 0.0 0.0 0.6 2.5 0.8 -0.2 0.0 0.3
Trunk fat mass 0.3 1.1 9.6 -0.4 0.4 1.2 0.0 0.0 0.4 3.1 0.8 0.3 0.3 0.5
Waist circumference 0.4 1.4 7.5 -0.7 1.2 1.3 0.0 0.0 0.6 2.7 1.5 0.5 0.7 0.8
Number of incorrect matches in round 0.4 0.6 3.6 0.1 0.2 -0.7 0.0 0.0 -1.9 0.6 0.2 -0.8 -1.0 -0.5
Past tobacco smoking 0.4 0.8 6.8 0.1 0.0 0.6 0.0 0.0 -1.1 2.6 -0.0 0.4 0.1 -0.2
Alcohol usually taken with meals 0.3 0.4 2.2 -0.4 0.6 -1.5 0.0 0.0 0.1 0.8 0.7 -0.7 -0.6 0.2
Nervous feelings 0.6 1.2 3.3 -1.2 0.5 1.8 0.0 0.0 -1.4 -0.2 -0.1 1.4 1.2 1.5
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 1.0 -0.2 -0.1 -0.1 0.0 0.0 -0.3 -0.8 -1.0 0.4 0.2 -0.2
Hearing difficulty/problems with background noise 0.2 0.3 0.8 -0.4 0.8 0.6 0.0 0.0 0.3 -0.9 0.9 -0.0 0.3 -0.3
Hair/balding pattern: Pattern 2 0.5 0.7 1.6 -1.3 1.3 0.2 0.0 0.0 1.2 0.0 -0.1 0.9 1.1 0.6
Had menopause 0.4 0.5 1.8 1.2 -0.9 -0.2 0.0 0.0 -0.1 -0.1 -1.2 -0.4 -0.3 -1.3
Had other major operations 0.1 0.1 0.7 -0.0 0.1 -0.2 0.0 0.0 0.7 0.9 -0.1 -0.5 -0.1 -0.1
Forced vital capacity (FVC) 0.6 2.3 5.6 -1.6 1.9 -0.2 0.0 0.0 -0.9 0.6 1.6 2.4 2.3 2.2
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 5.2 -2.3 0.9 1.1 0.0 0.0 0.5 -0.3 0.8 1.8 1.6 1.2
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 2.1 -1.4 0.3 0.7 0.0 0.0 -0.1 -1.2 -0.1 0.5 0.4 -0.4
Qualifications: None of the above 0.4 0.8 1.6 -1.2 0.8 1.1 0.0 0.0 -0.7 -0.9 1.2 1.1 1.3 0.3
Financial difficulties in last 2 years 0.7 0.9 2.1 -1.5 1.2 1.2 0.0 0.0 -1.4 -0.2 0.2 1.4 1.1 0.2
Mouth/teeth dental problems 0.5 0.8 2.1 1.5 -1.2 -0.5 0.0 0.0 -0.6 0.9 0.1 -1.2 -1.2 -0.9
Heart attack 1.3 1.6 11.3 -0.3 -0.2 1.5 0.0 0.0 -3.4 -0.8 -0.3 0.4 0.3 -1.8
Allergy 0.2 0.4 1.7 0.6 -0.5 -0.6 0.0 0.0 0.8 0.3 -1.3 -0.9 -0.8 -0.4
Pain all over the body in last month 0.3 0.3 1.3 -0.3 0.3 1.1 0.0 0.0 0.1 -0.6 0.6 0.6 0.6 -0.4
Diabetes (self-reported) 0.1 0.2 0.6 -0.1 -0.8 0.2 0.0 0.0 -0.8 0.5 0.5 -0.5 -0.1 -0.4
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.2 -0.8 0.5 -0.4 0.0 0.0 -0.3 0.2 1.1 0.4 0.3 0.7
Medication: Ramipril 0.8 1.1 4.5 -1.2 0.4 1.8 0.0 0.0 -2.1 1.0 0.5 0.7 0.6 -0.5
Medication: Simvastatin 0.5 0.8 2.9 1.7 -1.3 -0.6 0.0 0.0 0.6 0.6 -0.0 -1.1 -1.0 -1.0
Fluid intelligence score 0.4 0.8 4.5 -0.1 0.3 1.2 0.0 0.0 2.1 -0.1 0.4 -0.4 -0.1 1.8
Illnesses of siblings 0.3 0.4 1.3 -0.8 0.5 0.5 0.0 0.0 -0.8 -0.6 0.1 1.1 1.1 -0.2
Neuroticism score 0.1 0.2 1.7 0.3 -0.2 -0.1 0.0 0.0 0.2 -1.3 -0.5 -0.3 -0.3 0.2
Weight 0.2 1.2 10.0 -0.1 0.9 0.7 0.0 0.0 0.4 3.2 1.0 0.4 0.5 0.5
Impedance of arm (right) 0.3 1.3 4.5 0.1 -1.4 1.3 0.0 0.0 -1.6 -0.6 -2.1 -0.0 -0.4 -1.6
Arm fat percentage (right) 0.2 0.9 6.7 0.4 -0.6 0.7 0.0 0.0 1.1 2.6 -0.3 -0.8 -0.8 -0.3
Trunk fat-free mass 0.2 1.1 6.2 0.2 1.3 -0.5 0.0 0.0 0.5 2.5 1.4 0.5 0.7 0.9
Hip circumference 0.3 1.2 10.0 -0.3 0.6 0.4 0.0 0.0 0.8 3.2 1.3 0.3 0.4 0.4
Time employed in main current job 0.5 0.6 1.9 -1.2 0.0 -0.7 0.0 0.0 -1.4 1.3 0.4 0.4 0.2 0.9
Alcohol intake versus 10 years previously 0.3 0.5 1.3 -0.8 0.4 0.7 0.0 0.0 0.8 1.1 -0.0 0.6 0.7 1.1
Father’s age at death 0.9 1.2 3.4 -0.8 1.4 -0.9 0.0 0.0 1.8 1.3 1.8 0.5 0.9 1.0
Worrier / anxious feelings 0.4 0.7 2.6 -0.9 0.4 0.4 0.0 0.0 -0.3 0.5 0.8 1.1 1.1 1.6
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 1.4 -0.7 0.0 1.2 0.0 0.0 0.6 -1.0 -0.5 0.3 0.2 0.9
Falls in the last year 0.3 0.4 2.5 1.0 -0.4 0.3 0.0 0.0 0.2 0.4 -1.6 -0.7 -0.5 -0.3
Hair/balding pattern: Pattern 3 0.3 0.5 1.9 -1.0 -0.0 0.9 0.0 0.0 -1.4 0.5 -0.2 0.2 0.2 -1.2
Number of live births 2.4 3.4 6.7 -2.1 2.4 2.2 0.0 0.0 -0.5 0.3 2.6 2.2 2.4 2.2
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 1.0 0.4 -0.2 -1.0 0.0 0.0 -0.3 0.4 -0.3 -0.0 -0.2 0.9
Pulse rate 0.9 1.5 2.9 -1.7 1.4 1.4 0.0 0.0 1.4 -0.9 0.5 1.5 1.3 1.7
Happiness 0.5 0.6 4.1 -0.6 -0.6 -0.3 0.0 0.0 0.5 -2.0 -0.7 0.1 -0.1 -0.8
Noisy workplace 0.6 0.8 2.1 1.4 -0.7 -0.9 0.0 0.0 -0.1 -1.0 -1.2 -1.2 -1.1 -0.6
Qualifications: A levels/AS levels or equivalent 0.1 0.2 1.2 0.4 -0.2 0.0 0.0 0.0 0.7 0.3 -1.1 -0.1 -0.3 0.3
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.3 4.2 1.4 -1.0 -0.9 0.0 0.0 0.5 -1.6 -0.4 -2.1 -1.8 -0.8
Mouth/teeth dental problems: Dentures 0.1 0.1 0.4 0.5 0.6 -0.3 0.0 0.0 0.3 -0.2 0.3 -0.4 -0.1 -0.1
Asthma 0.4 0.8 1.9 -0.7 0.7 0.7 0.0 0.0 -1.1 -0.9 1.3 1.4 1.4 0.4
Medication: Ibuprofen (e.g. Nurofen) 3.3 4.1 11.1 -3.3 2.6 1.1 0.0 0.0 0.5 -0.6 2.2 2.6 2.7 2.5
Medication: Cholesterol lowering 0.2 0.2 0.7 0.5 -0.8 0.6 0.0 0.0 -0.5 -0.2 0.3 -0.6 -0.6 -0.3
Depression (self-reported) 0.9 1.1 4.6 0.9 0.3 -1.8 0.0 0.0 -1.0 -0.8 -0.4 -0.6 -0.8 -2.2
Medication: Lansoprazole 0.1 0.1 0.3 -0.2 0.4 -0.4 0.0 0.0 0.2 0.2 -0.4 -0.1 0.1 -0.5
Prospective memory result 1.5 1.8 5.7 2.4 -1.7 -1.8 0.0 0.0 -0.5 -0.5 -1.5 -0.9 -1.4 -1.6
Lung cancer (father) 0.5 0.6 1.3 -0.9 0.6 1.0 0.0 0.0 -0.8 0.5 1.1 1.0 1.0 0.1
Illnesses of mother 0.7 0.9 4.5 -0.7 1.0 -0.8 0.0 0.0 2.1 0.9 0.5 0.2 0.5 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 2.9 0.2 0.0 -1.1 0.0 0.0 0.6 0.6 -0.1 0.1 0.0 1.7
Pulse wave Arterial Stiffness index 0.9 1.1 3.3 -1.2 0.5 0.8 0.0 0.0 0.7 -1.8 0.3 1.4 1.3 1.6
Impedance of arm (left) 0.2 1.0 3.3 0.3 -1.1 1.3 0.0 0.0 -1.4 -0.2 -1.8 -0.3 -0.5 -1.5
Arm fat mass (right) 0.2 0.9 8.5 0.2 -0.0 0.5 0.0 0.0 1.0 2.9 0.3 -0.5 -0.4 0.1
Trunk predicted mass 0.2 1.0 6.0 0.2 1.2 -0.5 0.0 0.0 0.4 2.5 1.4 0.5 0.7 0.9
Standing height 0.2 2.1 7.4 -0.7 1.7 0.9 0.0 0.0 -1.8 2.7 0.9 2.0 1.9 0.7
Length of working week for main job 0.1 0.1 0.5 0.0 0.1 -0.3 0.0 0.0 0.4 0.6 0.1 -0.4 -0.5 0.7
Exposure to tobacco smoke at home 1.8 2.0 5.0 -1.8 1.7 2.2 0.0 0.0 -1.7 -0.2 1.4 1.5 1.9 0.4
Breastfed as a baby 1.4 1.7 4.8 -2.2 1.9 1.0 0.0 0.0 -1.2 0.2 1.5 1.6 1.7 0.7
Tense / ‘highly strung’ 0.2 0.3 1.3 0.6 0.2 0.6 0.0 0.0 0.5 -1.1 0.2 0.2 0.1 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 4.2 0.5 0.2 -0.5 0.0 0.0 1.3 -2.1 -0.2 -0.7 -0.5 -0.5
Hair/balding pattern: Pattern 4 2.2 5.2 11.7 3.3 -2.5 -3.0 0.0 0.0 0.1 -0.9 -1.7 -3.1 -3.4 -2.6
Birth weight of first child 1.6 2.9 6.5 -1.1 2.5 1.6 0.0 0.0 1.9 2.2 1.7 1.4 1.6 2.4
Peak expiratory flow (PEF) 0.4 1.0 2.9 1.1 -1.3 -1.7 0.0 0.0 -1.1 -0.2 -0.8 -1.0 -1.2 -0.8
Pulse wave reflection index 0.9 1.2 2.9 -0.6 1.1 0.6 0.0 0.0 1.3 -1.7 1.4 1.1 1.4 1.2
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.8 -1.3 0.8 1.0 0.0 0.0 -0.6 -0.3 -0.3 1.4 0.9 1.2
Loud music exposure frequency 0.8 0.9 3.3 1.4 -1.0 -0.8 0.0 0.0 1.8 -1.7 -0.1 -0.2 -0.2 -0.6
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.5 1.1 -0.5 -0.9 0.0 0.0 0.2 -0.6 -0.8 -1.2 -1.2 -1.0
Mouth/teeth dental problems: Bleeding gums 1.6 2.1 5.0 -1.9 1.3 1.6 0.0 0.0 -1.2 -1.7 0.5 2.2 2.1 0.9
Blood clot in the leg (DVT) 1.0 1.3 4.8 -0.9 1.4 -0.7 0.0 0.0 0.5 -0.3 2.2 0.9 1.1 1.8
Medication: Paracetamol 2.9 4.8 10.5 -2.3 3.2 0.9 0.0 0.0 2.4 1.1 3.2 2.3 2.9 2.5
Headache pain in last month 3.4 5.8 14.7 -2.2 3.1 0.5 0.0 0.0 3.7 -0.1 3.4 1.8 2.4 3.8
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 2.2 0.5 0.2 -1.5 0.0 0.0 1.3 -0.2 -1.0 -0.6 -0.7 0.0
Glaucoma (self-reported) 1.2 1.4 2.6 1.3 -0.8 -1.4 0.0 0.0 -1.6 -0.8 -1.6 -1.3 -1.2 -1.5
Gout (self-reported) 0.9 1.3 3.7 -1.9 1.0 1.3 0.0 0.0 -0.4 0.7 1.2 1.4 1.8 0.2
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 2.3 0.4 -0.7 0.2 0.0 0.0 1.3 1.5 0.4 -0.7 -0.6 0.9
Medication: Amlodipine 0.6 0.9 3.5 -0.2 -0.2 1.0 0.0 0.0 0.5 -0.3 1.1 1.5 1.3 1.9
Medication: Ventolin 100micrograms inhaler 0.8 1.0 5.7 -0.3 0.3 0.7 0.0 0.0 -2.4 -1.0 0.1 1.5 1.2 -0.3
Birth weight 0.2 0.4 1.8 -0.8 1.3 0.3 0.0 0.0 0.4 0.4 0.7 0.7 1.0 0.2
Chronic bronchitis/emphysema (mother) 0.4 0.5 2.4 -0.6 0.5 -0.3 0.0 0.0 -0.3 0.7 0.6 0.9 0.5 1.6
High blood pressure (siblings) 0.4 0.6 1.9 1.2 -0.2 -0.1 0.0 0.0 1.4 0.7 -1.1 -0.6 -0.8 0.6
Forced vital capacity (FVC), Best measure 0.6 2.1 6.9 -1.3 1.8 -0.8 0.0 0.0 0.6 0.2 1.5 1.9 2.0 2.6
Body fat percentage 0.2 1.0 8.1 -0.2 0.1 1.4 0.0 0.0 0.4 2.8 0.4 0.0 -0.0 0.2
Leg fat percentage (right) 0.2 0.8 4.6 -0.5 0.2 1.5 0.0 0.0 0.3 2.2 0.9 0.6 0.4 0.5
Arm fat-free mass (right) 0.3 1.7 6.1 -0.4 1.8 0.1 0.0 0.0 0.1 2.5 2.2 1.1 1.3 1.4
Exposure to tobacco smoke outside home 0.2 0.2 0.8 -0.4 -0.5 0.2 0.0 0.0 -0.6 -0.3 -0.9 -0.5 -0.6 0.3
Comparative body size at age 10 0.2 0.5 1.9 0.3 -0.8 -1.4 0.0 0.0 0.8 0.5 -0.8 -0.9 -0.7 -0.2
Number of full brothers 2.3 2.9 7.2 -2.7 1.5 1.9 0.0 0.0 -0.9 1.0 1.5 2.3 2.2 1.9
Worry too long after embarrassment 0.3 0.4 1.2 -0.0 -1.1 -0.8 0.0 0.0 0.5 -0.5 -0.9 -0.8 -1.0 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.5 0.7 -0.2 -0.6 0.0 0.0 0.5 -0.4 -0.3 -0.2 -0.5 0.3
Wheeze or whistling in the chest in last year 1.0 1.7 4.6 -1.1 1.2 0.8 0.0 0.0 -1.1 -1.1 2.1 2.0 2.2 0.3
Number of children fathered 0.3 0.3 1.2 0.6 0.4 -0.8 0.0 0.0 1.1 -0.3 -0.2 -0.7 -0.4 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 2.5 0.5 -0.0 1.6 0.0 0.0 0.1 0.2 0.2 -0.1 -0.0 1.0
Age at first live birth 0.5 0.9 6.2 -0.2 0.7 -0.3 0.0 0.0 -0.1 2.5 0.4 -1.1 -0.9 -1.0
Pulse wave peak to peak time 0.9 1.0 5.1 1.0 -0.3 -0.7 0.0 0.0 -0.7 2.2 -0.0 -1.2 -1.1 -1.3
Health satisfaction 0.1 0.1 0.4 -0.0 -0.5 0.1 0.0 0.0 0.7 -0.0 0.2 -0.1 -0.1 0.0
Shortness of breath walking on level ground 0.7 0.8 2.9 -0.2 0.4 1.7 0.0 0.0 -0.2 1.2 1.2 1.0 0.9 1.2
Qualifications: College or University degree 0.5 1.6 3.8 1.7 -0.9 -1.2 0.0 0.0 1.9 -0.3 -1.2 -1.9 -1.8 -0.3
Eye problems/disorders: None of the above 0.3 0.3 1.5 -1.2 -0.1 0.0 0.0 0.0 -0.7 0.8 0.1 0.8 0.6 0.5
Mouth/teeth dental problems: Loose teeth 0.4 0.5 2.6 -0.7 -0.4 1.6 0.0 0.0 -0.4 0.4 -1.1 -0.2 0.1 -0.5
Emphysema/chronic bronchitis 1.3 1.5 4.8 -1.5 1.8 0.6 0.0 0.0 -0.3 0.5 1.1 2.2 2.2 0.1
Medication for pain relief, constipation, heartburn 2.0 3.4 7.0 1.9 -2.4 -1.4 0.0 0.0 -2.6 -1.3 -2.4 -1.4 -1.8 -2.6
Neck or shoulder pain in last month 0.2 0.3 1.2 -0.5 0.6 -0.5 0.0 0.0 0.5 -0.4 0.1 0.5 0.4 1.1
Medication: Blood pressure 0.3 0.5 1.7 -0.7 -0.7 1.2 0.0 0.0 -1.3 0.4 1.0 0.5 0.5 -0.0
Angina (self-reported) 0.4 0.5 3.0 0.6 -0.8 1.0 0.0 0.0 -1.7 -0.8 -0.5 -0.2 -0.5 -0.0
Migraine (self-reported) 3.0 3.7 11.0 -1.4 2.8 -0.1 0.0 0.0 3.3 -0.8 2.1 1.7 2.2 2.7
Medication: Ibuprofen 4.2 5.1 12.7 -3.6 2.7 1.6 0.0 0.0 -0.2 -0.6 2.6 3.1 3.0 2.7
Medication: Allopurinol 0.7 0.9 3.5 -1.9 1.0 0.7 0.0 0.0 0.1 0.8 1.5 0.8 1.2 0.2
Medication: Omeprazole 0.2 0.3 1.1 -0.1 0.1 -1.1 0.0 0.0 0.8 0.6 0.6 -0.1 -0.0 0.5
Medication: Seretide 50 evohaler 0.2 0.2 0.7 -0.5 0.1 0.1 0.0 0.0 0.3 0.1 0.4 0.8 0.8 0.7
Mean time to correctly identify matches 0.1 0.3 0.7 -0.8 0.3 0.8 0.0 0.0 -0.0 0.9 -0.6 0.2 0.2 -0.5
Heart disease (mother) 0.9 1.1 5.9 0.1 -0.5 1.7 0.0 0.0 -2.4 0.3 -0.4 -0.5 -0.4 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 2.6 0.5 -0.6 0.0 0.0 0.0 0.4 -1.6 0.8 0.1 0.2 0.2
Whole body fat mass 0.3 1.1 9.7 -0.3 0.3 1.2 0.0 0.0 0.1 3.1 0.8 0.3 0.3 0.5
Leg fat mass (right) 0.3 1.0 6.9 -0.4 0.5 1.3 0.0 0.0 0.2 2.6 1.1 0.6 0.6 0.6
Arm predicted mass (right) 0.5 2.3 6.6 -0.6 2.2 0.3 0.0 0.0 0.4 2.3 2.6 1.4 1.7 1.8
Pulse rate, automated reading 0.1 0.3 1.0 -0.0 0.7 0.3 0.0 0.0 1.0 0.7 0.3 -0.4 -0.3 -0.8
Alcohol intake frequency. 0.3 0.6 3.1 0.7 -0.1 -0.6 0.0 0.0 1.3 -0.4 1.8 0.3 0.4 0.7
Comparative height size at age 10 1.1 5.8 16.1 -2.2 2.5 1.5 0.0 0.0 -1.3 4.0 2.4 3.5 3.4 1.7
Number of full sisters 1.0 1.2 3.3 -1.6 1.8 0.9 0.0 0.0 0.1 0.7 1.8 0.1 0.4 1.6
Suffer from ‘nerves’ 0.1 0.2 1.0 -0.2 -0.7 -0.3 0.0 0.0 -1.0 -0.9 -0.4 0.2 0.1 0.0
Overall health rating 0.1 0.3 1.4 -0.7 -0.5 1.2 0.0 0.0 -0.1 -0.0 -0.2 0.7 0.9 0.0
Chest pain or discomfort 0.5 0.7 1.5 -1.0 1.2 0.7 0.0 0.0 -0.7 -1.0 0.6 1.0 1.1 0.5
Had major operations 0.9 1.0 3.3 1.8 -1.3 -1.3 0.0 0.0 -0.5 0.3 -0.3 -1.1 -1.4 -0.8
Age at last live birth 0.3 0.4 2.4 -0.7 0.8 -0.1 0.0 0.0 -0.5 1.5 0.8 -0.5 -0.4 0.1
Family relationship satisfaction 0.6 0.8 5.5 -0.0 -0.8 -1.1 0.0 0.0 0.5 -2.4 -0.6 -0.4 -0.6 -0.4
Leg pain on walking 0.1 0.1 0.4 0.1 0.6 -0.3 0.0 0.0 -0.4 -0.1 0.5 0.2 0.1 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 1.0 0.2 1.0 0.2 0.0 0.0 0.3 -0.3 0.4 0.6 0.6 0.6
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.4 1.2 -0.9 -0.2 0.0 0.0 -0.5 0.0 -1.2 -0.7 -0.9 -0.5
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.2 -0.0 -0.0 -0.6 0.0 0.0 -1.1 0.3 0.7 0.8 0.7 -0.8
Medication: Aspirin 0.2 0.3 2.6 -0.4 -0.1 1.6 0.0 0.0 -0.5 0.1 0.2 0.2 0.2 0.2
Supplements: Vitamin C 0.5 0.6 2.7 0.3 -0.7 -1.6 0.0 0.0 -0.9 -1.5 -0.0 -0.4 -0.5 -0.4
Knee pain experienced in last month 0.6 0.9 2.6 -0.6 0.8 1.3 0.0 0.0 0.7 -0.3 0.6 1.6 1.6 1.3
Hypertension (Self-reported) 0.4 1.0 4.7 -0.5 -0.2 2.2 0.0 0.0 0.1 1.2 0.3 1.2 1.1 1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.6 -0.6 0.8 -1.2 0.0 0.0 1.2 -0.4 0.1 0.3 0.3 0.3
Illnesses of father: Heart disease 3.1 4.3 8.0 1.4 -2.2 -0.0 0.0 0.0 -2.5 -2.8 -2.7 -2.2 -2.6 -2.6
Illnesses of siblings: Diabetes 0.9 1.1 3.5 0.6 -0.7 -1.1 0.0 0.0 0.4 -1.9 -1.5 -1.4 -1.4 -0.4
Smoking status: Previous 0.2 0.4 3.3 -0.2 -0.1 -0.3 0.0 0.0 -0.0 -1.8 0.2 -0.6 -0.3 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 5.7 -0.5 0.8 2.3 0.0 0.0 -0.2 1.5 0.4 1.3 1.0 2.4
Whole body fat-free mass 0.2 1.1 6.5 0.1 1.3 -0.3 0.0 0.0 0.5 2.5 1.4 0.4 0.7 0.9
Leg fat-free mass (right) 0.1 0.7 4.9 0.5 0.9 -0.6 0.0 0.0 0.6 2.2 0.7 -0.3 -0.0 0.4
Arm fat percentage (left) 0.2 0.9 6.9 0.2 -0.2 1.0 0.0 0.0 1.1 2.6 0.1 -0.5 -0.4 0.0
Average weekly red wine intake 0.3 0.4 4.1 -0.2 -0.7 0.0 0.0 0.0 -2.0 0.1 0.1 0.2 -0.1 -0.3
Handedness (chirality/laterality): Left-handed 0.7 0.8 2.6 -1.6 -0.3 1.4 0.0 0.0 -1.5 -1.2 0.5 0.7 0.4 -0.3
Mood swings 0.6 1.0 3.6 -0.7 1.0 1.9 0.0 0.0 0.3 -1.6 -0.3 1.3 1.2 0.5
Loneliness, isolation 0.6 0.8 3.7 0.1 -0.6 -0.2 0.0 0.0 -1.5 -1.9 -1.1 0.1 -0.2 -1.3
Long-standing illness, disability or infirmity 0.2 0.3 1.4 1.2 -0.4 -0.0 0.0 0.0 0.5 0.8 -0.1 -0.8 -0.6 -0.1
Ever had bowel cancer screening 0.5 0.6 1.7 -0.1 0.3 1.3 0.0 0.0 1.0 1.3 1.1 0.4 0.5 0.9
Diabetes diagnosed by doctor 0.1 0.2 0.8 0.4 -0.9 0.4 0.0 0.0 -0.4 0.7 0.2 -0.6 -0.3 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 1.1 -0.8 0.0 0.4 0.0 0.0 -0.8 -1.0 0.1 0.2 0.2 0.0
Friendships satisfaction 0.3 0.4 2.0 -0.9 -0.2 0.5 0.0 0.0 0.2 -1.4 -0.6 0.5 0.0 0.7
Qualifications: nursing, teaching 0.1 0.1 0.3 -0.5 -0.3 -0.6 0.0 0.0 0.5 -0.1 -0.3 -0.2 0.0 -0.5
Commuting to job workplace: Walk 1.9 2.1 5.7 -2.4 0.8 1.1 0.0 0.0 -0.8 -0.7 1.9 2.1 1.8 1.7
Eye problems/disorders: Cataract 0.3 0.3 0.8 -0.4 0.8 0.9 0.0 0.0 0.1 -0.9 0.7 0.6 0.8 -0.2
Mouth/teeth dental problems: Mouth ulcers 1.8 2.8 8.8 -2.2 2.3 0.1 0.0 0.0 1.6 0.0 1.1 2.2 2.0 3.0
Medication for cholesterol 0.3 0.5 3.5 -0.2 -0.1 -1.2 0.0 0.0 -0.2 -1.9 -0.0 -0.2 -0.3 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 1.1 0.4 0.3 -0.6 0.0 0.0 1.1 0.2 0.0 -0.9 -0.6 -0.1
Back pain experienced in last month 0.6 0.8 3.6 1.3 -0.4 -1.0 0.0 0.0 1.9 -0.0 -0.2 -0.7 -0.9 1.3
Mineral and other dietary supplements 0.5 0.6 2.8 -0.7 0.8 0.4 0.0 0.0 -1.7 0.4 0.8 0.9 0.9 -0.1
Breast cancer (self-reported) 1.5 1.7 4.5 -1.8 1.0 2.0 0.0 0.0 -0.2 -0.4 0.7 2.1 1.9 1.5
Asthma (self-reported) 0.3 0.6 1.9 -0.3 0.4 0.3 0.0 0.0 -1.4 -1.0 1.1 1.1 1.1 -0.0
Osteoporosis (self-reported) 0.7 0.9 3.1 0.9 -0.7 -1.8 0.0 0.0 -0.2 1.1 -1.2 -1.0 -1.1 -0.7
Osteoarthritis (self-reported) 0.4 0.6 1.8 0.0 0.9 1.0 0.0 0.0 0.8 0.1 0.4 1.3 1.3 -0.2
Medication: Aspirin 0.1 0.2 1.4 -0.3 -0.2 1.2 0.0 0.0 -0.5 -0.1 0.0 0.2 0.1 0.2
Medication: Gliclazide 0.4 0.4 1.5 0.7 -1.2 0.4 0.0 0.0 -0.4 0.1 -1.2 -0.5 -0.3 -0.6
Illnesses of father: None of the above (group 1) 3.2 3.9 7.0 -2.1 2.1 1.9 0.0 0.0 0.8 1.9 2.6 2.6 2.6 2.5
Smoking status: Current 0.6 0.9 3.0 -1.0 0.8 1.0 0.0 0.0 1.6 0.7 0.4 0.9 0.8 1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.7 0.6 -0.5 -0.4 0.0 0.0 0.2 0.2 -0.8 -0.4 -0.5 0.4
Whole body water mass 0.2 1.0 6.1 0.1 1.3 -0.3 0.0 0.0 0.5 2.5 1.4 0.4 0.7 0.8
Leg predicted mass (right) 0.1 0.7 5.0 0.5 0.9 -0.6 0.0 0.0 0.6 2.2 0.7 -0.3 0.0 0.4
Arm fat mass (left) 0.2 1.0 9.1 -0.0 0.3 0.6 0.0 0.0 0.9 3.0 0.5 -0.2 -0.1 0.2
Number of self-reported non-cancer illnesses 0.8 1.4 2.9 -1.0 1.6 1.3 0.0 0.0 1.2 0.3 1.5 1.5 1.7 0.8
Average weekly champagne plus white wine intake 0.4 0.6 2.3 0.4 0.7 -1.4 0.0 0.0 1.5 -1.0 0.5 0.1 0.3 0.4
Miserableness 0.5 0.8 4.0 0.1 1.4 0.5 0.0 0.0 2.0 -1.6 0.1 -0.1 0.3 0.5
Guilty feelings 0.0 0.1 0.2 0.3 0.4 0.3 0.0 0.0 -0.1 -0.1 -0.2 0.4 0.4 -0.1
Wears glasses or contact lenses 0.8 0.9 3.2 -0.6 0.8 -0.6 0.0 0.0 1.8 -0.1 0.4 1.1 1.1 1.7
Ever taken oral contraceptive pill 0.3 0.3 1.8 -0.4 0.5 0.2 0.0 0.0 0.2 1.0 0.7 -0.3 0.0 1.3
Hearing aid user 1.6 1.8 4.8 -0.4 1.5 1.8 0.0 0.0 0.9 2.2 2.0 1.0 1.1 1.3
Mother’s age at death 0.2 0.2 1.1 1.1 -0.4 -0.6 0.0 0.0 0.8 0.1 -0.5 -0.1 -0.0 -0.2
Financial situation satisfaction 0.3 0.3 2.7 -0.8 -0.1 -0.3 0.0 0.0 0.4 -1.6 -0.1 0.3 0.1 -0.2
Tinnitus: Yes, now most or all of the time 0.4 0.5 2.4 0.2 0.4 -0.3 0.0 0.0 1.2 -1.5 -0.8 -0.4 -0.2 0.7
Commuting to job workplace: Public transport 0.2 0.2 0.9 -0.2 -0.7 -0.6 0.0 0.0 1.0 -0.1 -0.7 -0.4 -0.5 -0.2
Eye problems/disorders: Glaucoma 0.5 0.5 1.7 0.7 -0.6 -0.6 0.0 0.0 -1.2 -0.0 -1.3 -0.7 -0.7 -0.8
Medication: Blood pressure 0.2 0.4 2.1 1.0 -0.2 1.4 0.0 0.0 0.4 1.1 -0.2 0.5 0.5 0.0
Pain type(s) experienced in last month: Hip pain 0.4 0.4 2.6 0.1 -0.0 0.5 0.0 0.0 -0.9 -1.6 0.5 0.5 0.6 -0.7
Supplements: Fish oil (including cod liver oil) 0.8 1.1 2.1 1.0 -1.3 -1.2 0.0 0.0 1.0 -0.8 -1.2 -1.5 -1.5 -0.6
High cholesterol (Self-reported) 0.3 0.5 2.8 0.7 -1.7 0.1 0.0 0.0 0.9 0.9 -0.6 -0.4 -0.6 0.0
Medication: Bendroflumethiazide 1.3 2.0 6.9 2.0 -2.6 0.3 0.0 0.0 -0.6 0.6 -1.2 -1.4 -1.6 -2.1
Medication: Paracetamol 2.3 3.5 8.5 -2.0 2.9 0.9 0.0 0.0 1.3 1.4 2.5 2.2 2.7 1.9
Medication: Lisinopril 0.3 0.3 1.9 -0.6 -0.6 0.3 0.0 0.0 -1.4 -0.0 -0.3 0.6 0.7 0.2
Medication: Atorvastatin 0.2 0.2 0.7 -0.8 -0.6 0.7 0.0 0.0 0.3 -0.2 -0.8 -0.2 -0.2 0.2
Illnesses of father: High blood pressure 0.5 0.7 1.9 0.6 -1.4 -1.1 0.0 0.0 -0.0 -0.7 -0.9 -0.8 -1.2 0.8
Alcohol drinker status: Never 1.2 1.5 3.5 -1.3 0.5 0.2 0.0 0.0 1.4 1.0 1.8 1.7 1.9 1.3
Ever smoked 0.5 0.9 6.1 -0.3 -0.0 -0.9 0.0 0.0 1.5 -2.5 -0.4 -0.4 -0.1 0.5
Basal metabolic rate 0.2 1.2 8.3 0.1 1.2 -0.0 0.0 0.0 0.5 2.9 1.3 0.4 0.6 0.8
Leg fat percentage (left) 0.2 0.6 4.4 -0.3 0.2 1.1 0.0 0.0 0.6 2.1 0.8 0.2 0.1 0.5
Arm fat-free mass (left) 0.4 1.8 8.0 -0.5 1.7 0.1 0.0 0.0 0.0 2.8 2.0 1.1 1.3 1.2
Number of operations (self-reported) 0.9 1.3 5.0 -1.0 1.0 1.3 0.0 0.0 1.0 2.2 0.9 0.7 0.9 1.4
Average weekly beer plus cider intake 0.9 1.2 4.7 -0.6 1.1 1.8 0.0 0.0 -2.2 0.6 0.4 1.1 1.2 -0.9
Irritability 0.5 0.9 2.7 1.5 -0.6 -0.8 0.0 0.0 -0.6 0.2 -0.1 -1.4 -1.2 -1.6
Risk taking 0.3 0.5 2.8 1.2 -0.1 -0.0 0.0 0.0 1.0 -0.2 -1.7 -0.2 -0.3 0.0
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.6 -0.6 0.4 0.7 0.0 0.0 -0.0 0.4 1.3 0.5 0.4 1.1
Fractured/broken bones in last 5 years 0.5 0.6 3.4 1.3 0.5 0.2 0.0 0.0 -0.4 1.8 0.6 -0.4 -0.2 -0.6
Age started oral contraceptive pill 1.1 1.4 2.8 1.7 -1.3 -0.1 0.0 0.0 -0.6 0.5 -1.6 -1.6 -1.7 -1.3
Diastolic blood pressure, automated reading 1.8 5.6 16.2 3.4 -2.2 -2.3 0.0 0.0 4.0 -1.0 -1.5 -3.2 -3.2 -0.7
Ever depressed for a whole week 0.2 0.2 0.6 -0.6 -0.2 -0.5 0.0 0.0 0.8 -0.6 0.2 -0.5 -0.5 -0.6
Unable to work because of sickness or disability 0.2 0.3 1.3 0.2 -0.7 1.1 0.0 0.0 -1.1 -0.4 -0.3 -0.1 -0.2 -0.1
Commuting to job workplace: Cycle 1.0 1.2 3.8 0.1 1.5 1.3 0.0 0.0 0.8 -1.1 1.9 0.8 1.0 1.3
Myopia 0.5 0.7 1.9 1.1 -1.3 0.3 0.0 0.0 0.9 0.0 -0.4 -1.3 -1.4 0.3
Vascular/heart problems diagnosed by doctor 0.3 0.8 3.6 0.6 1.1 -1.9 0.0 0.0 1.3 -1.3 0.4 -0.5 -0.4 0.1
Cholesterol lowering medication 0.5 0.7 2.3 1.2 -1.5 0.2 0.0 0.0 0.3 1.5 -1.0 -0.6 -0.6 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 2.4 -0.5 0.2 -0.3 0.0 0.0 0.5 1.6 1.2 0.2 0.4 0.6
Pain experienced in last month 1.2 1.9 6.4 0.5 -1.4 -1.0 0.0 0.0 -2.5 -0.1 -1.8 -1.4 -1.5 -2.0
Supplements: Calcium 0.2 0.2 1.3 -0.0 -0.2 0.1 0.0 0.0 0.8 1.1 0.5 -0.1 -0.1 0.5
Basal cell carcinoma (self-reported) 0.1 0.1 0.5 0.6 0.2 0.2 0.0 0.0 -0.2 0.5 -0.1 -0.5 -0.7 -0.3
Heart attack/myocardial infarction (self-reported) 1.4 1.8 11.9 -0.4 -0.1 1.7 0.0 0.0 -3.5 -0.9 -0.2 0.5 0.5 -1.9
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 5.3 -0.9 1.2 -0.7 0.0 0.0 0.5 -0.3 2.3 0.7 0.9 1.7
Heart disease (siblings) 0.5 0.7 2.0 -0.1 -1.2 0.3 0.0 0.0 -1.4 0.1 -0.7 -1.2 -1.2 -0.6
Alcohol drinker status: Previous 0.4 0.4 1.6 0.3 -0.5 -0.2 0.0 0.0 1.2 -1.1 0.3 -0.7 -0.6 0.7
Pack years of smoking 0.9 1.3 3.6 -1.9 1.4 0.3 0.0 0.0 -0.3 0.4 1.1 1.8 1.7 1.2
Impedance of whole body 0.3 1.3 5.3 -1.0 -0.1 2.2 0.0 0.0 -2.3 -0.4 -0.5 1.3 0.9 -0.3
Leg fat mass (left) 0.3 1.0 7.0 -0.4 0.6 1.1 0.0 0.0 0.4 2.7 1.2 0.5 0.5 0.7
Arm predicted mass (left) 0.2 1.3 7.1 -0.1 1.4 -0.1 0.0 0.0 0.4 2.7 1.6 0.7 0.9 1.0