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chr17:554,080-3,287,175

Best TWAS P=1.33e-18 · Best GWAS P=3.44e-22 conditioned to 8.1e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SMG6	0.04	0.05	lasso	2	0.04	8.8e-06	7.29	-7.7	1.9e-14	-0.59	0.51	0.25	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SRR	0.27	0.48	lasso	1	0.48	3.5e-65	-6.58	6.6	4.6e-11	0.49	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	SRR	0.16	0.16	lasso	9	0.18	1.9e-14	-7.70	7.3	2.9e-13	0.48	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	SRR	0.29	0.26	lasso	5	0.25	1.8e-13	-6.58	7.0	2.0e-12	0.52	1.00	0.00	FALSE
5	GTEx	Adrenal Gland	SRR	0.38	0.37	lasso	6	0.38	8.1e-15	-6.58	5.9	4.4e-09	0.40	1.00	0.00	FALSE
6	GTEx	Artery Aorta	SRR	0.33	0.33	lasso	2	0.32	6.1e-18	-6.58	6.6	4.3e-11	0.47	1.00	0.00	FALSE
7	GTEx	Artery Coronary	SRR	0.44	0.28	lasso	8	0.26	2.5e-09	-7.70	8.4	2.9e-17	0.58	0.89	0.10	FALSE
8	GTEx	Artery Tibial	CRK	0.19	0.14	lasso	6	0.18	3.5e-14	-6.25	-6.8	7.9e-12	-0.04	0.01	0.99	FALSE
9	GTEx	Artery Tibial	SRR	0.22	0.23	lasso	4	0.24	3.9e-19	-7.70	7.8	5.5e-15	0.58	1.00	0.00	FALSE
10	GTEx	Brain Caudate basal ganglia	SRR	0.26	0.03	lasso	3	0.02	8.6e-02	-8.88	8.8	1.6e-18	0.68	0.07	0.50	FALSE
11	GTEx	Brain Cerebellar Hemisphere	SRR	0.37	0.24	lasso	7	0.22	2.1e-06	-6.58	7.8	8.2e-15	0.56	0.29	0.55	FALSE
12	GTEx	Brain Cerebellum	SMG6	0.24	0.03	enet	16	0.05	1.3e-02	-5.79	-8.6	1.2e-17	-0.61	0.08	0.23	FALSE
13	GTEx	Brain Cerebellum	SRR	0.26	0.20	lasso	3	0.21	8.7e-07	-6.58	6.6	3.3e-11	0.43	0.30	0.26	FALSE
14	GTEx	Brain Cortex	CRK	0.29	0.01	enet	13	0.01	1.7e-01	-5.72	-6.5	6.7e-11	-0.08	0.03	0.66	FALSE
15	GTEx	Brain Frontal Cortex BA9	SRR	0.25	0.24	lasso	3	0.21	3.5e-06	-6.58	6.4	1.5e-10	0.45	0.26	0.10	FALSE
16	GTEx	Breast Mammary Tissue	SRR	0.20	0.21	lasso	3	0.20	8.2e-11	-7.61	8.1	5.9e-16	0.56	1.00	0.00	FALSE
17	GTEx	Breast Mammary Tissue (Female)	SRR	0.24	0.25	lasso	3	0.21	6.3e-07	-7.61	7.6	2.5e-14	0.53	0.70	0.13	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	SRR	0.39	0.34	lasso	5	0.35	3.1e-12	-6.58	7.0	3.7e-12	0.48	0.99	0.01	FALSE
19	GTEx	Cells Transformed fibroblasts	SRR	0.36	0.38	lasso	4	0.38	8.2e-30	-6.58	6.7	1.7e-11	0.49	1.00	0.00	FALSE
20	GTEx	Colon Sigmoid	SRR	0.32	0.35	enet	8	0.32	9.2e-12	-6.58	7.4	1.9e-13	0.52	1.00	0.00	FALSE
21	GTEx	Colon Transverse	SRR	0.28	0.21	lasso	5	0.19	1.6e-09	-6.58	6.7	1.9e-11	0.50	0.99	0.01	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	CRK	0.24	0.08	lasso	4	0.06	4.2e-03	-6.28	-6.3	3.0e-10	-0.06	0.01	0.92	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	SRR	0.40	0.35	lasso	3	0.36	1.1e-13	-6.58	6.7	2.5e-11	0.50	0.99	0.01	FALSE
24	GTEx	Esophagus Mucosa	SRR	0.23	0.24	lasso	5	0.24	2.0e-16	-7.73	7.4	1.6e-13	0.49	1.00	0.00	FALSE
25	GTEx	Esophagus Muscularis	CRK	0.20	0.20	enet	16	0.21	4.0e-13	-6.25	-5.9	3.7e-09	-0.04	0.01	0.99	FALSE
26	GTEx	Esophagus Muscularis	SRR	0.30	0.39	lasso	3	0.38	3.4e-24	-6.58	6.8	1.1e-11	0.51	1.00	0.00	FALSE
27	GTEx	Heart Atrial Appendage	SRR	0.35	0.30	lasso	7	0.29	1.4e-13	-7.73	8.8	1.7e-18	0.64	0.92	0.08	FALSE
28	GTEx	Heart Left Ventricle	SRR	0.15	0.16	lasso	3	0.13	2.9e-07	-6.58	6.5	1.0e-10	0.47	0.60	0.38	FALSE
29	GTEx	Liver	SRR	0.31	0.00	lasso	7	0.00	3.0e-01	-0.16	7.4	1.6e-13	0.57	0.04	0.50	FALSE
30	GTEx	Lung	SRR	0.24	0.28	lasso	2	0.26	3.4e-20	-6.58	6.8	7.6e-12	0.51	1.00	0.00	FALSE
31	GTEx	Lung	RP1-59D14.5	0.25	0.00	enet	34	0.02	1.9e-02	3.19	5.6	2.0e-08	0.11	0.07	0.04	FALSE
32	GTEx	Muscle Skeletal	PAFAH1B1	0.17	0.05	lasso	7	0.04	6.5e-05	5.45	6.0	2.4e-09	0.12	0.92	0.00	TRUE
33	GTEx	Muscle Skeletal	METTL16	0.19	0.06	enet	22	0.07	1.0e-07	4.21	6.0	1.8e-09	0.30	0.90	0.01	FALSE
34	GTEx	Muscle Skeletal	SRR	0.27	0.27	lasso	6	0.27	7.1e-27	-6.58	7.0	2.3e-12	0.52	1.00	0.00	FALSE
35	GTEx	Nerve Tibial	CRK	0.23	0.12	lasso	6	0.17	2.5e-12	-6.28	-7.0	3.5e-12	-0.05	0.01	0.99	FALSE
36	GTEx	Nerve Tibial	SRR	0.15	0.13	lasso	3	0.13	2.9e-09	-7.70	8.2	1.9e-16	0.59	0.97	0.03	FALSE
37	GTEx	Pancreas	SRR	0.13	0.17	lasso	3	0.15	5.2e-07	-7.73	7.4	1.8e-13	0.52	0.93	0.03	FALSE
38	GTEx	Skin Not Sun Exposed Suprapubic	SRR	0.18	0.16	enet	18	0.19	7.9e-11	-6.58	6.9	4.7e-12	0.49	0.96	0.02	FALSE
39	GTEx	Skin Sun Exposed Lower leg	SRR	0.13	0.15	lasso	4	0.14	2.0e-11	-6.58	7.4	1.2e-13	0.58	0.87	0.13	FALSE
40	GTEx	Small Intestine Terminal Ileum	WDR81	0.55	-0.01	enet	53	0.02	1.2e-01	-4.26	5.2	2.5e-07	0.12	0.06	0.05	TRUE
41	GTEx	Spleen	SRR	0.21	0.10	lasso	4	0.04	3.1e-02	-6.58	6.7	1.9e-11	0.52	0.12	0.13	FALSE
42	GTEx	Stomach	CRK	0.18	0.06	lasso	5	0.08	1.8e-04	6.43	-7.4	1.7e-13	-0.05	0.00	0.99	TRUE
43	GTEx	Stomach	SRR	0.27	0.30	lasso	7	0.28	7.1e-14	-7.67	7.7	1.2e-14	0.54	1.00	0.00	FALSE
44	GTEx	Testis	SRR	0.13	0.12	lasso	2	0.09	6.6e-05	-6.20	6.5	1.1e-10	0.49	0.48	0.18	FALSE
45	GTEx	Thyroid	YWHAE	0.10	0.01	lasso	5	0.01	4.9e-02	-5.72	-6.8	7.3e-12	-0.03	0.01	0.95	FALSE
46	GTEx	Thyroid	CRK	0.12	0.05	enet	10	0.10	5.9e-08	-5.41	-5.6	2.6e-08	-0.02	0.01	0.99	FALSE
47	GTEx	Thyroid	SRR	0.26	0.27	lasso	4	0.25	2.0e-19	-6.58	6.7	2.2e-11	0.50	1.00	0.00	FALSE
48	GTEx	Vagina	SRR	0.18	0.13	lasso	2	0.11	1.6e-03	-7.39	8.1	6.9e-16	0.63	0.05	0.60	FALSE
49	GTEx	Whole Blood	SRR	0.09	0.03	enet	8	0.02	4.5e-03	-6.58	8.4	4.0e-17	0.67	0.07	0.91	FALSE
50	METSIM	Adipose	AC006435.1	0.11	0.05	lasso	11	0.07	9.4e-11	4.25	-6.5	5.6e-11	-0.27	0.99	0.00	FALSE
51	METSIM	Adipose	SRR	0.07	0.07	enet	21	0.06	4.4e-09	-6.58	6.4	1.9e-10	0.44	1.00	0.00	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	PAFAH1B1	0.10	0.03	enet	19	0.06	1.1e-08	5.11	5.3	9.0e-08	0.07	0.99	0.00	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	SMG6	0.10	0.03	blup	520	0.04	4.0e-06	8.14	-5.8	7.0e-09	-0.32	0.71	0.21	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	CRK	0.08	0.08	lasso	7	0.07	1.3e-09	-6.20	-6.2	7.5e-10	-0.02	0.01	0.99	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	SRR	0.25	0.39	lasso	3	0.39	5.6e-53	-6.58	6.8	1.1e-11	0.49	1.00	0.00	FALSE
56	YFS	Blood	PAFAH1B1	0.13	0.10	enet	31	0.09	6.1e-29	-4.97	-5.8	5.8e-09	-0.07	1.00	0.00	FALSE
57	YFS	Blood	SRR	0.17	0.22	lasso	7	0.23	2.5e-72	-6.58	7.3	2.0e-13	0.52	1.00	0.00	FALSE
58	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SRR	0.11	0.09	lasso	4	0.10	6.8e-09	-6.58	7.1	1.7e-12	0.54	0.01	0.99	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	SRR	0.16	0.16	lasso	5	0.16	2.3e-32	-7.70	7.5	8.8e-14	0.51	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Colon Adenocarcinoma	SRR	0.32	0.24	lasso	3	0.23	1.5e-13	-6.58	6.3	2.1e-10	0.46	0.03	0.97	FALSE
61	The Cancer Genome Atlas	Esophageal Carcinoma	SRR	0.32	0.13	lasso	2	0.16	9.2e-06	-6.20	6.2	5.4e-10	0.47	0.09	0.84	FALSE
62	The Cancer Genome Atlas	Glioblastoma Multiforme	SRR	0.24	0.16	lasso	1	0.13	9.0e-05	-6.58	6.6	4.6e-11	0.49	0.00	0.96	FALSE
63	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SRR	0.10	0.10	lasso	2	0.09	1.0e-10	-6.58	7.0	3.0e-12	0.51	0.01	0.99	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SRR	0.30	0.40	lasso	7	0.39	8.5e-47	-7.70	7.2	4.9e-13	0.49	0.00	1.00	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SRR	0.22	0.23	lasso	2	0.21	2.3e-12	-6.58	6.7	2.0e-11	0.49	0.01	0.99	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	SRR	0.29	0.26	lasso	2	0.27	1.9e-30	-7.70	7.3	3.8e-13	0.52	0.00	1.00	FALSE
67	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	OVCA2	0.16	0.00	blup	47	0.00	6.7e-01	-1.42	6.2	5.0e-10	0.37	0.01	0.04	FALSE
68	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SRR	0.08	0.09	enet	3	0.08	1.7e-04	-6.58	7.0	2.5e-12	0.51	0.00	0.97	FALSE
69	The Cancer Genome Atlas	Lung Adenocarcinoma	SRR	0.14	0.18	lasso	2	0.18	4.3e-21	-6.58	7.0	2.7e-12	0.51	0.01	0.99	FALSE
70	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SRR	0.11	0.12	lasso	2	0.12	4.3e-13	-6.58	6.5	6.3e-11	0.48	0.03	0.97	FALSE
71	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SRR	0.16	0.20	lasso	3	0.20	2.8e-13	-7.73	7.6	3.7e-14	0.51	0.00	1.00	FALSE
72	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SRR	0.34	0.30	lasso	4	0.30	2.9e-13	-6.58	6.6	5.4e-11	0.49	0.01	0.99	FALSE
73	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SRR	0.27	0.19	enet	5	0.21	8.9e-09	-7.73	7.3	2.0e-13	0.51	0.00	1.00	FALSE
74	The Cancer Genome Atlas	Prostate Adenocarcinoma	SMG6	0.04	0.01	blup	144	0.02	5.5e-03	-6.00	-8.8	1.3e-18	-0.54	0.07	0.34	TRUE
75	The Cancer Genome Atlas	Prostate Adenocarcinoma	SRR	0.30	0.35	lasso	3	0.36	7.5e-39	-6.58	7.0	3.3e-12	0.50	0.01	0.99	FALSE
76	The Cancer Genome Atlas	Rectum Adenocarcinoma	SRR	0.52	0.32	lasso	3	0.40	1.7e-10	-6.58	7.8	6.7e-15	0.56	0.00	0.99	FALSE
77	The Cancer Genome Atlas	Soft Tissue Sarcoma	SRR	0.20	0.18	lasso	2	0.20	8.8e-12	-6.58	7.2	6.2e-13	0.52	0.00	1.00	FALSE
78	The Cancer Genome Atlas	Stomach Adenocarcinoma	SRR	0.21	0.15	enet	11	0.16	1.1e-11	-7.70	7.4	1.3e-13	0.49	0.00	1.00	FALSE
79	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SRR	0.35	0.07	enet	11	0.14	1.1e-05	-7.70	8.2	1.8e-16	0.60	0.00	0.99	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	SRR	0.56	0.50	lasso	4	0.50	5.2e-55	-6.58	6.8	9.2e-12	0.48	0.77	0.23	FALSE