Hub : Genes

PAFAH1B1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.1662 0.0427 1.4e-06 0.054 NA 0.038 NA 0.041 4.5e-06 NA 1.2e-04 NA 6.5e-05
2 ROSMAP Brain Pre-frontal Cortex 0.0963 0.0267 2.6e-06 0.033 0.060 0.064 0.063 0.063 4.1e-05 3.1e-08 1.1e-08 1.4e-08 1.4e-08
3 YFS Blood 0.1339 0.0234 0.0e+00 0.099 0.076 0.093 0.082 0.068 1.2e-30 1.4e-23 6.1e-29 1.8e-25 3.5e-21
4 TCGA Colon Adenocarcinoma 0.1130 0.0590 3.1e-03 0.001 0.036 0.015 NA 0.013 2.7e-01 3.6e-03 4.1e-02 NA 5.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.6 2.6 6.8 -0.7 -2.6 0.6 -1.7
Bipolar Disorder or Schizophrenia 0.2 0.5 1.5 0.2 -1.2 -0.5 -0.3
Depressed Affect (Nagel 2018) 2.7 5.7 21.3 0.8 -0.2 -4.6 -1.0
Depression (Nagel 2018) 1.3 2.0 7.3 -0.1 -0.4 -2.7 -0.7
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.1 0.7 -0.6 1.1 -0.4
Neuroticism (Nagel 2018) 3.7 8.7 28.9 2.2 1.1 -5.4 0.1
Schizophrenia (2018) 0.4 0.8 1.6 0.9 0.6 -1.3 0.8
Schizophrenia vs Biploar Disorder 2.5 3.2 3.6 1.6 1.9 -1.9 1.8
Worry (Nagel 2018) 2.4 5.1 10.0 2.8 1.4 -3.2 0.6
Alzheimer’s Disease (in mother) 0.1 0.1 0.1 -0.1 0.4 -0.3 -0.1
Alzheimer’s Disease (in father) 2.9 3.1 4.7 1.8 2.2 -1.7 1.3
Alzheimer’s Disease (including proxy) 1.2 1.8 3.3 1.2 1.8 -1.0 1.2
Crohns Disease (2017) 3.5 7.6 10.7 -3.3 -2.7 1.7 -3.1
Irritable Bowel Disease (IBD) 2.2 5.3 10.2 -3.2 -1.9 1.0 -2.5
Ulcerative Colitis (UC) 0.8 1.4 3.6 -1.9 -0.7 0.4 -1.2
Major Depression (MDD) 2.3 2.8 5.6 -1.3 -2.4 1.1 -1.7
Reaction Time 0.6 1.1 3.8 -0.2 -0.4 1.9 0.7
Verbal and Numeric Reasoning (VNR) 0.5 1.2 3.5 0.7 -1.9 0.7 -0.5
Breast Cancer 1.8 4.3 10.1 1.7 2.0 -3.2 -0.5
Ovarian Cancer 0.3 0.5 0.8 -0.9 0.6 0.7 0.3
Prostate Cancer 0.2 0.3 0.9 0.4 0.3 -0.9 -0.3
Age at First Birth 1.5 2.2 3.2 1.7 1.8 -1.3 1.1
Bipolar Disorder (2011) 0.1 0.1 0.3 0.0 0.0 0.0 0.5
Body Mass Index (BMI) (2010) 0.8 1.2 1.5 -1.2 -1.1 0.7 -1.2
Coronary Artery Disease (CAD) 2.7 3.2 6.1 -2.5 -2.2 0.2 -1.3
Crohns Disease (2012) 1.7 2.7 3.1 -1.7 -1.8 1.5 -1.6
Mean Putamen Volume 2.1 2.4 4.0 -1.3 -2.0 1.9 -0.5
Fasting Glucose 0.3 0.4 0.8 -0.5 -0.2 0.9 -0.7
HbA1C 0.3 0.4 0.7 -0.8 -0.3 -0.1 0.8
HDL Cholesterol 0.6 0.9 1.7 1.2 0.3 -1.3 -0.7
LDL Cholesterol 0.2 0.3 0.5 0.4 -0.7 0.7 0.3
Lupus 0.2 0.3 0.6 0.8 0.3 -0.1 0.6
Neuroticism (2016) 3.7 5.4 14.5 -0.2 -0.1 -3.8 -2.6
Primary Biliary Cirrhosis 1.0 1.4 2.0 -1.2 -1.4 0.6 -1.4
Rheumatoid Arthritis 0.4 0.5 1.5 -0.4 0.5 0.4 1.2
Schizophrenia (2014) 0.5 1.1 3.3 1.0 -0.2 -1.8 0.4
Triglycerides 0.7 1.2 3.1 -1.1 -0.7 0.1 -1.8
Type 2 Diabetes (T2D) (2012) 1.7 1.9 2.9 -1.6 -1.7 1.0 -1.1
Ulcerative Colitis 1.7 2.4 3.3 -1.8 -1.7 1.7 -0.8
Blood Eosinophil Count 0.4 3.4 6.1 -2.5 -2.1 1.7 0.5
Blood Platelet Count 2.2 25.7 34.6 5.9 5.4 -3.6 5.1
Blood Red Count 0.5 4.6 8.4 2.1 2.9 -1.1 2.1
Blood White Count 1.0 7.6 16.1 1.6 3.4 -0.2 4.0
Heel T-Score 2.0 15.6 22.0 -4.3 -4.7 2.3 -4.0
BMI 0.9 5.1 8.7 -2.7 -1.7 -1.0 -3.0
Height 0.2 4.4 16.3 0.3 0.9 4.0 0.7
Waist Hip Ratio (WHR) 0.4 1.6 5.4 -2.3 -0.5 0.8 0.5
Systolic Blood Pressure 5.4 27.3 35.6 6.0 5.3 -5.8 3.3
Smoking Status 2.5 5.9 14.3 -3.8 -1.7 -1.3 -2.2
Allergy or Eczema 0.3 0.8 1.9 -1.4 -0.6 -0.8 -0.5
Cardiovascular Disease 0.8 2.7 5.2 -1.6 -1.2 -1.2 -2.3
Hypothyroidism (self reported) 0.3 0.6 1.1 1.0 0.6 -1.1 -0.2
Respiratory disease 0.1 0.2 0.5 0.7 -0.4 -0.6 0.1
Type 2 Diabetes (T2D) (2018) 0.8 1.5 3.8 -1.1 -0.9 0.6 -1.9
Lung FEV1/FVC ratio 0.1 0.3 0.8 -0.9 -0.1 -0.1 0.5
Lung FVC 0.3 1.5 3.0 1.7 -0.7 0.9 1.4
Neuroticism 3.8 9.2 27.8 2.0 2.1 -5.3 0.8
Chronotype (morning person) 0.8 1.9 5.9 2.4 1.3 -0.4 -0.2
Hair Pigment 0.0 0.6 2.3 -1.5 -0.5 -0.0 -0.2
Tanning 0.1 0.7 1.9 0.4 1.4 0.6 0.5
Hand grip strength (left) 0.6 1.6 2.9 -0.9 -1.7 1.3 -1.0
Number of treatments/medications taken 0.3 0.5 1.6 -0.1 -0.3 -1.2 -0.7
Average weekly spirits intake 0.0 0.0 0.1 -0.2 -0.2 -0.0 0.1
Sensitivity / hurt feelings 1.8 3.0 10.3 0.7 1.2 -3.2 0.1
Frequency of depressed mood in last 2 weeks 3.1 4.3 15.8 -0.3 0.7 -4.0 -1.0
Hearing difficulty/problems: Yes 1.8 2.7 5.1 0.8 0.6 -2.2 -2.3
Relative age of first facial hair 0.3 0.7 1.7 0.9 1.3 -0.7 0.0
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 2.0 1.1 1.2 -1.4 -0.6
Ever used hormone-replacement therapy (HRT) 2.4 3.0 4.8 1.9 2.2 -1.8 0.6
Ever had hysterectomy (womb removed) 2.3 2.6 6.8 1.2 1.3 -2.6 -0.5
Systolic blood pressure, automated reading 6.2 18.0 23.5 4.8 4.7 -4.4 2.7
Eye problems/disorders: Diabetes related eye disease 4.9 5.3 8.0 -2.1 -2.8 2.1 -2.1
Angina 0.2 0.2 0.7 0.2 -0.9 -0.2 0.0
Medication for hormone replacement therapy 2.1 2.4 6.4 1.3 1.1 -0.4 2.5
Vitamin and mineral supplements 0.2 0.3 0.5 -0.5 -0.4 0.4 -0.7
Supplements: Zinc 1.3 1.4 2.7 1.6 1.2 -1.1 -0.1
Medication: Co-codamol 0.8 1.0 3.1 -0.5 -0.5 -1.8 -0.5
Medication: Metformin 1.0 1.4 4.2 -0.7 -0.6 0.7 -2.0
Diabetes (father) 1.6 1.9 3.4 1.1 1.3 -1.9 -1.2
Diabetes (mother) 0.6 0.7 1.6 0.3 1.3 0.1 1.1
Severe depression (siblings) 1.3 1.5 4.2 -1.2 0.5 -2.0 0.1
Pack years adult smoking proportion 1.8 2.7 5.6 0.7 2.0 -2.4 -0.8
Impedance of leg (right) 3.6 17.2 29.9 4.9 3.8 0.1 5.5
Leg fat-free mass (left) 1.9 10.2 16.4 -3.9 -2.8 1.2 -4.0
Trunk fat percentage 0.5 2.1 3.8 1.2 1.3 -1.9 1.3
Hand grip strength (right) 0.1 0.2 0.5 -0.3 -0.7 -0.1 -0.2
Townsend deprivation index at recruitment 0.9 1.3 3.8 -0.2 1.2 -2.0 -0.1
Current tobacco smoking 1.0 1.6 3.9 -1.2 1.0 -2.0 -0.3
Average weekly fortified wine intake 1.9 2.2 5.2 -0.8 -1.7 2.3 -0.5
Maternal smoking around birth 0.2 0.3 0.6 -0.5 0.3 -0.3 -0.8
Fed-up feelings 2.5 4.5 17.0 -0.7 0.2 -4.1 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.7 5.3 -0.9 -0.7 -2.3 -0.2
Relative age voice broke 0.3 0.5 1.1 -0.3 0.5 1.1 -0.8
Taking other prescription medications 1.3 1.9 6.4 0.7 -0.3 -2.5 -0.9
Age when periods started (menarche) 0.1 0.2 0.4 0.1 -0.5 0.6 0.6
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 2.0 0.5 1.4 -0.8 0.2
Heel bone mineral density (BMD) T-score, automated (left) 1.6 3.6 7.4 -1.3 -2.1 -1.0 -2.7
Tinnitus: Yes, but not now, but have in the past 1.9 2.0 3.4 -1.6 -1.8 1.3 0.5
Qualifications: CSEs or equivalent 0.2 0.3 1.0 -0.1 0.2 -1.0 -0.5
Serious illness, injury or assault to yourself 0.2 0.2 0.7 0.2 -0.1 0.8 0.3
High blood pressure 0.2 0.5 1.0 -0.4 -0.1 -0.9 -1.0
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.0 -1.0 -0.7 -1.0 -0.7
Multivitamins +/- minerals 0.3 0.4 1.0 0.1 0.8 0.4 1.0
Stomach or abdominal pain in last month 2.2 2.8 5.6 -1.8 -0.6 -2.4 -1.4
Supplements: Glucosamine 0.3 0.4 1.1 -0.2 -0.4 1.0 0.6
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.1 1.0 0.6 -0.7 0.3
Medication: Atenolol 0.6 0.7 1.3 -1.1 -0.5 -0.5 -1.1
Medication: Levothyroxine sodium 0.0 0.0 0.1 0.2 0.2 -0.1 -0.3
Sitting height 0.3 2.1 8.4 0.1 -0.3 2.9 -0.3
Chronic bronchitis/emphysema (father) 1.1 1.3 3.7 -1.2 -0.2 0.1 -1.9
High blood pressure (mother) 0.1 0.1 0.4 0.2 0.1 -0.6 -0.1
Body mass index (BMI) 1.0 4.4 8.1 -1.7 -0.8 -2.4 -2.8
Impedance of leg (left) 3.9 18.8 30.7 5.2 4.2 -0.4 5.5
Leg predicted mass (left) 1.9 10.1 16.2 -3.9 -2.8 1.2 -4.0
Trunk fat mass 0.1 0.6 1.9 0.1 0.7 -1.4 -0.0
Waist circumference 0.5 1.8 3.6 -1.4 -0.1 -1.9 -1.3
Number of incorrect matches in round 1.4 2.3 3.1 1.8 1.6 -1.3 1.4
Past tobacco smoking 3.1 5.7 13.2 3.6 2.3 -0.1 2.1
Alcohol usually taken with meals 0.7 1.2 2.5 -1.6 -0.6 1.3 -0.3
Nervous feelings 1.8 3.4 9.2 1.7 1.0 -3.0 0.6
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.7 5.9 -1.4 -1.6 -2.4 -0.8
Hearing difficulty/problems with background noise 4.8 7.6 17.9 -1.2 0.3 -4.2 -3.3
Hair/balding pattern: Pattern 2 0.5 0.6 2.0 1.4 0.4 -0.2 0.4
Had menopause 1.0 1.2 2.4 1.1 1.1 -1.5 0.1
Had other major operations 0.2 0.2 0.4 -0.6 0.3 -0.4 0.5
Forced vital capacity (FVC) 0.7 2.8 9.2 0.0 -1.0 3.0 1.1
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.2 7.3 -0.7 -1.7 -1.5 -2.7
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 2.4 -0.1 -1.5 -1.0 0.3
Qualifications: None of the above 0.8 1.7 2.9 0.9 1.4 -1.7 1.1
Financial difficulties in last 2 years 0.6 0.9 3.0 -0.5 -0.5 -1.7 0.0
Mouth/teeth dental problems 0.5 0.8 3.0 1.7 -0.5 0.2 -0.1
Heart attack 2.1 2.7 3.9 -2.0 -1.9 1.3 -1.3
Allergy 0.6 1.3 2.2 1.4 1.5 0.2 1.1
Pain all over the body in last month 1.6 1.7 3.3 1.8 1.3 -1.0 1.0
Diabetes (self-reported) 1.7 2.7 6.8 -1.2 -1.5 0.3 -2.6
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 2.7 0.6 1.0 -1.6 -1.3
Medication: Ramipril 0.4 0.6 1.3 -1.1 -0.8 -0.5 0.2
Medication: Simvastatin 0.3 0.5 1.7 0.4 -0.2 -1.3 -0.4
Fluid intelligence score 0.3 0.6 1.5 1.2 -1.0 0.1 -0.2
Illnesses of siblings 0.5 0.7 1.5 1.2 0.1 0.5 0.9
Neuroticism score 4.0 8.4 27.1 1.3 2.1 -5.2 0.6
Weight 0.5 2.6 6.1 -1.9 -0.8 -0.5 -2.5
Impedance of arm (right) 3.7 17.1 39.4 4.7 2.6 0.3 6.3
Arm fat percentage (right) 0.4 1.6 5.8 0.3 0.7 -2.4 0.2
Trunk fat-free mass 1.8 10.4 17.9 -3.8 -2.2 2.1 -4.2
Hip circumference 0.3 1.5 3.6 0.1 -0.2 -1.9 -1.5
Time employed in main current job 1.0 1.2 1.9 1.4 0.0 1.3 1.1
Alcohol intake versus 10 years previously 1.5 2.3 3.9 -1.4 -2.0 0.7 -1.7
Father’s age at death 3.1 4.2 8.4 1.4 2.9 -0.9 2.4
Worrier / anxious feelings 1.1 2.2 7.8 0.3 0.6 -2.8 -0.6
Frequency of tiredness / lethargy in last 2 weeks 5.4 8.8 33.5 -0.5 0.4 -5.8 -1.1
Falls in the last year 0.7 0.9 3.3 -0.2 -0.3 0.3 -1.8
Hair/balding pattern: Pattern 3 1.4 2.2 3.8 1.0 1.7 -0.9 1.9
Number of live births 1.4 2.0 3.8 -1.5 -1.5 0.2 -1.9
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 4.2 0.2 -0.6 2.1 1.5
Pulse rate 1.7 2.8 4.7 1.1 1.6 -1.7 2.2
Happiness 0.8 1.0 1.8 -1.3 -0.7 -1.4 -0.0
Noisy workplace 0.5 0.6 1.2 0.5 1.1 -0.8 0.3
Qualifications: A levels/AS levels or equivalent 0.5 1.1 2.3 1.1 0.8 -0.6 1.5
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.5 -0.4 -0.0 -0.2 -0.7
Mouth/teeth dental problems: Dentures 0.6 1.1 2.2 -1.5 1.0 0.6 0.9
Asthma 0.4 0.9 1.8 -0.7 -1.3 1.0 -0.2
Medication: Ibuprofen (e.g. Nurofen) 1.7 2.1 5.8 1.2 1.1 -0.2 2.4
Medication: Cholesterol lowering 0.6 0.9 2.2 0.2 -1.2 0.3 -1.5
Depression (self-reported) 0.9 1.0 1.7 -0.9 -1.3 -0.2 -1.3
Medication: Lansoprazole 0.5 0.6 1.4 -1.2 -0.6 0.8 -0.0
Prospective memory result 0.5 0.6 1.5 -0.9 1.2 0.1 0.5
Lung cancer (father) 1.6 1.8 2.6 -1.6 -0.6 1.6 -1.4
Illnesses of mother 0.4 0.5 1.2 -0.5 -0.6 -1.1 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.1 3.0 0.2 -0.4 1.7 1.2
Pulse wave Arterial Stiffness index 0.3 0.3 0.9 -0.1 1.0 -0.2 -0.5
Impedance of arm (left) 3.4 15.9 42.7 4.1 1.9 1.0 6.5
Arm fat mass (right) 0.3 1.3 3.2 -0.8 -0.1 -1.8 -1.1
Trunk predicted mass 1.8 10.0 17.1 -3.7 -2.2 2.2 -4.1
Standing height 0.4 4.1 15.9 -0.7 -0.3 4.0 0.2
Length of working week for main job 1.0 1.1 2.9 -0.8 -1.7 0.3 -1.0
Exposure to tobacco smoke at home 0.3 0.4 0.5 0.6 -0.4 0.7 -0.7
Breastfed as a baby 0.6 0.7 1.2 -1.0 -1.1 0.7 -0.1
Tense / ‘highly strung’ 0.4 0.6 1.3 0.5 0.3 -1.1 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 2.3 3.6 7.5 -2.7 -1.5 0.2 -2.1
Hair/balding pattern: Pattern 4 0.3 0.7 2.2 1.5 -0.8 -0.1 -0.1
Birth weight of first child 3.3 6.0 16.4 1.3 2.1 -4.0 -1.2
Peak expiratory flow (PEF) 0.9 2.0 4.8 2.2 1.3 -0.4 1.1
Pulse wave reflection index 0.7 0.9 1.6 1.2 1.3 -0.4 -0.6
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.0 -1.0 -0.8 0.1 0.1
Loud music exposure frequency 1.2 1.3 3.7 0.2 1.1 -1.9 -0.3
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 3.4 1.6 0.8 -0.4 1.9
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.6 -0.2 -0.3 0.3 0.8
Blood clot in the leg (DVT) 0.5 0.6 1.0 -0.7 -1.0 1.0 -0.1
Medication: Paracetamol 0.9 1.4 3.0 0.8 1.2 -1.7 -0.8
Headache pain in last month 1.1 1.8 4.9 0.6 0.6 -2.2 -1.3
Medication for cholesterol, blood pressure or diabetes 1.7 2.8 3.8 1.5 1.9 -1.1 1.9
Glaucoma (self-reported) 0.9 1.1 2.2 1.1 1.5 -0.9 -0.0
Gout (self-reported) 0.8 1.1 2.8 0.2 1.1 -0.7 1.7
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.6 0.7 0.3 -0.3 -0.1
Medication: Amlodipine 0.2 0.2 0.5 -0.5 -0.7 -0.0 -0.2
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.3 -0.0 0.1 -0.1 0.6
Birth weight 0.5 1.2 3.6 1.9 -0.5 -0.6 -0.6
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.8 0.1 -0.2 -1.2 -1.3
High blood pressure (siblings) 0.2 0.3 0.6 0.1 0.5 -0.8 0.7
Forced vital capacity (FVC), Best measure 0.4 1.4 3.9 0.7 0.0 2.0 1.0
Body fat percentage 0.6 2.4 5.2 1.2 1.5 -2.3 1.0
Leg fat percentage (right) 1.4 5.1 12.1 1.4 2.4 -3.5 0.6
Arm fat-free mass (right) 2.4 12.4 24.5 -4.1 -2.5 1.4 -5.0
Exposure to tobacco smoke outside home 3.8 5.0 6.8 2.0 2.5 -2.6 1.8
Comparative body size at age 10 0.2 0.4 0.6 0.8 -0.5 -0.6 -0.7
Number of full brothers 1.1 1.4 2.0 -1.1 -1.4 -0.8 -1.4
Worry too long after embarrassment 2.1 3.6 13.7 -0.1 0.7 -3.7 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.8 -0.6 0.1 0.5 -0.9
Wheeze or whistling in the chest in last year 0.6 1.1 2.2 -0.8 0.2 -1.5 -1.2
Number of children fathered 0.3 0.4 0.7 -0.6 -0.4 -0.5 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.9 2.3 7.8 2.8 0.5 0.6 0.8
Age at first live birth 0.5 0.9 2.9 0.6 -0.6 1.7 -0.2
Pulse wave peak to peak time 0.3 0.4 0.9 0.1 -0.9 0.6 0.5
Health satisfaction 1.3 1.7 2.9 -1.4 -1.7 -1.0 -0.9
Shortness of breath walking on level ground 0.8 1.0 2.9 -0.8 -0.3 -0.5 -1.7
Qualifications: College or University degree 0.3 1.1 3.2 -0.0 -0.9 1.8 0.3
Eye problems/disorders: None of the above 0.2 0.2 0.8 0.3 -0.1 -0.9 0.2
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.5 -0.3 0.7 -0.5 -0.6
Emphysema/chronic bronchitis 0.9 1.0 3.9 0.5 0.2 -2.0 0.1
Medication for pain relief, constipation, heartburn 0.3 0.5 1.0 -0.5 -0.2 1.0 1.0
Neck or shoulder pain in last month 1.1 1.6 4.6 -0.1 -0.3 -2.1 -1.2
Medication: Blood pressure 0.3 0.5 0.8 -0.8 -0.9 0.8 -0.2
Angina (self-reported) 0.2 0.3 1.0 0.2 -1.0 -0.3 -0.1
Migraine (self-reported) 0.4 0.4 1.0 0.7 0.0 -1.0 0.5
Medication: Ibuprofen 1.6 2.0 5.7 0.4 1.2 -0.7 2.4
Medication: Allopurinol 0.5 0.6 1.4 -1.2 -0.3 0.7 0.7
Medication: Omeprazole 0.9 1.0 2.2 0.5 0.4 -1.5 -1.2
Medication: Seretide 50 evohaler 0.9 1.1 3.6 0.1 -0.4 -0.7 -1.9
Mean time to correctly identify matches 0.7 1.3 3.2 1.0 -0.0 1.8 1.1
Heart disease (mother) 0.3 0.4 0.8 0.9 0.5 0.7 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 0.9 0.7 1.0 -0.3 0.4
Whole body fat mass 0.2 0.8 2.5 -0.2 0.4 -1.6 -0.8
Leg fat mass (right) 0.4 1.7 4.8 -0.5 0.7 -2.2 -1.2
Arm predicted mass (right) 2.5 12.5 25.0 -4.2 -2.4 1.4 -5.0
Pulse rate, automated reading 0.7 2.4 4.8 0.0 1.7 -2.2 1.4
Alcohol intake frequency. 0.2 0.4 1.3 0.5 0.2 -1.2 -0.4
Comparative height size at age 10 0.8 4.6 15.3 -1.6 -0.6 3.9 0.6
Number of full sisters 0.4 0.4 1.0 -1.0 0.7 -0.5 0.0
Suffer from ‘nerves’ 1.2 1.9 3.3 1.8 0.8 -1.8 0.7
Overall health rating 1.8 3.8 13.1 -1.0 0.1 -3.6 -1.0
Chest pain or discomfort 0.3 0.4 0.9 -0.4 -0.9 -0.7 -0.3
Had major operations 0.9 1.1 3.5 0.3 -0.8 -0.4 -1.9
Age at last live birth 0.4 0.6 1.1 -0.6 -1.1 0.1 -1.0
Family relationship satisfaction 0.5 0.7 2.3 -0.4 0.1 -1.5 0.5
Leg pain on walking 1.3 1.6 2.1 1.4 1.3 -1.4 0.9
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 -0.3 -0.2 -0.1 -0.4
Commuting to job workplace: Car/motor vehicle 2.2 2.5 7.4 -0.0 -0.8 -1.3 -2.7
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 2.6 1.6 1.2 0.7 0.5
Medication: Aspirin 1.8 2.4 5.9 -0.2 -2.4 1.2 -1.5
Supplements: Vitamin C 0.1 0.1 0.2 0.5 0.3 -0.3 0.1
Knee pain experienced in last month 1.2 1.9 5.3 -0.0 1.3 -2.3 0.8
Hypertension (Self-reported) 0.2 0.5 1.1 -0.5 -0.2 -1.1 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.6 0.1 -1.2 1.0 -0.7
Illnesses of father: Heart disease 4.5 6.2 9.7 -3.1 -3.0 1.1 -2.2
Illnesses of siblings: Diabetes 0.5 0.6 1.7 -0.7 0.3 -0.5 -1.3
Smoking status: Previous 4.2 6.3 10.3 -3.1 -3.2 1.0 -2.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.5 -0.3 0.2 0.7 -0.3
Whole body fat-free mass 2.0 11.3 19.9 -4.0 -2.5 1.8 -4.5
Leg fat-free mass (right) 2.0 10.6 17.8 -4.0 -2.8 1.1 -4.2
Arm fat percentage (left) 0.3 1.3 4.9 -0.1 0.3 -2.2 0.2
Average weekly red wine intake 0.8 1.1 2.5 -1.3 0.4 1.6 0.3
Handedness (chirality/laterality): Left-handed 1.4 1.6 4.8 2.2 1.1 -0.6 0.4
Mood swings 3.5 6.4 12.6 2.6 2.0 -3.5 1.5
Loneliness, isolation 0.4 0.5 2.1 0.1 0.1 -1.4 0.1
Long-standing illness, disability or infirmity 0.1 0.2 0.4 0.4 0.2 -0.7 -0.3
Ever had bowel cancer screening 0.1 0.2 0.5 0.2 -0.2 -0.1 -0.7
Diabetes diagnosed by doctor 1.1 1.8 2.9 -1.3 -1.4 0.7 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 2.1 -1.4 -0.9 0.1 -1.3
Friendships satisfaction 0.2 0.3 0.7 -0.2 -0.9 -0.6 0.2
Qualifications: nursing, teaching 1.1 1.6 3.5 -0.9 -1.3 1.9 -0.8
Commuting to job workplace: Walk 2.2 2.4 6.4 0.2 1.6 -0.8 2.5
Eye problems/disorders: Cataract 0.3 0.3 0.7 -0.6 -0.0 0.8 0.5
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 0.5 0.1 -0.7 0.6
Medication for cholesterol 0.4 0.6 1.8 0.4 0.1 1.4 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 1.6 -0.5 0.6 -1.2 -1.3
Back pain experienced in last month 2.9 4.2 6.8 -2.6 -1.2 -1.5 -2.5
Mineral and other dietary supplements 2.4 3.2 5.0 -1.5 -2.2 1.9 -1.4
Breast cancer (self-reported) 0.1 0.1 0.1 0.1 -0.3 -0.4 -0.4
Asthma (self-reported) 0.2 0.4 0.7 -0.4 -0.8 0.8 0.0
Osteoporosis (self-reported) 0.7 0.9 3.2 0.0 0.5 -0.1 1.8
Osteoarthritis (self-reported) 0.4 0.5 0.8 -0.8 -0.9 -0.3 -0.7
Medication: Aspirin 1.4 1.8 4.7 -0.5 -2.2 0.7 -1.3
Medication: Gliclazide 0.2 0.3 0.5 -0.5 -0.6 0.0 -0.7
Illnesses of father: None of the above (group 1) 1.1 1.3 2.2 1.5 1.0 0.4 1.4
Smoking status: Current 1.1 1.7 4.0 -1.3 1.0 -2.0 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 3.6 1.9 0.1 0.2 1.7
Whole body water mass 2.0 11.3 20.3 -3.9 -2.5 1.7 -4.5
Leg predicted mass (right) 2.0 10.7 18.1 -4.0 -2.7 1.1 -4.2
Arm fat mass (left) 0.3 1.4 3.7 -0.8 -0.1 -1.9 -1.1
Number of self-reported non-cancer illnesses 0.7 1.3 2.5 -0.6 -0.8 -1.3 -1.6
Average weekly champagne plus white wine intake 0.2 0.3 0.6 0.8 0.6 0.0 0.6
Miserableness 5.2 9.0 33.1 0.7 1.3 -5.8 -0.9
Guilty feelings 4.2 6.3 19.5 0.9 2.2 -4.4 0.3
Wears glasses or contact lenses 0.1 0.1 0.2 -0.5 0.2 0.4 0.2
Ever taken oral contraceptive pill 0.8 0.8 2.0 -1.4 -1.1 0.1 -0.4
Hearing aid user 1.6 1.8 2.9 -0.6 1.4 -1.7 -1.4
Mother’s age at death 0.8 1.0 1.5 -1.0 -0.5 1.1 -1.2
Financial situation satisfaction 1.1 1.3 3.3 0.1 0.6 -1.8 1.3
Tinnitus: Yes, now most or all of the time 0.9 1.1 1.8 -0.9 0.6 -1.3 -1.2
Commuting to job workplace: Public transport 1.1 1.3 3.1 -0.3 -0.2 1.5 1.8
Eye problems/disorders: Glaucoma 0.6 0.7 0.9 0.8 0.8 -0.7 -1.0
Medication: Blood pressure 0.5 0.9 1.4 -1.0 -1.0 -0.2 -1.2
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.0 0.3 0.4 -1.0 -0.1
Supplements: Fish oil (including cod liver oil) 2.0 2.7 4.7 1.2 1.8 -2.2 1.1
High cholesterol (Self-reported) 0.1 0.2 0.4 -0.1 -0.4 -0.6 -0.6
Medication: Bendroflumethiazide 0.1 0.2 0.3 0.3 0.6 -0.1 0.6
Medication: Paracetamol 0.2 0.3 0.9 -0.1 0.4 -1.0 -0.2
Medication: Lisinopril 1.7 2.2 4.8 -1.4 -1.0 -0.9 -2.2
Medication: Atorvastatin 0.9 1.1 4.0 2.0 0.4 -0.2 -0.3
Illnesses of father: High blood pressure 0.2 0.3 0.8 0.1 -0.4 -0.9 0.4
Alcohol drinker status: Never 1.2 1.5 2.7 1.6 1.0 -0.2 1.4
Ever smoked 1.2 2.2 5.6 -2.4 -0.1 -1.4 -1.0
Basal metabolic rate 1.5 8.1 15.4 -3.4 -2.1 1.1 -3.9
Leg fat percentage (left) 1.5 5.3 13.4 1.5 2.3 -3.7 0.5
Arm fat-free mass (left) 1.6 7.9 19.3 -3.0 -1.7 0.8 -4.4
Number of operations (self-reported) 0.4 0.6 1.2 -1.1 -0.5 -0.3 -1.0
Average weekly beer plus cider intake 0.4 0.5 1.4 -0.0 -0.8 0.1 1.2
Irritability 4.3 7.3 16.8 2.2 2.7 -4.1 0.6
Risk taking 1.3 1.9 2.7 -1.2 -1.3 1.6 -1.3
Ever had prostate specific antigen (PSA) test 9.6 11.1 16.7 -2.8 -4.1 4.0 -1.8
Fractured/broken bones in last 5 years 0.1 0.1 0.2 0.1 0.3 -0.1 0.4
Age started oral contraceptive pill 3.8 4.7 7.1 2.4 2.7 -2.3 0.8
Diastolic blood pressure, automated reading 4.2 13.0 17.7 4.1 3.7 -4.2 2.0
Ever depressed for a whole week 2.5 3.0 4.9 -1.4 -2.2 -0.6 -2.2
Unable to work because of sickness or disability 1.2 1.6 3.7 -1.2 0.5 -0.9 -1.9
Commuting to job workplace: Cycle 0.1 0.2 0.5 -0.2 0.7 0.2 -0.1
Myopia 1.3 1.9 3.3 1.4 1.8 -1.4 0.6
Vascular/heart problems diagnosed by doctor 0.3 0.9 2.0 0.8 0.5 0.8 1.4
Cholesterol lowering medication 1.3 2.0 4.4 0.2 -0.2 -2.1 -1.8
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.3 1.1 1.0 -1.5 -0.3
Pain experienced in last month 1.4 2.4 6.8 1.0 0.5 2.6 1.2
Supplements: Calcium 0.7 0.8 1.7 1.3 0.7 -0.4 0.9
Basal cell carcinoma (self-reported) 0.7 0.9 2.4 -0.2 -0.4 1.6 0.9
Heart attack/myocardial infarction (self-reported) 2.4 3.1 4.5 -2.1 -2.1 1.4 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 1.1 -1.0 -1.1 0.8 -0.2
Heart disease (siblings) 0.9 1.1 2.3 -1.5 0.2 -0.2 -1.4
Alcohol drinker status: Previous 0.1 0.1 0.2 0.4 0.5 -0.3 0.0
Pack years of smoking 1.9 2.8 5.3 1.1 2.3 -2.0 -0.6
Impedance of whole body 3.7 18.7 39.7 5.0 3.2 0.2 6.3
Leg fat mass (left) 0.5 2.0 5.3 -0.5 0.7 -2.3 -1.3
Arm predicted mass (left) 1.5 7.7 18.3 -3.0 -1.6 0.9 -4.3