Hub : Genes

PAFAH1B1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1662	0.0427	1.4e-06	0.054	NA	0.038	NA	0.041	4.5e-06	NA	1.2e-04	NA	6.5e-05
2	ROSMAP	Brain Pre-frontal Cortex	0.0963	0.0267	2.6e-06	0.033	0.060	0.064	0.063	0.063	4.1e-05	3.1e-08	1.1e-08	1.4e-08	1.4e-08
3	YFS	Blood	0.1339	0.0234	0.0e+00	0.099	0.076	0.093	0.082	0.068	1.2e-30	1.4e-23	6.1e-29	1.8e-25	3.5e-21
4	TCGA	Colon Adenocarcinoma	0.1130	0.0590	3.1e-03	0.001	0.036	0.015	NA	0.013	2.7e-01	3.6e-03	4.1e-02	NA	5.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.6	2.6	6.8	-0.7	-2.6	0.6	-1.7
Bipolar Disorder or Schizophrenia	0.2	0.5	1.5	0.2	-1.2	-0.5	-0.3
Depressed Affect (Nagel 2018)	2.7	5.7	21.3	0.8	-0.2	-4.6	-1.0
Depression (Nagel 2018)	1.3	2.0	7.3	-0.1	-0.4	-2.7	-0.7
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.1	0.7	-0.6	1.1	-0.4
Neuroticism (Nagel 2018)	3.7	8.7	28.9	2.2	1.1	-5.4	0.1
Schizophrenia (2018)	0.4	0.8	1.6	0.9	0.6	-1.3	0.8
Schizophrenia vs Biploar Disorder	2.5	3.2	3.6	1.6	1.9	-1.9	1.8
Worry (Nagel 2018)	2.4	5.1	10.0	2.8	1.4	-3.2	0.6
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	-0.1	0.4	-0.3	-0.1
Alzheimer’s Disease (in father)	2.9	3.1	4.7	1.8	2.2	-1.7	1.3
Alzheimer’s Disease (including proxy)	1.2	1.8	3.3	1.2	1.8	-1.0	1.2
Crohns Disease (2017)	3.5	7.6	10.7	-3.3	-2.7	1.7	-3.1
Irritable Bowel Disease (IBD)	2.2	5.3	10.2	-3.2	-1.9	1.0	-2.5
Ulcerative Colitis (UC)	0.8	1.4	3.6	-1.9	-0.7	0.4	-1.2
Major Depression (MDD)	2.3	2.8	5.6	-1.3	-2.4	1.1	-1.7
Reaction Time	0.6	1.1	3.8	-0.2	-0.4	1.9	0.7
Verbal and Numeric Reasoning (VNR)	0.5	1.2	3.5	0.7	-1.9	0.7	-0.5
Breast Cancer	1.8	4.3	10.1	1.7	2.0	-3.2	-0.5
Ovarian Cancer	0.3	0.5	0.8	-0.9	0.6	0.7	0.3
Prostate Cancer	0.2	0.3	0.9	0.4	0.3	-0.9	-0.3
Age at First Birth	1.5	2.2	3.2	1.7	1.8	-1.3	1.1
Bipolar Disorder (2011)	0.1	0.1	0.3	0.0	0.0	0.0	0.5
Body Mass Index (BMI) (2010)	0.8	1.2	1.5	-1.2	-1.1	0.7	-1.2
Coronary Artery Disease (CAD)	2.7	3.2	6.1	-2.5	-2.2	0.2	-1.3
Crohns Disease (2012)	1.7	2.7	3.1	-1.7	-1.8	1.5	-1.6
Mean Putamen Volume	2.1	2.4	4.0	-1.3	-2.0	1.9	-0.5
Fasting Glucose	0.3	0.4	0.8	-0.5	-0.2	0.9	-0.7
HbA1C	0.3	0.4	0.7	-0.8	-0.3	-0.1	0.8
HDL Cholesterol	0.6	0.9	1.7	1.2	0.3	-1.3	-0.7
LDL Cholesterol	0.2	0.3	0.5	0.4	-0.7	0.7	0.3
Lupus	0.2	0.3	0.6	0.8	0.3	-0.1	0.6
Neuroticism (2016)	3.7	5.4	14.5	-0.2	-0.1	-3.8	-2.6
Primary Biliary Cirrhosis	1.0	1.4	2.0	-1.2	-1.4	0.6	-1.4
Rheumatoid Arthritis	0.4	0.5	1.5	-0.4	0.5	0.4	1.2
Schizophrenia (2014)	0.5	1.1	3.3	1.0	-0.2	-1.8	0.4
Triglycerides	0.7	1.2	3.1	-1.1	-0.7	0.1	-1.8
Type 2 Diabetes (T2D) (2012)	1.7	1.9	2.9	-1.6	-1.7	1.0	-1.1
Ulcerative Colitis	1.7	2.4	3.3	-1.8	-1.7	1.7	-0.8
Blood Eosinophil Count	0.4	3.4	6.1	-2.5	-2.1	1.7	0.5
Blood Platelet Count	2.2	25.7	34.6	5.9	5.4	-3.6	5.1
Blood Red Count	0.5	4.6	8.4	2.1	2.9	-1.1	2.1
Blood White Count	1.0	7.6	16.1	1.6	3.4	-0.2	4.0
Heel T-Score	2.0	15.6	22.0	-4.3	-4.7	2.3	-4.0
BMI	0.9	5.1	8.7	-2.7	-1.7	-1.0	-3.0
Height	0.2	4.4	16.3	0.3	0.9	4.0	0.7
Waist Hip Ratio (WHR)	0.4	1.6	5.4	-2.3	-0.5	0.8	0.5
Systolic Blood Pressure	5.4	27.3	35.6	6.0	5.3	-5.8	3.3
Smoking Status	2.5	5.9	14.3	-3.8	-1.7	-1.3	-2.2
Allergy or Eczema	0.3	0.8	1.9	-1.4	-0.6	-0.8	-0.5
Cardiovascular Disease	0.8	2.7	5.2	-1.6	-1.2	-1.2	-2.3
Hypothyroidism (self reported)	0.3	0.6	1.1	1.0	0.6	-1.1	-0.2
Respiratory disease	0.1	0.2	0.5	0.7	-0.4	-0.6	0.1
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.8	-1.1	-0.9	0.6	-1.9
Lung FEV1/FVC ratio	0.1	0.3	0.8	-0.9	-0.1	-0.1	0.5
Lung FVC	0.3	1.5	3.0	1.7	-0.7	0.9	1.4
Neuroticism	3.8	9.2	27.8	2.0	2.1	-5.3	0.8
Chronotype (morning person)	0.8	1.9	5.9	2.4	1.3	-0.4	-0.2
Hair Pigment	0.0	0.6	2.3	-1.5	-0.5	-0.0	-0.2
Tanning	0.1	0.7	1.9	0.4	1.4	0.6	0.5
Hand grip strength (left)	0.6	1.6	2.9	-0.9	-1.7	1.3	-1.0
Number of treatments/medications taken	0.3	0.5	1.6	-0.1	-0.3	-1.2	-0.7
Average weekly spirits intake	0.0	0.0	0.1	-0.2	-0.2	-0.0	0.1
Sensitivity / hurt feelings	1.8	3.0	10.3	0.7	1.2	-3.2	0.1
Frequency of depressed mood in last 2 weeks	3.1	4.3	15.8	-0.3	0.7	-4.0	-1.0
Hearing difficulty/problems: Yes	1.8	2.7	5.1	0.8	0.6	-2.2	-2.3
Relative age of first facial hair	0.3	0.7	1.7	0.9	1.3	-0.7	0.0
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.0	1.1	1.2	-1.4	-0.6
Ever used hormone-replacement therapy (HRT)	2.4	3.0	4.8	1.9	2.2	-1.8	0.6
Ever had hysterectomy (womb removed)	2.3	2.6	6.8	1.2	1.3	-2.6	-0.5
Systolic blood pressure, automated reading	6.2	18.0	23.5	4.8	4.7	-4.4	2.7
Eye problems/disorders: Diabetes related eye disease	4.9	5.3	8.0	-2.1	-2.8	2.1	-2.1
Angina	0.2	0.2	0.7	0.2	-0.9	-0.2	0.0
Medication for hormone replacement therapy	2.1	2.4	6.4	1.3	1.1	-0.4	2.5
Vitamin and mineral supplements	0.2	0.3	0.5	-0.5	-0.4	0.4	-0.7
Supplements: Zinc	1.3	1.4	2.7	1.6	1.2	-1.1	-0.1
Medication: Co-codamol	0.8	1.0	3.1	-0.5	-0.5	-1.8	-0.5
Medication: Metformin	1.0	1.4	4.2	-0.7	-0.6	0.7	-2.0
Diabetes (father)	1.6	1.9	3.4	1.1	1.3	-1.9	-1.2
Diabetes (mother)	0.6	0.7	1.6	0.3	1.3	0.1	1.1
Severe depression (siblings)	1.3	1.5	4.2	-1.2	0.5	-2.0	0.1
Pack years adult smoking proportion	1.8	2.7	5.6	0.7	2.0	-2.4	-0.8
Impedance of leg (right)	3.6	17.2	29.9	4.9	3.8	0.1	5.5
Leg fat-free mass (left)	1.9	10.2	16.4	-3.9	-2.8	1.2	-4.0
Trunk fat percentage	0.5	2.1	3.8	1.2	1.3	-1.9	1.3
Hand grip strength (right)	0.1	0.2	0.5	-0.3	-0.7	-0.1	-0.2
Townsend deprivation index at recruitment	0.9	1.3	3.8	-0.2	1.2	-2.0	-0.1
Current tobacco smoking	1.0	1.6	3.9	-1.2	1.0	-2.0	-0.3
Average weekly fortified wine intake	1.9	2.2	5.2	-0.8	-1.7	2.3	-0.5
Maternal smoking around birth	0.2	0.3	0.6	-0.5	0.3	-0.3	-0.8
Fed-up feelings	2.5	4.5	17.0	-0.7	0.2	-4.1	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.7	5.3	-0.9	-0.7	-2.3	-0.2
Relative age voice broke	0.3	0.5	1.1	-0.3	0.5	1.1	-0.8
Taking other prescription medications	1.3	1.9	6.4	0.7	-0.3	-2.5	-0.9
Age when periods started (menarche)	0.1	0.2	0.4	0.1	-0.5	0.6	0.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.0	0.5	1.4	-0.8	0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.6	7.4	-1.3	-2.1	-1.0	-2.7
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	3.4	-1.6	-1.8	1.3	0.5
Qualifications: CSEs or equivalent	0.2	0.3	1.0	-0.1	0.2	-1.0	-0.5
Serious illness, injury or assault to yourself	0.2	0.2	0.7	0.2	-0.1	0.8	0.3
High blood pressure	0.2	0.5	1.0	-0.4	-0.1	-0.9	-1.0
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.0	-1.0	-0.7	-1.0	-0.7
Multivitamins +/- minerals	0.3	0.4	1.0	0.1	0.8	0.4	1.0
Stomach or abdominal pain in last month	2.2	2.8	5.6	-1.8	-0.6	-2.4	-1.4
Supplements: Glucosamine	0.3	0.4	1.1	-0.2	-0.4	1.0	0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.1	1.0	0.6	-0.7	0.3
Medication: Atenolol	0.6	0.7	1.3	-1.1	-0.5	-0.5	-1.1
Medication: Levothyroxine sodium	0.0	0.0	0.1	0.2	0.2	-0.1	-0.3
Sitting height	0.3	2.1	8.4	0.1	-0.3	2.9	-0.3
Chronic bronchitis/emphysema (father)	1.1	1.3	3.7	-1.2	-0.2	0.1	-1.9
High blood pressure (mother)	0.1	0.1	0.4	0.2	0.1	-0.6	-0.1
Body mass index (BMI)	1.0	4.4	8.1	-1.7	-0.8	-2.4	-2.8
Impedance of leg (left)	3.9	18.8	30.7	5.2	4.2	-0.4	5.5
Leg predicted mass (left)	1.9	10.1	16.2	-3.9	-2.8	1.2	-4.0
Trunk fat mass	0.1	0.6	1.9	0.1	0.7	-1.4	-0.0
Waist circumference	0.5	1.8	3.6	-1.4	-0.1	-1.9	-1.3
Number of incorrect matches in round	1.4	2.3	3.1	1.8	1.6	-1.3	1.4
Past tobacco smoking	3.1	5.7	13.2	3.6	2.3	-0.1	2.1
Alcohol usually taken with meals	0.7	1.2	2.5	-1.6	-0.6	1.3	-0.3
Nervous feelings	1.8	3.4	9.2	1.7	1.0	-3.0	0.6
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	5.9	-1.4	-1.6	-2.4	-0.8
Hearing difficulty/problems with background noise	4.8	7.6	17.9	-1.2	0.3	-4.2	-3.3
Hair/balding pattern: Pattern 2	0.5	0.6	2.0	1.4	0.4	-0.2	0.4
Had menopause	1.0	1.2	2.4	1.1	1.1	-1.5	0.1
Had other major operations	0.2	0.2	0.4	-0.6	0.3	-0.4	0.5
Forced vital capacity (FVC)	0.7	2.8	9.2	0.0	-1.0	3.0	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	7.3	-0.7	-1.7	-1.5	-2.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.4	-0.1	-1.5	-1.0	0.3
Qualifications: None of the above	0.8	1.7	2.9	0.9	1.4	-1.7	1.1
Financial difficulties in last 2 years	0.6	0.9	3.0	-0.5	-0.5	-1.7	0.0
Mouth/teeth dental problems	0.5	0.8	3.0	1.7	-0.5	0.2	-0.1
Heart attack	2.1	2.7	3.9	-2.0	-1.9	1.3	-1.3
Allergy	0.6	1.3	2.2	1.4	1.5	0.2	1.1
Pain all over the body in last month	1.6	1.7	3.3	1.8	1.3	-1.0	1.0
Diabetes (self-reported)	1.7	2.7	6.8	-1.2	-1.5	0.3	-2.6
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.7	0.6	1.0	-1.6	-1.3
Medication: Ramipril	0.4	0.6	1.3	-1.1	-0.8	-0.5	0.2
Medication: Simvastatin	0.3	0.5	1.7	0.4	-0.2	-1.3	-0.4
Fluid intelligence score	0.3	0.6	1.5	1.2	-1.0	0.1	-0.2
Illnesses of siblings	0.5	0.7	1.5	1.2	0.1	0.5	0.9
Neuroticism score	4.0	8.4	27.1	1.3	2.1	-5.2	0.6
Weight	0.5	2.6	6.1	-1.9	-0.8	-0.5	-2.5
Impedance of arm (right)	3.7	17.1	39.4	4.7	2.6	0.3	6.3
Arm fat percentage (right)	0.4	1.6	5.8	0.3	0.7	-2.4	0.2
Trunk fat-free mass	1.8	10.4	17.9	-3.8	-2.2	2.1	-4.2
Hip circumference	0.3	1.5	3.6	0.1	-0.2	-1.9	-1.5
Time employed in main current job	1.0	1.2	1.9	1.4	0.0	1.3	1.1
Alcohol intake versus 10 years previously	1.5	2.3	3.9	-1.4	-2.0	0.7	-1.7
Father’s age at death	3.1	4.2	8.4	1.4	2.9	-0.9	2.4
Worrier / anxious feelings	1.1	2.2	7.8	0.3	0.6	-2.8	-0.6
Frequency of tiredness / lethargy in last 2 weeks	5.4	8.8	33.5	-0.5	0.4	-5.8	-1.1
Falls in the last year	0.7	0.9	3.3	-0.2	-0.3	0.3	-1.8
Hair/balding pattern: Pattern 3	1.4	2.2	3.8	1.0	1.7	-0.9	1.9
Number of live births	1.4	2.0	3.8	-1.5	-1.5	0.2	-1.9
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	4.2	0.2	-0.6	2.1	1.5
Pulse rate	1.7	2.8	4.7	1.1	1.6	-1.7	2.2
Happiness	0.8	1.0	1.8	-1.3	-0.7	-1.4	-0.0
Noisy workplace	0.5	0.6	1.2	0.5	1.1	-0.8	0.3
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.3	1.1	0.8	-0.6	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.5	-0.4	-0.0	-0.2	-0.7
Mouth/teeth dental problems: Dentures	0.6	1.1	2.2	-1.5	1.0	0.6	0.9
Asthma	0.4	0.9	1.8	-0.7	-1.3	1.0	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	5.8	1.2	1.1	-0.2	2.4
Medication: Cholesterol lowering	0.6	0.9	2.2	0.2	-1.2	0.3	-1.5
Depression (self-reported)	0.9	1.0	1.7	-0.9	-1.3	-0.2	-1.3
Medication: Lansoprazole	0.5	0.6	1.4	-1.2	-0.6	0.8	-0.0
Prospective memory result	0.5	0.6	1.5	-0.9	1.2	0.1	0.5
Lung cancer (father)	1.6	1.8	2.6	-1.6	-0.6	1.6	-1.4
Illnesses of mother	0.4	0.5	1.2	-0.5	-0.6	-1.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	3.0	0.2	-0.4	1.7	1.2
Pulse wave Arterial Stiffness index	0.3	0.3	0.9	-0.1	1.0	-0.2	-0.5
Impedance of arm (left)	3.4	15.9	42.7	4.1	1.9	1.0	6.5
Arm fat mass (right)	0.3	1.3	3.2	-0.8	-0.1	-1.8	-1.1
Trunk predicted mass	1.8	10.0	17.1	-3.7	-2.2	2.2	-4.1
Standing height	0.4	4.1	15.9	-0.7	-0.3	4.0	0.2
Length of working week for main job	1.0	1.1	2.9	-0.8	-1.7	0.3	-1.0
Exposure to tobacco smoke at home	0.3	0.4	0.5	0.6	-0.4	0.7	-0.7
Breastfed as a baby	0.6	0.7	1.2	-1.0	-1.1	0.7	-0.1
Tense / ‘highly strung’	0.4	0.6	1.3	0.5	0.3	-1.1	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.6	7.5	-2.7	-1.5	0.2	-2.1
Hair/balding pattern: Pattern 4	0.3	0.7	2.2	1.5	-0.8	-0.1	-0.1
Birth weight of first child	3.3	6.0	16.4	1.3	2.1	-4.0	-1.2
Peak expiratory flow (PEF)	0.9	2.0	4.8	2.2	1.3	-0.4	1.1
Pulse wave reflection index	0.7	0.9	1.6	1.2	1.3	-0.4	-0.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.0	-1.0	-0.8	0.1	0.1
Loud music exposure frequency	1.2	1.3	3.7	0.2	1.1	-1.9	-0.3
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.4	1.6	0.8	-0.4	1.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.6	-0.2	-0.3	0.3	0.8
Blood clot in the leg (DVT)	0.5	0.6	1.0	-0.7	-1.0	1.0	-0.1
Medication: Paracetamol	0.9	1.4	3.0	0.8	1.2	-1.7	-0.8
Headache pain in last month	1.1	1.8	4.9	0.6	0.6	-2.2	-1.3
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	3.8	1.5	1.9	-1.1	1.9
Glaucoma (self-reported)	0.9	1.1	2.2	1.1	1.5	-0.9	-0.0
Gout (self-reported)	0.8	1.1	2.8	0.2	1.1	-0.7	1.7
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	0.7	0.3	-0.3	-0.1
Medication: Amlodipine	0.2	0.2	0.5	-0.5	-0.7	-0.0	-0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	-0.0	0.1	-0.1	0.6
Birth weight	0.5	1.2	3.6	1.9	-0.5	-0.6	-0.6
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.8	0.1	-0.2	-1.2	-1.3
High blood pressure (siblings)	0.2	0.3	0.6	0.1	0.5	-0.8	0.7
Forced vital capacity (FVC), Best measure	0.4	1.4	3.9	0.7	0.0	2.0	1.0
Body fat percentage	0.6	2.4	5.2	1.2	1.5	-2.3	1.0
Leg fat percentage (right)	1.4	5.1	12.1	1.4	2.4	-3.5	0.6
Arm fat-free mass (right)	2.4	12.4	24.5	-4.1	-2.5	1.4	-5.0
Exposure to tobacco smoke outside home	3.8	5.0	6.8	2.0	2.5	-2.6	1.8
Comparative body size at age 10	0.2	0.4	0.6	0.8	-0.5	-0.6	-0.7
Number of full brothers	1.1	1.4	2.0	-1.1	-1.4	-0.8	-1.4
Worry too long after embarrassment	2.1	3.6	13.7	-0.1	0.7	-3.7	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.6	0.1	0.5	-0.9
Wheeze or whistling in the chest in last year	0.6	1.1	2.2	-0.8	0.2	-1.5	-1.2
Number of children fathered	0.3	0.4	0.7	-0.6	-0.4	-0.5	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.3	7.8	2.8	0.5	0.6	0.8
Age at first live birth	0.5	0.9	2.9	0.6	-0.6	1.7	-0.2
Pulse wave peak to peak time	0.3	0.4	0.9	0.1	-0.9	0.6	0.5
Health satisfaction	1.3	1.7	2.9	-1.4	-1.7	-1.0	-0.9
Shortness of breath walking on level ground	0.8	1.0	2.9	-0.8	-0.3	-0.5	-1.7
Qualifications: College or University degree	0.3	1.1	3.2	-0.0	-0.9	1.8	0.3
Eye problems/disorders: None of the above	0.2	0.2	0.8	0.3	-0.1	-0.9	0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.5	-0.3	0.7	-0.5	-0.6
Emphysema/chronic bronchitis	0.9	1.0	3.9	0.5	0.2	-2.0	0.1
Medication for pain relief, constipation, heartburn	0.3	0.5	1.0	-0.5	-0.2	1.0	1.0
Neck or shoulder pain in last month	1.1	1.6	4.6	-0.1	-0.3	-2.1	-1.2
Medication: Blood pressure	0.3	0.5	0.8	-0.8	-0.9	0.8	-0.2
Angina (self-reported)	0.2	0.3	1.0	0.2	-1.0	-0.3	-0.1
Migraine (self-reported)	0.4	0.4	1.0	0.7	0.0	-1.0	0.5
Medication: Ibuprofen	1.6	2.0	5.7	0.4	1.2	-0.7	2.4
Medication: Allopurinol	0.5	0.6	1.4	-1.2	-0.3	0.7	0.7
Medication: Omeprazole	0.9	1.0	2.2	0.5	0.4	-1.5	-1.2
Medication: Seretide 50 evohaler	0.9	1.1	3.6	0.1	-0.4	-0.7	-1.9
Mean time to correctly identify matches	0.7	1.3	3.2	1.0	-0.0	1.8	1.1
Heart disease (mother)	0.3	0.4	0.8	0.9	0.5	0.7	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.9	0.7	1.0	-0.3	0.4
Whole body fat mass	0.2	0.8	2.5	-0.2	0.4	-1.6	-0.8
Leg fat mass (right)	0.4	1.7	4.8	-0.5	0.7	-2.2	-1.2
Arm predicted mass (right)	2.5	12.5	25.0	-4.2	-2.4	1.4	-5.0
Pulse rate, automated reading	0.7	2.4	4.8	0.0	1.7	-2.2	1.4
Alcohol intake frequency.	0.2	0.4	1.3	0.5	0.2	-1.2	-0.4
Comparative height size at age 10	0.8	4.6	15.3	-1.6	-0.6	3.9	0.6
Number of full sisters	0.4	0.4	1.0	-1.0	0.7	-0.5	0.0
Suffer from ‘nerves’	1.2	1.9	3.3	1.8	0.8	-1.8	0.7
Overall health rating	1.8	3.8	13.1	-1.0	0.1	-3.6	-1.0
Chest pain or discomfort	0.3	0.4	0.9	-0.4	-0.9	-0.7	-0.3
Had major operations	0.9	1.1	3.5	0.3	-0.8	-0.4	-1.9
Age at last live birth	0.4	0.6	1.1	-0.6	-1.1	0.1	-1.0
Family relationship satisfaction	0.5	0.7	2.3	-0.4	0.1	-1.5	0.5
Leg pain on walking	1.3	1.6	2.1	1.4	1.3	-1.4	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.3	-0.2	-0.1	-0.4
Commuting to job workplace: Car/motor vehicle	2.2	2.5	7.4	-0.0	-0.8	-1.3	-2.7
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.6	1.6	1.2	0.7	0.5
Medication: Aspirin	1.8	2.4	5.9	-0.2	-2.4	1.2	-1.5
Supplements: Vitamin C	0.1	0.1	0.2	0.5	0.3	-0.3	0.1
Knee pain experienced in last month	1.2	1.9	5.3	-0.0	1.3	-2.3	0.8
Hypertension (Self-reported)	0.2	0.5	1.1	-0.5	-0.2	-1.1	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.6	0.1	-1.2	1.0	-0.7
Illnesses of father: Heart disease	4.5	6.2	9.7	-3.1	-3.0	1.1	-2.2
Illnesses of siblings: Diabetes	0.5	0.6	1.7	-0.7	0.3	-0.5	-1.3
Smoking status: Previous	4.2	6.3	10.3	-3.1	-3.2	1.0	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.3	0.2	0.7	-0.3
Whole body fat-free mass	2.0	11.3	19.9	-4.0	-2.5	1.8	-4.5
Leg fat-free mass (right)	2.0	10.6	17.8	-4.0	-2.8	1.1	-4.2
Arm fat percentage (left)	0.3	1.3	4.9	-0.1	0.3	-2.2	0.2
Average weekly red wine intake	0.8	1.1	2.5	-1.3	0.4	1.6	0.3
Handedness (chirality/laterality): Left-handed	1.4	1.6	4.8	2.2	1.1	-0.6	0.4
Mood swings	3.5	6.4	12.6	2.6	2.0	-3.5	1.5
Loneliness, isolation	0.4	0.5	2.1	0.1	0.1	-1.4	0.1
Long-standing illness, disability or infirmity	0.1	0.2	0.4	0.4	0.2	-0.7	-0.3
Ever had bowel cancer screening	0.1	0.2	0.5	0.2	-0.2	-0.1	-0.7
Diabetes diagnosed by doctor	1.1	1.8	2.9	-1.3	-1.4	0.7	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.1	-1.4	-0.9	0.1	-1.3
Friendships satisfaction	0.2	0.3	0.7	-0.2	-0.9	-0.6	0.2
Qualifications: nursing, teaching	1.1	1.6	3.5	-0.9	-1.3	1.9	-0.8
Commuting to job workplace: Walk	2.2	2.4	6.4	0.2	1.6	-0.8	2.5
Eye problems/disorders: Cataract	0.3	0.3	0.7	-0.6	-0.0	0.8	0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	0.5	0.1	-0.7	0.6
Medication for cholesterol	0.4	0.6	1.8	0.4	0.1	1.4	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.6	-0.5	0.6	-1.2	-1.3
Back pain experienced in last month	2.9	4.2	6.8	-2.6	-1.2	-1.5	-2.5
Mineral and other dietary supplements	2.4	3.2	5.0	-1.5	-2.2	1.9	-1.4
Breast cancer (self-reported)	0.1	0.1	0.1	0.1	-0.3	-0.4	-0.4
Asthma (self-reported)	0.2	0.4	0.7	-0.4	-0.8	0.8	0.0
Osteoporosis (self-reported)	0.7	0.9	3.2	0.0	0.5	-0.1	1.8
Osteoarthritis (self-reported)	0.4	0.5	0.8	-0.8	-0.9	-0.3	-0.7
Medication: Aspirin	1.4	1.8	4.7	-0.5	-2.2	0.7	-1.3
Medication: Gliclazide	0.2	0.3	0.5	-0.5	-0.6	0.0	-0.7
Illnesses of father: None of the above (group 1)	1.1	1.3	2.2	1.5	1.0	0.4	1.4
Smoking status: Current	1.1	1.7	4.0	-1.3	1.0	-2.0	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.6	1.9	0.1	0.2	1.7
Whole body water mass	2.0	11.3	20.3	-3.9	-2.5	1.7	-4.5
Leg predicted mass (right)	2.0	10.7	18.1	-4.0	-2.7	1.1	-4.2
Arm fat mass (left)	0.3	1.4	3.7	-0.8	-0.1	-1.9	-1.1
Number of self-reported non-cancer illnesses	0.7	1.3	2.5	-0.6	-0.8	-1.3	-1.6
Average weekly champagne plus white wine intake	0.2	0.3	0.6	0.8	0.6	0.0	0.6
Miserableness	5.2	9.0	33.1	0.7	1.3	-5.8	-0.9
Guilty feelings	4.2	6.3	19.5	0.9	2.2	-4.4	0.3
Wears glasses or contact lenses	0.1	0.1	0.2	-0.5	0.2	0.4	0.2
Ever taken oral contraceptive pill	0.8	0.8	2.0	-1.4	-1.1	0.1	-0.4
Hearing aid user	1.6	1.8	2.9	-0.6	1.4	-1.7	-1.4
Mother’s age at death	0.8	1.0	1.5	-1.0	-0.5	1.1	-1.2
Financial situation satisfaction	1.1	1.3	3.3	0.1	0.6	-1.8	1.3
Tinnitus: Yes, now most or all of the time	0.9	1.1	1.8	-0.9	0.6	-1.3	-1.2
Commuting to job workplace: Public transport	1.1	1.3	3.1	-0.3	-0.2	1.5	1.8
Eye problems/disorders: Glaucoma	0.6	0.7	0.9	0.8	0.8	-0.7	-1.0
Medication: Blood pressure	0.5	0.9	1.4	-1.0	-1.0	-0.2	-1.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.0	0.3	0.4	-1.0	-0.1
Supplements: Fish oil (including cod liver oil)	2.0	2.7	4.7	1.2	1.8	-2.2	1.1
High cholesterol (Self-reported)	0.1	0.2	0.4	-0.1	-0.4	-0.6	-0.6
Medication: Bendroflumethiazide	0.1	0.2	0.3	0.3	0.6	-0.1	0.6
Medication: Paracetamol	0.2	0.3	0.9	-0.1	0.4	-1.0	-0.2
Medication: Lisinopril	1.7	2.2	4.8	-1.4	-1.0	-0.9	-2.2
Medication: Atorvastatin	0.9	1.1	4.0	2.0	0.4	-0.2	-0.3
Illnesses of father: High blood pressure	0.2	0.3	0.8	0.1	-0.4	-0.9	0.4
Alcohol drinker status: Never	1.2	1.5	2.7	1.6	1.0	-0.2	1.4
Ever smoked	1.2	2.2	5.6	-2.4	-0.1	-1.4	-1.0
Basal metabolic rate	1.5	8.1	15.4	-3.4	-2.1	1.1	-3.9
Leg fat percentage (left)	1.5	5.3	13.4	1.5	2.3	-3.7	0.5
Arm fat-free mass (left)	1.6	7.9	19.3	-3.0	-1.7	0.8	-4.4
Number of operations (self-reported)	0.4	0.6	1.2	-1.1	-0.5	-0.3	-1.0
Average weekly beer plus cider intake	0.4	0.5	1.4	-0.0	-0.8	0.1	1.2
Irritability	4.3	7.3	16.8	2.2	2.7	-4.1	0.6
Risk taking	1.3	1.9	2.7	-1.2	-1.3	1.6	-1.3
Ever had prostate specific antigen (PSA) test	9.6	11.1	16.7	-2.8	-4.1	4.0	-1.8
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.1	0.3	-0.1	0.4
Age started oral contraceptive pill	3.8	4.7	7.1	2.4	2.7	-2.3	0.8
Diastolic blood pressure, automated reading	4.2	13.0	17.7	4.1	3.7	-4.2	2.0
Ever depressed for a whole week	2.5	3.0	4.9	-1.4	-2.2	-0.6	-2.2
Unable to work because of sickness or disability	1.2	1.6	3.7	-1.2	0.5	-0.9	-1.9
Commuting to job workplace: Cycle	0.1	0.2	0.5	-0.2	0.7	0.2	-0.1
Myopia	1.3	1.9	3.3	1.4	1.8	-1.4	0.6
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.0	0.8	0.5	0.8	1.4
Cholesterol lowering medication	1.3	2.0	4.4	0.2	-0.2	-2.1	-1.8
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.3	1.1	1.0	-1.5	-0.3
Pain experienced in last month	1.4	2.4	6.8	1.0	0.5	2.6	1.2
Supplements: Calcium	0.7	0.8	1.7	1.3	0.7	-0.4	0.9
Basal cell carcinoma (self-reported)	0.7	0.9	2.4	-0.2	-0.4	1.6	0.9
Heart attack/myocardial infarction (self-reported)	2.4	3.1	4.5	-2.1	-2.1	1.4	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.1	-1.0	-1.1	0.8	-0.2
Heart disease (siblings)	0.9	1.1	2.3	-1.5	0.2	-0.2	-1.4
Alcohol drinker status: Previous	0.1	0.1	0.2	0.4	0.5	-0.3	0.0
Pack years of smoking	1.9	2.8	5.3	1.1	2.3	-2.0	-0.6
Impedance of whole body	3.7	18.7	39.7	5.0	3.2	0.2	6.3
Leg fat mass (left)	0.5	2.0	5.3	-0.5	0.7	-2.3	-1.3
Arm predicted mass (left)	1.5	7.7	18.3	-3.0	-1.6	0.9	-4.3