TWAS hub - METTL16

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.192	0.0566	7.1e-05	0.062	NA	0.074	NA	0.041	1.0e-06	NA	1.0e-07	NA	6.6e-05
2	METSIM	Adipose	0.192	0.0373	2.4e-11	0.101	0.091	0.123	0.117	0.136	6.5e-15	1.9e-13	5.4e-18	3.9e-17	8.8e-20

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Alcohol usually taken with meals	7.9	12.7	22.5	-4.7	-1.7
Hearing difficulty/problems with background noise	6.7	10.7	18.4	1.7	4.3
Hearing difficulty/problems: Yes	6.6	10.1	14.9	2.3	3.9
Frequency of tiredness / lethargy in last 2 weeks	6.0	9.8	14.0	2.4	3.7
Happiness	5.8	7.1	9.5	2.1	3.1
Impedance of leg (right)	5.2	25.1	43.6	6.6	2.6
Impedance of leg (left)	5.2	25.4	42.1	6.5	3.0
Noisy workplace	5.1	6.2	8.4	2.9	2.0
Medication for hormone replacement therapy	5.0	5.6	7.7	2.8	1.8
Ever highly irritable/argumentative for 2 days	4.9	5.8	11.6	-0.1	3.4
Number of full sisters	4.7	5.8	8.4	1.8	2.9
Average weekly fortified wine intake	4.4	5.1	9.6	-3.1	-0.8
Systolic blood pressure, automated reading	4.2	12.1	18.9	4.4	-2.3
Fractured/broken bones in last 5 years	4.2	5.4	5.9	-2.2	-2.4
Systolic Blood Pressure	3.8	19.0	36.2	6.0	-1.3
Mother’s age at death	3.7	4.6	8.1	-1.1	-2.8
Neuroticism (Nagel 2018)	3.6	8.6	10.0	3.2	2.7
Alzheimer’s Disease (in father)	3.6	3.9	4.7	-2.2	-1.8
Qualifications: College or University degree	3.5	11.1	11.6	-3.3	-3.4
Miserableness	3.5	6.0	8.2	2.0	2.9
Overall health rating	3.4	7.2	9.2	2.3	3.0
Pack years of smoking	3.4	5.0	9.9	3.1	0.5
Mood swings	3.3	5.9	7.9	2.8	2.0
Age at first live birth	3.2	5.7	7.5	-2.0	-2.7
Hearing aid user	3.2	3.7	5.4	2.3	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.1	3.7	6.1	2.5	1.1
Depressed Affect (Nagel 2018)	3.0	6.3	6.7	2.6	2.4
Worry too long after embarrassment	3.0	5.0	6.8	1.8	2.6
Age at last live birth	3.0	4.4	4.9	-2.2	-1.9
Neuroticism (2016)	2.9	4.2	4.3	2.1	2.0
Qualifications: None of the above	2.9	6.2	11.3	3.4	1.0
Impedance of whole body	2.9	14.6	27.1	5.2	1.5
Nervous feelings	2.8	5.3	9.2	3.0	1.2
Birth weight	2.8	6.0	7.4	2.1	-2.7
Neuroticism	2.7	6.6	7.8	2.3	2.8
Pack years adult smoking proportion	2.7	4.2	8.2	2.9	0.3
Knee pain experienced in last month	2.7	4.3	8.5	-2.9	-0.2
Illnesses of father: High blood pressure	2.7	3.4	3.4	1.8	1.8
Reaction Time	2.6	4.9	9.5	-0.5	-3.1
Supplements: Glucosamine	2.6	3.3	5.4	-2.3	-1.1
Medication: Lansoprazole	2.6	3.0	5.1	-2.3	-0.9
Shortness of breath walking on level ground	2.6	3.1	6.2	-0.0	2.5
Had other major operations	2.5	3.0	6.0	0.2	2.4
Migraine (self-reported)	2.5	3.1	3.3	1.7	1.8
Mean time to correctly identify matches	2.5	4.8	9.2	-0.6	-3.0
Financial difficulties in last 2 years	2.4	3.2	3.4	1.7	1.9
Mouth/teeth dental problems: Bleeding gums	2.4	3.1	5.4	-2.3	-0.9
Leg fat percentage (right)	2.4	8.6	15.3	3.9	1.4
Number of full brothers	2.3	2.9	5.3	2.3	0.7
Friendships satisfaction	2.3	2.8	4.3	1.1	2.1
Qualifications: nursing, teaching	2.3	3.6	7.1	-2.7	-0.1
Leg predicted mass (right)	2.3	12.1	15.1	-3.9	-3.0
Commuting to job workplace: Cycle	2.3	2.8	5.5	-2.4	0.1
Blood Platelet Count	2.2	25.6	50.0	7.1	-1.1
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.7	3.1	1.8	1.5
Leg fat-free mass (right)	2.2	11.9	15.0	-3.9	-3.0
Schizophrenia vs Biploar Disorder	2.1	2.7	4.7	2.2	0.9
Lung cancer (father)	2.1	2.5	4.8	-0.4	-2.2
Medication: Omeprazole (e.g. Zanprol)	2.1	2.5	5.0	0.2	2.2
LDL Cholesterol	2.0	3.2	6.3	2.5	-0.0
Leg fat-free mass (left)	2.0	10.4	11.3	-3.4	-3.1
Neuroticism score	2.0	4.2	5.7	1.7	2.4
Medication: Seretide 50 evohaler	2.0	2.3	4.0	2.0	0.9
Wears glasses or contact lenses	2.0	2.3	2.4	1.5	1.6
Commuting to job workplace: Public transport	2.0	2.4	4.8	-2.2	-0.3
Leg fat percentage (left)	2.0	7.3	12.5	3.5	1.4
Alcohol drinker status: Previous	2.0	2.3	3.1	1.2	1.8
Sensitivity / hurt feelings	1.9	3.3	3.8	1.7	2.0
Severe depression (siblings)	1.9	2.1	3.5	-0.8	1.9
Leg predicted mass (left)	1.9	10.1	10.9	-3.3	-3.0
Whole body water mass	1.9	10.8	13.4	-3.7	-2.9
Ever used hormone-replacement therapy (HRT)	1.8	2.3	4.5	2.1	0.4
Number of incorrect matches in round	1.8	3.0	6.0	0.1	2.5
Medication: Cholesterol lowering	1.8	2.7	3.2	1.5	1.8
Commuting to job workplace: Car/motor vehicle	1.8	2.1	3.8	2.0	-0.6
Whole body fat-free mass	1.8	10.4	13.2	-3.6	-2.8
Average weekly champagne plus white wine intake	1.8	2.5	4.9	-2.2	-0.2
Irritability	1.8	3.0	5.2	0.9	2.3
Diastolic blood pressure, automated reading	1.8	5.7	9.0	3.0	-1.5
Smoking Status	1.7	4.0	7.6	-0.6	2.8
Relative age of first facial hair	1.7	3.6	6.7	2.6	0.7
Trunk fat-free mass	1.7	10.0	13.9	-3.7	-2.5
Trunk predicted mass	1.7	9.8	13.5	-3.7	-2.5
Length of working week for main job	1.7	1.9	3.8	1.9	-0.2
Average weekly red wine intake	1.7	2.6	2.9	-1.7	-1.5
Illnesses of father: None of the above (group 1)	1.7	2.1	4.2	2.1	0.1
Ulcerative Colitis	1.6	2.3	4.2	-0.7	2.0
Ever had hysterectomy (womb removed)	1.6	1.8	2.0	1.3	1.4
Forced vital capacity (FVC)	1.6	6.2	11.9	-0.6	-3.5
Father’s age at death	1.6	2.2	4.1	-2.0	0.5
Loud music exposure frequency	1.6	1.7	2.7	1.6	-0.8
Guilty feelings	1.6	2.5	4.4	0.7	2.1
Primary Biliary Cirrhosis	1.5	2.2	4.3	0.3	2.1
Fed-up feelings	1.5	2.7	5.0	0.7	2.2
Hair/balding pattern: Pattern 2	1.5	1.8	2.1	1.2	1.5
Alcohol intake versus 10 years previously	1.5	2.2	4.4	0.2	-2.1
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	2.4	-1.6	1.0
Neck or shoulder pain in last month	1.5	2.1	3.1	1.1	1.8
Family relationship satisfaction	1.5	1.8	2.3	1.2	1.5
Supplements: Calcium	1.5	1.7	1.8	-1.3	-1.2
Irritable Bowel Disease (IBD)	1.4	3.3	6.6	-0.2	2.6
Current tobacco smoking	1.4	2.3	4.3	-0.5	2.1
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	4.8	-2.2	1.2
Allergy	1.4	3.2	6.4	2.5	0.2
Comparative body size at age 10	1.4	3.8	5.9	-1.3	-2.4
Health satisfaction	1.4	1.8	3.5	-0.3	1.9
Osteoarthritis (self-reported)	1.4	1.8	2.4	-1.1	1.5
Medication: Gliclazide	1.4	1.6	1.7	-1.3	-1.2
Smoking status: Current	1.4	2.3	4.0	-0.7	2.0
Basal metabolic rate	1.4	7.7	8.6	-2.9	-2.6
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.6	-1.9	-0.2
Multivitamins +/- minerals	1.3	1.6	1.8	-1.2	-1.3
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	3.8	0.3	2.0
Had menopause	1.3	1.6	2.3	1.5	0.9
Blood clot in the leg (DVT)	1.3	1.6	3.3	-1.8	-0.0
Body fat percentage	1.3	5.0	10.0	3.2	-0.2
Illnesses of father: Heart disease	1.3	1.8	3.5	-1.9	0.4
Number of self-reported non-cancer illnesses	1.3	2.2	4.3	0.3	2.1
Alcohol drinker status: Never	1.3	1.5	2.0	-1.0	-1.4
Fasting Glucose	1.2	1.4	2.5	1.6	0.6
Schizophrenia (2014)	1.2	2.7	3.1	1.8	1.5
Hair/balding pattern: Pattern 4	1.2	2.9	3.3	1.8	-1.6
Glaucoma (self-reported)	1.2	1.4	1.9	1.4	0.9
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.5	0.6	1.6
Comparative height size at age 10	1.2	6.6	10.0	-1.8	-3.2
Number of operations (self-reported)	1.2	1.7	2.0	1.4	1.2
Pain experienced in last month	1.2	2.1	4.0	0.4	-2.0
Alzheimer’s Disease (including proxy)	1.1	1.6	3.0	-1.7	-0.5
Crohns Disease (2012)	1.1	1.8	3.2	0.7	1.8
Mean Putamen Volume	1.1	1.3	1.6	-1.3	-1.0
Rheumatoid Arthritis	1.1	1.5	2.9	0.3	-1.7
Allergy or Eczema	1.1	3.0	5.8	-2.4	0.4
Number of treatments/medications taken	1.1	2.0	2.9	1.1	1.7
Trunk fat percentage	1.1	4.6	9.0	3.0	-0.4
Medication: Simvastatin	1.1	1.7	1.9	1.2	1.4
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	7.0	0.5	-2.6
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	2.7	-1.0	-1.6
Arm fat-free mass (right)	1.1	5.5	7.1	-2.7	-2.0
Wheeze or whistling in the chest in last year	1.1	2.0	3.9	-2.0	-0.2
Arm predicted mass (right)	1.1	5.4	6.2	-2.5	-2.1
Arm predicted mass (left)	1.1	5.7	6.3	-2.5	-2.3
Body Mass Index (BMI) (2010)	1.0	1.3	1.8	-1.3	-0.9
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.2	-0.3	-1.5
Average weekly spirits intake	1.0	1.3	2.0	-1.4	-0.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.2	-1.5	0.4
Hayfever, allergic rhinitis or eczema	1.0	2.2	4.3	-2.1	0.2
Medication: Atenolol	1.0	1.2	2.5	0.1	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	5.6	0.7	-2.4
Medication: Omeprazole	1.0	1.2	2.4	0.0	1.5
Heart disease (mother)	1.0	1.2	1.6	1.3	-0.9
Medication for cholesterol	1.0	1.4	2.6	-0.5	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.4	0.2	1.6
Arm fat-free mass (left)	1.0	5.0	5.1	-2.2	-2.2
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.2	-1.5	-0.3
Ever depressed for a whole week	1.0	1.2	2.5	0.2	1.6
Heart disease (siblings)	1.0	1.2	1.7	-0.9	1.3
Worry (Nagel 2018)	0.9	2.0	3.5	1.9	0.7
Ulcerative Colitis (UC)	0.9	1.7	3.0	-0.5	1.7
Qualifications: CSEs or equivalent	0.9	1.2	1.6	1.3	0.8
Mouth/teeth dental problems	0.9	1.4	1.5	1.2	-1.2
Diabetes (self-reported)	0.9	1.4	2.6	-1.6	-0.4
Impedance of arm (right)	0.9	4.0	8.0	2.8	-0.3
Impedance of arm (left)	0.9	4.4	8.8	3.0	-0.1
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.7	-1.7	0.2
Emphysema/chronic bronchitis	0.9	1.0	1.8	1.3	0.5
Pulse rate, automated reading	0.9	2.8	4.8	2.2	0.9
Alcohol intake frequency.	0.9	2.1	2.7	1.6	1.2
Financial situation satisfaction	0.9	1.1	1.7	-0.8	1.3
Eye problems/disorders: Glaucoma	0.9	1.0	1.0	1.0	1.0
Alzheimer’s Disease (in mother)	0.8	1.0	1.6	-1.3	0.6
Crohns Disease (2017)	0.8	1.8	3.6	-0.3	1.9
Cardiovascular Disease	0.8	2.5	3.1	1.4	1.8
Type 2 Diabetes (T2D) (2018)	0.8	1.4	2.0	-1.4	-0.9
Angina	0.8	1.1	1.4	1.2	0.8
Medication: Co-codamol	0.8	0.9	0.9	-0.9	1.0
Past tobacco smoking	0.8	1.4	2.7	0.3	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.7	-0.8	1.3
Birth weight of first child	0.8	1.5	2.7	1.6	0.6
Forced vital capacity (FVC), Best measure	0.8	2.9	5.8	0.4	-2.4
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.2	0.8	1.1
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.0	1.0	1.0
High cholesterol (Self-reported)	0.8	1.4	2.2	0.8	1.5
Bipolar Disorder (2018)	0.7	1.1	1.6	-1.3	-0.8
Heel T-Score	0.7	5.9	10.8	-3.3	1.0
Lung FEV1/FVC ratio	0.7	3.7	7.1	2.7	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.7	0.0	1.3
Had major operations	0.7	0.8	1.1	1.1	-0.7
Illnesses of siblings: Diabetes	0.7	0.8	1.5	-1.2	-0.5
Asthma (self-reported)	0.7	1.4	2.8	-1.7	-0.4
Medication: Lisinopril	0.7	0.9	1.7	-0.5	1.3
Ever smoked	0.7	1.2	1.4	-1.0	1.2
Myopia	0.7	1.0	1.6	-1.3	-0.6
Basal cell carcinoma (self-reported)	0.7	0.8	1.6	-0.2	-1.3
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.9	-0.3	-1.7
Breast Cancer	0.6	1.4	2.4	1.5	0.6
Age when periods started (menarche)	0.6	1.4	2.0	0.9	1.4
Stomach or abdominal pain in last month	0.6	0.8	1.4	-0.3	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.0	-0.9	1.4
Illnesses of siblings	0.6	0.9	1.7	1.3	-0.0
Asthma	0.6	1.2	2.3	-1.5	-0.2
Pulse wave Arterial Stiffness index	0.6	0.7	1.3	1.2	0.2
Exposure to tobacco smoke at home	0.6	0.7	0.7	0.8	0.8
Angina (self-reported)	0.6	0.8	1.0	1.0	0.7
Smoking status: Previous	0.6	0.8	1.7	-0.0	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.7	1.6	-0.0
Supplements: Fish oil (including cod liver oil)	0.6	0.7	0.9	1.0	0.7
Medication: Atorvastatin	0.6	0.7	1.1	1.1	0.6
HDL Cholesterol	0.5	0.9	1.7	1.3	0.3
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.2	-0.5	1.1
Supplements: Zinc	0.5	0.6	1.2	-1.1	0.0
Medication: Metformin	0.5	0.7	1.1	-1.1	-0.5
Diabetes (father)	0.5	0.6	1.2	1.1	0.1
Taking other prescription medications	0.5	0.7	1.2	0.5	1.1
Chronic bronchitis/emphysema (father)	0.5	0.6	1.2	-1.1	0.0
Heart attack	0.5	0.7	1.2	-1.1	0.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.3	-0.3	1.2
Depression (self-reported)	0.5	0.6	1.1	-0.1	1.1
Standing height	0.5	5.1	7.8	-1.6	-2.8
Pulse wave reflection index	0.5	0.7	1.3	1.1	0.2
Medication: Paracetamol	0.5	0.8	0.9	0.9	0.9
High blood pressure (siblings)	0.5	0.7	0.8	-0.9	-0.8
Pulse wave peak to peak time	0.5	0.6	1.2	-1.1	-0.2
Medication for pain relief, constipation, heartburn	0.5	0.9	1.1	-0.8	-1.1
Leg fat mass (right)	0.5	2.1	4.1	2.0	0.2
Medication: Aspirin	0.5	0.6	0.9	-0.6	-0.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.7	0.8	-0.7
Medication: Blood pressure	0.5	1.0	1.0	-1.0	1.0
Major Depression (MDD)	0.4	0.5	0.8	0.5	0.9
Ovarian Cancer	0.4	0.6	0.9	-0.9	0.5
Triglycerides	0.4	0.6	1.2	1.1	0.1
Blood Eosinophil Count	0.4	3.2	4.9	-1.2	-2.2
Blood White Count	0.4	2.7	4.2	2.0	-1.1
Respiratory disease	0.4	0.8	1.3	-1.1	-0.6
Chronotype (morning person)	0.4	0.9	1.7	1.3	0.4
Maternal smoking around birth	0.4	0.5	1.0	-1.0	-0.2
Sitting height	0.4	2.7	4.2	1.1	-2.1
Trunk fat mass	0.4	1.9	2.8	1.7	-1.0
Pain all over the body in last month	0.4	0.5	0.7	0.8	-0.5
Medication: Ramipril	0.4	0.6	0.9	-0.9	0.5
Falls in the last year	0.4	0.6	1.0	-1.0	-0.4
Number of live births	0.4	0.6	1.2	-0.2	1.1
Prospective memory result	0.4	0.4	0.6	0.7	-0.6
Breastfed as a baby	0.4	0.5	0.7	-0.5	-0.8
Peak expiratory flow (PEF)	0.4	1.0	1.1	0.9	-1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.6	-0.2	-1.3
Medication: Amlodipine	0.4	0.6	1.0	-1.0	0.4
Eye problems/disorders: None of the above	0.4	0.4	0.8	0.9	0.1
Whole body fat mass	0.4	1.7	2.8	1.7	-0.8
Supplements: Vitamin C	0.4	0.5	1.0	-1.0	0.1
Diabetes diagnosed by doctor	0.4	0.6	1.2	-1.1	-0.2
Commuting to job workplace: Walk	0.4	0.4	0.8	0.9	-0.1
Breast cancer (self-reported)	0.4	0.4	0.8	0.9	0.2
Average weekly beer plus cider intake	0.4	0.5	1.0	1.0	0.3
Risk taking	0.4	0.6	1.1	-0.2	1.0
Leg fat mass (left)	0.4	1.8	3.5	1.9	0.2
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.8	0.1	-1.4
Prostate Cancer	0.3	0.5	0.5	-0.7	-0.6
Coronary Artery Disease (CAD)	0.3	0.3	0.6	0.0	-0.8
Lupus	0.3	0.5	0.9	0.9	0.4
Waist Hip Ratio (WHR)	0.3	1.4	2.7	-0.4	-1.6
Hypothyroidism (self reported)	0.3	0.8	1.0	-1.0	-0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.5	0.7	-0.3
Weight	0.3	1.6	2.6	-0.8	-1.6
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.3	-1.2	0.2
Illnesses of mother	0.3	0.3	0.3	0.6	0.6
Exposure to tobacco smoke outside home	0.3	0.4	0.8	0.9	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.5	-0.5	-0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.6	-0.7	-0.2
Leg pain on walking	0.3	0.3	0.5	0.7	0.4
Arm fat percentage (left)	0.3	1.0	1.5	1.2	-0.8
Loneliness, isolation	0.3	0.4	0.5	0.6	0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.8	0.1	0.9
Medication: Bendroflumethiazide	0.3	0.4	0.8	-0.9	-0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	-0.9	0.3
Depression (Nagel 2018)	0.2	0.4	0.7	0.2	0.8
BMI	0.2	1.3	2.3	-0.5	-1.5
Height	0.2	4.7	9.3	-0.1	-3.0
Lung FVC	0.2	1.3	1.4	1.1	-1.2
Hand grip strength (right)	0.2	0.6	0.9	1.0	-0.6
Townsend deprivation index at recruitment	0.2	0.3	0.5	-0.7	0.2
Serious illness, injury or assault to yourself	0.2	0.3	0.4	0.3	-0.7
Medication: Levothyroxine sodium	0.2	0.4	0.7	-0.1	-0.9
High blood pressure (mother)	0.2	0.2	0.2	0.5	-0.5
Arm fat percentage (right)	0.2	1.0	1.3	1.1	-0.8
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	0.8	0.2
Arm fat mass (right)	0.2	0.7	1.4	0.2	-1.2
Tense / ‘highly strung’	0.2	0.4	0.7	0.2	0.9
Headache pain in last month	0.2	0.4	0.8	0.1	-0.9
Gout (self-reported)	0.2	0.3	0.5	0.2	-0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	0.3	0.6
Number of children fathered	0.2	0.3	0.5	-0.7	-0.2
Hypertension (Self-reported)	0.2	0.6	0.8	0.7	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.6	0.5	-0.8
Arm fat mass (left)	0.2	0.7	1.3	0.2	-1.1
Cholesterol lowering medication	0.2	0.3	0.6	0.2	0.8
Schizophrenia (2018)	0.1	0.2	0.2	0.5	0.4
Age at First Birth	0.1	0.2	0.2	-0.3	-0.5
Hair Pigment	0.1	1.9	2.1	-1.4	-1.3
Hand grip strength (left)	0.1	0.2	0.3	0.4	-0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.2	0.4	-0.4
Vitamin and mineral supplements	0.1	0.1	0.1	0.4	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.4	0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.2	-0.3	-0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.2	-0.5	-0.3
High blood pressure	0.1	0.3	0.4	0.5	0.6
Waist circumference	0.1	0.2	0.4	-0.3	-0.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.3	0.4
Fluid intelligence score	0.1	0.1	0.2	-0.2	-0.4
Worrier / anxious feelings	0.1	0.1	0.1	-0.4	0.3
Pulse rate	0.1	0.1	0.2	0.4	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.3	0.2	-0.5
Medication: Allopurinol	0.1	0.1	0.2	-0.4	0.2
Suffer from ‘nerves’	0.1	0.2	0.3	0.6	-0.2
Chest pain or discomfort	0.1	0.2	0.3	0.2	-0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.1	-0.4
Long-standing illness, disability or infirmity	0.1	0.1	0.3	0.2	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.3	0.5
Eye problems/disorders: Cataract	0.1	0.2	0.2	-0.5	-0.3
Back pain experienced in last month	0.1	0.2	0.2	0.5	0.4
Osteoporosis (self-reported)	0.1	0.2	0.3	0.6	0.1
Medication: Aspirin	0.1	0.1	0.2	-0.4	-0.2
Medication: Paracetamol	0.1	0.1	0.2	0.2	0.4
Age started oral contraceptive pill	0.1	0.1	0.2	0.2	-0.5
Unable to work because of sickness or disability	0.1	0.2	0.2	0.4	-0.4
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.6	-0.4	-0.8
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	-0.4	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
HbA1C	0.0	0.0	0.0	-0.0	-0.1
Blood Red Count	0.0	0.3	0.5	-0.7	0.3
Tanning	0.0	0.4	0.7	0.8	-0.3
Diabetes (mother)	0.0	0.0	0.1	0.0	-0.3
Relative age voice broke	0.0	0.0	0.0	0.1	0.0
Body mass index (BMI)	0.0	0.0	0.1	-0.1	-0.3
Hip circumference	0.0	0.1	0.1	-0.2	-0.3
Time employed in main current job	0.0	0.0	0.1	-0.1	0.2
Hair/balding pattern: Pattern 3	0.0	0.1	0.1	0.3	-0.2
Medication: Blood pressure	0.0	0.0	0.0	0.2	0.1
Medication: Ibuprofen	0.0	0.0	0.0	-0.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.1	0.1	0.1	-0.3
Ever had bowel cancer screening	0.0	0.0	0.1	-0.2	0.1
Mineral and other dietary supplements	0.0	0.0	0.0	0.2	0.1
Ever taken oral contraceptive pill	0.0	0.1	0.1	0.3	-0.1

Hub : Genes

METTL16

Models

Trait associations