TWAS hub - KANK2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1630	0.0600	4.9e-03	0.050	NA	0.035	NA	0.027	5.2e-04	NA	3.2e-03	NA	8.7e-03
2	GTEx	Heart Left Ventricle	0.2367	0.0788	1.5e-03	0.040	NA	0.086	NA	0.109	3.4e-03	NA	2.4e-05	NA	2.1e-06
3	NTR	Blood	0.0998	0.0226	9.7e-12	0.038	0.042	0.044	0.048	0.041	2.7e-12	2.0e-13	4.1e-14	2.7e-15	2.7e-13
4	YFS	Blood	0.0543	0.0173	8.0e-05	0.022	0.008	0.022	0.025	0.018	5.5e-08	1.2e-03	8.4e-08	8.6e-09	7.8e-07
5	TCGA	Brain Lower Grade Glioma	0.2839	0.0561	0.0e+00	0.257	0.205	0.249	NA	0.257	4.5e-29	6.8e-23	5.3e-28	NA	4.6e-29
6	TCGA	Prostate Adenocarcinoma	0.0939	0.0365	2.8e-05	0.040	0.058	0.057	NA	0.050	4.3e-05	9.5e-07	1.3e-06	NA	5.7e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
LDL Cholesterol	16.6	26.3	72.1	1.3	3.3	-3.2	0.4	8.5	7.9
High cholesterol (Self-reported)	11.8	21.0	59.6	-1.1	2.2	-3.2	-0.1	7.7	7.1
Medication: Atorvastatin	8.4	10.4	35.3	0.6	2.6	-1.1	0.5	5.9	4.3
Cholesterol lowering medication	8.2	12.1	31.2	-2.2	0.4	-2.9	-1.2	5.6	5.2
Medication: Cholesterol lowering	6.5	10.1	24.1	-0.2	2.3	-3.8	-1.5	4.9	3.7
High blood pressure (mother)	6.0	8.4	21.9	-4.7	-3.7	-2.6	-2.7	0.8	-0.1
Systolic Blood Pressure	5.6	28.0	77.1	-6.4	-2.4	-6.0	-8.8	-1.4	-2.4
Medication: Simvastatin	4.4	6.5	12.5	-1.8	1.0	-3.5	-2.1	2.7	3.3
Illnesses of mother	4.1	5.0	14.1	3.8	2.7	1.9	2.1	-0.4	0.9
HDL Cholesterol	4.0	6.7	11.6	3.4	2.2	2.4	3.0	-2.1	-2.1
Myopia	3.4	5.0	20.3	-0.1	0.7	1.5	0.2	-4.5	-2.6
Heart attack/myocardial infarction (self-reported)	3.4	4.4	10.0	0.4	2.2	-1.7	-1.2	2.6	3.2
Angina	3.3	4.3	9.5	1.6	2.3	-0.7	0.6	2.8	3.1
Angina (self-reported)	3.2	4.2	9.2	1.7	2.2	-0.5	0.9	2.6	3.0
Eye problems/disorders: Glaucoma	3.2	3.8	10.0	-3.2	-3.0	0.2	0.3	-1.1	-1.5
Heart attack	3.1	4.0	8.8	0.3	2.2	-1.7	-1.1	2.5	3.0
Coronary Artery Disease (CAD)	2.9	3.4	11.9	-1.0	0.9	-3.5	-2.6	0.0	0.0
Cardiovascular Disease	2.9	9.5	20.0	-4.5	-0.7	-3.7	-4.1	1.7	1.6
Diastolic blood pressure, automated reading	2.9	9.1	13.3	-3.6	-3.3	-0.3	-2.9	-3.3	-3.3
Lung cancer (father)	2.8	3.3	8.5	-0.5	-0.4	-2.0	-2.1	-1.5	-2.9
Rheumatoid Arthritis	2.6	3.6	13.2	-0.8	-1.8	-0.4	-0.5	-3.6	-2.0
Number of live births	2.6	3.7	10.1	1.2	0.3	-1.0	0.4	3.2	3.1
Asthma	2.6	5.2	9.1	3.0	1.8	2.5	2.3	-2.0	2.0
High blood pressure (siblings)	2.6	3.7	8.9	-2.5	-1.3	-2.2	-3.0	-0.5	0.2
Comparative height size at age 10	2.6	14.0	49.2	1.2	-0.4	-0.9	-1.2	-7.0	-5.6
Asthma (self-reported)	2.5	5.0	8.4	2.9	1.7	2.4	2.3	-2.0	1.9
Supplements: Glucosamine	2.4	3.1	5.7	1.7	2.3	-0.2	-0.2	-2.4	-2.2
Number of full brothers	2.4	3.0	8.0	-2.8	-2.5	-1.1	-1.4	0.0	-0.8
Medication: Seretide 50 evohaler	2.4	2.8	8.1	1.6	1.9	1.3	0.7	-2.9	-0.4
Respiratory disease	2.3	5.2	7.3	2.7	1.4	2.4	2.5	-2.5	1.8
Medication: Atenolol	2.3	2.8	12.0	-3.5	-1.9	0.0	-1.1	-0.2	0.2
Systolic blood pressure, automated reading	2.2	6.5	18.9	-2.8	-0.7	-2.9	-4.3	-1.2	-1.3
Pulse rate	2.2	3.8	10.6	1.4	1.8	-0.5	-1.1	-3.2	-2.3
Medication for cholesterol, blood pressure or diabetes	2.2	3.7	8.5	1.0	-0.6	2.9	1.6	-2.8	-1.4
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.2	10.3	-2.3	-3.2	-1.0	-1.1	0.0	-1.1
Shortness of breath walking on level ground	2.1	2.5	7.3	2.7	2.4	0.8	1.1	-0.9	0.2
Heart disease (mother)	2.1	2.6	4.5	-2.1	-0.4	-1.8	-1.7	2.1	0.2
Leg pain on walking	2.1	2.7	3.9	1.2	1.9	-0.7	-1.9	-2.0	-1.6
Illnesses of father: Heart disease	2.1	3.0	6.3	-2.1	0.3	-1.3	-0.7	2.5	2.2
Neuroticism (2016)	2.0	2.8	6.2	-2.2	-1.6	0.2	-0.3	-1.7	-2.5
Fluid intelligence score	2.0	4.1	7.7	2.2	1.9	1.6	2.1	1.3	2.8
Standing height	2.0	19.9	71.2	3.0	1.1	0.1	-0.2	-8.4	-6.2
Medication: Ibuprofen	2.0	2.4	4.5	-2.1	-2.1	-0.2	-1.1	-0.6	-1.9
Average weekly beer plus cider intake	2.0	2.9	5.7	-1.7	-1.9	0.1	-1.5	-2.4	-1.8
Frequency of depressed mood in last 2 weeks	1.9	2.7	5.2	-1.3	-2.3	-1.9	-1.6	-1.0	-1.6
Glaucoma (self-reported)	1.9	2.3	3.6	-1.8	-1.8	0.5	0.3	-1.9	-1.7
Pain type(s) experienced in last month: Hip pain	1.9	2.4	7.5	1.5	0.3	-2.7	-2.0	0.7	-0.5
Height	1.8	35.5	123.2	4.8	2.1	1.8	1.6	-11.1	-7.5
Lung FEV1/FVC ratio	1.8	9.0	14.7	-3.4	-3.8	-2.7	-3.1	3.2	-0.5
Medication: Amlodipine	1.8	2.6	5.1	-1.9	-0.4	-0.4	-1.7	-2.3	-1.9
Illnesses of father: High blood pressure	1.8	2.2	4.8	-2.2	-1.6	-1.3	-2.0	-0.3	-0.1
Medication: Ventolin 100micrograms inhaler	1.7	2.1	9.1	1.4	0.3	0.9	0.8	-3.0	-0.4
Had other major operations	1.6	1.9	4.9	0.1	-0.0	-2.2	-2.2	1.2	-0.4
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	4.3	-2.1	-2.0	0.8	-0.3	-0.5	-1.8
Pulse rate, automated reading	1.6	5.1	21.2	1.0	-0.1	-0.3	-1.1	-4.6	-2.7
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	6.7	-2.2	-2.6	0.3	0.1	-0.0	0.2
Medication: Blood pressure	1.6	3.1	6.7	-2.2	-1.1	-1.6	-2.6	-1.3	-1.2
Risk taking	1.6	2.3	4.1	-0.1	0.8	-1.9	-2.0	-1.7	-1.7
Ever had prostate specific antigen (PSA) test	1.6	1.9	6.4	-0.1	-0.9	-2.5	-1.3	-0.7	-1.3
Alzheimer’s Disease (in mother)	1.5	1.7	6.5	-0.0	-0.2	1.1	2.5	1.5	0.7
Allergy	1.5	3.4	8.5	-2.3	-1.4	-0.4	-1.6	-1.4	-2.9
Father’s age at death	1.5	2.0	3.7	1.4	0.4	1.9	1.6	-1.3	-1.4
Birth weight	1.5	3.2	8.2	0.1	-0.8	-1.2	-1.8	-2.4	-2.9
Leg fat percentage (right)	1.5	5.4	18.1	-1.3	-2.4	0.3	1.3	4.3	2.3
Suffer from ‘nerves’	1.5	2.4	6.3	-2.0	-2.5	-0.7	-0.7	1.3	1.0
Hypertension (Self-reported)	1.5	4.2	8.5	-2.9	-1.2	-1.0	-2.5	-2.2	-1.7
Guilty feelings	1.5	2.3	6.7	-2.0	-0.6	-1.4	-2.6	0.8	-0.2
Alcohol drinker status: Never	1.5	1.8	4.7	0.3	-0.4	1.2	2.2	-1.3	-1.8
Leg fat percentage (left)	1.5	5.4	20.0	-0.9	-2.1	0.2	1.3	4.5	2.4
Vascular/heart problems diagnosed by doctor	1.5	4.2	10.7	3.3	1.3	1.7	2.8	1.0	0.9
Ever had hysterectomy (womb removed)	1.4	1.6	4.3	-1.2	-2.1	-1.3	-1.0	0.4	-0.8
Average weekly fortified wine intake	1.4	1.7	3.2	-1.8	-0.9	-1.5	-1.8	0.8	-0.3
High blood pressure	1.4	4.0	10.2	-3.2	-1.3	-1.2	-2.6	-1.5	-1.3
Nervous feelings	1.4	2.5	4.9	-2.2	-2.2	-1.4	-1.3	0.6	1.1
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	5.3	1.4	0.8	1.8	2.3	0.1	0.6
Pulse wave Arterial Stiffness index	1.4	1.7	5.2	-1.0	-1.0	0.3	-0.8	-2.3	-1.5
Hair/balding pattern: Pattern 4	1.4	3.4	7.6	2.7	2.8	0.9	1.1	0.6	1.8
Birth weight of first child	1.4	2.5	6.3	2.5	0.7	0.4	0.5	-2.4	-1.4
Pulse wave reflection index	1.4	1.7	2.8	-1.1	-1.2	1.6	1.2	1.7	0.9
Illnesses of father: None of the above (group 1)	1.4	1.7	5.4	2.3	-0.8	0.7	1.2	-1.0	-1.0
Age started oral contraceptive pill	1.4	1.8	4.1	-1.0	-1.1	0.3	0.5	-2.0	-2.0
Ovarian Cancer	1.3	1.7	3.5	-1.5	-1.9	-1.2	-1.5	0.7	-0.0
Medication: Ramipril	1.3	1.7	4.9	-0.7	0.9	-1.7	-2.2	-0.9	-0.7
Length of working week for main job	1.3	1.5	4.8	1.9	2.2	-0.4	-0.4	-0.4	-0.3
Peak expiratory flow (PEF)	1.3	3.1	7.3	-1.1	-2.0	-2.0	-2.7	-0.1	-1.4
Pulse wave peak to peak time	1.3	1.5	3.9	1.4	1.2	-0.5	0.7	2.0	1.1
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.8	1.7	1.9	0.8	1.2	0.4	0.4
Depression (Nagel 2018)	1.2	1.8	3.4	-1.2	-1.8	-1.3	-1.0	-0.4	-1.8
Triglycerides	1.2	1.9	4.2	-0.4	0.2	-2.0	-1.5	2.0	1.0
Qualifications: CSEs or equivalent	1.2	1.6	4.9	-1.1	-0.7	2.2	0.7	-1.6	0.0
Impedance of arm (right)	1.2	5.6	22.8	-0.5	-0.2	0.6	-1.4	-4.8	-2.8
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	4.5	-0.8	-2.1	0.5	0.1	-1.5	-0.6
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	5.5	0.4	-0.1	0.6	1.2	1.9	2.4
Wheeze or whistling in the chest in last year	1.2	2.1	4.0	2.0	0.8	1.6	1.8	-1.2	0.9
Medication for cholesterol	1.2	1.8	3.4	-0.0	-1.1	1.8	1.4	-0.9	-1.8
Body Mass Index (BMI) (2010)	1.1	1.6	2.7	-1.4	-1.5	0.0	-0.3	1.5	1.7
Crohns Disease (2012)	1.1	1.7	2.8	-0.8	-1.2	-1.3	-1.0	1.7	1.6
Type 2 Diabetes (T2D) (2012)	1.1	1.3	4.1	-1.3	-0.7	-0.7	-2.0	0.0	-1.0
Waist Hip Ratio (WHR)	1.1	4.7	22.6	-1.8	-0.3	0.1	-1.5	-4.8	-0.6
Average weekly spirits intake	1.1	1.3	3.3	-0.9	-1.8	-0.8	-0.3	1.7	-0.3
Vitamin and mineral supplements	1.1	1.4	4.3	1.1	0.7	0.2	1.4	0.9	2.1
Hayfever, allergic rhinitis or eczema	1.1	2.3	5.2	1.5	0.8	0.1	1.3	2.0	2.3
Had menopause	1.1	1.3	3.8	0.8	-0.1	1.9	1.9	0.4	0.3
Illnesses of siblings	1.1	1.6	4.9	2.2	1.5	0.6	1.3	0.3	-0.6
Mouth/teeth dental problems: Dentures	1.1	1.9	6.0	-1.9	-2.5	0.1	0.7	1.2	-0.2
Impedance of arm (left)	1.1	5.3	19.3	-0.2	-0.3	-0.3	-1.9	-4.4	-3.0
Mouth/teeth dental problems: Loose teeth	1.1	1.2	3.2	-1.8	-1.6	0.5	0.5	-0.3	-1.1
Knee pain experienced in last month	1.1	1.7	4.0	1.3	0.8	0.3	-0.6	-2.0	-1.8
Eye problems/disorders: Cataract	1.1	1.3	2.8	0.8	1.6	-1.7	-0.0	0.8	1.2
Osteoporosis (self-reported)	1.1	1.3	4.5	0.4	0.3	1.2	0.1	-2.1	-1.3
Medication: Lisinopril	1.1	1.4	3.1	-1.7	-1.8	-0.9	-1.2	-0.1	-0.2
Heart disease (siblings)	1.1	1.4	3.2	-1.7	-0.8	0.1	-0.5	1.0	1.8
Reaction Time	1.0	2.0	7.0	-2.6	-1.5	-0.4	-0.9	-0.6	-1.2
Neuroticism	1.0	2.5	6.9	-1.8	-2.6	0.0	0.4	1.7	1.3
Medication: Co-codamol	1.0	1.1	2.4	-1.5	-1.5	0.9	-0.2	-1.0	-0.6
Hair/balding pattern: Pattern 2	1.0	1.3	3.7	-1.9	-1.1	-0.4	-1.0	1.2	0.2
Neuroticism score	1.0	2.0	5.2	-2.0	-2.3	-0.7	-0.6	1.1	0.7
Breastfed as a baby	1.0	1.2	3.6	-0.0	0.8	-1.9	-1.7	-0.0	-0.3
Commuting to job workplace: Walk	1.0	1.1	3.4	-0.8	0.3	-1.8	-1.3	0.7	0.7
Medication: Aspirin	1.0	1.3	4.7	0.2	0.8	-2.2	-0.9	1.1	0.7
Tinnitus: Yes, now most or all of the time	1.0	1.1	3.2	1.8	0.5	-0.7	-0.4	0.0	1.6
Alzheimer’s Disease (in father)	0.9	1.0	2.7	0.8	1.6	-0.2	0.3	0.1	-1.5
Verbal and Numeric Reasoning (VNR)	0.9	2.3	4.5	1.8	0.8	1.2	1.6	1.2	2.1
Breast Cancer	0.9	2.3	5.6	1.7	1.1	0.7	0.9	1.6	2.4
Blood White Count	0.9	6.4	14.1	0.7	3.2	-0.5	-2.9	-3.8	-2.2
Relative age voice broke	0.9	1.4	2.4	-1.4	-1.4	1.3	0.4	0.3	1.6
Serious illness, injury or assault to yourself	0.9	1.1	3.7	-0.7	-0.7	-0.2	-1.2	-0.7	-1.9
Sitting height	0.9	6.4	22.4	0.7	-0.4	-0.2	-0.8	-4.7	-3.9
Chronic bronchitis/emphysema (father)	0.9	1.1	2.9	-0.9	0.7	0.6	-0.6	-1.2	-1.7
Time employed in main current job	0.9	1.0	3.2	-1.8	-0.8	-0.9	-0.6	-0.8	-0.6
Age at first live birth	0.9	1.5	3.6	0.9	1.4	1.9	1.1	-1.0	-0.6
Neck or shoulder pain in last month	0.9	1.3	3.1	0.8	-1.3	0.2	0.9	1.8	1.3
Medication: Aspirin	0.9	1.2	3.3	0.2	0.8	-1.8	-0.7	1.2	1.1
Long-standing illness, disability or infirmity	0.9	1.4	5.4	-0.3	-0.8	0.4	0.3	-2.3	-1.4
Miserableness	0.9	1.5	2.9	-1.7	-1.7	-0.7	-0.6	1.5	0.1
Depressed Affect (Nagel 2018)	0.8	1.6	4.5	-1.8	-2.1	-0.5	-0.3	1.2	-0.2
Neuroticism (Nagel 2018)	0.8	1.9	5.3	-2.3	-2.0	-0.2	-0.1	1.3	0.2
Schizophrenia vs Biploar Disorder	0.8	1.0	3.0	-1.4	-1.7	0.1	0.7	0.7	0.2
Allergy or Eczema	0.8	2.1	7.9	0.4	0.2	-0.8	0.2	2.8	1.9
Qualifications: None of the above	0.8	1.7	5.1	-0.1	0.5	-0.3	-0.4	-2.2	-2.2
Falls in the last year	0.8	1.1	2.4	-0.1	-1.3	1.5	0.7	-1.4	-0.5
Noisy workplace	0.8	1.0	3.2	-0.2	-0.2	-1.8	-1.4	0.8	-0.2
Medication: Blood pressure	0.8	1.3	2.9	-1.4	-0.1	-1.6	-1.7	0.2	-0.7
Medication: Allopurinol	0.8	1.0	2.0	1.1	1.0	1.3	1.4	-0.3	0.5
Age at last live birth	0.8	1.1	2.4	1.0	1.5	1.5	1.0	0.4	0.5
Supplements: Vitamin C	0.8	1.0	2.3	-1.5	-0.4	-0.5	-1.4	-0.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	5.8	1.2	0.8	0.1	0.2	-2.4	-1.4
Leg fat-free mass (right)	0.8	4.5	12.0	1.8	0.3	0.8	1.0	-3.1	-3.5
Back pain experienced in last month	0.8	1.2	2.0	1.1	1.3	-1.4	-1.1	0.8	0.3
Breast cancer (self-reported)	0.8	1.0	2.2	-0.4	-0.9	-0.7	-1.5	-0.8	-1.2
Smoking status: Current	0.8	1.3	2.6	1.5	1.2	-1.6	-1.0	0.1	-0.6
Leg predicted mass (right)	0.8	4.5	12.2	1.8	0.3	0.8	1.0	-3.1	-3.5
Hearing aid user	0.8	0.9	2.6	-0.9	-0.6	-0.8	-0.2	1.6	0.8
Mother’s age at death	0.8	1.0	3.2	-0.4	-1.8	0.3	0.3	1.1	1.2
Commuting to job workplace: Cycle	0.8	1.0	2.4	0.3	-0.2	-1.1	-1.5	-0.8	-1.3
Basal cell carcinoma (self-reported)	0.8	1.0	1.5	1.0	1.1	0.1	0.9	1.2	1.1
Schizophrenia (2018)	0.7	1.4	4.5	-0.6	-0.6	2.1	1.6	-0.6	-0.2
Alzheimer’s Disease (including proxy)	0.7	1.0	2.8	0.1	0.9	0.4	1.7	1.5	-0.3
HbA1C	0.7	0.8	1.8	-1.1	-1.1	1.4	0.8	0.3	0.3
BMI	0.7	4.2	15.2	-0.0	-1.4	0.7	2.1	3.9	1.8
Number of treatments/medications taken	0.7	1.3	2.0	-0.9	-0.5	-1.4	-1.3	-1.1	-1.4
Sensitivity / hurt feelings	0.7	1.2	3.4	-1.4	-0.8	1.8	1.0	0.2	-0.5
Hearing difficulty/problems: Yes	0.7	1.0	2.4	1.0	0.3	1.4	1.5	0.3	0.9
Medication for hormone replacement therapy	0.7	0.8	2.1	1.4	1.0	-0.2	-0.5	-1.2	0.1
Leg fat-free mass (left)	0.7	3.9	11.0	1.5	0.1	1.0	1.1	-2.9	-3.3
Current tobacco smoking	0.7	1.2	2.8	1.7	1.2	-1.4	-0.8	0.2	-0.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.6	-1.2	-1.3	-0.1	-0.2	-0.4	-1.1
Body mass index (BMI)	0.7	2.9	11.0	-0.1	-1.3	0.5	1.5	3.3	1.5
Leg predicted mass (left)	0.7	3.9	10.6	1.5	0.0	1.0	1.2	-2.8	-3.3
Forced vital capacity (FVC)	0.7	2.8	6.5	2.5	1.3	1.3	1.2	-1.7	-1.6
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.8	0.5	0.0	1.0	1.0	-1.0	-1.4
Exposure to tobacco smoke at home	0.7	0.8	1.4	-0.6	-1.2	1.0	0.5	-0.9	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.1	-1.4	-1.4	0.3	0.5	1.4	0.3
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.9	-1.0	0.3	1.4	1.3	0.4	0.5
Loud music exposure frequency	0.7	0.7	1.9	-0.4	-0.3	-1.2	-0.8	1.4	0.5
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.9	-0.2	0.2	-1.3	-1.7	-0.3	-1.0
Forced vital capacity (FVC), Best measure	0.7	2.7	4.8	2.2	1.2	1.7	1.9	-1.2	-1.3
Diabetes diagnosed by doctor	0.7	1.2	2.1	1.4	1.2	-0.9	-0.7	-0.4	-1.4
Qualifications: nursing, teaching	0.7	1.2	5.3	0.1	-0.1	-0.3	-0.2	2.3	1.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	3.3	1.8	0.6	-1.1	-0.9	-0.7	-0.0
Number of operations (self-reported)	0.7	1.1	2.9	-0.4	-0.8	-1.3	-1.7	-0.0	-1.0
Pain experienced in last month	0.7	1.1	3.3	-0.8	1.0	1.8	1.0	-0.8	-0.2
Supplements: Calcium	0.7	0.8	2.3	-0.8	-1.5	-0.0	0.6	1.0	-0.8
Worry (Nagel 2018)	0.6	1.2	2.4	-1.4	-1.5	-0.0	0.6	1.0	1.2
Mean Putamen Volume	0.6	0.7	1.8	0.4	-0.3	-1.2	-0.7	-0.1	-1.3
Chronotype (morning person)	0.6	1.3	3.3	-1.8	-1.6	0.3	0.2	-0.1	-1.3
Relative age of first facial hair	0.6	1.2	2.1	-1.4	-1.1	1.0	0.3	1.4	1.0
Medication: Metformin	0.6	0.9	2.6	1.4	1.6	-0.3	-0.3	0.6	-0.5
Diabetes (father)	0.6	0.7	2.0	-1.0	-0.6	1.4	0.7	-0.4	0.7
Diabetes (mother)	0.6	0.8	2.5	-1.1	-1.6	0.9	0.1	-0.5	-0.5
Severe depression (siblings)	0.6	0.6	1.6	-0.4	0.0	1.3	0.8	0.7	0.9
Hearing difficulty/problems with background noise	0.6	0.9	1.9	0.0	-0.9	0.7	1.2	0.9	1.4
Trunk fat-free mass	0.6	3.5	7.1	2.0	0.9	0.3	1.3	-2.7	-2.7
Prospective memory result	0.6	0.7	1.7	-1.0	-0.4	-0.1	-0.5	-1.0	-1.3
Trunk predicted mass	0.6	3.5	7.5	2.0	0.9	0.3	1.3	-2.7	-2.7
Chronic bronchitis/emphysema (mother)	0.6	0.7	3.1	-0.2	-0.3	0.3	-0.5	-1.8	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	-1.2	-1.0	1.2	0.0	-0.5	-0.7
Migraine (self-reported)	0.6	0.7	1.4	0.2	-0.7	-1.0	-0.1	1.1	1.2
Medication: Omeprazole	0.6	0.8	1.6	-0.1	-1.1	-1.1	-0.2	1.2	0.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	3.0	-0.5	0.5	-0.3	-0.4	0.7	1.7
Whole body fat-free mass	0.6	3.6	8.4	2.0	0.6	0.5	1.3	-2.7	-2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	4.5	1.2	0.6	-0.1	0.6	2.1	0.7
Whole body water mass	0.6	3.4	8.2	1.9	0.6	0.5	1.3	-2.6	-2.9
Medication: Bendroflumethiazide	0.6	1.0	2.0	-0.2	1.0	-1.1	-0.9	-0.8	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.7	0.5	-0.7	-1.3	-0.0	1.1	0.8
Bipolar Disorder or Schizophrenia	0.5	1.2	3.5	-0.4	-0.1	1.9	1.6	-0.6	-0.9
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.8	1.7	0.8	1.0	1.7	-0.2	1.4
Crohns Disease (2017)	0.5	1.0	4.2	0.3	-0.4	0.1	0.3	1.2	2.0
Prostate Cancer	0.5	0.7	1.4	-0.4	-1.2	1.2	0.9	-0.2	-0.4
Age at First Birth	0.5	0.8	1.5	1.0	0.9	0.9	1.2	0.7	0.0
Lupus	0.5	0.8	2.5	-1.6	-1.2	-0.6	-0.3	0.6	0.2
Lung FVC	0.5	2.8	4.6	2.1	1.1	1.5	2.1	2.0	0.5
Multivitamins +/- minerals	0.5	0.6	3.1	-0.4	-0.3	0.0	-0.3	-0.4	-1.8
Past tobacco smoking	0.5	0.8	1.4	1.1	1.1	1.0	1.2	-0.4	0.4
Alcohol usually taken with meals	0.5	0.9	2.7	-0.9	-1.6	-0.3	-0.3	1.0	0.8
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.5	0.5	-0.2	-1.2	-0.7	1.9	1.2
Depression (self-reported)	0.5	0.6	2.1	-0.0	-0.0	1.3	1.4	-0.0	-0.3
Blood clot in the leg (DVT)	0.5	0.6	2.5	-0.1	0.3	-1.6	-0.6	0.5	0.7
Gout (self-reported)	0.5	0.7	1.3	1.1	1.1	1.0	0.6	0.5	0.4
Comparative body size at age 10	0.5	1.5	3.2	-0.7	-0.8	-1.8	-1.3	1.6	-0.4
Health satisfaction	0.5	0.7	1.6	-0.1	0.0	1.3	1.2	-0.9	0.1
Leg fat mass (right)	0.5	1.8	5.0	-0.1	-1.7	0.6	1.6	2.2	0.4
Alcohol intake frequency.	0.5	1.1	1.9	-1.1	-1.4	1.2	1.2	-0.1	-0.6
Overall health rating	0.5	1.0	3.3	1.8	1.4	-0.1	0.0	-0.7	-0.1
Had major operations	0.5	0.6	1.8	1.3	0.6	-0.5	-0.9	-0.6	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.6	0.6	0.0	0.6	1.0	0.3	1.3
Mood swings	0.5	0.9	2.7	-1.6	-1.5	-0.3	-0.4	-0.1	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.4	-0.9	-1.2	-0.1	0.3	-0.1	-1.0
Osteoarthritis (self-reported)	0.5	0.7	1.9	1.4	-0.3	0.2	0.1	-1.1	-0.9
Wears glasses or contact lenses	0.5	0.6	1.4	-0.1	-0.3	-0.4	0.9	1.0	1.2
Ever taken oral contraceptive pill	0.5	0.6	1.9	-1.4	-0.4	0.8	-0.4	-0.4	-0.7
Financial situation satisfaction	0.5	0.6	1.7	0.8	0.9	0.5	0.5	0.2	-1.3
Basal metabolic rate	0.5	2.8	6.8	1.8	0.3	0.5	1.3	-2.2	-2.6
Leg fat mass (left)	0.5	1.8	5.3	-0.1	-1.7	0.5	1.5	2.3	0.3
Hand grip strength (right)	0.4	1.2	2.7	-1.1	-0.3	-1.3	-1.6	-0.5	-1.2
Fed-up feelings	0.4	0.7	2.4	-0.5	-1.5	-0.8	-0.6	0.4	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.2	-0.4	-1.5	-0.5	0.4	0.6	-0.2
Pain all over the body in last month	0.4	0.5	1.2	0.3	-0.7	0.7	1.1	-0.7	-0.0
Diabetes (self-reported)	0.4	0.6	1.2	0.7	0.4	-1.1	-0.8	0.0	-0.9
Hip circumference	0.4	1.7	4.0	1.7	-0.2	0.6	1.8	2.0	0.4
Alcohol intake versus 10 years previously	0.4	0.6	2.0	-0.6	-0.0	-0.0	-1.0	-0.7	-1.4
Worrier / anxious feelings	0.4	0.8	1.5	-0.9	-0.9	0.7	1.2	0.6	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.5	-1.0	-1.2	-0.5	-0.6	0.6	-0.2
Hair/balding pattern: Pattern 3	0.4	0.6	1.4	1.2	1.2	0.3	0.5	0.6	0.6
Happiness	0.4	0.5	2.1	-1.5	-0.3	0.3	0.3	-0.6	-0.5
Tense / ‘highly strung’	0.4	0.7	1.0	-0.8	-1.0	0.6	0.7	1.0	0.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.0	1.4	1.0	-0.7	0.3	1.0	0.4
Body fat percentage	0.4	1.5	4.5	-0.1	-1.7	0.5	1.0	2.1	0.3
Qualifications: College or University degree	0.4	1.4	4.0	-1.1	-0.6	0.2	-0.0	2.0	1.6
Medication for pain relief, constipation, heartburn	0.4	0.7	2.2	0.6	0.6	1.5	1.2	-0.2	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.9	-0.9	-0.9	-0.4	-0.9	-0.3	-0.1
Number of full sisters	0.4	0.5	2.0	0.5	1.4	-0.3	0.3	-0.4	-0.4
Smoking status: Previous	0.4	0.5	1.2	-1.1	-1.0	-0.3	-0.9	0.1	-0.2
Loneliness, isolation	0.4	0.6	1.2	-1.1	-1.0	-0.4	-0.8	0.7	0.1
Medication: Gliclazide	0.4	0.5	1.4	1.2	1.1	-0.2	-0.2	-0.3	-0.1
Fractured/broken bones in last 5 years	0.4	0.5	1.4	0.2	-0.1	1.1	0.6	-1.2	-0.1
Alcohol drinker status: Previous	0.4	0.4	1.0	-1.0	-0.8	0.7	-0.0	0.4	-0.4
Ulcerative Colitis (UC)	0.3	0.5	1.7	0.0	-0.0	0.9	0.6	-1.3	-0.3
Primary Biliary Cirrhosis	0.3	0.5	1.8	-1.3	0.6	0.5	0.5	-0.2	0.3
Schizophrenia (2014)	0.3	0.6	1.7	0.3	0.5	1.3	1.2	-0.5	0.1
Blood Eosinophil Count	0.3	2.4	6.5	2.5	1.8	0.7	1.1	0.0	1.7
Blood Platelet Count	0.3	3.9	13.0	3.6	1.9	0.1	0.5	-2.4	-1.1
Blood Red Count	0.3	2.8	6.5	-1.3	-0.3	0.7	-1.4	-2.5	-2.5
Heel T-Score	0.3	2.7	7.8	-2.8	-1.6	-1.5	-1.9	-0.6	-0.3
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.7	0.3	0.1	-0.6	-0.7	0.3	-1.3
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.3	0.1	-1.1	0.2	1.1	0.5	-0.0
Supplements: Zinc	0.3	0.3	0.5	-0.6	-0.4	0.4	0.6	0.7	-0.3
Pack years adult smoking proportion	0.3	0.5	0.8	0.6	0.4	0.6	0.9	0.9	0.6
Townsend deprivation index at recruitment	0.3	0.4	1.4	1.2	0.1	0.2	0.7	-0.5	-0.6
Taking other prescription medications	0.3	0.4	1.7	0.5	-0.5	-0.3	0.1	-1.3	-0.2
Stomach or abdominal pain in last month	0.3	0.4	1.6	-0.7	-1.3	0.1	-0.0	0.7	0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.5	0.3	-1.2	-0.2	0.1	-0.4	0.3
Medication: Levothyroxine sodium	0.3	0.4	1.0	0.7	0.4	-1.0	-0.3	1.0	0.1
Financial difficulties in last 2 years	0.3	0.4	1.2	1.1	0.5	-0.3	0.0	-0.1	-1.1
Medication: Paracetamol	0.3	0.5	1.4	-0.8	-1.2	0.5	-0.2	-0.4	-0.8
Headache pain in last month	0.3	0.4	1.5	0.6	-0.2	0.6	1.2	-0.6	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.1	0.1	0.3	0.6	0.6	0.3	-1.1
Mean time to correctly identify matches	0.3	0.6	1.6	-1.3	-0.3	0.2	-0.1	-1.1	-1.0
Arm predicted mass (right)	0.3	1.3	3.2	1.8	0.4	-0.2	1.2	-0.9	-1.6
Chest pain or discomfort	0.3	0.4	1.6	-0.2	-1.3	-0.1	0.1	-0.8	0.2
Ever had bowel cancer screening	0.3	0.3	1.5	0.4	0.4	-0.3	0.4	-1.2	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	-0.5	-0.4	0.2	0.5	0.6	0.9
Friendships satisfaction	0.3	0.4	1.1	0.5	0.5	1.0	0.4	-0.7	-0.5
Ever smoked	0.3	0.6	1.0	-0.7	-1.0	-1.0	-1.0	0.3	-0.2
Arm fat-free mass (left)	0.3	1.3	3.2	1.8	0.5	0.1	1.3	-0.8	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	0.1	0.3	-1.1	-0.0	0.5	0.9
Impedance of whole body	0.3	1.6	5.3	-0.6	-0.6	-0.6	-1.6	-2.3	-1.0
Arm predicted mass (left)	0.3	1.7	4.1	2.0	0.8	0.1	1.4	-1.0	-1.6
Bipolar Disorder (2018)	0.2	0.4	1.5	-0.2	0.7	0.3	0.5	-0.2	-1.2
Irritable Bowel Disease (IBD)	0.2	0.5	1.6	0.2	-0.4	0.6	0.7	0.2	1.2
Hand grip strength (left)	0.2	0.4	1.5	-0.7	0.3	-0.4	-0.3	-0.4	-1.2
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.0	-1.0	-0.4	0.6	0.1	-0.2	0.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.7	0.7	-0.2	0.4	0.8	-0.5	0.1
Impedance of leg (right)	0.2	1.0	2.4	-1.5	-1.2	-0.7	-0.9	0.2	0.9
Trunk fat percentage	0.2	0.7	2.3	0.2	-1.5	0.4	0.6	0.9	-0.7
Age when periods started (menarche)	0.2	0.5	1.4	0.6	0.5	1.2	0.5	-0.8	-0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	-0.6	-0.8	0.3	0.1	-0.5	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.1	-1.1	0.1	-0.5	-0.6	1.0	0.5
Impedance of leg (left)	0.2	1.0	1.6	-1.1	-0.9	-1.1	-1.0	0.7	1.3
Trunk fat mass	0.2	0.9	1.9	0.5	-1.4	0.5	1.0	0.2	-1.3
Waist circumference	0.2	0.8	2.8	0.9	-0.0	0.9	1.7	0.4	0.5
Mouth/teeth dental problems	0.2	0.3	0.6	-0.6	0.4	0.8	0.3	-0.2	0.7
Weight	0.2	1.2	2.4	1.2	-0.7	0.8	1.5	-0.5	-1.3
Arm fat percentage (right)	0.2	0.7	1.6	0.1	-1.1	0.8	0.9	1.3	-0.1
Medication: Lansoprazole	0.2	0.2	0.5	-0.4	-0.7	-0.2	0.2	-0.5	0.3
Arm fat-free mass (right)	0.2	1.2	3.0	1.7	0.2	-0.1	1.3	-0.6	-1.4
Emphysema/chronic bronchitis	0.2	0.2	0.8	-0.2	0.7	-0.1	0.3	-0.0	0.9
Whole body fat mass	0.2	0.9	1.9	0.3	-1.4	0.7	1.3	0.7	-0.9
Illnesses of siblings: Diabetes	0.2	0.2	0.6	-0.2	-0.7	0.2	-0.1	-0.4	-0.8
Arm fat percentage (left)	0.2	1.0	2.5	-0.1	-1.6	0.4	0.8	1.6	-0.1
Average weekly red wine intake	0.2	0.3	0.7	-0.3	-0.7	-0.7	-0.9	-0.2	-0.2
Mineral and other dietary supplements	0.2	0.3	0.8	-0.9	-0.5	0.4	-0.2	0.1	0.7
Number of self-reported non-cancer illnesses	0.2	0.3	1.0	-0.5	-0.7	0.2	0.4	-0.2	1.0
Average weekly champagne plus white wine intake	0.2	0.2	0.4	0.7	0.6	-0.4	-0.2	0.7	0.1
Commuting to job workplace: Public transport	0.2	0.2	0.6	0.3	-0.5	0.8	-0.3	-0.5	0.3
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.0	1.0	0.5	-0.3	0.2	0.3	-0.6
Irritability	0.2	0.4	1.4	-0.1	-0.5	-1.2	-0.2	-0.5	0.7
Unable to work because of sickness or disability	0.2	0.3	1.5	0.3	-0.0	-0.1	0.3	-0.3	-1.2
Pack years of smoking	0.2	0.4	1.0	0.4	0.3	0.3	0.7	1.0	0.6
Major Depression (MDD)	0.1	0.2	0.3	0.1	0.4	-0.4	0.5	0.4	0.6
Fasting Glucose	0.1	0.1	0.4	-0.6	-0.0	0.1	-0.0	0.2	0.4
Ulcerative Colitis	0.1	0.2	1.0	-0.1	0.5	-0.0	-0.3	-0.0	1.0
Smoking Status	0.1	0.1	0.5	0.3	0.3	-0.7	-0.2	0.2	-0.3
Hypothyroidism (self reported)	0.1	0.2	0.9	0.2	0.0	-0.4	0.1	0.9	-0.4
Hair Pigment	0.1	2.9	5.8	-2.0	0.0	2.3	1.0	2.4	1.1
Tanning	0.1	1.0	2.1	-0.7	0.0	-1.1	-1.4	0.7	1.2
Maternal smoking around birth	0.1	0.2	0.4	0.1	0.6	0.2	-0.3	-0.3	-0.6
Number of incorrect matches in round	0.1	0.1	0.3	-0.0	-0.6	-0.1	0.4	-0.1	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.7	0.3	0.0	-0.6	0.3	-0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.6	1.3	-0.0	0.0	0.0	-0.0	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.7	0.8	-0.2	0.3	0.4	0.6	-0.7
Arm fat mass (right)	0.1	0.6	1.0	0.6	-0.9	0.4	1.0	0.9	-0.5
Exposure to tobacco smoke outside home	0.1	0.2	0.6	0.0	0.5	-0.5	-0.8	0.1	0.3
Worry too long after embarrassment	0.1	0.1	0.5	0.0	-0.1	0.0	-0.4	0.3	0.7
Number of children fathered	0.1	0.2	0.4	-0.3	-0.6	-0.0	0.4	-0.2	0.6
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.2	-0.0	0.6	-0.3	0.4	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.6	-0.8	-0.0	0.3	-0.0	-0.2	-0.4
Arm fat mass (left)	0.1	0.6	1.0	0.4	-1.0	0.3	0.9	1.0	-0.7
Medication: Paracetamol	0.1	0.2	0.4	0.0	-0.7	-0.2	-0.6	-0.2	-0.7
Ever depressed for a whole week	0.1	0.1	0.2	0.1	-0.2	0.5	0.4	-0.4	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Family relationship satisfaction	0.0	0.1	0.1	0.2	0.3	-0.2	0.0	0.2	0.3

Hub : Genes

KANK2

Models

Trait associations