Hub : Genes

DOCK6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1280	0.0460	2.6e-04	0.100	NA	0.053	NA	0.074	1.6e-08	NA	3.8e-05	NA	1.1e-06
2	GTEx	Brain Cerebellar Hemisphere	0.3680	0.1120	5.0e-03	-0.004	NA	-0.003	NA	0.007	4.2e-01	NA	3.9e-01	NA	2.1e-01
3	GTEx	Skin Sun Exposed Lower leg	0.1510	0.0480	9.5e-04	0.115	NA	0.057	NA	0.085	9.6e-10	NA	1.8e-05	NA	1.6e-07
4	GTEx	Thyroid	0.1040	0.0410	2.3e-03	0.040	NA	0.027	NA	0.042	4.8e-04	NA	3.3e-03	NA	3.4e-04
5	TCGA	Brain Lower Grade Glioma	0.0759	0.0323	3.2e-04	0.012	0.037	0.045	NA	0.037	1.5e-02	4.0e-05	7.2e-06	NA	4.2e-05
6	TCGA	Thyroid Carcinoma	0.1700	0.0540	2.8e-09	0.112	0.095	0.107	NA	0.105	5.1e-11	1.5e-09	1.6e-10	NA	2.0e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.1	0.2	0.5	-0.0	-0.7	0.2	-0.0	0.1	-0.7
Bipolar Disorder or Schizophrenia	0.5	1.2	1.8	-1.3	-0.9	-1.3	-0.4	-1.3	0.9
Depressed Affect (Nagel 2018)	0.1	0.1	0.5	0.2	0.7	0.1	-0.2	-0.5	-0.3
Depression (Nagel 2018)	0.5	0.8	1.6	-1.3	0.2	-1.2	-1.1	-0.1	0.1
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.0	-0.1	1.0	0.5	0.9	-0.9	0.8
Neuroticism (Nagel 2018)	0.1	0.3	0.5	-0.7	0.7	-0.4	-0.6	-0.3	-0.1
Schizophrenia (2018)	1.0	2.0	3.6	-1.7	-0.5	-1.9	-0.5	-1.6	1.7
Schizophrenia vs Biploar Disorder	0.5	0.7	1.7	-0.8	0.1	-1.0	-0.4	0.7	1.3
Worry (Nagel 2018)	0.3	0.6	1.7	-1.3	0.9	-0.8	-0.3	-0.7	0.5
Alzheimer’s Disease (in mother)	1.0	1.2	3.7	0.6	0.1	1.3	1.2	-1.9	-0.3
Alzheimer’s Disease (in father)	0.7	0.8	3.2	0.9	0.3	0.6	0.3	0.1	-1.8
Alzheimer’s Disease (including proxy)	1.0	1.4	2.5	0.9	-0.0	1.4	1.0	-1.6	-1.5
Crohns Disease (2017)	1.6	3.6	8.0	-2.8	0.0	-2.4	-2.4	1.2	-0.6
Irritable Bowel Disease (IBD)	1.0	2.4	6.8	-2.6	-0.3	-2.2	-1.6	0.2	0.4
Ulcerative Colitis (UC)	0.2	0.5	1.0	-0.6	-0.3	-0.5	0.2	-1.0	1.0
Major Depression (MDD)	0.1	0.2	0.7	-0.2	0.8	0.3	0.2	0.5	-0.0
Reaction Time	1.4	2.7	6.4	-1.0	-2.5	-0.8	-1.4	-1.1	-2.2
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.6	1.1	0.8	1.2	1.6	-1.0	1.1
Breast Cancer	1.3	3.1	6.1	1.3	2.5	1.7	2.3	0.3	1.6
Ovarian Cancer	1.3	1.7	4.3	-2.1	-1.0	-1.3	-0.7	1.0	1.4
Prostate Cancer	0.1	0.2	0.6	-0.5	0.1	-0.2	-0.3	-0.5	-0.8
Age at First Birth	1.0	1.5	3.4	-1.2	-0.4	-1.4	-1.8	1.0	-1.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	-0.5	-0.8	-0.5	-0.6	-0.6	0.2
Coronary Artery Disease (CAD)	0.8	1.0	1.9	0.5	1.3	0.8	1.2	0.4	1.4
Crohns Disease (2012)	0.7	1.1	2.3	-1.5	-0.6	-1.1	-0.9	1.2	0.2
Mean Putamen Volume	0.3	0.3	1.0	-0.2	-0.2	-0.5	-0.8	0.2	-1.0
Fasting Glucose	1.8	2.2	5.2	1.3	-0.4	1.2	1.7	-2.3	1.4
HbA1C	2.0	2.2	2.9	-1.4	-1.2	-1.6	-1.7	-1.6	-1.4
HDL Cholesterol	0.9	1.4	4.1	2.0	1.1	1.0	0.8	1.2	-0.5
LDL Cholesterol	4.5	7.1	30.0	-0.6	1.2	-0.1	-1.7	5.5	-2.8
Lupus	0.1	0.1	0.4	-0.1	0.4	0.4	0.3	0.1	0.7
Neuroticism (2016)	2.7	3.9	7.7	2.6	0.2	2.8	1.3	-1.0	-2.5
Primary Biliary Cirrhosis	1.7	2.5	4.7	-1.9	-0.4	-2.0	-2.2	1.3	-0.9
Rheumatoid Arthritis	1.3	1.8	5.8	0.2	0.7	0.1	-0.5	-2.4	-2.0
Schizophrenia (2014)	0.8	1.7	5.1	-1.6	-0.1	-1.6	-0.2	-0.6	2.2
Triglycerides	0.4	0.7	1.1	-0.7	-1.0	-0.3	-0.8	1.0	-0.9
Type 2 Diabetes (T2D) (2012)	0.7	0.9	1.9	-1.3	0.6	-1.4	-0.4	0.0	1.0
Ulcerative Colitis	0.4	0.6	2.9	-0.3	0.2	-0.0	0.7	-0.2	1.7
Blood Eosinophil Count	0.6	4.3	6.4	1.5	1.8	1.2	2.5	-2.5	2.5
Blood Platelet Count	0.8	9.0	21.5	2.6	1.3	1.9	3.9	-2.3	4.6
Blood Red Count	0.2	2.3	6.5	0.6	1.3	0.2	1.4	-1.8	2.5
Blood White Count	1.0	7.5	20.6	0.8	3.9	0.6	2.8	-0.3	4.5
Heel T-Score	0.3	2.3	6.8	1.5	0.1	1.4	1.3	-2.6	1.0
BMI	0.1	0.5	1.2	0.4	-1.0	-0.4	-1.1	0.7	-0.6
Height	0.1	2.6	6.8	-2.3	-0.1	-2.6	-1.9	0.4	-0.1
Waist Hip Ratio (WHR)	0.6	2.9	6.9	-1.3	1.9	-0.4	1.4	-1.8	2.6
Systolic Blood Pressure	2.8	14.0	26.9	5.0	-0.5	5.0	5.2	-2.7	0.6
Smoking Status	0.1	0.1	0.5	0.2	-0.7	0.3	0.2	0.3	-0.0
Allergy or Eczema	0.4	0.9	2.0	1.0	-0.1	1.2	1.1	-1.4	-0.1
Cardiovascular Disease	2.0	6.7	13.7	3.7	-1.4	3.6	2.3	-0.5	-2.5
Hypothyroidism (self reported)	0.4	0.9	1.6	-1.3	0.8	-1.0	-1.0	-0.9	-0.7
Respiratory disease	0.9	2.0	5.3	0.7	1.6	0.4	1.3	-2.3	1.3
Type 2 Diabetes (T2D) (2018)	0.8	1.4	2.3	-1.4	-1.5	-1.4	-1.4	0.0	-0.2
Lung FEV1/FVC ratio	0.5	2.8	6.6	-0.2	-1.5	-0.9	-2.6	0.8	-2.5
Lung FVC	0.1	0.5	2.4	-0.1	-1.5	-0.5	-0.3	0.2	0.3
Neuroticism	0.1	0.2	0.8	-0.3	0.5	0.2	-0.0	-0.9	-0.1
Chronotype (morning person)	0.6	1.3	4.4	-0.9	-1.2	-0.6	-0.4	-2.1	-1.0
Hair Pigment	0.2	4.8	12.5	1.9	-0.5	2.5	2.4	-3.5	-0.9
Tanning	0.2	1.9	3.1	-1.6	1.6	-1.3	-0.8	1.8	1.0
Hand grip strength (left)	0.3	0.7	1.5	-1.2	-0.4	-1.1	-1.1	0.1	-0.7
Number of treatments/medications taken	0.0	0.1	0.2	0.2	0.0	0.3	0.4	-0.2	0.3
Average weekly spirits intake	0.8	0.9	4.7	0.4	-0.4	0.3	0.7	0.2	2.2
Sensitivity / hurt feelings	0.5	0.9	1.7	-1.3	0.7	-1.0	-1.3	0.7	-0.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	-0.6	-0.7	-0.6	-0.6	-0.3	0.2
Hearing difficulty/problems: Yes	0.2	0.3	0.6	-0.8	0.3	-0.8	-0.6	0.4	0.2
Relative age of first facial hair	1.0	2.1	7.2	1.6	0.3	1.4	0.1	-0.8	-2.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	1.1	-0.0	0.2	0.1	-0.4	1.1	-0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	-0.8	-0.7	-0.4	-0.4	-0.8	-0.6
Ever had hysterectomy (womb removed)	0.7	0.8	2.9	0.5	-1.7	0.7	0.0	-0.2	-1.0
Systolic blood pressure, automated reading	4.0	11.6	23.6	4.3	0.8	4.2	4.9	-2.6	1.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.9	-0.3	0.6	-0.5	-0.9	-0.0	-0.9
Angina	0.8	1.1	4.1	0.7	0.4	0.8	-0.2	2.0	-1.1
Medication for hormone replacement therapy	0.4	0.4	1.7	-0.2	0.1	0.0	0.3	1.3	0.8
Vitamin and mineral supplements	1.6	2.1	3.6	-1.5	-1.9	-1.3	-1.7	1.3	-0.7
Supplements: Zinc	0.9	0.9	1.2	0.9	0.9	1.0	0.8	-1.1	-1.0
Medication: Co-codamol	0.9	1.1	1.7	-1.1	-1.3	-1.1	-0.8	-1.2	-0.4
Medication: Metformin	1.3	1.8	2.9	-1.6	-1.0	-1.5	-1.3	1.7	0.8
Diabetes (father)	1.9	2.3	3.5	1.9	0.9	1.8	1.8	-1.7	0.7
Diabetes (mother)	0.6	0.8	1.3	-1.1	-0.4	-1.1	-0.9	-1.2	-0.1
Severe depression (siblings)	0.3	0.3	0.7	0.4	0.1	0.7	0.6	0.6	0.8
Pack years adult smoking proportion	0.4	0.6	2.0	0.4	0.8	0.7	0.5	1.4	-0.2
Impedance of leg (right)	0.7	3.6	8.7	1.2	1.3	1.8	2.4	-2.9	0.9
Leg fat-free mass (left)	0.6	3.1	6.6	-1.6	-1.4	-2.5	-2.6	0.8	-0.5
Trunk fat percentage	0.1	0.6	2.2	0.1	-1.5	-0.3	-0.5	-0.8	0.4
Hand grip strength (right)	0.5	1.3	2.1	-1.3	-1.2	-1.2	-1.4	-0.3	-0.9
Townsend deprivation index at recruitment	0.4	0.6	1.3	0.8	-1.1	0.9	0.4	-0.8	-0.5
Current tobacco smoking	0.2	0.4	1.1	0.8	-0.1	0.6	0.5	1.1	-0.2
Average weekly fortified wine intake	1.5	1.7	3.5	-1.4	-1.4	-1.1	-1.3	1.9	0.1
Maternal smoking around birth	0.3	0.5	2.6	0.2	0.0	0.4	0.0	1.6	0.3
Fed-up feelings	0.4	0.7	2.0	1.4	0.7	1.1	0.7	-0.1	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.9	-1.0	0.5	-0.8	-0.8	-0.3	-0.1
Relative age voice broke	0.1	0.2	0.6	0.2	-0.1	0.2	-0.4	0.5	-0.8
Taking other prescription medications	0.1	0.2	1.1	0.2	-0.3	0.2	0.1	-1.1	-0.2
Age when periods started (menarche)	0.4	0.9	1.7	0.0	1.2	0.2	0.9	-1.1	1.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	-0.5	0.4	-0.5	0.3	-0.3	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	3.8	0.2	-0.4	0.4	0.6	-0.1	2.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	-0.5	-0.9	-0.5	-0.5	-1.0	-0.4
Qualifications: CSEs or equivalent	2.5	3.3	6.1	-2.0	2.5	-2.1	-0.8	-1.2	1.8
Serious illness, injury or assault to yourself	0.4	0.5	1.7	0.2	-0.4	-0.3	-0.5	0.7	-1.3
High blood pressure	2.5	6.9	12.7	3.6	-2.0	3.3	2.7	-2.3	-1.2
Hayfever, allergic rhinitis or eczema	0.9	1.9	4.3	1.1	0.2	1.5	1.9	-2.1	0.3
Multivitamins +/- minerals	0.8	1.1	1.5	1.0	1.2	0.9	1.2	-1.2	0.6
Stomach or abdominal pain in last month	1.2	1.6	3.1	-0.9	0.2	-1.4	-1.8	-1.1	-1.4
Supplements: Glucosamine	1.1	1.5	4.0	1.5	2.0	1.0	0.5	0.8	-0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	-0.0	-1.3	-0.5	-0.4	-1.0	-0.8
Medication: Atenolol	0.2	0.3	0.5	0.3	-0.4	0.7	0.7	-0.6	0.4
Medication: Levothyroxine sodium	0.5	0.9	4.8	0.1	2.2	0.6	0.5	0.1	0.3
Sitting height	0.2	1.4	3.0	-1.5	0.9	-1.3	-0.2	-0.6	1.7
Chronic bronchitis/emphysema (father)	4.1	4.8	9.5	-3.0	-2.0	-3.1	-2.4	0.4	0.7
High blood pressure (mother)	1.3	1.8	4.0	1.4	-2.0	1.3	0.6	-1.3	-1.0
Body mass index (BMI)	0.2	0.8	3.1	0.9	-1.7	0.1	-0.7	-0.3	-0.7
Impedance of leg (left)	0.5	2.3	5.4	0.3	1.3	1.1	1.9	-2.3	1.3
Leg predicted mass (left)	0.6	3.1	6.9	-1.6	-1.3	-2.5	-2.6	0.8	-0.6
Trunk fat mass	0.2	0.9	2.8	-0.3	-1.7	-1.0	-1.2	-0.4	0.1
Waist circumference	0.1	0.3	1.3	0.2	-1.1	-0.4	-0.6	-0.3	0.2
Number of incorrect matches in round	0.4	0.6	2.1	-1.4	0.5	-1.0	-0.4	0.1	0.5
Past tobacco smoking	0.4	0.8	3.0	0.5	1.7	0.4	-0.0	0.4	-1.2
Alcohol usually taken with meals	1.7	2.8	5.3	-1.2	-1.8	-1.3	-2.3	0.1	-2.3
Nervous feelings	0.3	0.6	2.9	-0.5	0.2	0.0	0.6	-1.7	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	5.1	0.3	-1.4	0.2	0.1	-2.3	-0.4
Hearing difficulty/problems with background noise	0.1	0.2	0.7	-0.5	-0.5	-0.2	-0.2	-0.8	-0.1
Hair/balding pattern: Pattern 2	1.8	2.3	4.4	-1.0	-2.1	-1.2	-1.8	-0.2	-1.9
Had menopause	0.3	0.4	0.7	0.7	0.1	0.6	0.3	-0.8	-0.8
Had other major operations	0.4	0.5	1.5	-0.3	-1.2	-0.5	-0.9	0.2	-0.5
Forced vital capacity (FVC)	0.3	1.3	3.0	-1.5	-0.4	-1.7	-1.2	0.9	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	5.3	-0.3	-0.0	-0.5	0.2	-0.6	2.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.2	-0.5	0.3	-0.7	-0.3	-1.1	-0.3
Qualifications: None of the above	0.1	0.1	0.4	-0.1	-0.6	-0.1	-0.3	0.1	-0.4
Financial difficulties in last 2 years	0.5	0.7	1.7	1.0	-1.3	0.7	0.9	-0.3	0.5
Mouth/teeth dental problems	0.8	1.2	2.3	-1.4	0.7	-1.5	-1.1	0.8	0.5
Heart attack	1.3	1.7	4.8	1.2	1.3	1.4	0.8	2.2	0.2
Allergy	0.8	1.8	5.9	-0.5	-0.3	-0.8	-1.6	2.4	-1.0
Pain all over the body in last month	0.2	0.2	0.4	0.7	0.4	0.6	0.2	-0.3	-0.6
Diabetes (self-reported)	0.4	0.6	1.0	-1.0	-0.7	-1.0	-1.0	0.4	0.0
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.5	0.5	0.5	0.7	1.6	-1.6	1.3
Medication: Ramipril	0.8	1.0	2.2	1.3	-0.8	1.5	0.9	-0.1	-0.8
Medication: Simvastatin	0.9	1.3	3.7	0.4	-0.6	0.9	-0.3	1.9	-1.7
Fluid intelligence score	2.1	4.3	7.8	2.5	2.1	2.8	2.6	-0.8	0.2
Illnesses of siblings	0.6	0.9	2.1	-0.7	0.1	-1.3	-0.9	1.5	0.5
Neuroticism score	0.1	0.1	0.4	-0.1	0.7	0.4	-0.1	-0.2	-0.5
Weight	0.3	1.5	3.4	-0.6	-1.7	-1.5	-1.8	-0.1	-0.5
Impedance of arm (right)	0.2	1.0	3.1	0.4	0.3	0.8	1.4	-1.8	0.4
Arm fat percentage (right)	0.2	0.7	3.3	0.7	-1.8	-0.0	-0.4	-0.5	-0.1
Trunk fat-free mass	0.5	2.9	6.3	-1.6	-0.8	-2.5	-2.5	1.2	-0.5
Hip circumference	0.2	1.0	3.6	0.6	-1.9	-0.6	-1.1	0.5	-0.4
Time employed in main current job	0.1	0.2	0.5	0.3	-0.7	0.4	0.2	-0.3	-0.4
Alcohol intake versus 10 years previously	0.3	0.5	1.5	0.6	1.2	0.4	0.5	-0.8	0.0
Father’s age at death	0.5	0.7	1.9	-1.4	-0.4	-1.2	-0.8	-0.6	0.1
Worrier / anxious feelings	0.6	1.2	4.9	-0.6	0.6	-0.1	-1.2	-0.5	-2.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.5	-1.2	1.1	-0.9	-0.2	0.7	1.6
Falls in the last year	0.3	0.4	1.0	1.0	0.4	0.9	0.7	-0.3	0.2
Hair/balding pattern: Pattern 3	0.5	0.7	1.3	0.9	0.3	1.2	0.9	1.1	0.3
Number of live births	0.5	0.8	2.1	-1.4	0.1	-1.0	-1.1	0.4	0.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	3.6	-1.4	-0.4	-1.9	-1.7	0.6	-0.1
Pulse rate	0.6	1.1	2.2	-1.5	0.6	-1.4	-0.2	0.3	1.3
Happiness	0.6	0.7	3.8	-0.5	0.3	-0.5	-0.0	-1.9	0.3
Noisy workplace	1.5	1.9	3.6	1.9	-1.1	1.8	1.7	-0.5	0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.3	0.0	1.2	0.1	0.1	0.6	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.2	-0.6	-0.5	-0.6	-0.9	-1.1	-1.5
Mouth/teeth dental problems: Dentures	1.6	2.7	5.9	2.1	-0.3	2.4	2.2	-1.0	0.1
Asthma	1.2	2.5	5.1	0.6	1.9	0.2	1.6	-2.3	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.5	-1.1	-1.0	-1.1	-1.2	-0.3	-0.2
Medication: Cholesterol lowering	1.9	2.9	11.6	1.3	0.1	1.8	0.7	3.4	-0.5
Depression (self-reported)	0.7	0.8	1.9	-0.3	1.4	-0.0	0.5	-1.2	1.2
Medication: Lansoprazole	1.7	1.9	4.9	1.9	-0.7	1.4	0.1	-0.9	-2.2
Prospective memory result	0.4	0.5	1.4	-0.4	-0.8	-0.6	-0.8	1.2	-0.1
Lung cancer (father)	0.9	1.0	3.8	0.8	-0.8	0.8	0.2	-0.8	-1.9
Illnesses of mother	1.1	1.3	2.3	-1.3	1.4	-1.5	-1.1	0.8	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	5.8	-1.8	-0.5	-2.2	-2.4	0.5	-0.7
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	-0.6	0.7	-0.7	-0.6	-0.1	-0.2
Impedance of arm (left)	0.2	1.0	3.5	-0.0	0.3	0.6	1.3	-1.9	0.5
Arm fat mass (right)	0.2	0.7	2.9	0.3	-1.7	-0.6	-1.0	-0.2	-0.3
Trunk predicted mass	0.5	3.0	6.5	-1.7	-0.8	-2.5	-2.5	1.2	-0.5
Standing height	0.4	4.1	10.3	-2.9	0.1	-3.2	-2.2	0.3	0.6
Length of working week for main job	0.6	0.7	2.3	-0.5	0.8	-0.6	-0.6	1.5	0.0
Exposure to tobacco smoke at home	3.6	4.1	7.3	-2.1	-2.2	-2.1	-2.7	-0.1	-1.8
Breastfed as a baby	0.5	0.6	1.1	-0.8	-0.4	-0.8	-0.9	1.0	-0.2
Tense / ‘highly strung’	0.2	0.3	0.7	-0.9	-0.4	-0.5	-0.6	-0.2	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.7	-0.7	-0.7	-0.4	-0.5	-1.3	-0.5
Hair/balding pattern: Pattern 4	1.7	4.1	15.3	-0.5	3.9	-0.1	0.5	2.1	2.1
Birth weight of first child	0.7	1.3	2.3	-0.9	0.1	-1.4	-1.5	1.5	-0.6
Peak expiratory flow (PEF)	0.6	1.3	3.0	-1.3	-0.7	-1.6	-1.7	-0.3	0.1
Pulse wave reflection index	0.6	0.7	2.9	0.3	0.3	-0.0	-1.0	0.2	-1.7
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.5	-1.2	0.6	-1.0	-1.0	0.1	0.2
Loud music exposure frequency	1.5	1.7	3.2	1.8	-1.4	1.6	0.9	-0.3	-1.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.9	0.5	1.7	0.6	0.3	0.3	0.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.4	-0.1	0.1	-0.0	0.0	-0.6
Blood clot in the leg (DVT)	0.6	0.8	2.1	-1.1	-1.5	-0.6	0.1	-0.9	0.4
Medication: Paracetamol	0.5	0.8	1.3	-1.1	-0.8	-1.0	-0.8	-0.8	0.3
Headache pain in last month	0.6	1.1	2.1	-1.5	-1.0	-1.1	-1.0	-1.0	-0.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.4	-1.2	0.9	-1.4	-0.7	-1.5	0.7
Glaucoma (self-reported)	0.4	0.4	0.7	0.8	-0.4	0.8	0.5	-0.8	-0.4
Gout (self-reported)	0.4	0.5	1.7	0.8	-1.3	0.5	-0.1	0.0	-0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	3.4	-0.3	1.8	-0.0	-0.0	-0.4	-0.4
Medication: Amlodipine	0.7	0.9	2.9	0.4	-1.7	0.3	0.5	-1.5	-0.2
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.1	0.3	0.2	0.2	1.0	-1.8	1.3
Birth weight	1.7	3.6	6.4	-1.6	-1.5	-1.8	-2.5	2.1	-1.8
Chronic bronchitis/emphysema (mother)	2.2	2.5	5.7	2.4	-0.3	2.1	2.1	-0.4	0.5
High blood pressure (siblings)	0.6	0.8	1.2	1.1	-1.0	1.1	0.6	-0.8	-0.7
Forced vital capacity (FVC), Best measure	0.6	2.4	5.7	-2.0	-0.7	-2.4	-2.0	0.5	0.0
Body fat percentage	0.1	0.4	1.7	0.3	-1.3	-0.2	-0.4	-0.7	0.3
Leg fat percentage (right)	0.3	1.0	2.6	1.1	-1.4	0.6	0.1	-1.6	-0.3
Arm fat-free mass (right)	0.4	1.9	4.6	-1.4	-0.4	-2.1	-2.1	0.5	-0.1
Exposure to tobacco smoke outside home	0.9	1.2	2.3	-1.5	-0.5	-1.4	-0.9	0.7	1.3
Comparative body size at age 10	0.6	1.6	3.4	-0.7	-0.2	-1.1	-1.7	1.8	-1.3
Number of full brothers	0.7	0.9	4.2	-0.5	-2.1	-0.2	-0.7	-0.4	-0.4
Worry too long after embarrassment	0.4	0.6	1.5	0.2	1.2	0.5	0.5	1.1	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	6.5	-2.6	-0.8	-2.0	-1.4	0.1	0.2
Wheeze or whistling in the chest in last year	0.3	0.6	2.0	0.7	0.6	0.4	0.8	-1.4	0.1
Number of children fathered	0.6	0.7	1.7	-1.3	-0.1	-1.2	-1.1	0.3	0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.2	1.1	-0.3	1.5	1.4	-1.5	-0.3
Age at first live birth	1.5	2.7	5.1	-1.5	0.3	-1.7	-2.1	2.3	-1.3
Pulse wave peak to peak time	0.2	0.3	0.4	0.5	-0.5	0.6	0.6	0.3	0.5
Health satisfaction	0.5	0.7	1.2	1.1	-0.0	0.8	1.0	-1.1	0.1
Shortness of breath walking on level ground	0.5	0.6	1.8	0.4	-1.4	0.0	0.2	-1.2	-0.1
Qualifications: College or University degree	0.2	0.8	1.5	-1.2	0.3	-0.7	-1.1	1.2	-0.2
Eye problems/disorders: None of the above	1.1	1.3	2.5	-1.2	-0.4	-1.3	-0.9	1.6	1.1
Mouth/teeth dental problems: Loose teeth	1.2	1.5	3.8	0.8	-1.2	0.9	0.4	-2.0	-1.4
Emphysema/chronic bronchitis	0.8	0.9	2.1	0.5	0.4	0.7	1.2	-0.8	1.4
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	0.5	0.7	0.4	0.6	-0.2	-0.1
Neck or shoulder pain in last month	0.8	1.2	4.1	1.0	-0.9	0.6	-0.7	-0.6	-2.0
Medication: Blood pressure	1.3	2.3	4.7	2.0	-1.3	2.2	1.7	-0.2	-0.6
Angina (self-reported)	0.9	1.1	4.0	0.5	0.5	0.6	-0.5	2.0	-1.3
Migraine (self-reported)	0.4	0.5	2.1	0.2	-0.7	0.4	0.6	-0.2	1.4
Medication: Ibuprofen	0.8	1.0	2.0	-1.4	-0.7	-1.3	-1.2	0.1	-0.0
Medication: Allopurinol	0.4	0.6	1.5	0.2	-1.2	-0.2	-0.7	0.6	-1.0
Medication: Omeprazole	0.5	0.6	1.7	0.0	-1.0	-0.1	-0.8	-0.3	-1.3
Medication: Seretide 50 evohaler	0.2	0.3	0.7	-0.2	0.0	-0.5	0.1	-0.8	0.9
Mean time to correctly identify matches	0.9	1.8	3.7	-1.3	-1.9	-1.2	-1.5	-0.2	-1.3
Heart disease (mother)	0.1	0.1	0.3	0.2	-0.4	0.5	-0.1	-0.3	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	1.1	-0.1	0.4	0.0	0.1	-1.0	-0.1
Whole body fat mass	0.2	0.8	2.4	-0.3	-1.6	-0.9	-1.1	-0.3	0.1
Leg fat mass (right)	0.2	0.8	2.7	0.3	-1.6	-0.4	-0.8	-1.0	-0.3
Arm predicted mass (right)	0.4	2.0	4.8	-1.5	-0.4	-2.2	-2.1	0.7	0.1
Pulse rate, automated reading	0.5	1.6	3.1	-1.3	-0.3	-1.8	-0.4	-1.5	1.4
Alcohol intake frequency.	0.3	0.6	1.9	-0.3	1.4	-0.1	0.4	-1.2	0.4
Comparative height size at age 10	0.4	2.1	3.7	-1.9	1.8	-1.8	-0.3	0.1	1.6
Number of full sisters	3.0	3.6	6.2	2.0	2.3	2.5	2.3	-0.9	0.2
Suffer from ‘nerves’	0.5	0.8	2.4	0.3	1.3	0.6	0.7	-1.6	-0.1
Overall health rating	0.3	0.6	2.3	0.3	1.0	-0.3	-0.4	1.5	0.3
Chest pain or discomfort	1.2	1.8	6.5	1.2	-1.2	0.7	-0.4	-0.7	-2.5
Had major operations	0.3	0.4	1.4	0.8	1.2	0.5	0.4	0.2	0.3
Age at last live birth	2.5	3.6	5.4	-2.1	1.5	-2.1	-2.3	2.2	-0.4
Family relationship satisfaction	0.3	0.3	0.9	0.6	0.7	0.1	0.5	0.1	0.9
Leg pain on walking	0.6	0.8	1.7	-0.9	0.3	-1.3	-1.1	0.9	-0.2
Qualifications: NVQ or HND or HNC or equivalent	3.1	3.7	10.8	0.8	-3.3	0.7	0.1	-2.9	-1.4
Commuting to job workplace: Car/motor vehicle	3.1	3.5	6.6	-2.4	1.1	-2.3	-1.0	1.2	2.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.1	-0.2	0.1	0.1	0.3	0.8	1.1
Medication: Aspirin	0.8	1.1	2.4	0.8	-0.2	1.0	-0.1	1.5	-1.5
Supplements: Vitamin C	0.8	1.0	2.5	0.2	1.6	0.4	1.2	-1.1	0.8
Knee pain experienced in last month	0.3	0.4	0.7	0.7	0.5	-0.3	-0.8	0.6	-0.8
Hypertension (Self-reported)	1.9	5.4	9.1	3.0	-2.0	2.7	2.3	-2.3	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.3	0.4	1.5	0.7	0.9	-0.1	1.0
Illnesses of father: Heart disease	1.7	2.3	6.3	1.6	0.4	1.4	0.2	2.5	-1.7
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.5	0.4	0.0	-0.2	-0.4	-0.2
Smoking status: Previous	0.6	0.8	1.7	-1.0	-1.1	-0.9	-0.3	-0.4	1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	9.5	-2.7	0.3	-3.1	-2.6	0.2	-0.5
Whole body fat-free mass	0.6	3.2	7.0	-1.8	-0.9	-2.6	-2.6	1.1	-0.4
Leg fat-free mass (right)	0.8	4.4	9.3	-2.3	-1.2	-3.0	-3.0	1.3	-0.3
Arm fat percentage (left)	0.2	0.7	3.1	0.7	-1.8	0.1	-0.4	-0.6	-0.1
Average weekly red wine intake	0.8	1.2	3.8	0.1	-1.3	-0.4	-1.1	0.3	-2.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.9	-0.5	0.4	-0.4	-0.4	1.7	0.3
Mood swings	0.1	0.2	0.9	-0.4	1.0	0.2	-0.0	-0.3	-0.3
Loneliness, isolation	0.1	0.1	0.3	0.2	-0.5	-0.2	-0.4	-0.1	-0.2
Long-standing illness, disability or infirmity	0.6	0.9	4.2	0.4	0.0	0.5	0.7	-2.1	-0.5
Ever had bowel cancer screening	0.2	0.3	1.1	-0.1	1.1	0.2	-0.1	-0.3	-0.6
Diabetes diagnosed by doctor	0.5	0.7	1.6	-0.8	-0.8	-1.0	-1.3	0.8	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	5.5	-2.3	-0.0	-2.0	-1.9	0.0	-0.0
Friendships satisfaction	0.2	0.2	0.9	0.4	0.4	-0.1	0.3	-0.9	0.2
Qualifications: nursing, teaching	0.3	0.4	0.9	-0.5	0.8	-0.5	-0.4	0.9	0.6
Commuting to job workplace: Walk	0.2	0.2	1.1	0.1	0.3	0.1	-0.3	0.1	-1.1
Eye problems/disorders: Cataract	0.5	0.6	1.3	0.7	-0.6	1.0	1.2	-0.5	0.5
Mouth/teeth dental problems: Mouth ulcers	2.1	3.3	6.0	-2.1	-1.8	-2.2	-2.5	0.7	-0.8
Medication for cholesterol	0.8	1.2	2.6	-1.6	0.2	-1.6	-1.3	-0.5	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	4.6	0.1	-1.5	-0.2	-1.0	-1.1	-2.1
Back pain experienced in last month	0.3	0.4	1.3	-0.5	0.4	-0.5	-0.8	0.0	-1.1
Mineral and other dietary supplements	0.6	0.9	1.9	0.7	-1.4	1.0	1.0	-0.9	-0.1
Breast cancer (self-reported)	2.1	2.6	6.1	1.8	0.3	1.7	1.6	-2.5	-0.6
Asthma (self-reported)	1.3	2.6	5.9	1.0	1.7	0.8	1.8	-2.4	1.4
Osteoporosis (self-reported)	0.6	0.8	2.3	0.6	0.9	0.4	-0.5	0.9	-1.5
Osteoarthritis (self-reported)	1.1	1.4	3.9	-1.5	-0.1	-2.0	-1.5	-0.2	-0.2
Medication: Aspirin	0.9	1.2	3.1	0.5	-0.0	0.8	-0.4	1.7	-1.8
Medication: Gliclazide	2.6	2.9	5.8	-2.4	0.8	-2.3	-1.7	1.3	1.1
Illnesses of father: None of the above (group 1)	0.4	0.5	2.9	0.0	-0.0	0.1	0.1	-1.7	0.3
Smoking status: Current	0.3	0.4	1.6	0.6	0.1	0.5	0.5	1.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.3	-0.1	-0.4	-0.3	-0.5	0.2	-0.1
Whole body water mass	0.6	3.5	7.6	-1.9	-1.0	-2.8	-2.7	1.2	-0.5
Leg predicted mass (right)	0.8	4.5	9.3	-2.3	-1.3	-3.1	-3.0	1.3	-0.3
Arm fat mass (left)	0.2	0.7	2.5	0.1	-1.6	-0.6	-1.0	-0.2	-0.1
Number of self-reported non-cancer illnesses	0.2	0.4	1.0	0.3	0.5	0.7	0.7	-1.0	-0.2
Average weekly champagne plus white wine intake	0.8	1.1	3.1	1.1	-0.6	0.9	0.1	1.8	-0.9
Miserableness	0.1	0.2	0.5	0.3	0.7	0.7	0.3	-0.1	0.4
Guilty feelings	0.1	0.2	0.6	0.4	-0.8	0.4	0.3	0.3	0.5
Wears glasses or contact lenses	0.2	0.2	0.6	0.3	-0.2	0.3	-0.0	0.8	-0.8
Ever taken oral contraceptive pill	0.4	0.4	1.0	0.6	0.3	0.7	0.8	-0.1	1.0
Hearing aid user	0.3	0.4	1.4	-0.0	0.2	0.1	0.5	-1.2	0.6
Mother’s age at death	0.4	0.5	2.1	-0.3	-1.4	-0.1	-0.3	-0.6	0.2
Financial situation satisfaction	0.1	0.2	0.3	-0.3	-0.6	-0.5	-0.4	-0.1	0.5
Tinnitus: Yes, now most or all of the time	0.8	1.0	1.9	0.9	0.7	1.0	1.4	-0.5	1.1
Commuting to job workplace: Public transport	0.8	0.9	4.2	0.6	2.0	0.1	0.5	-0.9	0.3
Eye problems/disorders: Glaucoma	1.1	1.3	2.9	0.8	-1.3	0.9	0.3	-1.7	-1.4
Medication: Blood pressure	1.3	2.5	3.9	1.9	-1.5	1.8	1.4	-2.0	-0.4
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.2	-1.1	-0.1	-1.4	-1.5	1.5	-0.1
Supplements: Fish oil (including cod liver oil)	1.1	1.5	3.0	-1.3	0.7	-1.3	-1.2	1.7	0.8
High cholesterol (Self-reported)	2.9	5.1	11.6	2.1	-0.4	2.8	0.9	3.4	-2.3
Medication: Bendroflumethiazide	1.0	1.5	2.8	1.7	-1.0	1.7	1.5	0.6	-0.4
Medication: Paracetamol	0.3	0.5	1.8	-0.8	-0.0	-0.7	-0.1	0.2	1.3
Medication: Lisinopril	0.3	0.4	1.3	0.2	-0.8	-0.3	-0.6	0.0	-1.1
Medication: Atorvastatin	3.2	3.9	6.0	2.0	1.1	2.5	2.4	2.4	1.0
Illnesses of father: High blood pressure	0.5	0.7	1.5	0.8	0.0	0.8	1.1	-1.2	-0.3
Alcohol drinker status: Never	0.4	0.5	1.7	0.4	-0.7	0.1	-0.0	-1.3	-0.6
Ever smoked	0.4	0.7	2.5	-0.6	-1.6	-0.6	-0.6	-0.6	0.1
Basal metabolic rate	0.5	3.0	6.5	-1.7	-1.2	-2.6	-2.5	0.9	-0.3
Leg fat percentage (left)	0.1	0.5	1.5	0.5	-1.2	0.1	-0.2	-1.1	0.1
Arm fat-free mass (left)	0.6	2.8	6.5	-1.8	-0.8	-2.5	-2.4	1.0	0.1
Number of operations (self-reported)	0.2	0.3	0.8	-0.7	-0.1	-0.7	-0.9	0.3	-0.4
Average weekly beer plus cider intake	1.1	1.6	4.5	1.0	-0.7	1.4	0.9	-2.1	-0.7
Irritability	0.3	0.5	1.2	-0.3	0.1	-0.2	-0.6	-1.1	-1.1
Risk taking	2.0	2.9	4.8	-1.9	-1.3	-1.9	-2.2	0.2	-1.8
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.4	1.2	-1.2	1.2	0.6	-0.1	-0.5
Fractured/broken bones in last 5 years	0.3	0.4	1.0	-0.3	0.5	-0.7	-0.5	-1.0	-0.6
Age started oral contraceptive pill	1.3	1.6	4.0	2.0	0.5	1.3	0.8	-0.8	-1.6
Diastolic blood pressure, automated reading	1.9	5.7	10.0	3.0	-0.3	2.6	2.9	-3.2	0.5
Ever depressed for a whole week	0.5	0.6	1.7	-0.3	0.1	0.0	0.7	-1.3	1.1
Unable to work because of sickness or disability	1.4	1.8	2.9	1.7	0.1	1.7	1.4	-1.6	-0.5
Commuting to job workplace: Cycle	1.2	1.5	7.6	0.2	-0.7	0.2	-0.9	-0.0	-2.8
Myopia	0.4	0.6	1.7	-0.7	1.3	-0.1	-0.3	-1.0	-0.7
Vascular/heart problems diagnosed by doctor	2.2	5.9	11.2	-3.4	1.6	-3.3	-2.6	1.8	1.0
Cholesterol lowering medication	1.2	1.7	3.7	1.3	-0.3	1.6	0.6	1.9	-1.4
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	4.3	0.1	-1.4	-0.2	-1.3	0.1	-2.1
Pain experienced in last month	0.4	0.7	1.8	-0.6	0.7	-0.3	0.5	1.1	1.3
Supplements: Calcium	0.6	0.7	2.0	0.8	0.4	0.7	0.2	-0.7	-1.4
Basal cell carcinoma (self-reported)	1.3	1.5	3.2	1.1	1.8	1.7	1.4	-0.3	-0.2
Heart attack/myocardial infarction (self-reported)	1.2	1.5	3.2	1.3	1.0	1.5	0.9	1.8	0.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.4	-0.9	-1.5	-0.6	0.1	-0.9	0.6
Heart disease (siblings)	0.7	0.9	3.7	0.3	-1.9	0.9	0.2	-0.3	-0.9
Alcohol drinker status: Previous	0.5	0.6	1.7	-1.3	0.3	-1.0	-0.5	0.5	0.4
Pack years of smoking	0.3	0.5	2.2	0.2	0.5	0.5	0.3	1.5	-0.2
Impedance of whole body	0.4	2.0	5.2	0.0	1.0	0.8	1.7	-2.3	1.4
Leg fat mass (left)	0.2	0.8	2.7	-0.1	-1.6	-0.7	-1.1	-0.8	-0.2
Arm predicted mass (left)	0.6	2.9	6.7	-1.7	-0.5	-2.6	-2.4	1.2	0.1