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chr19:48,464,978-50,108,983

Best TWAS P=3.32e-15 · Best GWAS P=2.07e-15 conditioned to 0.0787

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SPHK2	0.08	0.02	blup	467	0.03	3.6e-04	0.77	-5.3	1.3e-07	-0.54	0.23	0.36	FALSE
2	GTEx	Adrenal Gland	RASIP1	0.20	0.11	lasso	4	0.10	2.4e-04	-5.76	6.2	7.2e-10	0.84	0.03	0.93	FALSE
3	GTEx	Cells Transformed fibroblasts	RASIP1	0.19	0.14	lasso	6	0.20	6.1e-15	7.13	7.9	3.3e-15	0.92	0.04	0.96	TRUE
4	GTEx	Esophagus Mucosa	RASIP1	0.13	0.13	lasso	4	0.13	9.0e-09	-6.74	7.3	3.0e-13	0.92	0.03	0.97	FALSE
5	GTEx	Esophagus Muscularis	NTN5	0.14	0.00	enet	12	0.01	6.5e-02	-6.00	5.5	5.0e-08	0.57	0.02	0.77	FALSE
6	GTEx	Heart Atrial Appendage	MAMSTR	0.24	0.13	lasso	2	0.13	1.3e-06	-5.34	6.3	3.0e-10	0.82	0.02	0.97	FALSE
7	GTEx	Heart Atrial Appendage	NUCB1-AS1	0.16	0.04	lasso	3	0.07	5.3e-04	-6.00	-5.2	1.7e-07	-0.49	0.07	0.21	FALSE
8	GTEx	Heart Left Ventricle	MAMSTR	0.26	0.18	lasso	6	0.21	3.4e-11	-6.02	7.3	2.9e-13	0.92	0.01	0.99	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	RASIP1	0.15	0.04	lasso	6	0.08	2.9e-05	7.94	5.6	2.8e-08	0.87	0.01	0.99	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	NTN5	0.19	0.07	lasso	5	0.08	2.5e-05	6.71	7.4	1.2e-13	0.89	0.06	0.94	FALSE
11	GTEx	Skin Sun Exposed Lower leg	RASIP1	0.21	0.13	enet	19	0.17	1.1e-13	-6.78	6.9	3.9e-12	0.92	0.01	0.99	FALSE
12	GTEx	Skin Sun Exposed Lower leg	NTN5	0.11	0.09	enet	18	0.05	6.2e-05	7.13	7.5	7.9e-14	0.82	0.04	0.96	FALSE
13	GTEx	Testis	RASIP1	0.29	0.20	lasso	8	0.30	7.5e-14	-6.38	7.6	3.9e-14	0.96	0.02	0.98	FALSE
14	GTEx	Testis	NTN5	0.16	0.02	enet	23	0.06	9.6e-04	6.62	5.2	1.5e-07	0.56	0.04	0.63	FALSE
15	METSIM	Adipose	FUT1	0.04	0.01	lasso	6	0.02	6.9e-04	-4.72	-5.5	4.8e-08	-0.69	0.11	0.73	FALSE
16	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FUT2	0.05	0.01	blup	52	0.01	6.1e-02	7.89	-7.5	6.7e-14	-0.94	0.00	0.86	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	FUT2	0.03	0.05	blup	54	0.05	1.9e-10	7.13	-6.9	4.9e-12	-0.84	0.35	0.65	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	NTN5	0.02	0.01	enet	11	0.01	7.6e-04	6.64	6.8	7.6e-12	0.68	0.01	0.91	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	RASIP1	0.02	0.02	blup	56	0.03	3.8e-07	6.33	7.4	1.3e-13	0.92	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FUT2	0.10	0.02	blup	55	0.06	6.8e-04	6.64	-7.0	1.9e-12	-0.83	0.18	0.72	FALSE
21	The Cancer Genome Atlas	Colon Adenocarcinoma	FUT2	0.18	0.22	enet	12	0.18	6.8e-11	6.71	-6.8	8.3e-12	-0.81	0.87	0.13	FALSE
22	The Cancer Genome Atlas	Colon Adenocarcinoma	SEC1	0.05	0.04	enet	11	0.01	8.5e-02	6.67	-6.8	8.2e-12	-0.73	0.02	0.82	FALSE
23	The Cancer Genome Atlas	Esophageal Carcinoma	FUT2	0.33	0.27	lasso	3	0.24	3.9e-08	-6.00	-6.2	6.4e-10	-0.67	0.63	0.34	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FUT2	0.11	0.22	blup	52	0.22	6.3e-24	7.11	-7.1	1.4e-12	-0.86	0.58	0.42	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RASIP1	0.04	0.01	enet	10	0.02	2.3e-03	-5.34	6.2	7.8e-10	0.64	0.11	0.70	FALSE
26	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FUT2	0.10	0.01	blup	51	0.05	9.8e-04	6.68	-7.2	4.3e-13	-0.82	0.03	0.82	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	FUT2	0.02	0.04	lasso	1	0.03	1.8e-04	-5.34	-5.3	9.2e-08	-0.70	0.07	0.60	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAMSTR	0.04	0.04	blup	47	0.06	3.9e-07	-5.76	6.7	2.5e-11	0.83	0.23	0.77	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	NTN5	0.05	0.04	lasso	2	0.02	6.7e-04	6.33	6.3	2.4e-10	0.82	0.01	0.98	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	FUT2	0.09	0.12	blup	52	0.12	4.2e-14	6.64	-7.2	5.7e-13	-0.85	0.63	0.37	FALSE
31	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FUT2	0.05	0.08	lasso	2	0.08	6.7e-09	6.68	-6.7	1.6e-11	-0.79	0.80	0.20	FALSE
32	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FUT2	0.06	0.00	blup	53	0.05	3.5e-04	7.89	-7.2	6.3e-13	-0.86	0.01	0.92	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FUT2	0.08	0.12	lasso	4	0.11	2.5e-05	7.13	-7.1	9.7e-13	-0.78	0.07	0.83	FALSE
34	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	IZUMO1	0.16	0.17	lasso	7	0.15	1.4e-06	-6.74	6.9	5.1e-12	0.86	0.30	0.67	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	FUT2	0.05	0.06	blup	52	0.06	8.6e-07	7.11	-7.7	1.9e-14	-0.91	0.04	0.96	FALSE
36	The Cancer Genome Atlas	Rectum Adenocarcinoma	FUT2	0.26	0.28	lasso	10	0.22	5.2e-06	6.33	-6.8	1.3e-11	-0.86	0.09	0.85	FALSE
37	The Cancer Genome Atlas	Soft Tissue Sarcoma	RASIP1	0.05	0.06	blup	54	0.04	1.4e-03	-6.00	6.5	1.2e-10	0.77	0.05	0.41	FALSE
38	The Cancer Genome Atlas	Stomach Adenocarcinoma	FUT2	0.14	0.16	lasso	8	0.14	4.9e-10	7.13	-7.0	1.9e-12	-0.80	0.63	0.37	FALSE
39	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FUT2	0.22	0.09	lasso	8	0.13	3.0e-05	-3.63	-6.3	2.1e-10	-0.71	0.10	0.86	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	FUT2	0.06	0.04	blup	54	0.06	1.1e-06	-6.00	-7.2	6.5e-13	-0.88	0.03	0.96	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	NTN5	0.11	0.07	blup	43	0.09	2.6e-09	6.64	6.5	6.8e-11	0.75	0.05	0.95	FALSE