Best TWAS P=1.18e-11 · Best GWAS P=2.4e-18 conditioned to 1e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | STAU1 | 0.08 | 0.03 | lasso | 6 | 0.02 | 2.3e-02 | -5.0 | -5.4 | 7.0e-08 | 0.24 | 0.34 | 0.02 | FALSE |
| 2 | GTEx | Colon Sigmoid | CSE1L | 0.18 | 0.12 | lasso | 11 | 0.09 | 4.4e-04 | -5.2 | 5.2 | 2.5e-07 | -0.21 | 0.66 | 0.04 | FALSE |
| 3 | GTEx | Muscle Skeletal | PREX1 | 0.14 | 0.09 | enet | 23 | 0.13 | 2.5e-12 | -5.4 | -6.8 | 1.2e-11 | 0.64 | 0.72 | 0.28 | TRUE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | ZFAS1 | 0.16 | 0.04 | enet | 19 | 0.07 | 1.0e-04 | -3.0 | -5.5 | 3.7e-08 | 0.30 | 0.43 | 0.05 | FALSE |
| 5 | GTEx | Testis | ARFGEF2 | 0.20 | 0.20 | lasso | 7 | 0.24 | 5.4e-11 | -5.0 | 5.4 | 6.4e-08 | -0.28 | 1.00 | 0.00 | FALSE |
| 6 | METSIM | Adipose | ARFGEF2 | 0.04 | 0.03 | lasso | 12 | 0.02 | 9.8e-05 | -5.8 | 5.4 | 8.7e-08 | -0.30 | 0.87 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ARFGEF2 | 0.05 | 0.04 | lasso | 5 | 0.05 | 3.2e-06 | -5.1 | 5.2 | 2.6e-07 | -0.28 | 0.02 | 0.98 | FALSE |