Best TWAS P=6.05e-12 · Best GWAS P=7.03e-12 conditioned to 2.97e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | PPP3R1 | 0.25 | 0.22 | lasso | 4 | 0.26 | 5.4e-20 | 5.6 | 6.9 | 6.1e-12 | -0.03 | 0.03 | 0.97 | TRUE |
| 2 | GTEx | Artery Tibial | RP11-474G23.2 | 0.17 | 0.14 | lasso | 3 | 0.12 | 2.3e-09 | 5.6 | 6.7 | 2.3e-11 | -0.03 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Nerve Tibial | GFPT1 | 0.13 | 0.01 | lasso | 4 | 0.02 | 1.8e-02 | -4.6 | 5.2 | 1.6e-07 | -0.05 | 0.03 | 0.79 | TRUE |
| 4 | YFS | Blood | PPP3R1 | 0.24 | 0.32 | enet | 44 | 0.34 | 9.1e-116 | -6.0 | 6.6 | 3.0e-11 | -0.06 | 0.01 | 0.99 | FALSE |
| 5 | YFS | Blood | WDR92 | 0.05 | 0.05 | lasso | 14 | 0.04 | 1.5e-13 | -5.6 | -5.6 | 2.7e-08 | 0.06 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Esophageal Carcinoma | PNO1 | 0.08 | 0.07 | enet | 4 | 0.08 | 2.0e-03 | -5.1 | -5.5 | 3.4e-08 | 0.06 | 0.02 | 0.77 | FALSE |