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chr1:15,119,708-16,844,848

Best TWAS P=4.37e-21 · Best GWAS P=1.24e-15 conditioned to 0.00695

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HSPB7	0.18	0.16	lasso	11	0.15	3.1e-18	-5.6	-6.0	1.6e-09	-0.05	1.00	0.00	FALSE
2	GTEx	Adrenal Gland	RP11-169K16.9	0.15	-0.01	enet	17	0.04	2.0e-02	-1.1	7.0	3.0e-12	-0.37	0.06	0.44	FALSE
3	GTEx	Brain Cerebellar Hemisphere	PLEKHM2	0.27	0.17	lasso	8	0.16	5.7e-05	-7.9	-7.9	3.2e-15	0.96	0.04	0.94	FALSE
4	GTEx	Brain Cerebellar Hemisphere	RP11-288I21.1	0.24	0.09	lasso	9	0.10	1.7e-03	-6.6	-6.7	2.0e-11	0.83	0.04	0.84	FALSE
5	GTEx	Brain Cerebellum	PLEKHM2	0.26	0.22	lasso	9	0.25	4.8e-08	-7.8	-7.6	3.4e-14	0.90	0.04	0.96	FALSE
6	GTEx	Brain Cerebellum	RP11-288I21.1	0.27	0.14	lasso	16	0.13	1.1e-04	-7.9	-7.8	5.8e-15	0.97	0.03	0.95	FALSE
7	GTEx	Esophagus Mucosa	PLEKHM2	0.10	0.01	enet	20	0.02	1.2e-02	-7.8	8.7	4.1e-18	-0.61	0.04	0.91	FALSE
8	GTEx	Muscle Skeletal	RP11-288I21.1	0.07	0.01	enet	21	0.01	8.1e-02	3.4	-5.5	2.8e-08	0.46	0.08	0.44	FALSE
9	GTEx	Nerve Tibial	EPHA2	0.19	0.13	enet	29	0.14	6.7e-10	-5.0	5.6	2.6e-08	0.02	1.00	0.00	FALSE
10	GTEx	Pituitary	SLC25A34	0.26	0.09	lasso	6	0.11	1.1e-03	-4.1	6.1	8.2e-10	-0.60	0.11	0.48	FALSE
11	GTEx	Skin Not Sun Exposed Suprapubic	RP11-169K16.9	0.19	0.06	lasso	8	0.06	4.7e-04	-4.5	6.2	6.7e-10	-0.02	0.59	0.08	FALSE
12	GTEx	Testis	CASP9	0.21	0.15	lasso	9	0.14	1.1e-06	-6.6	6.6	3.4e-11	-0.79	0.76	0.20	FALSE
13	GTEx	Thyroid	EPHA2	0.10	0.05	lasso	9	0.06	1.7e-05	-4.9	5.8	6.0e-09	-0.02	0.85	0.01	FALSE
14	GTEx	Thyroid	HSPB7	0.17	0.12	lasso	6	0.15	9.8e-12	-5.6	-5.7	1.1e-08	-0.04	1.00	0.00	FALSE
15	METSIM	Adipose	PLEKHM2	0.06	0.06	lasso	6	0.06	6.3e-10	3.3	-5.2	1.9e-07	0.72	0.40	0.60	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	SPEN	0.04	0.02	lasso	3	0.02	1.2e-03	-5.5	-5.3	1.2e-07	-0.05	0.31	0.02	TRUE
17	ROSMAP	Brain Pre-frontal Cortex	PLEKHM2	0.06	0.01	blup	488	0.03	4.7e-05	-3.4	-9.4	4.4e-21	0.66	0.05	0.85	TRUE
18	ROSMAP	Brain Pre-frontal Cortex	HSPB7	0.18	0.18	lasso	9	0.20	2.2e-25	-6.2	-6.6	3.1e-11	-0.02	1.00	0.00	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	CLCNKA	0.16	0.18	enet	15	0.21	1.4e-26	4.9	-5.6	2.8e-08	-0.04	1.00	0.00	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	DDI2	0.09	0.02	bslmm	491	0.04	5.9e-06	-6.5	-6.0	1.8e-09	0.73	0.03	0.96	FALSE
21	YFS	Blood	CASP9	0.04	0.04	enet	19	0.04	3.7e-14	-6.6	6.3	2.5e-10	-0.81	0.93	0.07	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	AGMAT	0.01	0.02	enet	7	0.01	1.9e-03	-7.9	7.3	2.1e-13	-0.97	0.01	0.94	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	CASP9	0.08	0.06	blup	52	0.06	2.4e-12	-5.1	5.5	3.8e-08	-0.77	0.21	0.79	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	CLCNKA	0.07	0.03	enet	15	0.05	9.7e-11	-6.3	6.3	3.5e-10	-0.01	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC25A34	0.03	0.01	blup	47	0.02	6.7e-03	-3.9	6.1	1.0e-09	-0.63	0.06	0.45	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	CLCNKA	0.02	0.02	blup	63	0.01	2.2e-02	4.9	-5.5	3.4e-08	-0.02	0.03	0.75	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	CLCNKA	0.22	0.28	lasso	10	0.28	7.8e-30	-6.2	6.0	1.9e-09	0.03	0.02	0.98	FALSE
28	The Cancer Genome Atlas	Skin Cutaneous Melanoma	SPEN	0.18	0.03	blup	71	0.00	3.7e-01	5.4	-6.0	2.0e-09	-0.05	0.02	0.29	FALSE
29	The Cancer Genome Atlas	Stomach Adenocarcinoma	SPEN	0.05	0.02	enet	11	0.03	2.4e-03	-6.3	-5.5	3.0e-08	-0.10	0.02	0.56	FALSE
30	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CLCNKA	0.21	0.14	blup	63	0.18	5.2e-07	-6.2	-6.2	4.1e-10	-0.02	0.01	0.98	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	HSPB7	0.34	0.42	enet	15	0.46	6.7e-49	-5.3	-5.2	1.8e-07	-0.02	0.53	0.47	FALSE