Hub : Genes

PARP9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1378	0.0565	8.8e-03	0.002	NA	0.000	NA	0.006	2.2e-01	NA	3.1e-01	NA	1.1e-01
2	GTEx	Pituitary	0.3320	0.1130	4.0e-03	-0.012	NA	0.025	NA	-0.010	9.8e-01	NA	7.8e-02	NA	7.0e-01
3	METSIM	Adipose	0.0412	0.0168	1.1e-03	0.002	0.014	0.019	0.015	0.007	1.2e-01	2.5e-03	6.1e-04	2.4e-03	2.3e-02
4	NTR	Blood	0.0202	0.0092	6.3e-03	-0.001	0.003	0.002	0.003	0.001	5.7e-01	2.4e-02	8.4e-02	2.8e-02	1.9e-01
5	YFS	Blood	0.0550	0.0172	2.6e-08	0.016	0.026	0.027	0.027	0.025	3.1e-06	4.6e-09	2.0e-09	3.2e-09	8.3e-09
6	TCGA	Brain Lower Grade Glioma	0.0927	0.0481	3.7e-03	0.036	0.022	0.027	NA	0.044	5.2e-05	1.2e-03	4.0e-04	NA	9.6e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.3	2.0	8.0	2.8	1.8	-0.3	0.8	0.3	0.0
Bipolar Disorder or Schizophrenia	0.6	1.4	3.2	1.7	1.8	0.3	0.8	-1.3	0.0
Depressed Affect (Nagel 2018)	0.3	0.7	1.8	1.1	0.7	0.6	1.4	-0.3	0.1
Depression (Nagel 2018)	1.1	1.7	3.3	1.6	-0.1	1.3	1.4	0.7	1.8
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.0	1.1	-0.4	0.4	-0.9	-1.7	0.7
Neuroticism (Nagel 2018)	0.6	1.4	3.6	0.6	0.8	1.9	1.9	-0.1	0.3
Schizophrenia (2018)	0.4	0.8	3.5	-0.1	0.8	0.5	0.4	-1.9	0.0
Schizophrenia vs Biploar Disorder	0.6	0.8	2.0	-1.3	-1.4	0.2	-0.7	-0.6	0.0
Worry (Nagel 2018)	0.7	1.4	3.5	-1.9	-1.1	1.3	0.2	0.1	-1.5
Alzheimer’s Disease (in mother)	0.2	0.2	0.8	0.6	0.2	-0.4	-0.9	-0.2	0.3
Alzheimer’s Disease (in father)	0.2	0.2	0.6	0.5	0.2	-0.1	0.3	-0.3	0.8
Alzheimer’s Disease (including proxy)	0.2	0.3	0.9	0.2	-0.3	-0.2	-1.0	-0.6	0.3
Crohns Disease (2017)	0.5	1.2	2.6	-1.0	-0.3	-0.8	-1.6	-0.5	1.6
Irritable Bowel Disease (IBD)	0.9	2.1	5.2	1.2	0.7	-0.8	-0.5	-2.2	2.3
Ulcerative Colitis (UC)	2.0	3.8	7.8	2.7	1.4	-0.2	0.8	-2.8	2.3
Major Depression (MDD)	0.4	0.5	1.1	0.9	0.2	0.3	1.1	1.0	0.0
Reaction Time	1.1	2.2	4.8	2.1	-0.3	1.2	1.3	-0.8	2.2
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.9	1.7	1.0	0.6	-0.3	-0.9	0.2
Breast Cancer	0.2	0.4	1.3	-0.5	0.2	0.6	-0.5	0.6	-1.1
Ovarian Cancer	0.2	0.3	1.2	0.0	0.6	0.1	-0.3	-0.1	1.1
Prostate Cancer	0.4	0.6	1.4	-0.6	-0.8	1.1	1.2	0.2	-0.1
Age at First Birth	0.4	0.6	1.9	-0.1	-0.5	-1.4	-1.0	0.4	-0.7
Bipolar Disorder (2011)	1.2	1.1	3.7	1.3	1.2	-0.1	1.9	0.1	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	2.0	0.9	0.6	-0.4	1.2	-1.4	0.1
Coronary Artery Disease (CAD)	0.3	0.3	1.7	0.0	1.3	-0.1	-0.6	0.1	0.3
Crohns Disease (2012)	0.6	1.0	3.2	-0.8	0.4	-1.8	-1.1	0.7	0.0
Mean Putamen Volume	1.3	1.5	3.1	1.5	1.8	-0.0	-1.0	-0.8	1.4
Fasting Glucose	0.3	0.4	1.4	-0.4	1.2	0.3	-0.1	-0.5	-0.7
HbA1C	1.0	1.1	4.1	-0.4	-0.9	2.0	1.2	-0.5	-0.0
HDL Cholesterol	1.4	2.4	6.6	2.6	1.1	0.3	1.4	0.6	2.0
LDL Cholesterol	2.9	4.5	20.2	-0.1	-1.0	-1.8	1.7	4.5	0.0
Lupus	0.4	0.6	1.1	-1.0	-0.6	1.0	0.8	-0.7	0.0
Neuroticism (2016)	3.2	4.6	14.1	1.4	0.7	0.4	3.8	2.6	1.9
Primary Biliary Cirrhosis	0.4	0.5	1.9	-1.1	0.3	0.2	0.1	-1.4	0.0
Rheumatoid Arthritis	0.2	0.3	1.0	1.0	-0.4	0.0	0.5	-0.8	0.0
Schizophrenia (2014)	0.3	0.7	3.7	0.2	0.3	0.1	0.4	-1.9	0.0
Triglycerides	0.5	0.8	2.1	0.4	-1.5	-0.8	0.8	1.1	0.0
Type 2 Diabetes (T2D) (2012)	1.0	1.2	3.8	0.5	2.0	-1.3	-0.9	0.6	0.0
Ulcerative Colitis	1.6	2.4	4.8	2.2	2.1	-0.9	1.4	-1.6	0.0
Blood Eosinophil Count	0.5	3.7	8.6	2.9	0.9	1.5	-0.5	-1.7	2.8
Blood Platelet Count	0.9	10.1	21.4	-3.0	-1.4	-4.6	-1.8	3.2	-3.8
Blood Red Count	0.3	2.5	4.8	-0.3	1.8	-2.2	-1.4	1.9	-1.3
Blood White Count	0.1	0.4	2.0	0.2	-1.4	-0.2	-0.5	-0.4	-0.3
Heel T-Score	0.1	0.8	1.8	-0.5	0.3	-1.1	1.0	1.3	-0.7
BMI	0.5	2.8	5.1	1.6	1.8	2.3	-0.8	-2.0	1.1
Height	0.3	5.6	26.2	1.1	1.2	1.9	-0.1	-5.1	1.0
Waist Hip Ratio (WHR)	0.1	0.6	1.6	1.3	0.7	-0.5	-0.7	0.2	0.8
Systolic Blood Pressure	2.3	11.6	28.6	-5.3	-3.5	-1.7	-0.5	3.3	-3.9
Smoking Status	0.7	1.6	3.6	0.5	0.5	1.5	-1.9	-1.0	1.4
Allergy or Eczema	1.9	5.1	10.6	3.3	0.6	2.5	1.9	-2.6	1.9
Cardiovascular Disease	0.9	2.9	5.5	-1.7	-2.2	0.6	2.3	1.8	-0.8
Hypothyroidism (self reported)	1.4	3.1	6.8	1.6	0.2	2.4	0.5	-1.8	2.6
Respiratory disease	0.7	1.5	3.2	1.3	0.2	1.3	1.8	-1.0	1.1
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.8	-0.5	1.2	-1.3	-0.6	1.4	0.3
Lung FEV1/FVC ratio	1.0	5.1	12.2	1.1	1.0	3.5	1.2	-3.1	2.2
Lung FVC	1.1	5.4	18.1	0.4	1.3	-3.0	-4.3	1.8	-0.1
Neuroticism	0.6	1.4	6.4	0.3	-0.5	1.2	2.5	0.2	0.4
Chronotype (morning person)	0.8	1.7	3.1	-1.6	0.4	-1.3	0.8	1.8	-1.6
Hair Pigment	0.4	10.1	19.3	-2.3	-3.9	-1.5	3.3	4.4	-2.7
Tanning	0.1	1.3	3.9	1.5	2.0	0.3	-0.6	-0.8	0.6
Hand grip strength (left)	0.9	2.5	6.7	-0.8	0.3	-1.6	-2.6	-2.1	0.6
Number of treatments/medications taken	2.5	4.4	14.2	1.7	0.0	1.8	3.8	1.2	2.2
Average weekly spirits intake	2.1	2.6	5.1	2.1	1.6	2.3	0.3	-1.6	0.6
Sensitivity / hurt feelings	2.3	3.9	15.1	1.4	0.0	0.7	3.9	2.0	1.4
Frequency of depressed mood in last 2 weeks	2.0	2.8	9.9	1.9	-0.4	1.1	3.1	0.2	1.5
Hearing difficulty/problems: Yes	1.2	1.9	3.3	-1.3	-1.8	0.1	-1.8	-1.6	-0.6
Relative age of first facial hair	0.2	0.4	1.5	-1.2	-0.5	-0.2	-0.8	0.3	0.0
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	4.2	0.6	-0.3	2.1	0.9	-0.6	1.9
Ever used hormone-replacement therapy (HRT)	1.5	2.0	6.2	-1.0	-0.3	-1.6	-0.8	2.5	-1.2
Ever had hysterectomy (womb removed)	1.7	1.9	7.2	1.2	2.7	0.5	0.6	1.5	0.4
Systolic blood pressure, automated reading	1.7	4.9	13.2	-3.6	-1.5	-1.0	-1.3	2.0	-2.7
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	5.4	0.2	2.3	0.5	-0.8	1.0	0.1
Angina	1.1	1.5	4.1	1.0	0.6	-0.2	1.5	2.0	1.1
Medication for hormone replacement therapy	1.4	1.5	2.8	-1.3	-1.7	-0.7	0.6	1.4	-1.3
Vitamin and mineral supplements	2.3	3.1	6.6	-1.2	-1.7	-2.6	-1.5	1.6	-1.6
Supplements: Zinc	0.5	0.5	1.9	-0.1	-0.7	0.9	-0.1	-1.4	0.4
Medication: Co-codamol	2.2	2.5	5.1	2.3	0.9	1.6	2.1	0.4	1.4
Medication: Metformin	1.2	1.7	5.9	-0.2	1.5	-1.1	-0.7	2.4	-0.5
Diabetes (father)	0.4	0.4	1.0	-0.3	-0.9	0.2	0.6	0.6	1.0
Diabetes (mother)	1.7	2.2	5.9	-2.4	-0.3	-0.9	-1.3	-0.2	-2.2
Severe depression (siblings)	1.5	1.6	5.3	0.9	-1.0	1.2	1.1	-2.3	0.5
Pack years adult smoking proportion	0.7	1.1	3.5	-1.2	-0.1	-0.4	-1.9	0.6	-0.9
Impedance of leg (right)	0.2	1.2	2.8	-0.6	-1.2	-0.8	-1.0	1.7	-0.8
Leg fat-free mass (left)	0.8	4.3	11.5	1.5	2.2	2.1	0.5	-3.4	1.4
Trunk fat percentage	0.2	0.9	2.9	0.8	1.7	0.6	-1.1	-0.4	0.7
Hand grip strength (right)	1.1	3.0	8.8	-0.8	0.8	-0.0	-2.8	-3.0	-0.3
Townsend deprivation index at recruitment	0.3	0.5	1.8	-0.4	-1.4	-0.8	-0.4	-0.1	-0.0
Current tobacco smoking	1.6	2.6	7.7	1.6	0.5	2.0	-0.4	-2.8	0.8
Average weekly fortified wine intake	1.8	2.1	4.1	-2.0	0.8	-0.9	-1.9	0.8	-1.7
Maternal smoking around birth	0.5	0.7	3.1	0.5	-0.1	0.0	-0.9	0.3	1.8
Fed-up feelings	1.0	1.8	5.5	2.3	0.5	1.1	1.6	0.1	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.2	1.4	0.5	1.5	1.2	0.1	1.8
Relative age voice broke	1.3	2.0	5.5	-1.4	-2.3	-0.2	-0.6	-0.3	-2.0
Taking other prescription medications	2.6	4.1	10.3	1.4	-0.8	2.4	3.2	0.0	2.4
Age when periods started (menarche)	0.3	0.7	2.1	-0.2	-1.4	-1.4	-0.0	0.3	0.0
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	6.3	0.7	0.7	0.7	1.7	2.5	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.3	0.1	0.4	-0.6	0.9	1.1	-0.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.9	-0.8	0.9	0.4	-0.7	-1.4	-0.8
Qualifications: CSEs or equivalent	1.0	1.3	4.3	-2.1	-1.5	-0.6	0.5	0.8	-0.4
Serious illness, injury or assault to yourself	0.3	0.4	1.0	0.3	0.3	-0.4	0.9	-0.1	1.0
High blood pressure	1.0	2.7	4.0	-1.9	-2.0	-0.8	1.7	1.8	-1.4
Hayfever, allergic rhinitis or eczema	1.3	2.7	6.2	2.2	0.5	1.2	0.9	-2.5	1.6
Multivitamins +/- minerals	0.8	1.1	2.3	0.7	0.8	1.2	0.9	-1.5	0.8
Stomach or abdominal pain in last month	1.2	1.5	4.3	0.2	-1.2	2.1	1.7	-0.5	-0.3
Supplements: Glucosamine	0.2	0.3	0.8	0.2	0.4	0.2	0.9	0.3	-0.7
Diverticular disease/diverticulitis (self-reported)	2.8	3.3	10.1	1.5	-0.3	2.0	3.2	-0.6	1.8
Medication: Atenolol	0.3	0.3	1.0	0.1	0.3	-0.1	0.8	1.0	-0.4
Medication: Levothyroxine sodium	1.2	2.0	6.2	1.0	0.2	1.7	-0.8	-1.1	2.5
Sitting height	0.3	1.8	4.3	1.3	1.7	1.5	-0.1	-2.1	0.3
Chronic bronchitis/emphysema (father)	1.7	2.0	4.8	-0.1	1.8	-2.2	-1.9	0.3	-0.0
High blood pressure (mother)	0.8	1.1	3.1	-0.6	-1.2	1.8	1.1	-0.6	-0.1
Body mass index (BMI)	0.5	1.9	3.0	1.2	1.7	1.5	-0.6	-1.4	1.7
Impedance of leg (left)	0.3	1.4	3.8	-0.7	-1.1	-0.8	-1.1	1.9	-1.1
Leg predicted mass (left)	0.8	4.5	12.1	1.6	2.1	2.2	0.6	-3.5	1.5
Trunk fat mass	0.3	1.4	3.2	1.2	1.8	1.1	-0.9	-1.1	0.8
Waist circumference	0.8	2.9	4.6	2.1	2.1	1.6	-0.5	-1.5	2.0
Number of incorrect matches in round	0.7	1.2	5.4	-0.5	-2.3	-0.1	0.9	-0.3	-0.7
Past tobacco smoking	1.0	1.7	3.4	-1.0	-1.9	-0.5	1.8	0.5	-1.6
Alcohol usually taken with meals	0.5	0.8	2.4	-0.8	0.6	0.2	0.2	-1.1	1.6
Nervous feelings	1.4	2.6	4.3	-1.6	-1.6	-1.7	1.0	2.1	-1.5
Frequency of tenseness / restlessness in last 2 weeks	3.2	4.9	12.3	3.0	1.0	2.1	3.5	0.1	1.5
Hearing difficulty/problems with background noise	0.7	1.2	2.7	0.9	-0.0	1.1	0.0	-1.6	1.5
Hair/balding pattern: Pattern 2	0.2	0.3	0.5	-0.4	0.2	0.6	0.6	-0.3	-0.7
Had menopause	0.8	1.0	2.1	-1.3	-0.7	-1.5	-1.0	0.7	0.4
Had other major operations	1.2	1.5	5.7	-1.1	-2.4	-0.3	0.6	-0.2	1.2
Forced vital capacity (FVC)	0.3	1.0	3.6	0.1	0.2	-0.5	-1.9	-1.5	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.3	0.8	0.3	-0.0	1.5	1.2	0.8
Ever unenthusiastic/disinterested for a whole week	3.5	4.3	12.9	3.6	3.1	0.1	0.0	0.1	1.7
Qualifications: None of the above	1.2	2.6	7.5	1.9	1.2	0.2	1.8	2.7	0.4
Financial difficulties in last 2 years	0.7	1.0	3.2	-0.9	-0.6	-1.8	-1.1	-0.2	-0.5
Mouth/teeth dental problems	1.2	1.9	5.1	-1.9	-2.3	-0.2	0.7	-0.1	-1.4
Heart attack	0.8	1.0	1.8	0.5	1.2	-1.3	1.2	1.0	-0.2
Allergy	1.1	2.6	7.3	-1.9	-0.5	-1.4	-0.8	2.7	-1.4
Pain all over the body in last month	1.3	1.4	2.8	1.1	-1.5	0.8	0.1	-1.7	1.0
Diabetes (self-reported)	0.9	1.4	5.7	0.4	1.1	-1.0	0.2	2.4	0.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.3	0.1	-0.6	1.0	1.8	-1.1	-1.0
Medication: Ramipril	2.2	2.8	6.0	0.5	-1.9	-1.2	2.4	2.3	0.4
Medication: Simvastatin	1.3	1.9	9.4	-0.3	0.6	-1.0	0.5	3.1	-0.5
Fluid intelligence score	0.4	0.7	1.7	0.5	-0.9	1.0	0.7	-1.3	0.5
Illnesses of siblings	0.3	0.4	1.3	0.2	-0.4	1.1	0.4	-0.5	-0.8
Neuroticism score	0.6	1.3	7.2	0.4	0.0	0.3	2.7	0.7	0.2
Weight	0.7	3.6	7.1	1.5	2.2	2.2	-0.5	-2.7	1.5
Impedance of arm (right)	0.2	0.9	2.2	-0.8	-1.5	-0.4	1.4	0.8	-0.2
Arm fat percentage (right)	0.2	1.0	2.0	1.0	1.2	0.8	-0.4	-0.7	1.4
Trunk fat-free mass	0.6	3.6	11.5	1.6	1.8	1.8	-0.3	-3.4	1.0
Hip circumference	1.4	5.9	7.9	2.7	2.7	2.8	0.9	-2.1	2.8
Time employed in main current job	1.1	1.3	3.2	0.7	1.6	0.9	-1.8	-0.4	0.7
Alcohol intake versus 10 years previously	1.1	1.7	4.0	-1.4	-1.6	1.1	0.1	-2.0	0.4
Father’s age at death	0.3	0.4	1.2	-0.5	-0.1	1.0	0.3	-1.1	0.4
Worrier / anxious feelings	0.3	0.6	1.4	-0.6	0.5	0.7	1.1	1.2	0.2
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	5.8	2.0	0.5	2.4	1.9	-1.1	2.4
Falls in the last year	2.9	3.9	11.3	2.0	1.0	2.3	0.9	-3.4	1.0
Hair/balding pattern: Pattern 3	1.3	2.0	4.5	-1.3	-2.1	-0.7	1.2	1.3	-1.5
Number of live births	1.2	1.7	6.1	-0.5	-0.2	-0.9	1.5	2.5	-0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	4.3	0.3	0.1	1.1	-0.7	-2.1	0.7
Pulse rate	1.0	1.7	4.9	-0.8	0.3	2.2	0.6	-1.9	0.7
Happiness	1.0	1.2	3.6	0.8	1.9	1.4	0.8	-0.4	0.0
Noisy workplace	0.1	0.1	0.4	0.6	0.2	0.4	-0.1	0.4	-0.3
Qualifications: A levels/AS levels or equivalent	0.8	1.8	5.0	-2.2	-1.9	1.1	0.3	-1.1	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.4	-0.6	-0.5	1.1	-0.4	-1.2	-0.1
Mouth/teeth dental problems: Dentures	1.8	3.0	8.9	3.0	2.7	0.9	-0.4	0.6	0.7
Asthma	0.1	0.2	0.9	0.2	0.5	0.2	-0.2	-0.9	-0.1
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	5.6	0.6	0.9	-1.0	2.4	1.3	-0.1
Medication: Cholesterol lowering	2.5	3.9	17.6	-0.2	-0.7	-0.9	2.1	4.2	-0.3
Depression (self-reported)	2.3	2.7	6.9	2.6	-0.3	0.6	2.3	0.3	2.0
Medication: Lansoprazole	0.3	0.3	1.0	0.1	0.1	0.6	-0.5	-0.6	1.0
Prospective memory result	1.1	1.3	7.1	0.1	0.0	0.2	-2.7	-0.7	-0.5
Lung cancer (father)	1.0	1.1	2.7	-0.8	-0.4	-1.6	-1.5	-0.6	-0.9
Illnesses of mother	0.6	0.7	2.1	0.2	1.2	-1.4	-0.1	0.1	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	4.3	0.4	0.7	0.8	-1.2	-2.1	0.1
Pulse wave Arterial Stiffness index	0.9	1.0	2.3	-1.3	-0.7	0.3	-1.2	-0.3	-1.5
Impedance of arm (left)	0.3	1.3	1.7	-1.1	-1.3	-1.0	1.0	1.0	-1.3
Arm fat mass (right)	0.4	1.8	2.6	1.2	1.6	1.4	-0.6	-1.6	1.6
Trunk predicted mass	0.6	3.5	11.5	1.6	1.7	1.8	-0.1	-3.4	1.0
Standing height	0.2	2.5	10.1	0.8	1.4	1.4	0.0	-3.2	-0.2
Length of working week for main job	0.5	0.5	1.5	-0.6	1.2	0.7	0.8	-0.3	0.4
Exposure to tobacco smoke at home	0.2	0.2	0.9	-0.3	-0.1	0.2	-0.3	-0.5	-0.9
Breastfed as a baby	0.3	0.4	0.9	0.6	-0.1	0.3	0.5	1.0	0.8
Tense / ‘highly strung’	0.1	0.2	0.5	-0.7	-0.1	0.1	0.5	0.2	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	6.4	2.5	-0.8	-0.6	2.3	0.2	2.2
Hair/balding pattern: Pattern 4	0.6	1.4	3.1	-1.8	-0.9	0.6	1.3	1.2	-0.8
Birth weight of first child	0.4	0.8	2.6	1.4	1.6	0.0	0.3	-0.2	0.4
Peak expiratory flow (PEF)	0.7	1.5	6.1	-0.2	-0.6	1.0	-1.2	-2.5	0.7
Pulse wave reflection index	0.4	0.5	1.2	-0.5	-0.6	-0.5	-0.8	0.3	-1.1
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.7	1.3	0.9	1.2	-0.5	-1.7	1.3
Loud music exposure frequency	1.4	1.5	6.1	-0.2	-1.1	1.0	-0.7	-2.5	0.5
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	6.2	-0.4	-1.2	1.6	0.7	-2.5	-0.0
Mouth/teeth dental problems: Bleeding gums	0.7	0.8	2.4	-0.5	-0.2	0.6	-0.9	-1.5	1.1
Blood clot in the leg (DVT)	0.1	0.2	0.6	-0.3	-0.8	0.1	0.5	-0.3	0.2
Medication: Paracetamol	0.7	1.2	2.9	-1.7	-1.6	-0.8	0.4	0.5	-0.7
Headache pain in last month	0.4	0.7	3.2	0.2	0.4	-0.5	1.8	-0.1	-0.6
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	7.0	0.9	2.1	-0.9	-2.3	-2.6	0.7
Glaucoma (self-reported)	0.5	0.6	1.4	-1.2	-0.2	0.9	0.5	-0.3	-1.0
Gout (self-reported)	0.2	0.3	1.0	-0.6	-1.0	-0.2	-0.4	0.1	-0.5
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	7.0	1.4	0.4	1.9	-0.1	-1.4	2.6
Medication: Amlodipine	1.6	2.3	3.8	-1.8	-1.6	-0.8	-0.1	1.8	-2.0
Medication: Ventolin 100micrograms inhaler	0.7	0.8	2.6	0.6	0.9	0.3	-0.1	-1.6	1.1
Birth weight	0.6	1.3	5.5	-0.7	-0.8	-1.1	0.1	-0.3	-2.3
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.1	0.3	1.0	0.3	-0.6	0.2	0.9
High blood pressure (siblings)	0.4	0.5	1.6	-0.6	-0.0	-1.1	-1.3	-0.3	-0.3
Forced vital capacity (FVC), Best measure	0.5	1.8	6.2	0.4	1.3	-0.5	-2.5	-1.5	-0.3
Body fat percentage	0.3	1.1	2.4	1.0	1.6	1.1	-0.9	-0.5	1.0
Leg fat percentage (right)	0.4	1.6	4.1	1.6	1.3	1.0	-0.7	0.3	2.0
Arm fat-free mass (right)	0.8	4.2	12.1	1.5	2.0	2.3	-0.6	-3.5	1.1
Exposure to tobacco smoke outside home	0.6	0.8	1.2	-1.1	-0.7	1.0	0.9	-0.1	-1.1
Comparative body size at age 10	0.4	1.0	2.2	-1.5	-0.2	-1.5	-1.1	0.2	-0.1
Number of full brothers	0.1	0.1	0.2	0.4	-0.3	0.4	0.5	-0.3	-0.1
Worry too long after embarrassment	0.8	1.3	3.9	1.4	2.0	0.7	0.2	-0.4	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	1.6	1.2	-0.9	-0.6	1.1	-1.3	1.2
Wheeze or whistling in the chest in last year	0.7	1.2	2.7	0.1	1.6	1.6	0.3	-1.5	-0.1
Number of children fathered	0.8	0.9	2.3	-0.4	-1.5	0.9	1.3	-0.6	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.8	3.6	-1.7	0.2	-1.9	-1.0	0.4	-1.8
Age at first live birth	0.7	1.3	4.4	-0.5	0.6	0.0	-2.1	-1.6	-0.4
Pulse wave peak to peak time	0.8	0.9	2.0	1.3	0.7	-0.1	1.1	-0.2	1.4
Health satisfaction	0.6	0.7	2.0	0.9	0.3	1.4	0.8	0.6	0.6
Shortness of breath walking on level ground	0.8	1.0	3.2	-0.2	-1.0	1.0	-0.7	-1.8	-0.2
Qualifications: College or University degree	0.4	1.1	2.8	-1.0	-0.9	1.1	-0.6	-1.7	-0.6
Eye problems/disorders: None of the above	0.7	0.8	1.5	-1.2	-0.6	-1.1	-0.3	-1.2	-0.4
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.5	0.7	1.4	-0.4	-0.6	1.6	0.8
Emphysema/chronic bronchitis	0.3	0.3	1.0	0.6	0.1	-1.0	-0.4	-0.7	0.4
Medication for pain relief, constipation, heartburn	0.6	1.1	3.6	-0.0	-0.5	0.8	-1.3	-1.9	-0.6
Neck or shoulder pain in last month	0.7	1.0	5.6	0.5	-0.1	0.3	2.4	-0.2	0.3
Medication: Blood pressure	0.9	1.6	4.0	-1.1	-1.6	1.0	1.0	2.0	-0.6
Angina (self-reported)	1.3	1.8	5.1	1.2	1.3	-0.3	1.1	2.3	1.0
Migraine (self-reported)	0.9	1.1	2.4	0.9	1.5	-0.5	0.5	1.6	0.9
Medication: Ibuprofen	1.7	2.0	5.8	1.0	0.6	-1.5	2.4	1.5	0.3
Medication: Allopurinol	0.1	0.1	0.3	0.3	0.1	0.1	0.6	0.2	0.2
Medication: Omeprazole	0.6	0.8	1.6	0.7	0.5	1.3	0.9	1.2	0.3
Medication: Seretide 50 evohaler	1.0	1.2	3.8	0.7	-1.3	2.0	0.7	-0.5	0.6
Mean time to correctly identify matches	1.0	1.9	4.4	2.1	0.2	-0.0	1.7	-0.0	2.1
Heart disease (mother)	0.6	0.7	1.8	-1.4	-0.7	0.3	-1.1	-0.5	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.2	-0.9	-0.3	-0.7	-0.3	0.3	-1.8
Whole body fat mass	0.4	1.8	3.6	1.2	1.9	1.3	-1.1	-1.3	1.1
Leg fat mass (right)	0.6	2.2	3.6	1.6	1.9	1.6	-0.6	-0.9	1.7
Arm predicted mass (right)	0.7	3.4	9.4	1.4	2.1	1.8	-0.8	-3.1	1.0
Pulse rate, automated reading	1.3	4.4	16.1	-4.0	-1.9	1.1	1.9	-0.1	-1.2
Alcohol intake frequency.	0.1	0.3	0.7	-0.8	-0.1	-0.4	0.6	-0.1	-0.5
Comparative height size at age 10	1.1	6.0	14.4	2.6	2.4	3.0	-0.3	-3.8	0.6
Number of full sisters	0.6	0.7	3.3	0.6	-0.5	0.1	1.8	0.4	0.1
Suffer from ‘nerves’	0.4	0.6	1.7	-0.8	0.3	-1.3	-0.8	0.5	-0.3
Overall health rating	1.0	2.2	5.4	0.2	-2.1	2.3	1.7	-0.2	0.7
Chest pain or discomfort	0.5	0.7	1.8	0.5	0.1	1.4	1.3	-0.1	-0.7
Had major operations	0.6	0.7	2.5	-0.8	-1.6	-0.4	0.3	0.6	-0.8
Age at last live birth	0.7	1.0	1.9	-1.4	-0.4	-0.7	-1.2	-0.4	-1.2
Family relationship satisfaction	0.4	0.5	1.1	-0.2	1.0	0.8	0.8	0.1	-0.6
Leg pain on walking	0.5	0.6	1.3	1.0	0.5	1.1	0.5	-0.8	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.0	0.2	1.0	0.6	0.3	-0.4	0.3
Commuting to job workplace: Car/motor vehicle	1.7	2.0	5.1	2.3	0.6	2.0	0.2	0.2	1.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.4	0.1	1.1	0.0	0.2	1.2	-0.0
Medication: Aspirin	1.0	1.3	3.8	0.4	0.9	-1.4	1.1	2.0	-0.2
Supplements: Vitamin C	0.9	1.1	2.2	0.1	1.5	1.5	-0.3	-1.4	0.1
Knee pain experienced in last month	0.5	0.8	4.3	0.2	-0.4	0.3	2.1	0.5	0.3
Hypertension (Self-reported)	1.3	3.7	5.7	-2.2	-2.4	-0.7	2.1	2.2	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.3	0.1	-0.3	1.5	1.0	-1.3	0.7
Illnesses of father: Heart disease	0.9	1.2	3.6	1.6	0.7	0.5	0.6	-0.4	1.9
Illnesses of siblings: Diabetes	0.6	0.7	3.6	0.2	0.2	-0.5	0.4	0.4	1.9
Smoking status: Previous	1.2	1.8	5.6	0.2	1.4	-1.0	-2.4	1.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	4.7	0.3	-0.1	1.9	2.2	-2.0	1.0
Whole body fat-free mass	0.8	4.5	13.2	1.7	2.1	2.1	-0.1	-3.6	1.3
Leg fat-free mass (right)	0.8	4.4	12.1	1.5	2.2	2.3	0.6	-3.5	1.3
Arm fat percentage (left)	0.2	0.8	1.9	0.9	1.4	0.7	-0.5	-0.7	0.9
Average weekly red wine intake	0.4	0.6	1.1	0.9	1.0	-0.8	0.4	-0.1	1.0
Handedness (chirality/laterality): Left-handed	1.3	1.5	7.8	0.0	-0.8	-0.3	2.8	0.4	0.7
Mood swings	0.7	1.2	4.4	1.5	-0.1	0.4	2.1	0.0	0.5
Loneliness, isolation	0.6	0.8	2.9	-1.7	-0.4	-0.7	-0.1	-0.3	-1.1
Long-standing illness, disability or infirmity	1.3	2.0	5.9	1.6	-0.8	0.8	1.3	-1.1	2.4
Ever had bowel cancer screening	0.6	0.7	1.3	-0.9	-1.1	0.8	0.3	-1.2	-0.7
Diabetes diagnosed by doctor	0.7	1.2	5.2	0.1	0.6	-1.0	0.3	2.3	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.0	-0.3	0.1	-0.2	1.0	-0.7	-0.6
Friendships satisfaction	0.7	0.8	3.2	-0.4	1.0	1.8	0.5	0.3	0.6
Qualifications: nursing, teaching	0.9	1.3	3.5	-1.5	-0.5	0.6	-1.3	-1.9	-0.1
Commuting to job workplace: Walk	2.4	2.6	7.4	-1.5	-2.7	-0.9	1.1	-0.5	-1.9
Eye problems/disorders: Cataract	0.7	0.8	2.4	0.7	0.3	-0.3	-1.3	1.6	0.3
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.0	-1.3	-1.6	-2.0	-0.3	0.9	-0.4
Medication for cholesterol	0.5	0.8	2.7	0.4	0.5	-0.1	-1.6	-1.3	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	-0.7	-0.6	0.5	-0.1	0.4	-0.0
Back pain experienced in last month	1.2	1.8	3.0	1.5	1.4	1.1	1.5	-0.1	1.7
Mineral and other dietary supplements	1.4	1.8	4.0	-1.3	-1.9	-2.0	-0.5	0.7	-1.0
Breast cancer (self-reported)	0.7	0.8	2.9	-1.2	-1.7	0.4	0.0	0.0	-0.4
Asthma (self-reported)	0.1	0.3	1.0	0.5	0.5	0.2	-0.1	-1.0	0.0
Osteoporosis (self-reported)	0.7	0.8	1.9	0.2	-0.7	1.2	0.4	-1.4	0.9
Osteoarthritis (self-reported)	0.8	1.0	3.2	-0.0	1.1	1.8	0.8	0.4	-1.0
Medication: Aspirin	1.1	1.4	4.4	0.7	0.8	-1.0	1.4	2.1	-0.1
Medication: Gliclazide	0.5	0.6	2.5	0.6	1.6	0.2	-0.6	0.4	-0.2
Illnesses of father: None of the above (group 1)	0.6	0.8	2.3	-1.1	-0.4	-0.3	-0.8	0.5	-1.5
Smoking status: Current	1.9	3.0	9.5	1.4	0.5	2.2	-0.5	-3.1	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	6.7	-0.2	1.1	-2.6	-1.4	-0.1	-0.4
Whole body water mass	0.8	4.5	12.9	1.7	2.1	2.1	-0.1	-3.6	1.3
Leg predicted mass (right)	0.8	4.1	11.6	1.4	2.2	2.1	0.5	-3.4	1.2
Arm fat mass (left)	0.4	1.7	2.9	1.0	1.7	1.3	-0.8	-1.6	1.1
Number of self-reported non-cancer illnesses	1.7	2.9	9.4	1.3	-0.1	1.2	3.1	-0.1	2.2
Average weekly champagne plus white wine intake	0.2	0.2	0.5	-0.5	0.1	-0.7	-0.3	0.2	-0.5
Miserableness	2.0	3.5	10.5	2.6	0.8	1.0	3.2	-0.5	1.3
Guilty feelings	0.2	0.4	0.9	-0.3	0.9	0.5	0.9	-0.2	0.3
Wears glasses or contact lenses	1.8	2.1	5.7	2.3	0.7	0.3	0.9	-0.5	2.4
Ever taken oral contraceptive pill	1.4	1.6	3.6	1.3	-0.2	1.5	1.2	-1.9	0.5
Hearing aid user	3.6	4.0	9.9	1.2	0.1	3.1	2.1	-2.8	0.9
Mother’s age at death	1.5	1.9	3.4	-1.7	0.8	-1.9	-1.4	0.7	-1.4
Financial situation satisfaction	0.7	0.9	2.6	-0.1	0.4	1.1	-0.8	-1.6	-1.0
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.7	1.6	1.0	1.9	0.5	-0.2	0.2
Commuting to job workplace: Public transport	0.9	1.1	4.4	-0.1	-1.2	-0.3	0.5	-2.1	0.6
Eye problems/disorders: Glaucoma	1.3	1.5	3.9	-0.8	-1.6	1.1	2.0	-0.1	-1.0
Medication: Blood pressure	0.7	1.3	3.0	-1.7	-1.0	-0.5	1.3	0.7	-1.1
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.5	0.3	1.6	1.4	-0.4	-1.6	0.7
Supplements: Fish oil (including cod liver oil)	0.9	1.1	3.4	0.9	0.9	1.9	0.7	-1.1	0.1
High cholesterol (Self-reported)	1.4	2.5	11.5	-0.7	-0.5	-1.2	0.7	3.4	-0.9
Medication: Bendroflumethiazide	1.9	2.9	8.5	-0.8	-2.3	0.6	2.9	0.8	-1.5
Medication: Paracetamol	0.1	0.2	0.7	-0.6	-0.5	-0.3	0.1	0.2	0.8
Medication: Lisinopril	0.2	0.3	0.6	0.6	-0.0	0.4	0.7	0.8	0.4
Medication: Atorvastatin	1.2	1.5	4.5	0.2	0.4	-2.0	0.4	2.1	0.5
Illnesses of father: High blood pressure	1.5	1.9	3.6	-1.5	-0.6	-1.9	-1.9	0.8	-1.0
Alcohol drinker status: Never	0.9	1.1	3.8	-0.7	-0.8	-1.9	-0.3	0.7	-1.0
Ever smoked	0.8	1.3	3.1	1.1	1.0	1.0	-0.7	-1.1	1.8
Basal metabolic rate	0.8	4.4	12.0	1.6	2.2	2.2	-0.2	-3.5	1.3
Leg fat percentage (left)	0.4	1.4	3.4	1.4	1.3	0.9	-0.8	0.5	1.9
Arm fat-free mass (left)	1.0	5.0	12.0	1.8	2.2	2.5	-0.5	-3.5	1.7
Number of operations (self-reported)	0.5	0.8	3.3	-0.4	-1.8	-0.5	0.3	0.6	-0.7
Average weekly beer plus cider intake	0.4	0.6	1.0	0.8	-0.3	1.0	-0.9	0.6	-0.8
Irritability	0.4	0.6	1.8	0.5	1.3	0.8	0.9	0.2	0.6
Risk taking	1.2	1.7	3.1	1.2	1.8	-1.6	-1.0	-0.4	1.4
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.5	0.1	1.2	-0.3	-0.3	-1.2	-0.0
Fractured/broken bones in last 5 years	0.1	0.1	0.4	0.1	-0.3	-0.1	0.2	-0.7	0.4
Age started oral contraceptive pill	0.6	0.8	1.6	-0.5	-1.1	0.4	-1.3	0.8	-0.8
Diastolic blood pressure, automated reading	2.5	7.8	24.3	-4.9	-3.3	-0.9	0.1	1.4	-3.0
Ever depressed for a whole week	1.2	1.5	2.9	1.4	1.6	-0.0	0.9	-1.7	0.8
Unable to work because of sickness or disability	2.6	3.4	8.3	0.2	-2.9	1.6	2.1	-1.0	1.9
Commuting to job workplace: Cycle	1.5	1.8	5.5	-1.1	0.4	0.0	-1.8	-2.3	-1.0
Myopia	0.8	1.2	2.7	-1.7	-0.3	-1.6	-1.0	0.2	-0.8
Vascular/heart problems diagnosed by doctor	1.0	2.8	4.0	1.7	2.0	0.9	-1.9	-1.9	1.2
Cholesterol lowering medication	0.6	0.9	3.2	0.6	0.8	-0.8	0.6	1.8	0.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.2	-0.0	0.4	1.5	0.7	0.1	0.2
Pain experienced in last month	2.0	3.3	7.6	-2.0	-0.4	-1.7	-2.8	-0.5	-2.3
Supplements: Calcium	3.1	3.4	6.7	1.3	1.7	2.5	-0.7	-2.6	1.6
Basal cell carcinoma (self-reported)	6.7	8.0	17.2	-4.1	-1.6	-1.9	-2.2	1.7	-4.1
Heart attack/myocardial infarction (self-reported)	1.0	1.2	2.3	0.7	1.0	-1.4	1.5	1.3	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.5	-0.5	-0.7	0.3	0.1	-0.4	0.2
Heart disease (siblings)	1.4	1.7	3.7	1.6	1.9	-0.9	-0.4	1.7	0.6
Alcohol drinker status: Previous	0.5	0.5	1.3	0.7	1.1	0.6	0.4	-0.7	0.6
Pack years of smoking	1.1	1.6	4.9	-1.1	-0.0	-1.0	-2.2	1.1	-1.1
Impedance of whole body	0.3	1.4	2.9	-1.1	-1.7	-0.9	0.1	1.4	-1.2
Leg fat mass (left)	0.5	1.9	3.5	1.5	1.9	1.6	-0.6	-0.9	1.5
Arm predicted mass (left)	1.0	5.1	12.6	1.9	2.0	2.5	-0.4	-3.5	2.0