TWAS hub - RYK

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.125	0.0360	2.3e-05	0.053	0.019	0.040	0.044	0.035	4.6e-07	0.0021	1.2e-05	4.6e-06	4.0e-05
2	GTEx	Adipose Subcutaneous	0.075	0.0330	7.8e-03	-0.002	NA	-0.003	NA	0.000	4.7e-01	NA	8.2e-01	NA	3.1e-01
3	GTEx	Esophagus Mucosa	0.083	0.0340	5.9e-03	0.080	NA	0.053	NA	0.031	4.9e-06	NA	1.8e-04	NA	3.6e-03
4	GTEx	Nerve Tibial	0.154	0.0434	2.3e-05	0.131	NA	0.080	NA	0.106	1.5e-09	NA	2.6e-06	NA	5.9e-08
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.092	0.0650	3.9e-03	0.010	0.014	-0.004	NA	0.002	8.6e-02	0.0480	6.5e-01	NA	2.3e-01
6	TCGA	Thyroid Carcinoma	0.033	0.0190	5.6e-03	0.012	0.012	0.011	NA	0.009	2.4e-02	0.0200	2.5e-02	NA	3.9e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Systolic Blood Pressure	6.0	30.1	75.3	0.1	0.8	-8.7	-8.5	-5.6	-0.9
Impedance of arm (left)	5.2	24.1	42.5	0.2	-6.5	-5.0	-0.9	-6.0	-6.3
Impedance of arm (right)	5.0	23.3	42.8	0.5	-6.5	-4.6	-0.6	-5.9	-6.4
Impedance of whole body	4.3	22.0	37.9	0.6	-6.2	-4.9	-1.2	-5.9	-5.8
Health satisfaction	4.1	5.3	10.1	1.9	-3.2	-0.7	1.2	-2.8	-2.9
Vascular/heart problems diagnosed by doctor	4.0	10.9	29.8	2.2	-0.0	5.5	4.4	3.3	0.1
High blood pressure	3.6	10.2	26.6	-1.7	-0.5	-5.2	-4.3	-3.5	-0.3
Hypertension (Self-reported)	3.4	9.6	24.8	-1.5	-0.4	-5.0	-4.0	-3.7	-0.6
Mean Putamen Volume	3.3	3.8	8.0	0.0	0.0	-2.8	-1.4	-2.8	-2.2
Comparative height size at age 10	3.3	17.9	31.4	1.2	-5.5	-4.3	-1.2	-5.6	-4.9
Cardiovascular Disease	3.2	10.6	28.0	0.3	1.4	-5.3	-4.9	-3.1	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.1	3.7	10.5	-1.0	3.2	1.6	0.8	2.1	1.8
Diastolic blood pressure, automated reading	3.1	9.5	27.2	-1.7	1.8	-4.4	-5.2	-1.6	1.2
Impedance of leg (left)	3.0	14.7	29.2	0.7	-5.4	-3.8	-0.8	-4.8	-4.6
Forced expiratory volume in 1-second (FEV1), predicted	2.9	6.1	14.4	1.6	-2.4	-2.1	0.5	-3.0	-3.8
Height	2.8	54.0	112.4	0.1	-7.5	-10.6	-6.5	-8.3	-6.5
Impedance of leg (right)	2.8	13.5	24.9	-0.0	-5.0	-4.1	-1.4	-4.5	-4.2
Heel bone mineral density (BMD) T-score, automated (right)	2.8	6.4	13.1	0.3	2.4	3.1	1.6	3.6	2.7
Medication: Atenolol	2.7	3.4	8.5	-0.8	0.3	-2.9	-2.5	-2.2	-0.3
Ever had bowel cancer screening	2.7	3.2	6.3	0.3	-2.5	-0.3	1.4	-2.1	-2.5
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.8	4.4	2.0	-2.1	2.0	2.1	-0.4	-0.7
Pain type(s) experienced in last month: Hip pain	2.7	3.4	10.0	0.1	-0.9	2.7	3.2	1.4	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	8.0	-1.7	2.8	-0.1	-0.9	1.8	2.4
Coronary Artery Disease (CAD)	2.5	3.0	7.3	-1.2	2.1	-2.7	-2.1	-0.4	0.6
Lung FVC	2.5	12.8	51.0	-1.4	7.1	0.5	-1.9	2.8	3.5
Stomach or abdominal pain in last month	2.5	3.1	9.8	0.4	-3.1	-1.4	-0.8	-2.1	-1.2
Depression (self-reported)	2.5	3.0	8.3	-2.9	-0.0	-2.4	-1.4	-1.3	-0.4
Gout (self-reported)	2.5	3.4	7.9	-0.0	-1.3	0.8	2.8	-1.7	-2.7
Medication: Blood pressure	2.5	4.4	11.6	-1.7	-0.7	-3.4	-2.6	-2.1	-0.0
Supplements: Zinc	2.4	2.7	4.9	1.2	-2.0	0.1	1.2	-2.0	-2.2
Comparative body size at age 10	2.4	6.6	13.8	-0.0	1.7	3.7	2.8	3.2	2.2
Family relationship satisfaction	2.4	2.9	7.1	2.1	-2.7	-1.1	-0.6	-1.8	-1.1
Standing height	2.3	23.0	50.3	0.5	-4.8	-7.1	-4.3	-5.2	-4.3
Eye problems/disorders: None of the above	2.3	2.7	4.8	2.0	-0.7	1.2	2.0	-1.1	-2.2
Migraine (self-reported)	2.3	2.8	6.4	2.5	-1.3	2.2	1.9	0.5	-0.4
Trunk fat percentage	2.2	9.0	24.8	-0.1	-5.0	-1.8	0.9	-3.3	-3.8
Illnesses of father: High blood pressure	2.2	2.7	6.2	0.5	2.5	-1.6	-2.3	0.2	1.4
Alzheimer’s Disease (in father)	2.1	2.3	4.4	-1.0	-2.0	-2.1	-0.7	-1.7	-1.1
Prostate Cancer	2.1	2.9	8.1	-1.1	1.1	-2.9	-2.3	-1.3	-0.3
Systolic blood pressure, automated reading	2.1	6.2	16.8	-0.4	0.1	-3.8	-4.1	-2.4	0.2
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.7	7.8	0.6	2.7	2.8	1.9	2.6	1.6
Medication: Simvastatin	2.0	2.9	5.8	-0.7	-1.3	-2.4	-0.5	-2.4	-1.9
Length of working week for main job	2.0	2.2	6.6	-0.2	0.6	-2.6	-1.9	-1.3	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.1	5.1	-0.5	1.6	0.0	-1.7	1.4	2.3
Medication: Omeprazole	1.9	2.3	9.6	0.3	-3.1	0.9	1.4	-0.6	-1.0
Eye problems/disorders: Glaucoma	1.9	2.2	7.7	-2.8	0.3	-0.4	-1.2	0.9	1.8
Medication: Blood pressure	1.9	3.5	7.7	0.2	-0.2	-2.7	-2.4	-2.8	-0.7
Glaucoma (self-reported)	1.8	2.1	8.3	-2.9	0.8	-0.5	-0.9	0.7	1.4
Medication: Bendroflumethiazide	1.8	2.7	5.8	-1.7	0.6	-2.4	-1.6	-2.1	-0.6
Bipolar Disorder (2011)	1.7	1.7	2.9	-0.7	1.4	1.4	0.4	1.7	1.7
Ever used hormone-replacement therapy (HRT)	1.7	2.1	5.1	-2.2	1.0	-1.7	-1.6	0.1	1.2
Angina	1.7	2.2	5.9	-1.5	1.0	-2.4	-1.6	-1.4	-0.4
Commuting to job workplace: Walk	1.7	1.8	4.5	-0.7	0.6	2.1	1.8	1.4	0.7
Number of full brothers	1.6	2.0	5.1	-1.6	0.6	0.6	0.2	2.3	1.9
Number of self-reported non-cancer illnesses	1.6	2.8	3.7	-1.8	-1.9	-0.1	1.9	-1.6	-1.9
Mother’s age at death	1.6	2.0	4.6	-2.1	-0.6	-0.2	-0.6	1.6	2.0
High blood pressure (mother)	1.5	2.1	4.5	-0.9	0.1	-2.1	-0.9	-1.9	-1.7
Noisy workplace	1.5	1.9	4.8	0.2	-2.2	-1.6	-1.1	-1.3	-0.9
Loud music exposure frequency	1.5	1.7	3.0	1.4	0.9	1.3	-0.2	1.6	1.7
Body fat percentage	1.5	5.9	19.7	-0.3	-4.4	-0.9	1.3	-2.3	-2.8
Mouth/teeth dental problems: Loose teeth	1.5	1.8	4.9	0.4	-2.2	-1.4	-0.2	-1.4	-1.4
Angina (self-reported)	1.5	2.0	4.8	-1.4	1.1	-2.2	-1.4	-1.4	-0.3
Hearing aid user	1.5	1.7	4.5	-1.2	0.6	-2.1	-1.9	-0.4	-0.1
Current tobacco smoking	1.4	2.3	4.1	-0.9	1.5	-1.3	-2.0	1.2	1.9
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	4.0	-0.5	-1.0	1.4	1.1	2.0	1.3
Trunk fat mass	1.4	6.2	16.7	-0.1	-4.1	-1.8	0.5	-2.7	-3.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	4.7	-2.2	0.2	-1.1	-1.5	0.6	2.0
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	6.8	1.5	0.2	2.6	1.3	1.7	0.6
Medication: Amlodipine	1.4	2.0	6.4	-0.1	1.1	-1.4	-2.5	-1.0	1.1
Illnesses of father: None of the above (group 1)	1.4	1.8	4.3	1.0	-2.1	1.0	1.4	0.0	-1.5
HbA1C	1.3	1.4	3.2	0.0	-0.5	-1.4	-1.8	-1.7	-0.7
Had menopause	1.3	1.6	4.6	-2.1	-0.7	1.1	1.7	0.6	0.5
Father’s age at death	1.3	1.7	3.8	-1.6	-0.6	1.2	2.0	1.3	0.4
Pulse wave Arterial Stiffness index	1.3	1.5	3.2	0.3	-0.4	-1.8	-1.0	-1.8	-1.1
Leg pain on walking	1.3	1.6	3.3	1.8	-0.6	0.5	1.4	-1.5	-1.3
Supplements: Vitamin C	1.3	1.5	4.3	0.0	-2.1	-0.8	0.0	-1.5	-1.3
Smoking status: Current	1.3	2.1	3.4	-0.7	1.7	-1.2	-1.8	1.2	1.8
Alcohol drinker status: Never	1.3	1.6	6.0	-1.6	-2.4	0.3	0.8	-0.1	-0.3
Verbal and Numeric Reasoning (VNR)	1.2	2.9	6.4	-2.5	0.6	-1.3	-2.0	1.4	1.7
Fasting Glucose	1.2	1.4	4.1	-1.2	-0.5	0.4	-0.8	1.4	2.0
Rheumatoid Arthritis	1.2	1.6	5.3	0.5	0.1	1.8	2.3	0.2	-0.9
Relative age of first facial hair	1.2	2.5	5.5	0.4	2.4	0.5	-1.0	1.9	2.0
Medication for hormone replacement therapy	1.2	1.3	3.1	-1.4	0.4	0.2	-0.3	1.7	1.8
Serious illness, injury or assault to yourself	1.2	1.4	4.0	-0.6	1.1	-2.0	-1.6	-0.3	0.5
Medication: Ramipril	1.2	1.5	4.1	0.4	0.5	-1.8	-2.0	-1.0	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	7.3	1.0	2.7	0.3	-0.2	0.5	-0.2
Eye problems/disorders: Cataract	1.2	1.4	3.0	-1.3	0.2	-0.8	-1.5	0.9	1.7
Osteoporosis (self-reported)	1.2	1.5	2.8	-0.3	-1.4	1.6	1.7	1.1	0.1
Miserableness	1.2	2.1	7.4	-0.1	0.4	0.4	-1.3	1.7	2.7
Average weekly beer plus cider intake	1.2	1.8	4.2	-1.1	1.1	-1.7	-2.1	-1.1	-0.0
Supplements: Calcium	1.2	1.3	3.2	0.4	-0.3	1.8	1.8	1.0	0.1
Alzheimer’s Disease (in mother)	1.1	1.3	3.5	-0.3	0.5	1.1	0.8	1.9	1.5
Age at First Birth	1.1	1.6	4.2	-0.1	-0.6	-1.6	-2.1	0.3	1.5
Ulcerative Colitis	1.1	1.6	3.0	0.9	-1.3	-1.1	-0.5	-1.6	-1.7
Heel T-Score	1.1	8.7	24.1	-0.7	4.9	1.6	-0.3	3.5	3.6
Hand grip strength (left)	1.1	3.0	6.9	1.7	0.2	-2.6	-2.5	-1.1	-0.8
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.2	1.1	-0.0	-0.5	-1.8	-0.2	1.5
Forced vital capacity (FVC)	1.1	4.3	12.0	0.8	3.5	-1.9	-2.9	0.6	0.7
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	3.7	0.9	-1.9	0.1	1.4	-1.3	-1.6
Medication: Cholesterol lowering	1.1	1.7	5.1	-2.3	0.7	-1.9	-0.2	-0.9	-0.2
Exposure to tobacco smoke at home	1.1	1.2	3.4	0.8	-0.3	-1.8	-1.2	-0.9	-1.0
High blood pressure (siblings)	1.1	1.5	4.7	-2.2	0.1	-1.7	-1.2	0.0	0.4
Shortness of breath walking on level ground	1.1	1.3	3.2	1.1	-1.8	1.3	1.3	0.2	-0.1
Medication: Allopurinol	1.1	1.5	3.0	0.2	-1.1	0.3	1.7	-1.4	-1.7
High cholesterol (Self-reported)	1.1	2.0	5.1	-0.7	-1.3	-2.3	-0.7	-1.8	-1.1
Average weekly spirits intake	1.0	1.2	3.6	-1.1	-0.4	-1.9	-1.0	-1.0	-0.8
Severe depression (siblings)	1.0	1.1	2.4	-1.0	0.7	1.5	0.6	1.2	1.1
Fed-up feelings	1.0	1.8	3.6	0.4	-1.9	-1.8	-1.6	-1.0	-0.0
Qualifications: CSEs or equivalent	1.0	1.3	2.5	-0.2	0.9	1.6	1.2	1.5	0.8
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.5	-0.1	1.1	1.6	1.1	1.3	0.7
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.8	1.0	-0.1	-1.5	-1.7	-1.0	-0.5
Forced vital capacity (FVC), Best measure	1.0	3.6	12.4	0.9	3.5	-1.6	-2.3	0.2	0.2
Smoking status: Previous	1.0	1.4	5.8	2.4	0.1	1.0	1.3	-0.0	-0.2
Supplements: Fish oil (including cod liver oil)	1.0	1.3	6.7	2.6	0.5	0.5	-0.3	-0.6	-0.0
Heart disease (siblings)	1.0	1.3	2.7	1.2	-1.2	1.7	1.1	1.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.2	3.2	-1.0	-0.6	-1.6	-1.8	-0.5	0.1
Lupus	0.9	1.4	4.6	0.4	-2.1	0.4	1.6	0.0	-0.8
Diabetes (mother)	0.9	1.2	4.7	2.2	-0.8	0.8	0.6	-0.1	-0.8
Townsend deprivation index at recruitment	0.9	1.2	2.9	-0.9	-1.5	-0.5	0.2	-1.7	-1.0
Average weekly fortified wine intake	0.9	1.1	3.2	-0.9	1.8	0.3	-0.7	1.2	0.8
Relative age voice broke	0.9	1.3	2.9	1.3	0.4	0.3	-1.2	1.2	1.7
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	3.3	-0.1	-1.8	-0.3	-1.1	0.7	1.1
Fluid intelligence score	0.9	1.9	3.2	-1.7	1.0	-1.2	-1.8	0.7	1.5
Arm fat percentage (right)	0.9	3.7	11.7	-0.1	-3.4	-0.3	1.6	-1.6	-2.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	10.5	1.1	3.2	-1.5	-1.5	-0.5	-0.7
Peak expiratory flow (PEF)	0.9	2.1	3.8	0.4	2.0	-1.7	-0.8	-1.3	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	3.5	0.5	-0.8	0.9	1.9	-0.1	-0.9
Neck or shoulder pain in last month	0.9	1.3	3.0	0.9	-1.2	0.8	-0.2	1.7	1.3
Whole body fat mass	0.9	3.6	12.2	-0.3	-3.5	-1.0	0.7	-1.8	-2.1
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.7	1.6	0.1	0.2	0.8	-0.8	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.4	1.1	-1.6	-1.1	-1.3	-0.2	0.3
Arm fat percentage (left)	0.9	3.6	11.3	-0.2	-3.4	-0.5	1.4	-1.7	-2.3
Average weekly red wine intake	0.9	1.3	2.4	1.3	-1.4	-0.3	0.5	-1.2	-1.6
Breast cancer (self-reported)	0.9	1.1	5.9	0.5	-2.4	-0.2	-0.2	-0.5	-0.2
Guilty feelings	0.9	1.4	3.8	-0.7	-0.4	-1.7	-2.0	0.1	1.1
Cholesterol lowering medication	0.9	1.4	2.7	1.5	-1.3	-0.8	-0.4	-1.6	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	4.6	0.4	-2.1	0.8	0.9	-0.2	-0.4
Bipolar Disorder (2018)	0.8	1.3	5.1	-1.0	2.3	1.0	0.0	0.6	0.4
Intelligence (Savage-Jansen 2018)	0.8	2.6	6.9	-2.6	1.3	-0.8	-1.6	1.1	1.6
Schizophrenia vs Biploar Disorder	0.8	1.1	3.9	0.3	-2.0	0.3	1.1	-0.2	-1.0
Major Depression (MDD)	0.8	0.9	4.0	0.6	-2.0	-0.5	-1.0	0.1	0.1
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.7	-1.6	0.4	-1.2	-0.5	-1.0	-0.2
Smoking Status	0.8	1.9	4.7	1.3	2.2	0.5	-0.1	1.5	1.5
Chronotype (morning person)	0.8	1.9	4.5	-0.5	2.1	-1.6	-0.7	-1.7	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.2	-0.9	-0.7	1.1	1.5	1.1	0.5
Taking other prescription medications	0.8	1.2	2.4	0.3	-1.5	0.5	1.5	-1.2	-1.0
Age when periods started (menarche)	0.8	1.8	5.0	-0.3	2.2	0.2	-0.7	1.6	1.6
Multivitamins +/- minerals	0.8	1.0	1.9	1.0	-0.7	1.4	1.1	-0.7	-1.0
Allergy	0.8	1.9	6.0	0.3	0.9	0.6	-1.0	1.8	2.4
Hair/balding pattern: Pattern 3	0.8	1.2	4.8	-2.2	0.8	0.1	-0.2	0.8	0.9
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	10.0	0.8	3.2	-1.5	-1.8	-0.0	-0.3
Medication: Lansoprazole	0.8	0.9	2.4	-0.3	-1.6	1.2	1.0	0.3	0.4
Exposure to tobacco smoke outside home	0.8	1.1	2.9	1.1	-0.6	0.9	-0.2	1.1	1.7
Pulse wave peak to peak time	0.8	1.0	2.5	-0.5	0.2	1.2	0.6	1.6	1.1
Suffer from ‘nerves’	0.8	1.3	3.0	-1.7	-0.1	0.2	0.1	1.5	1.4
Illnesses of father: Heart disease	0.8	1.1	2.6	0.2	1.1	-1.2	-1.6	-0.7	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	7.5	0.2	2.7	0.4	-0.8	0.7	0.9
Leg fat percentage (left)	0.8	2.8	10.4	-0.3	-3.2	0.4	1.8	-1.0	-1.4
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.5	1.9	0.3	0.5	-0.3	0.8	0.8
Primary Biliary Cirrhosis	0.7	1.0	4.5	0.7	2.1	0.1	-0.9	0.6	0.4
Lung FEV1/FVC ratio	0.7	3.8	8.6	-0.0	-1.4	0.1	2.4	-2.5	-2.9
Ever had hysterectomy (womb removed)	0.7	0.7	2.0	-0.3	-1.4	0.7	0.8	0.3	1.1
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.0	-1.2	-0.4	1.4	1.0	0.3	-0.1
Hand grip strength (right)	0.7	2.0	5.4	0.9	0.2	-2.3	-2.3	-0.5	-0.2
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.9	0.2	1.0	0.2	0.3	1.3	1.4
Hayfever, allergic rhinitis or eczema	0.7	1.6	4.8	0.1	-0.4	0.1	1.4	-1.7	-2.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.1	-0.2	-1.3	1.0	1.8	-0.2	-0.7
Heart attack	0.7	0.9	2.3	-1.0	1.5	-1.2	-0.8	-0.1	0.3
Pain all over the body in last month	0.7	0.8	3.8	0.4	2.0	0.2	0.6	-0.5	-0.4
Diabetes (self-reported)	0.7	1.1	3.2	0.3	0.2	1.8	1.8	0.6	-0.0
Prospective memory result	0.7	0.8	3.2	0.9	-1.8	-0.1	0.6	-0.6	-0.6
Breastfed as a baby	0.7	0.9	2.2	-0.0	-0.6	-1.2	-0.4	-1.5	-1.1
Leg fat percentage (right)	0.7	2.4	9.4	-0.7	-3.1	0.2	1.5	-0.9	-1.3
Number of children fathered	0.7	0.8	1.7	0.5	1.3	-0.6	-1.3	0.7	0.7
Alcohol intake frequency.	0.7	1.6	5.2	-0.3	-0.3	2.3	2.0	0.5	-0.4
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.8	-0.1	-0.6	0.6	1.2	-1.0	-1.4
Mood swings	0.7	1.3	2.6	1.0	-1.2	-1.5	-1.6	-0.4	-0.0
Medication: Lisinopril	0.7	0.9	2.9	-0.1	-0.4	-1.1	-0.8	-1.7	-0.8
Age started oral contraceptive pill	0.7	0.8	1.6	-0.5	0.9	-1.3	-0.9	-0.8	-1.0
Myopia	0.7	0.9	1.8	1.3	0.7	-0.7	-0.7	-1.2	-1.0
Depressed Affect (Nagel 2018)	0.6	1.2	2.8	0.7	-1.7	-0.8	-1.6	0.0	0.7
Depression (Nagel 2018)	0.6	0.9	4.2	0.2	-2.1	0.5	0.9	0.0	-0.2
Breast Cancer	0.6	1.4	2.6	-0.3	-0.9	1.5	0.4	1.6	1.5
Waist Hip Ratio (WHR)	0.6	2.7	6.7	1.1	-2.6	-1.6	-1.1	-1.5	-1.2
Allergy or Eczema	0.6	1.5	3.6	-0.2	-1.0	0.5	1.4	-1.5	-1.9
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.6	0.8	1.1	1.5	1.6	0.7	0.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.8	-0.5	0.1	-0.2	1.2	-1.3	-1.1
Diabetes (father)	0.6	0.8	3.9	-2.0	0.4	0.0	0.7	-0.5	-0.1
Past tobacco smoking	0.6	1.1	4.5	-2.1	-0.8	-0.7	-0.8	-0.5	-0.3
Illnesses of mother	0.6	0.8	2.9	1.7	-1.2	0.3	0.1	0.1	-0.3
Tense / ‘highly strung’	0.6	1.0	3.1	-0.3	-0.6	-1.8	-1.5	-0.4	0.2
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.7	1.2	-1.3	0.4	0.6	-0.6	-0.6
Worry too long after embarrassment	0.6	1.0	2.8	-0.1	0.6	-1.7	-1.5	-0.2	0.6
Medication: Seretide 50 evohaler	0.6	0.7	1.1	-0.8	-0.7	-1.1	-0.5	-1.1	-0.8
Knee pain experienced in last month	0.6	0.9	4.4	-0.4	-2.1	-0.4	-0.6	-0.5	0.2
Friendships satisfaction	0.6	0.7	2.4	1.6	-1.3	0.1	-0.1	0.2	0.4
Medication for cholesterol	0.6	1.0	2.7	0.1	0.8	1.1	1.0	1.6	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.3	-1.1	-1.1	0.5	1.1	-0.2	0.4
Back pain experienced in last month	0.6	0.9	3.3	1.8	-0.6	0.3	0.6	-0.4	-1.1
Mineral and other dietary supplements	0.6	0.8	2.1	-1.4	-0.1	-1.3	-1.1	-0.2	-0.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.7	0.3	1.2	-0.5	-1.3	0.3	0.6
Medication: Atorvastatin	0.6	0.7	1.9	-0.2	1.0	-1.4	-1.0	-0.5	0.3
Irritability	0.6	1.0	2.2	0.4	-1.2	-1.5	-1.3	-0.1	0.8
Fractured/broken bones in last 5 years	0.6	0.7	2.3	-0.8	1.5	0.7	0.3	0.6	0.6
Unable to work because of sickness or disability	0.6	0.8	2.1	-0.6	-0.8	-0.5	0.6	-1.4	-1.1
Basal cell carcinoma (self-reported)	0.6	0.7	2.2	0.1	-0.5	-1.5	-1.1	-0.7	-0.1
Alcohol drinker status: Previous	0.6	0.7	1.2	0.9	-1.1	1.1	0.7	-0.1	-0.5
Pack years of smoking	0.6	0.9	2.7	-0.8	-0.5	-1.2	-1.7	-0.3	0.6
Neuroticism (Nagel 2018)	0.5	1.2	3.1	-0.2	-0.8	-1.0	-1.8	0.6	1.5
HDL Cholesterol	0.5	0.9	2.9	0.0	1.7	0.0	0.2	1.2	0.9
BMI	0.5	3.0	6.3	-0.4	1.0	2.5	1.6	2.2	1.9
Frequency of depressed mood in last 2 weeks	0.5	0.7	3.1	-0.3	-1.8	0.4	1.0	-0.2	-0.2
Vitamin and mineral supplements	0.5	0.6	0.8	-0.3	0.7	-0.9	-0.8	0.9	0.9
Supplements: Glucosamine	0.5	0.6	1.2	0.8	-0.5	0.7	1.1	-0.7	-0.8
Number of incorrect matches in round	0.5	0.9	3.3	-0.1	-1.8	0.7	1.0	0.6	0.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.0	-0.9	-1.0	-0.8	0.3	-0.8	-0.9
Neuroticism score	0.5	1.0	1.7	0.1	-1.0	-1.3	-1.3	0.3	1.2
Lung cancer (father)	0.5	0.6	1.9	1.1	1.4	0.3	-0.4	-0.1	-0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	2.0	0.2	1.0	1.4	0.9	1.0	0.5
Medication: Ibuprofen	0.5	0.6	1.9	0.5	1.4	0.7	0.5	0.7	0.3
Diabetes diagnosed by doctor	0.5	0.8	2.0	0.8	-0.2	1.4	1.4	0.2	-0.4
Qualifications: nursing, teaching	0.5	0.7	1.8	-1.3	0.4	1.0	0.9	0.7	0.4
Ever depressed for a whole week	0.5	0.7	1.6	0.4	-1.3	0.9	1.2	-0.1	-0.3
Pain experienced in last month	0.5	0.8	2.6	-0.5	1.6	-1.0	-0.5	-0.8	-0.4
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.6	-0.8	1.2	-1.1	-0.5	-0.3	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.3	-1.5	0.0	0.3	0.8	0.7	0.5
Irritable Bowel Disease (IBD)	0.4	0.9	2.2	0.2	-1.2	-0.1	-0.1	-1.5	-1.3
Triglycerides	0.4	0.7	1.8	-0.3	0.5	-0.1	-1.2	0.8	1.3
Respiratory disease	0.4	0.8	2.6	0.9	-0.1	0.2	0.7	-0.9	-1.6
Neuroticism	0.4	1.0	2.2	0.2	-1.0	-1.3	-1.5	0.5	1.1
Number of treatments/medications taken	0.4	0.7	2.0	-0.2	-1.4	-0.1	0.4	-1.4	-0.4
Pack years adult smoking proportion	0.4	0.7	2.1	-0.6	-0.4	-1.0	-1.4	-0.2	0.6
Body mass index (BMI)	0.4	1.7	4.3	-0.3	0.2	2.1	1.9	1.2	0.7
Hearing difficulty/problems with background noise	0.4	0.7	2.1	1.4	-1.1	0.4	-0.5	0.4	0.6
Financial difficulties in last 2 years	0.4	0.6	1.3	1.1	-0.9	0.2	-0.8	0.6	0.6
Happiness	0.4	0.5	1.5	1.0	-1.2	0.4	0.5	0.3	0.1
Hair/balding pattern: Pattern 4	0.4	1.0	5.3	2.3	-0.5	-0.5	-0.7	-0.2	0.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.8	-1.0	-0.4	0.0	-0.3	0.6	1.3
Blood clot in the leg (DVT)	0.4	0.5	1.3	-0.9	-0.1	0.7	1.1	0.6	0.3
Headache pain in last month	0.4	0.7	1.5	0.4	-0.9	0.5	1.0	-0.4	-1.2
Medication: Aspirin	0.4	0.6	1.2	-0.2	0.9	-1.0	-0.1	-1.1	-0.7
Asthma (self-reported)	0.4	0.7	2.4	0.3	-0.8	-0.4	0.5	-1.0	-1.5
Medication: Aspirin	0.4	0.6	1.4	0.0	0.9	-0.9	-0.1	-1.2	-0.6
Medication: Gliclazide	0.4	0.5	1.1	-0.6	0.0	-0.4	-0.6	0.9	1.0
Average weekly champagne plus white wine intake	0.4	0.5	1.4	0.6	-0.8	0.6	1.2	-0.0	-0.7
Ever taken oral contraceptive pill	0.4	0.5	1.4	0.4	0.7	-0.4	-0.0	-1.2	-0.8
Commuting to job workplace: Public transport	0.4	0.5	1.5	0.7	-1.2	0.4	0.5	-0.7	-0.2
Leg fat mass (left)	0.4	1.4	6.2	-0.4	-2.5	-0.0	0.9	-0.6	-1.0
Worry (Nagel 2018)	0.3	0.6	1.2	-0.3	-0.8	-0.7	-0.8	0.6	1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	-0.8	-0.8	-0.4	-0.0	0.6	0.8
Crohns Disease (2017)	0.3	0.7	2.9	0.1	-0.5	0.0	0.1	-1.7	-1.1
Ovarian Cancer	0.3	0.4	0.8	-0.2	-0.7	0.9	0.9	0.2	-0.1
Neuroticism (2016)	0.3	0.4	2.1	0.1	-1.5	-0.5	-0.3	-0.2	0.3
Blood White Count	0.3	2.0	4.1	1.3	1.2	-1.4	-1.3	-2.0	-0.8
Sensitivity / hurt feelings	0.3	0.5	1.8	-0.8	-0.1	0.0	-0.1	0.8	1.3
Medication: Metformin	0.3	0.4	1.0	0.1	0.5	1.0	0.9	0.4	-0.1
Medication: Levothyroxine sodium	0.3	0.5	1.3	-0.9	1.1	-0.1	-0.4	0.7	0.4
Sitting height	0.3	2.1	5.7	-0.8	0.8	-2.4	-2.2	-0.6	-0.0
Waist circumference	0.3	0.9	5.4	0.3	-2.3	0.0	0.4	-0.1	-0.3
Nervous feelings	0.3	0.6	1.3	-0.0	-0.1	0.8	0.6	1.1	0.9
Hair/balding pattern: Pattern 2	0.3	0.3	1.0	0.2	-0.0	0.7	0.7	-0.2	-1.0
Qualifications: None of the above	0.3	0.6	1.4	0.3	-1.2	-0.7	-0.6	-0.8	-0.7
Weight	0.3	1.3	3.8	0.0	-1.9	-1.1	-0.0	-1.1	-1.3
Alcohol intake versus 10 years previously	0.3	0.4	1.0	0.1	0.7	-0.6	-1.0	-0.9	-0.0
Worrier / anxious feelings	0.3	0.6	1.8	-0.3	-1.3	-0.2	-0.3	0.5	1.1
Falls in the last year	0.3	0.4	1.0	-0.0	1.0	-0.5	-0.7	-0.7	0.0
Medication: Paracetamol	0.3	0.5	1.9	-0.7	1.4	-0.4	-0.1	-0.5	-0.2
Birth weight	0.3	0.7	1.6	-0.4	-1.3	-0.6	0.6	-1.0	-0.7
Qualifications: College or University degree	0.3	1.0	2.1	-1.3	1.0	0.3	-0.3	1.1	1.5
Emphysema/chronic bronchitis	0.3	0.3	0.6	-0.3	0.4	-0.7	-0.8	-0.4	-0.4
Mean time to correctly identify matches	0.3	0.5	1.3	0.1	-1.0	0.8	1.2	0.6	-0.1
Heart disease (mother)	0.3	0.3	0.6	-0.4	0.5	-0.5	-0.8	-0.8	-0.3
Leg fat mass (right)	0.3	1.3	5.7	-0.6	-2.4	-0.2	0.8	-0.6	-0.9
Arm predicted mass (right)	0.3	1.3	2.5	-0.0	1.4	-0.5	-1.5	1.0	1.6
Number of full sisters	0.3	0.4	1.1	1.1	-0.1	0.6	1.0	-0.0	-0.3
Overall health rating	0.3	0.7	3.0	-0.2	-1.7	0.3	0.9	-0.5	-0.4
Illnesses of siblings: Diabetes	0.3	0.4	1.1	0.5	-0.4	0.4	1.1	-0.4	-0.6
Long-standing illness, disability or infirmity	0.3	0.4	0.7	-0.7	-0.6	0.9	0.8	0.4	0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.6	-1.3	1.0	-0.2	0.3	-0.0	-0.1
Osteoarthritis (self-reported)	0.3	0.4	0.8	0.4	-0.2	-0.9	-0.2	-0.7	-0.8
Arm fat mass (left)	0.3	1.3	4.3	-0.3	-2.1	-0.7	0.5	-1.1	-1.3
Ever smoked	0.3	0.6	2.7	1.6	0.8	-0.2	0.0	0.1	0.4
Risk taking	0.3	0.5	1.2	-0.7	0.9	0.3	0.1	1.1	0.7
Bipolar Disorder or Schizophrenia	0.2	0.5	1.2	-0.7	1.1	1.0	0.3	0.3	0.1
Ulcerative Colitis (UC)	0.2	0.3	0.8	0.6	-0.7	-0.0	-0.2	-0.6	-0.9
Reaction Time	0.2	0.4	1.4	1.2	-0.3	-0.6	-0.4	-0.0	-0.5
Blood Eosinophil Count	0.2	1.3	2.6	0.1	1.6	1.6	1.5	0.2	0.2
Blood Platelet Count	0.2	2.1	6.9	1.6	2.6	1.3	0.1	1.1	0.5
Hypothyroidism (self reported)	0.2	0.5	1.3	-0.3	0.2	-0.3	-0.8	1.0	1.1
Medication: Co-codamol	0.2	0.2	0.5	-0.0	-0.3	-0.6	-0.3	-0.7	-0.5
Maternal smoking around birth	0.2	0.3	0.7	-0.3	0.5	-0.7	-0.8	-0.1	0.1
Chronic bronchitis/emphysema (father)	0.2	0.2	0.6	-0.4	0.8	0.1	0.2	-0.7	-0.4
Had other major operations	0.2	0.2	0.4	0.3	0.3	0.5	0.3	0.6	0.6
Mouth/teeth dental problems	0.2	0.4	1.6	1.3	0.6	0.1	-0.1	-0.4	-0.1
Trunk fat-free mass	0.2	1.3	3.5	-0.0	1.0	-1.1	-1.9	0.6	1.3
Hip circumference	0.2	0.9	4.0	-0.8	-2.0	0.1	0.7	0.5	0.1
Pulse rate	0.2	0.3	1.0	1.0	-0.4	-0.4	-0.6	-0.1	-0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.0	-0.6	-0.1	-0.1	0.5	-1.0	-0.9
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	-0.7	0.2	-0.7	-0.3	-0.5	-0.7
Asthma	0.2	0.5	1.6	0.6	-0.4	-0.3	0.3	-0.7	-1.3
Arm fat mass (right)	0.2	0.9	3.0	-0.4	-1.7	-0.5	0.6	-0.8	-1.1
Trunk predicted mass	0.2	1.2	3.1	0.0	0.9	-1.0	-1.8	0.6	1.3
Birth weight of first child	0.2	0.4	1.3	-1.1	0.4	-0.2	-0.0	0.5	0.7
Pulse wave reflection index	0.2	0.2	0.9	-0.1	0.9	-0.3	-0.3	-0.2	-0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	-0.7	0.3	-0.0	-0.3	1.0	0.9
Arm fat-free mass (right)	0.2	1.1	2.4	-0.1	1.2	-0.5	-1.4	0.8	1.6
Age at first live birth	0.2	0.4	0.8	0.2	0.0	-0.5	-0.9	0.7	0.9
Medication for pain relief, constipation, heartburn	0.2	0.3	0.9	1.0	-0.4	-0.2	-0.0	-0.5	-0.7
Pulse rate, automated reading	0.2	0.7	1.4	-0.3	-1.2	1.1	1.1	0.5	0.3
Chest pain or discomfort	0.2	0.4	1.2	1.1	-0.8	0.2	-0.3	-0.0	0.4
Had major operations	0.2	0.3	0.7	-0.4	-0.9	-0.4	-0.4	0.5	0.5
Age at last live birth	0.2	0.3	0.7	0.5	0.1	-0.6	-0.8	0.3	0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.9	-0.1	-0.5	-0.2	0.3	-0.7	-0.9
Wears glasses or contact lenses	0.2	0.3	1.3	1.1	-0.2	0.2	-0.4	-0.2	0.3
Financial situation satisfaction	0.2	0.3	1.2	1.1	-0.5	-0.0	0.2	0.3	-0.0
Medication: Paracetamol	0.2	0.3	1.4	-0.1	1.2	0.1	0.5	-0.3	-0.1
Number of operations (self-reported)	0.2	0.2	0.8	-0.4	-0.4	0.3	0.1	0.4	0.9
Arm predicted mass (left)	0.2	1.1	2.2	0.3	1.1	-0.6	-1.4	0.8	1.5
Schizophrenia (2018)	0.1	0.1	0.2	-0.2	-0.4	0.5	0.4	-0.1	-0.2
Crohns Disease (2012)	0.1	0.2	0.6	-0.1	0.1	-0.4	-0.8	-0.6	0.1
LDL Cholesterol	0.1	0.2	0.7	-0.7	-0.9	-0.1	0.3	0.1	-0.1
Schizophrenia (2014)	0.1	0.1	0.4	0.3	-0.3	-0.1	-0.1	-0.5	-0.7
Blood Red Count	0.1	0.9	1.8	0.4	0.3	1.0	1.3	-0.8	-1.4
Hair Pigment	0.1	3.8	10.8	-1.0	-1.5	1.5	3.3	-1.0	-2.3
Hearing difficulty/problems: Yes	0.1	0.2	0.4	0.6	-0.3	0.1	0.1	-0.6	-0.5
Leg fat-free mass (left)	0.1	0.3	0.9	-0.1	0.1	-0.8	-1.0	0.2	0.4
Leg predicted mass (left)	0.1	0.3	1.0	-0.1	0.0	-0.8	-1.0	0.2	0.3
Alcohol usually taken with meals	0.1	0.2	0.5	0.6	0.1	-0.2	-0.0	-0.7	-0.7
Illnesses of siblings	0.1	0.2	0.8	0.3	0.9	0.3	0.1	-0.1	0.2
Time employed in main current job	0.1	0.1	0.4	-0.5	0.3	0.2	0.6	-0.2	-0.2
Number of live births	0.1	0.1	0.7	0.3	0.8	-0.3	0.0	-0.1	0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	-0.1	-0.5	0.4	0.4	0.0	-0.1
Wheeze or whistling in the chest in last year	0.1	0.2	0.7	0.1	-0.2	-0.5	-0.6	0.4	0.8
Whole body fat-free mass	0.1	0.7	2.1	-0.0	0.6	-0.9	-1.4	0.5	1.0
Loneliness, isolation	0.1	0.1	0.3	-0.4	-0.5	-0.5	-0.3	-0.0	0.1
Whole body water mass	0.1	0.8	2.2	0.1	0.8	-0.9	-1.5	0.5	1.0
Basal metabolic rate	0.1	0.4	1.2	0.1	-0.1	-0.9	-1.1	0.0	0.4
Arm fat-free mass (left)	0.1	0.6	1.2	0.4	1.0	-0.3	-0.9	0.6	1.1
Commuting to job workplace: Cycle	0.1	0.2	0.5	0.6	0.7	0.3	-0.0	0.2	0.0
Tanning	0.0	0.0	0.1	0.1	-0.3	0.2	0.2	0.1	-0.1
Leg fat-free mass (right)	0.0	0.2	0.6	0.1	0.1	-0.5	-0.8	0.2	0.3
Leg predicted mass (right)	0.0	0.2	0.5	0.2	0.2	-0.5	-0.7	0.3	0.4

Hub : Genes

RYK

Models

Trait associations