Hub : Genes

SLCO2A1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.1831	0.0738	0.00900	0.009	NA	-0.008	NA	-0.007	0.1500	NA	9.9e-01	NA	0.68000
2	GTEx	Nerve Tibial	0.2593	0.0641	0.00025	0.012	NA	0.086	NA	0.061	0.0440	NA	1.2e-06	NA	0.00004
3	TCGA	Prostate Adenocarcinoma	0.0871	0.0321	0.00034	0.021	0.04	0.033	NA	0.028	0.0028	4.3e-05	2.0e-04	NA	0.00063

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.7	1.0	1.5	0.8	0.9	1.2
Bipolar Disorder or Schizophrenia	0.4	1.0	2.0	0.9	-0.4	1.4
Depressed Affect (Nagel 2018)	0.6	1.4	2.9	-1.7	-0.9	0.7
Depression (Nagel 2018)	0.8	1.1	1.4	1.1	0.9	1.2
Intelligence (Savage-Jansen 2018)	0.9	2.7	4.5	-1.2	-2.1	-1.4
Neuroticism (Nagel 2018)	0.6	1.5	2.7	-1.6	-1.0	0.8
Schizophrenia (2018)	0.4	0.7	1.4	0.4	-1.2	0.8
Schizophrenia vs Biploar Disorder	0.5	0.6	1.7	-0.2	0.4	1.3
Worry (Nagel 2018)	0.3	0.7	2.0	-1.4	-0.2	0.3
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	0.5	0.1	-0.6
Alzheimer’s Disease (in father)	2.3	2.5	4.4	-1.5	-0.9	-2.1
Alzheimer’s Disease (including proxy)	1.0	1.4	3.7	-0.6	-0.3	-1.9
Crohns Disease (2017)	0.2	0.4	0.8	0.3	-0.9	-0.6
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	0.0	-0.5	-0.7
Ulcerative Colitis (UC)	0.1	0.1	0.3	0.1	-0.2	-0.6
Major Depression (MDD)	1.0	1.2	2.2	-1.1	-0.4	-1.5
Reaction Time	0.0	0.1	0.1	0.3	0.4	0.2
Verbal and Numeric Reasoning (VNR)	2.0	4.8	7.1	-2.2	-2.7	-1.5
Breast Cancer	0.3	0.6	1.8	0.1	1.3	-0.4
Ovarian Cancer	1.0	1.4	2.8	0.9	0.6	1.7
Prostate Cancer	1.3	1.8	4.4	-2.1	-0.8	-0.7
Age at First Birth	3.5	5.1	6.7	-1.4	-2.6	-2.5
Bipolar Disorder (2011)	1.0	1.0	2.8	1.7	-0.4	0.0
Body Mass Index (BMI) (2010)	2.0	2.7	8.0	-2.8	0.3	-0.2
Coronary Artery Disease (CAD)	0.5	0.6	1.6	-1.3	-0.2	-0.5
Crohns Disease (2012)	0.6	1.0	2.4	-0.1	-1.5	-0.8
Mean Putamen Volume	3.7	4.2	5.8	-1.4	-2.2	-2.4
Fasting Glucose	0.1	0.1	0.3	-0.5	-0.1	0.2
HbA1C	1.7	1.9	4.7	-2.2	-0.3	-0.9
HDL Cholesterol	0.4	0.6	1.3	0.6	-0.5	1.1
LDL Cholesterol	0.5	0.8	1.3	-0.6	0.9	-1.1
Lupus	0.1	0.2	0.7	0.8	-0.1	-0.1
Neuroticism (2016)	2.6	3.7	7.8	-1.5	-2.8	-0.9
Primary Biliary Cirrhosis	0.1	0.1	0.1	-0.2	-0.3	-0.3
Rheumatoid Arthritis	5.1	7.0	8.8	2.6	2.3	3.0
Schizophrenia (2014)	0.7	1.6	4.3	0.3	-0.6	2.1
Triglycerides	0.4	0.7	1.3	-1.1	0.7	-0.6
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.5	-1.6	0.9	1.0
Ulcerative Colitis	0.1	0.1	0.2	-0.2	0.1	-0.4
Blood Eosinophil Count	0.1	1.0	2.2	0.4	0.9	1.5
Blood Platelet Count	0.1	0.7	1.5	0.6	0.3	-1.2
Blood Red Count	0.3	2.9	8.6	2.9	-0.2	0.4
Blood White Count	0.1	1.0	1.6	-1.3	-0.9	-0.8
Heel T-Score	1.5	12.3	25.5	0.2	5.0	3.4
BMI	0.3	1.8	2.5	0.9	1.4	1.6
Height	0.7	14.3	23.2	-4.8	-1.9	-4.0
Waist Hip Ratio (WHR)	0.2	1.1	1.7	-1.0	0.8	1.3
Systolic Blood Pressure	5.3	26.3	42.6	-6.5	-4.2	-4.4
Smoking Status	0.2	0.5	0.6	0.7	-0.8	-0.7
Allergy or Eczema	0.4	1.0	2.0	0.5	1.4	0.9
Cardiovascular Disease	3.0	9.9	24.7	-5.0	-1.6	-1.6
Hypothyroidism (self reported)	0.4	0.8	1.6	-1.2	-0.1	1.0
Respiratory disease	0.2	0.5	1.2	0.1	0.4	1.1
Type 2 Diabetes (T2D) (2018)	0.9	1.6	3.0	1.7	0.9	1.0
Lung FEV1/FVC ratio	0.2	1.2	2.6	1.6	-1.0	-0.2
Lung FVC	0.7	3.6	6.1	-1.2	-1.8	-2.5
Neuroticism	0.8	2.0	3.4	-1.9	-0.1	1.6
Chronotype (morning person)	0.6	1.3	1.8	-1.3	-0.7	-1.4
Hair Pigment	0.1	2.7	6.4	2.5	1.2	-0.6
Tanning	0.3	3.7	7.1	0.9	-1.7	-2.7
Hand grip strength (left)	1.0	2.5	4.4	-2.1	-0.3	-1.8
Number of treatments/medications taken	0.4	0.7	1.3	-0.5	-0.7	-1.2
Average weekly spirits intake	1.9	2.3	3.2	-1.8	-1.3	-1.5
Sensitivity / hurt feelings	0.4	0.8	1.7	-0.6	-1.3	0.4
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	-0.1	0.7	0.2
Hearing difficulty/problems: Yes	0.2	0.2	0.5	-0.1	0.4	0.7
Relative age of first facial hair	0.7	1.5	2.3	0.3	-1.5	-1.4
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.9	0.8	-0.6	-1.4
Ever used hormone-replacement therapy (HRT)	1.3	1.6	2.8	-1.7	0.7	1.2
Ever had hysterectomy (womb removed)	1.0	1.2	3.1	0.1	1.8	0.7
Systolic blood pressure, automated reading	2.2	6.5	7.0	-2.6	-2.3	-2.7
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.1	1.8	-0.3	0.6
Angina	2.0	2.7	3.8	-1.9	-0.8	-2.0
Medication for hormone replacement therapy	1.4	1.5	3.4	-0.7	0.9	1.8
Vitamin and mineral supplements	2.2	3.0	3.9	-1.4	2.0	1.8
Supplements: Zinc	0.7	0.8	1.1	0.4	1.0	1.1
Medication: Co-codamol	0.7	0.8	1.8	-0.6	0.4	-1.3
Medication: Metformin	0.2	0.3	0.6	0.5	-0.0	0.8
Diabetes (father)	0.3	0.4	1.0	-0.4	1.0	-0.4
Diabetes (mother)	0.3	0.4	0.6	0.8	-0.5	0.7
Severe depression (siblings)	0.6	0.7	1.0	1.0	-0.4	1.0
Pack years adult smoking proportion	1.6	2.5	3.7	-1.6	-1.9	-1.1
Impedance of leg (right)	0.6	2.8	7.0	-2.6	0.9	-0.6
Leg fat-free mass (left)	0.1	0.3	0.8	-0.2	-0.9	0.1
Trunk fat percentage	0.2	0.9	1.2	-1.1	0.7	1.0
Hand grip strength (right)	0.5	1.3	3.3	-1.8	-0.1	-0.8
Townsend deprivation index at recruitment	0.4	0.5	0.9	-0.7	0.1	-1.0
Current tobacco smoking	0.9	1.4	1.9	-1.4	-1.2	-0.9
Average weekly fortified wine intake	0.3	0.3	1.0	-0.1	-0.1	-1.0
Maternal smoking around birth	0.3	0.5	0.8	-0.9	-0.6	-0.5
Fed-up feelings	0.6	1.0	1.8	-1.3	-0.8	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	0.7	0.9	0.6	0.8
Relative age voice broke	0.3	0.4	0.5	-0.7	-0.4	-0.7
Taking other prescription medications	0.1	0.1	0.2	0.5	-0.2	0.1
Age when periods started (menarche)	1.2	2.8	6.3	0.9	-2.5	-1.1
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	4.9	0.4	2.2	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	4.6	2.1	1.2	0.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	0.9	-0.9	-0.5	-0.8
Qualifications: CSEs or equivalent	0.4	0.5	1.0	1.0	-0.6	0.4
Serious illness, injury or assault to yourself	0.6	0.7	1.5	-1.2	-0.5	0.7
High blood pressure	4.0	11.1	22.7	-4.8	-2.2	-2.4
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.3	0.1	0.5	0.1
Multivitamins +/- minerals	0.7	0.8	1.6	1.3	-0.9	-0.2
Stomach or abdominal pain in last month	0.7	0.9	2.1	-1.4	0.7	-0.1
Supplements: Glucosamine	1.6	2.1	3.9	2.0	-1.3	-0.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	1.0	1.0	-0.8	-0.8
Medication: Atenolol	2.7	3.3	5.3	-1.9	-1.1	-2.3
Medication: Levothyroxine sodium	0.5	0.8	1.7	-0.6	0.6	1.3
Sitting height	0.2	1.4	2.2	-1.0	-1.0	-1.5
Chronic bronchitis/emphysema (father)	0.4	0.4	1.1	0.3	1.1	0.2
High blood pressure (mother)	0.1	0.2	0.3	-0.6	-0.3	0.2
Body mass index (BMI)	0.2	1.0	1.8	1.3	0.4	1.0
Impedance of leg (left)	0.4	2.0	4.0	-2.0	1.2	-0.7
Leg predicted mass (left)	0.1	0.3	0.8	-0.2	-0.9	0.1
Trunk fat mass	0.2	0.7	0.8	-0.9	0.7	0.9
Waist circumference	0.1	0.4	1.2	-0.1	0.4	1.1
Number of incorrect matches in round	0.4	0.7	1.1	0.9	1.1	-0.2
Past tobacco smoking	0.3	0.6	1.1	-1.0	0.1	0.8
Alcohol usually taken with meals	0.4	0.6	1.5	-0.5	-0.3	1.2
Nervous feelings	0.2	0.4	1.2	0.1	-1.1	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.8	0.9	0.1	0.5
Hearing difficulty/problems with background noise	0.6	0.9	1.4	-0.8	-0.9	1.2
Hair/balding pattern: Pattern 2	0.7	0.9	2.2	0.7	0.2	1.5
Had menopause	1.0	1.2	1.3	1.1	1.1	1.1
Had other major operations	0.0	0.1	0.1	0.1	0.2	-0.3
Forced vital capacity (FVC)	0.7	2.8	5.9	-1.4	-0.7	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	5.2	2.3	1.8	1.3
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.9	-0.5	-1.4	0.0
Qualifications: None of the above	0.4	0.9	1.2	-0.6	1.1	-1.1
Financial difficulties in last 2 years	0.2	0.2	0.6	0.1	0.8	-0.2
Mouth/teeth dental problems	2.6	4.0	7.5	1.2	-1.8	-2.7
Heart attack	3.2	4.1	6.9	-0.7	-2.2	-2.6
Allergy	0.0	0.1	0.2	0.5	0.1	0.1
Pain all over the body in last month	0.2	0.3	0.5	0.7	0.3	-0.4
Diabetes (self-reported)	0.9	1.4	3.0	1.7	0.9	0.7
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.1	-0.6	1.1	1.5
Medication: Ramipril	4.0	5.2	10.9	-1.5	-1.5	-3.3
Medication: Simvastatin	1.6	2.3	5.0	-2.2	-0.8	-1.1
Fluid intelligence score	2.0	4.2	7.6	-1.8	-2.8	-1.3
Illnesses of siblings	0.1	0.1	0.2	-0.5	0.1	0.3
Neuroticism score	0.7	1.4	3.7	-1.9	-0.7	0.5
Weight	0.0	0.1	0.2	-0.2	0.4	0.5
Impedance of arm (right)	0.7	3.1	9.4	-3.1	-0.0	-0.2
Arm fat percentage (right)	0.0	0.1	0.2	-0.4	-0.0	0.4
Trunk fat-free mass	0.0	0.1	0.1	-0.3	-0.3	-0.2
Hip circumference	0.1	0.4	0.8	0.5	0.1	0.9
Time employed in main current job	1.5	1.8	3.1	0.5	1.4	1.8
Alcohol intake versus 10 years previously	0.9	1.4	4.0	-0.2	-0.4	-2.0
Father’s age at death	2.1	2.8	4.3	0.5	2.0	2.1
Worrier / anxious feelings	1.1	2.1	5.2	-2.3	-0.6	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	0.7	-0.1	0.6
Falls in the last year	0.4	0.5	1.0	-0.7	0.1	-1.0
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.9	-0.3	-0.1
Number of live births	0.1	0.1	0.3	-0.3	0.5	0.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.9	-0.7	-0.7	-1.7
Pulse rate	0.6	1.0	1.6	0.1	1.2	1.3
Happiness	0.5	0.6	1.0	1.0	0.1	0.9
Noisy workplace	3.3	4.0	4.8	-2.2	1.7	2.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.3	0.4	-0.5	-1.5
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	3.4	-0.5	1.9	-0.1
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	-0.5	-0.8	-0.3
Asthma	0.1	0.3	0.5	0.2	0.7	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.7	1.3	-0.1	1.1
Medication: Cholesterol lowering	0.7	1.1	1.5	-1.2	-1.2	-0.7
Depression (self-reported)	1.7	2.0	5.1	-2.2	-0.7	-0.7
Medication: Lansoprazole	0.9	1.1	1.6	1.3	-0.8	-1.0
Prospective memory result	1.7	2.1	3.9	-0.2	2.0	1.5
Lung cancer (father)	0.4	0.4	0.8	0.9	-0.6	-0.4
Illnesses of mother	0.2	0.2	0.5	0.1	0.3	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.8	-0.6	-0.4	-0.9
Pulse wave Arterial Stiffness index	0.7	0.8	1.3	-0.8	-0.6	-1.1
Impedance of arm (left)	1.0	4.6	13.7	-3.7	-0.2	-0.2
Arm fat mass (right)	0.0	0.1	0.1	-0.4	0.0	0.2
Trunk predicted mass	0.0	0.0	0.1	-0.2	-0.3	-0.2
Standing height	0.5	4.6	13.1	-3.6	0.1	-0.9
Length of working week for main job	1.7	1.9	2.4	-1.5	-1.1	-1.6
Exposure to tobacco smoke at home	0.4	0.5	1.0	-1.0	0.6	-0.2
Breastfed as a baby	0.8	0.9	1.8	-0.8	-0.6	-1.4
Tense / ‘highly strung’	0.6	1.0	1.4	-1.1	-1.2	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	3.7	-1.4	-1.9	-0.4
Hair/balding pattern: Pattern 4	0.4	0.9	1.9	-0.9	1.4	0.4
Birth weight of first child	1.2	2.1	3.5	-0.2	1.7	1.9
Peak expiratory flow (PEF)	0.1	0.1	0.2	-0.5	-0.1	-0.4
Pulse wave reflection index	0.4	0.5	0.6	-0.7	-0.8	-0.6
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.2	-1.5	-1.2	-0.5
Loud music exposure frequency	0.7	0.7	1.3	0.9	0.2	1.1
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.7	1.3	0.6	0.8
Mouth/teeth dental problems: Bleeding gums	2.0	2.5	5.3	-1.2	0.9	2.3
Blood clot in the leg (DVT)	0.6	0.8	1.6	0.7	-1.2	0.4
Medication: Paracetamol	1.2	2.0	2.7	-1.0	-1.6	-1.5
Headache pain in last month	1.4	2.4	5.8	1.1	-2.4	-0.3
Medication for cholesterol, blood pressure or diabetes	1.8	2.9	4.5	2.1	1.5	1.4
Glaucoma (self-reported)	0.4	0.4	0.7	-0.6	-0.8	-0.5
Gout (self-reported)	1.6	2.1	3.5	1.9	1.1	1.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.4	-0.7	0.7	1.2
Medication: Amlodipine	1.7	2.4	4.9	-2.2	-1.3	-0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.6	0.3	0.8	0.6
Birth weight	0.8	1.8	3.8	1.2	-0.3	-2.0
Chronic bronchitis/emphysema (mother)	3.0	3.5	6.6	-0.1	2.0	2.6
High blood pressure (siblings)	0.2	0.4	0.5	-0.7	0.6	0.4
Forced vital capacity (FVC), Best measure	0.3	1.2	2.3	-1.1	-0.2	-1.5
Body fat percentage	0.2	0.6	0.9	-0.6	0.8	0.9
Leg fat percentage (right)	0.2	0.8	1.3	0.3	1.1	1.0
Arm fat-free mass (right)	0.0	0.0	0.1	0.3	-0.0	-0.2
Exposure to tobacco smoke outside home	0.5	0.7	1.7	-0.2	0.7	1.3
Comparative body size at age 10	1.6	4.5	12.2	3.5	-1.0	0.4
Number of full brothers	1.3	1.6	2.8	0.6	1.3	1.7
Worry too long after embarrassment	1.4	2.3	4.2	-1.4	-1.0	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.4	-0.1	0.3
Wheeze or whistling in the chest in last year	0.0	0.1	0.2	-0.3	-0.1	-0.4
Number of children fathered	0.3	0.3	0.5	-0.7	-0.6	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.3	1.5	-0.0	0.7
Age at first live birth	0.7	1.2	3.3	-0.2	-1.8	-0.5
Pulse wave peak to peak time	0.5	0.5	1.0	0.4	0.7	1.0
Health satisfaction	0.1	0.2	0.3	-0.4	-0.6	-0.2
Shortness of breath walking on level ground	0.7	0.8	1.7	0.9	1.3	0.2
Qualifications: College or University degree	0.3	1.0	1.8	-0.8	-0.6	-1.4
Eye problems/disorders: None of the above	3.5	4.1	4.5	1.9	2.0	2.1
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.1	-1.1	-0.3	-0.2
Emphysema/chronic bronchitis	1.0	1.1	1.9	-1.0	-1.4	-0.6
Medication for pain relief, constipation, heartburn	0.2	0.4	0.6	0.8	0.8	-0.2
Neck or shoulder pain in last month	0.1	0.1	0.3	0.5	-0.3	-0.2
Medication: Blood pressure	4.1	7.3	12.4	-3.5	-2.1	-2.3
Angina (self-reported)	1.6	2.1	2.7	-1.6	-1.0	-1.6
Migraine (self-reported)	0.7	0.9	2.7	1.6	-0.3	0.0
Medication: Ibuprofen	0.2	0.3	0.4	0.6	-0.3	0.6
Medication: Allopurinol	0.2	0.3	0.9	0.9	-0.0	-0.2
Medication: Omeprazole	1.4	1.6	2.8	0.5	1.4	1.7
Medication: Seretide 50 evohaler	2.8	3.2	5.7	-0.7	-1.9	-2.4
Mean time to correctly identify matches	0.4	0.7	0.8	0.9	0.8	0.8
Heart disease (mother)	0.4	0.5	0.7	-0.7	-0.8	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	5.5	2.4	0.1	0.2
Whole body fat mass	0.1	0.3	0.4	-0.5	0.5	0.7
Leg fat mass (right)	0.0	0.1	0.2	0.0	0.4	0.4
Arm predicted mass (right)	0.0	0.1	0.1	0.1	-0.2	-0.3
Pulse rate, automated reading	1.0	3.2	6.8	0.7	2.6	1.5
Alcohol intake frequency.	1.0	2.4	5.5	2.3	-0.4	1.2
Comparative height size at age 10	0.6	3.2	7.5	-2.7	1.4	-0.0
Number of full sisters	3.7	4.5	7.7	1.3	2.0	2.8
Suffer from ‘nerves’	0.0	0.0	0.0	-0.1	0.0	-0.1
Overall health rating	0.6	1.3	2.9	0.0	-0.9	-1.7
Chest pain or discomfort	0.2	0.3	0.6	-0.5	0.1	-0.8
Had major operations	0.1	0.1	0.4	0.1	0.6	-0.0
Age at last live birth	3.3	4.8	8.6	-0.5	-2.9	-2.3
Family relationship satisfaction	0.2	0.2	0.3	-0.5	-0.5	-0.5
Leg pain on walking	0.5	0.6	1.2	1.1	0.6	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.1	1.3	-0.2	1.5
Commuting to job workplace: Car/motor vehicle	0.9	1.1	2.2	1.5	-0.4	-1.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	0.1	-0.9	0.3
Medication: Aspirin	0.7	1.0	2.1	-0.5	-1.4	-0.7
Supplements: Vitamin C	0.7	0.9	1.1	-0.7	-1.0	-1.0
Knee pain experienced in last month	0.3	0.5	1.4	-0.4	1.2	0.1
Hypertension (Self-reported)	3.5	9.8	19.6	-4.4	-2.1	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.8	-1.7	0.6	0.1
Illnesses of father: Heart disease	1.3	1.8	3.7	-0.8	-1.1	-1.9
Illnesses of siblings: Diabetes	0.4	0.5	0.8	0.6	0.9	0.4
Smoking status: Previous	0.5	0.8	2.0	1.4	0.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.1	0.2	1.0	1.8
Whole body fat-free mass	0.0	0.1	0.4	-0.1	-0.6	-0.1
Leg fat-free mass (right)	0.1	0.3	0.9	0.1	-0.9	-0.1
Arm fat percentage (left)	0.0	0.2	0.4	-0.6	0.1	0.4
Average weekly red wine intake	0.2	0.3	0.6	0.2	-0.3	0.8
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	0.6	-0.1	-0.9
Mood swings	0.8	1.5	2.9	-1.7	-1.2	-0.4
Loneliness, isolation	0.3	0.4	0.9	-0.5	-0.9	0.5
Long-standing illness, disability or infirmity	0.5	0.8	1.3	0.8	1.2	0.6
Ever had bowel cancer screening	0.6	0.7	1.0	1.0	0.9	-0.6
Diabetes diagnosed by doctor	0.7	1.2	3.6	1.9	0.1	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.3	1.2	1.5	0.6
Friendships satisfaction	0.2	0.2	0.5	-0.1	-0.4	0.7
Qualifications: nursing, teaching	0.3	0.5	0.7	0.7	0.8	0.6
Commuting to job workplace: Walk	2.3	2.5	6.5	2.5	0.6	0.7
Eye problems/disorders: Cataract	2.0	2.3	2.9	-1.7	-1.6	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.6	-0.3	0.8	0.8
Medication for cholesterol	0.5	0.7	1.8	1.3	-0.1	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.1	0.1	0.0	-0.4	0.2
Back pain experienced in last month	0.3	0.5	0.5	0.7	-0.7	-0.7
Mineral and other dietary supplements	1.2	1.5	2.8	-1.7	1.2	0.6
Breast cancer (self-reported)	0.2	0.2	0.3	-0.5	-0.5	-0.3
Asthma (self-reported)	0.2	0.3	0.7	0.4	0.8	0.3
Osteoporosis (self-reported)	1.5	1.8	3.4	1.8	1.4	0.4
Osteoarthritis (self-reported)	0.2	0.2	0.2	0.5	-0.5	-0.3
Medication: Aspirin	0.6	0.8	1.6	-0.7	-1.2	-0.6
Medication: Gliclazide	0.2	0.2	0.5	0.2	-0.7	-0.2
Illnesses of father: None of the above (group 1)	0.6	0.7	1.1	1.1	-1.0	-0.0
Smoking status: Current	0.9	1.4	1.9	-1.1	-1.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.8	-1.4	-0.9	-0.4
Whole body water mass	0.0	0.1	0.2	-0.0	-0.5	-0.2
Leg predicted mass (right)	0.1	0.3	0.8	0.2	-0.9	0.0
Arm fat mass (left)	0.0	0.1	0.2	-0.4	0.1	0.3
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.6	0.2	0.4
Average weekly champagne plus white wine intake	0.0	0.1	0.1	-0.4	0.2	0.0
Miserableness	0.3	0.5	1.3	-1.1	-0.5	-0.0
Guilty feelings	0.6	1.0	1.8	-1.3	-0.8	-0.7
Wears glasses or contact lenses	0.4	0.4	0.8	0.1	0.7	0.9
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.3	0.7	0.3
Hearing aid user	2.8	3.1	7.7	-2.8	-0.8	-1.0
Mother’s age at death	0.8	0.9	2.0	-1.4	0.9	-0.0
Financial situation satisfaction	0.2	0.3	0.7	0.8	-0.3	-0.0
Tinnitus: Yes, now most or all of the time	0.6	0.6	0.8	-0.8	0.9	0.7
Commuting to job workplace: Public transport	1.6	1.9	3.8	-0.9	1.1	1.9
Eye problems/disorders: Glaucoma	1.0	1.2	1.7	-1.1	-1.3	-0.9
Medication: Blood pressure	1.4	2.7	3.6	-1.9	-1.0	-1.9
Pain type(s) experienced in last month: Hip pain	2.2	2.7	7.1	2.7	0.3	1.0
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	0.4	-0.6	-0.1
High cholesterol (Self-reported)	0.7	1.2	3.0	-1.7	-0.7	0.3
Medication: Bendroflumethiazide	0.3	0.5	0.9	-1.0	-0.1	-0.7
Medication: Paracetamol	0.4	0.7	1.0	-0.7	-0.8	-1.0
Medication: Lisinopril	1.4	1.8	3.3	-1.8	-0.4	-1.4
Medication: Atorvastatin	0.5	0.6	1.5	-0.5	-1.2	-0.2
Illnesses of father: High blood pressure	0.6	0.8	1.7	-1.3	0.7	-0.5
Alcohol drinker status: Never	0.5	0.6	1.0	0.2	0.9	1.0
Ever smoked	0.1	0.1	0.4	0.3	-0.0	-0.6
Basal metabolic rate	0.0	0.1	0.2	-0.1	-0.5	-0.2
Leg fat percentage (left)	0.3	1.1	2.0	0.6	1.4	0.9
Arm fat-free mass (left)	0.0	0.2	0.5	0.7	0.3	0.1
Number of operations (self-reported)	0.2	0.2	0.7	0.2	0.8	-0.0
Average weekly beer plus cider intake	1.0	1.5	3.5	-0.8	-0.5	-1.9
Irritability	0.5	0.9	2.4	-1.6	0.5	-0.0
Risk taking	0.3	0.5	0.8	0.3	0.9	-0.8
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.0	0.8	-0.1
Fractured/broken bones in last 5 years	0.2	0.2	0.5	0.3	-0.7	-0.2
Age started oral contraceptive pill	0.3	0.4	1.0	-0.4	0.3	-1.0
Diastolic blood pressure, automated reading	2.2	6.8	10.2	-3.2	-2.3	-2.3
Ever depressed for a whole week	1.8	2.2	5.3	2.3	-0.9	-0.7
Unable to work because of sickness or disability	0.1	0.1	0.1	0.3	0.3	-0.3
Commuting to job workplace: Cycle	0.1	0.1	0.3	-0.5	-0.3	-0.2
Myopia	0.4	0.5	1.2	-0.4	-0.5	-1.1
Vascular/heart problems diagnosed by doctor	5.0	13.7	24.9	5.0	2.5	3.2
Cholesterol lowering medication	0.5	0.7	1.8	-1.4	0.3	0.3
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	3.6	0.5	1.9	1.9
Pain experienced in last month	0.1	0.1	0.2	-0.5	-0.1	0.3
Supplements: Calcium	1.0	1.1	2.9	1.7	-0.6	-0.1
Basal cell carcinoma (self-reported)	0.7	0.8	1.5	-1.2	-0.2	-0.9
Heart attack/myocardial infarction (self-reported)	2.9	3.8	6.4	-0.5	-2.1	-2.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.0	0.4	-1.4	0.1
Heart disease (siblings)	1.6	2.0	2.8	1.7	1.6	0.7
Alcohol drinker status: Previous	0.5	0.6	0.8	0.6	-0.9	0.7
Pack years of smoking	2.4	3.5	4.6	-2.0	-2.1	-1.4
Impedance of whole body	0.7	3.4	9.9	-3.1	0.4	-0.3
Leg fat mass (left)	0.1	0.2	0.4	0.3	0.7	0.4
Arm predicted mass (left)	0.0	0.0	0.0	0.2	-0.0	-0.1