Hub : Genes

SLCO2A1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.1831 0.0738 0.00900 0.009 NA -0.008 NA -0.007 0.1500 NA 9.9e-01 NA 0.68000
2 GTEx Nerve Tibial 0.2593 0.0641 0.00025 0.012 NA 0.086 NA 0.061 0.0440 NA 1.2e-06 NA 0.00004
3 TCGA Prostate Adenocarcinoma 0.0871 0.0321 0.00034 0.021 0.04 0.033 NA 0.028 0.0028 4.3e-05 2.0e-04 NA 0.00063

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.7 1.0 1.5 0.8 0.9 1.2
Bipolar Disorder or Schizophrenia 0.4 1.0 2.0 0.9 -0.4 1.4
Depressed Affect (Nagel 2018) 0.6 1.4 2.9 -1.7 -0.9 0.7
Depression (Nagel 2018) 0.8 1.1 1.4 1.1 0.9 1.2
Intelligence (Savage-Jansen 2018) 0.9 2.7 4.5 -1.2 -2.1 -1.4
Neuroticism (Nagel 2018) 0.6 1.5 2.7 -1.6 -1.0 0.8
Schizophrenia (2018) 0.4 0.7 1.4 0.4 -1.2 0.8
Schizophrenia vs Biploar Disorder 0.5 0.6 1.7 -0.2 0.4 1.3
Worry (Nagel 2018) 0.3 0.7 2.0 -1.4 -0.2 0.3
Alzheimer’s Disease (in mother) 0.2 0.2 0.4 0.5 0.1 -0.6
Alzheimer’s Disease (in father) 2.3 2.5 4.4 -1.5 -0.9 -2.1
Alzheimer’s Disease (including proxy) 1.0 1.4 3.7 -0.6 -0.3 -1.9
Crohns Disease (2017) 0.2 0.4 0.8 0.3 -0.9 -0.6
Irritable Bowel Disease (IBD) 0.1 0.2 0.5 0.0 -0.5 -0.7
Ulcerative Colitis (UC) 0.1 0.1 0.3 0.1 -0.2 -0.6
Major Depression (MDD) 1.0 1.2 2.2 -1.1 -0.4 -1.5
Reaction Time 0.0 0.1 0.1 0.3 0.4 0.2
Verbal and Numeric Reasoning (VNR) 2.0 4.8 7.1 -2.2 -2.7 -1.5
Breast Cancer 0.3 0.6 1.8 0.1 1.3 -0.4
Ovarian Cancer 1.0 1.4 2.8 0.9 0.6 1.7
Prostate Cancer 1.3 1.8 4.4 -2.1 -0.8 -0.7
Age at First Birth 3.5 5.1 6.7 -1.4 -2.6 -2.5
Bipolar Disorder (2011) 1.0 1.0 2.8 1.7 -0.4 0.0
Body Mass Index (BMI) (2010) 2.0 2.7 8.0 -2.8 0.3 -0.2
Coronary Artery Disease (CAD) 0.5 0.6 1.6 -1.3 -0.2 -0.5
Crohns Disease (2012) 0.6 1.0 2.4 -0.1 -1.5 -0.8
Mean Putamen Volume 3.7 4.2 5.8 -1.4 -2.2 -2.4
Fasting Glucose 0.1 0.1 0.3 -0.5 -0.1 0.2
HbA1C 1.7 1.9 4.7 -2.2 -0.3 -0.9
HDL Cholesterol 0.4 0.6 1.3 0.6 -0.5 1.1
LDL Cholesterol 0.5 0.8 1.3 -0.6 0.9 -1.1
Lupus 0.1 0.2 0.7 0.8 -0.1 -0.1
Neuroticism (2016) 2.6 3.7 7.8 -1.5 -2.8 -0.9
Primary Biliary Cirrhosis 0.1 0.1 0.1 -0.2 -0.3 -0.3
Rheumatoid Arthritis 5.1 7.0 8.8 2.6 2.3 3.0
Schizophrenia (2014) 0.7 1.6 4.3 0.3 -0.6 2.1
Triglycerides 0.4 0.7 1.3 -1.1 0.7 -0.6
Type 2 Diabetes (T2D) (2012) 1.2 1.4 2.5 -1.6 0.9 1.0
Ulcerative Colitis 0.1 0.1 0.2 -0.2 0.1 -0.4
Blood Eosinophil Count 0.1 1.0 2.2 0.4 0.9 1.5
Blood Platelet Count 0.1 0.7 1.5 0.6 0.3 -1.2
Blood Red Count 0.3 2.9 8.6 2.9 -0.2 0.4
Blood White Count 0.1 1.0 1.6 -1.3 -0.9 -0.8
Heel T-Score 1.5 12.3 25.5 0.2 5.0 3.4
BMI 0.3 1.8 2.5 0.9 1.4 1.6
Height 0.7 14.3 23.2 -4.8 -1.9 -4.0
Waist Hip Ratio (WHR) 0.2 1.1 1.7 -1.0 0.8 1.3
Systolic Blood Pressure 5.3 26.3 42.6 -6.5 -4.2 -4.4
Smoking Status 0.2 0.5 0.6 0.7 -0.8 -0.7
Allergy or Eczema 0.4 1.0 2.0 0.5 1.4 0.9
Cardiovascular Disease 3.0 9.9 24.7 -5.0 -1.6 -1.6
Hypothyroidism (self reported) 0.4 0.8 1.6 -1.2 -0.1 1.0
Respiratory disease 0.2 0.5 1.2 0.1 0.4 1.1
Type 2 Diabetes (T2D) (2018) 0.9 1.6 3.0 1.7 0.9 1.0
Lung FEV1/FVC ratio 0.2 1.2 2.6 1.6 -1.0 -0.2
Lung FVC 0.7 3.6 6.1 -1.2 -1.8 -2.5
Neuroticism 0.8 2.0 3.4 -1.9 -0.1 1.6
Chronotype (morning person) 0.6 1.3 1.8 -1.3 -0.7 -1.4
Hair Pigment 0.1 2.7 6.4 2.5 1.2 -0.6
Tanning 0.3 3.7 7.1 0.9 -1.7 -2.7
Hand grip strength (left) 1.0 2.5 4.4 -2.1 -0.3 -1.8
Number of treatments/medications taken 0.4 0.7 1.3 -0.5 -0.7 -1.2
Average weekly spirits intake 1.9 2.3 3.2 -1.8 -1.3 -1.5
Sensitivity / hurt feelings 0.4 0.8 1.7 -0.6 -1.3 0.4
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.5 -0.1 0.7 0.2
Hearing difficulty/problems: Yes 0.2 0.2 0.5 -0.1 0.4 0.7
Relative age of first facial hair 0.7 1.5 2.3 0.3 -1.5 -1.4
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.9 0.8 -0.6 -1.4
Ever used hormone-replacement therapy (HRT) 1.3 1.6 2.8 -1.7 0.7 1.2
Ever had hysterectomy (womb removed) 1.0 1.2 3.1 0.1 1.8 0.7
Systolic blood pressure, automated reading 2.2 6.5 7.0 -2.6 -2.3 -2.7
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 3.1 1.8 -0.3 0.6
Angina 2.0 2.7 3.8 -1.9 -0.8 -2.0
Medication for hormone replacement therapy 1.4 1.5 3.4 -0.7 0.9 1.8
Vitamin and mineral supplements 2.2 3.0 3.9 -1.4 2.0 1.8
Supplements: Zinc 0.7 0.8 1.1 0.4 1.0 1.1
Medication: Co-codamol 0.7 0.8 1.8 -0.6 0.4 -1.3
Medication: Metformin 0.2 0.3 0.6 0.5 -0.0 0.8
Diabetes (father) 0.3 0.4 1.0 -0.4 1.0 -0.4
Diabetes (mother) 0.3 0.4 0.6 0.8 -0.5 0.7
Severe depression (siblings) 0.6 0.7 1.0 1.0 -0.4 1.0
Pack years adult smoking proportion 1.6 2.5 3.7 -1.6 -1.9 -1.1
Impedance of leg (right) 0.6 2.8 7.0 -2.6 0.9 -0.6
Leg fat-free mass (left) 0.1 0.3 0.8 -0.2 -0.9 0.1
Trunk fat percentage 0.2 0.9 1.2 -1.1 0.7 1.0
Hand grip strength (right) 0.5 1.3 3.3 -1.8 -0.1 -0.8
Townsend deprivation index at recruitment 0.4 0.5 0.9 -0.7 0.1 -1.0
Current tobacco smoking 0.9 1.4 1.9 -1.4 -1.2 -0.9
Average weekly fortified wine intake 0.3 0.3 1.0 -0.1 -0.1 -1.0
Maternal smoking around birth 0.3 0.5 0.8 -0.9 -0.6 -0.5
Fed-up feelings 0.6 1.0 1.8 -1.3 -0.8 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 0.7 0.9 0.6 0.8
Relative age voice broke 0.3 0.4 0.5 -0.7 -0.4 -0.7
Taking other prescription medications 0.1 0.1 0.2 0.5 -0.2 0.1
Age when periods started (menarche) 1.2 2.8 6.3 0.9 -2.5 -1.1
Bilateral oophorectomy (both ovaries removed) 1.9 2.2 4.9 0.4 2.2 1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.0 4.6 2.1 1.2 0.3
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 0.9 -0.9 -0.5 -0.8
Qualifications: CSEs or equivalent 0.4 0.5 1.0 1.0 -0.6 0.4
Serious illness, injury or assault to yourself 0.6 0.7 1.5 -1.2 -0.5 0.7
High blood pressure 4.0 11.1 22.7 -4.8 -2.2 -2.4
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.3 0.1 0.5 0.1
Multivitamins +/- minerals 0.7 0.8 1.6 1.3 -0.9 -0.2
Stomach or abdominal pain in last month 0.7 0.9 2.1 -1.4 0.7 -0.1
Supplements: Glucosamine 1.6 2.1 3.9 2.0 -1.3 -0.9
Diverticular disease/diverticulitis (self-reported) 0.6 0.8 1.0 1.0 -0.8 -0.8
Medication: Atenolol 2.7 3.3 5.3 -1.9 -1.1 -2.3
Medication: Levothyroxine sodium 0.5 0.8 1.7 -0.6 0.6 1.3
Sitting height 0.2 1.4 2.2 -1.0 -1.0 -1.5
Chronic bronchitis/emphysema (father) 0.4 0.4 1.1 0.3 1.1 0.2
High blood pressure (mother) 0.1 0.2 0.3 -0.6 -0.3 0.2
Body mass index (BMI) 0.2 1.0 1.8 1.3 0.4 1.0
Impedance of leg (left) 0.4 2.0 4.0 -2.0 1.2 -0.7
Leg predicted mass (left) 0.1 0.3 0.8 -0.2 -0.9 0.1
Trunk fat mass 0.2 0.7 0.8 -0.9 0.7 0.9
Waist circumference 0.1 0.4 1.2 -0.1 0.4 1.1
Number of incorrect matches in round 0.4 0.7 1.1 0.9 1.1 -0.2
Past tobacco smoking 0.3 0.6 1.1 -1.0 0.1 0.8
Alcohol usually taken with meals 0.4 0.6 1.5 -0.5 -0.3 1.2
Nervous feelings 0.2 0.4 1.2 0.1 -1.1 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 0.8 0.9 0.1 0.5
Hearing difficulty/problems with background noise 0.6 0.9 1.4 -0.8 -0.9 1.2
Hair/balding pattern: Pattern 2 0.7 0.9 2.2 0.7 0.2 1.5
Had menopause 1.0 1.2 1.3 1.1 1.1 1.1
Had other major operations 0.0 0.1 0.1 0.1 0.2 -0.3
Forced vital capacity (FVC) 0.7 2.8 5.9 -1.4 -0.7 -2.4
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.4 5.2 2.3 1.8 1.3
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.9 -0.5 -1.4 0.0
Qualifications: None of the above 0.4 0.9 1.2 -0.6 1.1 -1.1
Financial difficulties in last 2 years 0.2 0.2 0.6 0.1 0.8 -0.2
Mouth/teeth dental problems 2.6 4.0 7.5 1.2 -1.8 -2.7
Heart attack 3.2 4.1 6.9 -0.7 -2.2 -2.6
Allergy 0.0 0.1 0.2 0.5 0.1 0.1
Pain all over the body in last month 0.2 0.3 0.5 0.7 0.3 -0.4
Diabetes (self-reported) 0.9 1.4 3.0 1.7 0.9 0.7
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 2.1 -0.6 1.1 1.5
Medication: Ramipril 4.0 5.2 10.9 -1.5 -1.5 -3.3
Medication: Simvastatin 1.6 2.3 5.0 -2.2 -0.8 -1.1
Fluid intelligence score 2.0 4.2 7.6 -1.8 -2.8 -1.3
Illnesses of siblings 0.1 0.1 0.2 -0.5 0.1 0.3
Neuroticism score 0.7 1.4 3.7 -1.9 -0.7 0.5
Weight 0.0 0.1 0.2 -0.2 0.4 0.5
Impedance of arm (right) 0.7 3.1 9.4 -3.1 -0.0 -0.2
Arm fat percentage (right) 0.0 0.1 0.2 -0.4 -0.0 0.4
Trunk fat-free mass 0.0 0.1 0.1 -0.3 -0.3 -0.2
Hip circumference 0.1 0.4 0.8 0.5 0.1 0.9
Time employed in main current job 1.5 1.8 3.1 0.5 1.4 1.8
Alcohol intake versus 10 years previously 0.9 1.4 4.0 -0.2 -0.4 -2.0
Father’s age at death 2.1 2.8 4.3 0.5 2.0 2.1
Worrier / anxious feelings 1.1 2.1 5.2 -2.3 -0.6 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.6 0.7 -0.1 0.6
Falls in the last year 0.4 0.5 1.0 -0.7 0.1 -1.0
Hair/balding pattern: Pattern 3 0.2 0.3 0.8 0.9 -0.3 -0.1
Number of live births 0.1 0.1 0.3 -0.3 0.5 0.1
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 2.9 -0.7 -0.7 -1.7
Pulse rate 0.6 1.0 1.6 0.1 1.2 1.3
Happiness 0.5 0.6 1.0 1.0 0.1 0.9
Noisy workplace 3.3 4.0 4.8 -2.2 1.7 2.1
Qualifications: A levels/AS levels or equivalent 0.4 0.9 2.3 0.4 -0.5 -1.5
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 3.4 -0.5 1.9 -0.1
Mouth/teeth dental problems: Dentures 0.2 0.3 0.6 -0.5 -0.8 -0.3
Asthma 0.1 0.3 0.5 0.2 0.7 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.7 1.3 -0.1 1.1
Medication: Cholesterol lowering 0.7 1.1 1.5 -1.2 -1.2 -0.7
Depression (self-reported) 1.7 2.0 5.1 -2.2 -0.7 -0.7
Medication: Lansoprazole 0.9 1.1 1.6 1.3 -0.8 -1.0
Prospective memory result 1.7 2.1 3.9 -0.2 2.0 1.5
Lung cancer (father) 0.4 0.4 0.8 0.9 -0.6 -0.4
Illnesses of mother 0.2 0.2 0.5 0.1 0.3 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 0.8 -0.6 -0.4 -0.9
Pulse wave Arterial Stiffness index 0.7 0.8 1.3 -0.8 -0.6 -1.1
Impedance of arm (left) 1.0 4.6 13.7 -3.7 -0.2 -0.2
Arm fat mass (right) 0.0 0.1 0.1 -0.4 0.0 0.2
Trunk predicted mass 0.0 0.0 0.1 -0.2 -0.3 -0.2
Standing height 0.5 4.6 13.1 -3.6 0.1 -0.9
Length of working week for main job 1.7 1.9 2.4 -1.5 -1.1 -1.6
Exposure to tobacco smoke at home 0.4 0.5 1.0 -1.0 0.6 -0.2
Breastfed as a baby 0.8 0.9 1.8 -0.8 -0.6 -1.4
Tense / ‘highly strung’ 0.6 1.0 1.4 -1.1 -1.2 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.0 3.7 -1.4 -1.9 -0.4
Hair/balding pattern: Pattern 4 0.4 0.9 1.9 -0.9 1.4 0.4
Birth weight of first child 1.2 2.1 3.5 -0.2 1.7 1.9
Peak expiratory flow (PEF) 0.1 0.1 0.2 -0.5 -0.1 -0.4
Pulse wave reflection index 0.4 0.5 0.6 -0.7 -0.8 -0.6
Ever highly irritable/argumentative for 2 days 1.1 1.3 2.2 -1.5 -1.2 -0.5
Loud music exposure frequency 0.7 0.7 1.3 0.9 0.2 1.1
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.7 1.3 0.6 0.8
Mouth/teeth dental problems: Bleeding gums 2.0 2.5 5.3 -1.2 0.9 2.3
Blood clot in the leg (DVT) 0.6 0.8 1.6 0.7 -1.2 0.4
Medication: Paracetamol 1.2 2.0 2.7 -1.0 -1.6 -1.5
Headache pain in last month 1.4 2.4 5.8 1.1 -2.4 -0.3
Medication for cholesterol, blood pressure or diabetes 1.8 2.9 4.5 2.1 1.5 1.4
Glaucoma (self-reported) 0.4 0.4 0.7 -0.6 -0.8 -0.5
Gout (self-reported) 1.6 2.1 3.5 1.9 1.1 1.3
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.4 -0.7 0.7 1.2
Medication: Amlodipine 1.7 2.4 4.9 -2.2 -1.3 -0.9
Medication: Ventolin 100micrograms inhaler 0.3 0.3 0.6 0.3 0.8 0.6
Birth weight 0.8 1.8 3.8 1.2 -0.3 -2.0
Chronic bronchitis/emphysema (mother) 3.0 3.5 6.6 -0.1 2.0 2.6
High blood pressure (siblings) 0.2 0.4 0.5 -0.7 0.6 0.4
Forced vital capacity (FVC), Best measure 0.3 1.2 2.3 -1.1 -0.2 -1.5
Body fat percentage 0.2 0.6 0.9 -0.6 0.8 0.9
Leg fat percentage (right) 0.2 0.8 1.3 0.3 1.1 1.0
Arm fat-free mass (right) 0.0 0.0 0.1 0.3 -0.0 -0.2
Exposure to tobacco smoke outside home 0.5 0.7 1.7 -0.2 0.7 1.3
Comparative body size at age 10 1.6 4.5 12.2 3.5 -1.0 0.4
Number of full brothers 1.3 1.6 2.8 0.6 1.3 1.7
Worry too long after embarrassment 1.4 2.3 4.2 -1.4 -1.0 2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.2 -0.4 -0.1 0.3
Wheeze or whistling in the chest in last year 0.0 0.1 0.2 -0.3 -0.1 -0.4
Number of children fathered 0.3 0.3 0.5 -0.7 -0.6 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 2.3 1.5 -0.0 0.7
Age at first live birth 0.7 1.2 3.3 -0.2 -1.8 -0.5
Pulse wave peak to peak time 0.5 0.5 1.0 0.4 0.7 1.0
Health satisfaction 0.1 0.2 0.3 -0.4 -0.6 -0.2
Shortness of breath walking on level ground 0.7 0.8 1.7 0.9 1.3 0.2
Qualifications: College or University degree 0.3 1.0 1.8 -0.8 -0.6 -1.4
Eye problems/disorders: None of the above 3.5 4.1 4.5 1.9 2.0 2.1
Mouth/teeth dental problems: Loose teeth 0.4 0.4 1.1 -1.1 -0.3 -0.2
Emphysema/chronic bronchitis 1.0 1.1 1.9 -1.0 -1.4 -0.6
Medication for pain relief, constipation, heartburn 0.2 0.4 0.6 0.8 0.8 -0.2
Neck or shoulder pain in last month 0.1 0.1 0.3 0.5 -0.3 -0.2
Medication: Blood pressure 4.1 7.3 12.4 -3.5 -2.1 -2.3
Angina (self-reported) 1.6 2.1 2.7 -1.6 -1.0 -1.6
Migraine (self-reported) 0.7 0.9 2.7 1.6 -0.3 0.0
Medication: Ibuprofen 0.2 0.3 0.4 0.6 -0.3 0.6
Medication: Allopurinol 0.2 0.3 0.9 0.9 -0.0 -0.2
Medication: Omeprazole 1.4 1.6 2.8 0.5 1.4 1.7
Medication: Seretide 50 evohaler 2.8 3.2 5.7 -0.7 -1.9 -2.4
Mean time to correctly identify matches 0.4 0.7 0.8 0.9 0.8 0.8
Heart disease (mother) 0.4 0.5 0.7 -0.7 -0.8 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 5.5 2.4 0.1 0.2
Whole body fat mass 0.1 0.3 0.4 -0.5 0.5 0.7
Leg fat mass (right) 0.0 0.1 0.2 0.0 0.4 0.4
Arm predicted mass (right) 0.0 0.1 0.1 0.1 -0.2 -0.3
Pulse rate, automated reading 1.0 3.2 6.8 0.7 2.6 1.5
Alcohol intake frequency. 1.0 2.4 5.5 2.3 -0.4 1.2
Comparative height size at age 10 0.6 3.2 7.5 -2.7 1.4 -0.0
Number of full sisters 3.7 4.5 7.7 1.3 2.0 2.8
Suffer from ‘nerves’ 0.0 0.0 0.0 -0.1 0.0 -0.1
Overall health rating 0.6 1.3 2.9 0.0 -0.9 -1.7
Chest pain or discomfort 0.2 0.3 0.6 -0.5 0.1 -0.8
Had major operations 0.1 0.1 0.4 0.1 0.6 -0.0
Age at last live birth 3.3 4.8 8.6 -0.5 -2.9 -2.3
Family relationship satisfaction 0.2 0.2 0.3 -0.5 -0.5 -0.5
Leg pain on walking 0.5 0.6 1.2 1.1 0.6 0.4
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 2.1 1.3 -0.2 1.5
Commuting to job workplace: Car/motor vehicle 0.9 1.1 2.2 1.5 -0.4 -1.0
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.7 0.1 -0.9 0.3
Medication: Aspirin 0.7 1.0 2.1 -0.5 -1.4 -0.7
Supplements: Vitamin C 0.7 0.9 1.1 -0.7 -1.0 -1.0
Knee pain experienced in last month 0.3 0.5 1.4 -0.4 1.2 0.1
Hypertension (Self-reported) 3.5 9.8 19.6 -4.4 -2.1 -2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 2.8 -1.7 0.6 0.1
Illnesses of father: Heart disease 1.3 1.8 3.7 -0.8 -1.1 -1.9
Illnesses of siblings: Diabetes 0.4 0.5 0.8 0.6 0.9 0.4
Smoking status: Previous 0.5 0.8 2.0 1.4 0.4 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 3.1 0.2 1.0 1.8
Whole body fat-free mass 0.0 0.1 0.4 -0.1 -0.6 -0.1
Leg fat-free mass (right) 0.1 0.3 0.9 0.1 -0.9 -0.1
Arm fat percentage (left) 0.0 0.2 0.4 -0.6 0.1 0.4
Average weekly red wine intake 0.2 0.3 0.6 0.2 -0.3 0.8
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.8 0.6 -0.1 -0.9
Mood swings 0.8 1.5 2.9 -1.7 -1.2 -0.4
Loneliness, isolation 0.3 0.4 0.9 -0.5 -0.9 0.5
Long-standing illness, disability or infirmity 0.5 0.8 1.3 0.8 1.2 0.6
Ever had bowel cancer screening 0.6 0.7 1.0 1.0 0.9 -0.6
Diabetes diagnosed by doctor 0.7 1.2 3.6 1.9 0.1 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 2.3 1.2 1.5 0.6
Friendships satisfaction 0.2 0.2 0.5 -0.1 -0.4 0.7
Qualifications: nursing, teaching 0.3 0.5 0.7 0.7 0.8 0.6
Commuting to job workplace: Walk 2.3 2.5 6.5 2.5 0.6 0.7
Eye problems/disorders: Cataract 2.0 2.3 2.9 -1.7 -1.6 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 0.6 -0.3 0.8 0.8
Medication for cholesterol 0.5 0.7 1.8 1.3 -0.1 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.1 0.1 0.0 -0.4 0.2
Back pain experienced in last month 0.3 0.5 0.5 0.7 -0.7 -0.7
Mineral and other dietary supplements 1.2 1.5 2.8 -1.7 1.2 0.6
Breast cancer (self-reported) 0.2 0.2 0.3 -0.5 -0.5 -0.3
Asthma (self-reported) 0.2 0.3 0.7 0.4 0.8 0.3
Osteoporosis (self-reported) 1.5 1.8 3.4 1.8 1.4 0.4
Osteoarthritis (self-reported) 0.2 0.2 0.2 0.5 -0.5 -0.3
Medication: Aspirin 0.6 0.8 1.6 -0.7 -1.2 -0.6
Medication: Gliclazide 0.2 0.2 0.5 0.2 -0.7 -0.2
Illnesses of father: None of the above (group 1) 0.6 0.7 1.1 1.1 -1.0 -0.0
Smoking status: Current 0.9 1.4 1.9 -1.1 -1.4 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 1.8 -1.4 -0.9 -0.4
Whole body water mass 0.0 0.1 0.2 -0.0 -0.5 -0.2
Leg predicted mass (right) 0.1 0.3 0.8 0.2 -0.9 0.0
Arm fat mass (left) 0.0 0.1 0.2 -0.4 0.1 0.3
Number of self-reported non-cancer illnesses 0.1 0.2 0.4 0.6 0.2 0.4
Average weekly champagne plus white wine intake 0.0 0.1 0.1 -0.4 0.2 0.0
Miserableness 0.3 0.5 1.3 -1.1 -0.5 -0.0
Guilty feelings 0.6 1.0 1.8 -1.3 -0.8 -0.7
Wears glasses or contact lenses 0.4 0.4 0.8 0.1 0.7 0.9
Ever taken oral contraceptive pill 0.2 0.2 0.5 -0.3 0.7 0.3
Hearing aid user 2.8 3.1 7.7 -2.8 -0.8 -1.0
Mother’s age at death 0.8 0.9 2.0 -1.4 0.9 -0.0
Financial situation satisfaction 0.2 0.3 0.7 0.8 -0.3 -0.0
Tinnitus: Yes, now most or all of the time 0.6 0.6 0.8 -0.8 0.9 0.7
Commuting to job workplace: Public transport 1.6 1.9 3.8 -0.9 1.1 1.9
Eye problems/disorders: Glaucoma 1.0 1.2 1.7 -1.1 -1.3 -0.9
Medication: Blood pressure 1.4 2.7 3.6 -1.9 -1.0 -1.9
Pain type(s) experienced in last month: Hip pain 2.2 2.7 7.1 2.7 0.3 1.0
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.3 0.4 -0.6 -0.1
High cholesterol (Self-reported) 0.7 1.2 3.0 -1.7 -0.7 0.3
Medication: Bendroflumethiazide 0.3 0.5 0.9 -1.0 -0.1 -0.7
Medication: Paracetamol 0.4 0.7 1.0 -0.7 -0.8 -1.0
Medication: Lisinopril 1.4 1.8 3.3 -1.8 -0.4 -1.4
Medication: Atorvastatin 0.5 0.6 1.5 -0.5 -1.2 -0.2
Illnesses of father: High blood pressure 0.6 0.8 1.7 -1.3 0.7 -0.5
Alcohol drinker status: Never 0.5 0.6 1.0 0.2 0.9 1.0
Ever smoked 0.1 0.1 0.4 0.3 -0.0 -0.6
Basal metabolic rate 0.0 0.1 0.2 -0.1 -0.5 -0.2
Leg fat percentage (left) 0.3 1.1 2.0 0.6 1.4 0.9
Arm fat-free mass (left) 0.0 0.2 0.5 0.7 0.3 0.1
Number of operations (self-reported) 0.2 0.2 0.7 0.2 0.8 -0.0
Average weekly beer plus cider intake 1.0 1.5 3.5 -0.8 -0.5 -1.9
Irritability 0.5 0.9 2.4 -1.6 0.5 -0.0
Risk taking 0.3 0.5 0.8 0.3 0.9 -0.8
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.6 -0.0 0.8 -0.1
Fractured/broken bones in last 5 years 0.2 0.2 0.5 0.3 -0.7 -0.2
Age started oral contraceptive pill 0.3 0.4 1.0 -0.4 0.3 -1.0
Diastolic blood pressure, automated reading 2.2 6.8 10.2 -3.2 -2.3 -2.3
Ever depressed for a whole week 1.8 2.2 5.3 2.3 -0.9 -0.7
Unable to work because of sickness or disability 0.1 0.1 0.1 0.3 0.3 -0.3
Commuting to job workplace: Cycle 0.1 0.1 0.3 -0.5 -0.3 -0.2
Myopia 0.4 0.5 1.2 -0.4 -0.5 -1.1
Vascular/heart problems diagnosed by doctor 5.0 13.7 24.9 5.0 2.5 3.2
Cholesterol lowering medication 0.5 0.7 1.8 -1.4 0.3 0.3
Medication: Omeprazole (e.g. Zanprol) 2.0 2.4 3.6 0.5 1.9 1.9
Pain experienced in last month 0.1 0.1 0.2 -0.5 -0.1 0.3
Supplements: Calcium 1.0 1.1 2.9 1.7 -0.6 -0.1
Basal cell carcinoma (self-reported) 0.7 0.8 1.5 -1.2 -0.2 -0.9
Heart attack/myocardial infarction (self-reported) 2.9 3.8 6.4 -0.5 -2.1 -2.5
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 2.0 0.4 -1.4 0.1
Heart disease (siblings) 1.6 2.0 2.8 1.7 1.6 0.7
Alcohol drinker status: Previous 0.5 0.6 0.8 0.6 -0.9 0.7
Pack years of smoking 2.4 3.5 4.6 -2.0 -2.1 -1.4
Impedance of whole body 0.7 3.4 9.9 -3.1 0.4 -0.3
Leg fat mass (left) 0.1 0.2 0.4 0.3 0.7 0.4
Arm predicted mass (left) 0.0 0.0 0.0 0.2 -0.0 -0.1