Hub : Genes

POLN

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0470 0.018 0.00032 0.051 0.021 0.040 0.039 0.041 7.0e-07 0.0011 1.2e-05 1.2e-05 8.6e-06
2 GTEx Testis 0.1430 0.059 0.00350 0.016 NA 0.007 NA 0.033 6.4e-02 NA 1.6e-01 NA 1.3e-02
3 TCGA Lung Squamous Cell Carcinoma 0.0186 0.012 0.00550 0.005 0.011 0.004 NA 0.004 7.9e-02 0.0190 1.0e-01 NA 9.5e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.8 2.9 4.4 -2.1 -0.3 2.1
Bipolar Disorder or Schizophrenia 1.1 2.7 5.5 -1.6 0.3 2.3
Depressed Affect (Nagel 2018) 0.0 0.1 0.2 0.5 0.2 -0.1
Depression (Nagel 2018) 0.6 0.9 2.5 -0.2 1.6 0.3
Intelligence (Savage-Jansen 2018) 1.2 3.8 5.8 -2.3 2.4 0.7
Neuroticism (Nagel 2018) 0.0 0.1 0.1 -0.2 0.4 0.2
Schizophrenia (2018) 0.4 0.8 1.7 -0.3 0.7 1.3
Schizophrenia vs Biploar Disorder 0.3 0.4 0.5 -0.4 0.7 0.7
Worry (Nagel 2018) 0.1 0.2 0.5 0.1 0.7 -0.1
Alzheimer’s Disease (in mother) 0.5 0.6 1.6 -0.1 -1.3 0.3
Alzheimer’s Disease (in father) 1.2 1.3 1.8 -1.3 0.6 1.4
Alzheimer’s Disease (including proxy) 0.1 0.1 0.1 -0.2 -0.4 0.4
Crohns Disease (2017) 0.4 1.0 1.2 -0.9 1.1 1.0
Irritable Bowel Disease (IBD) 0.3 0.6 1.5 0.4 1.2 0.5
Ulcerative Colitis (UC) 0.5 1.0 1.5 1.2 1.2 0.0
Major Depression (MDD) 0.8 1.0 1.5 0.9 0.7 -1.2
Reaction Time 1.2 2.3 3.8 -1.3 -1.2 2.0
Verbal and Numeric Reasoning (VNR) 1.2 2.9 4.2 -2.1 1.6 1.4
Breast Cancer 0.0 0.1 0.2 0.3 -0.0 -0.4
Ovarian Cancer 0.8 1.1 2.6 -1.6 -0.7 0.3
Prostate Cancer 0.7 1.0 3.0 0.0 1.7 0.3
Age at First Birth 0.7 1.0 2.1 -0.9 -0.4 1.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 4.8 6.6 12.0 1.8 -3.5 -2.1
Coronary Artery Disease (CAD) 0.2 0.3 0.8 -0.9 -0.1 0.1
Crohns Disease (2012) 1.6 2.6 3.3 -1.7 1.3 1.8
Mean Putamen Volume 0.7 0.8 1.5 -0.8 0.5 1.2
Fasting Glucose 0.2 0.2 0.3 -0.5 0.4 0.5
HbA1C 1.5 1.7 2.8 -1.7 1.5 0.3
HDL Cholesterol 2.0 3.3 5.1 -1.5 1.5 2.3
LDL Cholesterol 0.1 0.2 0.4 -0.2 0.4 -0.6
Lupus 4.7 7.2 10.9 -3.3 0.5 3.2
Neuroticism (2016) 0.2 0.3 0.6 -0.8 0.5 0.0
Primary Biliary Cirrhosis 1.8 2.6 3.7 -1.5 1.3 1.9
Rheumatoid Arthritis 0.2 0.3 0.5 0.4 -0.7 0.4
Schizophrenia (2014) 0.3 0.6 1.6 -0.3 0.3 1.3
Triglycerides 0.4 0.7 1.6 0.6 0.3 -1.2
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.0 -1.0 -0.9 1.0
Ulcerative Colitis 0.6 0.8 1.8 1.4 0.7 -0.2
Blood Eosinophil Count 0.5 3.6 8.2 -0.9 2.9 1.3
Blood Platelet Count 0.1 1.2 3.4 0.1 0.4 1.8
Blood Red Count 0.2 2.2 5.4 -0.5 2.3 0.9
Blood White Count 1.3 10.0 14.0 -3.7 2.5 3.1
Heel T-Score 0.7 5.8 10.0 -2.7 -0.2 3.2
BMI 1.9 10.9 15.4 3.9 -2.2 -3.5
Height 1.7 33.1 54.0 4.7 -4.8 -7.3
Waist Hip Ratio (WHR) 0.8 3.5 10.3 -0.4 3.2 0.0
Systolic Blood Pressure 4.1 20.6 30.2 -5.5 1.9 5.3
Smoking Status 0.2 0.5 1.2 -0.6 1.1 0.1
Allergy or Eczema 0.3 0.9 1.1 1.0 0.6 -1.1
Cardiovascular Disease 0.4 1.5 2.4 -1.5 -0.4 1.4
Hypothyroidism (self reported) 0.2 0.4 1.1 0.1 1.1 0.4
Respiratory disease 0.4 0.8 2.1 0.1 1.4 -0.5
Type 2 Diabetes (T2D) (2018) 1.9 3.5 10.1 -0.7 3.2 0.1
Lung FEV1/FVC ratio 0.2 1.2 1.8 -1.1 -0.8 1.3
Lung FVC 0.3 1.7 2.2 -0.9 1.5 1.4
Neuroticism 0.1 0.1 0.4 -0.1 0.6 0.1
Chronotype (morning person) 0.9 2.1 4.6 2.1 -0.5 -1.2
Hair Pigment 0.0 1.4 2.6 -1.6 0.2 1.2
Tanning 0.1 0.7 1.9 0.4 -1.4 0.1
Hand grip strength (left) 0.9 2.5 4.6 1.5 -0.7 -2.1
Number of treatments/medications taken 0.4 0.8 1.8 0.5 0.6 -1.3
Average weekly spirits intake 4.8 6.0 10.0 -2.8 0.5 3.2
Sensitivity / hurt feelings 0.1 0.1 0.2 0.5 -0.1 -0.4
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.3 0.1 0.5 0.2
Hearing difficulty/problems: Yes 1.2 1.8 2.7 1.6 -0.5 -1.6
Relative age of first facial hair 1.0 2.0 3.9 -2.0 -1.1 0.9
Other serious medical condition/disability diagnosed by doctor 1.5 2.0 3.3 -1.5 0.8 1.8
Ever used hormone-replacement therapy (HRT) 2.2 2.8 3.1 -1.7 1.6 1.8
Ever had hysterectomy (womb removed) 1.5 1.7 3.4 1.8 0.5 -1.2
Systolic blood pressure, automated reading 2.9 8.5 13.3 -3.6 0.5 3.5
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.5 -0.4 0.3 -0.7
Angina 0.5 0.7 1.6 -0.6 1.3 0.2
Medication for hormone replacement therapy 0.4 0.4 0.6 0.8 0.2 -0.8
Vitamin and mineral supplements 0.5 0.6 1.5 0.0 -1.2 0.6
Supplements: Zinc 1.3 1.4 2.8 1.7 0.6 -1.0
Medication: Co-codamol 1.1 1.3 2.7 0.4 1.6 -1.0
Medication: Metformin 0.8 1.1 2.9 -0.2 1.7 -0.6
Diabetes (father) 0.4 0.5 0.7 -0.1 -0.9 -0.8
Diabetes (mother) 0.3 0.4 0.9 -0.9 -0.1 0.5
Severe depression (siblings) 0.4 0.5 1.3 -0.3 0.3 1.2
Pack years adult smoking proportion 0.5 0.8 2.1 0.4 -1.5 -0.5
Impedance of leg (right) 1.1 5.5 6.0 -2.4 2.4 2.1
Leg fat-free mass (left) 2.7 14.3 18.7 3.5 -3.4 -4.3
Trunk fat percentage 2.1 8.4 11.9 2.8 -2.3 -3.4
Hand grip strength (right) 1.4 3.7 5.2 2.2 -1.1 -2.3
Townsend deprivation index at recruitment 0.3 0.4 1.1 0.4 1.0 0.4
Current tobacco smoking 0.3 0.5 1.2 -1.1 0.2 0.6
Average weekly fortified wine intake 1.5 1.7 3.1 -1.8 -0.1 1.4
Maternal smoking around birth 0.5 0.7 1.8 -1.3 -0.2 0.7
Fed-up feelings 0.3 0.6 0.9 -1.0 0.6 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 4.4 -0.9 2.1 0.9
Relative age voice broke 0.4 0.6 1.0 -1.0 -0.8 -0.0
Taking other prescription medications 0.2 0.3 0.8 0.3 0.9 -0.4
Age when periods started (menarche) 0.3 0.7 1.2 -0.3 -1.1 -0.9
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.5 0.7 -0.2 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.5 0.7 -0.3 -0.5
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 1.7 1.0 0.4 -1.3
Qualifications: CSEs or equivalent 0.4 0.6 0.9 0.0 0.9 0.9
Serious illness, injury or assault to yourself 0.8 1.0 2.7 -0.5 0.3 1.6
High blood pressure 0.2 0.5 0.9 -0.9 -0.5 0.5
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.8 -0.3 0.9 -0.3
Multivitamins +/- minerals 0.0 0.0 0.1 -0.1 0.1 -0.3
Stomach or abdominal pain in last month 0.2 0.2 0.6 0.7 0.1 -0.3
Supplements: Glucosamine 0.7 1.0 2.0 -1.4 0.3 0.9
Diverticular disease/diverticulitis (self-reported) 1.3 1.6 3.0 1.7 -0.1 -1.3
Medication: Atenolol 0.5 0.6 1.7 -0.2 1.3 -0.3
Medication: Levothyroxine sodium 0.1 0.1 0.2 0.5 -0.3 0.0
Sitting height 1.2 8.7 15.2 2.1 -2.5 -3.9
Chronic bronchitis/emphysema (father) 1.9 2.2 4.0 2.0 -0.7 -1.5
High blood pressure (mother) 3.1 4.4 8.9 -1.9 3.0 0.7
Body mass index (BMI) 2.7 11.5 14.3 3.7 -2.6 -3.8
Impedance of leg (left) 1.3 6.4 7.8 -2.4 2.8 2.4
Leg predicted mass (left) 2.7 14.2 18.4 3.5 -3.4 -4.3
Trunk fat mass 3.0 12.9 18.9 3.4 -2.9 -4.3
Waist circumference 1.5 5.4 9.9 2.2 -1.3 -3.1
Number of incorrect matches in round 0.3 0.5 1.4 0.5 1.2 -0.1
Past tobacco smoking 0.0 0.1 0.1 -0.1 -0.3 0.3
Alcohol usually taken with meals 0.7 1.1 3.2 -0.5 1.8 0.1
Nervous feelings 0.0 0.0 0.1 0.3 0.1 -0.1
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 7.1 0.3 2.7 -0.5
Hearing difficulty/problems with background noise 0.5 0.8 1.4 0.6 0.8 -1.2
Hair/balding pattern: Pattern 2 0.4 0.5 1.4 -0.2 1.2 0.1
Had menopause 3.5 4.4 7.5 -2.0 1.2 2.7
Had other major operations 1.1 1.4 3.3 0.8 0.4 -1.8
Forced vital capacity (FVC) 0.2 0.8 1.1 0.6 -1.0 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.3 0.4 -0.3 -0.5
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 1.3 -0.1 1.1 -0.1
Qualifications: None of the above 0.1 0.3 0.6 0.8 -0.1 -0.4
Financial difficulties in last 2 years 0.6 0.8 1.7 -0.9 -0.1 1.3
Mouth/teeth dental problems 0.2 0.4 0.9 -0.1 1.0 0.4
Heart attack 0.3 0.3 0.8 0.4 0.9 -0.2
Allergy 0.1 0.3 0.7 0.0 -0.8 0.4
Pain all over the body in last month 0.2 0.2 0.5 0.0 0.7 0.1
Diabetes (self-reported) 1.5 2.3 6.6 -0.3 2.6 -0.3
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.7 -0.5 0.8 -0.3
Medication: Ramipril 0.1 0.2 0.4 0.3 -0.2 -0.6
Medication: Simvastatin 0.6 0.9 1.6 0.4 1.3 -1.0
Fluid intelligence score 1.1 2.3 3.0 -1.7 1.1 1.6
Illnesses of siblings 0.0 0.0 0.1 -0.1 -0.3 0.2
Neuroticism score 0.4 0.8 1.1 -0.8 1.1 0.7
Weight 3.5 17.0 24.5 4.0 -3.2 -5.0
Impedance of arm (right) 0.8 3.6 5.6 -2.4 0.7 2.2
Arm fat percentage (right) 2.3 9.2 9.7 2.9 -3.1 -3.1
Trunk fat-free mass 1.7 10.0 15.0 2.9 -2.5 -3.9
Hip circumference 2.1 9.2 11.7 2.7 -2.9 -3.4
Time employed in main current job 0.6 0.7 1.1 0.9 -0.4 -1.0
Alcohol intake versus 10 years previously 5.6 8.4 14.0 3.7 -1.4 -3.0
Father’s age at death 0.3 0.4 1.1 0.4 -1.0 0.1
Worrier / anxious feelings 0.5 0.9 2.3 -0.4 1.5 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.8 0.1 1.3 -0.3
Falls in the last year 1.2 1.6 3.2 1.3 -0.1 -1.8
Hair/balding pattern: Pattern 3 0.5 0.7 1.2 -1.1 -0.1 1.0
Number of live births 0.7 0.9 1.4 1.2 -0.5 -1.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 0.5 0.6 -0.6 -0.7
Pulse rate 2.3 3.9 5.6 -1.9 2.4 1.6
Happiness 1.0 1.2 1.8 1.3 -0.4 -1.2
Noisy workplace 0.8 0.9 1.6 0.8 0.7 -1.3
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.8 -0.9 0.1 0.3
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 2.2 -1.4 1.5 0.6
Mouth/teeth dental problems: Dentures 0.3 0.5 1.3 -0.1 -1.2 0.2
Asthma 0.4 0.7 1.0 1.0 0.4 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.3 0.5 -0.1 -1.1
Medication: Cholesterol lowering 0.8 1.3 2.5 1.1 0.3 -1.6
Depression (self-reported) 0.0 0.1 0.1 -0.3 -0.3 -0.0
Medication: Lansoprazole 0.1 0.1 0.2 0.4 0.0 -0.5
Prospective memory result 0.8 1.0 2.2 0.4 -1.5 -0.8
Lung cancer (father) 0.6 0.7 1.6 0.5 -1.3 -0.5
Illnesses of mother 2.7 3.4 8.1 2.9 -1.0 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.0 0.0 -0.0 0.2 -0.2
Pulse wave Arterial Stiffness index 0.1 0.1 0.4 -0.2 0.6 -0.1
Impedance of arm (left) 0.7 3.1 4.8 -2.2 0.6 2.0
Arm fat mass (right) 3.1 12.9 16.1 3.4 -3.3 -4.0
Trunk predicted mass 1.7 9.8 14.5 2.9 -2.5 -3.8
Standing height 0.5 5.2 10.4 1.3 -1.8 -3.2
Length of working week for main job 0.5 0.6 1.5 -0.4 1.2 -0.2
Exposure to tobacco smoke at home 0.6 0.7 1.2 -1.1 -0.0 0.9
Breastfed as a baby 1.3 1.6 1.8 -1.2 -1.3 1.2
Tense / ‘highly strung’ 0.6 1.1 1.6 0.4 1.2 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.2 0.2 0.0 -0.5
Hair/balding pattern: Pattern 4 0.5 1.3 3.7 0.4 -1.9 -0.1
Birth weight of first child 0.2 0.4 1.0 0.1 1.0 -0.6
Peak expiratory flow (PEF) 1.0 2.4 4.4 1.0 1.3 -2.1
Pulse wave reflection index 1.4 1.8 3.6 0.9 -1.9 -1.0
Ever highly irritable/argumentative for 2 days 2.1 2.6 7.0 0.2 2.6 -0.8
Loud music exposure frequency 1.3 1.4 3.7 0.1 1.9 -0.7
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 1.5 -1.1 0.6 1.2
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.6 -1.3 0.0 0.9
Blood clot in the leg (DVT) 2.8 3.6 7.1 1.8 -2.7 -0.6
Medication: Paracetamol 0.4 0.6 0.9 0.6 0.8 -1.0
Headache pain in last month 0.9 1.5 2.0 1.4 1.4 -0.8
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 2.2 -1.2 1.1 1.5
Glaucoma (self-reported) 2.3 2.7 4.1 -2.0 -0.2 2.0
Gout (self-reported) 0.1 0.1 0.4 0.0 0.1 0.6
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.1 -0.3 0.3 0.4
Medication: Amlodipine 0.9 1.2 2.9 -0.8 -1.7 0.5
Medication: Ventolin 100micrograms inhaler 1.5 2.0 4.1 1.3 0.3 -2.0
Birth weight 0.8 1.8 3.3 0.9 -1.2 -1.8
Chronic bronchitis/emphysema (mother) 1.2 1.4 2.4 -1.3 0.3 1.5
High blood pressure (siblings) 0.1 0.1 0.2 -0.5 0.2 0.1
Forced vital capacity (FVC), Best measure 0.1 0.3 0.8 0.3 -0.1 -0.9
Body fat percentage 2.0 7.7 10.8 2.8 -2.2 -3.3
Leg fat percentage (right) 1.8 6.6 10.1 2.7 -1.5 -3.2
Arm fat-free mass (right) 2.2 11.5 18.1 3.3 -2.4 -4.3
Exposure to tobacco smoke outside home 2.8 3.7 7.4 1.9 0.4 -2.7
Comparative body size at age 10 0.1 0.2 0.2 0.4 -0.5 -0.3
Number of full brothers 0.8 1.0 2.1 1.4 -0.0 -1.0
Worry too long after embarrassment 0.2 0.3 0.7 -0.8 0.3 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.4 0.6 -0.6 -0.1
Wheeze or whistling in the chest in last year 1.2 2.2 2.9 1.6 1.0 -1.7
Number of children fathered 1.4 1.6 3.4 0.6 -1.0 -1.8
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.8 4.7 0.8 2.2 -0.4
Age at first live birth 0.1 0.2 0.4 -0.4 -0.6 0.3
Pulse wave peak to peak time 0.2 0.2 0.6 0.3 -0.8 -0.1
Health satisfaction 0.2 0.3 0.6 -0.6 0.8 0.0
Shortness of breath walking on level ground 0.1 0.1 0.2 -0.4 -0.4 0.2
Qualifications: College or University degree 0.2 0.5 1.4 -1.2 -0.4 -0.1
Eye problems/disorders: None of the above 0.2 0.3 0.4 0.6 0.2 -0.6
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.9 -0.1 -1.4 0.1
Emphysema/chronic bronchitis 0.2 0.3 0.5 -0.5 0.7 0.2
Medication for pain relief, constipation, heartburn 0.5 0.9 1.9 0.2 -0.9 1.4
Neck or shoulder pain in last month 0.4 0.6 1.6 0.3 -0.2 -1.3
Medication: Blood pressure 0.9 1.5 3.3 0.7 -1.8 -0.8
Angina (self-reported) 0.4 0.5 1.3 -0.4 1.1 0.1
Migraine (self-reported) 0.1 0.1 0.2 0.4 0.1 0.2
Medication: Ibuprofen 0.2 0.3 0.6 0.2 0.4 -0.8
Medication: Allopurinol 0.5 0.7 1.1 -1.0 0.4 0.9
Medication: Omeprazole 0.1 0.1 0.2 -0.1 0.5 0.3
Medication: Seretide 50 evohaler 0.2 0.2 0.3 0.4 0.6 -0.2
Mean time to correctly identify matches 1.8 3.5 5.7 -1.8 -1.2 2.4
Heart disease (mother) 3.5 4.3 9.6 -3.1 1.2 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.3 0.9 -0.6 -1.1
Whole body fat mass 3.0 12.7 17.9 3.5 -2.8 -4.2
Leg fat mass (right) 2.9 11.2 16.3 3.4 -2.5 -4.0
Arm predicted mass (right) 2.1 10.7 17.1 3.2 -2.2 -4.1
Pulse rate, automated reading 1.5 5.0 7.1 -2.3 2.7 1.7
Alcohol intake frequency. 1.4 3.2 6.4 2.5 -0.2 -1.8
Comparative height size at age 10 0.6 3.2 5.3 1.9 -0.9 -2.3
Number of full sisters 0.6 0.7 1.9 -0.2 1.4 0.3
Suffer from ‘nerves’ 0.0 0.0 0.1 -0.2 -0.0 0.1
Overall health rating 0.5 1.1 1.6 0.9 -1.0 -1.3
Chest pain or discomfort 0.3 0.4 0.9 -0.4 0.9 -0.4
Had major operations 0.9 1.0 2.8 -0.2 -1.7 0.5
Age at last live birth 0.4 0.6 1.8 0.3 -1.3 -0.2
Family relationship satisfaction 2.5 3.1 3.5 1.8 -1.6 -1.9
Leg pain on walking 0.5 0.7 1.0 0.9 0.4 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.3 0.3 0.6 -0.4
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.0 1.0 -0.6 -0.9
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 2.4 1.5 0.1 -1.6
Medication: Aspirin 0.2 0.3 0.7 -0.9 -0.1 -0.3
Supplements: Vitamin C 0.3 0.3 0.7 -0.5 0.9 -0.0
Knee pain experienced in last month 0.5 0.8 1.2 -0.9 -0.6 1.1
Hypertension (Self-reported) 0.2 0.6 1.0 -1.0 -0.7 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.1 0.8 -0.3 -1.0
Illnesses of father: Heart disease 0.5 0.7 1.3 -0.7 1.1 0.6
Illnesses of siblings: Diabetes 0.4 0.5 0.8 0.4 0.9 -0.7
Smoking status: Previous 0.3 0.5 0.9 0.6 0.4 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.4 0.1 0.6 -0.6
Whole body fat-free mass 2.1 12.1 16.6 3.2 -3.0 -4.1
Leg fat-free mass (right) 2.4 12.8 16.3 3.5 -3.2 -4.0
Arm fat percentage (left) 2.5 10.1 10.8 3.1 -3.2 -3.3
Average weekly red wine intake 2.4 3.6 7.1 -2.7 1.5 1.2
Handedness (chirality/laterality): Left-handed 1.1 1.4 3.7 0.2 -1.9 0.6
Mood swings 0.0 0.0 0.1 0.1 0.3 -0.1
Loneliness, isolation 0.8 1.1 2.0 1.4 0.7 -0.9
Long-standing illness, disability or infirmity 1.6 2.4 3.8 1.6 0.8 -2.0
Ever had bowel cancer screening 0.3 0.3 0.5 0.4 -0.5 -0.7
Diabetes diagnosed by doctor 1.1 1.8 4.8 -0.7 2.2 0.0
Ever had stillbirth, spontaneous miscarriage or termination 2.5 2.6 2.7 1.6 1.6 -1.6
Friendships satisfaction 1.5 1.9 2.6 1.5 -1.6 -1.0
Qualifications: nursing, teaching 0.2 0.3 0.7 0.1 0.5 -0.9
Commuting to job workplace: Walk 3.0 3.2 4.4 -1.4 2.1 1.8
Eye problems/disorders: Cataract 2.0 2.3 4.2 -1.6 -0.2 2.0
Mouth/teeth dental problems: Mouth ulcers 2.2 3.5 5.5 1.2 2.3 -1.9
Medication for cholesterol 0.5 0.7 1.1 1.0 0.3 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 0.8 0.8 -0.2 -0.9
Back pain experienced in last month 1.6 2.4 3.3 1.4 -1.8 -1.3
Mineral and other dietary supplements 0.2 0.3 0.5 0.5 0.7 -0.4
Breast cancer (self-reported) 1.9 2.3 3.8 2.0 0.1 -1.7
Asthma (self-reported) 0.6 1.1 1.8 1.3 0.3 -1.2
Osteoporosis (self-reported) 1.3 1.6 2.3 -1.5 0.8 1.4
Osteoarthritis (self-reported) 0.0 0.1 0.2 0.1 -0.0 0.4
Medication: Aspirin 0.2 0.2 0.5 -0.7 -0.4 -0.2
Medication: Gliclazide 1.1 1.3 3.7 -0.2 1.9 -0.3
Illnesses of father: None of the above (group 1) 0.2 0.2 0.5 0.2 -0.7 0.3
Smoking status: Current 0.4 0.7 1.4 -1.2 0.1 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.8 6.0 7.4 -2.3 2.7 2.3
Whole body water mass 2.2 12.3 17.0 3.3 -3.1 -4.1
Leg predicted mass (right) 2.5 13.3 16.8 3.5 -3.2 -4.1
Arm fat mass (left) 3.3 13.7 17.6 3.6 -3.3 -4.2
Number of self-reported non-cancer illnesses 0.4 0.7 1.4 0.5 1.2 -0.7
Average weekly champagne plus white wine intake 0.1 0.1 0.2 -0.4 -0.4 0.2
Miserableness 0.6 1.1 1.2 -1.1 1.0 1.0
Guilty feelings 0.4 0.6 1.0 -0.9 0.1 1.0
Wears glasses or contact lenses 0.3 0.4 0.8 -0.9 -0.3 0.5
Ever taken oral contraceptive pill 1.5 1.7 4.6 0.7 -2.1 0.3
Hearing aid user 0.5 0.5 0.9 0.8 0.1 -1.0
Mother’s age at death 0.3 0.3 0.9 -0.3 0.9 0.1
Financial situation satisfaction 0.0 0.0 0.0 0.1 -0.1 0.0
Tinnitus: Yes, now most or all of the time 1.0 1.2 1.3 -1.1 1.0 1.1
Commuting to job workplace: Public transport 0.4 0.5 1.2 -0.1 -1.1 0.4
Eye problems/disorders: Glaucoma 0.6 0.7 0.9 -0.7 -0.7 0.9
Medication: Blood pressure 1.9 3.7 6.4 -2.5 -0.1 2.1
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.2 -0.0 -0.4 -0.4
Supplements: Fish oil (including cod liver oil) 1.3 1.7 3.2 -1.8 -0.1 1.4
High cholesterol (Self-reported) 0.5 0.9 1.3 1.1 -0.1 -1.2
Medication: Bendroflumethiazide 0.3 0.5 0.8 -0.9 -0.7 -0.5
Medication: Paracetamol 0.2 0.3 0.7 0.1 0.8 -0.6
Medication: Lisinopril 1.3 1.7 2.8 -1.1 -1.7 1.1
Medication: Atorvastatin 0.1 0.2 0.4 -0.2 0.6 -0.2
Illnesses of father: High blood pressure 1.4 1.8 2.6 -1.5 0.6 1.6
Alcohol drinker status: Never 0.7 0.8 1.2 1.1 -0.4 -1.1
Ever smoked 0.1 0.1 0.1 -0.4 -0.4 0.3
Basal metabolic rate 2.7 14.7 20.2 3.7 -3.2 -4.5
Leg fat percentage (left) 2.1 7.6 11.2 3.1 -1.4 -3.4
Arm fat-free mass (left) 2.3 11.6 17.1 3.4 -2.5 -4.1
Number of operations (self-reported) 0.2 0.3 0.7 -0.1 -0.9 -0.1
Average weekly beer plus cider intake 2.0 3.0 4.9 1.8 -0.9 -2.2
Irritability 2.4 4.1 6.0 -1.9 2.5 1.6
Risk taking 0.1 0.1 0.4 0.3 0.0 -0.6
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.5 0.1 -1.6 -0.4
Fractured/broken bones in last 5 years 0.1 0.2 0.3 0.6 -0.3 -0.4
Age started oral contraceptive pill 0.6 0.7 1.0 -0.8 0.7 1.0
Diastolic blood pressure, automated reading 3.2 10.1 14.1 -3.8 2.2 3.3
Ever depressed for a whole week 1.4 1.7 2.6 1.6 -0.7 -1.4
Unable to work because of sickness or disability 0.3 0.4 1.0 1.0 -0.2 -0.4
Commuting to job workplace: Cycle 0.2 0.3 0.4 0.6 -0.4 -0.5
Myopia 0.6 0.8 1.1 -1.1 0.6 1.0
Vascular/heart problems diagnosed by doctor 0.1 0.1 0.3 0.4 0.5 0.0
Cholesterol lowering medication 0.1 0.2 0.2 0.5 -0.4 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.1 0.0 0.2 0.3
Pain experienced in last month 0.2 0.3 0.8 -0.9 0.0 0.5
Supplements: Calcium 0.7 0.8 2.1 -0.5 1.4 -0.3
Basal cell carcinoma (self-reported) 1.0 1.1 2.2 1.5 -0.8 -0.8
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.3 0.2 0.6 0.1
Deep venous thrombosis (DVT) (self-reported) 2.6 3.4 6.0 1.9 -2.4 -0.8
Heart disease (siblings) 0.6 0.7 1.5 0.7 0.1 -1.2
Alcohol drinker status: Previous 1.1 1.2 1.9 1.3 -1.4 -0.3
Pack years of smoking 0.5 0.7 1.6 0.5 -1.3 -0.5
Impedance of whole body 0.7 3.5 4.7 -2.2 1.5 1.9
Leg fat mass (left) 3.0 11.6 16.8 3.5 -2.3 -4.1
Arm predicted mass (left) 2.2 11.4 17.0 3.2 -2.6 -4.1