Best TWAS P=9.74e-138 · Best GWAS P=8.89e-122 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SIDT2 | 0.07 | 0.06 | lasso | 5 | 0.05 | 8.8e-07 | 8.2 | -9.1 | 6.6e-20 | -0.30 | 0.99 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | ZNF259 | 0.08 | 0.03 | enet | 6 | 0.03 | 1.2e-04 | 18.7 | -25.0 | 9.7e-138 | -0.27 | 0.02 | 0.98 | TRUE |
| 3 | GTEx | Artery Aorta | PCSK7 | 0.30 | 0.22 | lasso | 6 | 0.25 | 6.0e-14 | 5.7 | -6.1 | 1.0e-09 | -0.19 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Coronary | PCSK7 | 0.23 | 0.07 | lasso | 5 | 0.07 | 2.2e-03 | 5.7 | -7.1 | 1.6e-12 | -0.21 | 0.34 | 0.04 | FALSE |
| 5 | GTEx | Artery Tibial | PCSK7 | 0.25 | 0.15 | lasso | 7 | 0.19 | 1.1e-14 | 7.7 | -6.9 | 5.0e-12 | -0.21 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Brain Cerebellum | PAFAH1B2 | 0.30 | 0.03 | enet | 20 | 0.06 | 6.0e-03 | 7.8 | -5.3 | 1.0e-07 | -0.24 | 0.11 | 0.05 | FALSE |
| 7 | GTEx | Cells EBV-transformed lymphocytes | TAGLN | 0.42 | 0.06 | enet | 22 | 0.18 | 1.4e-06 | 5.8 | -5.9 | 3.1e-09 | -0.17 | 0.70 | 0.03 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | PCSK7 | 0.14 | 0.11 | lasso | 5 | 0.11 | 6.7e-09 | 6.4 | 7.8 | 5.0e-15 | 0.22 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Cells Transformed fibroblasts | PAFAH1B2 | 0.11 | 0.00 | lasso | 3 | 0.00 | 1.3e-01 | 16.8 | -17.9 | 1.4e-71 | -0.54 | 0.06 | 0.22 | TRUE |
| 10 | GTEx | Colon Sigmoid | PCSK7 | 0.28 | 0.09 | lasso | 8 | 0.15 | 6.5e-06 | 18.5 | -15.1 | 1.7e-51 | -0.48 | 0.82 | 0.01 | FALSE |
| 11 | GTEx | Esophagus Muscularis | PCSK7 | 0.18 | 0.09 | lasso | 3 | 0.10 | 9.2e-07 | 7.7 | -7.7 | 2.0e-14 | -0.26 | 0.97 | 0.00 | FALSE |
| 12 | GTEx | Lung | SIDT2 | 0.08 | 0.08 | lasso | 4 | 0.07 | 6.8e-06 | 5.6 | -6.5 | 9.3e-11 | -0.20 | 0.98 | 0.00 | FALSE |
| 13 | GTEx | Lung | PCSK7 | 0.09 | 0.01 | enet | 28 | 0.02 | 6.4e-03 | 12.1 | 5.7 | 1.3e-08 | 0.12 | 0.54 | 0.02 | FALSE |
| 14 | GTEx | Pancreas | SIDT2 | 0.17 | 0.12 | lasso | 3 | 0.08 | 1.9e-04 | 7.8 | -7.1 | 9.1e-13 | -0.27 | 0.38 | 0.04 | FALSE |
| 15 | GTEx | Pancreas | TAGLN | 0.12 | 0.06 | lasso | 5 | 0.01 | 1.4e-01 | 5.6 | -9.2 | 2.9e-20 | -0.27 | 0.21 | 0.04 | FALSE |
| 16 | GTEx | Skin Not Sun Exposed Suprapubic | PCSK7 | 0.20 | 0.05 | enet | 31 | 0.07 | 7.0e-05 | 8.4 | 11.4 | 6.9e-30 | 0.30 | 0.26 | 0.08 | TRUE |
| 17 | GTEx | Skin Sun Exposed Lower leg | SIDT2 | 0.11 | 0.00 | enet | 13 | 0.01 | 9.0e-02 | 5.9 | -5.6 | 2.7e-08 | -0.12 | 0.14 | 0.07 | FALSE |
| 18 | GTEx | Testis | SIDT2 | 0.23 | 0.01 | enet | 33 | 0.05 | 1.9e-03 | 5.2 | 6.2 | 4.7e-10 | 0.14 | 0.31 | 0.08 | FALSE |
| 19 | GTEx | Testis | TAGLN | 0.15 | 0.05 | lasso | 5 | 0.04 | 8.0e-03 | 12.7 | -14.3 | 2.9e-46 | -0.46 | 0.36 | 0.03 | FALSE |
| 20 | GTEx | Thyroid | SIDT2 | 0.06 | 0.02 | lasso | 2 | 0.02 | 5.8e-03 | 8.4 | -8.7 | 4.3e-18 | -0.23 | 0.07 | 0.74 | TRUE |
| 21 | GTEx | Whole Blood | SIDT2 | 0.18 | 0.06 | lasso | 7 | 0.04 | 2.3e-04 | 7.7 | -7.8 | 4.2e-15 | -0.27 | 0.95 | 0.00 | FALSE |
| 22 | GTEx | Whole Blood | TAGLN | 0.24 | 0.19 | lasso | 5 | 0.19 | 6.1e-17 | 5.8 | -7.3 | 3.7e-13 | -0.22 | 1.00 | 0.00 | FALSE |
| 23 | METSIM | Adipose | SIDT2 | 0.09 | 0.07 | lasso | 7 | 0.07 | 2.3e-10 | 7.8 | -8.8 | 1.5e-18 | -0.25 | 1.00 | 0.00 | FALSE |
| 24 | METSIM | Adipose | TAGLN | 0.04 | 0.04 | lasso | 4 | 0.04 | 2.8e-06 | 7.8 | -7.4 | 1.2e-13 | -0.24 | 0.97 | 0.00 | FALSE |
| 25 | NTR | Blood | PAFAH1B2 | 0.04 | 0.04 | enet | 6 | 0.04 | 1.0e-12 | 6.3 | 5.5 | 3.8e-08 | 0.11 | 1.00 | 0.00 | FALSE |
| 26 | NTR | Blood | SIDT2 | 0.12 | 0.15 | lasso | 4 | 0.15 | 2.3e-46 | 7.8 | -7.4 | 1.2e-13 | -0.24 | 1.00 | 0.00 | FALSE |
| 27 | NTR | Blood | TAGLN | 0.03 | 0.04 | lasso | 8 | 0.03 | 3.7e-09 | 5.8 | -6.9 | 6.9e-12 | -0.22 | 1.00 | 0.00 | FALSE |
| 28 | ROSMAP | Brain Pre-frontal Cortex | SIDT2 | 0.10 | 0.16 | lasso | 2 | 0.15 | 1.3e-18 | 5.7 | -6.0 | 1.4e-09 | -0.19 | 1.00 | 0.00 | FALSE |
| 29 | ROSMAP | Brain Pre-frontal Cortex | PAFAH1B2 | 0.09 | 0.04 | lasso | 4 | 0.05 | 1.3e-06 | 8.4 | 9.0 | 3.1e-19 | 0.21 | 1.00 | 0.00 | FALSE |
| 30 | YFS | Blood | PAFAH1B2 | 0.01 | 0.02 | lasso | 5 | 0.01 | 3.0e-05 | 6.4 | -6.9 | 6.5e-12 | -0.21 | 0.92 | 0.00 | TRUE |
| 31 | YFS | Blood | PCSK7 | 0.11 | 0.13 | lasso | 12 | 0.15 | 7.6e-48 | 5.7 | 7.6 | 3.4e-14 | 0.21 | 1.00 | 0.00 | FALSE |
| 32 | YFS | Blood | SIDT2 | 0.40 | 0.40 | enet | 46 | 0.46 | 1.3e-168 | 7.8 | -8.5 | 2.2e-17 | -0.27 | 1.00 | 0.00 | FALSE |
| 33 | YFS | Blood | TAGLN | 0.37 | 0.47 | enet | 47 | 0.54 | 1.3e-213 | 5.7 | -8.2 | 2.1e-16 | -0.27 | 1.00 | 0.00 | FALSE |
| 34 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PCSK7 | 0.04 | 0.02 | blup | 51 | 0.02 | 4.4e-03 | 5.9 | 10.8 | 5.9e-27 | 0.30 | 0.07 | 0.77 | FALSE |
| 35 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PCSK7 | 0.03 | 0.03 | blup | 51 | 0.03 | 1.9e-06 | 5.9 | 5.5 | 3.1e-08 | 0.16 | 0.96 | 0.00 | FALSE |
| 36 | The Cancer Genome Atlas | Colon Adenocarcinoma | SIDT2 | 0.11 | 0.00 | blup | 46 | 0.05 | 8.2e-04 | 8.0 | -11.2 | 5.2e-29 | -0.35 | 0.01 | 0.49 | FALSE |
| 37 | The Cancer Genome Atlas | Glioblastoma Multiforme | TAGLN | 0.15 | 0.00 | blup | 48 | -0.01 | 6.6e-01 | 5.7 | 7.6 | 3.4e-14 | 0.18 | 0.01 | 0.46 | FALSE |
| 38 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PCSK7 | 0.04 | 0.03 | lasso | 3 | 0.03 | 5.6e-04 | 8.1 | 9.2 | 4.8e-20 | 0.30 | 0.30 | 0.63 | FALSE |
| 39 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PCSK7 | 0.08 | 0.10 | lasso | 2 | 0.09 | 1.9e-10 | 6.2 | 6.3 | 3.5e-10 | 0.18 | 1.00 | 0.00 | FALSE |
| 40 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PCSK7 | 0.07 | 0.08 | lasso | 5 | 0.09 | 5.5e-06 | 5.2 | 6.1 | 8.2e-10 | 0.21 | 0.76 | 0.13 | FALSE |
| 41 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SIDT2 | 0.08 | 0.01 | blup | 46 | 0.05 | 2.4e-06 | 12.8 | -11.5 | 9.3e-31 | -0.36 | 0.11 | 0.34 | FALSE |
| 42 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | BUD13 | 0.24 | 0.03 | blup | 76 | 0.08 | 1.8e-04 | -1.6 | -14.3 | 2.0e-46 | -0.28 | 0.03 | 0.05 | TRUE |
| 43 | The Cancer Genome Atlas | Lung Adenocarcinoma | SIDT2 | 0.02 | 0.01 | blup | 46 | 0.01 | 4.6e-02 | 10.0 | -10.2 | 2.9e-24 | -0.34 | 0.05 | 0.21 | FALSE |
| 44 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SIK3 | 0.04 | 0.04 | enet | 8 | 0.03 | 5.2e-04 | 11.6 | 11.6 | 3.4e-31 | 0.20 | 0.74 | 0.01 | FALSE |
| 45 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZNF259 | 0.04 | 0.03 | lasso | 3 | 0.02 | 8.4e-04 | 21.6 | -22.4 | 3.9e-111 | -0.07 | 0.19 | 0.08 | TRUE |
| 46 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | BUD13 | 0.08 | 0.00 | blup | 76 | 0.01 | 9.2e-02 | -2.3 | -20.0 | 5.2e-89 | -0.31 | 0.02 | 0.04 | FALSE |
| 47 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SIDT2 | 0.16 | 0.08 | enet | 10 | 0.04 | 1.2e-02 | -2.8 | -6.3 | 2.1e-10 | -0.19 | 0.03 | 0.12 | FALSE |
| 48 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PCSK7 | 0.03 | 0.01 | blup | 51 | 0.02 | 3.8e-03 | 12.8 | 9.5 | 1.5e-21 | 0.33 | 0.02 | 0.78 | FALSE |
| 49 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SIDT2 | 0.03 | 0.03 | blup | 46 | 0.03 | 2.4e-04 | 8.0 | -8.5 | 2.0e-17 | -0.29 | 0.12 | 0.71 | TRUE |
| 50 | The Cancer Genome Atlas | Thyroid Carcinoma | PCSK7 | 0.12 | 0.20 | enet | 18 | 0.19 | 3.0e-18 | 5.9 | 5.8 | 8.3e-09 | 0.18 | 1.00 | 0.00 | FALSE |
| 51 | The Cancer Genome Atlas | Thyroid Carcinoma | SIDT2 | 0.03 | 0.01 | blup | 46 | 0.02 | 4.9e-03 | 8.0 | -5.2 | 1.7e-07 | -0.22 | 0.01 | 0.48 | FALSE |