Best TWAS P=2.28e-11 · Best GWAS P=4.69e-18 conditioned to 0.496
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | NEURL2 | 0.20 | 0.06 | lasso | 3 | 0.06 | 4.2e-04 | 8.7 | -6.4 | 1.4e-10 | -0.87 | 0.00 | 0.98 | FALSE |
| 2 | GTEx | Artery Coronary | PLTP | 0.34 | 0.07 | lasso | 5 | 0.10 | 2.6e-04 | 7.2 | -6.7 | 2.3e-11 | -0.68 | 0.02 | 0.87 | TRUE |
| 3 | GTEx | Brain Cerebellar Hemisphere | SNX21 | 0.41 | 0.09 | enet | 16 | 0.05 | 2.1e-02 | 4.9 | 5.8 | 5.3e-09 | 0.47 | 0.06 | 0.39 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | RP3-337O18.9 | 0.18 | 0.00 | lasso | 5 | 0.00 | 4.0e-01 | 5.5 | -5.2 | 2.4e-07 | -0.46 | 0.10 | 0.31 | FALSE |
| 5 | GTEx | Nerve Tibial | PLTP | 0.11 | 0.01 | enet | 27 | 0.01 | 4.6e-02 | 3.8 | -6.6 | 3.3e-11 | -0.53 | 0.04 | 0.78 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | CTSA | 0.15 | 0.06 | enet | 20 | 0.12 | 7.7e-15 | 7.2 | -6.6 | 5.5e-11 | -0.72 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Glioblastoma Multiforme | MMP9 | 0.25 | 0.16 | enet | 6 | 0.16 | 1.2e-05 | 4.9 | -5.3 | 9.6e-08 | -0.42 | 0.01 | 0.72 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PLTP | 0.17 | 0.03 | blup | 52 | 0.06 | 7.0e-07 | 8.5 | -6.0 | 2.5e-09 | -0.48 | 0.01 | 0.97 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | ZSWIM1 | 0.04 | 0.01 | blup | 41 | 0.01 | 9.5e-03 | 8.5 | 6.3 | 3.1e-10 | 0.62 | 0.01 | 0.63 | TRUE |
| 10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PLTP | 0.34 | 0.00 | lasso | 3 | 0.05 | 2.8e-03 | 8.7 | -6.1 | 1.1e-09 | -0.69 | 0.00 | 0.57 | FALSE |
| 11 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PLTP | 0.15 | 0.03 | blup | 51 | 0.05 | 1.1e-03 | 8.7 | -6.3 | 2.8e-10 | -0.68 | 0.00 | 0.85 | TRUE |