TWAS hub - ACTN4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1680	0.0430	2.5e-07	0.111	NA	0.113	NA	0.130	1.1e-08	NA	8.9e-09	NA	6.0e-10
2	GTEx	Muscle Skeletal	0.0762	0.0261	2.2e-04	0.064	NA	0.035	NA	0.053	6.5e-07	NA	2.1e-04	NA	5.9e-06
3	YFS	Blood	0.0476	0.0132	5.2e-09	0.018	0.035	0.043	0.036	0.042	1.2e-06	1.7e-11	6.3e-14	6.4e-12	1.3e-13
4	TCGA	Colon Adenocarcinoma	0.0490	0.0310	9.1e-03	-0.002	-0.005	-0.002	NA	0.006	4.2e-01	8.0e-01	4.5e-01	NA	1.3e-01
5	TCGA	Prostate Adenocarcinoma	0.0565	0.0311	1.3e-03	0.016	0.021	0.018	NA	0.013	7.0e-03	2.8e-03	4.7e-03	NA	1.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Pulse rate, automated reading	12.0	38.8	67.3	-8.2	-8.1	-4.6	-4.1	-4.8
Pulse rate	10.6	17.9	34.5	-5.9	-5.8	-3.1	-2.4	-2.5
Blood Platelet Count	7.0	81.5	161.3	-11.0	-8.0	-7.8	-1.1	-12.7
Loneliness, isolation	4.6	6.4	8.8	3.0	2.8	2.7	1.6	2.3
Illnesses of father: High blood pressure	4.2	5.2	7.9	2.8	2.1	2.5	1.3	2.3
Depression (Nagel 2018)	3.6	5.4	8.6	2.9	2.7	1.8	1.8	2.2
Allergy or Eczema	3.6	9.5	18.0	-3.3	-4.1	-1.3	-4.2	-0.3
High blood pressure (mother)	3.6	5.1	8.8	2.7	3.0	-0.1	2.3	2.0
Prostate Cancer	3.5	5.0	8.6	2.4	2.1	2.9	-0.3	2.4
Depression (self-reported)	3.5	4.2	7.6	2.8	2.2	1.4	0.1	2.6
Medication: Atorvastatin	3.5	4.4	9.1	-2.3	-3.0	-2.0	-1.1	-1.5
Multivitamins +/- minerals	3.3	4.3	8.3	2.9	2.1	1.9	-0.1	2.2
Birth weight	3.3	7.1	15.8	-3.4	-2.8	-0.5	-0.8	-4.0
Medication: Lansoprazole	3.2	3.7	5.9	2.4	1.8	2.3	1.0	1.8
Financial difficulties in last 2 years	3.1	4.2	10.6	2.3	1.0	1.9	0.4	3.3
Alzheimer’s Disease (including proxy)	3.0	4.3	7.5	-2.5	-2.7	-0.4	-2.6	-0.7
Frequency of tenseness / restlessness in last 2 weeks	3.0	4.7	10.3	3.2	2.5	2.1	0.9	1.2
Eye problems/disorders: Glaucoma	3.0	3.6	6.9	-2.2	-1.5	-2.6	-0.7	-1.8
Irritability	3.0	5.1	8.7	2.9	2.1	1.4	1.5	2.9
Frequency of depressed mood in last 2 weeks	2.8	3.9	5.7	2.3	2.4	1.5	1.7	1.8
Type 2 Diabetes (T2D) (2012)	2.7	3.1	8.1	1.3	0.9	2.8	1.0	2.0
Medication: Bendroflumethiazide	2.7	4.2	6.2	2.5	2.5	1.7	1.7	1.6
Medication: Seretide 50 evohaler	2.6	3.0	5.3	-2.3	-2.3	-1.5	-1.0	-1.2
Mean time to correctly identify matches	2.6	4.9	9.1	2.5	2.4	1.1	3.0	1.4
Alcohol intake frequency.	2.6	6.0	8.2	2.9	2.5	2.7	2.4	1.6
Diabetes (father)	2.5	3.1	5.9	2.0	0.8	2.2	0.7	2.4
Had major operations	2.5	2.9	4.3	-2.1	-1.4	-2.0	-0.5	-2.0
Age at first live birth	2.4	4.3	7.6	2.7	2.8	0.9	1.7	1.8
Medication: Metformin	2.3	3.3	9.8	1.6	1.0	1.3	1.2	3.1
Lung cancer (father)	2.3	2.7	5.4	1.2	1.6	1.5	2.3	1.4
Bipolar Disorder or Schizophrenia	2.2	5.3	13.0	2.2	2.4	3.6	0.7	1.6
Coronary Artery Disease (CAD)	2.2	2.6	5.5	-1.6	-2.4	-1.4	-1.6	0.7
Chronic bronchitis/emphysema (father)	2.2	2.6	4.3	1.8	2.1	1.1	1.9	0.8
Migraine (self-reported)	2.2	2.7	6.6	1.6	1.4	2.6	1.4	0.5
Alcohol drinker status: Previous	2.2	2.5	4.3	1.5	1.3	2.1	1.1	1.8
Reaction Time	2.1	4.0	6.1	2.4	2.3	1.2	2.5	1.2
Number of children fathered	2.1	2.3	3.1	-1.6	-1.7	-1.0	-1.4	-1.7
Mouth/teeth dental problems: Loose teeth	2.1	2.5	4.9	1.9	1.3	1.1	1.1	2.2
Alcohol drinker status: Never	2.1	2.6	6.0	1.4	1.5	1.3	2.4	1.0
Hayfever, allergic rhinitis or eczema	2.0	4.3	7.5	-2.3	-2.7	-1.0	-2.7	0.2
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	7.1	2.7	2.4	0.9	1.3	0.9
Medication: Cholesterol lowering	2.0	3.1	5.5	-2.2	-2.3	-1.0	0.6	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.1	5.4	2.3	1.6	1.5	0.5	2.3
Age at last live birth	2.0	2.9	4.8	2.2	2.2	0.9	1.1	1.6
Diastolic blood pressure, automated reading	2.0	6.3	14.1	-3.0	-3.8	-1.2	-2.7	0.1
Vitamin and mineral supplements	1.9	2.5	4.9	-2.2	-2.0	-0.9	-0.2	-1.8
Alzheimer’s Disease (in father)	1.8	2.0	4.0	-1.7	-2.0	0.5	-1.5	-0.8
Lung FEV1/FVC ratio	1.8	9.4	17.3	-4.0	-2.6	-2.3	-1.2	-4.2
Hand grip strength (left)	1.8	4.8	10.1	-2.4	-3.2	-0.7	-2.8	-0.0
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	3.8	-2.0	-1.1	-1.6	-1.5	-1.1
Handedness (chirality/laterality): Left-handed	1.8	2.1	5.5	1.2	1.7	-0.7	2.4	0.7
Wears glasses or contact lenses	1.8	2.1	3.8	-1.9	-1.9	-1.1	-0.8	-1.0
Schizophrenia (2018)	1.7	3.5	9.7	1.4	1.5	3.1	0.5	1.8
HDL Cholesterol	1.7	2.8	7.0	1.8	2.6	0.2	2.0	0.1
Number of treatments/medications taken	1.7	3.0	6.5	2.5	1.8	1.8	0.8	1.3
Number of incorrect matches in round	1.7	2.8	9.2	0.9	1.7	-1.1	3.0	-0.3
Hair/balding pattern: Pattern 3	1.7	2.6	7.7	-1.7	-0.6	-1.2	0.7	-2.8
Age started oral contraceptive pill	1.7	2.1	3.6	1.6	1.9	0.9	1.4	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	4.1	2.0	1.7	1.5	0.9	0.8
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	3.7	-1.4	-1.9	0.2	-1.8	1.3
Medication: Paracetamol	1.6	2.7	5.1	2.3	2.2	1.6	-0.5	0.7
Family relationship satisfaction	1.6	2.0	5.3	1.1	1.6	0.8	2.3	0.2
Myopia	1.6	2.4	5.1	1.3	2.1	0.5	2.2	0.6
Respiratory disease	1.5	3.4	8.7	-3.0	-2.2	-0.9	-0.1	-1.7
Hand grip strength (right)	1.5	4.1	10.4	-2.2	-3.2	-0.3	-2.3	0.1
Diabetes diagnosed by doctor	1.5	2.5	4.7	1.7	1.2	1.6	0.9	2.2
Mouth/teeth dental problems: Mouth ulcers	1.5	2.5	8.7	1.1	0.3	0.7	-1.3	2.9
Medication: Gliclazide	1.5	1.7	3.1	1.3	1.1	1.5	0.6	1.8
Bipolar Disorder (2018)	1.4	2.2	3.7	1.9	1.9	1.9	0.6	0.3
Falls in the last year	1.4	1.9	4.4	2.1	1.4	0.3	0.7	1.6
Commuting to job workplace: Public transport	1.4	1.7	3.2	1.3	1.6	1.0	1.8	0.4
Medication: Blood pressure	1.4	2.7	5.2	1.6	1.1	2.3	-0.6	2.0
Pain type(s) experienced in last month: Hip pain	1.4	1.8	4.3	0.6	-0.9	1.5	-2.1	1.3
Fractured/broken bones in last 5 years	1.4	1.8	5.4	0.6	1.5	0.8	2.3	0.8
Alzheimer’s Disease (in mother)	1.3	1.5	2.5	-1.4	-1.5	-0.8	-1.6	0.6
Fasting Glucose	1.3	1.5	2.9	1.6	1.7	0.6	1.2	0.7
Schizophrenia (2014)	1.3	2.8	8.9	1.0	1.3	3.0	0.8	1.3
Blood White Count	1.3	9.5	18.0	4.2	4.1	1.3	2.9	1.6
Allergy	1.3	3.1	5.5	2.3	2.3	0.4	2.1	0.2
Birth weight of first child	1.3	2.3	3.2	1.4	1.8	1.2	1.6	1.6
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.4	-1.9	-2.1	-0.3	-0.3	0.6
Glaucoma (self-reported)	1.3	1.6	5.4	-1.0	-0.4	-2.3	0.7	-1.0
Qualifications: College or University degree	1.3	4.1	7.5	2.7	2.1	1.1	0.4	2.7
Medication for cholesterol	1.3	2.0	3.4	-1.6	-1.1	-1.8	-0.2	-1.6
Commuting to job workplace: Cycle	1.3	1.5	2.9	1.6	1.7	0.6	0.2	1.4
Verbal and Numeric Reasoning (VNR)	1.2	2.8	5.6	1.7	1.7	1.5	2.4	0.9
Rheumatoid Arthritis	1.2	1.7	3.7	-1.1	-1.0	0.4	-1.6	-1.9
Supplements: Zinc	1.2	1.3	2.4	1.3	0.8	0.6	-1.1	1.5
Townsend deprivation index at recruitment	1.2	1.7	2.8	1.4	1.7	0.9	1.5	0.6
Average weekly fortified wine intake	1.2	1.4	3.9	1.2	2.0	-0.1	1.2	-0.2
Diabetes (self-reported)	1.2	1.8	3.3	1.1	0.9	1.6	1.1	1.8
Asthma	1.2	2.3	4.8	-2.2	-1.3	-0.9	-0.3	-2.0
Forced vital capacity (FVC), Best measure	1.2	4.5	7.2	2.7	2.3	2.0	-0.1	2.3
Number of full sisters	1.2	1.5	5.2	1.0	0.3	2.3	0.2	1.1
Asthma (self-reported)	1.2	2.3	5.2	-2.3	-1.4	-1.0	-0.1	-1.9
High cholesterol (Self-reported)	1.2	2.2	4.5	-1.9	-2.1	-0.0	0.1	-1.7
Triglycerides	1.1	1.9	3.6	-1.8	-1.9	-0.9	-1.0	-0.8
Pulse wave reflection index	1.1	1.4	2.7	1.4	1.6	-0.3	-0.2	1.5
Emphysema/chronic bronchitis	1.1	1.3	3.7	0.8	0.5	0.2	1.9	1.3
Overall health rating	1.1	2.3	3.0	1.4	1.4	1.7	1.5	1.4
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.8	-0.7	-0.9	1.3	-1.7	-0.7
Breast cancer (self-reported)	1.1	1.3	2.8	-0.7	-0.8	-1.6	-1.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	5.2	2.3	2.3	0.5	-0.6	0.8
Supplements: Calcium	1.1	1.2	2.3	1.4	0.7	1.0	-0.6	1.5
Hypothyroidism (self reported)	1.0	2.2	3.8	-0.2	-1.5	1.6	-1.6	2.0
Type 2 Diabetes (T2D) (2018)	1.0	1.8	2.7	1.3	1.3	1.3	1.1	1.6
Chronotype (morning person)	1.0	2.2	5.8	-1.3	-1.6	-0.7	-2.4	-0.7
Tense / ‘highly strung’	1.0	1.6	5.4	1.1	1.0	-0.6	0.2	2.3
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.6	0.4	1.2	1.6	1.4	-0.5
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.3	-1.3	-1.5	-0.7	0.6	1.0
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.8	-0.9	-0.4	-1.7	1.4	-0.3
Ever had bowel cancer screening	1.0	1.2	2.0	1.4	0.9	0.9	0.8	1.4
Irritable Bowel Disease (IBD)	0.9	2.2	8.7	0.8	-0.2	0.6	-1.0	2.9
Waist Hip Ratio (WHR)	0.9	3.9	11.8	1.6	0.7	2.0	0.1	3.4
Nervous feelings	0.9	1.6	2.5	-1.2	-1.6	-1.0	-1.4	1.1
Forced vital capacity (FVC)	0.9	3.4	6.2	2.5	2.1	1.3	-0.4	2.2
Impedance of arm (left)	0.9	4.0	11.6	1.2	2.5	-0.6	3.4	0.7
Blood clot in the leg (DVT)	0.9	1.2	2.9	1.3	1.0	1.7	-0.1	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	4.1	0.9	0.7	0.4	-0.1	2.0
Pulse wave peak to peak time	0.9	1.1	2.1	1.4	1.3	0.7	1.0	0.2
Medication for pain relief, constipation, heartburn	0.9	1.6	3.5	-1.9	-1.6	-1.1	-0.0	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	1.7	-0.9	-1.0	-1.3	-1.1	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.6	0.6	-0.4	1.3	-0.4	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.9	0.9	1.4	0.7	1.2	-0.3
Medication: Paracetamol	0.9	1.5	2.6	1.6	1.5	1.1	-0.9	0.6
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.8	1.2	0.6	1.4	0.6	1.2
Depressed Affect (Nagel 2018)	0.8	1.6	3.6	0.8	1.1	0.7	1.9	1.4
Crohns Disease (2012)	0.8	1.3	5.0	0.2	-0.6	0.6	-0.9	2.2
Neuroticism (2016)	0.8	1.1	2.6	-0.5	-0.6	-1.6	-1.5	-0.2
Qualifications: CSEs or equivalent	0.8	1.0	2.3	-1.1	-1.2	-0.4	-0.2	-1.5
Hair/balding pattern: Pattern 2	0.8	1.0	2.0	1.3	1.1	0.2	0.3	1.4
Qualifications: None of the above	0.8	1.7	4.2	-1.2	-1.1	-1.0	-2.0	-1.0
Medication: Ramipril	0.8	1.0	2.6	-0.5	-0.8	1.2	-0.5	1.6
Time employed in main current job	0.8	0.9	2.5	-1.2	-0.7	0.1	0.5	-1.6
Alcohol intake versus 10 years previously	0.8	1.2	2.2	1.2	1.5	0.6	1.4	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.2	1.5	1.2	0.2	0.5	0.9
Length of working week for main job	0.8	0.9	3.1	0.0	-0.6	1.8	-1.0	0.3
Peak expiratory flow (PEF)	0.8	1.9	4.4	-0.4	-1.0	1.5	-2.1	1.3
Headache pain in last month	0.8	1.3	3.4	1.8	1.2	-0.8	0.8	0.7
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	2.9	-0.7	-1.5	1.1	-1.1	1.7
Medication: Amlodipine	0.8	1.1	4.4	0.6	0.7	2.1	0.3	0.1
High blood pressure (siblings)	0.8	1.1	3.1	0.7	0.8	0.7	1.8	0.9
Exposure to tobacco smoke outside home	0.8	1.1	2.8	0.1	1.1	0.4	1.1	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.9	-0.3	-1.1	-0.6	-1.4	0.9
Angina (self-reported)	0.8	1.0	1.9	-1.4	-1.0	-1.1	0.1	-1.1
Medication: Ibuprofen	0.8	1.0	2.5	1.6	1.5	0.1	0.1	0.3
Mood swings	0.8	1.4	2.9	1.5	1.2	0.0	0.7	1.7
Illnesses of father: None of the above (group 1)	0.8	1.0	3.0	-0.5	-0.0	-1.7	-0.5	-1.2
Schizophrenia vs Biploar Disorder	0.7	0.9	2.4	-1.5	-1.4	0.3	-0.1	0.3
Crohns Disease (2017)	0.7	1.5	6.7	0.4	-0.3	-0.1	-0.6	2.6
Angina	0.7	1.0	1.6	-1.3	-0.8	-1.0	0.2	-1.2
Medication for hormone replacement therapy	0.7	0.8	2.7	0.0	0.6	-0.5	1.7	-0.6
Medication: Levothyroxine sodium	0.7	1.2	3.3	-0.4	-0.8	1.4	-0.2	1.8
Had other major operations	0.7	0.9	4.1	0.4	0.5	2.0	0.1	-0.1
Fluid intelligence score	0.7	1.5	3.9	1.4	1.3	0.2	2.0	0.5
Neuroticism score	0.7	1.5	6.8	0.4	-0.5	-0.0	-0.6	2.6
Impedance of arm (right)	0.7	3.4	8.9	1.3	2.4	-0.4	3.0	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	2.9	1.6	1.3	1.7	-1.1	1.6
Pulse wave Arterial Stiffness index	0.7	0.8	1.5	-1.2	-1.2	-0.3	-0.8	0.3
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.7	1.0	1.1	1.3	0.7	0.2
Heart disease (mother)	0.7	0.9	3.1	0.6	0.4	1.8	0.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.8	-1.0	-1.6	0.2	-1.9	0.2
Qualifications: nursing, teaching	0.7	1.1	2.2	0.0	-1.0	0.6	-1.4	1.5
Unable to work because of sickness or disability	0.7	0.9	1.5	1.2	1.2	0.7	0.8	0.8
Cholesterol lowering medication	0.7	1.1	4.0	0.7	-0.1	2.0	-0.7	0.7
Basal cell carcinoma (self-reported)	0.7	0.8	1.4	1.2	1.2	1.0	0.6	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	2.8	1.0	0.8	1.7	-0.1	0.7
Intelligence (Savage-Jansen 2018)	0.6	1.9	6.3	1.1	1.4	0.3	2.5	0.2
Ulcerative Colitis	0.6	0.9	2.1	0.8	-0.2	1.4	-0.6	1.1
Lung FVC	0.6	2.8	7.9	2.2	2.8	-0.7	0.3	-0.9
Average weekly spirits intake	0.6	0.7	3.1	-0.3	0.6	0.1	0.3	-1.7
Ever had hysterectomy (womb removed)	0.6	0.7	1.1	-0.7	-0.9	0.8	-0.7	1.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.6	0.1	0.2	1.3	0.8	1.2
Maternal smoking around birth	0.6	0.9	2.1	-1.4	-1.2	0.7	0.5	-0.6
Relative age voice broke	0.6	0.9	1.9	1.4	0.9	-0.6	1.0	0.3
Stomach or abdominal pain in last month	0.6	0.7	2.5	1.6	0.5	0.6	-0.3	0.5
Supplements: Glucosamine	0.6	0.7	1.1	-0.7	-1.0	-0.5	-1.0	-1.0
Heart attack	0.6	0.8	2.1	-0.7	-1.4	0.1	-1.0	0.7
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	2.9	1.7	1.5	1.3	-0.8	1.5
Hair/balding pattern: Pattern 4	0.6	1.5	2.4	-1.6	-1.3	-1.3	-0.8	-1.0
Comparative body size at age 10	0.6	1.6	3.7	-1.0	-0.6	0.0	-1.8	-1.9
Number of full brothers	0.6	0.7	1.4	1.1	1.2	0.3	0.9	0.2
Shortness of breath walking on level ground	0.6	0.8	2.0	-0.6	-0.7	1.4	-1.0	-0.1
Chest pain or discomfort	0.6	0.9	1.3	0.7	0.9	1.1	0.8	-1.1
Illnesses of siblings: Diabetes	0.6	0.8	2.0	0.6	-0.3	0.4	-1.1	1.4
Long-standing illness, disability or infirmity	0.6	0.9	2.2	0.9	0.4	1.5	0.3	1.0
Friendships satisfaction	0.6	0.8	2.0	0.5	0.8	1.0	1.4	-0.3
Back pain experienced in last month	0.6	0.9	3.1	0.9	0.6	1.8	0.1	0.1
Osteoporosis (self-reported)	0.6	0.8	1.4	1.0	1.1	-0.2	1.2	-0.5
Average weekly champagne plus white wine intake	0.6	0.8	1.7	-0.8	-1.0	-0.9	-0.1	-1.3
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.6	0.9	1.0	-0.3	-0.6	-1.3
Medication: Lisinopril	0.6	0.7	1.4	1.2	0.3	0.9	-1.0	0.6
Ever had prostate specific antigen (PSA) test	0.6	0.6	1.6	-0.6	-0.3	-1.0	-0.4	-1.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.0	-0.7	-1.4	-0.0	-1.0	0.7
Ulcerative Colitis (UC)	0.5	1.0	2.4	0.7	-0.1	1.3	-0.3	1.6
Body Mass Index (BMI) (2010)	0.5	0.7	1.4	-1.2	-1.0	-0.2	-0.8	-0.8
Primary Biliary Cirrhosis	0.5	0.7	1.6	-0.9	-1.3	0.9	-0.6	0.2
Blood Red Count	0.5	4.7	17.8	1.3	-0.4	1.5	-1.3	4.2
Heel T-Score	0.5	4.0	9.2	-0.4	-1.4	1.7	-3.0	2.4
Height	0.5	9.4	30.9	2.8	1.1	2.5	0.8	5.6
Sensitivity / hurt feelings	0.5	0.9	2.0	-0.8	-1.3	-0.3	-1.4	-0.3
Hearing difficulty/problems: Yes	0.5	0.8	1.6	-1.0	-1.0	0.5	-1.3	0.2
Fed-up feelings	0.5	0.9	3.0	0.5	0.5	0.5	1.0	1.7
Taking other prescription medications	0.5	0.8	3.3	0.7	0.1	0.6	-0.1	1.8
Age when periods started (menarche)	0.5	1.3	2.8	-1.7	-1.5	0.1	-0.8	-0.8
Serious illness, injury or assault to yourself	0.5	0.6	1.3	0.3	-0.4	0.9	0.7	1.1
Hearing difficulty/problems with background noise	0.5	0.7	1.5	-0.3	-0.8	-1.1	-1.2	0.3
Mouth/teeth dental problems	0.5	0.8	1.7	0.7	1.3	-0.6	-0.2	-1.2
Medication: Simvastatin	0.5	0.7	1.7	0.1	-0.2	1.3	1.3	-0.6
Illnesses of siblings	0.5	0.8	3.3	0.1	0.0	-0.7	-1.8	0.3
Father’s age at death	0.5	0.7	1.6	-0.5	-0.8	-1.3	-0.9	-0.5
Worry too long after embarrassment	0.5	0.8	1.5	-0.1	-1.0	-0.4	-1.1	1.2
Eye problems/disorders: None of the above	0.5	0.5	1.3	0.5	0.6	-1.1	-0.2	-0.9
Medication: Allopurinol	0.5	0.7	2.0	0.3	0.4	-1.4	1.1	-0.4
Suffer from ‘nerves’	0.5	0.8	1.4	1.0	0.6	0.2	-1.2	1.0
Leg pain on walking	0.5	0.6	1.9	1.4	0.8	0.3	0.5	0.5
Hypertension (Self-reported)	0.5	1.4	3.6	1.1	0.3	1.5	-0.0	1.9
Guilty feelings	0.5	0.7	1.5	-0.7	-1.2	-0.3	-0.6	1.0
Ever smoked	0.5	0.8	1.6	-0.5	-0.7	-0.6	-1.3	1.2
Arm fat-free mass (left)	0.5	2.4	4.5	-0.8	-2.0	1.5	-2.1	0.7
Average weekly beer plus cider intake	0.5	0.8	1.8	0.1	0.8	1.0	1.3	-0.6
Arm predicted mass (left)	0.5	2.6	5.2	-0.8	-2.0	1.6	-2.3	0.6
Neuroticism (Nagel 2018)	0.4	1.0	2.4	0.8	0.7	0.6	1.1	1.6
Major Depression (MDD)	0.4	0.5	1.5	-0.7	-0.7	0.1	-1.2	-0.1
HbA1C	0.4	0.4	1.4	-0.4	-0.3	0.3	-0.5	-1.2
Blood Eosinophil Count	0.4	3.1	6.5	-1.9	-2.3	2.5	-0.4	-0.4
Relative age of first facial hair	0.4	0.8	1.7	-0.6	-0.9	-1.3	-1.1	-0.0
Systolic blood pressure, automated reading	0.4	1.2	2.5	1.4	1.6	0.5	1.1	0.2
Medication: Co-codamol	0.4	0.4	0.8	0.6	0.4	0.9	0.0	0.9
Current tobacco smoking	0.4	0.6	0.9	0.7	0.9	-0.7	0.4	-0.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.3	-0.7	-1.1	-0.4	-0.7	0.3
Sitting height	0.4	3.1	11.2	-1.2	-1.5	0.6	0.2	3.3
Body mass index (BMI)	0.4	1.5	2.9	-1.1	-1.2	1.1	-0.9	-1.7
Alcohol usually taken with meals	0.4	0.7	1.4	0.9	1.2	0.4	1.1	-0.1
Trunk fat-free mass	0.4	2.3	3.4	-0.4	-1.8	1.7	-1.6	1.6
Worrier / anxious feelings	0.4	0.7	1.9	-0.2	-1.0	-0.2	-0.6	1.4
Happiness	0.4	0.4	1.8	-0.4	0.4	-1.4	0.1	-0.2
Noisy workplace	0.4	0.5	0.9	0.4	0.9	-0.5	0.9	-0.5
Prospective memory result	0.4	0.4	1.9	-0.0	-0.2	-0.4	0.1	-1.4
Trunk predicted mass	0.4	2.3	3.3	-0.4	-1.8	1.7	-1.6	1.6
Standing height	0.4	3.6	15.1	0.5	-0.7	1.4	-0.2	3.9
Loud music exposure frequency	0.4	0.5	1.1	-0.3	-0.0	-1.0	0.3	-1.1
Leg fat percentage (right)	0.4	1.5	3.7	-0.9	-1.0	1.4	-0.3	-1.9
Arm fat-free mass (right)	0.4	2.0	3.7	-0.8	-1.9	1.3	-1.8	0.7
Arm predicted mass (right)	0.4	2.2	4.7	-1.1	-2.2	1.2	-1.9	0.5
Knee pain experienced in last month	0.4	0.6	1.8	0.1	0.2	-0.7	0.9	-1.4
Illnesses of father: Heart disease	0.4	0.6	1.3	-0.1	-0.5	1.2	-0.9	0.6
Commuting to job workplace: Walk	0.4	0.5	0.7	-0.8	-0.8	-0.7	-0.7	-0.4
Eye problems/disorders: Cataract	0.4	0.5	1.2	-0.5	-0.6	0.8	1.1	-0.3
Mineral and other dietary supplements	0.4	0.6	0.9	-0.9	-0.8	0.3	0.9	0.7
Leg fat percentage (left)	0.4	1.6	3.8	-0.9	-0.9	1.5	-0.6	-1.9
Impedance of whole body	0.4	1.8	4.1	0.8	1.6	-0.7	2.0	1.1
Worry (Nagel 2018)	0.3	0.5	1.4	-0.1	-0.6	-0.3	-0.9	1.2
BMI	0.3	1.9	3.2	-1.0	-1.2	1.8	-1.4	-1.2
Cardiovascular Disease	0.3	0.9	1.8	-0.5	-1.0	1.1	-1.3	0.5
Neuroticism	0.3	0.7	2.4	0.3	-0.6	-0.0	-0.8	1.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.9	0.2	-0.1	1.0	0.3	0.8
Pack years adult smoking proportion	0.3	0.4	1.2	0.2	-0.1	-0.8	-1.1	-0.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.2	0.3	-0.0	1.1	-0.4	0.8
Medication: Atenolol	0.3	0.4	1.0	0.5	0.4	-0.2	1.0	0.6
Arm fat percentage (right)	0.3	1.3	4.5	-0.9	-0.6	0.7	0.2	-2.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.4	-0.2	-0.0	-0.1	1.2	0.4
Illnesses of mother	0.3	0.4	1.1	-0.1	-0.2	-0.1	-1.0	-1.0
Arm fat mass (right)	0.3	1.3	1.9	-1.1	-1.4	1.2	-0.9	-1.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.6	1.5	0.7	-0.2	0.9	1.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.7	0.7	1.3	0.1	-0.7	0.4
Body fat percentage	0.3	1.0	3.5	-0.8	-0.2	0.8	0.7	-1.9
Health satisfaction	0.3	0.4	1.0	-0.3	-0.9	0.1	-1.0	-0.2
Neck or shoulder pain in last month	0.3	0.4	0.8	0.3	-0.4	0.9	-0.9	0.4
Leg fat mass (right)	0.3	1.2	2.9	-0.8	-1.2	1.7	-0.3	-1.0
Medication: Aspirin	0.3	0.4	0.9	0.4	0.7	0.9	-0.3	-0.4
Supplements: Vitamin C	0.3	0.3	1.1	0.6	1.0	0.1	0.3	0.3
Smoking status: Previous	0.3	0.4	1.1	-1.1	-0.8	-0.1	-0.2	0.2
Whole body fat-free mass	0.3	1.7	3.2	-0.5	-1.6	1.8	-1.2	1.0
Arm fat percentage (left)	0.3	1.1	4.2	-0.7	-0.3	0.7	0.5	-2.1
Smoking status: Current	0.3	0.5	1.1	0.6	0.8	-0.5	0.4	-1.1
Whole body water mass	0.3	1.8	2.8	-0.6	-1.7	1.7	-1.4	1.0
Miserableness	0.3	0.5	1.1	-0.9	-0.5	-1.1	0.5	-0.2
Mother’s age at death	0.3	0.4	0.8	-0.9	-0.9	-0.5	-0.4	-0.3
Financial situation satisfaction	0.3	0.3	1.3	0.3	0.4	-0.4	-0.1	1.1
Basal metabolic rate	0.3	1.5	3.1	-0.5	-1.5	1.8	-1.1	0.7
Risk taking	0.3	0.4	1.3	0.4	0.4	1.1	0.3	0.5
Pain experienced in last month	0.3	0.4	1.1	-0.4	0.3	0.9	0.1	1.1
Heart disease (siblings)	0.3	0.3	0.8	-0.1	-0.6	0.9	0.6	-0.2
Leg fat mass (left)	0.3	1.2	3.2	-0.7	-1.0	1.8	-0.5	-1.0
Breast Cancer	0.2	0.5	1.3	0.7	1.2	0.3	0.6	0.2
Age at First Birth	0.2	0.3	1.0	0.2	0.3	0.1	1.0	-0.6
Bipolar Disorder (2011)	0.2	0.2	1.0	0.0	0.0	0.0	1.0	0.0
LDL Cholesterol	0.2	0.3	0.8	-0.9	0.0	-0.7	0.4	-0.6
Tanning	0.2	2.0	3.2	1.8	1.6	0.9	1.6	1.0
Diabetes (mother)	0.2	0.2	0.5	-0.5	-0.3	-0.1	0.6	-0.7
Severe depression (siblings)	0.2	0.2	0.6	0.6	0.8	-0.3	0.0	0.3
Leg fat-free mass (left)	0.2	0.9	3.4	-0.3	-0.9	1.8	-0.4	0.5
Trunk fat percentage	0.2	1.0	2.9	-1.0	-0.3	0.6	0.7	-1.7
High blood pressure	0.2	0.7	1.8	0.8	0.2	1.0	0.3	1.3
Leg predicted mass (left)	0.2	0.9	3.3	-0.2	-0.8	1.8	-0.2	0.4
Trunk fat mass	0.2	0.8	1.3	-0.8	-0.7	1.1	0.3	-1.1
Waist circumference	0.2	0.7	2.1	-0.6	-0.9	1.4	-0.5	-0.2
Past tobacco smoking	0.2	0.3	0.9	0.5	0.3	-0.5	-0.4	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.9	-0.4	-0.5	1.4	-0.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.3	-0.0	0.4	0.6	0.6
Pain all over the body in last month	0.2	0.2	0.4	-0.4	-0.3	0.6	-0.6	0.0
Weight	0.2	1.1	2.7	-0.7	-1.2	1.6	-0.7	-0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.3	0.8	0.7	-0.1	1.2	-0.3
Breastfed as a baby	0.2	0.2	0.8	-0.2	-0.4	-0.9	0.5	-0.1
Gout (self-reported)	0.2	0.3	1.4	-0.1	0.0	-0.3	1.2	-0.4
Medication: Omeprazole	0.2	0.3	0.6	0.6	0.2	0.8	0.6	0.4
Whole body fat mass	0.2	0.9	1.8	-0.9	-0.9	1.4	0.2	-1.0
Leg fat-free mass (right)	0.2	0.8	2.7	-0.2	-0.8	1.7	-0.7	0.6
Osteoarthritis (self-reported)	0.2	0.2	0.3	-0.4	-0.5	0.5	-0.3	-0.6
Medication: Aspirin	0.2	0.3	0.6	0.4	0.8	0.5	-0.3	-0.7
Leg predicted mass (right)	0.2	0.9	2.9	-0.2	-0.8	1.7	-0.7	0.5
Arm fat mass (left)	0.2	0.8	1.2	-0.7	-1.0	1.1	-0.6	-1.1
Number of self-reported non-cancer illnesses	0.2	0.4	0.9	-0.1	-0.5	0.9	0.1	0.9
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.2	-0.6	-0.8	0.3	0.2
Hearing aid user	0.2	0.3	0.8	-0.1	0.1	-0.9	0.2	-0.7
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	0.1	0.6	-0.5	0.7	0.1
Ever depressed for a whole week	0.2	0.2	0.8	-0.1	0.3	-0.4	0.9	0.1
Ovarian Cancer	0.1	0.1	0.2	0.5	0.3	-0.0	-0.2	-0.3
Mean Putamen Volume	0.1	0.2	0.3	-0.4	-0.4	0.3	0.3	-0.5
Lupus	0.1	0.2	0.4	0.4	0.4	0.6	0.3	-0.5
Systolic Blood Pressure	0.1	0.7	1.3	0.9	1.2	0.7	0.2	0.9
Smoking Status	0.1	0.3	0.8	0.4	0.5	0.1	0.9	0.3
Hair Pigment	0.1	1.9	5.7	-0.5	-1.6	-0.4	-2.4	0.9
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.2	0.0	-0.4	-0.4	0.1
Impedance of leg (right)	0.1	0.5	1.5	-0.0	0.1	-0.7	0.5	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.3	-0.4	-0.5	0.4	-0.1	-0.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.3	-0.1	0.3	-0.4	-0.3
Impedance of leg (left)	0.1	0.5	2.1	0.1	0.1	-0.4	-0.1	1.5
Had menopause	0.1	0.1	0.3	-0.5	-0.3	0.0	0.3	-0.2
Hip circumference	0.1	0.6	2.0	-0.6	-0.4	1.4	0.0	-0.4
Number of live births	0.1	0.1	0.2	0.4	0.4	0.0	0.2	0.1
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.6	0.2	0.2	-0.4	0.2
Wheeze or whistling in the chest in last year	0.1	0.1	0.3	-0.4	-0.1	0.5	-0.2	-0.2
Medication: Blood pressure	0.1	0.2	0.5	0.6	0.0	0.3	0.7	0.3
Comparative height size at age 10	0.1	0.6	1.4	-0.2	-1.0	0.8	-0.1	1.2
Average weekly red wine intake	0.1	0.2	0.5	0.4	0.7	0.1	0.1	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.2	-0.3	0.0	-0.3	0.4
Number of operations (self-reported)	0.1	0.2	0.6	0.2	0.2	0.3	0.8	0.0
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.3	0.1	0.5	-0.6	0.0	-0.4
Pack years of smoking	0.1	0.2	0.7	0.3	-0.1	-0.5	-0.8	0.0
Mouth/teeth dental problems: Dentures	0.0	0.1	0.2	0.1	-0.3	0.0	0.4	0.1

Hub : Genes

ACTN4

Models

Trait associations