TWAS hub - LGALS7B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0670	0.0267	2.4e-06	0.031	0.037	0.035	NA	0.030	3.9e-07	3.4e-08	1.0e-07	NA	7.4e-07
2	TCGA	Cervical Squamous Cell Carcinoma	0.2240	0.0700	6.8e-08	0.149	0.130	0.155	NA	0.150	8.5e-08	6.3e-07	4.7e-08	NA	7.7e-08
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.1909	0.0511	0.0e+00	0.213	0.171	0.193	NA	0.210	1.6e-23	8.5e-19	2.9e-21	NA	3.5e-23
4	TCGA	Lung Squamous Cell Carcinoma	0.1426	0.0412	1.7e-16	0.179	0.174	0.188	NA	0.188	6.3e-20	2.3e-19	6.1e-21	NA	6.7e-21
5	TCGA	Pancreatic Adenocarcinoma	0.0850	0.0420	4.7e-03	0.033	0.051	0.061	NA	0.053	1.6e-02	3.4e-03	1.5e-03	NA	3.0e-03
6	TCGA	Prostate Adenocarcinoma	0.0687	0.0317	3.6e-05	0.071	0.049	0.061	NA	0.062	6.5e-08	6.8e-06	5.2e-07	NA	4.7e-07
7	TCGA	Testicular Germ Cell Tumors	0.2130	0.0860	1.9e-03	0.138	0.016	0.073	NA	0.047	1.4e-05	8.7e-02	1.4e-03	NA	8.9e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Pulse rate	7.3	12.4	24.3	-2.7	-4.9	-3.2	-3.5	-3.2	-3.7	-2.9
Mineral and other dietary supplements	5.6	7.5	9.6	-1.7	-2.5	-3.0	-3.0	-3.1	-2.8	-2.8
Pulse rate, automated reading	5.5	17.8	35.5	-1.6	-6.0	-3.6	-4.2	-5.0	-4.5	-3.2
Supplements: Fish oil (including cod liver oil)	5.1	6.7	8.4	1.9	2.3	2.9	2.5	2.7	2.8	2.8
Vitamin and mineral supplements	4.9	6.6	10.5	-0.9	-2.5	-2.7	-2.8	-3.2	-2.7	-2.6
Medication: Seretide 50 evohaler	4.6	5.3	7.5	-0.9	-2.4	-2.4	-2.7	-2.7	-2.3	-2.2
Pain type(s) experienced in last month: Hip pain	4.6	5.8	7.6	-2.8	-2.3	-2.4	-2.5	-2.2	-2.2	-2.4
Birth weight of first child	4.4	8.0	9.3	2.0	3.0	2.9	3.0	2.9	3.0	2.9
Number of children fathered	4.1	4.6	6.0	-1.3	-2.3	-2.3	-2.0	-2.0	-2.4	-2.4
Hayfever/allergic rhinitis (self-reported)	4.0	5.3	7.3	-2.7	-2.5	-2.3	-2.3	-1.6	-2.3	-2.3
Frequency of depressed mood in last 2 weeks	3.9	5.5	7.2	1.3	2.7	2.3	2.4	2.5	2.6	2.4
Pain all over the body in last month	3.3	3.5	4.6	2.0	1.5	2.0	2.1	1.2	1.9	2.1
Myopia	3.1	4.5	5.0	2.0	2.1	2.1	1.9	2.2	2.2	2.2
Chronic bronchitis/emphysema (father)	3.0	3.5	5.1	2.3	1.9	1.6	2.0	1.1	2.0	2.0
Qualifications: O levels/GCSEs or equivalent	3.0	4.7	5.9	-2.1	-2.4	-2.4	-2.1	-1.9	-1.9	-2.3
Medication for cholesterol, blood pressure or diabetes	3.0	5.0	7.6	1.1	2.8	2.6	2.3	2.1	2.2	2.3
Prostate Cancer	2.9	4.1	6.0	1.2	2.1	2.1	2.5	1.8	2.2	2.1
Allergy or Eczema	2.9	7.6	11.4	-2.9	-3.4	-2.6	-2.8	-1.7	-3.0	-2.7
Hand grip strength (right)	2.9	7.8	10.6	-2.8	-3.3	-2.7	-2.9	-2.1	-3.0	-2.7
Medication: Ramipril	2.9	3.7	5.3	-1.3	-1.5	-2.3	-1.9	-1.9	-2.1	-2.2
Eye problems/disorders: Cataract	2.9	3.4	5.0	-1.3	-2.2	-1.9	-2.1	-2.1	-1.6	-1.6
Prospective memory result	2.8	3.4	4.4	2.1	1.6	2.0	1.8	1.9	1.7	1.9
Ever highly irritable/argumentative for 2 days	2.7	3.2	3.6	1.5	1.8	1.9	1.8	1.8	1.8	1.9
Supplements: Vitamin C	2.7	3.2	3.5	1.8	1.7	1.8	1.7	1.6	1.8	1.9
Wears glasses or contact lenses	2.6	2.9	3.9	-1.4	-2.0	-1.7	-2.0	-1.3	-1.9	-1.7
Loneliness, isolation	2.5	3.4	5.2	0.2	2.3	1.7	1.8	2.2	2.2	1.8
Depression (Nagel 2018)	2.4	3.7	5.9	0.4	2.4	1.8	2.0	2.0	2.2	1.9
Medication: Cholesterol lowering	2.4	3.8	6.8	0.2	-2.6	-2.0	-2.0	-2.5	-1.8	-1.6
Pulse wave reflection index	2.4	3.0	5.1	1.8	2.3	1.6	2.1	1.1	1.5	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	3.9	-1.8	-1.6	-2.0	-1.5	-1.2	-1.6	-1.9
Hayfever, allergic rhinitis or eczema	2.3	5.0	6.5	-2.5	-2.5	-2.1	-2.4	-1.3	-2.4	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	3.0	1.2	1.4	1.7	1.4	1.4	1.7	1.7
Worry (Nagel 2018)	2.0	4.2	5.9	-2.4	-2.0	-2.0	-2.2	-1.7	-1.9	-2.0
Fractured/broken bones in last 5 years	2.0	2.6	3.5	1.5	1.7	1.7	1.6	0.8	1.8	1.9
Diastolic blood pressure, automated reading	2.0	6.2	12.3	-1.6	-3.5	-2.2	-2.5	-2.6	-2.5	-2.0
Crohns Disease (2012)	1.9	3.0	3.3	-1.6	-1.8	-1.8	-1.8	-1.6	-1.8	-1.8
HDL Cholesterol	1.9	3.1	5.2	0.3	2.1	1.8	1.9	2.3	1.7	1.5
Blood Eosinophil Count	1.9	14.6	21.7	-3.5	-3.6	-4.0	-4.7	-2.8	-3.9	-4.1
Multivitamins +/- minerals	1.9	2.4	5.5	-0.6	1.7	1.5	1.4	2.3	1.6	1.3
Nervous feelings	1.9	3.6	4.7	-1.7	-1.9	-2.0	-2.0	-1.4	-2.2	-2.0
Financial difficulties in last 2 years	1.9	2.5	3.4	0.5	1.8	1.7	1.7	1.7	1.7	1.6
Heart attack	1.9	2.4	4.0	-0.5	-1.5	-1.8	-1.4	-2.0	-1.6	-1.5
Medication: Blood pressure	1.9	3.3	5.0	-1.2	-1.9	-2.2	-1.9	-1.5	-1.8	-2.0
Worrier / anxious feelings	1.8	3.5	4.8	-2.2	-2.1	-1.8	-2.1	-1.4	-1.6	-1.7
Lung cancer (father)	1.8	2.1	2.8	0.9	1.4	1.3	1.7	1.7	1.7	1.4
Mean time to correctly identify matches	1.8	3.4	9.5	-0.1	2.1	1.6	1.6	3.1	1.7	1.5
Leg pain on walking	1.8	2.2	3.3	0.5	0.9	1.8	1.6	1.7	1.6	1.8
Ever taken oral contraceptive pill	1.8	2.0	3.0	-1.7	-1.4	-1.6	-1.5	-0.8	-1.2	-1.4
Medication: Atorvastatin	1.7	2.1	4.6	0.6	-1.8	-1.3	-1.1	-2.1	-1.4	-1.1
Heart attack/myocardial infarction (self-reported)	1.7	2.2	3.8	-0.4	-1.6	-1.7	-1.3	-1.9	-1.5	-1.4
Reaction Time	1.6	3.0	8.6	-0.4	2.2	1.3	1.3	2.9	1.4	1.2
Hand grip strength (left)	1.6	4.2	6.9	-1.8	-2.6	-1.9	-2.0	-1.7	-2.2	-1.9
Gout (self-reported)	1.6	2.2	3.3	-1.3	-1.7	-1.6	-1.8	-1.4	-1.3	-1.4
Chronic bronchitis/emphysema (mother)	1.6	1.9	5.3	-0.8	-2.3	-1.4	-1.4	-1.3	-1.0	-0.9
Exposure to tobacco smoke outside home	1.6	2.1	3.0	1.7	1.4	1.5	1.5	0.7	1.5	1.6
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	2.8	-0.7	-1.6	-1.4	-1.4	-1.4	-1.7	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	4.8	-2.2	-1.5	-2.0	-1.5	-0.9	-2.1	-2.2
Medication: Metformin	1.5	2.1	8.1	-2.8	-0.9	-1.5	-0.7	-0.1	-1.0	-1.4
Diabetes (mother)	1.5	2.0	4.3	2.1	1.2	1.3	1.5	0.7	1.3	1.4
Peak expiratory flow (PEF)	1.5	3.4	5.7	-1.8	-1.2	-2.1	-1.6	-1.1	-2.3	-2.4
Smoking status: Previous	1.5	2.2	3.1	1.2	0.8	1.6	1.8	1.5	1.4	1.7
Commuting to job workplace: Cycle	1.5	1.8	2.8	1.2	1.7	1.3	1.5	1.0	1.4	1.3
Diabetes (father)	1.4	1.8	3.7	-1.9	-0.9	-1.5	-1.6	-0.3	-0.9	-1.4
Noisy workplace	1.4	1.7	2.2	1.2	1.4	1.4	1.0	1.2	1.5	1.4
Qualifications: nursing, teaching	1.4	2.2	4.2	-2.0	-1.2	-1.6	-1.1	-0.9	-1.6	-1.6
LDL Cholesterol	1.3	2.1	3.0	1.7	1.5	1.4	1.7	1.0	1.2	1.4
Triglycerides	1.3	2.1	3.3	-0.1	-1.5	-1.5	-1.5	-1.8	-1.6	-1.4
Waist Hip Ratio (WHR)	1.3	5.8	7.7	-2.6	-2.0	-2.6	-2.8	-2.1	-2.2	-2.5
Falls in the last year	1.3	1.8	2.4	0.1	1.5	1.3	1.4	1.5	1.5	1.3
Birth weight	1.3	2.8	3.8	0.4	-1.9	-1.6	-2.0	-1.8	-1.9	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	5.8	1.2	2.4	1.4	1.7	1.9	1.4	1.1
Commuting to job workplace: Public transport	1.3	1.5	2.7	0.6	1.3	1.2	1.0	1.6	1.3	1.2
High cholesterol (Self-reported)	1.3	2.2	5.4	0.9	-1.2	-1.5	-1.5	-2.3	-1.5	-1.2
Age started oral contraceptive pill	1.3	1.6	2.7	0.3	1.3	1.4	1.1	1.3	1.6	1.4
Unable to work because of sickness or disability	1.3	1.7	2.8	1.5	1.7	1.3	1.4	0.7	1.1	1.2
Alzheimer’s Disease (in father)	1.2	1.3	2.3	-0.1	-1.0	-1.1	-1.1	-1.5	-1.4	-1.2
Body Mass Index (BMI) (2010)	1.2	1.7	2.6	-0.6	-0.9	-1.4	-1.4	-1.4	-1.5	-1.6
Townsend deprivation index at recruitment	1.2	1.7	2.5	1.0	1.4	1.2	1.4	1.6	1.3	1.1
Age when periods started (menarche)	1.2	2.8	4.4	-1.1	-1.8	-1.7	-1.5	-2.1	-1.7	-1.5
Medication: Simvastatin	1.2	1.8	3.3	-0.9	-0.9	-1.6	-1.8	-0.8	-1.4	-1.6
Happiness	1.2	1.4	2.0	-1.0	-0.5	-1.3	-1.2	-1.3	-1.3	-1.4
Pulse wave Arterial Stiffness index	1.2	1.4	2.3	-0.8	-1.2	-1.2	-1.1	-1.5	-1.3	-1.2
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.9	-1.5	-1.7	-1.2	-1.3	-0.6	-1.3	-0.9
Number of self-reported non-cancer illnesses	1.2	2.1	3.5	-1.9	-1.5	-1.4	-1.7	-0.5	-1.3	-1.4
Depressed Affect (Nagel 2018)	1.1	2.3	3.7	0.6	1.5	1.4	1.5	1.6	1.9	1.7
Primary Biliary Cirrhosis	1.1	1.5	4.1	-0.2	-2.0	-0.9	-1.4	-1.4	-1.1	-0.8
High blood pressure (mother)	1.1	1.6	4.3	0.3	2.1	1.0	1.2	0.8	1.5	1.0
Number of incorrect matches in round	1.1	1.8	3.9	1.0	1.1	1.2	0.8	2.0	1.5	1.4
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	4.6	0.2	-0.7	-1.3	-0.6	-2.1	-1.0	-1.0
Alcohol intake versus 10 years previously	1.1	1.6	3.6	0.8	1.4	1.2	0.6	1.9	1.3	1.2
Schizophrenia vs Biploar Disorder	1.0	1.4	2.9	-0.7	-1.1	-1.3	-0.6	-1.7	-1.3	-1.1
Respiratory disease	1.0	2.3	3.4	-0.7	-1.8	-1.5	-1.8	-1.6	-1.6	-1.3
Maternal smoking around birth	1.0	1.5	3.0	0.2	-1.2	-1.3	-1.0	-1.7	-1.2	-1.2
Medication: Atenolol	1.0	1.3	2.1	1.1	0.8	1.1	1.5	1.1	1.1	1.1
Past tobacco smoking	1.0	1.8	2.9	-1.2	-1.0	-1.4	-1.7	-1.2	-1.3	-1.5
Osteoporosis (self-reported)	1.0	1.2	2.8	0.4	0.9	1.2	0.7	1.7	1.2	1.1
Alzheimer’s Disease (in mother)	0.9	1.0	2.0	-1.0	-0.5	-1.2	-0.6	-0.6	-1.4	-1.4
Alzheimer’s Disease (including proxy)	0.9	1.3	3.5	-0.8	-0.7	-1.1	-0.6	-0.7	-1.9	-1.5
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.9	0.6	1.0	1.3	1.6	2.0	1.7	1.5
Blood Platelet Count	0.9	10.4	24.0	4.9	-2.5	-1.9	-3.0	-4.1	-3.0	-2.0
Alcohol usually taken with meals	0.9	1.4	2.5	0.5	0.9	1.2	1.2	1.6	1.4	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.6	-0.6	1.6	1.1	0.9	1.4	1.4	1.0
Qualifications: College or University degree	0.9	2.7	4.0	0.3	1.6	1.6	2.0	2.0	1.8	1.6
Average weekly beer plus cider intake	0.9	1.3	1.9	1.2	1.1	1.2	1.0	0.7	1.4	1.4
Irritable Bowel Disease (IBD)	0.8	1.8	2.6	-1.3	-1.0	-1.6	-1.1	-1.1	-1.6	-1.6
Fasting Glucose	0.8	1.0	1.7	1.1	1.2	1.3	1.2	0.7	0.3	0.5
Smoking Status	0.8	1.9	3.2	1.2	1.8	1.2	1.4	1.5	1.2	1.2
Pulse wave peak to peak time	0.8	1.0	1.9	0.5	1.0	0.9	0.9	1.4	1.1	0.9
Eye problems/disorders: None of the above	0.8	0.9	1.9	0.8	1.2	1.0	0.6	1.4	0.8	0.6
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.5	-0.0	-1.6	-0.7	-1.0	-1.1	-0.7	-0.7
Intelligence (Savage-Jansen 2018)	0.7	2.2	3.1	0.9	1.1	1.4	1.8	1.5	1.8	1.6
Heel T-Score	0.7	5.4	7.0	-2.6	-2.4	-2.5	-1.9	-1.6	-2.5	-2.5
Impedance of leg (right)	0.7	3.3	5.5	-1.1	-2.1	-1.9	-1.8	-2.3	-1.5	-1.6
Blood clot in the leg (DVT)	0.7	0.9	1.5	0.2	0.9	1.2	1.0	0.6	1.2	1.1
Medication: Paracetamol	0.7	1.1	2.3	0.1	1.5	1.1	1.1	1.2	1.1	0.8
Had major operations	0.7	0.8	1.7	0.6	-0.8	-0.7	-0.7	-1.3	-1.0	-0.8
Medication: Aspirin	0.7	0.9	2.1	1.5	0.6	0.9	0.9	0.4	1.0	1.0
Medication: Gliclazide	0.7	0.7	4.1	-2.0	-0.2	-0.4	0.1	0.8	-0.2	-0.5
Financial situation satisfaction	0.7	0.9	2.3	0.8	1.5	0.8	1.2	0.6	0.7	0.7
Alcohol drinker status: Never	0.7	0.9	1.6	-1.3	-1.0	-0.9	-1.2	-0.8	-0.4	-0.7
Alcohol drinker status: Previous	0.7	0.8	1.9	0.8	1.4	0.7	0.8	0.4	1.0	0.9
Ulcerative Colitis (UC)	0.6	1.1	1.8	-1.3	-0.6	-1.2	-0.8	-0.2	-1.2	-1.3
Ulcerative Colitis	0.6	0.8	1.1	-1.0	-0.9	-1.0	-0.8	-0.3	-1.0	-1.0
Blood Red Count	0.6	6.1	10.4	-3.2	-2.3	-2.7	-2.6	-1.2	-2.2	-2.5
Hypothyroidism (self reported)	0.6	1.4	3.9	-2.0	-1.6	-0.9	-1.0	-0.4	-1.0	-0.9
Chronotype (morning person)	0.6	1.5	2.5	-1.0	-1.4	-1.1	-1.2	-0.4	-1.6	-1.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.2	-1.1	-0.7	-0.8	-0.7	0.1	-0.7	-0.9
Hair/balding pattern: Pattern 2	0.6	0.8	1.4	-0.0	1.2	0.8	1.0	0.9	0.9	0.7
Fluid intelligence score	0.6	1.2	2.6	0.4	0.7	1.0	1.2	1.6	1.3	1.1
Father’s age at death	0.6	0.9	1.6	-0.4	-1.0	-0.9	-1.1	-1.3	-0.8	-0.8
Exposure to tobacco smoke at home	0.6	0.7	1.2	0.1	0.3	1.1	1.0	0.9	0.9	0.9
Loud music exposure frequency	0.6	0.7	0.9	0.6	0.7	0.9	0.7	1.0	0.9	1.0
Leg fat percentage (right)	0.6	2.2	3.9	0.0	-1.3	-1.5	-1.6	-2.0	-1.6	-1.5
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.3	-1.4	0.3	0.4	0.2	1.5	0.4	0.3
Age at last live birth	0.6	0.8	2.4	-1.0	0.8	0.5	0.7	1.6	0.8	0.4
Friendships satisfaction	0.6	0.7	1.1	-1.1	-0.2	-0.9	-0.8	-0.8	-0.7	-1.0
Breast cancer (self-reported)	0.6	0.7	1.4	-0.4	-0.3	-0.9	-0.6	-1.1	-1.2	-1.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.1	1.1	0.8	0.7	0.8	0.7	0.7	0.8
Supplements: Calcium	0.6	0.7	1.5	-0.7	0.5	0.9	0.4	1.2	1.0	0.9
Pack years of smoking	0.6	0.9	2.2	-0.4	-0.8	-1.0	-0.8	-1.5	-0.9	-0.9
Crohns Disease (2017)	0.5	1.2	2.2	-0.6	-0.8	-1.3	-0.9	-1.5	-1.2	-1.1
HbA1C	0.5	0.6	1.2	-1.1	-0.8	-1.1	-0.9	-0.6	0.1	-0.4
Cardiovascular Disease	0.5	1.5	1.9	-1.1	-1.1	-1.2	-1.4	-1.3	-1.4	-1.2
Lung FVC	0.5	2.6	5.3	1.4	2.3	1.3	1.6	1.8	1.5	1.1
Medication: Co-codamol	0.5	0.6	1.0	1.0	0.9	0.7	0.6	0.3	0.8	0.8
Stomach or abdominal pain in last month	0.5	0.6	2.0	-1.4	-0.5	-0.6	-1.0	-0.2	-0.4	-0.7
Impedance of leg (left)	0.5	2.5	4.9	-0.9	-1.9	-1.6	-1.5	-2.2	-1.2	-1.3
Hearing difficulty/problems with background noise	0.5	0.8	1.2	-1.1	-1.0	-1.0	-0.6	-0.3	-1.1	-1.0
Allergy	0.5	1.2	2.2	1.4	1.5	0.6	1.2	0.7	1.1	0.8
Neuroticism score	0.5	1.0	2.9	-1.7	-1.2	-0.9	-1.0	-0.7	-0.5	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.4	-0.4	1.1	0.6	0.8	1.2	1.0	0.6
Length of working week for main job	0.5	0.5	2.2	-1.5	-0.5	-0.5	-0.4	-0.0	-0.6	-0.7
Breastfed as a baby	0.5	0.6	0.8	-0.8	-0.4	-0.9	-0.6	-0.9	-0.8	-0.9
Medication for pain relief, constipation, heartburn	0.5	0.8	1.1	-0.7	-1.0	-0.9	-1.0	-0.7	-1.1	-0.9
Alcohol intake frequency.	0.5	1.2	2.7	-0.5	1.3	0.9	0.2	1.6	1.4	1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.7	-0.7	-0.5	-0.7	-0.5	-1.3	-0.7	-0.6
Back pain experienced in last month	0.5	0.7	0.9	0.0	1.0	1.0	0.8	0.8	0.9	0.9
Medication: Aspirin	0.5	0.7	1.7	1.3	0.7	0.8	0.7	0.4	0.8	0.8
Miserableness	0.5	0.8	1.3	1.1	0.6	0.8	0.9	0.6	0.9	1.1
Mother’s age at death	0.5	0.6	1.4	-0.1	-1.2	-0.6	-0.9	-0.8	-0.7	-0.6
Illnesses of father: High blood pressure	0.5	0.6	2.4	-1.5	-0.2	-0.4	-1.1	-0.6	0.0	-0.4
Risk taking	0.5	0.7	1.2	0.5	0.9	1.0	0.7	0.4	1.1	1.1
Neuroticism	0.4	0.9	1.4	-1.2	-1.2	-0.8	-0.7	-1.2	-0.5	-0.6
Average weekly spirits intake	0.4	0.5	0.9	-0.2	0.1	-0.7	-0.7	-0.8	-0.8	-0.9
Ever had hysterectomy (womb removed)	0.4	0.4	0.7	-0.8	-0.6	-0.6	-0.8	-0.5	-0.6	-0.5
Angina	0.4	0.5	2.4	1.6	0.3	-0.3	0.0	-0.6	-0.4	-0.3
Pack years adult smoking proportion	0.4	0.6	1.6	-0.3	-0.6	-0.8	-0.5	-1.3	-0.8	-0.8
Depression (self-reported)	0.4	0.5	2.2	-0.0	1.5	0.5	0.8	0.0	0.6	0.4
Worry too long after embarrassment	0.4	0.7	1.9	-1.4	-1.2	-0.5	-0.7	-0.3	-0.6	-0.5
Health satisfaction	0.4	0.5	1.0	-1.0	-0.5	-0.6	-0.7	-0.6	-0.8	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	0.3	-0.7	-0.7	-0.4	-1.2	-0.6	-0.5
Leg fat mass (right)	0.4	1.6	2.2	-0.4	-1.1	-1.4	-1.4	-1.5	-1.4	-1.4
Number of full sisters	0.4	0.5	2.8	-1.7	-0.3	-0.2	-0.5	0.3	-0.2	-0.4
Hypertension (Self-reported)	0.4	1.0	2.4	-1.5	-0.9	-1.0	-1.2	0.1	-0.8	-0.9
Illnesses of father: Heart disease	0.4	0.5	0.7	-0.8	-0.6	-0.8	-0.6	-0.8	-0.6	-0.7
Illnesses of siblings: Diabetes	0.4	0.5	1.7	-1.3	-0.4	-0.6	-0.5	0.6	-0.5	-0.6
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	0.9	1.0	0.6	0.5	0.1	0.8	0.7
Mood swings	0.4	0.8	1.4	0.3	0.9	0.8	0.8	0.9	1.2	0.9
Long-standing illness, disability or infirmity	0.4	0.5	1.0	0.5	0.8	0.7	1.0	0.5	0.8	0.8
Illnesses of father: None of the above (group 1)	0.4	0.4	0.7	0.5	0.6	0.8	0.8	0.8	0.5	0.5
Leg fat percentage (left)	0.4	1.4	2.9	0.3	-1.1	-1.2	-1.2	-1.7	-1.2	-1.1
Number of operations (self-reported)	0.4	0.6	0.9	-0.5	-0.1	-0.9	-0.8	-0.8	-0.7	-1.0
Irritability	0.4	0.7	1.3	-1.0	0.4	0.5	0.7	0.8	1.2	0.8
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.7	0.7	1.3	1.0	1.1	1.0	0.9	0.8
Cholesterol lowering medication	0.4	0.5	1.1	-0.4	0.2	-0.9	-0.8	-0.6	-0.9	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.8	-0.0	0.8	0.9	0.8	0.5	0.8	0.8
Ovarian Cancer	0.3	0.3	0.6	-0.7	-0.8	-0.5	-0.6	-0.3	-0.4	-0.6
Age at First Birth	0.3	0.5	1.3	-0.4	-0.8	-0.5	-1.1	-0.1	-0.7	-0.7
Lupus	0.3	0.4	1.7	-1.3	-0.3	-0.4	-0.4	0.3	-0.4	-0.5
Medication for hormone replacement therapy	0.3	0.3	1.3	1.1	0.6	0.1	0.2	-0.6	0.3	0.3
Trunk fat percentage	0.3	1.1	2.4	0.6	-0.7	-1.2	-1.1	-1.5	-1.0	-1.0
Average weekly fortified wine intake	0.3	0.3	0.8	-0.9	0.3	-0.4	-0.7	-0.3	-0.4	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	-0.1	0.8	0.6	0.6	0.3	1.0	0.8
High blood pressure	0.3	0.9	1.3	-1.1	-1.0	-1.0	-1.1	-0.4	-0.8	-0.8
Sitting height	0.3	2.2	3.1	-1.8	-1.2	-1.7	-1.0	-1.0	-1.8	-1.6
Trunk fat mass	0.3	1.5	2.4	0.1	-0.9	-1.4	-1.3	-1.6	-1.3	-1.3
Waist circumference	0.3	1.2	1.8	-0.4	-1.0	-1.2	-1.2	-1.3	-1.2	-1.1
Had menopause	0.3	0.3	0.6	0.6	0.4	0.8	0.5	0.4	0.5	0.8
Trunk fat-free mass	0.3	1.7	2.8	-1.5	-0.7	-1.4	-1.0	-0.7	-1.7	-1.6
Number of live births	0.3	0.4	0.9	0.2	0.4	1.0	0.6	0.2	0.8	0.9
Arm fat mass (right)	0.3	1.2	2.0	-0.3	-0.8	-1.3	-1.2	-1.2	-1.4	-1.3
Trunk predicted mass	0.3	1.6	2.7	-1.5	-0.7	-1.4	-1.0	-0.6	-1.6	-1.6
Standing height	0.3	2.6	3.8	-1.9	-1.1	-2.0	-1.3	-1.0	-1.7	-1.9
Headache pain in last month	0.3	0.6	1.7	-1.3	0.5	0.3	0.3	1.3	0.6	0.2
Medication: Amlodipine	0.3	0.5	1.0	-0.1	-0.2	-0.9	-1.0	-0.6	-0.6	-0.8
Forced vital capacity (FVC), Best measure	0.3	1.2	3.0	-0.3	1.7	0.7	1.2	1.6	0.7	0.4
Arm fat-free mass (right)	0.3	1.4	2.3	-1.0	-0.8	-1.3	-0.9	-1.1	-1.5	-1.4
Angina (self-reported)	0.3	0.5	2.4	1.6	0.2	-0.3	0.1	-0.6	-0.4	-0.2
Medication: Omeprazole	0.3	0.3	1.1	1.0	0.8	0.3	0.4	0.2	0.4	0.4
Whole body fat mass	0.3	1.0	1.8	0.1	-0.7	-1.2	-1.1	-1.3	-1.1	-1.1
Arm predicted mass (right)	0.3	1.7	3.1	-1.0	-0.9	-1.5	-1.0	-1.3	-1.7	-1.6
Overall health rating	0.3	0.7	1.6	0.1	1.3	0.6	0.7	0.9	0.9	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.5	1.2	-0.2	0.3	0.2	0.0	0.4	0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.4	-1.6	0.0	-0.5	-0.5	0.1	-0.6	-0.6
Medication: Paracetamol	0.3	0.4	1.0	-0.4	1.0	0.7	0.7	0.6	0.6	0.4
Medication: Lisinopril	0.3	0.4	1.0	-1.0	0.1	-0.3	-0.2	0.6	-0.6	-0.8
Ever smoked	0.3	0.5	1.2	0.6	0.5	0.7	1.1	0.5	0.5	0.7
Arm fat-free mass (left)	0.3	1.6	2.9	-1.3	-0.8	-1.4	-1.0	-0.8	-1.7	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.5	0.7	0.6	0.5	0.5	0.5	0.7	0.7
Heart disease (siblings)	0.3	0.3	0.5	-0.2	-0.7	-0.7	-0.7	-0.6	-0.5	-0.5
Leg fat mass (left)	0.3	1.0	1.5	-0.2	-0.8	-1.1	-1.1	-1.2	-1.2	-1.1
Arm predicted mass (left)	0.3	1.5	2.8	-1.1	-0.8	-1.3	-0.9	-0.9	-1.7	-1.5
Breast Cancer	0.2	0.4	1.0	0.6	1.0	0.4	0.7	0.8	0.5	0.3
Rheumatoid Arthritis	0.2	0.3	0.6	0.1	-0.6	-0.4	-0.8	0.0	-0.7	-0.6
Blood White Count	0.2	1.3	4.8	-0.1	2.2	0.7	0.4	1.4	1.2	0.5
Lung FEV1/FVC ratio	0.2	1.0	2.3	1.3	-0.5	-0.6	-0.5	-1.5	-1.1	-0.7
Relative age of first facial hair	0.2	0.4	0.7	-0.5	-0.8	-0.4	-0.8	-0.6	-0.7	-0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	0.4	0.2	0.6	0.8	0.5	0.4	0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.0	-1.0	-0.3	-0.4	-0.2	0.2	-0.2	-0.3
Severe depression (siblings)	0.2	0.2	0.6	0.5	0.8	0.3	0.5	0.1	0.4	0.3
Relative age voice broke	0.2	0.2	0.7	-0.8	-0.1	-0.4	-0.6	0.5	-0.1	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.4	-1.2	-0.4	-0.5	-0.3	0.1	-0.8	-0.7
Qualifications: CSEs or equivalent	0.2	0.2	0.7	-0.1	-0.7	-0.2	-0.8	-0.3	-0.2	-0.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	-0.2	-0.0	0.4	0.6	0.8	0.4	0.4
Mouth/teeth dental problems	0.2	0.3	0.9	0.8	1.0	0.2	0.7	-0.3	0.2	-0.0
Time employed in main current job	0.2	0.2	0.4	-0.4	-0.5	-0.4	-0.5	-0.4	-0.7	-0.4
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	0.6	-0.2	0.6	0.1	0.7	0.7	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.7	-0.8	-0.1	-0.5	-0.1	-0.4	-0.3	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.8	-0.1	1.4	0.4	1.0	1.3	0.2	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.1	0.6	0.4	0.7	0.3	0.7	0.4
Hair/balding pattern: Pattern 4	0.2	0.6	1.2	0.8	0.1	0.9	0.9	-0.2	0.7	1.1
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	0.7	0.6	0.4	0.1	0.4	0.6	0.4
High blood pressure (siblings)	0.2	0.3	0.4	0.5	0.6	0.6	0.5	0.2	0.5	0.6
Body fat percentage	0.2	0.7	1.7	0.8	-0.6	-0.8	-0.8	-1.3	-0.7	-0.6
Comparative body size at age 10	0.2	0.5	1.5	0.8	0.9	0.5	0.4	1.2	-0.3	-0.0
Number of full brothers	0.2	0.2	0.8	-0.4	0.4	0.3	0.5	0.9	0.3	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.2	0.4	0.5	0.9	0.4	0.6	0.5
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	0.9	0.9	0.6	0.4	0.6	0.4	0.6
Age at first live birth	0.2	0.4	1.1	-1.0	0.6	0.0	-0.1	1.0	0.3	-0.1
Emphysema/chronic bronchitis	0.2	0.2	0.7	-0.5	-0.4	-0.4	-0.5	-0.8	-0.1	-0.2
Migraine (self-reported)	0.2	0.2	0.7	0.2	0.2	0.5	0.3	-0.1	0.9	0.6
Comparative height size at age 10	0.2	1.1	1.8	-0.8	-0.7	-1.3	-1.1	-1.0	-1.1	-1.2
Chest pain or discomfort	0.2	0.3	0.4	0.5	0.5	0.5	0.5	0.6	0.6	0.4
Family relationship satisfaction	0.2	0.3	0.8	0.2	0.9	0.4	0.4	0.5	0.7	0.4
Knee pain experienced in last month	0.2	0.3	1.3	1.1	0.3	0.3	0.2	-0.1	0.5	0.5
Whole body fat-free mass	0.2	0.9	1.7	-1.1	-0.4	-1.1	-0.7	-0.3	-1.3	-1.2
Diabetes diagnosed by doctor	0.2	0.4	1.7	-1.3	-0.1	-0.6	0.1	0.2	-0.3	-0.6
Medication for cholesterol	0.2	0.3	0.6	0.6	-0.7	0.3	0.6	-0.3	0.3	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.7	0.3	0.5	0.6	0.4	0.8	0.3	0.4
Osteoarthritis (self-reported)	0.2	0.3	0.8	0.9	-0.2	-0.5	-0.4	-0.7	-0.3	-0.3
Smoking status: Current	0.2	0.3	0.8	0.9	0.7	-0.3	-0.2	-0.7	-0.2	-0.4
Whole body water mass	0.2	0.9	1.8	-1.1	-0.4	-1.0	-0.7	-0.4	-1.3	-1.2
Arm fat mass (left)	0.2	1.0	1.6	-0.2	-0.6	-1.2	-1.1	-1.0	-1.3	-1.2
Average weekly champagne plus white wine intake	0.2	0.3	1.4	0.9	-0.4	-0.0	0.0	-1.2	-0.1	0.1
Eye problems/disorders: Glaucoma	0.2	0.3	1.8	1.3	-0.2	0.1	0.2	-0.4	-0.2	0.2
Medication: Blood pressure	0.2	0.4	1.1	-1.0	0.6	-0.0	-0.1	1.0	-0.1	-0.3
Medication: Bendroflumethiazide	0.2	0.3	1.0	-1.0	0.3	0.3	-0.2	0.8	0.7	0.3
Basal metabolic rate	0.2	0.9	1.8	-1.0	-0.4	-1.1	-0.8	-0.4	-1.3	-1.3
Ever depressed for a whole week	0.2	0.3	0.9	0.9	0.4	-0.2	0.4	-0.7	0.0	-0.0
Bipolar Disorder (2018)	0.1	0.1	0.2	-0.4	0.2	0.2	-0.3	-0.0	0.5	0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.4	-0.5	0.4	0.1	-0.1	-0.7	0.4	0.2
Neuroticism (Nagel 2018)	0.1	0.2	0.6	-0.4	0.4	0.4	0.4	0.3	0.8	0.6
Schizophrenia (2018)	0.1	0.1	0.7	-0.3	0.2	-0.1	0.0	-0.8	0.1	0.1
Schizophrenia (2014)	0.1	0.3	1.7	-0.2	0.4	-0.3	0.0	-1.3	-0.2	-0.2
BMI	0.1	0.5	0.9	-0.3	-0.8	-0.6	-0.7	-1.0	-0.9	-0.6
Height	0.1	1.9	4.1	-2.0	-0.1	-1.9	-0.7	-0.9	-1.1	-1.8
Systolic Blood Pressure	0.1	0.7	1.4	-0.7	-0.7	-0.9	-1.2	-0.3	-0.9	-1.1
Hair Pigment	0.1	3.1	4.3	-2.1	-1.6	-1.7	-1.6	-1.5	-1.9	-1.8
Number of treatments/medications taken	0.1	0.1	0.3	-0.5	0.3	-0.2	-0.4	0.3	0.2	-0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.6	-0.2	0.2	0.1	-0.1	0.8	-0.1	-0.0
Systolic blood pressure, automated reading	0.1	0.2	0.5	0.7	0.5	0.2	0.0	0.2	0.4	0.2
Supplements: Zinc	0.1	0.1	0.4	-0.6	0.1	-0.1	-0.2	-0.3	-0.0	-0.0
Leg fat-free mass (left)	0.1	0.3	0.6	-0.7	0.2	-0.5	-0.3	0.4	-0.8	-0.7
Current tobacco smoking	0.1	0.2	0.6	0.8	0.7	-0.3	-0.1	-0.6	-0.2	-0.3
Taking other prescription medications	0.1	0.1	0.4	-0.7	-0.3	-0.0	-0.1	0.3	0.0	0.0
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.2	-0.4	-0.2	-0.2	0.3	-0.1	-0.1
Serious illness, injury or assault to yourself	0.1	0.1	0.3	-0.5	-0.4	-0.2	-0.5	0.1	-0.2	-0.1
Supplements: Glucosamine	0.1	0.1	0.2	-0.1	-0.3	-0.1	-0.1	0.2	-0.4	-0.3
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.1	-0.4	-0.4	-0.4	-0.2	-0.3	-0.4
Had other major operations	0.1	0.2	0.5	-0.6	0.5	0.4	0.2	0.7	0.3	0.2
Forced vital capacity (FVC)	0.1	0.4	1.2	-0.8	1.1	-0.1	0.4	0.8	0.1	-0.3
Qualifications: None of the above	0.1	0.3	0.8	0.9	0.5	0.6	0.3	-0.1	0.3	0.6
Diabetes (self-reported)	0.1	0.1	0.4	-0.7	0.1	-0.3	0.3	0.4	0.0	-0.2
Illnesses of siblings	0.1	0.1	0.3	-0.5	0.1	0.3	0.4	0.5	0.2	0.1
Weight	0.1	0.7	1.4	-0.4	-0.3	-1.0	-0.8	-0.7	-1.2	-1.1
Impedance of arm (right)	0.1	0.3	0.7	0.6	0.6	0.4	0.2	0.5	0.9	0.6
Arm fat percentage (right)	0.1	0.4	0.6	0.7	-0.3	-0.5	-0.7	-0.8	-0.6	-0.5
Hair/balding pattern: Pattern 3	0.1	0.2	1.2	1.1	-0.4	0.2	0.0	0.1	0.1	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.0	-0.5	1.0	-0.1	0.4	0.8	-0.1	-0.4
Asthma	0.1	0.2	0.5	0.1	-0.7	-0.0	-0.6	-0.3	-0.3	-0.1
Medication: Lansoprazole	0.1	0.1	0.2	-0.4	0.1	-0.4	-0.0	0.2	0.1	-0.4
Illnesses of mother	0.1	0.2	0.4	-0.6	-0.5	-0.0	-0.5	0.3	-0.3	-0.2
Impedance of arm (left)	0.1	0.3	0.7	0.8	0.4	0.2	0.1	-0.1	0.8	0.5
Tense / ‘highly strung’	0.1	0.1	0.2	-0.5	0.2	0.2	0.3	0.3	0.4	0.4
Glaucoma (self-reported)	0.1	0.1	0.7	0.8	-0.3	0.1	0.0	-0.1	0.0	0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.7	-0.8	-0.7	-0.2	-0.3	0.3	-0.5	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	-0.4	-0.0	0.2	0.2	0.6	-0.0	0.1
Neck or shoulder pain in last month	0.1	0.1	0.4	-0.7	-0.4	-0.0	-0.4	0.1	0.0	-0.1
Medication: Ibuprofen	0.1	0.1	0.4	-0.5	0.6	0.1	0.3	0.2	0.2	-0.2
Medication: Allopurinol	0.1	0.2	0.3	-0.2	-0.4	-0.6	-0.4	-0.6	-0.4	-0.5
Heart disease (mother)	0.1	0.1	0.2	0.1	0.4	0.0	0.2	0.5	0.2	0.1
Suffer from ‘nerves’	0.1	0.1	0.7	-0.8	-0.2	0.1	-0.3	0.2	0.1	0.1
Arm fat percentage (left)	0.1	0.4	0.8	0.7	-0.3	-0.6	-0.7	-0.9	-0.6	-0.5
Average weekly red wine intake	0.1	0.2	0.5	-0.2	0.4	0.5	0.7	0.2	0.5	0.3
Ever had bowel cancer screening	0.1	0.1	0.1	0.1	0.2	0.2	0.3	0.3	0.4	0.2
Commuting to job workplace: Walk	0.1	0.1	0.6	0.8	-0.1	0.4	0.2	-0.2	-0.0	0.3
Asthma (self-reported)	0.1	0.2	0.6	0.1	-0.7	-0.2	-0.7	-0.4	-0.5	-0.2
Guilty feelings	0.1	0.2	0.7	0.0	-0.7	-0.3	-0.2	-0.8	-0.2	-0.0
Pain experienced in last month	0.1	0.2	0.5	0.5	0.0	-0.3	0.1	-0.7	-0.5	-0.3
Basal cell carcinoma (self-reported)	0.1	0.2	0.5	0.0	0.4	0.3	0.3	0.7	0.5	0.3
Impedance of whole body	0.1	0.6	1.6	-0.1	-0.8	-0.8	-0.8	-1.3	-0.2	-0.5
Major Depression (MDD)	0.0	0.1	0.1	0.3	-0.4	-0.1	0.0	0.0	-0.3	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.2	-0.1	-0.1	0.0
Neuroticism (2016)	0.0	0.1	0.2	0.4	-0.3	0.2	-0.1	-0.2	0.1	0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	-0.3	0.2	-0.1	0.4	0.2	0.2	0.1
Tanning	0.0	0.4	0.8	-0.5	0.9	0.2	0.5	0.8	0.7	0.3
Sensitivity / hurt feelings	0.0	0.1	0.4	0.1	-0.6	0.1	-0.1	-0.2	0.1	0.2
Hearing difficulty/problems: Yes	0.0	0.1	0.4	-0.0	-0.6	0.1	0.1	-0.2	-0.1	0.1
Fed-up feelings	0.0	0.1	0.2	-0.4	-0.0	0.0	0.0	-0.0	0.5	0.3
Body mass index (BMI)	0.0	0.2	0.5	0.3	-0.1	-0.4	-0.4	-0.5	-0.7	-0.5
Leg predicted mass (left)	0.0	0.2	0.4	-0.6	0.3	-0.4	-0.2	0.4	-0.7	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	-0.4	-0.0	-0.2	0.2	0.0	-0.4	-0.4
Hip circumference	0.0	0.1	0.3	0.5	0.3	-0.1	0.1	-0.5	-0.3	-0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.4	0.7	-0.1	-0.2	0.1	-0.5	0.1	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	0.1	-0.2	-0.3	-0.1	-0.2	-0.1	-0.1
Shortness of breath walking on level ground	0.0	0.0	0.2	-0.2	-0.1	0.1	0.1	-0.4	-0.2	-0.0
Leg fat-free mass (right)	0.0	0.2	0.4	-0.4	0.5	-0.2	0.1	0.6	-0.4	-0.4
Leg predicted mass (right)	0.0	0.2	0.3	-0.5	0.4	-0.2	0.0	0.5	-0.5	-0.4
Hearing aid user	0.0	0.1	0.2	0.3	-0.5	0.1	-0.2	-0.0	-0.1	0.1

Hub : Genes

LGALS7B

Models

Trait associations