TWAS hub - LGALS7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0838	0.0358	5.6e-16	0.077	0.094	0.094	NA	0.089	2.1e-15	1.3e-18	1.1e-18	NA	1.1e-17
2	TCGA	Lung Adenocarcinoma	0.0294	0.0147	4.0e-04	0.003	0.019	0.007	NA	0.007	1.2e-01	2.5e-03	4.5e-02	NA	4.6e-02
3	TCGA	Lung Squamous Cell Carcinoma	0.0606	0.0274	1.5e-04	0.023	0.041	0.033	NA	0.036	1.0e-03	1.8e-05	1.0e-04	NA	5.6e-05
4	TCGA	Ovarian Serous Cystadenocarcinoma	0.0530	0.0330	9.7e-03	-0.004	0.015	-0.001	NA	-0.003	8.1e-01	3.1e-02	4.1e-01	NA	5.8e-01
5	TCGA	Pheochromocytoma and Paraganglioma	0.1530	0.0890	3.1e-03	0.082	0.043	0.097	NA	0.074	3.6e-04	7.9e-03	1.1e-04	NA	7.1e-04
6	TCGA	Prostate Adenocarcinoma	0.0975	0.0352	6.9e-12	0.127	0.117	0.124	NA	0.125	3.8e-13	3.2e-12	6.1e-13	NA	5.0e-13
7	TCGA	Thyroid Carcinoma	0.0620	0.0240	7.8e-07	0.094	0.077	0.088	NA	0.091	1.9e-09	6.0e-08	6.4e-09	NA	3.3e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Chronic bronchitis/emphysema (father)	6.0	7.0	13.1	-1.9	-3.4	-2.1	-3.1	-1.6	-3.6	-2.1
Pulse rate	4.7	8.0	15.2	2.6	3.9	-1.3	1.8	3.4	2.5	3.3
Allergy or Eczema	4.3	11.3	20.3	3.6	4.5	1.6	4.0	2.1	3.8	2.9
Pain type(s) experienced in last month: Hip pain	4.3	5.4	10.5	2.0	2.2	0.6	3.1	3.2	1.8	2.3
Pulse rate, automated reading	4.0	12.8	26.7	3.7	5.2	-0.9	1.7	4.5	3.2	3.9
Hayfever, allergic rhinitis or eczema	3.5	7.5	12.7	3.1	3.6	1.0	3.4	1.3	3.2	2.3
Medication: Seretide 50 evohaler	3.1	3.6	5.9	1.7	2.4	-0.2	1.6	2.4	1.7	2.3
Birth weight of first child	3.0	5.5	8.8	-2.7	-2.6	-0.6	-1.7	-2.4	-2.6	-3.0
Depression (Nagel 2018)	2.8	4.2	8.0	-2.8	-2.8	-0.9	-1.3	-0.8	-2.5	-2.0
Loneliness, isolation	2.8	3.8	6.9	-2.6	-2.6	-1.0	-1.1	-1.6	-2.1	-2.0
Nervous feelings	2.6	4.8	8.2	2.6	2.9	0.7	2.8	1.1	2.3	2.1
Fractured/broken bones in last 5 years	2.5	3.3	5.2	-1.7	-2.3	-1.2	-1.8	-1.4	-2.2	-1.8
Alzheimer’s Disease (including proxy)	2.4	3.5	7.0	2.2	2.1	2.6	1.4	-0.1	1.9	1.6
Hayfever/allergic rhinitis (self-reported)	2.4	3.2	5.5	1.9	2.1	-0.4	2.1	1.3	1.6	2.4
Lung cancer (father)	2.4	2.9	4.3	-1.4	-2.1	-1.4	-1.6	-1.6	-2.1	-1.5
Number of children fathered	2.4	2.7	5.7	2.0	2.2	0.4	1.1	1.1	1.4	2.4
Wears glasses or contact lenses	2.4	2.8	4.7	1.7	2.2	0.2	1.7	1.5	1.9	1.8
Myopia	2.3	3.3	6.2	-1.1	-2.1	-0.9	-1.9	-2.5	-1.4	-2.2
Frequency of depressed mood in last 2 weeks	2.2	3.1	6.2	-2.0	-2.4	-0.1	-0.8	-1.2	-2.0	-2.5
Allergy	2.2	5.0	8.2	-2.7	-2.8	-1.2	-2.8	-1.2	-2.9	-1.0
Prostate Cancer	2.0	2.8	5.4	-1.7	-2.3	0.5	-0.8	-1.2	-2.0	-2.1
Alcohol drinker status: Previous	2.0	2.3	5.0	-2.2	-1.7	-1.1	-1.4	-0.9	-1.8	-1.0
Alzheimer’s Disease (in mother)	1.9	2.2	4.0	2.0	1.6	1.7	1.3	-0.5	1.4	1.5
Vitamin and mineral supplements	1.9	2.6	7.0	1.6	1.9	-1.2	0.3	1.4	1.3	2.6
Body Mass Index (BMI) (2010)	1.8	2.4	5.3	2.3	1.8	1.2	1.1	0.3	1.9	1.6
Peak expiratory flow (PEF)	1.8	4.2	5.7	2.4	2.0	2.3	2.4	0.6	1.7	2.3
Mineral and other dietary supplements	1.8	2.5	8.0	1.6	1.2	-2.0	0.5	0.7	0.8	2.8
Verbal and Numeric Reasoning (VNR)	1.7	4.0	5.7	-2.3	-2.4	-1.4	-1.7	-1.8	-2.4	-1.7
Hand grip strength (right)	1.7	4.5	8.1	1.7	2.6	0.3	2.3	2.3	1.8	2.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	5.3	-2.3	-1.7	-1.4	-1.2	0.7	-1.8	-0.9
Breast cancer (self-reported)	1.7	2.1	4.5	2.1	1.6	1.6	1.3	0.0	1.4	1.1
Commuting to job workplace: Public transport	1.7	2.0	3.6	-1.0	-1.9	-0.5	-1.6	-1.7	-1.3	-1.3
Supplements: Fish oil (including cod liver oil)	1.7	2.3	7.8	-2.0	-1.3	1.0	-0.7	-0.1	-1.0	-2.8
Depressed Affect (Nagel 2018)	1.6	3.3	5.9	-2.4	-1.9	-2.3	-1.1	-0.4	-1.9	-1.8
Worry (Nagel 2018)	1.6	3.3	5.8	1.3	2.3	-0.2	2.4	1.8	1.9	2.0
Chronotype (morning person)	1.6	3.6	5.4	1.8	2.3	2.3	1.8	0.9	2.3	1.4
Pain all over the body in last month	1.6	1.8	3.9	-1.2	-1.4	0.7	-1.0	-1.0	-1.6	-2.0
Worrier / anxious feelings	1.6	3.0	6.0	1.3	2.0	-1.1	2.4	1.8	1.5	1.6
Falls in the last year	1.6	2.2	4.2	-2.0	-2.0	0.1	-1.2	0.2	-1.9	-1.4
Happiness	1.6	2.0	5.5	2.4	1.3	-0.2	1.2	0.4	1.8	1.4
Medication: Cholesterol lowering	1.5	2.4	9.0	-0.4	0.1	-3.0	-1.8	0.7	-1.0	1.6
Exposure to tobacco smoke outside home	1.5	2.0	4.3	-1.6	-1.5	-0.3	-2.1	0.8	-1.3	-1.5
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	4.3	2.1	1.7	-0.1	0.8	0.6	1.5	1.5
Medication: Lisinopril	1.5	1.9	5.2	1.1	1.1	2.3	1.7	-0.3	1.6	0.7
Pulse wave reflection index	1.4	1.7	5.0	-0.1	-1.2	1.4	-0.5	-2.2	-1.0	-1.5
Ever highly irritable/argumentative for 2 days	1.4	1.7	3.6	-1.7	-1.3	0.5	-0.9	-0.9	-1.2	-1.9
Migraine (self-reported)	1.4	1.8	3.5	-1.9	-1.6	-1.2	-0.8	1.1	-1.5	-0.8
Leg pain on walking	1.4	1.7	3.1	-1.7	-1.6	-0.0	-1.1	0.6	-1.6	-1.8
Diastolic blood pressure, automated reading	1.4	4.4	8.2	1.9	2.9	0.4	2.3	2.2	1.7	2.4
Blood Eosinophil Count	1.3	10.2	17.3	2.6	4.2	-0.8	3.4	2.1	3.9	4.0
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	4.6	1.5	2.0	0.9	1.7	1.2	1.6	2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.0	-1.5	-1.4	-0.0	-1.3	0.1	-1.0	-1.7
Average weekly champagne plus white wine intake	1.3	1.8	5.5	-1.4	-0.9	-1.5	-2.3	-0.0	-1.5	-0.1
Illnesses of father: High blood pressure	1.3	1.6	3.4	-1.6	-1.3	-1.8	-0.1	1.7	-1.0	0.2
Intelligence (Savage-Jansen 2018)	1.2	3.7	5.9	-2.4	-2.3	-1.3	-2.0	-1.1	-2.0	-1.9
Alzheimer’s Disease (in father)	1.2	1.3	2.0	0.8	1.4	1.0	0.8	1.4	1.0	1.3
HbA1C	1.2	1.3	3.5	1.9	1.0	0.5	0.9	0.8	1.1	1.4
High blood pressure (mother)	1.2	1.7	3.6	-1.2	-1.9	-0.7	-0.7	-1.7	-1.2	-1.2
Comparative body size at age 10	1.2	3.4	10.0	1.6	2.0	3.2	1.0	-1.2	2.3	0.1
Irritability	1.2	2.0	3.7	-1.6	-1.9	-1.9	0.0	-0.3	-1.7	-1.0
Hand grip strength (left)	1.1	2.9	4.8	1.3	2.2	0.6	1.8	2.1	1.2	2.1
Medication for hormone replacement therapy	1.1	1.2	3.9	-0.3	-0.5	-1.6	-1.2	-2.0	-0.4	-0.3
Alcohol usually taken with meals	1.1	1.9	4.4	-0.9	-1.6	-0.7	-1.4	-2.1	-0.9	-1.3
Financial difficulties in last 2 years	1.1	1.4	2.7	-1.2	-1.4	1.1	0.2	-1.3	-1.0	-1.6
Fluid intelligence score	1.1	2.2	3.3	-1.8	-1.8	-0.7	-1.4	-1.5	-1.6	-1.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	6.5	-0.0	-0.3	2.5	0.6	-0.9	0.6	-2.2
Birth weight	1.1	2.4	5.1	1.5	2.3	0.0	-0.1	1.9	1.6	1.8
Chronic bronchitis/emphysema (mother)	1.1	1.3	5.2	-0.2	-0.0	-2.3	0.2	1.3	-1.0	1.0
Supplements: Vitamin C	1.1	1.3	4.0	-0.5	-1.0	0.4	-0.3	-2.0	-0.5	-1.9
Average weekly beer plus cider intake	1.1	1.6	2.7	-1.6	-1.3	-1.3	-1.4	0.4	-1.1	-1.4
Unable to work because of sickness or disability	1.1	1.4	2.9	-0.7	-1.7	0.5	-1.4	-0.6	-1.5	-1.2
Rheumatoid Arthritis	1.0	1.3	2.9	1.3	1.7	0.9	0.5	-0.5	1.7	0.6
Blood Platelet Count	1.0	11.7	30.1	4.2	5.5	0.5	-2.5	-0.2	4.6	2.6
Type 2 Diabetes (T2D) (2018)	1.0	1.8	2.8	-1.5	-1.7	-1.7	-1.2	-0.9	-1.6	-0.2
Relative age of first facial hair	1.0	2.1	4.2	2.1	1.6	1.4	1.7	-0.1	1.7	0.7
Diabetes (mother)	1.0	1.3	2.7	-0.7	-1.0	-0.2	-1.6	-1.2	-1.3	-1.2
Multivitamins +/- minerals	1.0	1.3	2.5	-1.6	-1.3	1.4	0.4	0.0	-0.8	-1.4
Medication: Atenolol	1.0	1.2	1.9	-0.7	-1.4	0.0	-1.0	-1.3	-1.4	-1.2
Hearing difficulty/problems with background noise	1.0	1.6	2.7	0.5	1.3	1.2	1.6	1.6	1.0	1.0
Medication: Ramipril	1.0	1.2	4.8	1.0	1.0	-0.9	0.8	0.1	0.4	2.2
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.9	0.0	0.1	-2.2	0.0	1.3	-0.2	2.1
Mean time to correctly identify matches	1.0	1.9	4.0	-1.0	-2.0	-0.7	-1.1	-1.8	-1.1	-1.6
Alcohol intake frequency.	1.0	2.4	6.0	-2.5	-1.9	-1.7	-0.8	-0.3	-1.4	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.8	-0.8	-0.9	-1.3	-1.1	-1.2	-1.4	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	3.4	0.7	0.8	0.1	1.4	1.0	0.4	1.8
Eye problems/disorders: Cataract	1.0	1.2	5.2	0.2	0.4	-2.3	-0.2	0.6	0.2	1.5
Commuting to job workplace: Cycle	1.0	1.3	3.1	-0.4	-1.4	0.9	-0.6	-1.8	-0.8	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	4.9	-2.2	-1.5	-0.5	-0.8	-0.2	-1.4	-0.8
Illnesses of mother	0.9	1.1	2.1	0.9	1.1	0.9	1.1	1.2	1.5	0.2
Qualifications: College or University degree	0.9	2.8	4.9	-2.2	-2.0	0.1	-0.8	-1.8	-1.8	-1.8
Number of self-reported non-cancer illnesses	0.9	1.5	3.1	0.4	1.4	-0.8	1.7	1.4	1.1	1.4
Age started oral contraceptive pill	0.9	1.1	2.2	-1.4	-1.4	-0.7	-0.6	-0.1	-0.9	-1.5
Respiratory disease	0.8	1.8	3.0	1.1	1.7	-0.8	0.7	1.7	1.4	1.4
Medication: Co-codamol	0.8	1.0	1.7	-1.1	-1.0	-0.6	-0.8	-1.0	-1.3	-0.8
Average weekly fortified wine intake	0.8	0.9	2.6	1.5	0.6	0.3	0.9	-0.5	1.6	0.5
Prospective memory result	0.8	1.0	3.5	-0.2	-0.7	0.5	-1.0	-1.0	-0.6	-1.9
Pulse wave Arterial Stiffness index	0.8	0.9	2.0	1.4	1.2	-0.5	0.9	0.4	0.7	1.2
Gout (self-reported)	0.8	1.2	4.4	0.1	0.5	-2.1	0.2	1.3	0.1	1.3
Health satisfaction	0.8	1.1	5.8	0.1	0.7	0.1	0.7	2.4	0.2	0.7
Medication: Blood pressure	0.8	1.4	5.6	-0.5	-0.0	-2.4	-0.4	0.4	-0.5	1.9
Overall health rating	0.8	1.7	3.2	-1.8	-1.4	-1.4	-1.0	0.6	-1.6	-0.9
Had major operations	0.8	1.0	2.0	1.2	1.4	0.8	-0.1	0.0	1.4	0.9
Illnesses of siblings: Diabetes	0.8	1.0	3.8	0.8	0.9	0.6	2.0	0.1	1.0	0.6
Smoking status: Previous	0.8	1.1	2.4	-1.1	-0.7	1.2	-0.1	-1.4	-0.6	-1.6
Qualifications: nursing, teaching	0.8	1.2	2.7	-0.1	0.8	1.1	1.1	1.5	0.3	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	7.5	-0.1	-0.7	2.7	0.4	-1.5	-0.3	-1.3
Alcohol drinker status: Never	0.8	1.0	4.9	-0.7	-0.6	-2.2	-0.0	0.8	-0.4	0.5
Reaction Time	0.7	1.3	3.1	-0.9	-1.8	-0.5	-1.1	-1.2	-0.9	-1.3
Crohns Disease (2012)	0.7	1.1	3.0	0.8	1.1	-0.0	1.6	0.0	0.6	1.7
Fasting Glucose	0.7	0.9	2.0	-0.1	-1.1	0.3	-0.9	-1.4	-0.5	-1.3
Waist Hip Ratio (WHR)	0.7	3.3	5.9	1.7	1.3	-1.9	2.4	1.4	1.3	2.3
Diabetes (father)	0.7	0.8	2.8	0.2	0.3	-1.7	1.2	0.2	0.3	1.2
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	2.8	-0.0	0.7	0.6	0.5	1.7	0.8	0.8
Supplements: Glucosamine	0.7	1.0	2.0	0.9	1.1	1.4	1.0	0.5	1.1	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	5.0	-2.2	-1.0	0.2	-0.0	-0.1	-0.1	-1.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.2	0.1	-0.2	-1.5	-0.8	-0.8	-1.1	1.0
Length of working week for main job	0.7	0.8	2.6	-0.2	0.6	1.1	0.8	1.6	0.6	0.6
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.0	0.1	1.1	-0.3	1.2	1.4	0.8	1.1
Pulse wave peak to peak time	0.7	0.9	1.9	-1.4	-1.3	0.2	-0.8	-0.4	-0.9	-1.0
Eye problems/disorders: None of the above	0.7	0.8	3.9	0.5	0.1	2.0	0.0	-0.6	0.7	-0.6
Emphysema/chronic bronchitis	0.7	0.8	4.3	-0.3	-0.6	-2.1	-0.4	-0.2	-0.6	0.1
Medication for pain relief, constipation, heartburn	0.7	1.2	2.8	1.7	1.3	0.2	0.9	0.8	1.1	1.0
Number of full sisters	0.7	0.8	3.0	-0.0	0.4	0.7	1.2	1.7	0.8	0.3
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.6	-0.4	-1.3	-1.2	-1.1	-0.7	-0.8	-0.7
Medication: Bendroflumethiazide	0.7	1.0	2.8	-1.2	-1.2	-1.7	0.0	-0.7	-0.7	-0.5
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.8	0.8	1.0	0.4	0.8	1.3	0.8	0.6
HDL Cholesterol	0.6	1.0	2.9	-0.8	-1.5	0.6	-0.5	-0.9	-0.3	-1.7
Triglycerides	0.6	0.9	2.5	0.8	1.5	-0.4	0.1	0.2	0.9	1.6
Hypothyroidism (self reported)	0.6	1.3	3.5	0.9	1.4	-0.2	1.9	0.9	1.0	1.0
Townsend deprivation index at recruitment	0.6	0.9	1.8	-0.7	-1.4	0.5	-0.6	-1.1	-0.7	-1.3
Age when periods started (menarche)	0.6	1.4	2.9	0.6	1.4	0.7	1.1	1.4	0.9	1.7
Number of incorrect matches in round	0.6	1.1	2.1	-0.7	-1.3	-1.3	-1.0	-0.4	-0.6	-1.5
Past tobacco smoking	0.6	1.0	1.9	1.1	0.9	-0.9	0.2	1.2	0.8	1.4
Hair/balding pattern: Pattern 2	0.6	0.7	2.7	-0.7	-0.8	0.5	-0.1	-1.7	-0.4	-0.8
Qualifications: None of the above	0.6	1.3	2.4	1.1	1.6	1.4	1.1	0.5	1.4	-0.4
Heart attack	0.6	0.8	2.4	0.7	0.7	-0.6	0.2	1.2	-0.3	1.5
Neuroticism score	0.6	1.2	3.4	-0.1	0.9	-1.6	1.8	1.1	0.3	0.6
Noisy workplace	0.6	0.7	1.9	-0.8	-1.0	0.3	-0.6	-0.7	-0.6	-1.4
Asthma	0.6	1.1	2.6	1.1	1.5	0.1	0.7	1.2	1.6	0.2
Loud music exposure frequency	0.6	0.6	1.2	-1.1	-0.5	-0.8	-1.0	0.3	-0.5	-1.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.4	1.4	1.2	0.4	1.6	-0.5	1.0	0.4
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.7	-0.6	-0.9	-1.0	-1.2	-1.3	-0.4	-0.5
Worry too long after embarrassment	0.6	1.1	3.5	0.6	1.2	-0.4	1.9	1.1	0.7	0.6
Shortness of breath walking on level ground	0.6	0.7	3.5	0.3	0.7	0.8	0.3	1.9	0.6	0.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	3.6	-0.3	0.7	0.3	0.3	1.9	0.2	0.7
Knee pain experienced in last month	0.6	0.9	2.3	-1.0	-1.0	-0.2	-1.5	0.7	-1.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	4.0	0.9	0.7	0.7	2.0	0.3	0.8	0.7
Back pain experienced in last month	0.6	0.9	1.7	-1.3	-0.9	0.0	-0.7	1.2	-1.0	-0.9
Ever taken oral contraceptive pill	0.6	0.7	1.9	-0.1	0.0	-1.2	0.2	1.3	-0.1	1.4
Mother’s age at death	0.6	0.7	1.3	1.1	1.0	0.2	1.1	0.3	0.9	0.7
High cholesterol (Self-reported)	0.6	1.0	2.1	0.0	0.1	-1.4	-1.5	0.5	-0.9	1.3
Ever smoked	0.6	1.1	5.8	-0.0	0.3	2.4	1.0	-0.6	0.5	-0.5
Risk taking	0.6	0.8	1.4	-1.2	-1.0	-0.6	-0.8	0.5	-0.9	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.5	-0.9	-0.6	-1.0	-0.4	-1.2	-0.7	-0.7
Irritable Bowel Disease (IBD)	0.5	1.1	2.5	1.4	0.9	-0.2	1.6	-0.4	0.6	1.5
Ovarian Cancer	0.5	0.6	1.3	0.9	0.9	0.1	0.9	-0.3	1.1	0.6
Age at First Birth	0.5	0.7	1.4	1.0	0.8	-0.3	0.1	-1.0	1.2	0.7
LDL Cholesterol	0.5	0.8	2.0	-0.1	-0.7	0.2	-1.1	-1.4	-0.7	-1.3
Neuroticism (2016)	0.5	0.7	1.6	1.3	1.1	0.5	1.1	0.2	0.9	-0.2
Primary Biliary Cirrhosis	0.5	0.7	1.5	1.2	0.9	-0.2	0.7	1.0	0.5	1.0
Neuroticism	0.5	1.2	3.5	-0.9	0.5	-1.5	1.0	1.9	-0.2	0.5
Average weekly spirits intake	0.5	0.6	1.3	0.4	0.8	0.8	-0.1	0.8	1.1	0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.0	-0.3	-0.8	-0.7	-0.8	-1.0	-1.0	-0.6
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.2	1.1	0.8	0.4	0.8	-1.0	0.8	0.0
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	1.0	1.0	-0.2	1.1	0.2	0.7	0.6
Fed-up feelings	0.5	1.0	5.1	-0.6	-0.7	-2.2	-0.1	-0.0	-0.8	-0.4
Medication: Simvastatin	0.5	0.7	2.1	0.3	0.2	-1.4	-0.6	0.4	0.4	1.4
Alcohol intake versus 10 years previously	0.5	0.7	1.8	-0.9	-1.0	-0.6	-0.7	-0.4	-0.5	-1.3
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.9	-1.0	-1.1	-1.4	-1.2	-0.8	-1.3	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	8.6	0.7	0.2	2.9	1.0	-0.9	0.5	-0.1
Impedance of arm (left)	0.5	2.1	8.0	-0.2	-1.3	-2.8	-1.0	-1.9	-0.4	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.7	0.1	0.4	1.6	0.9	0.1	0.5	-0.1
Medication: Omeprazole	0.5	0.6	2.6	-0.3	-0.4	-0.7	-0.6	-1.6	-0.4	-0.4
Chest pain or discomfort	0.5	0.7	1.7	-1.3	-0.8	-0.3	-1.3	0.1	-0.6	-0.5
Long-standing illness, disability or infirmity	0.5	0.7	1.4	-1.2	-1.0	-0.7	-0.6	-0.1	-1.1	-0.8
Diabetes diagnosed by doctor	0.5	0.9	1.7	-1.0	-1.2	-1.3	-0.5	-0.5	-1.1	0.4
Medication for cholesterol	0.5	0.8	2.1	-0.9	-0.5	-0.2	-1.2	1.5	-1.0	-0.4
Asthma (self-reported)	0.5	1.0	2.3	1.1	1.4	0.0	0.6	1.0	1.5	0.3
Illnesses of father: None of the above (group 1)	0.5	0.6	2.3	0.5	0.6	1.5	0.2	-0.7	0.6	-0.6
Hearing aid user	0.5	0.6	2.4	0.5	0.6	0.3	0.4	-1.6	0.9	-0.1
Financial situation satisfaction	0.5	0.6	2.2	-0.1	-0.7	0.8	-0.3	-1.5	-0.7	-0.7
Tinnitus: Yes, now most or all of the time	0.5	0.5	2.4	0.1	-0.5	-0.1	-0.5	-1.6	-0.4	-0.8
Medication: Paracetamol	0.5	0.8	3.3	-0.4	-0.1	1.8	0.7	1.0	0.5	-0.5
Medication: Atorvastatin	0.5	0.6	1.7	0.2	0.8	-0.9	-0.8	0.5	-0.2	1.3
Ever depressed for a whole week	0.5	0.6	1.7	-0.4	-0.7	-0.4	-1.0	-1.0	-1.3	0.0
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.1	0.6	0.6	-0.6	0.3	1.1	-0.3	1.4
Neuroticism (Nagel 2018)	0.4	1.0	3.3	-1.2	-0.7	-1.8	0.0	0.4	-0.9	-0.7
Ulcerative Colitis (UC)	0.4	0.7	1.3	0.8	0.8	0.2	1.1	-0.5	0.9	1.1
Blood Red Count	0.4	3.5	11.9	0.9	1.9	-0.4	3.5	1.3	0.7	2.4
Heel T-Score	0.4	3.2	6.9	1.1	2.4	0.4	2.6	0.9	1.2	2.5
Lung FEV1/FVC ratio	0.4	1.8	4.9	1.3	2.2	1.3	-0.2	0.9	1.7	0.9
Medication: Metformin	0.4	0.6	1.5	-0.4	-0.7	-1.1	0.6	0.6	-0.5	1.2
Maternal smoking around birth	0.4	0.6	2.1	0.3	0.3	-1.5	-0.7	0.6	-0.2	1.1
Serious illness, injury or assault to yourself	0.4	0.4	1.9	-0.1	-0.1	-1.0	0.2	1.4	-0.3	0.2
Diabetes (self-reported)	0.4	0.6	1.3	-0.5	-1.1	-1.1	-0.5	-0.9	-0.9	0.1
Impedance of arm (right)	0.4	1.7	5.2	0.1	-1.0	-2.3	-0.5	-2.2	-0.1	-0.7
Depression (self-reported)	0.4	0.4	1.3	-0.2	-1.1	0.8	0.3	0.1	-0.8	-0.6
Exposure to tobacco smoke at home	0.4	0.4	1.4	-0.1	-0.7	1.2	-0.5	0.0	-0.3	-0.9
Blood clot in the leg (DVT)	0.4	0.5	1.4	-0.6	-0.9	0.5	-0.4	0.3	-0.5	-1.2
Medication: Paracetamol	0.4	0.6	1.5	-1.1	-0.7	1.2	0.1	0.1	-0.1	-1.0
Suffer from ‘nerves’	0.4	0.6	2.2	0.1	0.7	0.4	1.5	0.8	0.7	-0.1
Medication: Aspirin	0.4	0.5	1.0	-0.6	-0.6	-0.3	-0.7	-0.6	-0.8	-1.0
Mood swings	0.4	0.7	1.5	-0.8	-1.0	-1.2	-0.2	-0.5	-0.7	-1.1
Friendships satisfaction	0.4	0.5	1.2	1.1	0.1	-1.1	0.2	0.3	0.5	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.5	0.1	0.1	1.1	0.0	-1.2	0.4	-0.4
Osteoporosis (self-reported)	0.4	0.5	1.4	-0.4	-0.6	-0.2	-0.2	-1.2	0.2	-1.2
Miserableness	0.4	0.7	1.2	-0.6	-0.6	-1.1	-0.9	-0.7	-0.8	-1.0
Medication: Blood pressure	0.4	0.9	2.6	0.6	0.8	0.9	1.6	-0.8	1.0	0.2
Schizophrenia (2018)	0.3	0.6	1.2	-0.4	-0.9	-1.0	-0.2	0.9	-1.1	-0.2
Schizophrenia vs Biploar Disorder	0.3	0.4	1.3	0.1	0.2	-1.1	-0.3	0.2	-0.6	1.1
Coronary Artery Disease (CAD)	0.3	0.4	1.3	0.2	0.9	-0.4	0.0	0.5	0.3	1.1
Mean Putamen Volume	0.3	0.3	0.7	-0.7	-0.2	-0.8	-0.5	0.3	-0.8	0.0
Lupus	0.3	0.4	1.0	0.5	0.5	0.2	0.8	1.0	0.7	0.4
Schizophrenia (2014)	0.3	0.6	1.1	-0.1	-0.9	-0.8	-0.6	1.1	-1.0	0.1
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.9	-0.4	-0.6	-1.0	0.3	-0.5	-0.6	-0.3
Smoking Status	0.3	0.7	1.5	-0.5	-0.8	1.1	-0.4	-1.0	-0.2	-1.2
Cardiovascular Disease	0.3	1.0	2.4	0.4	1.0	0.2	1.2	1.6	0.6	1.3
Number of treatments/medications taken	0.3	0.5	1.1	-1.1	-1.0	-0.7	-0.3	-0.5	-0.7	0.0
Hearing difficulty/problems: Yes	0.3	0.5	1.3	0.9	0.5	1.1	1.0	0.5	0.3	-0.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.0	0.5	-0.2	-1.0	0.6	-0.4	-0.4	0.2
Impedance of leg (right)	0.3	1.5	4.7	1.2	0.6	-2.2	1.0	0.5	0.5	1.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.0	0.5	1.0	0.4	1.0	0.0	0.6	0.2
Qualifications: CSEs or equivalent	0.3	0.4	1.1	0.2	1.0	-0.4	0.3	1.0	0.8	0.4
Medication: Levothyroxine sodium	0.3	0.5	1.1	1.0	0.7	-0.2	0.9	-1.0	0.4	0.4
Had menopause	0.3	0.4	1.2	0.6	0.3	0.5	0.3	-1.1	0.5	-0.6
Illnesses of siblings	0.3	0.4	0.9	0.0	0.7	0.9	0.8	0.1	0.8	-0.2
Father’s age at death	0.3	0.4	0.9	0.1	0.9	-0.4	0.6	0.7	0.6	0.8
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	4.8	0.5	0.1	2.2	0.8	-0.5	0.4	0.2
Medication: Lansoprazole	0.3	0.4	1.0	-0.5	-0.9	-0.4	0.0	1.0	-0.7	0.1
Hair/balding pattern: Pattern 4	0.3	0.7	1.1	-0.6	-0.7	-0.5	-1.0	1.0	-1.1	-0.9
Headache pain in last month	0.3	0.6	2.8	-1.7	-0.7	0.6	0.1	0.5	-0.2	-0.4
Glaucoma (self-reported)	0.3	0.3	0.7	0.8	0.1	-0.8	-0.6	-0.9	0.2	-0.1
Medication: Amlodipine	0.3	0.4	2.2	-0.0	-0.1	-1.5	-0.4	-0.4	-0.3	0.7
Forced vital capacity (FVC), Best measure	0.3	1.0	4.8	0.2	-0.7	2.2	0.7	-1.1	-0.1	-0.6
Number of full brothers	0.3	0.3	1.3	0.0	-0.8	1.1	-0.0	0.3	-0.4	-0.3
Neck or shoulder pain in last month	0.3	0.4	1.5	-1.0	0.4	-0.0	0.5	1.2	0.3	-0.0
Medication: Ibuprofen	0.3	0.4	1.7	0.6	-0.1	1.3	0.6	-0.2	0.5	0.0
Medication: Allopurinol	0.3	0.4	1.4	-0.5	-0.3	-1.2	-0.7	-0.4	-0.4	0.3
Family relationship satisfaction	0.3	0.4	1.2	0.1	-1.1	-0.7	-0.4	-0.5	-0.5	-0.5
Average weekly red wine intake	0.3	0.4	1.4	0.1	-0.8	0.8	-0.2	-1.2	-0.1	-0.4
Commuting to job workplace: Walk	0.3	0.3	1.1	0.7	0.4	1.1	0.2	0.2	0.2	-0.3
Pain experienced in last month	0.3	0.5	1.7	1.3	0.2	0.3	0.3	-1.2	0.4	0.3
Supplements: Calcium	0.3	0.4	1.1	-0.4	0.0	-0.3	1.1	-0.2	0.4	-0.9
Impedance of whole body	0.3	1.3	7.6	0.4	-0.5	-2.8	-0.1	-1.1	-0.0	0.4
Bipolar Disorder or Schizophrenia	0.2	0.5	1.5	-0.3	-1.0	-0.8	-0.0	1.2	-0.7	-0.3
Crohns Disease (2017)	0.2	0.5	1.2	0.9	-0.0	-0.9	0.5	-0.2	-0.6	1.1
Major Depression (MDD)	0.2	0.3	1.0	0.2	0.5	1.0	0.6	0.0	0.3	0.2
Breast Cancer	0.2	0.6	1.8	0.2	-0.7	1.1	-0.4	-1.3	-0.4	-0.4
Ulcerative Colitis	0.2	0.4	0.8	-0.1	0.8	-0.2	0.9	-0.1	0.5	0.9
Blood White Count	0.2	1.4	5.5	-0.9	-1.5	-0.5	-0.7	-2.4	-0.3	-0.8
BMI	0.2	0.9	3.0	0.2	1.1	1.0	0.4	1.7	0.5	0.8
Lung FVC	0.2	1.2	3.4	-1.0	-0.8	1.9	-0.9	-1.0	-0.3	-1.3
Sensitivity / hurt feelings	0.2	0.3	1.3	-0.1	0.4	-0.5	0.6	1.1	-0.1	-0.2
Angina	0.2	0.3	1.3	0.3	0.3	-0.4	-1.1	-0.5	0.1	0.3
Supplements: Zinc	0.2	0.2	0.8	-0.6	-0.0	-0.1	0.9	0.1	-0.3	-0.0
Pack years adult smoking proportion	0.2	0.3	0.9	0.2	0.9	0.2	0.2	0.5	0.6	0.8
Taking other prescription medications	0.2	0.3	1.2	0.4	0.3	-0.6	1.1	-0.0	0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.9	0.4	0.9	0.8	0.7	-0.1	0.8	0.7
Stomach or abdominal pain in last month	0.2	0.2	0.5	0.1	0.2	-0.4	0.7	0.4	0.6	0.6
Impedance of leg (left)	0.2	1.1	3.9	1.0	0.6	-2.0	0.9	-0.0	0.4	1.3
Mouth/teeth dental problems	0.2	0.3	1.1	0.8	-0.2	1.0	-0.6	-0.5	0.1	-0.1
Trunk fat-free mass	0.2	0.9	2.6	0.6	0.8	1.1	0.8	0.8	-0.2	1.6
Time employed in main current job	0.2	0.3	0.8	0.6	0.3	-0.9	-0.4	0.3	0.2	0.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.1	0.5	-0.7	-0.8	0.9	0.1	-0.2
Arm fat mass (right)	0.2	0.6	1.9	0.6	1.1	0.5	0.2	0.9	0.2	1.4
Trunk predicted mass	0.2	0.9	2.5	0.6	0.8	1.2	0.9	0.8	-0.2	1.6
Breastfed as a baby	0.2	0.2	0.9	-0.3	-0.1	0.2	-0.6	0.2	-0.1	0.9
Tense / ‘highly strung’	0.2	0.3	1.3	-0.0	0.1	-0.8	1.1	-0.3	-0.1	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	0.0	-0.7	-0.0	0.3	-0.9	-0.7	-0.5
High blood pressure (siblings)	0.2	0.3	1.0	-0.3	-1.0	-0.0	-0.5	-0.2	-0.8	-0.5
Leg fat percentage (right)	0.2	0.9	2.6	0.5	0.9	-0.2	-0.4	1.6	-0.1	1.5
Arm fat-free mass (right)	0.2	0.8	2.2	0.2	0.7	0.9	0.4	1.2	-0.5	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.7	-0.1	-0.2	0.6	0.8	-0.1	-0.2	-0.5
Angina (self-reported)	0.2	0.2	1.2	0.2	0.3	-0.5	-1.1	-0.3	-0.0	0.3
Leg fat mass (right)	0.2	0.7	2.4	0.3	0.6	-0.1	-0.2	1.6	-0.2	1.5
Arm predicted mass (right)	0.2	0.9	2.8	0.4	0.9	1.0	0.4	1.3	-0.3	1.7
Age at last live birth	0.2	0.4	0.6	-0.6	-0.8	0.7	0.6	-0.5	0.4	-0.6
Hypertension (Self-reported)	0.2	0.5	1.7	-0.2	0.5	-0.8	1.3	-0.0	0.3	0.9
Illnesses of father: Heart disease	0.2	0.3	1.0	0.2	0.3	-1.0	0.6	0.2	-0.1	0.7
Medication: Gliclazide	0.2	0.3	1.1	-0.0	-0.4	0.3	0.6	-1.1	0.3	0.4
Guilty feelings	0.2	0.3	1.0	-0.7	0.1	-1.0	0.0	-0.3	-0.6	0.1
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	0.7	0.5	-0.1	-0.7	-0.7	0.2	-0.0
Arm fat-free mass (left)	0.2	1.3	2.8	0.6	1.1	1.5	0.9	1.1	0.1	1.7
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.9	0.9	-0.2	1.4	-0.0	-0.5	0.5	-0.8
Basal cell carcinoma (self-reported)	0.2	0.3	0.6	-0.7	-0.7	-0.2	-0.4	-0.7	-0.2	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.7	-0.3	-0.5	0.6	-0.1	0.4	-0.1	-0.8
Pack years of smoking	0.2	0.3	0.9	0.2	0.8	-0.2	0.2	0.4	0.4	0.9
Arm predicted mass (left)	0.2	1.2	2.7	0.5	1.1	1.6	0.7	1.2	-0.0	1.6
Bipolar Disorder (2018)	0.1	0.2	0.7	0.2	-0.3	-0.3	0.4	0.8	0.2	-0.2
Height	0.1	2.4	5.2	-0.4	-1.4	-2.0	0.2	-1.8	-2.3	1.4
Systolic Blood Pressure	0.1	0.6	1.4	0.9	0.7	0.4	0.9	0.1	1.2	0.9
Hair Pigment	0.1	3.0	4.9	1.4	1.8	1.0	1.9	2.2	1.7	1.8
Tanning	0.1	1.0	2.8	-1.7	-1.4	-0.9	-0.6	0.3	-1.0	-0.5
Severe depression (siblings)	0.1	0.1	0.5	-0.7	-0.4	0.1	-0.3	-0.2	-0.1	-0.4
Leg fat-free mass (left)	0.1	0.3	1.0	0.1	0.2	1.0	0.1	0.4	-0.2	0.7
Trunk fat percentage	0.1	0.5	1.2	0.3	0.3	-1.1	-0.8	0.1	-0.4	1.0
Current tobacco smoking	0.1	0.1	0.7	-0.3	-0.1	0.2	-0.8	0.3	0.0	0.2
Relative age voice broke	0.1	0.2	1.0	-0.2	-0.0	-0.5	0.2	-1.0	0.3	0.3
High blood pressure	0.1	0.4	1.4	-0.6	0.2	-1.2	0.7	0.1	-0.1	0.8
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	-0.2	-0.2	0.6	0.4	-0.4	0.2	-0.4
Sitting height	0.1	0.9	2.9	1.2	0.6	-0.5	1.2	-0.4	-0.3	1.7
Body mass index (BMI)	0.1	0.5	1.3	0.0	0.7	1.1	-0.3	1.0	0.0	0.6
Trunk fat mass	0.1	0.5	1.8	0.2	0.3	-0.9	-0.7	0.5	-0.6	1.3
Waist circumference	0.1	0.5	1.4	0.6	0.8	-0.2	0.3	1.1	0.1	1.2
Had other major operations	0.1	0.1	0.2	-0.4	0.0	0.3	0.4	0.4	0.3	-0.3
Forced vital capacity (FVC)	0.1	0.5	2.5	0.1	-0.4	1.6	0.8	-0.5	0.1	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.6	0.3	0.6	0.8	0.5	-0.1	0.2	0.3
Weight	0.1	0.4	1.4	0.4	0.6	0.8	0.1	0.7	-0.2	1.2
Arm fat percentage (right)	0.1	0.2	0.8	-0.2	0.3	-0.3	-0.9	0.5	-0.3	0.5
Number of live births	0.1	0.2	0.7	0.3	-0.2	0.3	0.3	-0.2	0.0	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.1	-0.2	-0.4	0.0	-0.5	-0.1	0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	-0.4	-0.1	-0.7	0.0	-0.6	-0.3	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.3	0.4	-0.4	0.6	0.3	-0.3	0.0	0.5
Standing height	0.1	1.1	3.3	1.1	0.3	-0.8	1.2	-0.6	-0.4	1.8
Body fat percentage	0.1	0.4	1.1	0.0	0.1	-0.9	-1.0	0.4	-0.6	0.7
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	0.1	0.5	0.3	0.1	-0.7	0.5	-0.4
Age at first live birth	0.1	0.2	0.5	-0.3	-0.6	0.1	0.5	-0.6	0.7	-0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.6	0.0	-0.8	-0.4	0.2	-0.1	-0.3	-0.4
Heart disease (mother)	0.1	0.2	0.7	-0.8	-0.3	-0.2	-0.0	-0.4	-0.4	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	0.0	0.5	-0.5	-0.1	0.1	-0.0	0.5
Whole body fat mass	0.1	0.4	1.3	0.1	0.3	-0.6	-0.6	0.6	-0.6	1.1
Comparative height size at age 10	0.1	0.7	2.4	0.7	0.2	-1.6	0.3	0.1	-0.4	1.2
Whole body fat-free mass	0.1	0.6	1.6	0.4	0.6	1.1	0.5	0.7	-0.3	1.3
Leg fat-free mass (right)	0.1	0.3	1.8	-0.1	0.1	1.4	0.1	0.1	-0.2	0.4
Arm fat percentage (left)	0.1	0.3	0.9	-0.1	0.2	-0.5	-1.0	0.5	-0.3	0.6
Ever had bowel cancer screening	0.1	0.2	0.8	-0.2	-0.3	-0.2	0.2	-0.9	-0.2	-0.3
Osteoarthritis (self-reported)	0.1	0.2	0.4	0.6	0.1	-0.7	-0.4	0.0	-0.5	0.3
Medication: Aspirin	0.1	0.2	0.7	-0.1	-0.2	0.5	-0.3	-0.5	-0.1	-0.8
Smoking status: Current	0.1	0.1	0.7	-0.1	0.1	0.2	-0.8	0.3	0.2	0.3
Whole body water mass	0.1	0.6	1.6	0.4	0.6	1.2	0.5	0.7	-0.3	1.3
Leg predicted mass (right)	0.1	0.3	1.8	-0.0	0.2	1.3	0.1	0.1	-0.2	0.5
Arm fat mass (left)	0.1	0.5	1.6	0.5	0.9	0.4	-0.0	0.8	0.1	1.3
Basal metabolic rate	0.1	0.6	1.7	0.4	0.6	1.1	0.4	0.8	-0.2	1.3
Leg fat percentage (left)	0.1	0.5	1.5	0.3	0.7	-0.1	-0.6	1.1	-0.2	1.2
Number of operations (self-reported)	0.1	0.2	0.8	0.3	0.4	0.2	0.3	0.1	0.4	0.9
Cholesterol lowering medication	0.1	0.2	1.0	0.3	0.3	0.3	0.2	-0.0	0.2	1.0
Heart disease (siblings)	0.1	0.1	0.3	0.6	0.1	-0.3	0.0	0.4	-0.1	0.5
Leg fat mass (left)	0.1	0.4	1.4	0.2	0.5	0.0	-0.3	1.1	-0.3	1.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Systolic blood pressure, automated reading	0.0	0.1	0.4	-0.1	-0.6	0.2	-0.5	-0.4	-0.2	-0.3
Leg predicted mass (left)	0.0	0.2	0.8	-0.1	0.1	0.9	-0.1	0.4	-0.4	0.6
Hip circumference	0.0	0.1	0.3	0.2	-0.0	0.5	-0.5	-0.0	-0.5	0.2

Hub : Genes

LGALS7

Models

Trait associations