Hub : Genes

AC093388.3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1070	0.0460	3.1e-03	0.010	NA	0.066	NA	0.078	5.1e-02	NA	1.0e-05	NA	1.8e-06
2	GTEx	Esophagus Mucosa	0.1440	0.0470	7.8e-05	0.089	NA	0.096	NA	0.098	1.5e-06	NA	5.9e-07	NA	4.2e-07
3	GTEx	Heart Left Ventricle	0.0932	0.0445	8.4e-03	-0.004	NA	-0.005	NA	-0.005	5.8e-01	NA	7.2e-01	NA	9.1e-01
4	GTEx	Liver	0.3870	0.1380	5.8e-03	0.001	NA	0.037	NA	0.040	2.9e-01	NA	3.3e-02	NA	2.8e-02
5	GTEx	Muscle Skeletal	0.0439	0.0204	5.1e-03	0.011	NA	-0.001	NA	0.004	2.8e-02	NA	3.8e-01	NA	1.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.1	0.1	0.6	0.8	0.2	-0.1	-0.2	-0.2
Bipolar Disorder or Schizophrenia	0.2	0.5	0.8	0.8	-0.4	0.9	-0.9	0.2
Depressed Affect (Nagel 2018)	0.3	0.7	1.3	1.1	-0.8	0.7	0.7	0.7
Depression (Nagel 2018)	0.4	0.7	2.0	0.2	-0.0	1.4	-1.1	0.3
Intelligence (Savage-Jansen 2018)	0.8	2.4	3.6	1.8	-1.9	0.8	-1.0	1.9
Neuroticism (Nagel 2018)	0.2	0.5	1.1	1.1	-0.6	0.5	-0.9	0.5
Schizophrenia (2018)	0.3	0.6	1.6	0.4	-0.6	1.3	-0.9	0.4
Schizophrenia vs Biploar Disorder	0.7	0.9	1.1	1.0	-0.9	0.6	-1.1	1.0
Worry (Nagel 2018)	0.4	0.9	3.2	0.2	-0.3	-1.0	-1.8	0.1
Alzheimer’s Disease (in mother)	1.0	1.2	2.8	0.0	1.6	0.6	0.4	-1.7
Alzheimer’s Disease (in father)	0.9	0.9	1.7	-0.3	1.3	-1.2	0.6	-1.0
Alzheimer’s Disease (including proxy)	0.6	0.8	1.7	0.4	1.3	0.0	0.9	-1.2
Crohns Disease (2017)	0.5	1.1	2.6	-1.2	1.0	1.6	0.2	-0.2
Irritable Bowel Disease (IBD)	0.4	1.0	2.0	-1.0	0.9	1.4	1.0	-0.2
Ulcerative Colitis (UC)	0.3	0.6	2.7	-0.2	0.2	0.5	1.6	0.3
Major Depression (MDD)	0.5	0.6	1.5	-0.2	0.5	1.2	-1.0	-0.5
Reaction Time	0.3	0.5	1.8	0.6	-0.5	1.3	-0.6	-0.0
Verbal and Numeric Reasoning (VNR)	1.0	2.4	3.8	1.9	-1.9	1.1	-0.0	1.9
Breast Cancer	0.1	0.1	0.3	-0.5	-0.0	-0.3	-0.6	-0.2
Ovarian Cancer	0.2	0.3	1.0	-1.0	-0.3	-0.3	0.1	0.4
Prostate Cancer	3.7	5.2	8.9	3.0	-2.5	1.1	1.0	3.0
Age at First Birth	0.3	0.5	1.4	-1.2	-0.7	0.4	-0.1	0.7
Bipolar Disorder (2011)	1.5	1.4	2.3	-1.3	1.5	0.8	0.3	-1.5
Body Mass Index (BMI) (2010)	0.8	1.1	3.1	-0.5	-0.4	1.3	1.8	0.4
Coronary Artery Disease (CAD)	2.2	2.6	6.3	0.3	-1.7	2.5	1.1	1.6
Crohns Disease (2012)	0.5	0.9	1.8	0.1	-0.8	1.3	0.5	1.3
Mean Putamen Volume	0.2	0.3	1.2	-0.1	-0.1	-1.1	0.2	0.1
Fasting Glucose	0.3	0.4	1.2	-0.0	0.5	-0.2	1.1	-0.5
HbA1C	0.3	0.3	0.7	-0.3	0.9	0.0	-0.6	-0.6
HDL Cholesterol	0.7	1.2	2.8	-1.7	1.0	-0.5	-0.8	-1.0
LDL Cholesterol	0.6	0.9	1.5	-0.6	1.2	-1.2	0.1	-1.1
Lupus	3.4	5.2	9.1	1.4	-2.5	3.0	-2.0	2.0
Neuroticism (2016)	0.6	0.9	3.7	0.8	-0.1	0.3	-1.9	0.3
Primary Biliary Cirrhosis	1.9	2.7	6.9	1.5	-1.3	2.6	-0.8	1.3
Rheumatoid Arthritis	1.9	2.6	7.3	-1.4	0.8	2.7	1.2	-1.1
Schizophrenia (2014)	0.4	0.9	2.7	0.8	-0.7	1.6	-0.7	0.7
Triglycerides	0.6	1.0	4.4	-0.4	0.1	-0.6	2.1	-0.4
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.4	0.5	-0.5	1.8	0.7	-0.2
Ulcerative Colitis	0.3	0.4	1.1	0.2	-0.5	-0.4	1.0	0.7
Blood Eosinophil Count	0.1	1.1	3.8	0.4	-0.0	-1.3	1.9	-0.1
Blood Platelet Count	0.4	4.8	9.8	1.5	-1.5	-2.6	3.1	1.6
Blood Red Count	0.1	1.4	3.6	-1.9	0.2	-1.6	-0.9	-0.1
Blood White Count	0.0	0.0	0.1	-0.2	0.1	-0.0	-0.1	-0.4
Heel T-Score	0.5	4.3	8.7	1.3	-3.0	-0.5	2.1	2.5
BMI	0.0	0.1	0.2	0.0	-0.5	0.4	0.2	0.1
Height	0.3	6.4	14.4	0.8	-2.2	-0.5	-3.8	3.4
Waist Hip Ratio (WHR)	0.4	1.6	2.7	-1.0	1.5	0.1	1.4	-1.6
Systolic Blood Pressure	0.6	3.0	10.6	-1.5	-0.2	-3.3	1.4	0.3
Smoking Status	0.3	0.7	1.7	0.1	1.3	0.4	0.5	-1.1
Allergy or Eczema	1.9	5.1	10.3	1.3	-3.2	1.8	-0.1	3.2
Cardiovascular Disease	0.3	1.0	1.9	0.5	-1.3	-0.7	0.5	1.4
Hypothyroidism (self reported)	2.2	5.1	9.7	1.7	-1.3	3.1	-3.0	1.4
Respiratory disease	1.6	3.6	5.5	2.0	-1.9	1.0	2.3	2.0
Type 2 Diabetes (T2D) (2018)	1.0	1.9	6.2	-1.3	0.0	2.5	-1.0	-0.8
Lung FEV1/FVC ratio	0.1	0.5	1.7	-1.3	-0.4	0.5	0.5	0.0
Lung FVC	0.9	4.7	9.9	0.4	-2.5	-3.1	0.2	2.6
Neuroticism	0.3	0.7	2.0	0.7	-0.8	-0.5	-1.4	0.6
Chronotype (morning person)	1.3	3.0	6.4	2.5	-1.7	-1.9	0.2	1.5
Hair Pigment	0.2	4.8	10.1	-0.1	2.9	-0.6	-3.2	-2.3
Tanning	0.0	0.6	1.6	1.3	-0.8	0.1	-0.5	0.7
Hand grip strength (left)	0.7	1.7	4.2	-0.6	2.1	-0.4	-1.2	-1.6
Number of treatments/medications taken	1.3	2.3	5.0	1.4	-2.2	0.6	-0.1	2.1
Average weekly spirits intake	2.4	3.0	5.3	-2.0	2.2	-0.7	-0.7	-2.3
Sensitivity / hurt feelings	0.9	1.5	3.0	1.2	-1.7	0.8	-0.1	1.5
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	0.6	0.1	0.7	-0.4	-0.1
Hearing difficulty/problems: Yes	0.3	0.4	1.0	0.8	0.1	-1.0	-0.5	0.4
Relative age of first facial hair	0.1	0.2	0.4	-0.3	-0.4	0.1	-0.6	0.5
Other serious medical condition/disability diagnosed by doctor	2.5	3.3	4.8	1.9	-2.2	1.7	-0.9	2.1
Ever used hormone-replacement therapy (HRT)	1.3	1.7	5.9	-0.6	1.2	-2.4	0.3	-0.8
Ever had hysterectomy (womb removed)	0.7	0.8	2.0	1.4	0.3	-1.3	0.1	-0.4
Systolic blood pressure, automated reading	0.7	2.1	8.1	-1.5	0.0	-2.8	0.3	0.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.2	-0.7	-0.2	0.8	-1.1	0.1
Angina	0.3	0.4	1.2	-0.0	0.1	-1.1	1.0	-0.3
Medication for hormone replacement therapy	1.4	1.5	4.7	1.6	0.1	-2.2	-0.1	0.5
Vitamin and mineral supplements	0.5	0.6	1.7	-0.1	0.9	-1.3	0.4	-0.8
Supplements: Zinc	0.9	1.0	2.6	0.7	-0.9	0.6	-1.6	0.9
Medication: Co-codamol	4.7	5.5	10.8	2.6	-3.3	0.2	0.4	3.1
Medication: Metformin	0.6	0.8	1.9	-0.5	-0.3	1.4	-1.2	-0.3
Diabetes (father)	0.7	0.8	1.5	-1.1	-0.4	1.1	1.2	0.3
Diabetes (mother)	1.7	2.2	5.1	-1.3	0.4	1.9	2.3	-0.7
Severe depression (siblings)	1.3	1.4	5.4	2.3	-0.7	-0.3	-0.6	0.8
Pack years adult smoking proportion	2.1	3.3	4.5	1.9	-2.1	1.4	1.4	2.0
Impedance of leg (right)	0.2	0.9	1.6	-1.3	-0.2	1.2	1.3	-0.1
Leg fat-free mass (left)	0.3	1.6	4.8	1.0	-0.5	-1.3	-2.2	0.7
Trunk fat percentage	0.2	0.9	1.9	-1.4	0.2	-1.3	1.0	-0.2
Hand grip strength (right)	1.0	2.7	6.5	-0.7	2.5	-0.9	-1.0	-2.2
Townsend deprivation index at recruitment	0.3	0.4	1.2	1.1	-0.3	-0.1	-0.8	0.3
Current tobacco smoking	0.5	0.8	1.5	0.6	-0.9	1.2	0.5	1.1
Average weekly fortified wine intake	2.1	2.5	4.1	2.0	-1.9	1.2	0.3	1.8
Maternal smoking around birth	0.3	0.4	0.8	-0.9	0.9	-0.3	-0.2	-0.4
Fed-up feelings	0.4	0.7	3.4	-0.1	-0.1	-0.1	1.9	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	0.5	-0.3	-0.2	0.9	0.7
Relative age voice broke	0.2	0.3	0.9	-0.5	-0.1	0.0	0.9	-0.3
Taking other prescription medications	5.2	8.0	13.2	3.0	-3.6	-0.3	-2.2	3.6
Age when periods started (menarche)	0.7	1.8	4.9	0.1	-0.9	-1.5	-2.2	1.0
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	3.5	0.1	1.3	-1.6	-1.9	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	0.9	0.9	-0.8	-0.6	0.9	0.7
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	2.0	-0.2	0.3	-1.3	1.4	-0.1
Qualifications: CSEs or equivalent	0.4	0.5	1.0	-0.0	-1.0	-0.8	0.5	0.7
Serious illness, injury or assault to yourself	0.4	0.5	1.0	1.0	-0.5	0.7	-0.9	0.2
High blood pressure	0.1	0.4	0.6	0.6	-0.8	-0.0	-0.6	0.7
Hayfever, allergic rhinitis or eczema	2.5	5.3	11.5	1.1	-3.3	1.6	-0.3	3.4
Multivitamins +/- minerals	1.2	1.6	5.4	0.6	-0.8	2.3	-1.0	0.7
Stomach or abdominal pain in last month	0.1	0.1	0.1	-0.3	-0.1	-0.4	0.3	0.3
Supplements: Glucosamine	0.4	0.5	1.3	1.1	-0.6	0.5	0.5	0.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.5	0.7	-0.4	-0.7	0.1	0.6
Medication: Atenolol	0.6	0.8	1.5	1.0	-1.2	0.1	0.2	1.2
Medication: Levothyroxine sodium	1.9	3.3	3.7	1.7	-1.8	1.8	-1.9	1.8
Sitting height	0.5	3.6	6.0	2.0	-1.7	-0.7	-2.4	2.2
Chronic bronchitis/emphysema (father)	0.9	1.0	4.4	0.5	-0.4	-0.4	2.1	0.5
High blood pressure (mother)	3.2	4.5	19.3	-1.4	1.1	-4.4	0.0	-0.5
Body mass index (BMI)	0.2	0.7	1.0	-0.6	0.9	-0.9	0.6	-1.0
Impedance of leg (left)	0.2	0.9	2.7	-1.6	0.2	0.6	1.1	-0.4
Leg predicted mass (left)	0.3	1.6	5.0	0.9	-0.4	-1.2	-2.2	0.7
Trunk fat mass	0.1	0.5	1.7	-0.9	0.2	-1.3	0.2	-0.1
Waist circumference	0.1	0.4	0.9	-0.5	0.7	-0.9	0.1	-0.8
Number of incorrect matches in round	1.8	3.0	5.4	2.3	-1.9	1.2	1.3	1.7
Past tobacco smoking	0.9	1.7	3.0	-0.5	-1.7	1.6	-0.2	1.7
Alcohol usually taken with meals	0.8	1.2	2.8	1.7	-1.3	0.8	0.1	1.1
Nervous feelings	0.5	0.9	3.0	0.5	-0.1	-1.7	-1.1	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.1	0.7	-0.4	0.1	1.1	0.4
Hearing difficulty/problems with background noise	0.6	1.0	2.2	0.7	-1.1	0.9	-0.2	1.5
Hair/balding pattern: Pattern 2	0.9	1.1	2.1	-0.1	1.3	-0.2	-1.4	-1.4
Had menopause	0.3	0.4	1.3	0.1	0.7	-0.1	-1.1	-0.5
Had other major operations	1.2	1.4	3.2	0.9	-1.6	-0.9	0.1	1.8
Forced vital capacity (FVC)	1.1	4.4	9.0	1.4	-2.9	-0.5	-1.5	3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	4.2	2.1	-1.7	0.2	0.4	1.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.0	0.1	0.5	-1.0	-1.4	-0.2
Qualifications: None of the above	0.4	0.9	2.6	1.0	-0.0	-1.6	1.0	-0.2
Financial difficulties in last 2 years	0.7	0.9	1.4	1.0	-1.0	0.2	-1.2	1.1
Mouth/teeth dental problems	0.4	0.7	1.1	0.5	1.0	-0.3	1.0	-1.1
Heart attack	0.9	1.1	3.7	-0.1	-0.4	-1.1	-1.9	0.7
Allergy	2.2	5.1	10.6	-1.4	3.1	-1.5	-1.1	-3.2
Pain all over the body in last month	0.5	0.5	1.1	0.7	-0.6	-1.1	-0.7	0.2
Diabetes (self-reported)	0.8	1.2	4.9	-0.7	0.0	2.2	-0.4	-0.6
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	4.7	0.9	-2.1	0.9	0.1	2.2
Medication: Ramipril	0.2	0.3	0.8	-0.6	0.0	-0.9	-0.6	0.1
Medication: Simvastatin	0.9	1.3	5.3	0.2	0.2	-2.3	0.9	-0.2
Fluid intelligence score	1.0	2.1	3.6	1.3	-1.9	1.2	0.4	1.9
Illnesses of siblings	0.5	0.7	1.8	0.3	0.6	1.1	-1.4	-0.4
Neuroticism score	0.3	0.5	0.8	0.8	-0.7	-0.7	-0.9	0.5
Weight	0.1	0.7	1.8	0.2	-0.3	-1.3	-1.2	0.4
Impedance of arm (right)	0.4	2.0	4.6	-0.6	-2.1	0.4	0.6	2.1
Arm fat percentage (right)	0.2	0.9	1.8	-1.1	0.3	-1.3	1.1	-0.4
Trunk fat-free mass	0.4	2.0	7.2	1.3	-0.2	-0.9	-2.7	0.6
Hip circumference	0.1	0.4	0.5	0.2	-0.7	-0.6	-0.6	0.7
Time employed in main current job	2.1	2.4	5.3	1.1	-2.0	0.1	1.3	2.3
Alcohol intake versus 10 years previously	2.5	3.7	5.4	2.3	-2.2	1.1	1.3	2.2
Father’s age at death	1.2	1.6	2.4	1.0	-1.6	1.1	0.9	1.5
Worrier / anxious feelings	0.8	1.5	2.1	1.3	-1.2	-1.2	-1.4	1.0
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	8.2	1.0	-0.8	-0.7	-2.9	0.8
Falls in the last year	1.0	1.3	2.1	0.3	-1.1	1.4	-1.3	1.2
Hair/balding pattern: Pattern 3	0.4	0.6	1.1	1.0	-0.7	-0.2	0.5	1.1
Number of live births	0.2	0.2	0.4	-0.2	-0.7	0.3	0.3	0.7
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	4.8	0.2	-2.2	-0.4	-1.2	2.2
Pulse rate	1.4	2.4	6.8	-0.1	0.6	-2.6	-2.1	-0.3
Happiness	0.2	0.3	0.6	-0.5	0.8	0.0	0.6	-0.5
Noisy workplace	0.6	0.8	1.5	-0.5	1.0	-0.2	1.1	-1.2
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.3	-0.6	0.4	0.2	0.2	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.1	-0.3	-0.8	0.2	0.5	1.0
Mouth/teeth dental problems: Dentures	0.8	1.4	3.3	0.6	-1.5	-0.1	0.9	1.8
Asthma	2.7	5.4	12.2	3.5	-2.3	-0.1	1.7	2.5
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	3.3	0.2	-0.6	-1.8	-0.1	0.7
Medication: Cholesterol lowering	0.3	0.5	1.2	-0.4	-0.6	-1.1	-0.0	0.9
Depression (self-reported)	0.9	1.1	2.7	0.7	-0.7	1.2	-1.6	0.6
Medication: Lansoprazole	0.7	0.8	2.5	1.6	-0.9	-0.3	0.2	0.5
Prospective memory result	1.8	2.3	5.3	-1.3	1.7	0.2	-1.2	-2.3
Lung cancer (father)	0.9	1.0	2.0	-1.2	1.4	-0.3	0.3	-1.2
Illnesses of mother	1.4	1.7	5.8	0.9	-0.6	2.4	1.2	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	4.4	0.4	-2.0	-0.9	-0.8	2.1
Pulse wave Arterial Stiffness index	0.0	0.1	0.1	0.1	-0.3	-0.1	0.3	0.2
Impedance of arm (left)	0.4	1.7	3.2	-1.2	-1.8	0.8	0.3	1.7
Arm fat mass (right)	0.1	0.6	2.2	-0.6	0.3	-1.5	-0.0	-0.4
Trunk predicted mass	0.3	2.0	7.2	1.2	-0.2	-0.9	-2.7	0.5
Standing height	0.7	7.1	15.2	1.9	-2.5	-1.0	-3.9	3.1
Length of working week for main job	0.3	0.3	1.2	-0.4	0.2	-0.3	1.1	-0.3
Exposure to tobacco smoke at home	0.4	0.5	1.7	0.8	-0.1	0.1	1.3	0.1
Breastfed as a baby	0.7	0.9	1.9	-0.3	-1.0	-1.1	-0.3	1.4
Tense / ‘highly strung’	0.1	0.1	0.3	-0.6	-0.0	-0.1	-0.4	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	5.1	-0.2	0.1	-0.3	-2.3	0.2
Hair/balding pattern: Pattern 4	2.1	5.0	7.4	-2.4	2.7	-2.1	0.4	-2.7
Birth weight of first child	0.3	0.6	3.0	1.7	0.0	-0.2	0.4	-0.0
Peak expiratory flow (PEF)	2.5	5.9	13.7	0.7	-3.4	-1.7	1.0	3.7
Pulse wave reflection index	0.9	1.1	3.2	-0.9	-0.1	1.8	1.3	-0.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.7	-0.7	0.4	-0.8	-0.9	-0.4
Loud music exposure frequency	1.3	1.4	3.2	-1.3	1.8	-0.1	0.2	-1.5
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.9	-1.4	0.3	1.3	1.3	-0.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	-0.5	-0.8	0.6	-0.2	0.8
Blood clot in the leg (DVT)	0.1	0.2	0.5	0.2	-0.0	0.7	-0.6	0.1
Medication: Paracetamol	0.2	0.3	0.8	-0.7	0.2	-0.4	0.9	-0.3
Headache pain in last month	0.4	0.7	2.0	0.8	-0.6	-0.2	1.4	0.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	3.8	0.6	-0.2	2.0	0.2	0.0
Glaucoma (self-reported)	0.1	0.2	0.6	0.5	0.0	-0.2	-0.7	0.1
Gout (self-reported)	0.6	0.8	2.5	-0.7	0.8	0.6	-1.6	-0.5
Hypothyroidism/myxoedema (self-reported)	2.8	5.4	10.8	1.4	-1.7	2.9	-3.3	1.8
Medication: Amlodipine	3.1	4.3	8.3	1.9	-2.9	-1.2	-1.0	2.7
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.6	0.9	-1.6	0.6	1.2	1.4
Birth weight	0.2	0.3	0.9	0.3	0.1	0.7	-1.0	0.2
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.4	-0.1	0.3	0.7	0.5	-0.3
High blood pressure (siblings)	1.2	1.7	3.1	-1.8	0.9	-1.7	1.1	-0.9
Forced vital capacity (FVC), Best measure	1.0	3.5	7.7	1.2	-2.6	-1.2	-0.6	2.8
Body fat percentage	0.3	1.1	2.0	-1.4	0.4	-1.2	1.4	-0.5
Leg fat percentage (right)	0.4	1.4	3.9	-1.0	0.9	-0.5	2.0	-1.0
Arm fat-free mass (right)	0.3	1.7	6.4	1.0	0.4	-1.0	-2.5	-0.2
Exposure to tobacco smoke outside home	0.6	0.9	2.1	1.4	-0.6	0.9	-0.4	1.0
Comparative body size at age 10	0.2	0.6	2.1	-0.0	0.4	1.4	-0.8	-0.4
Number of full brothers	1.0	1.2	2.1	0.1	-1.0	-1.2	1.4	1.2
Worry too long after embarrassment	0.7	1.1	2.4	0.3	-0.9	1.2	-1.6	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	8.4	1.1	-0.5	0.8	-2.9	0.6
Wheeze or whistling in the chest in last year	1.5	2.6	4.4	2.1	-2.0	0.5	0.2	2.0
Number of children fathered	0.6	0.7	1.3	-1.1	-0.8	-0.4	1.1	0.4
Reason for reducing amount of alcohol drunk: Health precaution	3.2	3.7	11.4	3.4	-1.9	-1.2	0.1	1.5
Age at first live birth	0.1	0.2	0.6	-0.8	0.1	0.0	-0.5	0.3
Pulse wave peak to peak time	0.1	0.1	0.3	0.1	-0.0	0.3	-0.6	0.2
Health satisfaction	0.6	0.7	2.2	-0.4	0.8	-1.5	-0.3	-0.8
Shortness of breath walking on level ground	0.6	0.7	1.7	0.3	-0.6	-1.2	1.3	0.2
Qualifications: College or University degree	1.6	5.1	7.6	-2.4	2.8	0.2	-2.4	-2.6
Eye problems/disorders: None of the above	1.3	1.5	2.3	-1.2	1.3	0.2	1.3	-1.5
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.5	-1.2	0.4	0.0	0.1	-0.6
Emphysema/chronic bronchitis	0.7	0.7	1.3	0.4	-1.1	0.7	0.7	1.1
Medication for pain relief, constipation, heartburn	0.4	0.7	1.2	-0.5	1.0	0.6	-1.1	-0.8
Neck or shoulder pain in last month	1.4	2.0	8.5	0.5	-0.5	-2.9	-0.9	0.4
Medication: Blood pressure	1.0	1.7	5.1	-1.2	1.1	-2.3	0.1	-0.9
Angina (self-reported)	0.3	0.5	1.6	0.0	0.0	-1.3	0.7	-0.3
Migraine (self-reported)	0.8	1.0	1.5	1.2	-1.2	0.2	-0.9	1.1
Medication: Ibuprofen	0.6	0.8	2.1	0.0	-0.9	-1.4	0.4	0.9
Medication: Allopurinol	0.5	0.6	2.5	-0.5	0.3	-0.6	-1.6	0.3
Medication: Omeprazole	0.2	0.3	0.7	0.2	0.1	-0.8	0.6	-0.4
Medication: Seretide 50 evohaler	1.4	1.7	6.4	0.7	-0.8	-0.1	2.5	0.9
Mean time to correctly identify matches	0.0	0.1	0.2	0.1	-0.3	0.5	0.0	0.1
Heart disease (mother)	0.6	0.7	1.9	-0.2	-0.1	-1.2	-1.4	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	4.7	-2.0	1.8	0.5	0.1	-2.2
Whole body fat mass	0.1	0.5	1.6	-0.9	0.2	-1.3	0.5	-0.2
Leg fat mass (right)	0.2	0.7	1.7	-0.8	0.8	-1.3	0.4	-0.8
Arm predicted mass (right)	0.3	1.7	6.6	0.8	0.3	-1.0	-2.6	-0.1
Pulse rate, automated reading	1.9	6.1	26.7	-1.2	0.7	-5.2	-1.4	-0.1
Alcohol intake frequency.	0.7	1.7	3.2	1.7	-1.8	0.1	0.1	1.6
Comparative height size at age 10	0.4	2.0	2.9	1.4	-1.5	-0.6	-1.6	1.7
Number of full sisters	1.1	1.4	5.8	-0.7	-0.1	-0.7	2.4	-0.1
Suffer from ‘nerves’	0.0	0.1	0.1	0.0	-0.3	0.1	0.2	0.4
Overall health rating	1.1	2.4	5.5	1.6	-1.2	-2.3	-0.7	1.4
Chest pain or discomfort	0.2	0.3	0.8	0.2	-0.9	-0.6	0.2	0.4
Had major operations	5.2	6.1	10.1	2.8	-3.0	0.5	-1.8	3.2
Age at last live birth	0.3	0.5	1.4	-0.9	-0.0	0.5	-1.2	0.0
Family relationship satisfaction	0.1	0.1	0.5	0.7	0.2	-0.3	-0.3	-0.0
Leg pain on walking	1.2	1.5	3.9	1.0	-1.1	-0.3	2.0	1.2
Qualifications: NVQ or HND or HNC or equivalent	3.4	4.1	11.4	1.2	-1.6	1.4	3.4	1.8
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.0	0.8	-1.3	-0.4	0.7	1.4
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.1	-1.0	1.7	-0.4	0.5	-1.8
Medication: Aspirin	0.3	0.3	0.9	-1.0	0.2	-0.3	-0.6	-0.6
Supplements: Vitamin C	0.5	0.6	1.0	1.0	-0.7	0.0	0.9	0.8
Knee pain experienced in last month	0.4	0.7	1.9	0.2	-0.8	1.4	0.6	0.7
Hypertension (Self-reported)	0.2	0.4	0.8	0.9	-0.8	0.1	0.0	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	2.4	-0.2	0.0	-0.5	1.5	-0.1
Illnesses of father: Heart disease	0.2	0.2	0.9	-0.3	0.1	0.2	-0.9	-0.3
Illnesses of siblings: Diabetes	1.1	1.4	3.6	-1.7	0.1	0.5	1.9	-0.2
Smoking status: Previous	0.8	1.1	2.1	0.4	1.4	-1.1	0.7	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	4.3	0.6	-1.9	-0.4	-2.1	1.8
Whole body fat-free mass	0.3	2.0	7.0	1.1	-0.2	-1.2	-2.6	0.5
Leg fat-free mass (right)	0.4	2.1	6.3	1.0	-0.3	-1.7	-2.5	0.7
Arm fat percentage (left)	0.2	0.8	1.8	-1.3	0.4	-1.1	1.0	-0.5
Average weekly red wine intake	0.7	1.0	2.9	0.9	-0.5	1.7	-0.9	0.6
Handedness (chirality/laterality): Left-handed	2.5	3.0	5.4	0.7	-2.2	0.3	-2.0	2.3
Mood swings	0.4	0.7	1.2	1.1	-0.8	-0.4	-0.7	1.0
Loneliness, isolation	0.4	0.6	1.6	-0.4	0.7	1.2	-0.5	-0.7
Long-standing illness, disability or infirmity	4.2	6.4	11.1	2.5	-3.2	1.9	-1.0	3.3
Ever had bowel cancer screening	0.3	0.3	0.6	0.8	-0.5	0.7	0.4	0.3
Diabetes diagnosed by doctor	0.7	1.1	4.1	-1.0	-0.1	2.0	-0.3	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	3.9	1.7	-1.8	0.7	-1.1	2.0
Friendships satisfaction	0.7	0.8	2.7	-0.2	1.0	-0.1	-1.6	-0.7
Qualifications: nursing, teaching	0.5	0.7	1.4	-0.8	0.6	1.1	-1.2	-0.2
Commuting to job workplace: Walk	0.4	0.4	1.1	-0.7	0.7	-0.4	0.1	-1.0
Eye problems/disorders: Cataract	0.6	0.7	2.5	0.9	-0.2	-1.6	-0.2	0.5
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	4.4	-0.7	0.4	1.3	-2.1	-0.3
Medication for cholesterol	1.6	2.4	5.2	-2.3	1.6	1.4	-0.6	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	5.1	2.3	-1.6	0.8	1.2	1.4
Back pain experienced in last month	0.4	0.6	1.3	0.1	-1.0	0.3	0.6	1.1
Mineral and other dietary supplements	1.3	1.8	3.6	-1.4	1.9	-0.6	0.8	-1.5
Breast cancer (self-reported)	1.5	1.7	3.9	1.6	-0.9	-2.0	0.4	1.2
Asthma (self-reported)	2.2	4.5	10.0	3.2	-2.2	0.0	1.3	2.4
Osteoporosis (self-reported)	2.2	2.7	6.8	2.6	-1.7	0.3	-1.1	1.6
Osteoarthritis (self-reported)	1.1	1.5	2.2	1.5	-1.1	-1.4	0.8	1.2
Medication: Aspirin	0.1	0.1	0.2	-0.5	0.0	-0.0	-0.4	-0.4
Medication: Gliclazide	0.7	0.8	2.2	-0.8	0.9	0.6	0.1	-1.5
Illnesses of father: None of the above (group 1)	1.1	1.3	3.5	1.9	-0.9	0.9	-0.6	1.1
Smoking status: Current	0.5	0.8	2.1	0.8	-0.6	1.4	0.6	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	0.9	0.8	-1.0	-0.8	0.5	0.9
Whole body water mass	0.3	2.0	7.2	1.2	-0.2	-1.1	-2.7	0.4
Leg predicted mass (right)	0.4	2.0	6.0	0.9	-0.3	-1.6	-2.5	0.6
Arm fat mass (left)	0.1	0.6	2.1	-0.8	0.4	-1.4	-0.1	-0.4
Number of self-reported non-cancer illnesses	5.0	8.6	13.5	3.7	-3.5	-0.3	-1.8	3.7
Average weekly champagne plus white wine intake	0.8	1.1	3.9	1.1	0.2	2.0	-0.4	-0.3
Miserableness	1.3	2.2	5.7	2.4	-1.5	-0.2	0.8	1.6
Guilty feelings	0.4	0.6	1.4	-0.3	1.1	0.0	-0.6	-1.2
Wears glasses or contact lenses	0.8	0.9	3.0	-0.3	-0.2	-0.9	-1.7	0.5
Ever taken oral contraceptive pill	2.1	2.4	4.5	1.5	-2.0	1.1	-0.3	2.1
Hearing aid user	0.3	0.4	1.1	0.2	-0.8	-0.5	-0.0	1.0
Mother’s age at death	0.8	1.0	4.7	-0.5	0.2	2.2	0.2	-0.3
Financial situation satisfaction	0.2	0.3	0.6	-0.1	0.8	-0.4	-0.4	-0.5
Tinnitus: Yes, now most or all of the time	2.4	2.9	5.2	2.0	-2.1	0.8	0.1	2.3
Commuting to job workplace: Public transport	1.8	2.1	3.8	-1.6	2.0	0.3	-1.1	-1.7
Eye problems/disorders: Glaucoma	0.2	0.2	0.8	0.4	0.0	-0.4	-0.9	0.2
Medication: Blood pressure	1.4	2.6	5.7	1.8	-2.4	0.8	-0.2	1.8
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	0.3	0.0	-0.2	-0.0	0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.9	-0.0	-1.0	0.7	-0.3	0.4
High cholesterol (Self-reported)	1.1	1.9	6.6	-0.8	1.2	-2.6	-0.3	-0.9
Medication: Bendroflumethiazide	1.2	1.8	5.3	0.7	-1.2	-0.7	-2.3	1.2
Medication: Paracetamol	0.2	0.3	1.1	-0.4	-0.1	-0.3	1.1	-0.1
Medication: Lisinopril	0.9	1.2	2.3	-1.1	1.4	-0.6	0.0	-1.5
Medication: Atorvastatin	0.9	1.2	4.2	-1.3	0.1	-2.0	-0.1	-0.1
Illnesses of father: High blood pressure	2.6	3.2	6.2	-2.5	2.1	-0.5	0.2	-2.3
Alcohol drinker status: Never	1.1	1.3	2.3	0.8	-1.3	0.1	1.3	1.5
Ever smoked	0.9	1.5	3.2	-0.0	1.8	-1.4	-0.3	-1.5
Basal metabolic rate	0.3	1.7	6.1	0.9	-0.1	-1.3	-2.5	0.4
Leg fat percentage (left)	0.5	1.7	3.7	-1.1	1.1	-0.9	1.9	-1.2
Arm fat-free mass (left)	0.3	1.7	4.7	1.3	0.1	-1.4	-2.2	0.2
Number of operations (self-reported)	0.5	0.7	1.2	1.1	-0.9	-0.4	-0.2	1.1
Average weekly beer plus cider intake	0.4	0.6	2.8	-0.1	0.4	-0.1	1.7	-0.4
Irritability	0.4	0.7	2.6	1.6	-0.2	-0.9	-0.1	0.1
Risk taking	1.2	1.7	2.9	1.5	-1.4	1.2	-0.5	1.7
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.9	-2.0	0.8	0.4	1.5	-0.7
Fractured/broken bones in last 5 years	0.9	1.2	4.8	0.4	0.6	-0.7	-2.2	-0.5
Age started oral contraceptive pill	0.9	1.1	1.8	0.9	-1.3	0.5	1.0	1.3
Diastolic blood pressure, automated reading	0.5	1.5	3.7	-1.5	-0.8	-1.9	0.0	0.9
Ever depressed for a whole week	1.4	1.7	5.1	-0.5	1.0	-1.2	-2.3	-0.8
Unable to work because of sickness or disability	1.5	2.0	5.1	2.3	-1.5	-0.1	-0.9	1.3
Commuting to job workplace: Cycle	1.4	1.6	6.3	-0.4	-0.2	-1.2	-2.5	0.5
Myopia	1.4	2.0	5.2	2.3	-1.2	-0.7	-1.1	1.4
Vascular/heart problems diagnosed by doctor	0.2	0.4	1.0	-0.4	1.0	0.4	0.2	-0.9
Cholesterol lowering medication	1.5	2.3	8.4	-0.0	1.0	-2.9	0.8	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.6	1.2	-0.2	-0.6	1.9	-0.2
Pain experienced in last month	1.1	1.8	4.4	-0.6	2.0	0.5	-0.0	-2.1
Supplements: Calcium	0.5	0.5	1.3	1.2	-0.1	0.4	-1.0	-0.2
Basal cell carcinoma (self-reported)	0.8	1.0	2.0	-1.4	1.2	-0.2	-0.5	-1.1
Heart attack/myocardial infarction (self-reported)	0.9	1.2	4.5	-0.1	-0.5	-0.8	-2.1	0.7
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.3	0.1	-0.1	0.5	-0.6	0.2
Heart disease (siblings)	0.7	0.9	1.8	1.3	-0.7	1.3	-0.5	0.6
Alcohol drinker status: Previous	1.8	2.0	5.6	2.4	-0.6	-0.2	-1.9	0.5
Pack years of smoking	2.0	3.0	4.1	1.7	-2.0	1.3	1.5	2.0
Impedance of whole body	0.2	1.2	1.9	-1.4	-1.1	0.9	1.1	0.9
Leg fat mass (left)	0.2	1.0	2.3	-0.8	0.9	-1.5	0.4	-0.9
Arm predicted mass (left)	0.4	1.9	6.2	1.4	0.0	-1.2	-2.5	0.2