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chr2:231,564,626-234,168,951

Best TWAS P=7.45e-22 · Best GWAS P=3.24e-23 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Aorta	B3GNT7	0.30	0.20	lasso	6	0.16	3.2e-09	-9.9	9.6	9.3e-22	-0.99	0.00	1.00	FALSE
2	GTEx	Cells Transformed fibroblasts	EIF4E2	0.16	0.06	lasso	3	0.05	2.2e-04	-5.6	-5.7	1.5e-08	0.04	0.01	0.98	FALSE
3	GTEx	Colon Transverse	EIF4E2	0.27	0.17	enet	19	0.18	7.7e-09	-5.5	5.4	6.4e-08	-0.06	0.01	0.99	FALSE
4	GTEx	Colon Transverse	AC073254.1	0.22	0.13	lasso	4	0.15	9.3e-08	-5.4	5.6	2.5e-08	-0.04	0.01	0.99	FALSE
5	GTEx	Heart Left Ventricle	EIF4E2	0.41	0.23	lasso	3	0.27	1.6e-14	-5.6	5.4	5.3e-08	-0.05	0.01	0.99	FALSE
6	GTEx	Prostate	B3GNT7	0.34	0.15	lasso	3	0.08	4.4e-03	-9.6	9.6	7.5e-22	-0.99	0.01	0.98	TRUE
7	GTEx	Testis	B3GNT7	0.31	0.06	lasso	7	0.09	5.8e-05	-9.6	8.2	2.5e-16	-0.81	0.01	0.98	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	EIF4E2	0.12	0.07	lasso	6	0.06	9.4e-08	-5.4	-5.4	6.7e-08	0.04	0.01	0.98	FALSE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	EIF4E2	0.03	0.03	enet	8	0.04	4.4e-08	4.1	-5.9	3.6e-09	0.07	0.22	0.77	FALSE
10	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	B3GNT7	0.03	0.01	blup	36	0.02	4.0e-03	-8.8	8.5	1.8e-17	-0.91	0.01	0.95	FALSE
11	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EFHD1	0.11	0.01	blup	70	0.03	1.0e-02	3.3	5.5	5.0e-08	0.00	0.05	0.04	TRUE
12	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EIF4E2	0.12	0.12	lasso	10	0.11	4.8e-07	-5.6	5.3	1.2e-07	-0.04	0.01	0.99	FALSE
13	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TIGD1	0.09	0.07	blup	57	0.07	5.6e-05	-5.5	5.4	5.4e-08	-0.07	0.01	0.98	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	B3GNT7	0.03	0.03	blup	33	0.02	8.8e-04	4.9	-5.7	1.5e-08	0.57	0.17	0.32	FALSE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	EFHD1	0.05	0.01	blup	70	0.01	1.7e-02	-3.1	-5.9	3.3e-09	-0.03	0.04	0.34	TRUE
16	The Cancer Genome Atlas	Brain Lower Grade Glioma	EIF4E2	0.03	0.01	blup	60	0.02	2.7e-03	3.1	-5.6	1.7e-08	0.05	0.09	0.14	FALSE
17	The Cancer Genome Atlas	Prostate Adenocarcinoma	B3GNT7	0.05	0.06	blup	36	0.05	2.6e-06	-9.6	9.0	1.9e-19	-0.95	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Thyroid Carcinoma	EIF4E2	0.03	0.01	blup	63	0.02	4.7e-03	4.1	-5.2	2.0e-07	0.06	0.08	0.11	FALSE