Best TWAS P=6.53e-11 · Best GWAS P=3.87e-10 conditioned to 0.000154
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | EAF1-AS1 | 0.06 | 0.04 | enet | 13 | 0.03 | 4.4e-03 | 6.1 | 6.5 | 6.5e-11 | -0.44 | 0.02 | 0.93 | TRUE |
| 2 | GTEx | Skin Sun Exposed Lower leg | COLQ | 0.07 | 0.00 | lasso | 4 | 0.00 | 2.3e-01 | 6.0 | -5.9 | 3.0e-09 | 0.35 | 0.03 | 0.90 | FALSE |
| 3 | GTEx | Testis | EAF1-AS1 | 0.10 | 0.06 | lasso | 4 | 0.05 | 3.6e-03 | 6.0 | 6.0 | 2.6e-09 | -0.53 | 0.03 | 0.93 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | COLQ | 0.05 | 0.03 | enet | 10 | 0.04 | 5.7e-06 | 5.2 | -5.3 | 1.1e-07 | 0.44 | 0.07 | 0.93 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | METTL6 | 0.04 | 0.00 | blup | 65 | 0.02 | 1.0e-03 | 5.5 | 5.3 | 9.2e-08 | -0.27 | 0.03 | 0.83 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EAF1 | 0.05 | 0.05 | lasso | 5 | 0.04 | 4.3e-05 | 5.4 | 5.4 | 5.3e-08 | -0.51 | 0.16 | 0.84 | FALSE |
| 7 | The Cancer Genome Atlas | Soft Tissue Sarcoma | HACL1 | 0.10 | 0.02 | blup | 84 | 0.05 | 5.1e-04 | 5.5 | -6.3 | 2.2e-10 | 0.33 | 0.02 | 0.57 | FALSE |