TWAS hub - HYAL4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0179	0.0099	0.00120	0.013	0.012	0.011	NA	0.012	8.5e-04	0.00150	0.00180	NA	1.5e-03
2	TCGA	Colon Adenocarcinoma	0.1360	0.0650	0.00016	0.055	0.061	0.052	NA	0.038	3.8e-04	0.00019	0.00056	NA	3.1e-03
3	TCGA	Lung Adenocarcinoma	0.0458	0.0249	0.00320	0.034	0.022	0.029	NA	0.034	6.0e-05	0.00130	0.00020	NA	6.6e-05
4	TCGA	Stomach Adenocarcinoma	0.0750	0.0400	0.00080	0.056	0.047	0.039	NA	0.053	6.8e-05	0.00025	0.00084	NA	1.1e-04
5	TCGA	Testicular Germ Cell Tumors	0.1410	0.0780	0.00210	0.084	0.021	0.002	NA	0.027	6.7e-04	0.06200	0.26000	NA	3.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Blood Platelet Count	14.1	163.2	488.4	9.3	11.7	22.1	10.0	2.3
Illness, injury, bereavement, stress in last 2 years	7.7	9.4	12.8	-3.6	-3.1	-2.6	-3.5	2.4
Serious illness, injury or assault to yourself	6.6	8.0	12.8	3.6	3.0	1.7	3.4	-2.0
HbA1C	4.3	4.8	15.2	-1.8	-1.9	-3.9	-1.0	0.9
Family relationship satisfaction	3.3	4.1	6.9	2.2	1.9	2.6	1.8	-1.4
Medication for hormone replacement therapy	3.1	3.5	10.1	1.9	0.9	1.0	1.3	-3.2
Tinnitus: Yes, but not now, but have in the past	3.1	3.3	5.6	-2.1	-2.1	-1.0	-2.4	1.0
Pulse rate, automated reading	3.0	9.6	42.0	-1.7	0.6	0.6	-1.5	6.5
Number of treatments/medications taken	2.9	5.3	9.6	3.1	2.0	0.9	2.7	-2.2
Medication: Cholesterol lowering	2.9	4.5	8.0	2.1	2.7	0.9	2.8	-1.4
Medication: Aspirin	2.9	3.8	5.2	2.2	1.9	1.4	1.9	-2.3
High blood pressure (mother)	2.8	4.0	10.9	1.4	0.4	2.2	1.3	-3.3
Had major operations	2.7	3.2	5.1	2.1	1.4	1.0	2.3	-1.9
Medication: Aspirin	2.5	3.3	4.5	2.1	1.8	1.3	1.8	-1.9
Medication for cholesterol, blood pressure or diabetes	2.4	4.0	6.4	-2.1	-1.6	-0.8	-2.5	2.5
Medication: Omeprazole	2.3	2.7	4.9	1.6	2.2	1.1	2.1	-0.6
Length of working week for main job	2.2	2.4	6.5	-1.4	-2.6	-1.3	-1.4	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.8	3.8	-1.8	-1.8	-0.5	-1.9	1.9
Average weekly champagne plus white wine intake	2.1	2.9	5.9	-2.0	-1.9	0.4	-2.4	1.1
Medication: Lisinopril	2.1	2.7	8.3	1.7	0.3	0.2	1.5	-2.9
Crohns Disease (2012)	1.9	3.1	4.6	1.8	2.1	2.0	1.9	-0.1
Falls in the last year	1.9	2.6	8.8	1.5	1.1	3.0	0.6	-0.7
Medication: Atenolol	1.8	2.2	3.4	1.9	1.4	0.8	1.8	-1.5
Tense / ‘highly strung’	1.8	2.9	4.2	-1.6	-2.0	-1.5	-2.0	1.2
Cardiovascular Disease	1.7	5.6	10.7	2.5	1.5	1.2	2.7	-3.3
Ever used hormone-replacement therapy (HRT)	1.7	2.1	6.9	1.0	0.8	2.6	1.0	-1.1
Had other major operations	1.7	2.1	9.9	0.1	0.4	3.1	0.0	0.7
Risk taking	1.7	2.5	3.8	1.7	1.9	1.3	1.9	-0.7
Body Mass Index (BMI) (2010)	1.6	2.2	4.2	-1.6	-2.0	-0.6	-2.0	0.1
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	2.9	-1.6	-1.0	-1.7	-1.4	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	2.2	1.3	1.4	1.2	1.4	-1.5
Exposure to tobacco smoke outside home	1.6	2.1	6.1	-1.0	-1.6	-2.5	-0.9	-0.4
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	3.7	1.4	1.8	0.7	1.9	-0.3
Friendships satisfaction	1.5	1.9	3.9	1.2	1.1	2.0	1.5	-0.7
Number of self-reported non-cancer illnesses	1.5	2.6	4.0	1.9	1.6	0.4	2.0	-1.7
Alcohol drinker status: Previous	1.5	1.7	2.6	1.1	1.3	-0.9	1.5	-1.6
Prostate Cancer	1.4	2.0	3.3	1.8	1.5	0.6	1.8	-1.0
Qualifications: College or University degree	1.4	4.5	8.7	-2.4	-1.9	-1.4	-3.0	1.7
Knee pain experienced in last month	1.4	2.2	3.8	1.6	1.0	1.6	1.2	-2.0
High cholesterol (Self-reported)	1.4	2.5	6.4	1.5	1.9	-0.2	2.5	-0.1
Age at First Birth	1.3	1.9	3.7	-1.0	-1.5	0.9	-1.4	1.9
Type 2 Diabetes (T2D) (2018)	1.3	2.5	5.9	1.0	1.2	2.4	1.3	-1.5
Mouth/teeth dental problems: Loose teeth	1.3	1.5	2.0	-1.4	-1.4	-1.2	-1.3	-0.6
Medication: Blood pressure	1.3	2.4	7.3	1.4	0.5	0.4	1.4	-2.7
Age at last live birth	1.3	1.9	3.0	-1.5	-1.6	-1.2	-1.7	0.2
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.9	1.2	1.1	0.9	1.3	-1.7
Number of operations (self-reported)	1.3	1.9	2.7	1.5	0.7	1.6	1.2	-1.6
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.7	-1.3	-1.2	0.7	-1.3	1.6
Tinnitus: Yes, now most or all of the time	1.2	1.4	1.9	1.2	0.5	1.4	1.3	-1.4
Alzheimer’s Disease (in mother)	1.1	1.3	2.2	-1.4	-1.5	-1.1	-1.0	-0.1
Ulcerative Colitis (UC)	1.1	2.2	3.8	-1.9	-1.2	-1.9	-1.1	0.9
Bipolar Disorder (2011)	1.1	1.0	2.8	0.9	0.9	0.8	0.4	-1.7
Coronary Artery Disease (CAD)	1.1	1.4	3.6	0.9	1.9	0.2	1.5	-0.5
Schizophrenia (2014)	1.1	2.4	7.9	-0.5	-1.0	-2.8	-0.7	-1.5
Hearing difficulty/problems with background noise	1.1	1.8	4.2	-0.9	-1.9	-0.8	-2.1	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	2.4	-1.4	-1.2	-0.7	-1.6	1.5
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.7	-1.0	-1.6	-0.3	-1.3	-1.1
Migraine (self-reported)	1.1	1.3	2.9	0.7	1.4	1.7	1.0	-0.4
Loneliness, isolation	1.1	1.5	2.5	1.2	1.2	1.6	1.1	-0.7
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.0	-0.9	-0.8	-1.5	-0.6	1.7
Commuting to job workplace: Cycle	1.1	1.4	2.6	1.5	1.6	-0.2	1.4	0.2
Blood Red Count	1.0	9.4	11.2	3.4	2.3	3.1	3.3	-3.2
Qualifications: CSEs or equivalent	1.0	1.4	2.8	1.1	1.0	0.1	1.7	-1.3
Illnesses of mother	1.0	1.3	3.5	0.4	1.5	-0.5	0.3	1.9
Heart disease (mother)	1.0	1.2	2.4	-0.1	-1.4	1.2	-0.5	-1.5
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.2	1.1	1.1	0.3	1.5	-0.9
Alzheimer’s Disease (including proxy)	0.9	1.2	2.6	-1.4	-1.6	-1.0	-0.8	0.1
Fed-up feelings	0.9	1.7	2.8	1.5	1.3	0.6	1.7	-1.1
Supplements: Glucosamine	0.9	1.2	5.3	-0.6	0.2	-0.3	-0.5	2.3
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.5	-1.3	-1.6	-0.0	-1.4	0.3
Time employed in main current job	0.9	1.1	3.6	-0.9	-0.9	-0.3	-0.4	1.9
Pulse rate	0.9	1.5	6.1	0.1	1.2	0.2	0.2	2.5
Happiness	0.9	1.1	3.1	0.8	0.4	0.4	1.1	-1.8
Qualifications: A levels/AS levels or equivalent	0.9	2.1	4.3	-1.7	-1.4	-0.9	-2.1	0.6
Pulse wave Arterial Stiffness index	0.9	1.1	2.0	1.3	1.4	0.8	1.1	0.2
Hair/balding pattern: Pattern 4	0.9	2.2	4.0	-0.9	-2.0	-1.8	-1.3	1.0
Number of full brothers	0.9	1.1	1.9	1.2	0.9	-1.0	0.9	-1.4
Age at first live birth	0.9	1.6	2.3	-1.4	-1.5	-0.9	-1.5	0.9
Health satisfaction	0.9	1.1	1.9	-1.1	-1.4	-1.3	-0.7	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.2	-0.6	-1.3	0.3	-0.8	-1.5
Medication: Gliclazide	0.9	1.0	4.3	0.6	0.4	0.5	0.4	-2.1
Medication: Bendroflumethiazide	0.9	1.4	3.0	1.4	0.6	0.4	1.3	-1.7
Ulcerative Colitis	0.8	1.2	3.1	-1.2	-0.9	-1.8	-0.8	0.2
Taking other prescription medications	0.8	1.3	1.8	1.2	1.3	1.3	1.2	-0.0
Birth weight of first child	0.8	1.4	4.5	-0.5	0.5	2.1	-0.3	1.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.3	-1.1	-1.1	-0.9	-1.5	0.6
Birth weight	0.8	1.7	3.8	-1.5	-1.6	0.0	-1.9	-0.1
Pulse wave peak to peak time	0.8	0.9	1.7	-1.2	-1.3	-0.7	-1.0	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.9	0.8	1.1	1.4	1.0	-0.1
Mother’s age at death	0.8	1.0	3.5	0.4	0.5	0.9	0.5	1.9
Financial situation satisfaction	0.8	1.0	1.4	1.0	1.2	1.1	1.0	0.7
Average weekly beer plus cider intake	0.8	1.2	1.8	1.3	0.3	1.2	0.9	-1.4
Schizophrenia (2018)	0.7	1.5	4.6	-0.7	-0.8	-2.2	-0.6	-1.2
Verbal and Numeric Reasoning (VNR)	0.7	1.6	6.7	-0.7	0.6	-0.3	-0.4	2.6
Breast Cancer	0.7	1.7	2.9	1.7	1.1	1.3	1.4	-0.8
Blood White Count	0.7	5.4	9.5	-2.3	-1.8	-2.2	-2.1	3.1
Ever had hysterectomy (womb removed)	0.7	0.8	1.4	0.9	0.8	1.2	0.6	-0.9
Relative age voice broke	0.7	1.1	2.7	1.1	0.8	0.9	0.5	-1.6
Impedance of arm (right)	0.7	3.3	9.6	0.7	1.9	1.1	1.2	3.1
Number of live births	0.7	1.0	2.9	0.7	0.9	1.7	0.9	-0.1
Impedance of arm (left)	0.7	3.2	10.8	0.4	1.7	1.3	0.9	3.3
Glaucoma (self-reported)	0.7	0.8	1.8	-0.9	-1.3	-0.3	-1.1	0.2
Medication for pain relief, constipation, heartburn	0.7	1.2	2.2	-1.1	-1.5	-1.1	-1.1	-0.1
Medication: Ibuprofen	0.7	0.8	1.7	-0.8	-1.3	-0.3	-1.3	0.3
Mean time to correctly identify matches	0.7	1.3	4.9	0.3	1.3	-0.2	0.3	2.2
Alcohol intake frequency.	0.7	1.6	2.7	1.4	1.0	0.1	1.5	-1.6
Hypertension (Self-reported)	0.7	1.9	2.9	1.7	1.1	0.8	1.4	-1.6
Illnesses of father: Heart disease	0.7	1.0	2.1	-1.2	-1.4	-0.3	-1.2	-0.1
Ever taken oral contraceptive pill	0.7	0.8	3.0	0.9	0.2	0.5	0.4	-1.7
Pain experienced in last month	0.7	1.2	2.2	-1.4	-0.9	1.0	-1.5	0.4
Worry (Nagel 2018)	0.6	1.3	2.4	-0.9	-0.9	-0.8	-1.6	1.4
Alzheimer’s Disease (in father)	0.6	0.7	1.1	-1.1	-1.0	-0.6	-0.7	0.3
LDL Cholesterol	0.6	1.0	2.3	-1.2	-0.7	-1.5	-0.4	0.8
Systolic Blood Pressure	0.6	3.1	13.5	0.8	0.6	-0.6	0.8	-3.7
Relative age of first facial hair	0.6	1.3	2.7	1.4	1.1	-0.2	0.9	-1.6
Vitamin and mineral supplements	0.6	0.8	2.5	0.6	1.0	-0.3	1.6	0.1
Supplements: Zinc	0.6	0.7	1.9	1.4	0.7	-0.2	0.9	-0.5
Diabetes (mother)	0.6	0.8	1.4	1.0	0.8	0.3	1.2	-0.9
Severe depression (siblings)	0.6	0.7	1.5	-0.2	-0.9	0.5	-1.2	-0.9
Average weekly fortified wine intake	0.6	0.8	1.3	1.1	1.1	0.2	0.9	0.7
High blood pressure	0.6	1.8	2.9	1.6	1.0	0.7	1.4	-1.7
Financial difficulties in last 2 years	0.6	0.8	1.4	1.1	1.2	0.7	0.7	-0.4
Mouth/teeth dental problems	0.6	0.9	2.5	0.7	1.0	-0.6	0.6	-1.6
Father’s age at death	0.6	0.8	1.4	0.6	1.1	0.7	1.2	0.6
Hair/balding pattern: Pattern 3	0.6	0.8	2.9	0.4	0.2	1.7	0.0	-1.0
Prospective memory result	0.6	0.7	1.2	1.0	0.2	-0.2	1.1	-1.1
Loud music exposure frequency	0.6	0.7	2.0	-0.8	-0.0	0.6	-0.6	1.4
Medication: Paracetamol	0.6	0.9	3.7	-0.3	0.1	-0.8	-0.4	1.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.6	0.8	1.3	1.2	0.6	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.6	-0.7	-0.0	-1.6	-0.2	0.7
Angina (self-reported)	0.6	0.8	3.0	-0.3	-0.4	-1.7	-0.6	-0.5
Average weekly red wine intake	0.6	0.9	3.4	-0.3	1.0	0.2	-0.2	1.8
Diabetes diagnosed by doctor	0.6	1.0	3.2	0.5	0.7	1.8	0.4	-0.9
Medication for cholesterol	0.6	0.9	2.7	-1.1	-0.2	0.0	-0.8	1.6
Back pain experienced in last month	0.6	0.9	4.3	-0.0	-0.5	-2.1	-0.0	-0.2
Osteoarthritis (self-reported)	0.6	0.8	3.1	0.5	0.3	1.8	0.3	0.7
Illnesses of father: None of the above (group 1)	0.6	0.7	1.2	1.1	0.9	-0.8	0.6	0.7
Commuting to job workplace: Public transport	0.6	0.7	2.0	-0.9	-0.1	-0.3	-0.9	1.4
Eye problems/disorders: Glaucoma	0.6	0.8	1.8	-0.9	-1.3	-0.4	-1.0	-0.4
Vascular/heart problems diagnosed by doctor	0.6	1.6	2.7	-1.4	-1.1	-0.4	-1.5	1.6
Bipolar Disorder or Schizophrenia	0.5	1.2	3.0	-0.1	-0.4	-1.6	-0.3	-1.7
Reaction Time	0.5	1.0	2.5	1.0	1.6	0.0	0.9	1.0
Fasting Glucose	0.5	0.6	2.2	0.6	0.4	0.2	0.5	-1.5
Triglycerides	0.5	0.8	1.8	0.9	0.5	0.9	0.5	-1.4
Respiratory disease	0.5	1.0	2.2	1.1	1.5	-0.1	1.2	-0.5
Angina	0.5	0.7	2.9	-0.2	-0.3	-1.7	-0.4	-0.5
Maternal smoking around birth	0.5	0.7	2.0	-0.4	-1.1	-0.2	-0.1	-1.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	0.8	0.8	0.7	1.1	-0.5
Chronic bronchitis/emphysema (father)	0.5	0.6	1.8	-0.5	-0.1	1.4	-0.1	1.0
Pain all over the body in last month	0.5	0.6	1.2	0.6	0.1	1.1	-0.0	-1.1
Medication: Simvastatin	0.5	0.7	1.3	0.7	1.1	0.6	1.1	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.4	-0.0	-1.2	0.2	-0.6	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	4.2	-1.2	-2.0	-0.4	-1.4	0.4
Exposure to tobacco smoke at home	0.5	0.5	1.3	-0.7	-0.9	-1.1	-0.4	-0.2
Leg fat percentage (right)	0.5	1.7	2.9	1.5	1.5	1.1	1.7	-0.1
Shortness of breath walking on level ground	0.5	0.6	1.5	-0.5	-1.0	0.3	-0.4	-1.2
Neck or shoulder pain in last month	0.5	0.7	1.0	0.7	0.9	0.5	1.0	1.0
Medication: Seretide 50 evohaler	0.5	0.6	1.4	1.2	0.5	-0.4	0.9	-0.6
Smoking status: Previous	0.5	0.7	1.8	-0.6	0.4	1.1	-0.1	1.3
Breast cancer (self-reported)	0.5	0.6	1.3	0.7	0.7	1.2	0.7	-0.3
Medication: Blood pressure	0.5	0.9	1.7	1.1	0.7	0.1	1.3	-1.1
Fractured/broken bones in last 5 years	0.5	0.6	1.6	0.5	-0.4	1.3	0.3	-1.0
Myopia	0.5	0.8	2.8	0.5	0.6	1.7	0.2	0.7
Heart disease (siblings)	0.5	0.6	0.9	-0.9	-0.6	-0.4	-0.8	1.0
Depressed Affect (Nagel 2018)	0.4	0.8	1.2	0.9	0.7	1.1	0.9	-0.9
Intelligence (Savage-Jansen 2018)	0.4	1.3	5.0	-0.6	0.8	-0.6	-0.2	2.2
Major Depression (MDD)	0.4	0.4	1.2	-0.1	0.9	0.2	0.3	1.1
Mean Putamen Volume	0.4	0.4	1.4	0.5	0.6	-0.3	0.4	-1.2
Lupus	0.4	0.6	0.9	0.8	0.6	0.9	0.9	0.6
Neuroticism (2016)	0.4	0.5	1.5	-1.2	-0.6	-0.4	-0.7	0.2
Smoking Status	0.4	0.8	1.8	-1.0	-0.9	-0.0	-1.3	0.8
Lung FEV1/FVC ratio	0.4	1.8	4.0	-0.5	-2.0	-1.0	-1.2	-1.6
Chronotype (morning person)	0.4	1.0	2.9	0.7	1.7	0.6	0.8	-0.8
Medication: Co-codamol	0.4	0.4	0.9	0.2	0.3	-0.9	0.8	0.7
Pack years adult smoking proportion	0.4	0.5	1.7	0.1	-0.5	-1.3	-0.3	-0.9
Trunk fat percentage	0.4	1.5	1.9	1.0	1.2	1.4	1.4	1.1
Townsend deprivation index at recruitment	0.4	0.6	2.2	-0.2	-0.3	-1.5	-0.8	0.2
Current tobacco smoking	0.4	0.7	1.5	-0.5	-1.2	-0.7	-1.0	-0.4
Multivitamins +/- minerals	0.4	0.5	1.3	-0.5	-0.6	0.2	-1.1	-0.7
Stomach or abdominal pain in last month	0.4	0.5	1.9	0.1	-0.0	-1.4	-0.3	0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.5	0.2	0.3	-0.5	0.5	1.2
Alcohol usually taken with meals	0.4	0.7	2.7	-0.5	0.2	0.2	-0.5	1.6
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	-0.0	0.4	-0.6	1.0	-0.9
Arm fat percentage (right)	0.4	1.5	2.4	1.3	1.4	1.0	1.5	0.6
Alcohol intake versus 10 years previously	0.4	0.6	1.2	-0.4	-1.0	-1.1	-0.6	-0.7
Worrier / anxious feelings	0.4	0.8	1.8	-0.5	-0.6	-0.5	-1.1	1.3
Asthma	0.4	0.8	1.9	0.7	1.4	0.5	0.9	-0.7
Breastfed as a baby	0.4	0.4	1.4	-0.2	0.9	0.3	0.0	1.2
Pulse wave reflection index	0.4	0.5	0.9	0.7	0.5	0.5	0.7	-1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.1	-0.8	-0.3	-0.7	-0.9	1.4
Body fat percentage	0.4	1.5	2.1	1.1	1.4	1.2	1.5	0.8
Emphysema/chronic bronchitis	0.4	0.4	1.3	0.4	0.7	1.2	0.0	-0.4
Leg pain on walking	0.4	0.5	1.0	-0.7	-1.0	-0.9	-0.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	1.0	0.8	0.5	0.6	-0.4
Arm fat percentage (left)	0.4	1.6	2.6	1.4	1.4	1.1	1.6	0.6
Commuting to job workplace: Walk	0.4	0.4	1.1	-0.5	0.0	-1.0	-0.7	0.2
Asthma (self-reported)	0.4	0.9	2.0	0.8	1.4	0.5	0.9	-0.7
Smoking status: Current	0.4	0.7	1.5	-0.3	-1.2	-0.4	-1.0	-0.7
Miserableness	0.4	0.7	1.7	-1.0	-0.5	-1.3	-0.7	0.5
Illnesses of father: High blood pressure	0.4	0.5	2.3	0.2	-0.2	0.4	0.2	-1.5
Alcohol drinker status: Never	0.4	0.4	1.2	-0.7	-0.3	0.6	-0.1	1.1
Leg fat percentage (left)	0.4	1.3	2.1	1.3	1.3	1.1	1.4	-0.1
Impedance of whole body	0.4	1.8	6.5	0.2	1.1	1.0	0.6	2.5
Bipolar Disorder (2018)	0.3	0.5	1.6	0.7	0.3	0.1	0.3	-1.3
Irritable Bowel Disease (IBD)	0.3	0.7	1.2	-0.8	-0.5	-1.1	-0.8	1.0
Primary Biliary Cirrhosis	0.3	0.4	1.5	-0.4	-0.7	-1.2	-0.1	-0.3
Rheumatoid Arthritis	0.3	0.4	0.6	0.3	0.7	-0.7	0.7	0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.6	0.7	0.7	0.4	0.7	-0.3
Tanning	0.3	3.1	6.3	1.9	2.5	0.2	2.2	-0.9
Systolic blood pressure, automated reading	0.3	0.8	1.6	0.7	1.3	-0.9	1.0	-0.4
Medication: Metformin	0.3	0.5	1.0	0.5	1.0	0.9	0.5	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	0.6	0.4	1.0	0.3	-0.6
Past tobacco smoking	0.3	0.5	0.8	0.6	0.2	-0.9	0.6	-0.9
Nervous feelings	0.3	0.6	1.0	-0.5	-0.7	-1.0	-0.6	0.8
Heart attack	0.3	0.4	0.9	-0.5	0.6	-0.7	-0.1	1.0
Mouth/teeth dental problems: Dentures	0.3	0.5	1.9	-0.1	0.0	0.6	-0.2	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.0	-0.5	-1.0	-0.2	-0.8	-0.1
Blood clot in the leg (DVT)	0.3	0.4	1.1	-0.2	-0.0	-1.0	-0.4	0.7
Arm fat-free mass (right)	0.3	1.7	6.0	-0.3	-1.5	-0.1	-0.5	-2.5
Comparative body size at age 10	0.3	0.8	1.5	-0.1	-1.2	0.4	-1.0	-1.0
Number of children fathered	0.3	0.4	0.7	-0.6	-0.0	0.8	-0.8	0.6
Medication: Allopurinol	0.3	0.4	1.1	-0.6	-0.8	-1.1	-0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.6	0.5	0.7	0.8	0.4	0.6
Leg fat mass (right)	0.3	1.1	2.0	1.2	0.9	1.0	1.4	-0.5
Arm predicted mass (right)	0.3	1.7	5.4	-0.4	-1.6	-0.3	-0.6	-2.3
Number of full sisters	0.3	0.4	0.6	0.8	0.6	0.2	0.6	-0.7
Overall health rating	0.3	0.6	1.5	-0.3	-1.1	-1.2	-0.5	-0.3
Chest pain or discomfort	0.3	0.4	1.2	-0.4	-0.4	-1.1	-0.8	0.1
Supplements: Vitamin C	0.3	0.3	1.0	0.8	-0.0	1.0	-0.1	0.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.0	0.7	0.4	0.6	1.0	-0.4
Osteoporosis (self-reported)	0.3	0.4	1.5	0.4	-0.4	1.2	-0.0	-0.1
Arm fat mass (left)	0.3	1.2	2.2	1.4	0.9	0.9	1.5	-0.4
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	0.0	0.5	0.9	0.3	0.9
Medication: Paracetamol	0.3	0.5	1.7	0.3	0.6	-0.6	-0.0	1.3
Arm fat-free mass (left)	0.3	1.6	5.6	-0.3	-1.5	-0.1	-0.6	-2.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	-0.5	0.5	-0.9	-0.2	0.8
Arm predicted mass (left)	0.3	1.5	5.2	-0.3	-1.4	-0.4	-0.5	-2.3
Crohns Disease (2017)	0.2	0.3	0.5	0.5	0.7	0.6	0.1	0.7
Height	0.2	4.1	6.1	-2.4	-2.0	0.0	-2.2	2.5
Hypothyroidism (self reported)	0.2	0.4	0.7	-0.4	-0.3	-0.8	-0.9	0.7
Lung FVC	0.2	0.9	2.5	-0.6	-1.6	0.3	-1.2	0.1
Average weekly spirits intake	0.2	0.3	0.8	-0.6	0.3	-0.3	-0.3	0.9
Sensitivity / hurt feelings	0.2	0.3	0.7	0.7	-0.2	0.1	0.4	-0.8
Diabetes (father)	0.2	0.3	0.7	-0.4	-0.2	-0.9	-0.2	0.5
Impedance of leg (right)	0.2	0.7	1.2	0.5	1.0	0.7	0.9	1.1
Body mass index (BMI)	0.2	0.7	1.1	1.1	0.6	0.4	1.0	-0.8
Trunk fat mass	0.2	0.9	1.4	0.8	0.8	1.1	1.2	0.5
Waist circumference	0.2	0.9	1.5	0.8	0.9	1.1	1.2	-0.0
Number of incorrect matches in round	0.2	0.4	0.7	0.5	0.6	-0.8	0.5	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.8	-0.6	-0.1	0.1	-0.3	0.9
Qualifications: None of the above	0.2	0.5	1.1	1.0	0.6	0.0	0.9	0.2
Diabetes (self-reported)	0.2	0.4	1.1	0.4	0.4	1.1	0.3	-0.6
Medication: Ramipril	0.2	0.3	0.6	-0.5	-0.8	-0.0	-0.7	0.1
Neuroticism score	0.2	0.4	0.8	0.9	0.5	0.7	0.4	-0.3
Trunk fat-free mass	0.2	1.3	5.1	-0.1	-1.1	-0.4	-0.3	-2.2
Hip circumference	0.2	0.7	1.5	1.2	0.8	0.7	1.0	-0.2
Noisy workplace	0.2	0.3	0.8	-0.4	0.5	0.2	0.4	0.9
Depression (self-reported)	0.2	0.2	0.7	0.2	-0.2	-0.8	-0.3	0.4
Arm fat mass (right)	0.2	1.0	1.8	1.2	0.8	0.8	1.4	-0.4
Trunk predicted mass	0.2	1.3	5.0	-0.2	-1.1	-0.3	-0.3	-2.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	-0.7	0.0	-0.5	-0.1	0.5
Headache pain in last month	0.2	0.3	0.6	0.7	0.1	-0.5	0.6	-0.7
Gout (self-reported)	0.2	0.3	1.2	-0.5	-0.3	-1.1	0.3	-0.0
Medication: Amlodipine	0.2	0.3	0.7	0.2	0.2	0.9	-0.1	-0.7
Forced vital capacity (FVC), Best measure	0.2	0.7	2.2	-0.8	-1.5	-0.1	-0.9	-0.0
Worry too long after embarrassment	0.2	0.4	0.7	0.7	0.4	0.8	0.4	-0.7
Whole body fat mass	0.2	1.0	1.8	1.1	0.9	1.1	1.3	0.0
Comparative height size at age 10	0.2	1.3	3.2	-1.3	-1.8	-0.3	-1.1	-0.4
Suffer from ‘nerves’	0.2	0.3	0.7	0.2	0.0	0.5	-0.6	0.8
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.0	-0.0	-1.0	0.3	-0.1	-0.6
Whole body fat-free mass	0.2	1.3	5.2	0.0	-1.0	-0.1	-0.2	-2.3
Mood swings	0.2	0.3	0.9	0.7	0.3	0.3	0.4	-0.9
Ever had bowel cancer screening	0.2	0.2	0.6	0.3	0.5	-0.8	0.5	0.1
Mineral and other dietary supplements	0.2	0.2	0.5	-0.3	-0.4	-0.5	-0.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.0	1.0	0.5	-0.2	0.9	0.3
Whole body water mass	0.2	1.2	4.4	-0.1	-1.1	-0.2	-0.4	-2.1
Hearing aid user	0.2	0.2	1.1	0.2	0.2	-1.0	0.1	0.1
Basal metabolic rate	0.2	1.0	4.3	0.2	-0.8	0.1	0.0	-2.1
Age started oral contraceptive pill	0.2	0.2	0.9	-0.1	0.3	0.1	0.1	0.9
Ever depressed for a whole week	0.2	0.3	1.0	0.0	-0.1	-0.6	-0.4	-1.0
Unable to work because of sickness or disability	0.2	0.3	1.0	-0.3	-0.4	-1.0	-0.6	0.1
Supplements: Calcium	0.2	0.2	0.9	0.9	0.1	0.1	0.5	0.0
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	0.2	-0.5	0.4	-0.1	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.0	0.1	0.2	-1.0	-0.1	0.6
Pack years of smoking	0.2	0.3	1.2	-0.0	-0.4	-1.1	-0.2	-0.4
Leg fat mass (left)	0.2	0.8	1.4	1.0	0.8	1.0	1.2	-0.5
Depression (Nagel 2018)	0.1	0.1	0.2	-0.3	0.0	0.3	-0.2	0.4
Schizophrenia vs Biploar Disorder	0.1	0.2	0.7	0.2	0.1	-0.4	0.1	-0.8
Ovarian Cancer	0.1	0.2	0.3	0.4	0.2	0.6	0.4	0.6
HDL Cholesterol	0.1	0.2	0.6	0.4	0.8	0.4	0.2	0.5
Heel T-Score	0.1	0.7	1.3	0.1	0.1	1.1	-1.1	-1.0
BMI	0.1	0.9	2.2	1.0	0.2	1.5	0.9	-0.6
Allergy or Eczema	0.1	0.3	0.8	-0.3	-0.6	0.9	-0.6	0.1
Neuroticism	0.1	0.2	0.7	0.8	0.4	0.4	0.3	0.1
Hand grip strength (left)	0.1	0.2	0.5	-0.3	-0.1	0.3	0.1	-0.7
Hearing difficulty/problems: Yes	0.1	0.2	0.5	0.3	-0.7	0.2	-0.7	-0.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	0.3	-0.3	-0.7	-0.2	0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.4	-0.3	-0.2	0.6	-0.6	-0.2
Leg fat-free mass (left)	0.1	0.6	2.5	0.2	-0.7	0.1	-0.0	-1.6
Hand grip strength (right)	0.1	0.2	0.4	-0.7	-0.0	-0.4	-0.0	-0.5
Age when periods started (menarche)	0.1	0.1	0.3	0.3	0.5	0.2	0.6	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.6	0.1	-0.6	-0.2	-0.1	-0.8
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.4	-0.7	-0.6	-0.3	-0.6	0.5
Medication: Levothyroxine sodium	0.1	0.2	0.5	0.7	0.5	0.6	0.3	-0.2
Impedance of leg (left)	0.1	0.6	1.0	0.4	1.0	0.8	0.7	1.0
Leg predicted mass (left)	0.1	0.7	2.7	0.3	-0.7	0.2	0.1	-1.6
Had menopause	0.1	0.2	0.5	-0.4	-0.2	-0.4	-0.1	0.7
Forced vital capacity (FVC)	0.1	0.3	1.1	-0.4	-1.0	0.2	-0.6	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	0.1	-0.7	-0.4	0.1	-0.9
Allergy	0.1	0.2	0.6	0.4	-0.4	0.4	0.2	-0.8
Fluid intelligence score	0.1	0.3	1.0	-0.3	0.3	-0.1	-0.2	1.0
Weight	0.1	0.3	0.4	0.6	0.1	0.6	0.7	-0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.4	-0.6	-1.2	0.3	-0.7	0.2
Medication: Lansoprazole	0.1	0.1	0.5	0.1	-0.1	0.2	-0.1	-0.7
Lung cancer (father)	0.1	0.1	0.4	0.3	-0.0	0.6	0.3	-0.2
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.8	-0.4	-0.2	-0.5	0.5
High blood pressure (siblings)	0.1	0.1	0.4	0.1	-0.4	0.6	0.1	-0.0
Wheeze or whistling in the chest in last year	0.1	0.3	1.1	-0.2	-0.2	-0.0	-0.4	-1.0
Eye problems/disorders: None of the above	0.1	0.2	0.4	-0.4	-0.3	0.3	-0.2	0.7
Illnesses of siblings: Diabetes	0.1	0.2	0.5	0.7	0.1	-0.4	0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	0.3	-0.3	0.4	-0.0	-0.7
Leg fat-free mass (right)	0.1	0.8	3.1	0.1	-0.8	0.1	-0.2	-1.8
Long-standing illness, disability or infirmity	0.1	0.2	0.6	0.1	-0.2	0.4	0.2	-0.8
Qualifications: nursing, teaching	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.5	-0.3
Eye problems/disorders: Cataract	0.1	0.1	0.3	0.2	0.5	-0.5	0.0	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.4	0.4	0.3	0.6	0.3	0.2
Leg predicted mass (right)	0.1	0.8	3.3	0.1	-0.8	0.2	-0.1	-1.8
Guilty feelings	0.1	0.1	0.4	0.1	-0.6	-0.4	-0.2	-0.0
Wears glasses or contact lenses	0.1	0.1	0.1	0.0	-0.2	-0.4	-0.3	-0.2
Medication: Atorvastatin	0.1	0.2	0.4	0.0	0.3	-0.6	0.6	-0.2
Ever smoked	0.1	0.2	0.4	-0.2	-0.4	0.5	-0.6	-0.1
Diastolic blood pressure, automated reading	0.1	0.2	0.5	0.4	0.4	-0.7	0.2	-0.3
Cholesterol lowering medication	0.1	0.2	0.4	-0.3	-0.2	-0.4	0.2	0.6
Neuroticism (Nagel 2018)	0.0	0.1	0.3	-0.1	-0.3	0.3	-0.5	-0.0
Blood Eosinophil Count	0.0	0.3	1.4	0.1	0.1	-0.1	-0.1	1.2
Waist Hip Ratio (WHR)	0.0	0.2	0.5	-0.3	0.0	0.7	0.5	0.1
Hair Pigment	0.0	0.2	0.5	0.3	0.5	0.1	0.6	0.7
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	-0.1	0.3	-0.0	0.1	0.0
Sitting height	0.0	0.3	0.6	-0.7	-0.8	-0.4	-0.5	0.2
Illnesses of siblings	0.0	0.0	0.1	-0.2	0.4	0.0	-0.0	-0.1
Standing height	0.0	0.4	0.7	-0.8	-0.8	0.4	-0.4	0.4
Irritability	0.0	0.0	0.1	0.0	-0.0	-0.1	-0.2	-0.3

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