Hub : Genes

KLB

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.5280 0.0430 0.00000 0.467 0.456 0.514 0.514 0.511 1.0e-63 1.1e-61 9.6e-73 1.2e-72 4.9e-72
2 METSIM Adipose 0.0775 0.0279 0.00045 0.026 0.015 0.027 0.016 0.036 7.7e-05 2.0e-03 5.3e-05 1.6e-03 3.7e-06
3 NTR Blood 0.0291 0.0121 0.00140 0.014 0.011 0.022 0.013 0.020 2.3e-05 1.2e-04 6.9e-08 3.1e-05 3.5e-07
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0290 0.0161 0.00800 0.002 0.005 0.002 NA 0.005 1.8e-01 7.1e-02 1.6e-01 NA 9.0e-02
5 TCGA Kidney Renal Papillary Cell Carcinoma 0.1050 0.0510 0.00056 0.068 0.048 0.005 NA 0.044 9.3e-05 9.8e-04 1.6e-01 NA 1.6e-03
6 TCGA Brain Lower Grade Glioma 0.3411 0.0592 0.00000 0.344 0.342 0.361 NA 0.357 1.9e-40 4.0e-40 7.7e-43 NA 2.8e-42
7 TCGA Liver Hepatocellular Carcinoma 0.1060 0.0440 0.00038 0.070 0.042 0.014 NA 0.045 3.2e-04 4.4e-03 7.0e-02 NA 3.4e-03
8 TCGA Thyroid Carcinoma 0.0590 0.0280 0.00086 0.036 0.020 0.038 NA 0.047 1.9e-04 4.2e-03 1.1e-04 NA 2.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.8 1.3 4.0 0.6 0.1 -1.2 1.9 2.0 0.1 -0.9 0.4
Bipolar Disorder or Schizophrenia 0.6 1.5 3.1 1.6 0.2 0.3 1.4 1.2 1.1 -1.5 1.8
Depressed Affect (Nagel 2018) 0.6 1.2 3.6 -0.9 0.2 -0.0 -0.3 1.7 -1.9 -0.1 -1.5
Depression (Nagel 2018) 0.8 1.2 2.7 -1.0 -0.9 -0.6 -0.0 1.6 -1.5 0.7 -1.2
Intelligence (Savage-Jansen 2018) 1.7 5.2 14.7 -1.0 0.7 -2.8 3.1 3.8 -1.8 -1.6 -1.4
Neuroticism (Nagel 2018) 1.0 2.3 7.0 -1.7 0.3 -0.7 0.2 1.8 -2.6 0.4 -2.2
Schizophrenia (2018) 0.6 1.3 3.6 1.6 0.1 1.3 0.3 -0.1 1.3 -1.1 1.9
Schizophrenia vs Biploar Disorder 1.4 1.8 8.3 0.8 1.6 2.9 0.0 -1.0 0.9 -0.0 0.9
Worry (Nagel 2018) 0.2 0.5 1.6 0.2 -0.7 0.1 1.1 1.3 -0.5 -0.7 -0.2
Alzheimer’s Disease (in mother) 1.3 1.5 5.0 -0.9 -0.6 -0.4 -2.2 -1.7 -0.6 1.5 -0.6
Alzheimer’s Disease (in father) 0.3 0.3 0.8 -0.7 -0.2 -0.9 -0.0 -0.3 -0.4 0.8 -0.5
Alzheimer’s Disease (including proxy) 0.8 1.1 3.4 -0.5 -0.4 -1.0 -1.8 -1.8 0.0 1.0 -0.1
Crohns Disease (2017) 3.5 7.7 14.3 -3.8 1.3 0.3 -2.1 -1.7 -3.4 3.7 -3.6
Irritable Bowel Disease (IBD) 2.9 6.9 13.8 -3.5 1.0 -0.3 -1.9 -2.2 -3.0 3.7 -3.2
Ulcerative Colitis (UC) 0.7 1.2 2.6 -1.4 0.7 -0.4 -0.3 -1.5 -1.1 1.6 -1.1
Major Depression (MDD) 0.3 0.3 0.6 0.2 -0.6 -0.8 0.8 0.7 -0.0 -0.7 0.1
Reaction Time 0.7 1.3 2.5 1.5 -0.4 1.0 0.2 0.3 1.6 -1.3 1.5
Verbal and Numeric Reasoning (VNR) 1.7 4.0 10.3 -1.0 0.7 -2.1 3.1 3.2 -1.7 -1.3 -1.4
Breast Cancer 1.1 2.6 6.1 2.0 -0.3 1.2 -0.5 -0.8 2.5 -1.6 2.4
Ovarian Cancer 2.1 2.8 4.4 -2.1 -1.9 -1.9 -1.1 -0.6 -1.6 1.3 -2.0
Prostate Cancer 1.1 1.6 4.1 -1.0 -0.2 -0.9 2.0 1.9 -1.3 0.3 -1.3
Age at First Birth 0.8 1.2 5.0 -0.3 0.4 -2.2 2.1 0.3 0.1 -0.2 0.1
Bipolar Disorder (2011) 1.2 1.2 2.4 -0.9 0.8 -1.6 0.8 1.4 -1.3 0.0 -1.2
Body Mass Index (BMI) (2010) 0.2 0.3 0.9 -0.4 0.1 0.0 -0.9 -0.7 -0.3 0.5 -0.3
Coronary Artery Disease (CAD) 2.0 2.4 4.8 -2.2 -0.1 -0.4 -1.2 -0.5 -1.9 2.1 -2.2
Crohns Disease (2012) 4.5 7.3 13.6 -3.7 1.9 0.3 -2.1 -1.7 -3.3 3.2 -3.6
Mean Putamen Volume 1.3 1.5 3.7 1.2 1.2 0.6 1.3 1.9 0.8 -1.3 0.8
Fasting Glucose 1.2 1.5 2.9 -1.2 -0.4 0.5 -1.7 -1.5 -1.2 1.4 -1.2
HbA1C 0.4 0.5 2.2 0.1 1.5 0.8 0.7 0.5 -0.3 -0.1 0.2
HDL Cholesterol 0.6 1.1 2.1 0.8 -0.9 -1.5 -1.1 -1.1 1.1 -0.4 1.0
LDL Cholesterol 1.9 3.0 7.7 -1.9 -0.2 0.5 -1.6 -2.6 -1.2 2.8 -1.4
Lupus 0.3 0.5 1.5 -0.6 0.8 -0.1 -1.2 -0.7 -0.3 0.7 -0.3
Neuroticism (2016) 0.7 1.1 2.8 -1.0 -0.6 -0.2 -0.9 0.3 -1.7 1.0 -1.5
Primary Biliary Cirrhosis 0.4 0.6 1.3 -0.8 -0.7 -0.7 -0.4 -0.3 -1.1 0.5 -1.1
Rheumatoid Arthritis 1.8 2.5 9.1 -1.6 -2.1 -3.0 -0.4 -0.0 -1.1 1.0 -1.2
Schizophrenia (2014) 0.4 0.8 2.1 1.0 -0.1 1.5 0.1 -0.4 0.9 -0.6 1.3
Triglycerides 0.9 1.5 2.8 1.7 0.7 1.6 0.3 0.9 1.2 -1.6 1.2
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.6 0.3 -0.7 0.8 0.5 0.6 -0.0 -0.5 0.1
Ulcerative Colitis 1.0 1.4 3.4 -1.0 1.4 0.2 -1.2 -1.4 -0.8 1.8 -0.8
Blood Eosinophil Count 0.5 4.0 9.1 2.0 -2.0 -3.0 0.7 1.1 1.8 -2.3 2.0
Blood Platelet Count 0.7 8.1 18.1 -3.8 1.5 -1.3 -1.6 -0.7 -4.0 3.0 -4.3
Blood Red Count 0.8 8.0 34.0 -0.1 -0.9 -0.4 5.8 5.0 -1.2 -1.2 -0.5
Blood White Count 0.4 3.0 7.1 1.9 -2.7 2.3 0.0 -0.1 1.9 -1.2 1.7
Heel T-Score 0.4 3.4 12.5 -1.1 -3.5 -2.6 2.2 0.6 -1.1 -0.3 -0.7
BMI 0.1 0.8 2.3 1.1 0.2 -0.4 -0.3 -0.8 1.5 -0.6 1.5
Height 0.5 10.5 37.5 -1.3 2.2 -1.3 4.0 6.1 -3.5 -1.8 -2.6
Waist Hip Ratio (WHR) 0.4 2.0 5.5 -0.1 -2.0 -0.1 -2.2 -2.3 0.1 0.9 0.3
Systolic Blood Pressure 0.5 2.4 11.8 -0.4 -3.4 -0.4 0.5 -2.5 0.3 0.8 0.0
Smoking Status 2.0 4.9 9.0 3.0 0.1 2.8 0.4 1.4 2.7 -2.4 2.6
Allergy or Eczema 0.7 1.9 3.4 -1.4 -1.8 -1.4 -0.7 0.4 -1.7 1.4 -1.5
Cardiovascular Disease 0.2 0.7 1.8 -0.6 -1.3 -0.8 -0.3 -0.8 -0.4 1.2 -0.7
Hypothyroidism (self reported) 0.2 0.6 1.7 0.6 0.4 -1.3 -0.7 -0.6 0.9 0.0 0.7
Respiratory disease 0.2 0.4 2.3 -0.3 0.2 -0.4 -1.5 -0.1 -0.2 0.3 -0.3
Type 2 Diabetes (T2D) (2018) 0.7 1.4 2.5 1.6 -1.1 1.0 0.5 0.3 1.3 -1.4 1.6
Lung FEV1/FVC ratio 0.3 1.3 3.8 -0.4 1.2 -1.1 1.3 1.9 -1.0 -1.2 -0.4
Lung FVC 0.2 1.0 3.7 0.6 1.1 1.9 0.9 -0.0 0.5 -1.3 0.5
Neuroticism 1.0 2.3 5.5 -1.1 -0.5 -1.3 1.2 2.4 -2.2 -0.7 -1.7
Chronotype (morning person) 1.2 2.7 6.0 -2.4 -0.2 -1.4 1.0 0.4 -2.5 1.3 -2.2
Hair Pigment 0.0 0.7 3.9 -0.3 2.0 0.3 -1.0 -0.7 -0.3 0.4 -0.3
Tanning 0.1 1.3 2.6 -1.3 0.4 0.0 -1.6 -0.6 -1.1 1.6 -1.4
Hand grip strength (left) 2.2 5.7 10.6 2.5 0.8 1.4 3.2 3.2 1.7 -3.2 1.8
Number of treatments/medications taken 0.3 0.5 1.8 -0.3 -0.4 -1.3 0.9 0.7 -0.5 -0.1 -0.4
Average weekly spirits intake 0.7 0.9 4.0 -0.6 0.4 -2.0 0.7 1.3 -0.1 0.6 -0.4
Sensitivity / hurt feelings 1.1 1.9 5.0 -1.9 -0.2 -0.7 0.3 0.7 -2.2 1.4 -1.8
Frequency of depressed mood in last 2 weeks 0.4 0.5 2.0 -0.3 -0.9 0.0 0.6 1.4 -0.7 0.1 -0.4
Hearing difficulty/problems: Yes 0.4 0.5 1.7 0.6 0.2 -0.1 1.1 0.9 0.1 -1.3 0.5
Relative age of first facial hair 0.7 1.4 3.5 -0.6 1.4 -0.1 -1.6 -1.9 0.0 1.6 -0.4
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 3.4 1.2 -0.9 0.1 1.8 0.4 0.9 -1.3 1.2
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.8 -0.7 0.7 -0.3 0.4 -0.3 -0.9 -0.3 -0.6
Ever had hysterectomy (womb removed) 1.6 1.8 3.3 -1.6 0.6 -0.9 -1.1 0.2 -1.6 1.7 -1.8
Systolic blood pressure, automated reading 0.3 1.0 3.1 -0.6 -1.8 -1.1 0.3 -1.6 0.0 1.0 -0.1
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.8 -0.8 0.1 0.6 -1.3 -0.6 -0.9 0.9 -0.9
Angina 1.4 1.9 8.5 -0.4 -0.6 1.5 -2.9 -1.4 -0.1 1.2 -0.3
Medication for hormone replacement therapy 0.4 0.5 1.2 0.6 -0.2 0.2 0.0 -1.0 1.0 0.0 1.1
Vitamin and mineral supplements 0.5 0.7 2.3 0.5 -0.8 1.1 -1.5 -0.8 0.4 -0.1 0.4
Supplements: Zinc 0.2 0.2 0.5 -0.6 0.6 -0.1 -0.2 -0.1 -0.6 0.7 -0.2
Medication: Co-codamol 0.8 0.9 4.3 0.6 2.1 1.1 0.3 0.6 0.3 -0.8 0.6
Medication: Metformin 1.9 2.7 5.5 1.9 0.1 1.4 1.5 1.5 1.6 -2.3 1.9
Diabetes (father) 0.6 0.7 4.6 0.4 -2.2 0.2 0.2 0.8 0.2 -0.2 0.1
Diabetes (mother) 0.9 1.1 1.6 1.2 -1.3 0.6 1.3 0.9 0.8 -1.2 1.1
Severe depression (siblings) 0.1 0.1 0.3 0.2 -0.3 0.4 0.6 0.2 -0.0 -0.5 0.2
Pack years adult smoking proportion 1.0 1.5 3.0 1.3 -0.2 1.6 0.8 1.2 0.9 -1.7 1.4
Impedance of leg (right) 1.2 5.8 11.2 -2.5 -2.2 0.7 -3.0 -3.4 -2.0 2.1 -2.5
Leg fat-free mass (left) 0.6 3.1 9.1 1.3 1.1 -0.9 2.6 3.0 0.6 -1.9 1.2
Trunk fat percentage 0.4 1.6 4.7 -1.3 0.2 -1.1 -1.6 -2.2 -0.8 1.2 -0.5
Hand grip strength (right) 2.8 7.6 19.1 2.6 0.1 1.2 4.0 4.4 1.5 -3.6 1.8
Townsend deprivation index at recruitment 0.4 0.6 2.5 0.6 0.2 1.6 -0.8 -0.3 0.5 -0.3 0.8
Current tobacco smoking 1.5 2.5 4.9 2.2 -0.3 2.0 -0.2 1.1 1.9 -1.4 2.1
Average weekly fortified wine intake 0.5 0.6 2.0 -0.4 0.6 0.2 0.7 1.4 -1.0 -0.2 -0.8
Maternal smoking around birth 0.5 0.8 2.1 -0.5 -0.8 1.3 -1.5 -0.1 -0.2 1.0 -0.4
Fed-up feelings 0.4 0.7 3.6 0.3 -1.9 0.7 -0.1 1.0 -0.4 -0.6 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 2.1 -0.0 -0.9 1.0 -0.2 1.4 -0.5 -0.1 0.0
Relative age voice broke 1.2 1.8 4.5 -1.1 1.7 -0.0 -1.6 -1.6 -0.4 2.1 -0.7
Taking other prescription medications 0.3 0.4 1.6 -0.6 -0.2 -0.5 -1.3 -0.5 -0.6 0.1 -0.5
Age when periods started (menarche) 0.4 1.1 2.7 1.0 -0.4 1.6 -0.9 -0.7 1.0 -0.6 1.4
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 9.7 -0.0 1.3 3.1 -0.1 -0.3 -0.3 0.3 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.6 5.6 -1.9 -2.3 -0.8 0.4 -0.7 -2.4 0.7 -2.1
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 4.0 0.9 -1.4 2.0 -0.1 -0.8 1.0 -0.3 0.9
Qualifications: CSEs or equivalent 2.4 3.2 7.0 -2.4 -1.5 -0.4 -1.4 -0.8 -2.7 1.3 -2.4
Serious illness, injury or assault to yourself 0.8 1.0 2.5 0.2 -1.6 -1.1 -0.4 -1.6 0.4 -1.1 0.2
High blood pressure 0.3 0.9 2.0 0.9 -1.3 -0.4 1.4 1.3 0.8 -0.4 0.8
Hayfever, allergic rhinitis or eczema 0.6 1.2 6.4 -0.5 -2.5 -0.5 0.1 1.1 -0.8 0.3 -0.8
Multivitamins +/- minerals 0.4 0.5 1.5 -0.5 1.2 -0.8 0.7 0.3 -0.4 0.8 -0.3
Stomach or abdominal pain in last month 0.4 0.5 1.3 0.6 0.8 1.1 -0.4 0.3 0.3 -0.9 0.4
Supplements: Glucosamine 1.0 1.3 6.3 -0.8 -0.8 -2.5 1.2 0.6 -0.7 0.5 -0.4
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.3 -0.3 0.6 1.1 0.1 0.6 -0.6 -0.5 -0.9
Medication: Atenolol 0.5 0.6 2.8 -0.7 -0.7 -0.2 -0.7 -1.7 -0.5 0.4 -0.4
Medication: Levothyroxine sodium 0.5 0.8 4.6 -0.6 -0.4 -2.1 -0.6 -0.5 -0.3 0.6 -0.2
Sitting height 0.3 1.9 5.7 -0.3 1.7 -1.1 1.4 2.4 -0.9 -1.1 -0.8
Chronic bronchitis/emphysema (father) 1.4 1.7 3.9 1.5 -0.3 0.3 1.3 1.2 1.4 -2.0 1.4
High blood pressure (mother) 1.0 1.5 6.8 0.5 -2.6 1.5 -1.4 -0.2 0.4 -0.2 0.2
Body mass index (BMI) 0.1 0.3 0.9 -0.4 1.0 -1.0 -0.4 -0.4 -0.2 0.5 0.1
Impedance of leg (left) 1.1 5.4 10.8 -2.4 -1.7 1.2 -2.7 -3.3 -2.1 2.1 -2.5
Leg predicted mass (left) 0.6 3.0 9.0 1.2 1.2 -0.9 2.5 3.0 0.5 -1.9 1.2
Trunk fat mass 0.1 0.5 1.1 -0.8 0.5 -0.9 -0.6 -1.0 -0.6 0.5 -0.2
Waist circumference 0.0 0.2 0.8 -0.3 0.3 -0.9 -0.1 -0.1 -0.4 0.0 0.1
Number of incorrect matches in round 2.0 3.4 6.1 1.8 2.5 1.6 -2.0 -0.0 2.4 0.5 2.2
Past tobacco smoking 0.6 1.1 2.1 -1.2 -0.8 -1.1 0.6 0.6 -1.5 0.6 -1.3
Alcohol usually taken with meals 0.8 1.2 4.4 -0.7 -2.1 -1.9 0.8 0.0 -0.4 0.3 -0.7
Nervous feelings 0.3 0.6 2.3 0.1 -1.5 1.1 0.4 0.7 -0.4 -0.3 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 2.0 1.0 -1.4 1.3 -0.0 1.1 0.6 -0.7 0.9
Hearing difficulty/problems with background noise 0.8 1.2 2.6 1.4 0.9 0.4 0.5 0.7 1.2 -1.6 1.5
Hair/balding pattern: Pattern 2 2.4 3.1 5.5 -2.2 -0.1 -0.9 -2.1 -1.8 -2.1 1.3 -2.4
Had menopause 1.1 1.4 2.7 -1.7 -0.0 -1.5 0.4 -0.1 -1.6 1.1 -1.4
Had other major operations 2.1 2.6 6.9 -1.4 -0.1 -1.5 -2.4 -2.6 -0.9 1.5 -1.1
Forced vital capacity (FVC) 0.2 0.8 2.1 0.6 0.7 1.0 1.4 0.8 0.3 -1.4 0.2
Heel bone mineral density (BMD) T-score, automated (right) 1.6 3.7 9.6 -2.7 -1.6 -1.0 0.1 -1.2 -3.1 1.3 -2.5
Ever unenthusiastic/disinterested for a whole week 1.4 1.7 5.6 1.0 -0.7 -0.2 2.4 1.2 0.5 -1.9 0.8
Qualifications: None of the above 0.4 0.8 2.9 0.4 0.1 1.6 -1.7 -0.5 0.1 -0.1 0.4
Financial difficulties in last 2 years 1.4 1.9 4.0 1.4 -1.3 2.0 -0.0 -1.2 1.6 -0.4 2.0
Mouth/teeth dental problems 1.0 1.5 3.1 1.8 0.4 1.6 -0.2 0.4 1.6 -1.2 1.3
Heart attack 0.2 0.3 1.2 -0.3 -0.4 0.6 -1.1 0.1 -0.3 0.2 -0.4
Allergy 0.2 0.6 3.4 0.1 1.8 0.2 -0.0 -0.8 0.2 0.4 0.5
Pain all over the body in last month 0.2 0.2 0.5 0.6 0.1 -0.7 -0.1 -0.2 0.6 -0.4 0.7
Diabetes (self-reported) 0.1 0.2 1.1 0.1 -0.2 1.0 0.0 -0.1 -0.0 -0.4 0.1
Hayfever/allergic rhinitis (self-reported) 1.4 1.8 4.1 -1.2 -2.0 -1.0 -1.5 -0.5 -1.3 1.3 -1.4
Medication: Ramipril 0.7 0.9 1.4 1.0 -0.6 1.1 0.2 -1.2 1.1 -1.1 1.1
Medication: Simvastatin 0.9 1.3 3.1 -1.0 1.8 1.0 -1.3 -0.6 -0.9 1.4 -0.8
Fluid intelligence score 1.1 2.2 5.1 -1.1 0.2 -2.0 2.2 1.8 -1.6 -0.3 -1.3
Illnesses of siblings 0.6 0.8 2.6 -0.7 1.0 0.1 1.6 1.0 -0.8 0.6 -0.7
Neuroticism score 0.7 1.5 5.8 0.1 -1.2 0.2 1.7 2.4 -0.8 -1.1 -0.2
Weight 0.2 1.0 2.6 -0.1 1.3 -1.0 1.4 1.6 -0.6 -0.8 0.0
Impedance of arm (right) 0.2 1.1 4.3 -0.8 -1.2 -0.6 -1.1 -2.1 -0.3 0.2 -0.7
Arm fat percentage (right) 0.2 0.7 2.9 -0.6 0.3 -0.9 -1.0 -1.7 -0.1 0.8 0.2
Trunk fat-free mass 0.7 4.0 16.7 0.7 1.1 -0.1 3.2 4.1 -0.4 -1.8 0.3
Hip circumference 0.1 0.6 2.3 0.2 1.5 -0.4 1.0 1.0 0.1 -0.6 0.4
Time employed in main current job 0.7 0.8 3.6 0.5 -0.5 -1.9 0.4 1.1 0.6 -0.7 0.5
Alcohol intake versus 10 years previously 3.4 5.1 18.7 1.5 2.3 0.0 2.8 4.3 0.8 -2.1 1.2
Father’s age at death 0.7 0.9 1.9 -0.7 -0.7 -0.8 0.4 1.4 -1.2 0.3 -1.3
Worrier / anxious feelings 1.2 2.2 4.3 -2.0 0.2 -1.6 0.8 1.1 -2.1 1.5 -1.8
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 2.0 -0.7 -1.0 0.2 -0.7 0.3 -1.4 0.5 -0.9
Falls in the last year 0.6 0.8 2.0 -0.1 1.4 0.5 0.9 1.4 -0.7 -0.8 -0.4
Hair/balding pattern: Pattern 3 0.6 0.9 3.3 0.7 -1.0 1.8 0.5 -0.2 1.1 0.3 1.0
Number of live births 0.1 0.2 0.8 0.2 0.9 0.4 0.1 0.0 0.4 -0.2 -0.0
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 1.6 -0.1 1.1 0.5 1.3 1.2 -0.5 -1.1 -0.6
Pulse rate 0.2 0.3 1.8 -0.3 -1.4 -0.6 -0.1 0.2 -0.3 -0.1 -0.5
Happiness 1.1 1.4 4.4 -0.2 -2.1 -1.7 1.8 0.6 -0.4 -0.1 -0.1
Noisy workplace 2.4 3.0 7.2 2.0 -0.8 2.7 0.2 0.1 2.3 -1.7 1.9
Qualifications: A levels/AS levels or equivalent 0.9 2.0 9.1 0.1 0.7 -1.4 3.0 1.7 0.1 -1.2 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.6 2.2 -0.6 1.5 -0.6 0.7 0.1 -0.9 -0.2 -0.9
Mouth/teeth dental problems: Dentures 2.2 3.7 7.5 -2.6 0.5 -0.9 -1.3 -1.3 -2.4 2.7 -2.2
Asthma 0.1 0.2 0.7 -0.1 0.5 0.1 -0.9 0.2 -0.2 -0.2 -0.4
Medication: Ibuprofen (e.g. Nurofen) 2.0 2.5 5.5 1.5 0.2 -0.3 2.3 2.1 1.1 -2.2 1.5
Medication: Cholesterol lowering 0.4 0.6 1.4 -1.1 -0.9 -0.1 0.1 -0.1 -1.2 0.5 -1.1
Depression (self-reported) 1.3 1.6 4.2 0.3 0.4 0.9 2.0 2.0 -0.3 -1.8 0.4
Medication: Lansoprazole 0.5 0.6 2.0 0.5 1.4 0.9 -0.7 0.5 0.4 -1.0 0.1
Prospective memory result 1.6 2.0 5.5 1.5 1.0 2.3 -0.8 0.5 1.6 -1.2 1.6
Lung cancer (father) 0.4 0.5 2.7 0.1 -0.4 -1.6 0.5 0.7 0.0 0.2 0.1
Illnesses of mother 1.9 2.4 7.4 -0.4 2.2 -1.9 2.7 1.3 -0.6 -0.9 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 2.1 0.6 1.1 1.5 1.1 1.3 0.1 -1.3 0.1
Pulse wave Arterial Stiffness index 0.2 0.3 1.2 0.3 -1.1 0.5 0.1 -0.1 0.3 -0.7 0.4
Impedance of arm (left) 0.2 1.1 4.7 -0.5 -1.3 -0.7 -1.1 -2.2 0.1 0.2 -0.4
Arm fat mass (right) 0.1 0.2 0.7 -0.3 0.8 -0.8 -0.1 -0.4 -0.1 0.1 0.3
Trunk predicted mass 0.7 4.2 17.6 0.8 1.0 -0.0 3.3 4.2 -0.4 -1.9 0.3
Standing height 0.5 5.4 20.3 0.5 0.4 -0.1 3.7 4.5 -0.9 -2.7 -0.3
Length of working week for main job 0.6 0.7 3.4 0.6 0.7 1.9 0.4 0.6 0.4 -0.5 0.3
Exposure to tobacco smoke at home 0.9 1.1 2.8 -1.2 -0.5 -0.3 -1.7 0.0 -1.2 1.0 -1.1
Breastfed as a baby 0.4 0.5 2.3 -0.1 0.7 -0.8 1.5 0.1 0.1 0.5 0.0
Tense / ‘highly strung’ 0.1 0.2 1.2 -0.0 -0.0 0.3 1.1 0.4 -0.2 -0.1 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.7 7.3 -2.1 -0.3 -2.2 1.6 2.3 -2.7 0.2 -2.2
Hair/balding pattern: Pattern 4 0.6 1.5 5.9 1.1 0.8 -2.4 0.1 1.7 0.8 -0.6 0.9
Birth weight of first child 0.7 1.3 3.2 -1.3 -0.5 -0.3 -0.7 1.2 -1.8 0.7 -1.6
Peak expiratory flow (PEF) 0.8 1.8 4.1 1.4 0.3 0.9 1.4 2.0 1.2 -1.6 1.1
Pulse wave reflection index 1.0 1.2 3.6 1.2 0.2 1.9 0.2 -0.5 1.3 -0.6 1.4
Ever highly irritable/argumentative for 2 days 3.1 3.8 7.1 2.6 -0.4 2.1 0.9 1.1 2.2 -2.7 2.2
Loud music exposure frequency 1.2 1.4 4.3 -0.0 0.3 -2.1 1.4 1.4 -0.4 -1.4 -0.4
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 1.2 -0.3 0.1 -0.4 -0.9 -1.1 -0.0 0.2 -0.2
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.2 -0.4 -0.2 -0.8 1.1 -0.5 -0.3 -0.1 -0.1
Blood clot in the leg (DVT) 0.2 0.3 0.9 0.4 1.0 0.7 0.5 0.7 0.2 -0.4 -0.1
Medication: Paracetamol 0.3 0.5 2.1 -0.0 -0.3 -0.5 0.9 1.5 -0.4 -0.4 -0.5
Headache pain in last month 0.6 1.1 4.1 1.1 0.2 0.5 1.0 2.0 0.4 -1.1 0.6
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 4.5 -1.1 0.8 -0.7 -2.1 -0.6 -1.2 1.3 -1.3
Glaucoma (self-reported) 0.2 0.3 0.9 -0.1 -0.4 -1.0 -0.4 0.2 -0.3 0.9 -0.2
Gout (self-reported) 2.3 3.1 10.3 -0.5 -1.5 1.0 -3.2 -3.0 -0.1 1.5 -0.3
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 6.4 -0.4 -0.1 -2.5 -0.6 -0.8 -0.1 0.6 -0.1
Medication: Amlodipine 0.8 1.1 2.5 0.8 0.8 -0.4 1.3 1.5 0.6 -1.6 0.8
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.5 0.6 -0.3 -0.0 -0.3 0.5 0.7 -0.4 0.7
Birth weight 0.4 0.9 2.6 1.1 1.6 0.2 0.1 1.2 0.6 -1.1 0.4
Chronic bronchitis/emphysema (mother) 0.7 0.8 4.2 -0.5 0.3 -0.1 -2.0 -1.3 -0.2 0.2 -0.5
High blood pressure (siblings) 0.5 0.8 1.4 0.8 -1.0 0.4 -1.2 -1.2 0.9 -0.7 0.7
Forced vital capacity (FVC), Best measure 0.2 0.8 2.4 0.6 1.0 1.5 1.1 0.7 0.2 -1.1 0.2
Body fat percentage 0.6 2.2 7.0 -1.5 0.2 -0.9 -1.9 -2.6 -0.9 1.6 -0.7
Leg fat percentage (right) 0.9 3.3 9.3 -1.8 0.3 -0.4 -2.6 -3.0 -1.1 2.1 -1.0
Arm fat-free mass (right) 0.4 2.2 8.8 0.2 1.2 -0.3 2.4 3.0 -0.7 -1.0 -0.1
Exposure to tobacco smoke outside home 0.1 0.2 0.6 0.2 0.6 0.0 -0.7 -0.1 0.5 0.4 0.3
Comparative body size at age 10 2.1 5.7 9.1 3.0 1.4 2.2 1.8 2.0 2.7 -2.7 2.8
Number of full brothers 0.8 1.0 2.3 1.3 0.1 0.1 -0.8 -1.1 1.5 -0.5 1.5
Worry too long after embarrassment 0.9 1.5 6.0 0.9 -0.1 0.9 1.5 2.4 0.2 -1.2 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.5 1.9 4.6 -1.8 0.3 -1.1 -1.2 0.0 -2.1 1.1 -1.9
Wheeze or whistling in the chest in last year 0.6 1.1 2.1 1.1 1.4 1.1 -0.5 0.6 1.1 -0.8 1.2
Number of children fathered 0.7 0.8 2.5 -0.6 0.8 0.2 -1.0 -1.6 -0.4 1.1 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 2.7 3.1 16.8 -0.2 -0.6 0.2 -2.5 -4.1 0.4 1.1 0.2
Age at first live birth 0.3 0.6 3.0 -0.5 0.6 -1.7 -0.2 -0.1 -0.6 0.5 -0.7
Pulse wave peak to peak time 0.3 0.4 1.4 -0.4 1.2 -0.7 0.2 0.5 -0.5 0.5 -0.5
Health satisfaction 2.2 2.9 10.0 1.2 -3.2 0.4 -1.3 -2.2 1.6 -0.3 1.4
Shortness of breath walking on level ground 1.3 1.6 5.8 0.0 -1.5 0.8 -1.8 -2.4 0.5 0.6 0.5
Qualifications: College or University degree 0.8 2.5 8.2 -0.5 0.2 -2.2 2.9 2.3 -0.5 -0.3 -0.8
Eye problems/disorders: None of the above 0.6 0.7 4.9 -0.2 2.2 0.2 0.2 -0.3 -0.0 -0.4 -0.3
Mouth/teeth dental problems: Loose teeth 1.5 1.8 4.3 1.8 0.3 1.4 -0.0 -0.1 1.9 -1.1 2.1
Emphysema/chronic bronchitis 0.7 0.8 2.7 0.8 -0.7 0.2 1.2 0.6 0.5 -1.6 0.7
Medication for pain relief, constipation, heartburn 0.8 1.4 5.2 -0.9 0.8 -0.5 -1.2 -2.3 -0.4 1.6 -0.6
Neck or shoulder pain in last month 0.5 0.6 3.1 0.6 -0.5 0.6 -1.7 -0.8 0.6 -0.1 0.4
Medication: Blood pressure 1.9 3.3 6.2 2.1 -0.6 0.9 2.5 0.3 2.3 -2.2 2.1
Angina (self-reported) 1.6 2.2 10.4 -0.5 -0.7 1.3 -3.2 -1.5 -0.1 1.5 -0.4
Migraine (self-reported) 0.2 0.3 1.3 0.2 -0.3 -0.4 -1.1 -0.4 0.0 -0.6 -0.1
Medication: Ibuprofen 2.9 3.5 10.1 1.4 0.1 0.3 3.2 2.8 0.8 -2.4 1.3
Medication: Allopurinol 2.3 3.0 10.3 -0.7 -1.4 0.2 -2.9 -3.2 -0.4 1.5 -0.5
Medication: Omeprazole 0.4 0.4 1.6 0.7 -0.1 0.7 -0.2 0.6 0.4 -1.3 0.5
Medication: Seretide 50 evohaler 1.3 1.5 3.8 1.3 -1.8 1.1 0.5 0.2 1.0 -2.0 0.9
Mean time to correctly identify matches 1.3 2.4 5.1 2.1 0.4 1.1 0.8 0.5 2.2 -1.8 2.3
Heart disease (mother) 0.3 0.4 0.9 -0.4 -0.4 0.3 -1.0 -0.4 -0.6 0.9 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 4.9 1.1 -0.2 0.4 0.8 2.2 0.7 -1.7 0.5
Whole body fat mass 0.1 0.4 1.0 -0.8 0.6 -0.7 -0.6 -1.0 -0.6 0.5 -0.2
Leg fat mass (right) 0.1 0.5 1.6 -0.5 0.7 -0.1 -1.1 -1.3 -0.2 0.5 0.1
Arm predicted mass (right) 0.4 2.3 9.7 0.2 0.8 -0.2 2.4 3.1 -0.7 -1.2 -0.0
Pulse rate, automated reading 1.1 3.5 5.9 -2.4 -1.7 -1.0 -1.3 -1.8 -2.0 2.0 -2.3
Alcohol intake frequency. 7.6 17.7 76.5 1.9 2.5 -0.9 6.3 8.7 0.8 -3.5 1.4
Comparative height size at age 10 1.1 5.8 18.0 0.8 0.4 -1.2 4.2 4.1 -0.3 -3.1 0.4
Number of full sisters 0.6 0.7 2.2 -0.4 0.3 0.8 -1.5 -0.9 -0.5 1.2 -0.6
Suffer from ‘nerves’ 0.2 0.4 0.9 0.4 -0.4 0.9 0.6 0.7 -0.1 -0.9 0.0
Overall health rating 0.8 1.8 5.7 1.0 -0.5 1.7 -2.4 -1.5 1.0 -0.4 1.0
Chest pain or discomfort 1.1 1.6 2.5 1.4 -1.3 1.6 -1.4 -0.8 1.4 -0.4 1.5
Had major operations 1.7 2.0 6.2 0.6 -1.1 0.6 2.5 2.5 0.3 -1.3 0.4
Age at last live birth 1.1 1.5 3.8 -1.4 0.3 -1.4 0.9 0.6 -1.7 0.8 -2.0
Family relationship satisfaction 0.9 1.1 3.1 1.3 -0.7 0.3 0.2 -1.3 1.4 -0.4 1.8
Leg pain on walking 1.3 1.6 4.6 1.0 0.0 0.5 1.9 2.1 0.6 -1.6 0.7
Qualifications: NVQ or HND or HNC or equivalent 1.6 1.9 4.5 -0.1 -1.0 1.9 -2.1 -2.1 0.3 1.2 0.3
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.4 0.6 -1.2 0.6 0.0 0.3 0.6 -0.8 0.4
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.0 0.6 0.5 -0.7 0.1 0.9 1.0 0.5 0.8
Medication: Aspirin 1.0 1.3 2.1 -1.4 -0.6 -1.0 -1.3 -0.1 -1.3 1.5 -1.3
Supplements: Vitamin C 1.1 1.4 2.6 -1.5 0.9 -1.3 -0.0 0.4 -1.4 1.1 -1.6
Knee pain experienced in last month 0.9 1.4 2.6 1.4 0.9 1.6 -1.1 0.9 1.2 -0.4 1.4
Hypertension (Self-reported) 0.3 0.7 2.1 0.8 -0.9 -0.0 1.4 1.1 0.7 -0.5 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.0 2.4 7.3 1.6 0.1 0.6 1.7 1.8 1.1 -2.7 1.3
Illnesses of father: Heart disease 0.4 0.5 1.4 -0.9 0.1 0.7 0.2 0.5 -1.2 -0.4 -0.9
Illnesses of siblings: Diabetes 1.6 1.9 3.6 1.7 0.5 1.8 -1.1 -0.3 1.9 -1.0 1.7
Smoking status: Previous 0.2 0.3 0.9 0.2 0.6 0.7 -0.6 -1.0 0.6 0.2 0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.0 -0.6 -0.2 1.4 1.3 0.8 -1.0 0.1 -1.1
Whole body fat-free mass 0.6 3.6 13.9 0.9 1.2 -0.4 3.0 3.7 -0.1 -1.8 0.6
Leg fat-free mass (right) 0.6 3.5 10.6 1.2 1.3 -0.8 2.8 3.3 0.4 -2.0 1.1
Arm fat percentage (left) 0.2 0.8 3.1 -0.7 0.4 -1.1 -1.0 -1.8 -0.2 0.8 0.1
Average weekly red wine intake 2.1 3.1 12.4 -1.3 -3.5 -0.8 -1.3 -2.0 -0.9 1.4 -1.3
Handedness (chirality/laterality): Left-handed 0.7 0.8 4.1 -0.5 -2.0 -0.5 -0.4 -0.6 -0.6 0.9 -0.5
Mood swings 0.8 1.4 3.3 -0.8 0.0 1.1 0.7 1.8 -1.8 -0.1 -1.4
Loneliness, isolation 0.2 0.3 1.5 -0.3 -1.2 0.1 -0.7 -0.1 -0.6 -0.1 -0.2
Long-standing illness, disability or infirmity 1.2 1.9 5.7 1.1 -0.0 -0.8 1.9 1.8 0.6 -2.4 0.7
Ever had bowel cancer screening 0.6 0.7 3.5 0.3 1.9 0.8 0.8 0.8 0.0 -0.3 0.0
Diabetes diagnosed by doctor 0.6 1.0 2.3 1.4 -0.3 0.8 0.0 0.0 1.4 -1.0 1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.1 0.5 -0.1 1.0 0.9 0.2 0.4 -0.6 0.5
Friendships satisfaction 0.9 1.1 2.6 1.2 -0.2 0.7 0.6 -0.6 1.2 -1.3 1.6
Qualifications: nursing, teaching 0.3 0.5 1.5 0.5 1.2 0.5 -0.9 0.2 0.7 -0.5 0.6
Commuting to job workplace: Walk 0.4 0.4 0.8 -0.6 0.4 -0.9 -0.3 -0.8 -0.5 0.9 -0.4
Eye problems/disorders: Cataract 1.6 1.8 10.3 0.7 -3.2 0.4 -0.8 -1.1 0.8 0.2 1.0
Mouth/teeth dental problems: Mouth ulcers 1.2 1.8 5.8 -1.1 0.8 -2.4 1.2 1.5 -1.4 -0.2 -1.2
Medication for cholesterol 0.7 1.0 3.7 0.1 -0.4 -0.4 1.3 1.9 -0.3 -1.5 -0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.5 0.0 0.2 -0.0 -0.7 -0.4 -0.1 -0.4 -0.4
Back pain experienced in last month 0.1 0.2 0.5 0.5 0.0 0.4 -0.7 -0.2 0.4 -0.5 0.3
Mineral and other dietary supplements 0.5 0.6 1.5 0.7 -0.9 0.8 0.6 1.2 0.5 -0.9 0.3
Breast cancer (self-reported) 2.2 2.6 3.9 -2.0 -0.6 -1.0 -1.9 -1.4 -1.7 1.9 -1.8
Asthma (self-reported) 0.1 0.3 1.4 -0.3 0.4 0.1 -1.2 0.2 -0.4 0.2 -0.6
Osteoporosis (self-reported) 0.8 1.0 2.8 1.0 1.1 0.3 1.0 0.7 0.9 -1.7 0.8
Osteoarthritis (self-reported) 0.1 0.2 0.9 -0.2 -0.1 0.3 -0.9 -0.3 -0.6 -0.0 -0.2
Medication: Aspirin 0.9 1.1 1.7 -1.2 -0.9 -1.3 -0.7 0.1 -1.2 1.1 -1.3
Medication: Gliclazide 0.3 0.3 1.1 0.5 -0.4 0.1 0.6 0.7 -0.1 -1.0 0.2
Illnesses of father: None of the above (group 1) 0.9 1.1 3.5 -0.2 1.9 -0.4 -1.1 -1.2 0.2 1.7 0.2
Smoking status: Current 1.5 2.3 4.8 2.1 -0.1 2.2 -0.4 0.8 1.8 -1.2 1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 2.4 0.0 0.9 1.5 0.4 -0.0 -0.1 -0.7 -0.1
Whole body water mass 0.6 3.7 14.3 0.8 1.2 -0.4 3.0 3.8 -0.1 -1.8 0.6
Leg predicted mass (right) 0.7 3.5 10.8 1.2 1.3 -0.9 2.8 3.3 0.4 -2.0 1.1
Arm fat mass (left) 0.1 0.2 0.6 -0.4 0.8 -0.8 -0.1 -0.4 -0.3 0.2 0.1
Number of self-reported non-cancer illnesses 0.2 0.4 0.9 0.8 -0.7 0.0 -0.6 -0.1 0.8 -0.4 0.9
Average weekly champagne plus white wine intake 2.2 3.0 6.3 -1.6 -0.5 -2.4 -2.0 -2.5 -1.4 1.3 -1.3
Miserableness 0.6 1.0 5.7 0.1 0.2 0.6 0.5 2.4 -0.8 -1.0 -0.3
Guilty feelings 0.8 1.2 5.8 0.6 0.5 0.3 1.5 2.4 -0.2 -0.9 0.1
Wears glasses or contact lenses 0.2 0.2 1.1 -0.3 0.1 -0.4 0.7 0.2 0.3 1.0 0.1
Ever taken oral contraceptive pill 4.2 4.7 9.9 2.8 -0.1 1.5 1.5 0.7 2.8 -2.6 3.1
Hearing aid user 0.7 0.8 1.8 -1.2 -0.4 -0.8 0.2 -0.2 -1.4 0.6 -1.3
Mother’s age at death 0.3 0.4 1.0 -0.3 0.7 0.1 1.0 0.4 -0.9 -0.5 -0.6
Financial situation satisfaction 1.5 1.8 7.1 -0.0 -2.7 0.1 -1.4 -2.2 0.4 0.7 0.4
Tinnitus: Yes, now most or all of the time 2.4 2.8 4.8 2.2 1.4 2.1 0.7 0.8 1.9 -1.9 1.7
Commuting to job workplace: Public transport 0.6 0.7 3.5 -0.3 -0.2 -0.5 0.8 1.9 -0.6 0.3 -0.6
Eye problems/disorders: Glaucoma 0.4 0.4 1.0 -0.5 -0.6 -1.0 -0.5 -0.2 -0.5 1.0 -0.4
Medication: Blood pressure 0.2 0.5 1.3 -0.3 -0.7 0.2 -1.0 -0.5 -0.3 1.2 -0.7
Pain type(s) experienced in last month: Hip pain 0.4 0.6 2.3 0.5 0.5 0.6 -1.5 0.0 0.5 -0.6 0.8
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.9 -0.7 0.4 -0.1 -1.0 -1.4 -0.7 0.9 -0.6
High cholesterol (Self-reported) 0.1 0.2 0.7 -0.3 0.1 -0.5 0.3 0.1 -0.3 0.8 -0.1
Medication: Bendroflumethiazide 0.7 1.0 7.2 -0.3 -2.7 0.1 0.1 -0.9 -0.2 0.1 -0.3
Medication: Paracetamol 0.8 1.2 2.6 -1.1 -0.3 -1.3 0.0 1.3 -1.4 0.7 -1.6
Medication: Lisinopril 0.4 0.6 1.2 0.9 1.1 0.1 1.0 0.4 0.9 -0.3 0.5
Medication: Atorvastatin 0.7 0.9 5.9 -0.1 -2.4 -0.8 0.7 0.2 -0.0 -0.3 0.0
Illnesses of father: High blood pressure 0.3 0.4 2.4 -0.5 -1.5 -0.3 0.1 0.2 -0.5 0.0 -0.5
Alcohol drinker status: Never 0.6 0.7 2.3 0.4 0.9 -0.2 1.0 1.5 -0.1 -1.2 0.2
Ever smoked 0.6 1.1 2.2 1.2 1.3 0.7 -0.3 -0.5 1.5 -0.5 1.4
Basal metabolic rate 0.5 2.8 10.4 0.6 1.4 -0.6 2.6 3.2 -0.3 -1.6 0.4
Leg fat percentage (left) 0.8 3.0 8.4 -1.7 0.6 -0.1 -2.4 -2.9 -1.2 2.1 -0.9
Arm fat-free mass (left) 0.5 2.4 9.9 0.2 1.1 -0.1 2.3 3.1 -0.8 -1.2 -0.0
Number of operations (self-reported) 0.1 0.2 0.3 0.4 -0.3 0.5 -0.0 -0.3 0.5 -0.6 0.4
Average weekly beer plus cider intake 3.2 4.6 15.7 0.6 -0.4 0.5 -3.9 -4.0 1.3 1.3 1.1
Irritability 0.5 0.8 1.7 -0.9 0.8 -0.9 0.0 1.2 -1.3 0.2 -1.0
Risk taking 0.7 1.0 4.6 -0.7 2.1 0.0 0.3 0.6 -0.9 1.0 -0.7
Ever had prostate specific antigen (PSA) test 2.5 2.9 5.4 2.3 0.5 -0.0 1.4 1.4 2.3 -1.9 2.3
Fractured/broken bones in last 5 years 0.4 0.5 1.4 -0.3 1.2 0.3 -1.1 -0.4 -0.4 0.1 -0.8
Age started oral contraceptive pill 1.0 1.2 2.7 -1.4 0.5 -1.2 0.4 0.3 -1.6 1.0 -1.4
Diastolic blood pressure, automated reading 0.7 2.3 4.7 -1.5 -2.2 -1.2 -0.6 -2.0 -1.0 1.8 -1.1
Ever depressed for a whole week 0.7 0.9 1.9 0.8 1.1 -0.1 1.4 0.9 0.5 -1.4 0.8
Unable to work because of sickness or disability 0.3 0.4 2.0 -0.6 0.2 1.4 -0.4 -0.3 -0.8 0.1 -0.5
Commuting to job workplace: Cycle 0.9 1.1 4.3 -0.6 2.1 -0.9 0.3 -1.1 -0.2 1.1 -0.5
Myopia 2.4 3.5 8.2 2.6 -0.5 1.7 0.3 0.3 2.6 -1.6 2.9
Vascular/heart problems diagnosed by doctor 0.3 0.7 1.3 -1.0 1.0 0.1 -0.9 -0.7 -1.1 0.2 -1.0
Cholesterol lowering medication 1.3 2.0 4.3 -1.4 0.2 0.1 -1.9 -1.9 -1.0 2.1 -1.1
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 3.2 0.9 -0.5 1.1 0.1 0.8 0.6 -1.8 0.7
Pain experienced in last month 0.6 1.0 2.3 -1.5 -1.0 -0.9 0.4 -0.6 -1.1 1.0 -1.1
Supplements: Calcium 0.8 0.9 2.2 1.2 1.1 0.5 -0.3 -0.5 1.4 0.1 1.5
Basal cell carcinoma (self-reported) 0.4 0.5 2.5 0.1 -0.7 -0.6 1.6 0.9 0.0 -0.3 0.1
Heart attack/myocardial infarction (self-reported) 0.2 0.2 1.0 -0.1 -0.1 0.7 -1.0 0.2 -0.1 0.0 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.3 0.6 1.1 1.0 0.7 1.1 0.2 -0.7 0.0
Heart disease (siblings) 0.2 0.2 0.4 0.4 0.5 0.3 -0.6 -0.6 -0.0 -0.7 0.3
Alcohol drinker status: Previous 0.2 0.2 0.7 -0.3 -0.6 0.1 0.3 0.8 -0.3 0.2 -0.5
Pack years of smoking 0.8 1.2 2.0 1.2 0.2 1.4 0.7 1.1 0.8 -1.4 1.3
Impedance of whole body 0.5 2.7 8.2 -1.4 -1.6 0.2 -2.1 -2.9 -1.0 1.2 -1.5
Leg fat mass (left) 0.1 0.4 1.2 -0.4 0.9 0.1 -0.7 -1.1 -0.2 0.4 0.2
Arm predicted mass (left) 0.5 2.7 10.4 0.2 1.3 -0.3 2.6 3.2 -0.8 -1.3 -0.0