Best TWAS P=2.09e-11 · Best GWAS P=1.15e-14 conditioned to 6.82e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CLEC5A | 0.06 | 0.03 | enet | 15 | 0.04 | 1.1e-05 | -5.1 | 5.5 | 4.5e-08 | -0.60 | 0.78 | 0.21 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | TAS2R5 | 0.10 | 0.12 | enet | 17 | 0.14 | 6.8e-17 | -4.8 | 5.2 | 1.9e-07 | -0.54 | 1.00 | 0.00 | FALSE |
3 | GTEx | Adipose Visceral Omentum | TAS2R4 | 0.09 | 0.07 | lasso | 1 | 0.07 | 2.1e-04 | 5.1 | -5.1 | 3.0e-07 | 0.46 | 0.46 | 0.18 | FALSE |
4 | GTEx | Brain Cortex | WEE2-AS1 | 0.36 | 0.36 | enet | 37 | 0.26 | 8.2e-08 | -4.8 | -5.1 | 2.7e-07 | 0.49 | 1.00 | 0.00 | FALSE |
5 | GTEx | Colon Sigmoid | WEE2-AS1 | 0.26 | 0.14 | enet | 16 | 0.16 | 2.3e-06 | -4.6 | -5.8 | 5.8e-09 | 0.63 | 0.65 | 0.34 | FALSE |
6 | GTEx | Esophagus Gastroesophageal Junction | TAS2R4 | 0.21 | 0.05 | enet | 26 | 0.03 | 2.4e-02 | -4.6 | -5.6 | 1.9e-08 | 0.53 | 0.09 | 0.80 | FALSE |
7 | GTEx | Spleen | TAS2R6 | 0.40 | 0.12 | enet | 35 | 0.10 | 2.0e-03 | -4.6 | 5.3 | 1.1e-07 | -0.54 | 0.35 | 0.40 | FALSE |
8 | GTEx | Thyroid | TAS2R6 | 0.08 | 0.06 | lasso | 2 | 0.05 | 1.5e-04 | -5.0 | 5.4 | 8.4e-08 | -0.48 | 0.87 | 0.08 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MGAM | 0.02 | 0.02 | blup | 5 | 0.02 | 5.8e-03 | -7.5 | 6.7 | 2.1e-11 | -0.78 | 0.00 | 0.83 | TRUE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TAS2R5 | 0.04 | 0.01 | enet | 8 | 0.02 | 4.7e-03 | -4.8 | 5.2 | 1.6e-07 | -0.51 | 0.02 | 0.80 | FALSE |
11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | TAS2R5 | 0.06 | 0.05 | blup | 41 | 0.05 | 1.4e-04 | -4.6 | 5.1 | 2.9e-07 | -0.53 | 0.02 | 0.91 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | PRSS37 | 0.06 | 0.06 | enet | 7 | 0.05 | 1.0e-05 | -5.1 | 5.2 | 2.4e-07 | -0.49 | 0.01 | 0.99 | FALSE |