TWAS hub - MGAM

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1100	0.0280	2.2e-16	0.173	0.149	0.166	0.163	0.175	1.4e-20	9.0e-18	1.1e-19	2.0e-19	8.3e-21
2	ROSMAP	Brain Pre-frontal Cortex	0.0553	0.0185	7.3e-08	0.076	0.059	0.053	0.051	0.067	5.6e-10	4.6e-08	2.1e-07	3.4e-07	5.3e-09
3	TCGA	Brain Lower Grade Glioma	0.0240	0.0155	3.7e-03	0.021	0.016	0.014	NA	0.013	1.9e-03	5.8e-03	7.8e-03	NA	9.9e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Average weekly red wine intake	20.5	30.2	44.9	4.9	4.7	6.7
Alcohol intake frequency.	6.7	15.6	30.8	-2.8	-2.9	-5.5
Alcohol usually taken with meals	6.0	9.7	15.9	2.5	2.6	4.0
Qualifications: A levels/AS levels or equivalent	5.8	12.9	13.6	3.5	3.7	3.6
Medication: Omeprazole (e.g. Zanprol)	4.4	5.3	7.2	2.7	2.6	1.3
Depression (self-reported)	4.2	5.0	6.8	2.1	2.0	2.6
Irritability	4.2	7.1	9.2	2.5	2.4	3.0
Qualifications: O levels/GCSEs or equivalent	3.8	6.0	6.2	2.5	2.4	2.5
Mouth/teeth dental problems: Mouth ulcers	3.7	5.8	8.2	2.8	2.9	1.1
Reason for reducing amount of alcohol drunk: Health precaution	3.5	4.1	5.7	1.8	1.7	2.4
Taking other prescription medications	3.4	5.2	7.9	2.2	1.7	2.8
Average weekly beer plus cider intake	3.4	4.9	5.7	-2.1	-2.1	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	3.2	4.1	4.6	2.0	2.1	2.0
Medication: Omeprazole	3.1	3.7	5.0	2.2	2.1	1.3
Coronary Artery Disease (CAD)	3.0	3.6	5.7	-2.4	-2.3	0.0
Lung cancer (father)	3.0	3.5	6.3	-1.3	-1.5	-2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.8	3.4	4.0	1.7	2.0	-1.8
Wears glasses or contact lenses	2.8	3.2	3.9	2.0	1.9	1.5
Ever taken oral contraceptive pill	2.6	2.9	4.3	-2.1	-2.0	-0.6
Emphysema/chronic bronchitis	2.5	2.8	3.4	-1.8	-1.8	-1.3
Average weekly spirits intake	2.4	2.9	3.3	1.8	1.5	1.8
Other serious medical condition/disability diagnosed by doctor	2.4	3.1	4.4	2.1	1.7	1.3
Leg pain on walking	2.4	3.0	7.7	-1.0	-0.7	-2.8
Qualifications: None of the above	2.3	4.9	8.8	-1.8	-1.6	-3.0
Alcohol intake versus 10 years previously	2.3	3.5	8.9	-0.7	-1.0	-3.0
Alcohol drinker status: Never	2.3	2.7	3.9	-1.6	-1.3	-2.0
Alzheimer’s Disease (including proxy)	2.2	3.2	4.9	2.1	2.2	0.2
Hearing difficulty/problems: Yes	2.1	3.2	3.6	1.9	1.9	1.5
Tinnitus: Yes, now most or all of the time	2.1	2.5	4.2	1.7	2.0	0.5
Ever used hormone-replacement therapy (HRT)	2.0	2.6	4.3	-1.4	-1.3	-2.1
Length of working week for main job	2.0	2.2	2.6	1.2	1.6	-1.6
Verbal and Numeric Reasoning (VNR)	1.9	4.5	5.5	2.0	2.0	2.4
Multivitamins +/- minerals	1.9	2.4	3.2	-1.8	-1.7	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	5.0	0.7	0.9	2.2
Eye problems/disorders: Glaucoma	1.8	2.2	3.2	1.4	1.8	1.1
Commuting to job workplace: Cycle	1.8	2.2	3.4	1.8	1.8	-0.3
Serious illness, injury or assault to yourself	1.7	2.1	3.0	1.7	1.6	0.7
Mouth/teeth dental problems	1.7	2.6	4.1	-2.0	-1.7	-0.9
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	2.3	-1.5	-1.5	-1.4
Medication: Simvastatin	1.6	2.3	2.6	1.6	1.5	1.5
Number of full brothers	1.5	1.9	4.4	-0.7	-0.8	-2.1
Overall health rating	1.5	3.1	5.3	-1.4	-1.5	-2.3
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	3.1	-1.4	-1.8	-0.8
Handedness (chirality/laterality): Left-handed	1.5	1.8	2.5	-1.6	-1.4	-0.9
Prostate Cancer	1.4	1.9	3.5	-1.4	-1.9	-0.5
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.3	-1.5	-1.4	-0.3
Fluid intelligence score	1.4	3.0	3.8	1.6	1.6	2.0
Blood clot in the leg (DVT)	1.4	1.8	2.2	1.5	1.3	1.2
Medication: Allopurinol	1.4	1.8	2.1	1.4	1.2	1.4
Illnesses of father: None of the above (group 1)	1.4	1.7	2.6	-1.2	-1.1	-1.6
Cholesterol lowering medication	1.4	2.1	2.5	1.4	1.6	1.3
Ulcerative Colitis (UC)	1.3	2.5	3.3	1.8	1.6	1.2
Mean Putamen Volume	1.3	1.5	2.2	-1.4	-1.5	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	4.9	0.9	0.7	2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	2.2	1.4	1.5	1.4
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	3.6	1.9	1.8	0.7
Commuting to job workplace: Walk	1.3	1.4	1.5	1.2	1.2	1.2
Heart attack/myocardial infarction (self-reported)	1.3	1.6	2.2	-1.3	-1.5	-1.1
Irritable Bowel Disease (IBD)	1.2	2.9	3.7	1.8	1.3	1.9
Age at First Birth	1.2	1.8	2.1	1.5	1.4	1.2
Respiratory disease	1.2	2.8	4.3	2.1	2.0	-0.2
Heart attack	1.2	1.5	2.1	-1.2	-1.5	-0.9
Birth weight of first child	1.2	2.2	2.3	1.5	1.4	1.5
Neck or shoulder pain in last month	1.2	1.7	2.6	1.6	1.4	0.7
Primary Biliary Cirrhosis	1.1	1.6	2.5	-1.6	-1.5	0.0
Medication: Co-codamol	1.1	1.2	1.5	1.2	1.2	0.9
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.1	1.5	1.3	-0.3
Shortness of breath walking on level ground	1.1	1.3	2.5	-0.9	-0.8	-1.6
Financial situation satisfaction	1.1	1.4	2.3	1.4	1.5	0.0
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	1.8	1.3	1.1	1.1
Alzheimer’s Disease (in father)	1.0	1.1	1.8	1.2	1.3	0.3
Rheumatoid Arthritis	1.0	1.4	2.2	-1.4	-1.5	0.0
Angina	1.0	1.3	2.9	-0.6	-0.8	1.7
Medication: Atenolol	1.0	1.2	1.9	-1.4	-1.3	-0.2
Medication: Ramipril	1.0	1.3	1.7	-1.3	-1.3	-0.8
Illnesses of mother	1.0	1.2	1.4	-1.2	-1.1	-0.9
Medication: Paracetamol	1.0	1.6	2.5	1.6	1.5	-0.0
Medication: Amlodipine	1.0	1.4	1.9	-1.4	-1.2	-0.8
Wheeze or whistling in the chest in last year	1.0	1.7	4.5	-0.4	-0.7	-2.1
Number of self-reported non-cancer illnesses	1.0	1.7	2.2	1.3	1.1	1.5
Medication: Paracetamol	1.0	1.6	2.6	1.6	1.4	0.0
Intelligence (Savage-Jansen 2018)	0.9	2.8	5.0	1.4	1.2	2.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	1.8	0.7	0.8	1.4
Number of incorrect matches in round	0.9	1.6	2.5	1.4	1.6	-0.6
Happiness	0.9	1.1	1.4	1.2	1.2	0.7
Pulse wave Arterial Stiffness index	0.9	1.1	3.0	-0.4	-0.2	-1.7
Exposure to tobacco smoke outside home	0.9	1.2	1.8	1.3	1.3	-0.4
Mean time to correctly identify matches	0.9	1.7	2.1	1.4	1.2	1.2
Knee pain experienced in last month	0.9	1.3	3.6	-0.5	-0.4	-1.9
Major Depression (MDD)	0.8	1.0	1.4	-1.2	-1.2	0.4
Reaction Time	0.8	1.4	2.0	1.4	1.2	1.0
Crohns Disease (2012)	0.8	1.4	2.6	0.8	0.9	1.6
Hypothyroidism (self reported)	0.8	1.9	2.9	1.6	1.7	0.5
Diabetes (mother)	0.8	1.0	1.6	-1.2	-1.3	0.3
Had menopause	0.8	1.0	1.3	1.1	1.1	0.7
Pain all over the body in last month	0.8	0.8	2.0	-0.4	-0.5	-1.4
Pulse wave reflection index	0.8	0.9	2.6	-0.4	-0.2	-1.6
Gout (self-reported)	0.8	1.1	1.4	1.1	0.9	1.2
Pulse wave peak to peak time	0.8	1.0	2.9	0.2	0.0	1.7
Medication for pain relief, constipation, heartburn	0.8	1.4	2.1	-1.5	-1.4	0.2
Angina (self-reported)	0.8	1.0	2.3	-0.5	-0.7	1.5
Mineral and other dietary supplements	0.8	1.0	1.7	1.1	1.3	-0.0
Breast cancer (self-reported)	0.8	1.0	2.3	0.4	0.7	1.5
Vascular/heart problems diagnosed by doctor	0.8	2.1	2.9	1.7	1.7	0.8
Pack years of smoking	0.8	1.2	1.8	1.3	1.3	0.2
Neuroticism	0.7	1.6	1.8	1.3	1.1	1.3
Diabetes (father)	0.7	0.9	1.3	1.2	1.1	0.3
Loud music exposure frequency	0.7	0.7	2.1	0.2	-0.0	-1.4
Qualifications: College or University degree	0.7	2.3	2.6	1.4	1.6	1.6
Medication: Blood pressure	0.7	1.1	1.7	-1.3	-1.1	-0.7
Supplements: Vitamin C	0.7	0.9	2.6	-0.0	-0.0	1.6
Hypertension (Self-reported)	0.7	2.0	2.1	-1.5	-1.4	-1.4
Eye problems/disorders: Cataract	0.7	0.8	1.4	1.0	1.2	-0.0
Medication: Blood pressure	0.7	1.2	1.6	-1.2	-1.1	-1.0
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.1	-0.9	-1.0	-0.9
Medication: Atorvastatin	0.7	0.8	1.4	-1.0	-1.2	-0.1
Age started oral contraceptive pill	0.7	0.9	1.8	0.5	0.7	1.4
Crohns Disease (2017)	0.6	1.4	3.2	0.8	0.6	1.8
Body Mass Index (BMI) (2010)	0.6	0.8	1.2	1.1	1.0	-0.5
Ulcerative Colitis	0.6	0.9	1.4	1.2	1.0	0.4
Tanning	0.6	7.7	8.5	-2.9	-2.9	-2.5
Qualifications: CSEs or equivalent	0.6	0.8	2.4	0.0	-0.0	-1.6
High blood pressure	0.6	1.7	1.7	-1.3	-1.3	-1.3
Stomach or abdominal pain in last month	0.6	0.8	1.0	0.9	1.0	-0.7
Supplements: Glucosamine	0.6	0.8	1.3	-0.9	-1.1	0.5
Financial difficulties in last 2 years	0.6	0.8	0.8	0.8	0.9	0.9
Diabetes (self-reported)	0.6	0.9	2.2	0.5	0.4	1.5
Number of children fathered	0.6	0.7	1.5	-0.5	-0.4	-1.2
Age at first live birth	0.6	1.1	1.4	1.2	1.0	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.2	1.1	0.8	-0.4
Osteoarthritis (self-reported)	0.6	0.8	1.4	1.0	1.2	-0.2
Hearing aid user	0.6	0.6	0.9	0.6	0.8	1.0
Unable to work because of sickness or disability	0.6	0.8	1.2	1.1	1.1	-0.4
Bipolar Disorder (2011)	0.5	0.5	0.7	-0.8	-0.9	0.0
Blood White Count	0.5	4.1	5.8	-1.9	-1.6	-2.4
Allergy or Eczema	0.5	1.3	1.4	1.1	1.1	1.2
Lung FVC	0.5	2.7	4.2	1.8	2.0	0.9
Time employed in main current job	0.5	0.6	1.2	-0.6	-0.5	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.8	0.7	0.5	1.3
Pulse rate	0.5	0.8	1.4	1.0	1.2	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.1	-1.0	-0.8	-0.4
Headache pain in last month	0.5	0.9	1.3	1.1	1.2	-0.3
High blood pressure (siblings)	0.5	0.7	0.7	-0.9	-0.8	-0.8
Health satisfaction	0.5	0.6	1.0	-1.0	-0.6	-0.6
Medication: Ibuprofen	0.5	0.5	1.6	0.0	0.1	-1.3
Ever had bowel cancer screening	0.5	0.5	1.4	0.3	0.4	1.2
Medication: Gliclazide	0.5	0.5	1.2	-0.4	-0.4	1.1
Smoking status: Current	0.5	0.8	1.1	1.0	1.0	-0.4
Miserableness	0.5	0.8	1.2	-1.0	-1.1	-0.4
Fractured/broken bones in last 5 years	0.5	0.6	0.9	0.8	0.9	-0.6
Supplements: Calcium	0.5	0.6	0.9	-0.6	-0.7	0.9
Heart disease (siblings)	0.5	0.6	1.2	-0.4	-0.7	1.1
Schizophrenia (2018)	0.4	0.9	1.9	-0.6	-0.6	-1.4
Fasting Glucose	0.4	0.5	0.7	0.8	0.7	0.5
Neuroticism (2016)	0.4	0.6	1.0	1.0	0.9	-0.2
Triglycerides	0.4	0.6	1.8	-0.2	0.0	-1.3
Vitamin and mineral supplements	0.4	0.6	0.8	0.9	0.8	-0.6
Townsend deprivation index at recruitment	0.4	0.6	1.7	-0.2	-0.1	-1.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	0.9	1.0	0.8	0.9
Medication: Levothyroxine sodium	0.4	0.7	1.0	1.0	1.0	-0.2
Hearing difficulty/problems with background noise	0.4	0.6	1.0	0.9	1.0	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.5	-0.6	-0.5	-1.6
Illnesses of siblings	0.4	0.5	1.5	-0.3	-0.1	-1.2
Falls in the last year	0.4	0.5	0.9	0.5	0.5	-1.0
Mouth/teeth dental problems: Dentures	0.4	0.7	1.1	1.1	0.9	-0.1
Eye problems/disorders: None of the above	0.4	0.5	1.0	-0.7	-1.0	-0.2
Chest pain or discomfort	0.4	0.5	1.6	-0.1	-0.1	-1.3
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.7	-0.8	-0.5	-0.7
Long-standing illness, disability or infirmity	0.4	0.6	0.9	0.8	0.6	0.9
Qualifications: nursing, teaching	0.4	0.5	0.8	0.9	0.8	0.5
Average weekly champagne plus white wine intake	0.4	0.5	1.1	-0.6	-0.2	-1.1
High cholesterol (Self-reported)	0.4	0.7	1.6	0.5	0.5	1.3
Myopia	0.4	0.5	1.0	1.0	0.8	0.2
Depression (Nagel 2018)	0.3	0.5	0.7	-0.9	-0.8	-0.2
Neuroticism (Nagel 2018)	0.3	0.7	0.8	0.8	0.8	0.9
Alzheimer’s Disease (in mother)	0.3	0.4	0.5	0.7	0.7	-0.4
Schizophrenia (2014)	0.3	0.6	1.0	-1.0	-1.0	0.0
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.1	-0.0	-0.1	-1.0
Blood Eosinophil Count	0.3	2.3	2.7	-1.6	-1.4	-1.5
Heel T-Score	0.3	2.7	7.7	-0.5	-0.3	-2.8
Medication for hormone replacement therapy	0.3	0.3	0.5	0.1	0.7	-0.6
Supplements: Zinc	0.3	0.3	0.8	0.2	0.4	0.9
Severe depression (siblings)	0.3	0.3	0.9	-0.2	0.0	-0.9
Pack years adult smoking proportion	0.3	0.5	0.9	0.8	0.9	-0.1
Current tobacco smoking	0.3	0.5	0.6	0.7	0.6	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	0.7	-0.8	-0.8	0.2
Age when periods started (menarche)	0.3	0.6	1.5	-0.6	-0.3	-1.2
Trunk fat-free mass	0.3	1.9	2.9	-1.7	-1.6	-0.4
Number of live births	0.3	0.4	0.7	-0.8	-0.5	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.8	-0.3	-0.2	-0.9
Impedance of arm (left)	0.3	1.3	1.8	1.4	1.1	0.8
Trunk predicted mass	0.3	1.9	2.9	-1.7	-1.6	-0.3
Breastfed as a baby	0.3	0.4	0.7	0.8	0.7	-0.2
Arm fat-free mass (right)	0.3	1.5	2.2	-1.5	-1.5	-0.1
Medication: Seretide 50 evohaler	0.3	0.4	0.7	-0.4	-0.4	0.9
Arm predicted mass (right)	0.3	1.4	2.0	-1.4	-1.4	0.0
Osteoporosis (self-reported)	0.3	0.4	0.4	0.6	0.6	-0.6
Medication: Aspirin	0.3	0.3	0.4	-0.5	-0.6	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	1.2	0.4	0.5	1.1
Guilty feelings	0.3	0.4	0.6	-0.6	-0.4	0.8
Commuting to job workplace: Public transport	0.3	0.3	0.6	-0.6	-0.8	0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.5	-0.5	-0.7	-0.7
Medication: Lisinopril	0.3	0.4	1.0	-0.2	-0.4	1.0
Basal metabolic rate	0.3	1.4	2.1	-1.5	-1.4	-0.2
Arm fat-free mass (left)	0.3	1.6	2.4	-1.6	-1.5	-0.1
Number of operations (self-reported)	0.3	0.5	1.3	-0.5	-0.1	-1.1
Risk taking	0.3	0.4	0.8	0.5	0.3	0.9
Alcohol drinker status: Previous	0.3	0.3	0.4	-0.5	-0.6	-0.5
Impedance of whole body	0.3	1.4	1.7	1.3	1.0	1.2
Arm predicted mass (left)	0.3	1.6	2.4	-1.6	-1.6	-0.0
Worry (Nagel 2018)	0.2	0.4	0.5	0.7	0.7	0.5
Ovarian Cancer	0.2	0.2	0.6	0.2	0.4	-0.8
Lupus	0.2	0.3	0.5	-0.3	-0.4	-0.7
Cardiovascular Disease	0.2	0.7	0.9	-0.9	-0.9	-0.7
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.0	0.1	0.1	1.0
Lung FEV1/FVC ratio	0.2	0.9	1.9	0.7	0.5	1.4
Number of treatments/medications taken	0.2	0.3	0.5	0.7	0.5	0.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	0.5	0.5	-0.4
Average weekly fortified wine intake	0.2	0.2	0.5	-0.4	-0.2	0.7
Maternal smoking around birth	0.2	0.3	0.8	-0.0	-0.0	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.4	0.1	0.2	-1.2
Leg predicted mass (left)	0.2	0.9	1.4	-1.2	-1.1	-0.2
Nervous feelings	0.2	0.4	0.5	0.6	0.5	0.7
Had other major operations	0.2	0.3	0.3	0.5	0.5	-0.6
Forced vital capacity (FVC)	0.2	0.8	2.0	-0.5	-0.2	-1.4
Weight	0.2	1.1	1.7	-1.3	-1.3	-0.0
Impedance of arm (right)	0.2	1.1	1.4	1.2	1.0	1.0
Father’s age at death	0.2	0.3	0.6	-0.4	-0.7	0.3
Asthma	0.2	0.3	0.9	0.2	0.1	-1.0
Medication: Cholesterol lowering	0.2	0.3	0.4	0.6	0.4	0.6
Arm fat mass (right)	0.2	0.8	1.3	-1.1	-1.1	0.3
Peak expiratory flow (PEF)	0.2	0.6	1.6	-0.3	-0.1	-1.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.5	0.6	0.7	-0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.2	0.5	0.4	-0.4
Forced vital capacity (FVC), Best measure	0.2	0.6	1.3	-0.7	-0.4	-1.1
Whole body fat mass	0.2	0.7	1.0	-0.8	-1.0	0.7
Leg fat mass (right)	0.2	0.7	0.9	-0.9	-1.0	0.7
Number of full sisters	0.2	0.2	0.5	-0.4	-0.1	-0.7
Had major operations	0.2	0.3	0.4	-0.6	-0.5	-0.4
Family relationship satisfaction	0.2	0.2	0.3	-0.4	-0.5	-0.5
Illnesses of siblings: Diabetes	0.2	0.3	0.7	0.4	0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.6	-0.7	-0.5	-0.4
Whole body fat-free mass	0.2	1.4	2.1	-1.4	-1.4	-0.4
Leg fat-free mass (right)	0.2	0.8	1.2	-1.1	-1.0	-0.5
Diabetes diagnosed by doctor	0.2	0.3	0.8	-0.2	-0.2	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	0.6	0.5	-0.0
Asthma (self-reported)	0.2	0.4	1.1	0.3	0.2	-1.1
Whole body water mass	0.2	1.4	2.1	-1.4	-1.4	-0.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	-0.2	-0.4	0.6
Diastolic blood pressure, automated reading	0.2	0.6	1.0	-0.7	-0.6	-1.0
Ever depressed for a whole week	0.2	0.2	0.4	-0.5	-0.6	0.1
Pain experienced in last month	0.2	0.3	0.8	0.0	0.0	0.9
Leg fat mass (left)	0.2	0.8	1.1	-1.0	-1.0	0.5
Bipolar Disorder (2018)	0.1	0.1	0.2	-0.3	-0.4	0.0
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	-0.7	-0.7	0.0
Breast Cancer	0.1	0.3	0.8	0.4	0.2	0.9
HbA1C	0.1	0.1	0.1	-0.4	-0.3	-0.1
HDL Cholesterol	0.1	0.2	0.2	0.3	0.5	0.4
LDL Cholesterol	0.1	0.2	0.4	0.6	0.5	-0.2
Blood Red Count	0.1	0.9	1.4	-1.2	-1.1	-0.2
BMI	0.1	0.5	0.9	-1.0	-0.6	-0.1
Sensitivity / hurt feelings	0.1	0.1	0.3	0.3	0.1	-0.5
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.1	-0.3	-0.3	0.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	0.2	0.3	0.6
Medication: Metformin	0.1	0.2	0.4	-0.2	-0.1	0.7
Impedance of leg (right)	0.1	0.7	0.9	0.8	0.6	1.0
Leg fat-free mass (left)	0.1	0.8	1.2	-1.1	-1.0	-0.1
Trunk fat percentage	0.1	0.5	1.5	0.2	-0.1	1.2
Hand grip strength (right)	0.1	0.2	0.2	0.5	0.5	0.2
Relative age voice broke	0.1	0.1	0.1	0.1	0.4	0.3
Sitting height	0.1	0.6	1.1	-0.9	-1.0	0.2
Body mass index (BMI)	0.1	0.5	0.7	-0.9	-0.9	0.1
Impedance of leg (left)	0.1	0.5	0.6	0.8	0.6	0.7
Trunk fat mass	0.1	0.5	0.6	-0.6	-0.7	0.7
Waist circumference	0.1	0.5	0.8	-0.8	-0.9	0.4
Allergy	0.1	0.2	0.5	-0.4	-0.1	-0.7
Arm fat percentage (right)	0.1	0.3	0.7	-0.2	-0.4	0.9
Hip circumference	0.1	0.4	0.7	-0.5	-0.5	0.8
Worrier / anxious feelings	0.1	0.2	0.4	-0.1	-0.3	-0.6
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.4	-0.2	0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.3	-0.1	0.1	-1.2
Medication: Lansoprazole	0.1	0.1	0.1	-0.3	0.0	-0.3
Prospective memory result	0.1	0.1	0.1	-0.2	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.1	-0.4	-0.1	-1.1
Standing height	0.1	1.2	1.9	-1.2	-1.4	-0.3
Exposure to tobacco smoke at home	0.1	0.1	0.1	0.2	0.1	0.4
Tense / ‘highly strung’	0.1	0.1	0.2	-0.4	-0.5	-0.1
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	-0.3	-0.7	-0.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.4	-0.1	-0.2	-0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.1	0.3	0.1	0.4
Glaucoma (self-reported)	0.1	0.1	0.2	-0.3	0.1	-0.4
Birth weight	0.1	0.1	0.2	-0.1	-0.4	0.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.4	-0.1	-0.1	0.6
Body fat percentage	0.1	0.4	1.2	-0.1	-0.3	1.1
Leg fat percentage (right)	0.1	0.3	0.7	-0.3	-0.4	0.8
Comparative body size at age 10	0.1	0.2	0.3	-0.5	-0.5	-0.4
Migraine (self-reported)	0.1	0.1	0.2	0.4	0.2	0.5
Heart disease (mother)	0.1	0.1	0.2	0.3	0.5	-0.2
Pulse rate, automated reading	0.1	0.2	0.4	0.2	0.3	0.6
Suffer from ‘nerves’	0.1	0.1	0.3	0.3	0.1	0.5
Medication: Aspirin	0.1	0.2	0.3	-0.3	-0.3	0.6
Arm fat percentage (left)	0.1	0.3	0.8	-0.0	-0.2	0.9
Mood swings	0.1	0.2	0.3	0.5	0.5	0.1
Loneliness, isolation	0.1	0.2	0.2	0.5	0.5	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	-0.5	-0.4	-0.0
Friendships satisfaction	0.1	0.1	0.1	0.3	0.1	-0.4
Medication for cholesterol	0.1	0.1	0.2	0.0	-0.3	-0.5
Back pain experienced in last month	0.1	0.1	0.3	-0.3	-0.5	-0.1
Leg predicted mass (right)	0.1	0.7	1.0	-1.0	-0.9	-0.4
Arm fat mass (left)	0.1	0.4	0.5	-0.6	-0.7	0.7
Medication: Bendroflumethiazide	0.1	0.1	0.2	0.4	0.5	-0.2
Illnesses of father: High blood pressure	0.1	0.2	0.4	0.6	0.3	0.2
Ever smoked	0.1	0.1	0.2	-0.0	-0.2	-0.5
Leg fat percentage (left)	0.1	0.2	0.3	-0.4	-0.5	0.5
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.2	0.4	-0.2
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	0.2	0.3	0.2
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.1	-0.1	0.0
Blood Platelet Count	0.0	0.6	1.4	-0.5	-0.3	-1.2
Height	0.0	0.1	0.3	0.0	-0.0	0.5
Waist Hip Ratio (WHR)	0.0	0.1	0.1	-0.3	-0.3	-0.0
Systolic Blood Pressure	0.0	0.1	0.1	-0.3	-0.3	-0.2
Smoking Status	0.0	0.0	0.0	0.2	0.2	-0.0
Chronotype (morning person)	0.0	0.1	0.1	-0.3	-0.2	-0.1
Hair Pigment	0.0	1.0	2.0	0.5	0.9	1.4
Hand grip strength (left)	0.0	0.1	0.2	0.1	0.2	-0.5
Relative age of first facial hair	0.0	0.1	0.2	-0.0	0.2	-0.5
Systolic blood pressure, automated reading	0.0	0.1	0.2	-0.1	-0.0	-0.5
Fed-up feelings	0.0	0.1	0.1	0.2	0.4	-0.2
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	-0.1	0.0	0.4
High blood pressure (mother)	0.0	0.0	0.1	0.2	0.2	-0.3
Past tobacco smoking	0.0	0.0	0.0	-0.1	-0.1	-0.1
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	-0.2	-0.1	-0.0
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	-0.0	0.0	0.3
Neuroticism score	0.0	0.1	0.1	-0.0	-0.2	0.4
Noisy workplace	0.0	0.0	0.1	0.2	-0.1	0.2
Worry too long after embarrassment	0.0	0.0	0.1	0.3	0.0	0.0
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	-0.2	-0.2	0.2
Comparative height size at age 10	0.0	0.0	0.0	-0.0	-0.2	0.0
Age at last live birth	0.0	0.1	0.2	0.0	0.0	0.4
Illnesses of father: Heart disease	0.0	0.1	0.2	-0.0	-0.1	0.4
Smoking status: Previous	0.0	0.1	0.2	-0.0	-0.1	0.4
Mother’s age at death	0.0	0.0	0.1	0.3	0.1	0.1

Hub : Genes

MGAM

Models

Trait associations