Hub : Traits :

Average weekly red wine intake

77 significantly associated models · 26 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 43899918 45698128 1 1 4.2e-08 6.1e-08 1.0e+00 100 CAMKMT
2 3 70757099 71880670 1 1 2.7e-08 7.1e-09 2.3e-02 84 FOXP1
3 7 140705484 142344964 7 1 2.1e-11 1.1e-14 6.8e-05 73 MGAM
4 10 64195778 65606229 1 1 8.6e-08 3.3e-09 3.1e-03 75 NRBF2
5 11 56666189 58284951 7 2 3.2e-10 2.3e-09 1.0e+00 100 CTNND1 ZDHHC5
6 11 65549606 66963425 3 2 1.4e-08 9.8e-09 1.0e+00 100 CNIH2 DPP3
7 12 123049746 124449223 2 1 1.7e-08 1.5e-06 9.7e-01 100 RILPL2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 2.74 2 0 0.0 0.00 1.0e+00 CNIH2 ZDHHC5
Depression (Nagel 2018) 4.21 2 1 2.2 0.00 1.0e+00 NRBF2 ZDHHC5
Intelligence (Savage-Jansen 2018) 5.01 5 2 4.4 0.99 2.0e-03 CAMKMT FOXP1 NRBF2 RILPL2 ZDHHC5
Neuroticism (Nagel 2018) 2.95 1 1 2.2 0.00 1.0e+00 ZDHHC5
Schizophrenia (2018) 2.49 2 0 0.0 0.00 1.0e+00 FOXP1 ZDHHC5
Schizophrenia vs Biploar Disorder 4.27 1 0 0.0 0.00 1.0e+00 ZDHHC5
Worry (Nagel 2018) 1.35 1 0 0.0 0.00 1.0e+00 ZDHHC5
Major Depression (MDD) 4.65 1 0 0.0 0.00 1.0e+00 ZDHHC5
Verbal and Numeric Reasoning (VNR) 5.14 5 1 2.2 0.98 3.3e-03 CAMKMT FOXP1 NRBF2 RILPL2 ZDHHC5
Breast Cancer 3.52 3 0 0.0 0.00 1.0e+00 CNIH2 DPP3 NRBF2
Age at First Birth 1.72 1 0 0.0 0.00 1.0e+00 NRBF2
HDL Cholesterol 2.82 1 0 0.0 0.00 1.0e+00 NRBF2
Schizophrenia (2014) 2.40 2 0 0.0 0.00 1.0e+00 FOXP1 ZDHHC5
Triglycerides 4.07 1 1 2.2 0.00 1.0e+00 NRBF2
Blood Eosinophil Count 1.16 3 1 2.2 0.00 1.0e+00 CTNND1 RILPL2 ZDHHC5
Blood Platelet Count 13.68 3 3 6.7 0.00 1.0e+00 NRBF2 RILPL2 ZDHHC5
Blood Red Count 1.57 5 1 2.2 -0.69 2.0e-01 CAMKMT DPP3 NRBF2 RILPL2 ZDHHC5
Blood White Count 3.45 2 1 2.2 0.00 1.0e+00 FOXP1 NRBF2
Heel T-Score 2.03 2 2 4.4 0.00 1.0e+00 RILPL2 ZDHHC5
BMI 2.40 4 2 4.4 -0.99 7.2e-03 CAMKMT CNIH2 FOXP1 NRBF2
Height 2.76 5 5 11.1 0.84 7.8e-02 CAMKMT CNIH2 NRBF2 RILPL2 ZDHHC5
Waist Hip Ratio (WHR) 2.37 2 1 2.2 0.00 1.0e+00 NRBF2 RILPL2
Systolic Blood Pressure 2.10 2 1 2.2 0.00 1.0e+00 CTNND1 ZDHHC5
Smoking Status 2.31 1 0 0.0 0.00 1.0e+00 FOXP1
Allergy or Eczema 2.39 1 0 0.0 0.00 1.0e+00 RILPL2
Type 2 Diabetes (T2D) (2018) 2.33 1 0 0.0 0.00 1.0e+00 CAMKMT
Lung FEV1/FVC ratio 2.67 2 2 4.4 0.00 1.0e+00 NRBF2 ZDHHC5
Lung FVC 3.52 5 1 2.2 -0.16 8.0e-01 CNIH2 DPP3 FOXP1 NRBF2 RILPL2
Neuroticism 3.17 2 1 2.2 0.00 1.0e+00 CTNND1 ZDHHC5
Chronotype (morning person) 3.44 3 0 0.0 0.00 1.0e+00 CAMKMT CTNND1 ZDHHC5
Hair Pigment 0.25 2 1 2.2 0.00 1.0e+00 CNIH2 RILPL2
Hand grip strength (left) 1.77 2 0 0.0 0.00 1.0e+00 FOXP1 ZDHHC5
Number of treatments/medications taken 1.16 1 0 0.0 0.00 1.0e+00 FOXP1
Sensitivity / hurt feelings 1.74 1 0 0.0 0.00 1.0e+00 ZDHHC5
Frequency of depressed mood in last 2 weeks 3.30 1 0 0.0 0.00 1.0e+00 ZDHHC5
Relative age of first facial hair 1.12 1 0 0.0 0.00 1.0e+00 NRBF2
Systolic blood pressure, automated reading 1.86 1 0 0.0 0.00 1.0e+00 ZDHHC5
Vitamin and mineral supplements 2.81 1 0 0.0 0.00 1.0e+00 CNIH2
Supplements: Zinc 2.73 1 0 0.0 0.00 1.0e+00 NRBF2
Pack years adult smoking proportion 3.74 1 0 0.0 0.00 1.0e+00 NRBF2
Impedance of leg (right) 0.86 1 0 0.0 0.00 1.0e+00 NRBF2
Leg fat-free mass (left) 1.09 1 1 2.2 0.00 1.0e+00 RILPL2
Trunk fat percentage 2.80 4 2 4.4 -0.98 2.4e-02 CAMKMT CNIH2 FOXP1 ZDHHC5
Hand grip strength (right) 1.83 1 0 0.0 0.00 1.0e+00 FOXP1
Townsend deprivation index at recruitment 2.21 1 0 0.0 0.00 1.0e+00 ZDHHC5
Current tobacco smoking 2.94 1 0 0.0 0.00 1.0e+00 NRBF2
Fed-up feelings 5.08 2 0 0.0 0.00 1.0e+00 CNIH2 ZDHHC5
Frequency of unenthusiasm / disinterest in last 2 weeks 4.52 2 0 0.0 0.00 1.0e+00 NRBF2 ZDHHC5
Age when periods started (menarche) 1.41 1 0 0.0 0.00 1.0e+00 NRBF2
Heel bone mineral density (BMD) T-score, automated (left) 1.08 1 0 0.0 0.00 1.0e+00 RILPL2
High blood pressure 1.20 1 0 0.0 0.00 1.0e+00 NRBF2
Stomach or abdominal pain in last month 1.31 1 0 0.0 0.00 1.0e+00 FOXP1
Sitting height 3.73 3 2 4.4 0.00 1.0e+00 CAMKMT RILPL2 ZDHHC5
Body mass index (BMI) 2.47 3 1 2.2 0.00 1.0e+00 CAMKMT FOXP1 NRBF2
Impedance of leg (left) 0.92 2 0 0.0 0.00 1.0e+00 NRBF2 RILPL2
Leg predicted mass (left) 1.08 1 1 2.2 0.00 1.0e+00 RILPL2
Trunk fat mass 2.24 2 1 2.2 0.00 1.0e+00 CNIH2 FOXP1
Waist circumference 1.94 3 0 0.0 0.00 1.0e+00 CNIH2 FOXP1 NRBF2
Alcohol usually taken with meals 11.20 7 3 6.7 0.99 2.9e-05 CNIH2 CTNND1 FOXP1 MGAM NRBF2 RILPL2 ZDHHC5
Had menopause 1.53 1 0 0.0 0.00 1.0e+00 RILPL2
Forced vital capacity (FVC) 1.91 1 1 2.2 0.00 1.0e+00 FOXP1
Qualifications: None of the above 11.34 5 3 6.7 -0.97 5.7e-03 CAMKMT FOXP1 NRBF2 RILPL2 ZDHHC5
Allergy 2.03 1 0 0.0 0.00 1.0e+00 RILPL2
Fluid intelligence score 6.51 5 1 2.2 0.97 5.8e-03 CAMKMT FOXP1 NRBF2 RILPL2 ZDHHC5
Neuroticism score 2.81 1 1 2.2 0.00 1.0e+00 ZDHHC5
Weight 1.65 3 1 2.2 0.00 1.0e+00 CNIH2 FOXP1 RILPL2
Impedance of arm (right) 2.23 2 1 2.2 0.00 1.0e+00 NRBF2 ZDHHC5
Arm fat percentage (right) 2.68 4 1 2.2 -0.98 1.6e-02 CAMKMT CNIH2 FOXP1 ZDHHC5
Trunk fat-free mass 1.69 2 1 2.2 0.00 1.0e+00 RILPL2 ZDHHC5
Hip circumference 1.40 2 0 0.0 0.00 1.0e+00 CNIH2 RILPL2
Alcohol intake versus 10 years previously 4.33 3 0 0.0 0.00 1.0e+00 CAMKMT FOXP1 RILPL2
Worrier / anxious feelings 1.92 1 1 2.2 0.00 1.0e+00 ZDHHC5
Frequency of tiredness / lethargy in last 2 weeks 4.29 2 1 2.2 0.00 1.0e+00 CTNND1 ZDHHC5
Forced expiratory volume in 1-second (FEV1) 2.07 2 1 2.2 0.00 1.0e+00 FOXP1 ZDHHC5
Qualifications: A levels/AS levels or equivalent 9.24 6 3 6.7 0.96 2.2e-03 CAMKMT CNIH2 FOXP1 MGAM NRBF2 RILPL2
Prospective memory result 3.31 1 0 0.0 0.00 1.0e+00 CAMKMT
Forced expiratory volume in 1-second (FEV1), Best measure 2.08 2 0 0.0 0.00 1.0e+00 FOXP1 ZDHHC5
Impedance of arm (left) 2.04 2 1 2.2 0.00 1.0e+00 NRBF2 ZDHHC5
Arm fat mass (right) 2.22 4 0 0.0 -1.00 5.0e-03 CAMKMT CNIH2 FOXP1 NRBF2
Trunk predicted mass 1.70 2 1 2.2 0.00 1.0e+00 RILPL2 ZDHHC5
Standing height 2.66 5 3 6.7 0.82 8.9e-02 CAMKMT CNIH2 NRBF2 RILPL2 ZDHHC5
Breastfed as a baby 2.15 1 0 0.0 0.00 1.0e+00 RILPL2
Tense / 'highly strung' 1.68 1 0 0.0 0.00 1.0e+00 ZDHHC5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.85 1 0 0.0 0.00 1.0e+00 ZDHHC5
Peak expiratory flow (PEF) 1.66 1 0 0.0 0.00 1.0e+00 ZDHHC5
Qualifications: O levels/GCSEs or equivalent 8.06 4 2 4.4 1.00 2.0e-03 CAMKMT FOXP1 NRBF2 RILPL2
Headache pain in last month 2.04 2 0 0.0 0.00 1.0e+00 FOXP1 ZDHHC5
High blood pressure (siblings) 1.64 1 0 0.0 0.00 1.0e+00 NRBF2
Forced vital capacity (FVC), Best measure 1.79 2 1 2.2 0.00 1.0e+00 CAMKMT FOXP1
Body fat percentage 3.20 4 2 4.4 -0.97 2.9e-02 CAMKMT CNIH2 FOXP1 ZDHHC5
Leg fat percentage (right) 3.75 4 1 2.2 -1.00 1.3e-03 CAMKMT CNIH2 FOXP1 NRBF2
Arm fat-free mass (right) 1.53 3 1 2.2 0.00 1.0e+00 CNIH2 RILPL2 ZDHHC5
Exposure to tobacco smoke outside home 1.86 1 0 0.0 0.00 1.0e+00 NRBF2
Comparative body size at age 10 1.15 1 0 0.0 0.00 1.0e+00 DPP3
Worry too long after embarrassment 3.48 1 1 2.2 0.00 1.0e+00 ZDHHC5
Age at first live birth 3.39 1 0 0.0 0.00 1.0e+00 NRBF2
Qualifications: College or University degree 7.54 7 4 8.9 0.98 1.9e-04 CAMKMT CNIH2 DPP3 FOXP1 NRBF2 RILPL2 ZDHHC5
Whole body fat mass 2.32 2 1 2.2 0.00 1.0e+00 CNIH2 FOXP1
Leg fat mass (right) 2.61 4 1 2.2 -0.99 7.8e-03 CAMKMT CNIH2 FOXP1 NRBF2
Arm predicted mass (right) 1.40 2 1 2.2 0.00 1.0e+00 CNIH2 RILPL2
Pulse rate, automated reading 1.41 1 1 2.2 0.00 1.0e+00 ZDHHC5
Alcohol intake frequency. 7.54 6 2 4.4 -1.00 2.6e-05 CNIH2 CTNND1 FOXP1 MGAM RILPL2 ZDHHC5
Comparative height size at age 10 2.68 2 1 2.2 0.00 1.0e+00 CAMKMT RILPL2
Overall health rating 5.58 4 1 2.2 0.07 9.3e-01 CNIH2 FOXP1 NRBF2 ZDHHC5
Age at last live birth 2.33 1 0 0.0 0.00 1.0e+00 NRBF2
Hypertension (Self-reported) 1.31 1 0 0.0 0.00 1.0e+00 NRBF2
Whole body fat-free mass 1.38 1 1 2.2 0.00 1.0e+00 RILPL2
Leg fat-free mass (right) 1.01 1 1 2.2 0.00 1.0e+00 RILPL2
Arm fat percentage (left) 2.65 4 1 2.2 -0.98 1.5e-02 CAMKMT CNIH2 FOXP1 ZDHHC5
Mood swings 2.04 1 0 0.0 0.00 1.0e+00 CNIH2
Loneliness, isolation 2.50 1 0 0.0 0.00 1.0e+00 ZDHHC5
Long-standing illness, disability or infirmity 2.56 2 0 0.0 0.00 1.0e+00 CNIH2 FOXP1
Qualifications: nursing, teaching 6.17 2 1 2.2 0.00 1.0e+00 RILPL2 ZDHHC5
Mineral and other dietary supplements 4.00 1 0 0.0 0.00 1.0e+00 NRBF2
Smoking status: Current 2.78 1 0 0.0 0.00 1.0e+00 NRBF2
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.10 2 0 0.0 0.00 1.0e+00 FOXP1 NRBF2
Whole body water mass 1.38 1 1 2.2 0.00 1.0e+00 RILPL2
Leg predicted mass (right) 1.00 1 1 2.2 0.00 1.0e+00 RILPL2
Arm fat mass (left) 2.20 4 0 0.0 -0.99 5.4e-03 CAMKMT CNIH2 FOXP1 NRBF2
Guilty feelings 2.91 1 0 0.0 0.00 1.0e+00 ZDHHC5
Mother's age at death 2.60 1 0 0.0 0.00 1.0e+00 CTNND1
Pain type(s) experienced in last month: Hip pain 1.64 1 0 0.0 0.00 1.0e+00 FOXP1
Supplements: Fish oil (including cod liver oil) 4.17 2 0 0.0 0.00 1.0e+00 CNIH2 DPP3
Alcohol drinker status: Never 2.34 1 0 0.0 0.00 1.0e+00 RILPL2
Ever smoked 1.98 1 0 0.0 0.00 1.0e+00 RILPL2
Basal metabolic rate 1.31 2 1 2.2 0.00 1.0e+00 CNIH2 RILPL2
Leg fat percentage (left) 3.83 4 2 4.4 -1.00 3.5e-04 CAMKMT CNIH2 FOXP1 NRBF2
Arm fat-free mass (left) 1.52 3 1 2.2 0.00 1.0e+00 CNIH2 NRBF2 RILPL2
Average weekly beer plus cider intake 4.09 1 0 0.0 0.00 1.0e+00 NRBF2
Diastolic blood pressure, automated reading 3.65 2 2 4.4 0.00 1.0e+00 NRBF2 RILPL2
Unable to work because of sickness or disability 3.12 1 0 0.0 0.00 1.0e+00 ZDHHC5
Commuting to job workplace: Cycle 4.55 3 0 0.0 0.00 1.0e+00 CNIH2 DPP3 FOXP1
Vascular/heart problems diagnosed by doctor 1.37 1 0 0.0 0.00 1.0e+00 NRBF2
Cholesterol lowering medication 1.46 1 0 0.0 0.00 1.0e+00 CNIH2
Pain experienced in last month 3.41 1 0 0.0 0.00 1.0e+00 FOXP1
Pack years of smoking 3.33 1 0 0.0 0.00 1.0e+00 NRBF2
Impedance of whole body 1.42 1 1 2.2 0.00 1.0e+00 NRBF2
Leg fat mass (left) 2.51 4 1 2.2 -1.00 4.6e-03 CAMKMT CNIH2 FOXP1 NRBF2
Arm predicted mass (left) 1.52 3 1 2.2 0.00 1.0e+00 CNIH2 NRBF2 RILPL2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.057 1.5
GTEx Adipose Visceral Omentum 3 0.147 1.6
GTEx Adrenal Gland 0 0.000 1.5
GTEx Artery Aorta 0 0.000 1.5
GTEx Artery Coronary 0 0.000 1.4
GTEx Artery Tibial 2 0.053 1.6
GTEx Brain Caudate basal ganglia 1 0.109 1.7
GTEx Brain Cerebellar Hemisphere 1 0.067 1.6
GTEx Brain Cerebellum 2 0.101 1.6
GTEx Brain Cortex 2 0.193 1.6
GTEx Brain Frontal Cortex BA9 1 0.108 1.7
GTEx Brain Hippocampus 0 0.000 1.6
GTEx Brain Hypothalamus 0 0.000 1.5
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.6
GTEx Brain Putamen basal ganglia 0 0.000 1.6
GTEx Breast Mammary Tissue 1 0.051 1.6
GTEx Breast Mammary Tissue (Male) 0 0.000 1.5
GTEx Breast Mammary Tissue (Female) 1 0.061 1.5
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.5
GTEx Cells Transformed fibroblasts 1 0.024 1.5
GTEx Colon Sigmoid 1 0.068 1.5
GTEx Colon Transverse 0 0.000 1.6
GTEx Esophagus Gastroesophageal Junction 1 0.069 1.5
GTEx Esophagus Mucosa 2 0.060 1.6
GTEx Esophagus Muscularis 3 0.093 1.5
GTEx Heart Atrial Appendage 1 0.063 1.5
GTEx Heart Left Ventricle 2 0.131 1.5
GTEx Liver 0 0.000 1.6
GTEx Lung 1 0.035 1.6
GTEx Muscle Skeletal 1 0.035 1.5
GTEx Nerve Tibial 2 0.046 1.5
GTEx Ovary 0 0.000 1.5
GTEx Pancreas 2 0.123 1.6
GTEx Pituitary 0 0.000 1.4
GTEx Prostate 0 0.000 1.6
GTEx Skin Not Sun Exposed Suprapubic 2 0.081 1.6
GTEx Skin Sun Exposed Lower leg 4 0.110 1.6
GTEx Small Intestine Terminal Ileum 0 0.000 1.8
GTEx Spleen 1 0.071 1.6
GTEx Stomach 0 0.000 1.6
GTEx Testis 1 0.032 1.5
GTEx Thyroid 3 0.075 1.5
GTEx Uterus 0 0.000 1.5
GTEx Vagina 0 0.000 1.7
GTEx Whole Blood 0 0.000 1.4
METSIM Adipose 2 0.043 1.4
NTR Blood 1 0.042 1.4
ROSMAP Brain Pre-frontal Cortex 2 0.046 1.5
YFS Blood 0 0.000 1.3
CommonMind Brain Pre-frontal Cortex 4 0.074 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 1 0.023 1.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Colon Adenocarcinoma 2 0.097 1.4
The Cancer Genome Atlas Esophageal Carcinoma 2 0.292 1.4
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.4
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 4 0.147 1.4
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 2 0.049 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Brain Lower Grade Glioma 4 0.093 1.5
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.4
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.4
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 1 0.060 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.5
The Cancer Genome Atlas Prostate Adenocarcinoma 2 0.043 1.4
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Soft Tissue Sarcoma 1 0.094 1.5
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.3
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.5
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.4
The Cancer Genome Atlas Thyroid Carcinoma 2 0.039 1.4
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2