Hub : Traits :

Average weekly red wine intake

77 significantly associated models · 26 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	43899918	45698128	1	1	4.2e-08	6.1e-08	1.0e+00	100	CAMKMT
2	3	70757099	71880670	1	1	2.7e-08	7.1e-09	2.3e-02	84	FOXP1
3	7	140705484	142344964	7	1	2.1e-11	1.1e-14	6.8e-05	73	MGAM
4	10	64195778	65606229	1	1	8.6e-08	3.3e-09	3.1e-03	75	NRBF2
5	11	56666189	58284951	7	2	3.2e-10	2.3e-09	1.0e+00	100	CTNND1 ZDHHC5
6	11	65549606	66963425	3	2	1.4e-08	9.8e-09	1.0e+00	100	CNIH2 DPP3
7	12	123049746	124449223	2	1	1.7e-08	1.5e-06	9.7e-01	100	RILPL2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Blood Platelet Count	13.68	3	3	6.7	0.00	1.0e+00	NRBF2 RILPL2 ZDHHC5
Qualifications: None of the above	11.34	5	3	6.7	-0.97	5.7e-03	CAMKMT FOXP1 NRBF2 RILPL2 ZDHHC5
Alcohol usually taken with meals	11.20	7	3	6.7	0.99	2.9e-05	CNIH2 CTNND1 FOXP1 MGAM NRBF2 RILPL2 ZDHHC5
Qualifications: A levels/AS levels or equivalent	9.24	6	3	6.7	0.96	2.2e-03	CAMKMT CNIH2 FOXP1 MGAM NRBF2 RILPL2
Qualifications: O levels/GCSEs or equivalent	8.06	4	2	4.4	1.00	2.0e-03	CAMKMT FOXP1 NRBF2 RILPL2
Qualifications: College or University degree	7.54	7	4	8.9	0.98	1.9e-04	CAMKMT CNIH2 DPP3 FOXP1 NRBF2 RILPL2 ZDHHC5
Alcohol intake frequency.	7.54	6	2	4.4	-1.00	2.6e-05	CNIH2 CTNND1 FOXP1 MGAM RILPL2 ZDHHC5
Fluid intelligence score	6.51	5	1	2.2	0.97	5.8e-03	CAMKMT FOXP1 NRBF2 RILPL2 ZDHHC5
Qualifications: nursing, teaching	6.17	2	1	2.2	0.00	1.0e+00	RILPL2 ZDHHC5
Overall health rating	5.58	4	1	2.2	0.07	9.3e-01	CNIH2 FOXP1 NRBF2 ZDHHC5
Verbal and Numeric Reasoning (VNR)	5.14	5	1	2.2	0.98	3.3e-03	CAMKMT FOXP1 NRBF2 RILPL2 ZDHHC5
Fed-up feelings	5.08	2	0	0.0	0.00	1.0e+00	CNIH2 ZDHHC5
Intelligence (Savage-Jansen 2018)	5.01	5	2	4.4	0.99	2.0e-03	CAMKMT FOXP1 NRBF2 RILPL2 ZDHHC5
Major Depression (MDD)	4.65	1	0	0.0	0.00	1.0e+00	ZDHHC5
Commuting to job workplace: Cycle	4.55	3	0	0.0	0.00	1.0e+00	CNIH2 DPP3 FOXP1
Frequency of unenthusiasm / disinterest in last 2 weeks	4.52	2	0	0.0	0.00	1.0e+00	NRBF2 ZDHHC5
Alcohol intake versus 10 years previously	4.33	3	0	0.0	0.00	1.0e+00	CAMKMT FOXP1 RILPL2
Frequency of tiredness / lethargy in last 2 weeks	4.29	2	1	2.2	0.00	1.0e+00	CTNND1 ZDHHC5
Schizophrenia vs Biploar Disorder	4.27	1	0	0.0	0.00	1.0e+00	ZDHHC5
Depression (Nagel 2018)	4.21	2	1	2.2	0.00	1.0e+00	NRBF2 ZDHHC5
Supplements: Fish oil (including cod liver oil)	4.17	2	0	0.0	0.00	1.0e+00	CNIH2 DPP3
Average weekly beer plus cider intake	4.09	1	0	0.0	0.00	1.0e+00	NRBF2
Triglycerides	4.07	1	1	2.2	0.00	1.0e+00	NRBF2
Mineral and other dietary supplements	4.00	1	0	0.0	0.00	1.0e+00	NRBF2
Leg fat percentage (left)	3.83	4	2	4.4	-1.00	3.5e-04	CAMKMT CNIH2 FOXP1 NRBF2
Leg fat percentage (right)	3.75	4	1	2.2	-1.00	1.3e-03	CAMKMT CNIH2 FOXP1 NRBF2
Pack years adult smoking proportion	3.74	1	0	0.0	0.00	1.0e+00	NRBF2
Sitting height	3.73	3	2	4.4	0.00	1.0e+00	CAMKMT RILPL2 ZDHHC5
Diastolic blood pressure, automated reading	3.65	2	2	4.4	0.00	1.0e+00	NRBF2 RILPL2
Breast Cancer	3.52	3	0	0.0	0.00	1.0e+00	CNIH2 DPP3 NRBF2
Lung FVC	3.52	5	1	2.2	-0.16	8.0e-01	CNIH2 DPP3 FOXP1 NRBF2 RILPL2
Worry too long after embarrassment	3.48	1	1	2.2	0.00	1.0e+00	ZDHHC5
Blood White Count	3.45	2	1	2.2	0.00	1.0e+00	FOXP1 NRBF2
Chronotype (morning person)	3.44	3	0	0.0	0.00	1.0e+00	CAMKMT CTNND1 ZDHHC5
Pain experienced in last month	3.41	1	0	0.0	0.00	1.0e+00	FOXP1
Age at first live birth	3.39	1	0	0.0	0.00	1.0e+00	NRBF2
Pack years of smoking	3.33	1	0	0.0	0.00	1.0e+00	NRBF2
Prospective memory result	3.31	1	0	0.0	0.00	1.0e+00	CAMKMT
Frequency of depressed mood in last 2 weeks	3.30	1	0	0.0	0.00	1.0e+00	ZDHHC5
Body fat percentage	3.20	4	2	4.4	-0.97	2.9e-02	CAMKMT CNIH2 FOXP1 ZDHHC5
Neuroticism	3.17	2	1	2.2	0.00	1.0e+00	CTNND1 ZDHHC5
Unable to work because of sickness or disability	3.12	1	0	0.0	0.00	1.0e+00	ZDHHC5
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.10	2	0	0.0	0.00	1.0e+00	FOXP1 NRBF2
Neuroticism (Nagel 2018)	2.95	1	1	2.2	0.00	1.0e+00	ZDHHC5
Current tobacco smoking	2.94	1	0	0.0	0.00	1.0e+00	NRBF2
Guilty feelings	2.91	1	0	0.0	0.00	1.0e+00	ZDHHC5
HDL Cholesterol	2.82	1	0	0.0	0.00	1.0e+00	NRBF2
Vitamin and mineral supplements	2.81	1	0	0.0	0.00	1.0e+00	CNIH2
Neuroticism score	2.81	1	1	2.2	0.00	1.0e+00	ZDHHC5
Trunk fat percentage	2.80	4	2	4.4	-0.98	2.4e-02	CAMKMT CNIH2 FOXP1 ZDHHC5
Smoking status: Current	2.78	1	0	0.0	0.00	1.0e+00	NRBF2
Height	2.76	5	5	11.1	0.84	7.8e-02	CAMKMT CNIH2 NRBF2 RILPL2 ZDHHC5
Depressed Affect (Nagel 2018)	2.74	2	0	0.0	0.00	1.0e+00	CNIH2 ZDHHC5
Supplements: Zinc	2.73	1	0	0.0	0.00	1.0e+00	NRBF2
Arm fat percentage (right)	2.68	4	1	2.2	-0.98	1.6e-02	CAMKMT CNIH2 FOXP1 ZDHHC5
Comparative height size at age 10	2.68	2	1	2.2	0.00	1.0e+00	CAMKMT RILPL2
Lung FEV1/FVC ratio	2.67	2	2	4.4	0.00	1.0e+00	NRBF2 ZDHHC5
Standing height	2.66	5	3	6.7	0.82	8.9e-02	CAMKMT CNIH2 NRBF2 RILPL2 ZDHHC5
Arm fat percentage (left)	2.65	4	1	2.2	-0.98	1.5e-02	CAMKMT CNIH2 FOXP1 ZDHHC5
Leg fat mass (right)	2.61	4	1	2.2	-0.99	7.8e-03	CAMKMT CNIH2 FOXP1 NRBF2
Mother's age at death	2.60	1	0	0.0	0.00	1.0e+00	CTNND1
Long-standing illness, disability or infirmity	2.56	2	0	0.0	0.00	1.0e+00	CNIH2 FOXP1
Leg fat mass (left)	2.51	4	1	2.2	-1.00	4.6e-03	CAMKMT CNIH2 FOXP1 NRBF2
Loneliness, isolation	2.50	1	0	0.0	0.00	1.0e+00	ZDHHC5
Schizophrenia (2018)	2.49	2	0	0.0	0.00	1.0e+00	FOXP1 ZDHHC5
Body mass index (BMI)	2.47	3	1	2.2	0.00	1.0e+00	CAMKMT FOXP1 NRBF2
Schizophrenia (2014)	2.40	2	0	0.0	0.00	1.0e+00	FOXP1 ZDHHC5
BMI	2.40	4	2	4.4	-0.99	7.2e-03	CAMKMT CNIH2 FOXP1 NRBF2
Allergy or Eczema	2.39	1	0	0.0	0.00	1.0e+00	RILPL2
Waist Hip Ratio (WHR)	2.37	2	1	2.2	0.00	1.0e+00	NRBF2 RILPL2
Alcohol drinker status: Never	2.34	1	0	0.0	0.00	1.0e+00	RILPL2
Type 2 Diabetes (T2D) (2018)	2.33	1	0	0.0	0.00	1.0e+00	CAMKMT
Age at last live birth	2.33	1	0	0.0	0.00	1.0e+00	NRBF2
Whole body fat mass	2.32	2	1	2.2	0.00	1.0e+00	CNIH2 FOXP1
Smoking Status	2.31	1	0	0.0	0.00	1.0e+00	FOXP1
Trunk fat mass	2.24	2	1	2.2	0.00	1.0e+00	CNIH2 FOXP1
Impedance of arm (right)	2.23	2	1	2.2	0.00	1.0e+00	NRBF2 ZDHHC5
Arm fat mass (right)	2.22	4	0	0.0	-1.00	5.0e-03	CAMKMT CNIH2 FOXP1 NRBF2
Townsend deprivation index at recruitment	2.21	1	0	0.0	0.00	1.0e+00	ZDHHC5
Arm fat mass (left)	2.20	4	0	0.0	-0.99	5.4e-03	CAMKMT CNIH2 FOXP1 NRBF2
Breastfed as a baby	2.15	1	0	0.0	0.00	1.0e+00	RILPL2
Systolic Blood Pressure	2.10	2	1	2.2	0.00	1.0e+00	CTNND1 ZDHHC5
Forced expiratory volume in 1-second (FEV1), Best measure	2.08	2	0	0.0	0.00	1.0e+00	FOXP1 ZDHHC5
Forced expiratory volume in 1-second (FEV1)	2.07	2	1	2.2	0.00	1.0e+00	FOXP1 ZDHHC5
Impedance of arm (left)	2.04	2	1	2.2	0.00	1.0e+00	NRBF2 ZDHHC5
Headache pain in last month	2.04	2	0	0.0	0.00	1.0e+00	FOXP1 ZDHHC5
Mood swings	2.04	1	0	0.0	0.00	1.0e+00	CNIH2
Heel T-Score	2.03	2	2	4.4	0.00	1.0e+00	RILPL2 ZDHHC5
Allergy	2.03	1	0	0.0	0.00	1.0e+00	RILPL2
Ever smoked	1.98	1	0	0.0	0.00	1.0e+00	RILPL2
Waist circumference	1.94	3	0	0.0	0.00	1.0e+00	CNIH2 FOXP1 NRBF2
Worrier / anxious feelings	1.92	1	1	2.2	0.00	1.0e+00	ZDHHC5
Forced vital capacity (FVC)	1.91	1	1	2.2	0.00	1.0e+00	FOXP1
Systolic blood pressure, automated reading	1.86	1	0	0.0	0.00	1.0e+00	ZDHHC5
Exposure to tobacco smoke outside home	1.86	1	0	0.0	0.00	1.0e+00	NRBF2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.85	1	0	0.0	0.00	1.0e+00	ZDHHC5
Hand grip strength (right)	1.83	1	0	0.0	0.00	1.0e+00	FOXP1
Forced vital capacity (FVC), Best measure	1.79	2	1	2.2	0.00	1.0e+00	CAMKMT FOXP1
Hand grip strength (left)	1.77	2	0	0.0	0.00	1.0e+00	FOXP1 ZDHHC5
Sensitivity / hurt feelings	1.74	1	0	0.0	0.00	1.0e+00	ZDHHC5
Age at First Birth	1.72	1	0	0.0	0.00	1.0e+00	NRBF2
Trunk predicted mass	1.70	2	1	2.2	0.00	1.0e+00	RILPL2 ZDHHC5
Trunk fat-free mass	1.69	2	1	2.2	0.00	1.0e+00	RILPL2 ZDHHC5
Tense / 'highly strung'	1.68	1	0	0.0	0.00	1.0e+00	ZDHHC5
Peak expiratory flow (PEF)	1.66	1	0	0.0	0.00	1.0e+00	ZDHHC5
Weight	1.65	3	1	2.2	0.00	1.0e+00	CNIH2 FOXP1 RILPL2
High blood pressure (siblings)	1.64	1	0	0.0	0.00	1.0e+00	NRBF2
Pain type(s) experienced in last month: Hip pain	1.64	1	0	0.0	0.00	1.0e+00	FOXP1
Blood Red Count	1.57	5	1	2.2	-0.69	2.0e-01	CAMKMT DPP3 NRBF2 RILPL2 ZDHHC5
Had menopause	1.53	1	0	0.0	0.00	1.0e+00	RILPL2
Arm fat-free mass (right)	1.53	3	1	2.2	0.00	1.0e+00	CNIH2 RILPL2 ZDHHC5
Arm fat-free mass (left)	1.52	3	1	2.2	0.00	1.0e+00	CNIH2 NRBF2 RILPL2
Arm predicted mass (left)	1.52	3	1	2.2	0.00	1.0e+00	CNIH2 NRBF2 RILPL2
Cholesterol lowering medication	1.46	1	0	0.0	0.00	1.0e+00	CNIH2
Impedance of whole body	1.42	1	1	2.2	0.00	1.0e+00	NRBF2
Age when periods started (menarche)	1.41	1	0	0.0	0.00	1.0e+00	NRBF2
Pulse rate, automated reading	1.41	1	1	2.2	0.00	1.0e+00	ZDHHC5
Hip circumference	1.40	2	0	0.0	0.00	1.0e+00	CNIH2 RILPL2
Arm predicted mass (right)	1.40	2	1	2.2	0.00	1.0e+00	CNIH2 RILPL2
Whole body fat-free mass	1.38	1	1	2.2	0.00	1.0e+00	RILPL2
Whole body water mass	1.38	1	1	2.2	0.00	1.0e+00	RILPL2
Vascular/heart problems diagnosed by doctor	1.37	1	0	0.0	0.00	1.0e+00	NRBF2
Worry (Nagel 2018)	1.35	1	0	0.0	0.00	1.0e+00	ZDHHC5
Stomach or abdominal pain in last month	1.31	1	0	0.0	0.00	1.0e+00	FOXP1
Hypertension (Self-reported)	1.31	1	0	0.0	0.00	1.0e+00	NRBF2
Basal metabolic rate	1.31	2	1	2.2	0.00	1.0e+00	CNIH2 RILPL2
High blood pressure	1.20	1	0	0.0	0.00	1.0e+00	NRBF2
Blood Eosinophil Count	1.16	3	1	2.2	0.00	1.0e+00	CTNND1 RILPL2 ZDHHC5
Number of treatments/medications taken	1.16	1	0	0.0	0.00	1.0e+00	FOXP1
Comparative body size at age 10	1.15	1	0	0.0	0.00	1.0e+00	DPP3
Relative age of first facial hair	1.12	1	0	0.0	0.00	1.0e+00	NRBF2
Leg fat-free mass (left)	1.09	1	1	2.2	0.00	1.0e+00	RILPL2
Heel bone mineral density (BMD) T-score, automated (left)	1.08	1	0	0.0	0.00	1.0e+00	RILPL2
Leg predicted mass (left)	1.08	1	1	2.2	0.00	1.0e+00	RILPL2
Leg fat-free mass (right)	1.01	1	1	2.2	0.00	1.0e+00	RILPL2
Leg predicted mass (right)	1.00	1	1	2.2	0.00	1.0e+00	RILPL2
Impedance of leg (left)	0.92	2	0	0.0	0.00	1.0e+00	NRBF2 RILPL2
Impedance of leg (right)	0.86	1	0	0.0	0.00	1.0e+00	NRBF2
Hair Pigment	0.25	2	1	2.2	0.00	1.0e+00	CNIH2 RILPL2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Small Intestine Terminal Ileum	0	0.000	1.8
GTEx	Brain Caudate basal ganglia	1	0.109	1.7
GTEx	Brain Frontal Cortex BA9	1	0.108	1.7
GTEx	Vagina	0	0.000	1.7
GTEx	Adipose Visceral Omentum	3	0.147	1.6
GTEx	Artery Tibial	2	0.053	1.6
GTEx	Brain Cerebellar Hemisphere	1	0.067	1.6
GTEx	Brain Cerebellum	2	0.101	1.6
GTEx	Brain Cortex	2	0.193	1.6
GTEx	Brain Hippocampus	0	0.000	1.6
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.6
GTEx	Brain Putamen basal ganglia	0	0.000	1.6
GTEx	Breast Mammary Tissue	1	0.051	1.6
GTEx	Colon Transverse	0	0.000	1.6
GTEx	Esophagus Mucosa	2	0.060	1.6
GTEx	Liver	0	0.000	1.6
GTEx	Lung	1	0.035	1.6
GTEx	Pancreas	2	0.123	1.6
GTEx	Prostate	0	0.000	1.6
GTEx	Skin Not Sun Exposed Suprapubic	2	0.081	1.6
GTEx	Skin Sun Exposed Lower leg	4	0.110	1.6
GTEx	Spleen	1	0.071	1.6
GTEx	Stomach	0	0.000	1.6
GTEx	Adipose Subcutaneous	2	0.057	1.5
GTEx	Adrenal Gland	0	0.000	1.5
GTEx	Artery Aorta	0	0.000	1.5
GTEx	Brain Hypothalamus	0	0.000	1.5
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.5
GTEx	Breast Mammary Tissue (Female)	1	0.061	1.5
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.5
GTEx	Cells Transformed fibroblasts	1	0.024	1.5
GTEx	Colon Sigmoid	1	0.068	1.5
GTEx	Esophagus Gastroesophageal Junction	1	0.069	1.5
GTEx	Esophagus Muscularis	3	0.093	1.5
GTEx	Heart Atrial Appendage	1	0.063	1.5
GTEx	Heart Left Ventricle	2	0.131	1.5
GTEx	Muscle Skeletal	1	0.035	1.5
GTEx	Nerve Tibial	2	0.046	1.5
GTEx	Ovary	0	0.000	1.5
GTEx	Testis	1	0.032	1.5
GTEx	Thyroid	3	0.075	1.5
GTEx	Uterus	0	0.000	1.5
ROSMAP	Brain Pre-frontal Cortex	2	0.046	1.5
The Cancer Genome Atlas	Brain Lower Grade Glioma	4	0.093	1.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.5
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Soft Tissue Sarcoma	1	0.094	1.5
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.5
GTEx	Artery Coronary	0	0.000	1.4
GTEx	Pituitary	0	0.000	1.4
GTEx	Whole Blood	0	0.000	1.4
METSIM	Adipose	2	0.043	1.4
NTR	Blood	1	0.042	1.4
CommonMind	Brain Pre-frontal Cortex	4	0.074	1.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	1	0.023	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	2	0.097	1.4
The Cancer Genome Atlas	Esophageal Carcinoma	2	0.292	1.4
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.4
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	4	0.147	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	2	0.049	1.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.040	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	2	0.039	1.4
YFS	Blood	0	0.000	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2