Hub : Genes

CLEC5A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0570	0.0200	1.3e-05	0.031	0.039	0.040	0.039	0.040	9.2e-05	1.6e-05	1.1e-05	1.5e-05	1.1e-05
2	NTR	Blood	0.0647	0.0156	1.3e-11	0.022	0.038	0.043	0.041	0.044	8.7e-08	2.5e-12	1.1e-13	3.5e-13	5.2e-14
3	TCGA	Brain Lower Grade Glioma	0.0512	0.0369	1.4e-03	0.027	0.019	0.020	NA	0.021	3.8e-04	2.6e-03	2.3e-03	NA	1.7e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.4	0.7	-0.8	-0.2	-0.7
Bipolar Disorder or Schizophrenia	0.3	0.7	1.2	-1.1	-0.4	-0.8
Depressed Affect (Nagel 2018)	0.1	0.3	0.7	0.3	-0.8	0.1
Depression (Nagel 2018)	0.4	0.5	0.8	-0.9	-0.2	-0.9
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.6	1.6	1.0	1.1
Neuroticism (Nagel 2018)	0.3	0.6	1.1	1.1	-0.4	0.7
Schizophrenia (2018)	0.1	0.3	0.5	-0.7	-0.4	-0.4
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.4	-0.4	0.0
Worry (Nagel 2018)	0.2	0.5	0.9	0.7	1.0	0.4
Alzheimer’s Disease (in mother)	1.2	1.4	1.6	1.1	-1.2	1.3
Alzheimer’s Disease (in father)	1.5	1.7	2.1	1.4	-1.2	1.2
Alzheimer’s Disease (including proxy)	3.4	4.9	5.6	2.3	-2.4	2.0
Crohns Disease (2017)	2.5	5.4	7.6	1.9	-2.2	2.7
Irritable Bowel Disease (IBD)	2.1	5.1	7.0	2.0	-2.6	2.1
Ulcerative Colitis (UC)	0.7	1.2	2.3	1.1	-1.5	0.4
Major Depression (MDD)	0.6	0.7	1.3	-1.1	0.3	-0.9
Reaction Time	1.5	2.9	3.8	1.9	-1.2	1.9
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.8	1.7	0.6	0.8
Breast Cancer	0.4	0.9	1.1	0.8	-1.1	1.0
Ovarian Cancer	0.3	0.4	0.6	0.7	0.3	0.8
Prostate Cancer	0.4	0.6	0.8	-0.9	-0.8	-0.7
Age at First Birth	1.3	1.9	2.2	1.5	-1.4	1.2
Bipolar Disorder (2011)	0.1	0.1	0.3	-0.5	0.2	0.0
Body Mass Index (BMI) (2010)	0.4	0.6	1.2	1.1	-0.3	0.6
Coronary Artery Disease (CAD)	3.4	4.0	9.6	-3.1	1.6	0.0
Crohns Disease (2012)	1.8	2.9	4.2	1.7	-1.2	2.0
Mean Putamen Volume	0.4	0.4	0.9	-0.9	0.3	-0.5
Fasting Glucose	1.1	1.3	2.2	1.2	-0.4	1.5
HbA1C	0.1	0.1	0.1	-0.2	0.4	0.2
HDL Cholesterol	0.1	0.1	0.3	0.3	-0.5	0.1
LDL Cholesterol	0.9	1.4	3.9	0.2	2.0	-0.4
Lupus	1.8	2.8	4.8	-0.9	2.2	-1.7
Neuroticism (2016)	0.1	0.2	0.5	0.7	-0.3	0.3
Primary Biliary Cirrhosis	1.2	1.7	3.2	-1.8	0.2	-1.4
Rheumatoid Arthritis	0.5	0.7	1.9	-1.4	0.4	0.0
Schizophrenia (2014)	0.5	1.2	1.8	-1.3	0.8	-1.1
Triglycerides	0.6	0.9	1.9	-0.5	1.4	-0.8
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.1	-0.5	-0.2
Ulcerative Colitis	0.6	0.9	2.5	0.4	-1.6	-0.0
Blood Eosinophil Count	0.3	2.3	2.8	-1.7	1.6	-1.2
Blood Platelet Count	0.1	0.6	0.9	-0.9	0.6	-0.9
Blood Red Count	0.3	3.0	4.2	-2.0	1.4	-1.7
Blood White Count	1.1	7.8	8.1	-2.9	2.8	-2.8
Heel T-Score	0.0	0.2	0.4	-0.6	-0.2	-0.3
BMI	0.6	3.3	7.5	-1.5	0.3	-2.7
Height	0.0	0.0	0.1	0.2	-0.3	0.1
Waist Hip Ratio (WHR)	0.0	0.1	0.2	-0.3	-0.4	-0.1
Systolic Blood Pressure	0.3	1.3	2.8	-1.0	0.3	-1.7
Smoking Status	0.0	0.0	0.0	0.2	-0.2	0.1
Allergy or Eczema	0.5	1.2	2.2	1.5	-0.4	1.2
Cardiovascular Disease	0.5	1.5	2.1	-1.4	0.8	-1.4
Hypothyroidism (self reported)	0.4	1.0	2.4	1.6	0.5	0.6
Respiratory disease	0.9	2.1	3.0	1.7	-1.7	0.7
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.3	0.6	1.5	0.9
Lung FEV1/FVC ratio	0.3	1.7	2.7	1.2	-1.0	1.6
Lung FVC	0.3	1.6	3.0	1.7	0.2	1.3
Neuroticism	0.6	1.4	2.2	1.5	-0.9	1.1
Chronotype (morning person)	0.1	0.3	0.6	0.1	0.4	0.8
Hair Pigment	0.1	2.5	6.3	0.7	-2.5	0.8
Tanning	0.6	7.6	9.1	-2.9	3.0	-2.3
Hand grip strength (left)	0.3	0.8	1.2	-0.5	1.1	-0.9
Number of treatments/medications taken	1.3	2.3	6.3	0.8	-2.5	0.3
Average weekly spirits intake	2.2	2.7	4.7	2.2	-0.5	1.8
Sensitivity / hurt feelings	0.3	0.6	0.8	0.9	0.2	0.9
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.1	-0.4	0.2	-0.4
Hearing difficulty/problems: Yes	0.5	0.7	2.1	1.5	-0.3	0.2
Relative age of first facial hair	0.2	0.4	1.1	-0.3	-1.1	-0.1
Other serious medical condition/disability diagnosed by doctor	2.3	3.0	5.3	2.3	-0.8	1.7
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.3	-1.1	0.4	-0.8
Ever had hysterectomy (womb removed)	1.0	1.1	2.7	0.5	-1.7	0.6
Systolic blood pressure, automated reading	0.4	1.2	2.0	-0.8	-0.9	-1.4
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	1.1	0.8	-1.0	1.0
Angina	0.3	0.4	1.0	0.1	-0.3	1.0
Medication for hormone replacement therapy	0.8	0.9	2.1	-0.7	0.2	-1.5
Vitamin and mineral supplements	0.6	0.8	1.0	0.8	1.0	0.8
Supplements: Zinc	0.5	0.6	0.9	0.8	-0.3	0.9
Medication: Co-codamol	3.5	4.1	8.6	1.4	-2.9	1.3
Medication: Metformin	0.2	0.2	0.4	0.2	0.5	0.6
Diabetes (father)	0.5	0.7	1.3	0.8	-1.1	0.3
Diabetes (mother)	0.9	1.2	1.8	-1.2	0.6	-1.3
Severe depression (siblings)	0.4	0.4	0.9	-0.5	-0.9	-0.3
Pack years adult smoking proportion	0.1	0.1	0.1	0.3	0.3	-0.2
Impedance of leg (right)	0.4	2.0	4.2	1.3	0.1	2.0
Leg fat-free mass (left)	0.4	1.9	3.5	-1.3	-0.7	-1.9
Trunk fat percentage	0.1	0.3	0.9	0.3	-1.0	0.0
Hand grip strength (right)	0.1	0.1	0.3	0.0	0.5	-0.4
Townsend deprivation index at recruitment	0.5	0.7	1.8	-0.1	1.4	-0.5
Current tobacco smoking	0.2	0.4	0.6	0.6	-0.8	0.4
Average weekly fortified wine intake	0.1	0.1	0.1	0.3	-0.0	0.3
Maternal smoking around birth	0.1	0.1	0.3	-0.1	-0.5	0.0
Fed-up feelings	0.5	0.8	2.2	0.0	-1.5	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	-0.7	0.2	-0.9
Relative age voice broke	0.2	0.4	1.0	-0.1	1.0	-0.1
Taking other prescription medications	5.0	7.7	8.7	2.9	-2.9	2.4
Age when periods started (menarche)	0.6	1.4	2.3	-1.1	1.5	-0.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.9	0.5	-0.9	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.8	-0.1	0.9	-0.4
Tinnitus: Yes, but not now, but have in the past	3.0	3.2	5.4	-1.6	2.3	-1.3
Qualifications: CSEs or equivalent	0.0	0.1	0.2	-0.0	-0.4	-0.0
Serious illness, injury or assault to yourself	1.5	1.8	3.7	1.9	-0.9	1.0
High blood pressure	0.5	1.5	3.0	-1.7	0.4	-1.2
Hayfever, allergic rhinitis or eczema	1.3	2.8	4.0	1.8	-1.2	2.0
Multivitamins +/- minerals	2.6	3.3	5.1	-2.1	-0.5	-2.3
Stomach or abdominal pain in last month	0.5	0.6	0.9	0.9	-0.7	0.6
Supplements: Glucosamine	0.2	0.3	0.5	-0.2	-0.7	0.5
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.6	1.3	0.3	1.0
Medication: Atenolol	0.5	0.7	1.3	-1.2	0.3	-0.7
Medication: Levothyroxine sodium	0.2	0.4	0.6	0.8	0.6	0.4
Sitting height	0.0	0.3	0.4	-0.5	0.7	-0.5
Chronic bronchitis/emphysema (father)	0.4	0.4	0.7	0.5	-0.6	0.8
High blood pressure (mother)	0.0	0.0	0.0	0.1	-0.2	-0.1
Body mass index (BMI)	0.3	1.4	3.2	-1.0	-0.2	-1.8
Impedance of leg (left)	0.3	1.7	2.8	1.0	1.1	1.7
Leg predicted mass (left)	0.4	2.0	3.5	-1.4	-0.8	-1.9
Trunk fat mass	0.1	0.5	0.8	-0.6	-0.6	-0.9
Waist circumference	0.2	0.8	1.3	-0.8	-0.8	-1.1
Number of incorrect matches in round	0.5	0.8	1.5	0.9	-1.2	0.3
Past tobacco smoking	0.1	0.1	0.4	-0.0	-0.6	-0.0
Alcohol usually taken with meals	1.4	2.2	5.2	2.3	-0.3	1.2
Nervous feelings	0.1	0.2	0.3	0.5	0.6	0.1
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	4.2	1.6	-1.3	2.0
Hearing difficulty/problems with background noise	0.2	0.2	0.4	0.4	0.4	-0.6
Hair/balding pattern: Pattern 2	0.3	0.3	0.6	-0.2	-0.8	-0.6
Had menopause	1.0	1.2	1.6	1.2	-0.8	1.2
Had other major operations	0.2	0.2	0.7	0.2	0.1	-0.8
Forced vital capacity (FVC)	1.1	4.1	8.6	-1.0	2.9	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.1	-1.1	1.8	-1.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.3	-0.0	1.1	-0.1
Qualifications: None of the above	1.1	2.4	3.7	-1.9	-1.1	-1.5
Financial difficulties in last 2 years	1.1	1.5	2.4	1.1	-1.5	0.9
Mouth/teeth dental problems	2.1	3.3	5.2	-2.3	1.1	-1.8
Heart attack	0.2	0.3	0.3	-0.5	0.5	0.4
Allergy	1.1	2.6	3.3	-1.4	1.6	-1.8
Pain all over the body in last month	0.3	0.3	0.9	-0.1	-1.0	-0.0
Diabetes (self-reported)	1.1	1.7	3.3	1.3	0.0	1.8
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	3.0	-1.7	1.2	-1.7
Medication: Ramipril	0.7	0.9	1.7	-1.3	0.0	-0.9
Medication: Simvastatin	2.4	3.6	4.7	2.0	-1.5	2.2
Fluid intelligence score	0.5	1.0	1.9	1.4	0.9	0.6
Illnesses of siblings	0.8	1.2	2.9	-0.6	1.7	-0.5
Neuroticism score	0.0	0.1	0.1	0.3	-0.1	0.4
Weight	0.3	1.7	3.3	-1.3	-0.2	-1.8
Impedance of arm (right)	0.7	3.1	6.3	1.7	-0.1	2.5
Arm fat percentage (right)	0.1	0.3	0.5	-0.2	-0.7	-0.6
Trunk fat-free mass	0.5	2.6	4.3	-1.8	-0.2	-2.1
Hip circumference	0.1	0.5	0.9	-0.5	-0.5	-1.0
Time employed in main current job	0.2	0.2	0.4	-0.6	0.2	-0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.3	-0.5	-0.2	-0.4
Father’s age at death	0.2	0.3	0.6	-0.3	0.8	0.4
Worrier / anxious feelings	0.2	0.4	0.6	0.4	0.7	0.8
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	2.4	1.5	-0.6	1.5
Falls in the last year	0.4	0.6	1.7	0.4	-1.3	0.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	0.2	0.0	0.6
Number of live births	0.5	0.7	0.9	-0.9	0.8	-1.0
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	8.5	-0.6	2.9	-1.2
Pulse rate	0.1	0.2	0.4	0.6	0.6	-0.2
Happiness	0.4	0.5	0.7	0.8	-0.8	0.3
Noisy workplace	4.2	5.2	7.1	1.5	-2.7	2.4
Qualifications: A levels/AS levels or equivalent	3.3	7.4	12.4	3.5	-1.6	2.7
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.5	-0.7	0.7	-0.5
Mouth/teeth dental problems: Dentures	0.6	1.0	1.7	1.3	-0.4	1.1
Asthma	0.9	1.8	4.8	0.6	-2.2	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.1	-0.5	-1.1	-0.9
Medication: Cholesterol lowering	0.4	0.7	1.4	0.8	-0.0	1.2
Depression (self-reported)	1.9	2.3	4.3	2.1	0.7	1.4
Medication: Lansoprazole	0.4	0.5	1.1	-0.6	0.2	-1.1
Prospective memory result	1.0	1.3	2.9	0.3	-1.7	0.9
Lung cancer (father)	1.3	1.5	2.4	-1.2	1.5	-0.8
Illnesses of mother	1.2	1.4	2.3	-1.1	1.5	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	5.9	-0.9	2.4	-1.5
Pulse wave Arterial Stiffness index	0.5	0.6	0.9	-0.9	-0.2	-1.0
Impedance of arm (left)	0.7	3.1	6.3	1.8	-0.2	2.5
Arm fat mass (right)	0.3	1.2	2.4	-1.1	-0.3	-1.6
Trunk predicted mass	0.5	2.6	4.3	-1.8	-0.1	-2.1
Standing height	0.1	0.5	1.2	-1.1	0.2	-0.6
Length of working week for main job	0.2	0.3	0.6	0.2	-0.4	-0.8
Exposure to tobacco smoke at home	0.7	0.8	1.6	0.5	-1.3	0.6
Breastfed as a baby	0.8	1.0	1.4	0.9	1.2	1.0
Tense / ‘highly strung’	0.1	0.1	0.2	-0.3	0.4	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.0	1.4	0.1	0.7
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	-0.0	0.1	0.4
Birth weight of first child	0.8	1.4	2.0	1.4	-0.9	1.1
Peak expiratory flow (PEF)	1.8	4.1	8.4	-1.1	2.9	-1.7
Pulse wave reflection index	0.4	0.5	0.7	-0.8	0.3	-0.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.3	0.3	-0.0	1.1
Loud music exposure frequency	0.6	0.7	0.9	0.7	-1.0	0.8
Qualifications: O levels/GCSEs or equivalent	2.3	3.7	4.8	2.2	-1.5	2.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.0	0.8	-0.0	1.0
Blood clot in the leg (DVT)	1.7	2.2	3.6	1.9	-0.7	1.6
Medication: Paracetamol	1.1	1.8	2.9	1.7	-1.2	1.0
Headache pain in last month	0.4	0.8	1.6	0.8	-1.3	0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	0.2	0.6	-0.4
Glaucoma (self-reported)	1.0	1.1	2.9	-0.8	-0.0	-1.7
Gout (self-reported)	2.6	3.5	5.8	1.8	-2.4	1.3
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	3.8	2.0	0.2	1.2
Medication: Amlodipine	0.9	1.3	2.8	-1.7	-0.2	-1.1
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.7	0.3	-1.3	0.1
Birth weight	0.3	0.6	1.1	0.4	-0.7	1.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.0	0.3	-1.0	1.0
High blood pressure (siblings)	0.3	0.4	0.8	-0.9	-0.2	-0.5
Forced vital capacity (FVC), Best measure	1.3	4.6	8.2	-1.3	2.9	-2.0
Body fat percentage	0.0	0.2	0.4	-0.0	-0.7	-0.3
Leg fat percentage (right)	0.0	0.1	0.2	-0.1	-0.5	-0.4
Arm fat-free mass (right)	0.4	1.9	3.2	-1.5	-0.4	-1.8
Exposure to tobacco smoke outside home	0.5	0.7	1.0	0.9	-1.0	0.6
Comparative body size at age 10	0.0	0.1	0.1	-0.3	-0.3	-0.2
Number of full brothers	0.5	0.6	1.3	-0.5	1.1	-0.5
Worry too long after embarrassment	0.7	1.2	1.9	0.8	-1.4	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.8	2.4	1.6	0.2	0.3
Wheeze or whistling in the chest in last year	0.7	1.2	3.5	-0.4	-1.9	-0.2
Number of children fathered	1.2	1.4	2.5	-1.3	-0.3	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	3.4	3.9	5.9	2.4	-0.7	2.3
Age at first live birth	0.5	1.0	1.4	1.1	-0.4	1.2
Pulse wave peak to peak time	0.4	0.5	0.8	0.8	0.1	0.9
Health satisfaction	1.2	1.5	2.9	-1.1	0.6	-1.7
Shortness of breath walking on level ground	0.6	0.7	1.2	-1.1	0.1	-1.0
Qualifications: College or University degree	0.1	0.4	1.1	1.1	0.2	0.1
Eye problems/disorders: None of the above	2.0	2.3	6.4	-0.6	2.5	-0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.6	0.2	-0.8	-0.0
Emphysema/chronic bronchitis	1.3	1.4	2.3	-1.5	-0.9	-1.1
Medication for pain relief, constipation, heartburn	1.5	2.6	5.6	-1.3	2.4	-0.5
Neck or shoulder pain in last month	1.6	2.3	3.4	1.9	-1.2	1.4
Medication: Blood pressure	0.6	1.1	1.5	-1.2	-0.9	-0.9
Angina (self-reported)	0.3	0.4	1.1	0.1	-0.2	1.0
Migraine (self-reported)	0.2	0.2	0.6	0.4	-0.8	0.0
Medication: Ibuprofen	1.4	1.7	3.7	-0.5	-1.9	-1.1
Medication: Allopurinol	2.6	3.4	4.3	2.1	-2.0	1.4
Medication: Omeprazole	2.0	2.4	3.6	1.9	-1.1	1.5
Medication: Seretide 50 evohaler	0.2	0.2	0.7	-0.1	-0.8	-0.1
Mean time to correctly identify matches	1.7	3.3	4.9	2.0	-0.9	2.2
Heart disease (mother)	0.0	0.0	0.1	0.1	-0.2	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.3	0.1	1.5	-1.4
Whole body fat mass	0.2	0.7	1.2	-0.8	-0.5	-1.1
Leg fat mass (right)	0.3	1.0	1.9	-1.0	-0.3	-1.4
Arm predicted mass (right)	0.4	2.0	3.4	-1.5	-0.4	-1.9
Pulse rate, automated reading	0.0	0.1	0.4	-0.1	0.6	-0.1
Alcohol intake frequency.	2.3	5.2	9.7	-3.1	0.6	-2.4
Comparative height size at age 10	0.1	0.3	0.8	0.3	-0.1	0.9
Number of full sisters	2.2	2.7	5.6	-1.4	-0.7	-2.4
Suffer from ‘nerves’	0.3	0.4	1.1	0.2	1.1	0.2
Overall health rating	0.9	2.0	3.7	-1.6	0.1	-1.9
Chest pain or discomfort	0.3	0.4	1.2	0.0	-1.1	0.1
Had major operations	0.1	0.1	0.2	-0.5	0.1	0.0
Age at last live birth	0.1	0.1	0.2	0.2	0.5	0.4
Family relationship satisfaction	0.4	0.5	1.4	0.1	0.0	1.2
Leg pain on walking	1.5	1.9	2.7	-1.6	-0.8	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.9	0.9	-0.4	0.8
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.1	-1.1	0.3	-1.0
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	2.6	-1.6	1.3	-1.0
Medication: Aspirin	0.2	0.2	0.7	0.0	-0.8	0.1
Supplements: Vitamin C	0.0	0.0	0.1	0.1	0.1	0.3
Knee pain experienced in last month	1.3	2.0	4.2	-1.1	-0.8	-2.0
Hypertension (Self-reported)	0.8	2.2	3.7	-1.9	0.9	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	0.4	-0.2	0.2
Illnesses of father: Heart disease	0.1	0.2	0.3	0.2	-0.6	0.4
Illnesses of siblings: Diabetes	0.5	0.6	1.1	1.0	-0.1	0.9
Smoking status: Previous	0.0	0.0	0.0	-0.2	0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.5	-1.0	-0.7	-1.6
Whole body fat-free mass	0.4	2.2	3.8	-1.6	-0.4	-1.9
Leg fat-free mass (right)	0.4	2.1	4.0	-1.4	-0.3	-2.0
Arm fat percentage (left)	0.1	0.3	0.7	-0.1	-0.8	-0.5
Average weekly red wine intake	13.7	20.2	29.9	5.5	-2.8	4.8
Handedness (chirality/laterality): Left-handed	1.8	2.2	3.4	-1.4	1.8	-1.2
Mood swings	0.2	0.4	0.6	0.7	-0.7	0.4
Loneliness, isolation	0.4	0.5	1.0	0.7	-1.0	0.3
Long-standing illness, disability or infirmity	1.1	1.7	2.2	1.3	-1.5	1.0
Ever had bowel cancer screening	0.2	0.2	0.3	0.2	-0.6	0.4
Diabetes diagnosed by doctor	0.3	0.4	0.7	0.4	0.7	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	-0.4	-0.7	-0.5
Friendships satisfaction	0.9	1.1	1.8	0.6	1.3	1.0
Qualifications: nursing, teaching	0.8	1.2	1.6	1.2	-0.7	1.3
Commuting to job workplace: Walk	1.1	1.2	1.8	1.3	0.4	1.4
Eye problems/disorders: Cataract	1.6	1.8	5.1	0.6	-2.2	0.1
Mouth/teeth dental problems: Mouth ulcers	2.5	3.9	6.8	2.6	-1.3	1.8
Medication for cholesterol	0.3	0.5	0.7	0.5	-0.8	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.5	-0.2	-0.2
Back pain experienced in last month	0.2	0.2	0.7	-0.1	-0.8	-0.0
Mineral and other dietary supplements	0.5	0.6	1.3	0.7	1.1	0.0
Breast cancer (self-reported)	0.1	0.1	0.2	0.5	-0.0	0.2
Asthma (self-reported)	0.9	1.8	4.5	0.7	-2.1	0.7
Osteoporosis (self-reported)	0.4	0.5	0.7	0.8	0.8	0.6
Osteoarthritis (self-reported)	0.5	0.7	1.1	0.9	-1.0	0.2
Medication: Aspirin	0.4	0.5	1.3	-0.1	-1.2	0.2
Medication: Gliclazide	0.8	0.9	1.7	0.7	-0.7	1.3
Illnesses of father: None of the above (group 1)	3.3	4.1	7.1	-2.1	0.9	-2.7
Smoking status: Current	0.3	0.5	0.9	0.9	-0.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.2	0.8	1.1	0.6
Whole body water mass	0.4	2.3	4.0	-1.6	-0.4	-2.0
Leg predicted mass (right)	0.4	2.0	3.8	-1.4	-0.4	-2.0
Arm fat mass (left)	0.2	0.7	1.2	-0.6	-0.7	-1.1
Number of self-reported non-cancer illnesses	0.6	1.0	1.9	1.4	-0.0	1.0
Average weekly champagne plus white wine intake	2.2	3.0	5.3	-1.5	1.2	-2.3
Miserableness	0.3	0.6	1.0	-1.0	-0.1	-0.9
Guilty feelings	0.2	0.2	0.6	-0.2	-0.8	-0.3
Wears glasses or contact lenses	6.6	7.6	8.6	2.8	-2.5	2.9
Ever taken oral contraceptive pill	2.4	2.7	3.9	-2.0	0.5	-1.9
Hearing aid user	0.1	0.1	0.3	0.5	-0.0	-0.1
Mother’s age at death	0.0	0.0	0.1	-0.0	-0.0	-0.2
Financial situation satisfaction	0.4	0.5	1.0	1.0	-0.5	0.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.1	1.0	-1.1	-0.1
Commuting to job workplace: Public transport	0.2	0.2	0.3	-0.6	-0.4	-0.3
Eye problems/disorders: Glaucoma	0.7	0.9	1.4	0.6	-1.2	-0.9
Medication: Blood pressure	1.5	2.9	4.1	-1.6	2.0	-1.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.0	0.5	0.3
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.8	-0.9	-1.4	-0.2
High cholesterol (Self-reported)	0.4	0.7	1.3	0.7	0.4	1.1
Medication: Bendroflumethiazide	1.0	1.5	4.0	-0.3	2.0	-0.7
Medication: Paracetamol	1.2	1.8	2.8	1.7	-1.4	0.8
Medication: Lisinopril	0.2	0.2	0.4	0.3	-0.6	0.5
Medication: Atorvastatin	0.1	0.1	0.3	-0.5	-0.0	0.3
Illnesses of father: High blood pressure	0.5	0.6	1.0	0.6	-0.6	1.0
Alcohol drinker status: Never	1.4	1.7	3.1	-1.8	-0.1	-1.5
Ever smoked	0.2	0.3	0.8	0.1	0.9	0.4
Basal metabolic rate	0.4	2.2	3.9	-1.6	-0.4	-2.0
Leg fat percentage (left)	0.1	0.3	0.7	-0.5	0.2	-0.8
Arm fat-free mass (left)	0.4	2.2	4.0	-1.6	-0.4	-2.0
Number of operations (self-reported)	0.9	1.4	2.9	-0.9	-0.7	-1.7
Average weekly beer plus cider intake	1.7	2.4	4.5	-2.1	0.9	-1.4
Irritability	3.9	6.5	9.5	3.1	-1.4	2.8
Risk taking	0.2	0.3	0.5	0.7	-0.1	0.6
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.2	0.2	-0.4
Fractured/broken bones in last 5 years	0.3	0.4	0.5	0.7	0.2	0.7
Age started oral contraceptive pill	0.9	1.2	1.8	0.7	-1.3	1.1
Diastolic blood pressure, automated reading	1.1	3.4	7.0	-1.8	0.1	-2.6
Ever depressed for a whole week	0.4	0.5	0.8	0.3	0.7	0.9
Unable to work because of sickness or disability	0.4	0.5	0.8	0.8	-0.9	0.3
Commuting to job workplace: Cycle	0.9	1.1	1.4	1.2	1.2	0.7
Myopia	0.6	0.9	1.4	1.2	-0.4	1.0
Vascular/heart problems diagnosed by doctor	0.5	1.5	3.2	1.8	-0.6	0.9
Cholesterol lowering medication	1.1	1.6	2.2	1.5	-1.1	1.1
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	4.9	2.2	-1.1	1.4
Pain experienced in last month	1.4	2.4	7.1	-0.2	2.7	-0.0
Supplements: Calcium	0.3	0.4	0.9	0.3	-0.4	0.9
Basal cell carcinoma (self-reported)	0.2	0.3	0.4	0.6	0.3	0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.4	-0.5	0.6	0.5
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	3.1	1.8	-0.4	1.5
Heart disease (siblings)	0.2	0.2	0.3	-0.4	-0.6	-0.5
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.6	0.0	-0.3
Pack years of smoking	0.2	0.2	0.6	0.8	-0.1	0.3
Impedance of whole body	0.7	3.5	7.2	1.8	-0.1	2.7
Leg fat mass (left)	0.3	1.3	2.6	-1.2	0.1	-1.6
Arm predicted mass (left)	0.5	2.3	4.2	-1.7	-0.3	-2.0