Hub : Genes

CLEC5A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0570 0.0200 1.3e-05 0.031 0.039 0.040 0.039 0.040 9.2e-05 1.6e-05 1.1e-05 1.5e-05 1.1e-05
2 NTR Blood 0.0647 0.0156 1.3e-11 0.022 0.038 0.043 0.041 0.044 8.7e-08 2.5e-12 1.1e-13 3.5e-13 5.2e-14
3 TCGA Brain Lower Grade Glioma 0.0512 0.0369 1.4e-03 0.027 0.019 0.020 NA 0.021 3.8e-04 2.6e-03 2.3e-03 NA 1.7e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.3 0.4 0.7 -0.8 -0.2 -0.7
Bipolar Disorder or Schizophrenia 0.3 0.7 1.2 -1.1 -0.4 -0.8
Depressed Affect (Nagel 2018) 0.1 0.3 0.7 0.3 -0.8 0.1
Depression (Nagel 2018) 0.4 0.5 0.8 -0.9 -0.2 -0.9
Intelligence (Savage-Jansen 2018) 0.5 1.6 2.6 1.6 1.0 1.1
Neuroticism (Nagel 2018) 0.3 0.6 1.1 1.1 -0.4 0.7
Schizophrenia (2018) 0.1 0.3 0.5 -0.7 -0.4 -0.4
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 0.4 -0.4 0.0
Worry (Nagel 2018) 0.2 0.5 0.9 0.7 1.0 0.4
Alzheimer’s Disease (in mother) 1.2 1.4 1.6 1.1 -1.2 1.3
Alzheimer’s Disease (in father) 1.5 1.7 2.1 1.4 -1.2 1.2
Alzheimer’s Disease (including proxy) 3.4 4.9 5.6 2.3 -2.4 2.0
Crohns Disease (2017) 2.5 5.4 7.6 1.9 -2.2 2.7
Irritable Bowel Disease (IBD) 2.1 5.1 7.0 2.0 -2.6 2.1
Ulcerative Colitis (UC) 0.7 1.2 2.3 1.1 -1.5 0.4
Major Depression (MDD) 0.6 0.7 1.3 -1.1 0.3 -0.9
Reaction Time 1.5 2.9 3.8 1.9 -1.2 1.9
Verbal and Numeric Reasoning (VNR) 0.5 1.3 2.8 1.7 0.6 0.8
Breast Cancer 0.4 0.9 1.1 0.8 -1.1 1.0
Ovarian Cancer 0.3 0.4 0.6 0.7 0.3 0.8
Prostate Cancer 0.4 0.6 0.8 -0.9 -0.8 -0.7
Age at First Birth 1.3 1.9 2.2 1.5 -1.4 1.2
Bipolar Disorder (2011) 0.1 0.1 0.3 -0.5 0.2 0.0
Body Mass Index (BMI) (2010) 0.4 0.6 1.2 1.1 -0.3 0.6
Coronary Artery Disease (CAD) 3.4 4.0 9.6 -3.1 1.6 0.0
Crohns Disease (2012) 1.8 2.9 4.2 1.7 -1.2 2.0
Mean Putamen Volume 0.4 0.4 0.9 -0.9 0.3 -0.5
Fasting Glucose 1.1 1.3 2.2 1.2 -0.4 1.5
HbA1C 0.1 0.1 0.1 -0.2 0.4 0.2
HDL Cholesterol 0.1 0.1 0.3 0.3 -0.5 0.1
LDL Cholesterol 0.9 1.4 3.9 0.2 2.0 -0.4
Lupus 1.8 2.8 4.8 -0.9 2.2 -1.7
Neuroticism (2016) 0.1 0.2 0.5 0.7 -0.3 0.3
Primary Biliary Cirrhosis 1.2 1.7 3.2 -1.8 0.2 -1.4
Rheumatoid Arthritis 0.5 0.7 1.9 -1.4 0.4 0.0
Schizophrenia (2014) 0.5 1.2 1.8 -1.3 0.8 -1.1
Triglycerides 0.6 0.9 1.9 -0.5 1.4 -0.8
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.3 -0.1 -0.5 -0.2
Ulcerative Colitis 0.6 0.9 2.5 0.4 -1.6 -0.0
Blood Eosinophil Count 0.3 2.3 2.8 -1.7 1.6 -1.2
Blood Platelet Count 0.1 0.6 0.9 -0.9 0.6 -0.9
Blood Red Count 0.3 3.0 4.2 -2.0 1.4 -1.7
Blood White Count 1.1 7.8 8.1 -2.9 2.8 -2.8
Heel T-Score 0.0 0.2 0.4 -0.6 -0.2 -0.3
BMI 0.6 3.3 7.5 -1.5 0.3 -2.7
Height 0.0 0.0 0.1 0.2 -0.3 0.1
Waist Hip Ratio (WHR) 0.0 0.1 0.2 -0.3 -0.4 -0.1
Systolic Blood Pressure 0.3 1.3 2.8 -1.0 0.3 -1.7
Smoking Status 0.0 0.0 0.0 0.2 -0.2 0.1
Allergy or Eczema 0.5 1.2 2.2 1.5 -0.4 1.2
Cardiovascular Disease 0.5 1.5 2.1 -1.4 0.8 -1.4
Hypothyroidism (self reported) 0.4 1.0 2.4 1.6 0.5 0.6
Respiratory disease 0.9 2.1 3.0 1.7 -1.7 0.7
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.3 0.6 1.5 0.9
Lung FEV1/FVC ratio 0.3 1.7 2.7 1.2 -1.0 1.6
Lung FVC 0.3 1.6 3.0 1.7 0.2 1.3
Neuroticism 0.6 1.4 2.2 1.5 -0.9 1.1
Chronotype (morning person) 0.1 0.3 0.6 0.1 0.4 0.8
Hair Pigment 0.1 2.5 6.3 0.7 -2.5 0.8
Tanning 0.6 7.6 9.1 -2.9 3.0 -2.3
Hand grip strength (left) 0.3 0.8 1.2 -0.5 1.1 -0.9
Number of treatments/medications taken 1.3 2.3 6.3 0.8 -2.5 0.3
Average weekly spirits intake 2.2 2.7 4.7 2.2 -0.5 1.8
Sensitivity / hurt feelings 0.3 0.6 0.8 0.9 0.2 0.9
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.1 -0.4 0.2 -0.4
Hearing difficulty/problems: Yes 0.5 0.7 2.1 1.5 -0.3 0.2
Relative age of first facial hair 0.2 0.4 1.1 -0.3 -1.1 -0.1
Other serious medical condition/disability diagnosed by doctor 2.3 3.0 5.3 2.3 -0.8 1.7
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.3 -1.1 0.4 -0.8
Ever had hysterectomy (womb removed) 1.0 1.1 2.7 0.5 -1.7 0.6
Systolic blood pressure, automated reading 0.4 1.2 2.0 -0.8 -0.9 -1.4
Eye problems/disorders: Diabetes related eye disease 0.9 0.9 1.1 0.8 -1.0 1.0
Angina 0.3 0.4 1.0 0.1 -0.3 1.0
Medication for hormone replacement therapy 0.8 0.9 2.1 -0.7 0.2 -1.5
Vitamin and mineral supplements 0.6 0.8 1.0 0.8 1.0 0.8
Supplements: Zinc 0.5 0.6 0.9 0.8 -0.3 0.9
Medication: Co-codamol 3.5 4.1 8.6 1.4 -2.9 1.3
Medication: Metformin 0.2 0.2 0.4 0.2 0.5 0.6
Diabetes (father) 0.5 0.7 1.3 0.8 -1.1 0.3
Diabetes (mother) 0.9 1.2 1.8 -1.2 0.6 -1.3
Severe depression (siblings) 0.4 0.4 0.9 -0.5 -0.9 -0.3
Pack years adult smoking proportion 0.1 0.1 0.1 0.3 0.3 -0.2
Impedance of leg (right) 0.4 2.0 4.2 1.3 0.1 2.0
Leg fat-free mass (left) 0.4 1.9 3.5 -1.3 -0.7 -1.9
Trunk fat percentage 0.1 0.3 0.9 0.3 -1.0 0.0
Hand grip strength (right) 0.1 0.1 0.3 0.0 0.5 -0.4
Townsend deprivation index at recruitment 0.5 0.7 1.8 -0.1 1.4 -0.5
Current tobacco smoking 0.2 0.4 0.6 0.6 -0.8 0.4
Average weekly fortified wine intake 0.1 0.1 0.1 0.3 -0.0 0.3
Maternal smoking around birth 0.1 0.1 0.3 -0.1 -0.5 0.0
Fed-up feelings 0.5 0.8 2.2 0.0 -1.5 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.8 -0.7 0.2 -0.9
Relative age voice broke 0.2 0.4 1.0 -0.1 1.0 -0.1
Taking other prescription medications 5.0 7.7 8.7 2.9 -2.9 2.4
Age when periods started (menarche) 0.6 1.4 2.3 -1.1 1.5 -0.9
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 0.9 0.5 -0.9 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.8 -0.1 0.9 -0.4
Tinnitus: Yes, but not now, but have in the past 3.0 3.2 5.4 -1.6 2.3 -1.3
Qualifications: CSEs or equivalent 0.0 0.1 0.2 -0.0 -0.4 -0.0
Serious illness, injury or assault to yourself 1.5 1.8 3.7 1.9 -0.9 1.0
High blood pressure 0.5 1.5 3.0 -1.7 0.4 -1.2
Hayfever, allergic rhinitis or eczema 1.3 2.8 4.0 1.8 -1.2 2.0
Multivitamins +/- minerals 2.6 3.3 5.1 -2.1 -0.5 -2.3
Stomach or abdominal pain in last month 0.5 0.6 0.9 0.9 -0.7 0.6
Supplements: Glucosamine 0.2 0.3 0.5 -0.2 -0.7 0.5
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.6 1.3 0.3 1.0
Medication: Atenolol 0.5 0.7 1.3 -1.2 0.3 -0.7
Medication: Levothyroxine sodium 0.2 0.4 0.6 0.8 0.6 0.4
Sitting height 0.0 0.3 0.4 -0.5 0.7 -0.5
Chronic bronchitis/emphysema (father) 0.4 0.4 0.7 0.5 -0.6 0.8
High blood pressure (mother) 0.0 0.0 0.0 0.1 -0.2 -0.1
Body mass index (BMI) 0.3 1.4 3.2 -1.0 -0.2 -1.8
Impedance of leg (left) 0.3 1.7 2.8 1.0 1.1 1.7
Leg predicted mass (left) 0.4 2.0 3.5 -1.4 -0.8 -1.9
Trunk fat mass 0.1 0.5 0.8 -0.6 -0.6 -0.9
Waist circumference 0.2 0.8 1.3 -0.8 -0.8 -1.1
Number of incorrect matches in round 0.5 0.8 1.5 0.9 -1.2 0.3
Past tobacco smoking 0.1 0.1 0.4 -0.0 -0.6 -0.0
Alcohol usually taken with meals 1.4 2.2 5.2 2.3 -0.3 1.2
Nervous feelings 0.1 0.2 0.3 0.5 0.6 0.1
Frequency of tenseness / restlessness in last 2 weeks 1.8 2.8 4.2 1.6 -1.3 2.0
Hearing difficulty/problems with background noise 0.2 0.2 0.4 0.4 0.4 -0.6
Hair/balding pattern: Pattern 2 0.3 0.3 0.6 -0.2 -0.8 -0.6
Had menopause 1.0 1.2 1.6 1.2 -0.8 1.2
Had other major operations 0.2 0.2 0.7 0.2 0.1 -0.8
Forced vital capacity (FVC) 1.1 4.1 8.6 -1.0 2.9 -1.6
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 3.1 -1.1 1.8 -1.3
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 1.3 -0.0 1.1 -0.1
Qualifications: None of the above 1.1 2.4 3.7 -1.9 -1.1 -1.5
Financial difficulties in last 2 years 1.1 1.5 2.4 1.1 -1.5 0.9
Mouth/teeth dental problems 2.1 3.3 5.2 -2.3 1.1 -1.8
Heart attack 0.2 0.3 0.3 -0.5 0.5 0.4
Allergy 1.1 2.6 3.3 -1.4 1.6 -1.8
Pain all over the body in last month 0.3 0.3 0.9 -0.1 -1.0 -0.0
Diabetes (self-reported) 1.1 1.7 3.3 1.3 0.0 1.8
Hayfever/allergic rhinitis (self-reported) 1.9 2.5 3.0 -1.7 1.2 -1.7
Medication: Ramipril 0.7 0.9 1.7 -1.3 0.0 -0.9
Medication: Simvastatin 2.4 3.6 4.7 2.0 -1.5 2.2
Fluid intelligence score 0.5 1.0 1.9 1.4 0.9 0.6
Illnesses of siblings 0.8 1.2 2.9 -0.6 1.7 -0.5
Neuroticism score 0.0 0.1 0.1 0.3 -0.1 0.4
Weight 0.3 1.7 3.3 -1.3 -0.2 -1.8
Impedance of arm (right) 0.7 3.1 6.3 1.7 -0.1 2.5
Arm fat percentage (right) 0.1 0.3 0.5 -0.2 -0.7 -0.6
Trunk fat-free mass 0.5 2.6 4.3 -1.8 -0.2 -2.1
Hip circumference 0.1 0.5 0.9 -0.5 -0.5 -1.0
Time employed in main current job 0.2 0.2 0.4 -0.6 0.2 -0.5
Alcohol intake versus 10 years previously 0.1 0.2 0.3 -0.5 -0.2 -0.4
Father’s age at death 0.2 0.3 0.6 -0.3 0.8 0.4
Worrier / anxious feelings 0.2 0.4 0.6 0.4 0.7 0.8
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.7 2.4 1.5 -0.6 1.5
Falls in the last year 0.4 0.6 1.7 0.4 -1.3 0.1
Hair/balding pattern: Pattern 3 0.1 0.1 0.3 0.2 0.0 0.6
Number of live births 0.5 0.7 0.9 -0.9 0.8 -1.0
Forced expiratory volume in 1-second (FEV1) 1.0 3.5 8.5 -0.6 2.9 -1.2
Pulse rate 0.1 0.2 0.4 0.6 0.6 -0.2
Happiness 0.4 0.5 0.7 0.8 -0.8 0.3
Noisy workplace 4.2 5.2 7.1 1.5 -2.7 2.4
Qualifications: A levels/AS levels or equivalent 3.3 7.4 12.4 3.5 -1.6 2.7
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 0.5 -0.7 0.7 -0.5
Mouth/teeth dental problems: Dentures 0.6 1.0 1.7 1.3 -0.4 1.1
Asthma 0.9 1.8 4.8 0.6 -2.2 0.7
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 1.1 -0.5 -1.1 -0.9
Medication: Cholesterol lowering 0.4 0.7 1.4 0.8 -0.0 1.2
Depression (self-reported) 1.9 2.3 4.3 2.1 0.7 1.4
Medication: Lansoprazole 0.4 0.5 1.1 -0.6 0.2 -1.1
Prospective memory result 1.0 1.3 2.9 0.3 -1.7 0.9
Lung cancer (father) 1.3 1.5 2.4 -1.2 1.5 -0.8
Illnesses of mother 1.2 1.4 2.3 -1.1 1.5 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 3.0 5.9 -0.9 2.4 -1.5
Pulse wave Arterial Stiffness index 0.5 0.6 0.9 -0.9 -0.2 -1.0
Impedance of arm (left) 0.7 3.1 6.3 1.8 -0.2 2.5
Arm fat mass (right) 0.3 1.2 2.4 -1.1 -0.3 -1.6
Trunk predicted mass 0.5 2.6 4.3 -1.8 -0.1 -2.1
Standing height 0.1 0.5 1.2 -1.1 0.2 -0.6
Length of working week for main job 0.2 0.3 0.6 0.2 -0.4 -0.8
Exposure to tobacco smoke at home 0.7 0.8 1.6 0.5 -1.3 0.6
Breastfed as a baby 0.8 1.0 1.4 0.9 1.2 1.0
Tense / ‘highly strung’ 0.1 0.1 0.2 -0.3 0.4 0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 2.0 1.4 0.1 0.7
Hair/balding pattern: Pattern 4 0.0 0.0 0.1 -0.0 0.1 0.4
Birth weight of first child 0.8 1.4 2.0 1.4 -0.9 1.1
Peak expiratory flow (PEF) 1.8 4.1 8.4 -1.1 2.9 -1.7
Pulse wave reflection index 0.4 0.5 0.7 -0.8 0.3 -0.8
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.3 0.3 -0.0 1.1
Loud music exposure frequency 0.6 0.7 0.9 0.7 -1.0 0.8
Qualifications: O levels/GCSEs or equivalent 2.3 3.7 4.8 2.2 -1.5 2.0
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.0 0.8 -0.0 1.0
Blood clot in the leg (DVT) 1.7 2.2 3.6 1.9 -0.7 1.6
Medication: Paracetamol 1.1 1.8 2.9 1.7 -1.2 1.0
Headache pain in last month 0.4 0.8 1.6 0.8 -1.3 0.1
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.3 0.2 0.6 -0.4
Glaucoma (self-reported) 1.0 1.1 2.9 -0.8 -0.0 -1.7
Gout (self-reported) 2.6 3.5 5.8 1.8 -2.4 1.3
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 3.8 2.0 0.2 1.2
Medication: Amlodipine 0.9 1.3 2.8 -1.7 -0.2 -1.1
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.7 0.3 -1.3 0.1
Birth weight 0.3 0.6 1.1 0.4 -0.7 1.1
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.0 0.3 -1.0 1.0
High blood pressure (siblings) 0.3 0.4 0.8 -0.9 -0.2 -0.5
Forced vital capacity (FVC), Best measure 1.3 4.6 8.2 -1.3 2.9 -2.0
Body fat percentage 0.0 0.2 0.4 -0.0 -0.7 -0.3
Leg fat percentage (right) 0.0 0.1 0.2 -0.1 -0.5 -0.4
Arm fat-free mass (right) 0.4 1.9 3.2 -1.5 -0.4 -1.8
Exposure to tobacco smoke outside home 0.5 0.7 1.0 0.9 -1.0 0.6
Comparative body size at age 10 0.0 0.1 0.1 -0.3 -0.3 -0.2
Number of full brothers 0.5 0.6 1.3 -0.5 1.1 -0.5
Worry too long after embarrassment 0.7 1.2 1.9 0.8 -1.4 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.8 2.4 1.6 0.2 0.3
Wheeze or whistling in the chest in last year 0.7 1.2 3.5 -0.4 -1.9 -0.2
Number of children fathered 1.2 1.4 2.5 -1.3 -0.3 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 3.4 3.9 5.9 2.4 -0.7 2.3
Age at first live birth 0.5 1.0 1.4 1.1 -0.4 1.2
Pulse wave peak to peak time 0.4 0.5 0.8 0.8 0.1 0.9
Health satisfaction 1.2 1.5 2.9 -1.1 0.6 -1.7
Shortness of breath walking on level ground 0.6 0.7 1.2 -1.1 0.1 -1.0
Qualifications: College or University degree 0.1 0.4 1.1 1.1 0.2 0.1
Eye problems/disorders: None of the above 2.0 2.3 6.4 -0.6 2.5 -0.3
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.6 0.2 -0.8 -0.0
Emphysema/chronic bronchitis 1.3 1.4 2.3 -1.5 -0.9 -1.1
Medication for pain relief, constipation, heartburn 1.5 2.6 5.6 -1.3 2.4 -0.5
Neck or shoulder pain in last month 1.6 2.3 3.4 1.9 -1.2 1.4
Medication: Blood pressure 0.6 1.1 1.5 -1.2 -0.9 -0.9
Angina (self-reported) 0.3 0.4 1.1 0.1 -0.2 1.0
Migraine (self-reported) 0.2 0.2 0.6 0.4 -0.8 0.0
Medication: Ibuprofen 1.4 1.7 3.7 -0.5 -1.9 -1.1
Medication: Allopurinol 2.6 3.4 4.3 2.1 -2.0 1.4
Medication: Omeprazole 2.0 2.4 3.6 1.9 -1.1 1.5
Medication: Seretide 50 evohaler 0.2 0.2 0.7 -0.1 -0.8 -0.1
Mean time to correctly identify matches 1.7 3.3 4.9 2.0 -0.9 2.2
Heart disease (mother) 0.0 0.0 0.1 0.1 -0.2 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 2.3 0.1 1.5 -1.4
Whole body fat mass 0.2 0.7 1.2 -0.8 -0.5 -1.1
Leg fat mass (right) 0.3 1.0 1.9 -1.0 -0.3 -1.4
Arm predicted mass (right) 0.4 2.0 3.4 -1.5 -0.4 -1.9
Pulse rate, automated reading 0.0 0.1 0.4 -0.1 0.6 -0.1
Alcohol intake frequency. 2.3 5.2 9.7 -3.1 0.6 -2.4
Comparative height size at age 10 0.1 0.3 0.8 0.3 -0.1 0.9
Number of full sisters 2.2 2.7 5.6 -1.4 -0.7 -2.4
Suffer from ‘nerves’ 0.3 0.4 1.1 0.2 1.1 0.2
Overall health rating 0.9 2.0 3.7 -1.6 0.1 -1.9
Chest pain or discomfort 0.3 0.4 1.2 0.0 -1.1 0.1
Had major operations 0.1 0.1 0.2 -0.5 0.1 0.0
Age at last live birth 0.1 0.1 0.2 0.2 0.5 0.4
Family relationship satisfaction 0.4 0.5 1.4 0.1 0.0 1.2
Leg pain on walking 1.5 1.9 2.7 -1.6 -0.8 -1.6
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 0.9 0.9 -0.4 0.8
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.1 -1.1 0.3 -1.0
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 2.6 -1.6 1.3 -1.0
Medication: Aspirin 0.2 0.2 0.7 0.0 -0.8 0.1
Supplements: Vitamin C 0.0 0.0 0.1 0.1 0.1 0.3
Knee pain experienced in last month 1.3 2.0 4.2 -1.1 -0.8 -2.0
Hypertension (Self-reported) 0.8 2.2 3.7 -1.9 0.9 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.1 0.4 -0.2 0.2
Illnesses of father: Heart disease 0.1 0.2 0.3 0.2 -0.6 0.4
Illnesses of siblings: Diabetes 0.5 0.6 1.1 1.0 -0.1 0.9
Smoking status: Previous 0.0 0.0 0.0 -0.2 0.1 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 2.5 -1.0 -0.7 -1.6
Whole body fat-free mass 0.4 2.2 3.8 -1.6 -0.4 -1.9
Leg fat-free mass (right) 0.4 2.1 4.0 -1.4 -0.3 -2.0
Arm fat percentage (left) 0.1 0.3 0.7 -0.1 -0.8 -0.5
Average weekly red wine intake 13.7 20.2 29.9 5.5 -2.8 4.8
Handedness (chirality/laterality): Left-handed 1.8 2.2 3.4 -1.4 1.8 -1.2
Mood swings 0.2 0.4 0.6 0.7 -0.7 0.4
Loneliness, isolation 0.4 0.5 1.0 0.7 -1.0 0.3
Long-standing illness, disability or infirmity 1.1 1.7 2.2 1.3 -1.5 1.0
Ever had bowel cancer screening 0.2 0.2 0.3 0.2 -0.6 0.4
Diabetes diagnosed by doctor 0.3 0.4 0.7 0.4 0.7 0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.5 -0.4 -0.7 -0.5
Friendships satisfaction 0.9 1.1 1.8 0.6 1.3 1.0
Qualifications: nursing, teaching 0.8 1.2 1.6 1.2 -0.7 1.3
Commuting to job workplace: Walk 1.1 1.2 1.8 1.3 0.4 1.4
Eye problems/disorders: Cataract 1.6 1.8 5.1 0.6 -2.2 0.1
Mouth/teeth dental problems: Mouth ulcers 2.5 3.9 6.8 2.6 -1.3 1.8
Medication for cholesterol 0.3 0.5 0.7 0.5 -0.8 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.3 0.5 -0.2 -0.2
Back pain experienced in last month 0.2 0.2 0.7 -0.1 -0.8 -0.0
Mineral and other dietary supplements 0.5 0.6 1.3 0.7 1.1 0.0
Breast cancer (self-reported) 0.1 0.1 0.2 0.5 -0.0 0.2
Asthma (self-reported) 0.9 1.8 4.5 0.7 -2.1 0.7
Osteoporosis (self-reported) 0.4 0.5 0.7 0.8 0.8 0.6
Osteoarthritis (self-reported) 0.5 0.7 1.1 0.9 -1.0 0.2
Medication: Aspirin 0.4 0.5 1.3 -0.1 -1.2 0.2
Medication: Gliclazide 0.8 0.9 1.7 0.7 -0.7 1.3
Illnesses of father: None of the above (group 1) 3.3 4.1 7.1 -2.1 0.9 -2.7
Smoking status: Current 0.3 0.5 0.9 0.9 -0.4 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.2 0.8 1.1 0.6
Whole body water mass 0.4 2.3 4.0 -1.6 -0.4 -2.0
Leg predicted mass (right) 0.4 2.0 3.8 -1.4 -0.4 -2.0
Arm fat mass (left) 0.2 0.7 1.2 -0.6 -0.7 -1.1
Number of self-reported non-cancer illnesses 0.6 1.0 1.9 1.4 -0.0 1.0
Average weekly champagne plus white wine intake 2.2 3.0 5.3 -1.5 1.2 -2.3
Miserableness 0.3 0.6 1.0 -1.0 -0.1 -0.9
Guilty feelings 0.2 0.2 0.6 -0.2 -0.8 -0.3
Wears glasses or contact lenses 6.6 7.6 8.6 2.8 -2.5 2.9
Ever taken oral contraceptive pill 2.4 2.7 3.9 -2.0 0.5 -1.9
Hearing aid user 0.1 0.1 0.3 0.5 -0.0 -0.1
Mother’s age at death 0.0 0.0 0.1 -0.0 -0.0 -0.2
Financial situation satisfaction 0.4 0.5 1.0 1.0 -0.5 0.4
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.1 1.0 -1.1 -0.1
Commuting to job workplace: Public transport 0.2 0.2 0.3 -0.6 -0.4 -0.3
Eye problems/disorders: Glaucoma 0.7 0.9 1.4 0.6 -1.2 -0.9
Medication: Blood pressure 1.5 2.9 4.1 -1.6 2.0 -1.4
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.2 0.0 0.5 0.3
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.8 -0.9 -1.4 -0.2
High cholesterol (Self-reported) 0.4 0.7 1.3 0.7 0.4 1.1
Medication: Bendroflumethiazide 1.0 1.5 4.0 -0.3 2.0 -0.7
Medication: Paracetamol 1.2 1.8 2.8 1.7 -1.4 0.8
Medication: Lisinopril 0.2 0.2 0.4 0.3 -0.6 0.5
Medication: Atorvastatin 0.1 0.1 0.3 -0.5 -0.0 0.3
Illnesses of father: High blood pressure 0.5 0.6 1.0 0.6 -0.6 1.0
Alcohol drinker status: Never 1.4 1.7 3.1 -1.8 -0.1 -1.5
Ever smoked 0.2 0.3 0.8 0.1 0.9 0.4
Basal metabolic rate 0.4 2.2 3.9 -1.6 -0.4 -2.0
Leg fat percentage (left) 0.1 0.3 0.7 -0.5 0.2 -0.8
Arm fat-free mass (left) 0.4 2.2 4.0 -1.6 -0.4 -2.0
Number of operations (self-reported) 0.9 1.4 2.9 -0.9 -0.7 -1.7
Average weekly beer plus cider intake 1.7 2.4 4.5 -2.1 0.9 -1.4
Irritability 3.9 6.5 9.5 3.1 -1.4 2.8
Risk taking 0.2 0.3 0.5 0.7 -0.1 0.6
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 -0.2 0.2 -0.4
Fractured/broken bones in last 5 years 0.3 0.4 0.5 0.7 0.2 0.7
Age started oral contraceptive pill 0.9 1.2 1.8 0.7 -1.3 1.1
Diastolic blood pressure, automated reading 1.1 3.4 7.0 -1.8 0.1 -2.6
Ever depressed for a whole week 0.4 0.5 0.8 0.3 0.7 0.9
Unable to work because of sickness or disability 0.4 0.5 0.8 0.8 -0.9 0.3
Commuting to job workplace: Cycle 0.9 1.1 1.4 1.2 1.2 0.7
Myopia 0.6 0.9 1.4 1.2 -0.4 1.0
Vascular/heart problems diagnosed by doctor 0.5 1.5 3.2 1.8 -0.6 0.9
Cholesterol lowering medication 1.1 1.6 2.2 1.5 -1.1 1.1
Medication: Omeprazole (e.g. Zanprol) 2.2 2.7 4.9 2.2 -1.1 1.4
Pain experienced in last month 1.4 2.4 7.1 -0.2 2.7 -0.0
Supplements: Calcium 0.3 0.4 0.9 0.3 -0.4 0.9
Basal cell carcinoma (self-reported) 0.2 0.3 0.4 0.6 0.3 0.6
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.4 -0.5 0.6 0.5
Deep venous thrombosis (DVT) (self-reported) 1.5 1.9 3.1 1.8 -0.4 1.5
Heart disease (siblings) 0.2 0.2 0.3 -0.4 -0.6 -0.5
Alcohol drinker status: Previous 0.1 0.1 0.3 -0.6 0.0 -0.3
Pack years of smoking 0.2 0.2 0.6 0.8 -0.1 0.3
Impedance of whole body 0.7 3.5 7.2 1.8 -0.1 2.7
Leg fat mass (left) 0.3 1.3 2.6 -1.2 0.1 -1.6
Arm predicted mass (left) 0.5 2.3 4.2 -1.7 -0.3 -2.0