Hub : Genes

PM20D1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.270 0.0380 0.0e+00 0.412 0.288 0.411 0.404 0.408 4.9e-54 2.7e-35 7.8e-54 9.2e-53 1.7e-53
2 METSIM Adipose 0.255 0.0394 0.0e+00 0.302 0.283 0.297 0.307 0.306 8.1e-46 1.2e-42 5.5e-45 8.4e-47 1.2e-46
3 TCGA Bladder Urothelial Carcinoma 0.218 0.0570 0.0e+00 0.255 0.249 0.264 NA 0.265 1.6e-21 4.7e-21 2.5e-22 NA 1.7e-22
4 TCGA Breast Invasive Carcinoma 0.245 0.0496 0.0e+00 0.366 0.369 0.383 NA 0.388 3.3e-79 5.1e-80 7.9e-84 NA 4.9e-85
5 TCGA Cervical Squamous Cell Carcinoma 0.178 0.0580 1.9e-08 0.193 0.185 0.168 NA 0.179 8.4e-10 1.9e-09 1.2e-08 NA 3.5e-09
6 TCGA Colon Adenocarcinoma 0.258 0.0720 8.8e-11 0.129 0.163 0.164 NA 0.111 6.7e-08 1.1e-09 9.7e-10 NA 5.9e-07
7 TCGA Glioblastoma Multiforme 0.285 0.0940 1.2e-05 0.060 0.180 0.169 NA 0.137 6.7e-03 3.9e-06 8.1e-06 NA 5.9e-05
8 TCGA Head and Neck Squamous Cell Carcinoma 0.188 0.0504 0.0e+00 0.253 0.224 0.243 NA 0.253 3.5e-28 9.3e-25 5.2e-27 NA 3.0e-28
9 TCGA Kidney Renal Clear Cell Carcinoma 0.293 0.0653 0.0e+00 0.350 0.311 0.351 NA 0.348 6.6e-41 1.2e-35 5.1e-41 NA 1.2e-40
10 TCGA Kidney Renal Papillary Cell Carcinoma 0.195 0.0680 3.3e-08 0.188 0.135 0.190 NA 0.182 5.9e-11 4.0e-08 4.5e-11 NA 1.2e-10
11 TCGA Brain Lower Grade Glioma 0.410 0.0691 0.0e+00 0.427 0.418 0.440 NA 0.425 9.2e-53 2.5e-51 9.2e-55 NA 1.9e-52
12 TCGA Lung Adenocarcinoma 0.307 0.0587 0.0e+00 0.390 0.388 0.413 NA 0.409 1.7e-48 3.5e-48 5.1e-52 NA 2.6e-51
13 TCGA Lung Squamous Cell Carcinoma 0.258 0.0594 0.0e+00 0.336 0.305 0.337 NA 0.344 3.1e-39 4.2e-35 1.9e-39 NA 1.9e-40
14 TCGA Ovarian Serous Cystadenocarcinoma 0.124 0.0420 1.4e-07 0.131 0.125 0.110 NA 0.109 3.9e-09 9.1e-09 6.7e-08 NA 7.8e-08
15 TCGA Pancreatic Adenocarcinoma 0.320 0.0780 1.3e-11 0.337 0.261 0.303 NA 0.335 7.5e-15 2.4e-11 3.1e-13 NA 9.7e-15
16 TCGA Pheochromocytoma and Paraganglioma 0.340 0.1030 1.9e-07 0.132 0.179 0.208 NA 0.179 6.6e-06 1.3e-07 9.7e-09 NA 1.3e-07
17 TCGA Prostate Adenocarcinoma 0.161 0.0520 3.9e-16 0.142 0.137 0.155 NA 0.147 1.2e-14 3.4e-14 5.6e-16 NA 3.7e-15
18 TCGA Rectum Adenocarcinoma 0.167 0.0780 7.9e-03 0.016 0.007 -0.012 NA -0.008 1.3e-01 2.2e-01 8.6e-01 NA 5.3e-01
19 TCGA Soft Tissue Sarcoma 0.231 0.0600 1.2e-12 0.244 0.185 0.244 NA 0.244 1.2e-14 3.5e-11 1.2e-14 NA 1.2e-14
20 TCGA Skin Cutaneous Melanoma 0.173 0.0830 6.0e-03 0.109 0.057 0.060 NA 0.074 7.8e-04 1.2e-02 1.1e-02 NA 5.0e-03
21 TCGA Stomach Adenocarcinoma 0.091 0.0360 2.5e-06 0.106 0.077 0.099 NA 0.037 4.3e-08 3.1e-06 1.3e-07 NA 1.0e-03
22 TCGA Testicular Germ Cell Tumors 0.415 0.1020 1.6e-11 0.337 0.279 0.327 NA 0.343 1.1e-12 2.1e-10 2.8e-12 NA 6.9e-13
23 TCGA Thyroid Carcinoma 0.259 0.0550 0.0e+00 0.398 0.380 0.399 NA 0.407 3.0e-41 5.3e-39 2.5e-41 NA 2.0e-42
24 TCGA Uterine Corpus Endometrial Carcinoma 0.191 0.0870 7.7e-04 0.091 0.103 0.105 NA 0.115 1.7e-03 8.2e-04 7.5e-04 NA 4.2e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
Bipolar Disorder (2018) 2.2 3.4 6.9 2.2 -1.7 -1.6 -1.8 -1.7 -1.4 -0.8 -1.9 -2.0 -2.0 -2.4 -2.0 -1.8 -1.8 -2.0 -0.8 -1.9 -1.9 -2.2 -2.3 -0.9 -2.6 -2.1 -1.6
Bipolar Disorder or Schizophrenia 1.8 4.4 7.7 2.4 -1.8 -1.7 -2.1 -2.6 -1.5 -1.2 -1.9 -2.2 -2.1 -2.7 -2.1 -2.0 -2.2 -2.1 -1.6 -2.2 -2.4 -2.2 -2.4 -1.1 -2.8 -2.3 -1.8
Depressed Affect (Nagel 2018) 2.8 5.8 12.7 2.3 -1.7 -2.5 -2.5 -2.0 -2.3 -2.9 -2.2 -2.0 -2.4 -2.4 -2.3 -2.1 -3.4 -2.6 -1.4 -2.1 -3.6 -2.2 -2.4 -1.6 -2.6 -2.3 -2.9
Depression (Nagel 2018) 0.2 0.3 2.4 -0.2 0.6 -0.1 -0.1 0.3 -0.7 -1.6 0.2 0.2 0.1 -0.1 -0.0 0.2 -1.4 -0.1 0.1 0.2 -1.4 0.3 0.1 0.2 -0.2 0.2 -0.6
Intelligence (Savage-Jansen 2018) 1.2 3.6 7.5 -2.1 1.6 1.6 2.0 1.5 1.8 1.7 1.7 2.0 1.9 1.8 2.0 1.7 2.4 2.0 1.1 1.6 2.5 1.9 2.2 0.8 2.7 2.0 1.9
Neuroticism (Nagel 2018) 2.5 5.9 11.1 2.3 -1.8 -2.6 -2.5 -1.9 -2.5 -2.5 -2.3 -2.3 -2.5 -2.6 -2.6 -2.2 -3.3 -2.7 -1.4 -2.3 -3.1 -2.4 -2.4 -1.7 -2.7 -2.3 -2.8
Schizophrenia (2018) 0.7 1.5 3.6 1.3 -1.0 -0.9 -1.3 -1.9 -0.8 -1.0 -1.0 -1.3 -1.1 -1.5 -1.1 -1.1 -1.4 -1.1 -1.4 -1.3 -1.5 -1.2 -1.3 -0.7 -1.5 -1.2 -1.0
Schizophrenia vs Biploar Disorder 0.7 0.9 1.6 -1.3 1.2 1.0 1.1 0.8 0.9 0.2 1.1 0.9 1.1 1.1 1.0 1.0 0.7 1.0 0.6 0.8 0.5 1.1 1.2 0.6 1.2 1.1 0.8
Worry (Nagel 2018) 3.0 6.2 9.7 2.7 -2.0 -2.8 -2.5 -2.1 -2.3 -1.8 -2.5 -2.3 -2.7 -2.8 -2.8 -2.2 -3.1 -3.1 -1.2 -2.2 -2.9 -2.5 -2.7 -1.3 -3.1 -2.5 -2.6
Alzheimer’s Disease (in mother) 0.9 1.0 1.7 1.0 -1.2 -0.9 -0.9 -0.9 -1.0 -0.1 -1.1 -1.3 -1.1 -1.2 -0.9 -1.2 -0.4 -1.1 -1.3 -1.1 -0.3 -1.3 -1.2 -1.2 -0.5 -1.1 -0.8
Alzheimer’s Disease (in father) 3.4 3.7 5.4 2.1 -1.8 -2.1 -1.9 -2.2 -0.6 -0.7 -2.0 -1.7 -2.1 -1.9 -2.2 -1.9 -1.8 -2.2 -1.6 -2.0 -2.3 -2.2 -2.0 -1.6 -2.1 -2.0 -2.0
Alzheimer’s Disease (including proxy) 1.7 2.4 3.8 1.7 -1.7 -1.7 -1.5 -1.8 -1.0 -0.1 -1.7 -1.6 -1.8 -1.8 -1.7 -1.7 -0.8 -1.9 -0.9 -1.6 -1.1 -2.0 -1.8 -1.4 -1.5 -1.7 -1.5
Crohns Disease (2017) 1.4 3.0 4.2 2.0 -1.8 -1.8 -1.8 -1.3 -1.7 -1.1 -1.7 -2.0 -1.8 -1.8 -1.8 -1.7 -1.8 -1.9 -1.2 -1.8 -1.7 -1.7 -1.8 -1.3 -2.0 -1.7 -2.1
Irritable Bowel Disease (IBD) 3.0 7.1 9.8 3.1 -2.5 -2.8 -2.6 -2.1 -2.9 -1.7 -2.8 -3.0 -2.8 -3.0 -2.9 -2.6 -2.4 -2.9 -1.6 -3.0 -2.2 -2.8 -2.8 -2.1 -3.0 -2.7 -3.1
Ulcerative Colitis (UC) 4.2 7.9 11.2 3.3 -2.6 -3.1 -2.7 -2.5 -2.9 -1.4 -3.1 -3.1 -3.1 -3.2 -3.1 -2.8 -2.0 -3.2 -1.7 -3.1 -1.8 -3.1 -3.0 -2.3 -3.0 -2.9 -3.1
Major Depression (MDD) 1.7 2.0 4.5 1.4 -1.0 -1.5 -1.3 -2.0 -0.9 -1.5 -1.3 -1.2 -1.3 -1.5 -1.2 -1.4 -1.5 -1.3 -2.1 -1.7 -1.5 -1.1 -1.1 -1.7 -0.7 -1.3 -1.6
Reaction Time 13.1 25.0 31.0 5.1 -4.7 -5.3 -5.2 -4.1 -5.0 -3.4 -5.3 -5.6 -5.2 -5.0 -5.2 -5.3 -5.2 -5.0 -4.6 -5.5 -4.3 -5.3 -5.2 -5.2 -4.7 -5.2 -4.9
Verbal and Numeric Reasoning (VNR) 1.4 3.5 5.5 -2.0 1.8 1.7 2.0 1.2 1.8 1.5 1.8 2.1 1.9 1.9 1.9 1.9 2.2 1.9 1.2 1.8 1.9 2.1 2.1 1.3 2.3 2.0 1.7
Breast Cancer 0.6 1.3 2.0 1.4 -1.1 -1.3 -1.1 -0.6 -1.2 -0.9 -1.3 -1.4 -1.3 -1.0 -1.2 -1.3 -0.6 -1.2 -0.8 -1.1 -1.1 -1.3 -1.2 -1.3 -1.1 -1.2 -1.2
Ovarian Cancer 0.2 0.3 2.0 0.0 0.3 -0.5 -0.4 -0.3 -0.7 -1.4 -0.3 -0.0 -0.2 0.1 -0.5 -0.3 -1.0 -0.1 -0.1 -0.5 -1.1 -0.1 -0.1 -0.8 0.0 -0.1 -0.2
Prostate Cancer 14.6 20.6 23.7 -4.6 4.7 4.9 4.8 4.6 4.1 4.1 4.7 4.4 4.8 4.3 4.7 4.6 4.6 4.8 4.3 4.5 4.1 4.4 4.6 4.3 4.3 4.7 4.8
Age at First Birth 0.2 0.3 1.2 0.4 -0.4 -0.4 -0.6 -0.6 0.0 -0.5 -0.5 -0.6 -0.5 -0.0 -0.4 -0.8 -0.3 -0.3 -0.7 -0.7 -0.6 -0.6 -0.5 -1.1 -0.3 -0.5 0.1
Bipolar Disorder (2011) 3.9 3.8 7.1 0.0 0.0 -1.9 -2.2 -2.3 -1.4 -0.7 -2.1 -2.3 -2.1 -2.5 -2.2 -2.1 -1.9 -2.1 -1.6 -2.1 -1.6 -2.3 -2.3 -1.4 -2.7 -2.3 -1.8
Body Mass Index (BMI) (2010) 8.7 12.0 15.4 -3.5 3.4 3.7 3.5 3.9 2.7 3.1 3.6 3.2 3.6 3.4 3.6 3.6 3.2 3.6 3.4 3.7 3.5 3.4 3.5 3.4 3.2 3.5 3.3
Coronary Artery Disease (CAD) 3.1 3.7 7.1 -1.9 2.3 1.8 2.0 1.7 2.7 0.7 2.1 2.0 2.0 2.4 1.8 2.1 1.4 1.9 0.9 1.9 1.0 2.3 2.4 1.6 1.9 2.2 1.6
Crohns Disease (2012) 1.8 3.0 4.2 2.0 -1.6 -1.9 -1.7 -1.4 -1.7 -1.2 -1.8 -1.7 -1.8 -1.6 -1.8 -1.7 -1.8 -1.8 -1.1 -1.8 -1.8 -1.8 -1.7 -1.5 -1.7 -1.7 -2.0
Mean Putamen Volume 1.1 1.2 4.3 0.8 -1.0 -1.1 -1.1 -2.1 -1.1 -1.6 -0.8 -1.1 -0.9 -1.1 -1.4 -0.9 -0.9 -0.9 -1.4 -1.4 -0.9 -0.8 -0.8 -1.0 -1.1 -0.8 -0.7
Fasting Glucose 0.8 1.0 2.1 -1.1 1.5 1.3 0.7 0.0 1.0 -0.2 1.3 1.2 1.3 0.9 1.2 1.1 0.5 1.2 1.1 0.7 -0.2 1.2 1.1 1.0 0.6 1.2 0.8
HbA1C 4.7 5.2 7.2 -2.6 2.2 2.3 2.3 2.5 2.1 2.0 2.2 2.5 2.3 2.4 2.4 2.2 1.9 2.5 1.6 2.3 2.5 2.2 2.5 1.7 2.7 2.3 2.6
HDL Cholesterol 5.1 8.5 11.1 2.8 -2.9 -3.2 -2.8 -2.7 -2.9 -2.4 -3.1 -2.8 -3.1 -3.0 -3.3 -3.1 -2.7 -3.2 -2.7 -3.3 -2.6 -3.1 -2.9 -3.0 -2.4 -3.0 -2.8
LDL Cholesterol 0.2 0.2 0.6 -0.5 0.3 0.8 0.3 0.5 -0.2 -0.3 0.4 0.4 0.6 0.3 0.8 0.3 0.5 0.8 0.5 0.6 0.6 0.4 0.3 0.4 0.5 0.3 0.7
Lupus 1.3 2.0 3.4 1.5 -1.0 -1.8 -1.2 -1.3 -1.4 -0.1 -1.7 -1.4 -1.7 -1.7 -1.7 -1.5 -0.8 -1.8 -1.2 -1.5 -0.6 -1.7 -1.6 -1.2 -1.1 -1.5 -1.4
Neuroticism (2016) 0.8 1.1 4.3 0.9 -0.6 -0.9 -1.1 -0.5 -0.7 -1.5 -0.9 -1.0 -0.9 -0.6 -1.0 -0.9 -1.8 -1.0 -0.3 -0.8 -2.1 -0.9 -1.0 -0.7 -1.4 -1.0 -1.0
Primary Biliary Cirrhosis 3.7 5.3 7.3 -2.1 2.3 2.4 2.4 2.3 2.6 2.4 2.3 2.7 2.2 2.3 2.5 2.4 1.8 2.1 2.2 2.5 1.7 2.3 2.1 2.6 2.1 2.1 2.6
Rheumatoid Arthritis 0.7 1.0 2.3 1.4 -0.8 -1.2 -0.8 0.0 -0.5 0.0 -1.2 -1.0 -1.3 -1.2 -1.1 -1.0 -0.9 -1.5 -0.8 -0.7 -0.9 -1.2 -1.2 -0.7 -0.9 -1.1 -1.0
Schizophrenia (2014) 1.0 2.3 4.5 1.8 -1.1 -1.3 -1.5 -2.1 -0.8 -1.1 -1.3 -1.5 -1.4 -1.8 -1.5 -1.4 -1.7 -1.5 -1.2 -1.6 -2.0 -1.5 -1.7 -0.8 -2.1 -1.5 -1.2
Triglycerides 0.2 0.3 0.9 -0.8 0.6 0.6 0.2 -0.1 -0.1 -0.2 0.6 0.5 0.8 0.8 0.7 0.5 0.0 0.9 0.4 0.3 0.5 0.8 0.7 0.2 0.6 0.6 0.4
Type 2 Diabetes (T2D) (2012) 4.1 4.7 7.5 -2.0 2.5 1.8 2.3 2.1 1.9 2.7 2.2 1.9 2.1 2.1 1.9 2.5 2.4 1.8 2.5 2.2 2.4 2.1 2.3 2.5 1.5 2.3 1.9
Ulcerative Colitis 2.4 3.5 5.2 2.3 -1.6 -2.0 -1.9 -1.6 -2.0 -1.2 -2.0 -2.2 -1.9 -1.9 -2.1 -1.9 -1.2 -1.9 -1.1 -2.2 -1.2 -2.1 -2.0 -1.7 -2.0 -1.9 -2.0
Blood Eosinophil Count 0.8 6.4 13.8 -2.1 2.9 2.7 2.4 2.2 2.5 1.8 2.6 2.0 2.6 2.6 2.5 2.7 2.8 2.5 3.7 3.0 2.0 2.4 2.3 3.2 0.9 2.5 2.7
Blood Platelet Count 0.2 2.7 6.3 -2.0 1.1 1.4 1.8 1.1 0.9 0.6 1.5 2.5 1.5 1.3 1.8 1.8 0.5 1.4 1.8 1.8 1.0 2.2 1.7 1.9 1.9 1.6 2.1
Blood Red Count 0.0 0.3 2.0 -0.4 -0.7 0.1 0.4 1.1 0.1 0.7 -0.0 0.1 0.2 0.5 0.5 0.1 0.6 0.3 -0.4 0.4 1.4 0.3 0.3 -0.2 1.1 0.2 0.2
Blood White Count 0.1 0.7 5.7 0.7 0.0 -0.0 -0.7 -1.1 0.9 -2.0 -0.0 0.1 -0.2 0.3 -0.2 -0.2 -1.0 -0.4 0.4 0.2 -2.4 -0.1 -0.6 0.5 -1.5 -0.4 -0.2
Heel T-Score 0.1 1.2 2.5 -1.4 1.2 1.1 1.2 0.5 0.3 0.1 1.2 1.4 1.2 1.0 1.3 1.2 0.7 1.1 0.8 0.9 0.5 1.4 1.3 0.9 1.6 1.3 0.8
BMI 3.6 20.9 26.2 -4.8 5.1 4.6 4.7 3.5 4.4 3.2 5.0 5.1 4.9 4.7 4.9 5.0 4.3 4.7 3.9 4.5 3.5 5.0 5.1 4.4 4.6 5.1 4.0
Height 2.7 52.2 83.4 -8.8 7.0 8.2 7.1 6.5 5.3 4.3 7.8 6.9 8.4 7.8 7.7 6.9 6.5 9.1 4.4 6.4 6.9 7.7 8.1 4.3 8.5 7.8 8.0
Waist Hip Ratio (WHR) 0.0 0.2 1.4 -0.0 -0.6 -0.0 -0.2 -0.0 -0.3 -1.0 0.0 0.1 -0.1 -0.1 -0.0 -0.1 -0.9 -0.1 0.2 0.0 -1.2 0.0 -0.1 0.0 -0.1 -0.1 -0.4
Systolic Blood Pressure 0.3 1.7 3.5 1.9 -1.1 -1.3 -1.2 -0.7 -0.5 -0.2 -1.5 -1.2 -1.6 -1.6 -1.4 -1.4 -1.1 -1.8 -0.9 -0.9 -1.1 -1.6 -1.8 -0.5 -1.7 -1.7 -0.9
Smoking Status 1.3 3.1 5.0 2.0 -1.7 -1.7 -1.8 -1.8 -1.0 -1.7 -1.7 -1.7 -1.7 -1.6 -1.9 -1.8 -1.7 -1.6 -1.7 -1.9 -2.2 -1.9 -1.8 -1.7 -1.9 -1.7 -1.8
Allergy or Eczema 0.4 1.1 2.5 -1.3 0.7 1.2 1.0 0.8 0.7 1.1 1.1 0.9 1.2 0.9 1.2 0.9 0.8 1.4 -0.2 0.5 1.2 1.1 1.2 0.2 1.6 1.1 1.4
Cardiovascular Disease 1.9 6.4 9.1 3.0 -2.0 -2.7 -2.7 -2.4 -1.8 -2.1 -2.6 -2.0 -2.8 -2.6 -2.5 -2.5 -3.0 -3.0 -2.0 -2.1 -2.9 -2.4 -2.9 -1.5 -2.9 -2.8 -2.6
Hypothyroidism (self reported) 0.4 0.9 3.0 0.3 -0.6 -0.8 -1.0 -0.6 -1.4 -0.6 -1.0 -1.0 -0.7 -1.0 -0.8 -1.1 -1.3 -0.4 -1.5 -1.5 -0.3 -1.0 -0.7 -1.7 0.0 -0.9 -0.4
Respiratory disease 0.2 0.4 1.0 -0.7 0.7 0.8 0.6 0.3 0.6 0.4 0.7 0.6 0.8 0.6 0.8 0.5 0.6 1.0 0.2 0.3 0.6 0.7 0.8 0.1 0.8 0.7 0.7
Type 2 Diabetes (T2D) (2018) 2.1 3.9 6.6 -2.4 2.4 2.4 1.7 0.2 2.5 1.2 2.5 1.8 2.5 1.9 1.9 1.9 1.5 2.6 -1.0 1.2 1.5 2.3 2.4 0.9 2.3 2.3 1.5
Lung FEV1/FVC ratio 5.6 28.4 46.0 -5.2 5.4 5.8 5.2 4.2 6.8 5.0 5.7 5.5 5.6 5.5 5.7 5.5 5.4 5.4 4.0 5.7 4.3 5.2 5.3 5.3 4.7 5.4 5.5
Lung FVC 1.1 5.8 13.0 2.8 -2.1 -2.9 -2.0 -0.8 -3.6 -0.9 -2.8 -2.6 -2.8 -3.1 -2.8 -2.2 -2.3 -3.0 -0.7 -2.1 -0.8 -2.6 -2.5 -1.4 -2.4 -2.6 -2.7
Neuroticism 3.5 8.5 15.8 3.0 -2.2 -3.0 -3.0 -2.1 -2.4 -3.2 -2.7 -2.8 -3.0 -2.7 -3.2 -2.6 -3.8 -3.4 -1.8 -2.3 -4.0 -2.9 -3.0 -1.8 -3.6 -2.8 -3.4
Chronotype (morning person) 0.5 1.1 2.2 -1.1 1.0 1.1 1.0 1.5 0.9 1.1 1.0 1.0 1.0 0.9 1.1 1.0 0.7 1.1 1.1 1.2 0.9 0.9 1.0 1.0 0.9 1.0 1.2
Hair Pigment 0.8 21.7 29.2 5.2 -4.7 -5.0 -4.6 -3.7 -4.5 -3.2 -5.2 -4.5 -5.3 -5.1 -4.8 -4.8 -4.5 -5.3 -3.2 -4.4 -4.4 -5.1 -5.4 -3.5 -4.8 -5.3 -4.2
Tanning 0.0 0.3 0.7 0.4 -0.8 -0.5 -0.5 -0.7 0.2 -0.7 -0.6 -0.4 -0.5 -0.2 -0.5 -0.7 -0.5 -0.4 -0.4 -0.6 -0.8 -0.7 -0.5 -0.8 -0.4 -0.6 -0.1
Hand grip strength (left) 15.4 40.5 52.9 -6.8 6.1 7.1 6.5 6.2 5.6 4.8 6.8 6.2 7.0 6.6 7.0 6.3 6.3 7.3 5.0 6.1 5.7 6.5 6.8 5.0 6.8 6.7 6.7
Number of treatments/medications taken 5.9 10.6 14.0 3.4 -2.8 -3.5 -3.3 -3.3 -3.1 -2.9 -3.4 -3.0 -3.5 -3.2 -3.3 -3.2 -3.7 -3.5 -3.0 -3.4 -3.2 -3.0 -3.3 -2.9 -3.0 -3.3 -3.5
Average weekly spirits intake 2.0 2.4 6.2 -1.1 1.1 1.7 1.6 1.3 2.5 2.2 1.6 1.8 1.3 0.9 1.4 1.7 1.6 1.1 1.4 1.8 1.1 1.4 1.1 2.5 0.7 1.3 1.7
Sensitivity / hurt feelings 0.9 1.5 2.4 1.3 -0.8 -1.5 -1.1 -0.2 -1.5 -1.5 -1.4 -1.3 -1.4 -0.9 -1.4 -1.1 -1.5 -1.4 -0.2 -1.1 -1.3 -1.2 -1.1 -1.0 -1.2 -1.1 -1.5
Frequency of depressed mood in last 2 weeks 1.0 1.3 4.1 1.0 -0.5 -1.1 -1.2 -0.4 -1.4 -2.0 -1.0 -1.1 -1.0 -0.8 -1.3 -0.9 -1.7 -1.1 -0.3 -0.9 -1.9 -0.9 -1.0 -0.8 -1.6 -0.9 -1.3
Hearing difficulty/problems: Yes 3.4 5.1 6.6 -2.5 2.3 2.3 2.3 2.3 1.9 1.9 2.6 2.4 2.4 2.2 2.1 2.5 2.0 2.2 1.7 2.5 2.3 2.4 2.6 2.2 2.2 2.5 1.8
Relative age of first facial hair 1.0 2.0 3.7 1.5 -0.9 -1.7 -1.4 -1.8 -1.3 -1.5 -1.4 -1.3 -1.5 -1.5 -1.7 -1.2 -1.1 -1.6 0.1 -1.4 -1.5 -1.4 -1.3 -0.9 -1.9 -1.3 -1.5
Other serious medical condition/disability diagnosed by doctor 3.9 5.1 7.5 2.4 -2.2 -2.7 -2.2 -2.3 -2.7 -0.7 -2.6 -2.2 -2.6 -2.7 -2.5 -2.2 -2.2 -2.6 -1.0 -2.5 -1.1 -2.3 -2.3 -1.7 -2.2 -2.4 -2.4
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.8 0.2 0.3 0.0 0.5 1.3 0.2 0.6 -0.1 0.4 -0.1 0.3 0.1 0.3 0.3 -0.2 1.2 0.7 0.4 0.1 -0.1 0.9 -0.1 -0.0 0.6
Ever had hysterectomy (womb removed) 0.1 0.1 0.3 -0.0 0.2 -0.3 0.1 -0.5 0.5 0.5 -0.1 0.5 -0.1 0.1 -0.0 0.1 0.1 -0.2 0.4 -0.1 0.1 0.1 0.1 0.1 0.1 0.0 -0.0
Systolic blood pressure, automated reading 0.7 1.9 3.2 1.6 -1.1 -1.3 -1.5 -1.1 -0.8 -1.1 -1.4 -1.4 -1.5 -1.3 -1.5 -1.5 -1.4 -1.5 -1.4 -0.9 -1.4 -1.5 -1.7 -0.9 -1.8 -1.6 -1.0
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 6.0 -0.1 -0.5 -0.1 -0.2 -0.7 -0.1 -0.2 -0.1 -0.3 -0.1 -0.3 -0.0 -0.3 -0.4 0.1 -2.4 -0.5 0.1 0.0 0.0 -0.9 0.6 -0.1 -0.4
Angina 0.4 0.5 1.6 0.8 -0.2 -0.8 -0.7 -0.5 -1.0 -0.7 -0.5 -0.8 -0.7 -0.8 -0.7 -0.4 -1.3 -0.8 -0.7 -0.6 -0.9 -0.4 -0.5 -0.1 -1.0 -0.5 -1.0
Medication for hormone replacement therapy 0.3 0.3 1.1 0.6 -0.6 -0.8 -0.4 -0.3 -1.1 0.0 -0.7 -0.5 -0.7 -0.7 -0.6 -0.4 -0.6 -0.8 -0.2 -0.4 -0.0 -0.5 -0.6 -0.1 -0.5 -0.6 -0.5
Vitamin and mineral supplements 6.8 9.2 12.2 -3.4 3.5 3.1 3.1 3.0 2.4 2.0 3.3 3.1 3.3 3.1 3.1 3.2 2.8 3.2 2.7 2.9 2.6 3.4 3.3 2.7 3.1 3.3 2.6
Supplements: Zinc 0.2 0.2 1.3 -0.2 0.0 0.5 0.5 0.1 -0.2 0.7 0.2 0.1 0.2 -0.1 0.3 0.2 0.8 0.2 1.1 0.1 0.5 -0.0 0.1 0.4 0.2 0.2 0.3
Medication: Co-codamol 2.0 2.3 4.9 1.4 -1.1 -1.6 -1.6 -2.2 -1.7 -1.4 -1.4 -1.4 -1.5 -1.8 -1.6 -1.4 -1.4 -1.5 -0.4 -1.8 -1.5 -1.5 -1.4 -1.2 -1.7 -1.4 -1.5
Medication: Metformin 1.4 2.0 3.6 -1.7 1.6 1.4 1.3 0.1 1.7 0.9 1.6 1.6 1.6 1.5 1.5 1.4 1.2 1.7 -0.5 0.9 1.3 1.8 1.8 0.6 1.9 1.6 1.1
Diabetes (father) 0.2 0.2 0.7 0.2 -0.6 -0.5 -0.3 -0.3 -0.8 0.1 -0.5 -0.4 -0.5 -0.8 -0.4 -0.4 -0.3 -0.5 -0.0 -0.5 0.2 -0.4 -0.3 -0.5 0.0 -0.4 -0.6
Diabetes (mother) 0.1 0.1 0.6 -0.6 0.2 0.5 0.2 0.7 -0.1 -0.4 0.4 -0.1 0.4 0.5 0.4 0.1 -0.1 0.5 -0.3 0.1 0.1 0.2 0.4 -0.3 0.6 0.4 0.3
Severe depression (siblings) 7.3 8.2 11.1 3.0 -2.5 -2.8 -3.1 -2.8 -2.4 -2.3 -2.9 -2.9 -3.0 -2.8 -3.1 -3.0 -3.0 -2.9 -2.1 -2.9 -3.1 -3.1 -3.2 -2.4 -3.3 -3.0 -2.7
Pack years adult smoking proportion 0.1 0.2 1.2 -0.4 0.6 0.3 -0.0 0.2 0.1 -1.1 0.5 0.3 0.4 0.5 0.3 0.4 -0.5 0.4 0.5 0.5 -0.6 0.6 0.5 0.4 -0.2 0.4 -0.1
Impedance of leg (right) 4.1 19.7 25.7 5.0 -5.0 -4.8 -4.5 -3.2 -3.4 -3.0 -4.8 -4.3 -5.0 -4.6 -4.8 -4.7 -4.3 -5.1 -4.1 -4.1 -4.0 -4.9 -4.9 -3.8 -4.3 -4.9 -4.2
Leg fat-free mass (left) 7.5 39.5 52.4 -7.0 6.7 6.8 6.3 4.8 5.3 4.2 6.8 6.5 7.0 6.7 6.8 6.5 6.1 7.2 5.4 5.8 5.5 6.8 7.0 5.0 6.6 6.9 6.2
Trunk fat percentage 0.3 1.1 2.5 -1.0 1.3 0.8 0.8 0.5 0.9 -0.1 1.2 1.6 1.0 1.2 1.1 1.3 0.0 0.8 1.4 1.1 -0.2 1.4 1.2 1.2 0.8 1.2 0.3
Hand grip strength (right) 17.7 48.0 63.2 -7.6 6.7 7.6 7.1 6.9 6.2 5.0 7.4 6.9 7.7 7.2 7.5 6.9 6.5 8.0 5.2 6.7 5.9 7.2 7.5 5.5 7.4 7.4 7.3
Townsend deprivation index at recruitment 2.0 2.8 4.8 2.0 -1.2 -2.2 -1.8 -1.4 -0.5 -1.4 -1.9 -1.2 -2.0 -1.4 -1.6 -1.6 -1.8 -2.2 -1.7 -1.2 -1.9 -1.6 -1.6 -1.4 -1.5 -1.8 -2.1
Current tobacco smoking 0.3 0.4 1.7 0.6 -0.5 -0.4 -0.6 0.3 -0.6 -1.1 -0.4 -0.6 -0.5 -0.4 -0.8 -0.5 -1.0 -0.6 -0.2 -0.3 -1.3 -0.6 -0.7 -0.1 -1.0 -0.6 -0.7
Average weekly fortified wine intake 2.7 3.2 4.9 2.0 -2.1 -2.0 -1.7 -1.1 -1.8 -1.4 -2.1 -1.6 -2.1 -1.7 -1.8 -1.9 -1.7 -2.1 -0.9 -1.5 -1.8 -1.9 -2.2 -1.2 -1.8 -2.1 -1.4
Maternal smoking around birth 1.2 1.8 3.1 1.5 -1.0 -1.6 -1.4 -1.2 -1.4 -1.7 -1.4 -1.4 -1.5 -0.9 -1.3 -1.2 -1.2 -1.5 -0.5 -1.1 -1.4 -1.1 -1.3 -1.0 -1.7 -1.3 -1.8
Fed-up feelings 0.6 1.1 2.9 0.9 -0.6 -1.2 -1.1 -1.0 -0.6 -1.5 -0.9 -0.7 -1.0 -0.7 -1.1 -0.9 -1.6 -1.2 -0.7 -0.8 -1.7 -0.8 -0.8 -0.8 -1.1 -0.9 -1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 2.1 -0.2 0.9 0.2 0.3 1.0 -0.5 -0.4 0.3 0.5 0.2 -0.0 0.2 0.5 -0.4 0.1 1.4 0.7 -0.4 0.4 0.2 1.0 -0.2 0.3 0.3
Relative age voice broke 0.3 0.5 2.5 0.8 -0.2 -0.6 -0.6 -1.1 0.2 -0.8 -0.4 -0.2 -0.6 -0.6 -0.4 -0.4 -0.7 -0.7 0.5 -0.5 -1.6 -0.4 -0.6 -0.0 -1.1 -0.5 -0.7
Taking other prescription medications 2.1 3.3 5.4 1.6 -1.5 -1.9 -2.0 -2.3 -1.6 -1.3 -1.8 -1.7 -1.7 -2.1 -1.9 -1.8 -2.1 -1.7 -1.7 -2.3 -1.4 -1.6 -1.6 -1.8 -1.8 -1.7 -2.0
Age when periods started (menarche) 5.4 13.0 17.4 4.1 -3.7 -3.7 -3.5 -3.1 -3.1 -2.2 -3.7 -3.6 -3.9 -4.0 -3.7 -3.5 -3.8 -4.2 -3.7 -3.3 -3.2 -3.6 -3.9 -2.6 -3.6 -3.9 -4.1
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 3.9 -0.6 0.9 0.8 1.1 0.8 1.7 1.7 0.8 1.5 0.7 0.6 1.0 1.1 0.9 0.4 2.0 1.2 0.5 0.9 0.6 1.9 0.3 0.7 1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.3 -0.6 1.2 0.9 0.4 0.2 0.6 -0.8 0.8 0.9 0.8 0.9 1.0 0.5 0.0 1.0 0.3 0.6 -0.6 0.8 0.6 0.1 0.7 0.6 0.8
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 2.4 -0.4 0.8 0.7 1.0 0.7 0.8 1.6 0.6 0.5 0.6 0.5 0.6 0.7 1.2 0.6 0.7 0.4 1.0 0.6 0.6 0.9 0.6 0.6 1.1
Qualifications: CSEs or equivalent 0.5 0.6 1.3 1.0 -1.0 -1.1 -0.8 -0.5 -0.1 -0.5 -0.9 -0.8 -1.0 -0.8 -0.8 -0.8 -0.4 -1.1 -0.4 -0.5 -0.4 -1.0 -0.8 -0.5 -1.1 -0.8 -0.8
Serious illness, injury or assault to yourself 0.9 1.1 3.1 0.8 -0.9 -1.1 -1.1 -1.4 -1.7 -1.3 -0.8 -0.6 -0.9 -1.5 -1.0 -0.7 -1.8 -1.0 -0.3 -0.8 -0.9 -0.6 -0.8 -0.3 -1.2 -0.9 -1.0
High blood pressure 1.4 3.9 6.7 2.2 -1.3 -2.0 -2.1 -1.4 -1.6 -1.9 -2.0 -1.7 -2.1 -2.0 -2.2 -2.0 -2.6 -2.2 -1.5 -1.6 -2.4 -2.0 -2.2 -1.3 -2.4 -2.1 -1.8
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.3 -0.9 0.4 0.7 0.6 0.1 0.3 0.7 0.6 0.3 0.8 0.4 0.6 0.4 0.7 1.0 -0.5 -0.0 1.1 0.7 0.8 -0.3 1.1 0.7 1.1
Multivitamins +/- minerals 10.7 13.6 18.0 4.0 -4.2 -4.0 -3.8 -3.4 -3.0 -2.7 -4.1 -3.7 -4.1 -3.7 -3.9 -3.9 -3.6 -4.0 -2.8 -3.5 -3.2 -4.1 -4.0 -3.3 -3.8 -4.1 -3.1
Stomach or abdominal pain in last month 1.0 1.2 3.9 1.6 -0.6 -1.2 -1.0 -0.5 -0.1 -0.2 -1.0 -0.9 -1.3 -1.0 -1.3 -0.8 -1.0 -1.6 0.0 -0.6 -1.5 -1.2 -1.3 -0.0 -2.0 -1.1 -1.3
Supplements: Glucosamine 6.3 8.2 16.3 2.6 -2.6 -2.6 -3.0 -2.2 -4.0 -3.5 -2.8 -2.9 -2.7 -3.0 -2.7 -2.9 -3.4 -2.5 -1.6 -2.8 -3.1 -2.9 -2.9 -2.6 -2.7 -2.9 -2.7
Diverticular disease/diverticulitis (self-reported) 2.6 3.1 5.5 2.0 -1.8 -2.1 -1.6 -1.6 -1.1 -1.2 -1.8 -1.6 -2.0 -1.8 -1.9 -1.6 -1.5 -2.2 -1.5 -1.6 -1.8 -1.6 -1.7 -1.4 -1.8 -1.7 -2.3
Medication: Atenolol 1.4 1.7 3.1 1.6 -1.0 -1.5 -1.3 0.3 -0.9 -1.5 -1.5 -1.4 -1.5 -0.7 -1.5 -1.4 -1.3 -1.6 -0.4 -0.8 -1.7 -1.5 -1.5 -1.1 -1.6 -1.4 -0.8
Medication: Levothyroxine sodium 2.6 4.3 7.8 1.7 -2.1 -2.0 -2.2 -2.0 -2.7 -1.5 -2.3 -2.4 -2.0 -2.3 -2.0 -2.4 -2.0 -1.5 -2.1 -2.6 -0.8 -2.3 -2.0 -2.8 -1.4 -2.1 -1.7
Sitting height 9.4 67.0 87.6 -9.3 8.3 8.8 8.4 6.8 6.8 6.1 8.7 8.2 9.0 8.4 8.5 8.2 8.4 9.4 6.0 7.6 7.9 8.6 8.9 6.2 8.8 8.9 8.7
Chronic bronchitis/emphysema (father) 0.4 0.4 1.4 -0.5 1.2 0.5 0.5 1.2 0.9 0.4 0.7 0.5 0.6 0.8 0.5 0.7 0.4 0.4 0.2 0.9 0.5 0.6 0.6 0.7 0.2 0.6 0.5
High blood pressure (mother) 1.7 2.4 7.1 1.8 -1.3 -1.6 -1.7 -1.2 -0.5 -1.8 -1.6 -1.2 -1.6 -1.0 -1.5 -1.6 -1.9 -1.6 -0.9 -1.4 -2.7 -1.6 -1.7 -1.4 -1.8 -1.6 -1.4
Body mass index (BMI) 1.3 5.7 9.1 -2.4 3.0 2.3 2.3 1.4 2.4 1.1 2.6 2.9 2.5 2.6 2.7 2.7 1.9 2.4 2.7 2.4 1.2 2.8 2.6 2.5 2.1 2.6 1.7
Impedance of leg (left) 3.8 18.3 23.3 4.8 -4.8 -4.6 -4.4 -3.0 -3.5 -2.9 -4.6 -4.3 -4.7 -4.4 -4.7 -4.5 -4.2 -4.8 -3.9 -3.9 -3.7 -4.7 -4.7 -3.7 -4.3 -4.7 -4.0
Leg predicted mass (left) 7.5 39.7 52.6 -7.0 6.7 6.8 6.3 4.8 5.3 4.2 6.8 6.5 7.0 6.7 6.8 6.5 6.1 7.2 5.4 5.8 5.5 6.8 7.0 5.0 6.6 6.9 6.2
Trunk fat mass 1.8 7.6 10.9 -3.1 3.2 2.8 2.7 1.9 2.4 1.2 3.1 3.3 3.1 3.1 3.0 3.0 1.8 3.0 2.7 2.7 1.6 3.3 3.2 2.4 2.8 3.2 2.1
Waist circumference 1.6 5.8 8.1 -2.8 2.8 2.4 2.3 1.6 2.0 0.9 2.6 2.8 2.7 2.7 2.7 2.6 1.8 2.7 2.6 2.3 1.4 2.8 2.8 2.0 2.5 2.8 1.9
Number of incorrect matches in round 7.5 12.4 19.0 4.0 -3.4 -3.7 -3.5 -3.2 -2.8 -3.2 -3.6 -3.4 -3.8 -3.9 -3.7 -3.3 -3.6 -4.2 -2.2 -2.9 -3.8 -3.7 -3.9 -1.9 -4.4 -3.8 -3.8
Past tobacco smoking 0.7 1.3 3.1 -1.4 1.2 1.3 1.1 1.8 0.5 0.3 1.2 1.1 1.3 1.2 1.4 1.1 0.5 1.3 0.6 1.2 0.6 1.3 1.1 1.0 1.3 1.1 1.1
Alcohol usually taken with meals 2.2 3.5 5.4 1.9 -2.3 -2.1 -1.8 -1.8 -1.4 -0.6 -2.1 -2.1 -2.0 -1.9 -2.2 -2.1 -1.1 -2.0 -1.5 -2.2 -1.0 -2.2 -1.9 -2.1 -1.6 -1.9 -1.7
Nervous feelings 3.3 6.2 10.1 2.5 -2.3 -2.9 -2.4 -1.6 -3.2 -1.1 -2.7 -2.7 -2.8 -3.0 -3.1 -2.3 -2.5 -3.0 -1.2 -2.3 -1.3 -2.7 -2.7 -1.6 -2.8 -2.6 -2.5
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.8 3.4 1.4 -0.4 -1.6 -1.3 -1.1 -1.5 -1.8 -1.3 -1.2 -1.4 -1.2 -1.7 -1.1 -1.7 -1.6 -0.5 -0.9 -1.7 -1.2 -1.2 -0.8 -1.7 -1.2 -1.2
Hearing difficulty/problems with background noise 10.4 16.6 21.0 -4.4 4.3 4.4 4.1 3.3 4.1 3.2 4.6 4.0 4.6 4.4 4.3 4.3 3.8 4.5 2.5 3.8 3.4 4.4 4.5 3.4 4.2 4.5 3.9
Hair/balding pattern: Pattern 2 1.3 1.6 2.8 -1.6 1.1 1.4 1.3 0.5 1.0 0.6 1.4 1.2 1.5 1.3 1.2 1.3 1.7 1.6 0.9 0.7 1.5 1.4 1.7 0.6 1.6 1.5 1.1
Had menopause 0.2 0.2 0.8 0.2 -0.2 -0.5 -0.5 -0.3 -0.6 -0.5 -0.4 -0.2 -0.5 -0.5 -0.7 -0.3 -0.9 -0.5 0.2 -0.2 -0.7 -0.5 -0.5 -0.0 -0.8 -0.5 -0.2
Had other major operations 0.1 0.2 1.2 -0.1 -0.0 0.2 0.2 1.1 -0.4 0.3 0.0 0.4 0.1 0.1 0.3 0.2 -0.5 0.2 1.1 0.1 -0.1 0.2 0.0 0.5 0.1 0.1 0.3
Forced vital capacity (FVC) 1.1 4.2 8.9 -1.9 1.9 1.9 2.3 3.0 1.3 2.6 1.8 1.9 1.9 1.7 2.0 2.0 1.9 1.9 2.1 2.1 2.5 1.9 2.1 1.8 2.2 2.0 2.1
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.7 5.0 -1.6 2.2 1.8 1.6 1.3 2.0 0.9 1.8 1.9 1.8 1.9 2.0 1.6 1.5 1.8 1.1 1.6 0.8 1.8 1.8 1.2 1.7 1.8 1.5
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.8 0.6 -0.3 -0.3 -0.5 -0.3 -0.5 -0.4 -0.5 -0.3 -0.4 -0.6 -0.3 -0.4 -0.9 -0.3 -0.1 -0.3 -0.7 -0.4 -0.5 -0.2 -0.7 -0.6 -0.4
Qualifications: None of the above 0.9 2.0 5.6 1.7 -0.6 -1.6 -1.2 -1.0 -1.5 -0.6 -1.3 -1.3 -1.6 -1.7 -1.7 -0.9 -1.2 -2.1 0.2 -1.0 -1.3 -1.3 -1.5 0.1 -2.4 -1.3 -2.0
Financial difficulties in last 2 years 0.0 0.1 0.3 -0.2 0.1 0.0 0.1 -0.2 0.5 0.5 0.0 0.4 0.1 0.3 0.3 0.1 0.0 0.2 0.1 -0.2 0.2 0.2 0.2 -0.1 0.4 0.1 0.4
Mouth/teeth dental problems 3.0 4.6 7.2 -2.4 1.5 2.4 2.4 2.7 1.4 1.9 2.2 1.8 2.2 2.1 2.1 2.0 2.5 2.3 0.8 2.3 2.6 2.0 2.2 1.6 2.7 2.2 2.4
Heart attack 0.7 0.9 2.8 0.9 -0.1 -1.0 -1.0 -1.0 -0.7 -1.0 -0.7 -1.1 -0.9 -0.9 -1.2 -0.7 -0.9 -1.0 -0.5 -0.8 -1.1 -0.8 -0.8 -0.5 -1.7 -0.7 -1.0
Allergy 0.4 0.9 2.0 1.1 -0.7 -0.9 -0.9 -0.4 -0.6 -0.9 -0.9 -0.7 -1.1 -0.8 -1.0 -0.8 -1.1 -1.3 -0.1 -0.5 -1.4 -1.1 -1.1 -0.3 -1.1 -1.0 -1.4
Pain all over the body in last month 0.4 0.4 1.5 -1.1 0.4 0.7 0.4 0.5 -0.8 -0.3 0.6 0.3 0.7 0.5 0.2 0.4 0.4 1.0 0.4 0.2 0.9 0.4 0.6 -0.0 0.7 0.6 1.2
Diabetes (self-reported) 1.0 1.6 4.5 -1.4 1.6 1.3 1.0 -0.0 2.1 1.2 1.4 1.2 1.4 1.4 1.1 1.1 0.8 1.5 -0.9 0.6 0.9 1.5 1.5 0.3 1.4 1.4 1.1
Hayfever/allergic rhinitis (self-reported) 0.6 0.9 4.6 -0.8 0.6 0.9 0.8 1.2 -0.2 1.5 0.7 0.3 0.8 0.1 0.5 0.7 1.2 1.0 1.1 0.5 2.1 0.5 0.7 0.7 0.5 0.7 1.4
Medication: Ramipril 0.8 1.0 2.4 1.3 -0.6 -1.3 -1.0 -0.5 -0.1 -1.1 -1.0 -0.6 -1.2 -0.5 -1.2 -0.8 -1.2 -1.6 -0.5 -0.2 -1.4 -0.9 -1.1 -0.3 -1.4 -1.1 -1.4
Medication: Simvastatin 1.1 1.7 2.9 1.3 -1.0 -1.4 -1.3 -1.6 -1.2 -1.2 -1.4 -1.1 -1.3 -1.0 -1.3 -1.3 -1.5 -1.2 -1.7 -1.5 -1.0 -1.0 -1.1 -1.6 -0.7 -1.2 -1.3
Fluid intelligence score 1.4 2.9 5.5 -1.9 1.4 1.7 1.8 1.1 1.5 1.3 1.7 2.2 1.8 1.6 1.8 1.7 1.7 1.9 1.2 1.5 1.6 1.8 1.9 1.2 2.4 1.8 1.7
Illnesses of siblings 0.1 0.1 0.6 -0.4 -0.3 0.1 0.2 -0.5 -0.4 -0.2 0.0 0.1 0.2 -0.0 0.2 0.0 0.6 0.3 -0.3 -0.3 0.8 0.2 0.3 -0.4 0.7 0.2 0.2
Neuroticism score 4.4 9.1 15.2 3.2 -2.4 -3.3 -3.1 -1.8 -2.9 -2.9 -3.0 -3.0 -3.2 -2.7 -3.3 -2.8 -3.9 -3.5 -1.8 -2.5 -3.7 -3.0 -3.1 -2.1 -3.5 -3.0 -3.3
Weight 5.0 24.5 30.7 -5.5 5.4 5.2 5.0 3.7 4.4 3.2 5.3 5.3 5.5 5.3 5.4 5.1 4.6 5.5 4.5 4.7 4.0 5.4 5.5 4.0 5.1 5.4 4.7
Impedance of arm (right) 3.9 18.1 23.3 4.6 -4.8 -4.4 -4.4 -3.3 -3.7 -3.3 -4.5 -4.3 -4.6 -4.3 -4.6 -4.5 -4.4 -4.6 -3.6 -4.0 -3.9 -4.6 -4.7 -3.6 -4.4 -4.7 -3.9
Arm fat percentage (right) 0.3 1.1 2.4 -0.9 1.5 0.8 0.8 0.2 1.2 -0.3 1.1 1.6 1.0 1.2 1.2 1.2 0.1 0.8 1.5 1.2 -0.4 1.3 1.1 1.3 0.6 1.1 0.2
Trunk fat-free mass 6.9 39.6 56.2 -7.2 6.5 6.8 6.3 4.8 5.2 4.4 6.7 6.2 7.1 6.6 6.8 6.3 6.4 7.5 4.7 5.6 5.9 6.7 7.0 4.4 7.0 6.9 6.4
Hip circumference 2.1 8.8 11.9 -3.3 3.5 3.1 2.9 2.0 2.9 1.7 3.2 3.3 3.3 3.4 3.3 3.1 2.7 3.4 2.5 2.8 2.2 3.3 3.4 2.2 3.1 3.3 2.7
Time employed in main current job 0.4 0.4 1.4 0.2 -0.6 -0.6 -0.6 -1.2 -0.8 -0.8 -0.6 -0.6 -0.6 -0.7 -0.8 -0.6 -0.6 -0.6 -0.8 -0.6 -0.7 -0.6 -0.6 -0.7 -0.5 -0.6 -0.3
Alcohol intake versus 10 years previously 0.1 0.2 1.1 -0.2 0.1 0.4 0.4 0.1 0.4 0.5 0.4 0.3 0.3 0.2 0.3 0.5 0.6 0.2 0.8 0.5 0.5 0.3 0.2 1.1 -0.3 0.3 0.0
Father’s age at death 0.1 0.1 0.7 -0.2 -0.6 -0.4 0.1 0.5 -0.7 0.2 -0.3 0.1 -0.3 -0.2 0.0 -0.1 -0.3 -0.4 -0.1 0.0 0.2 -0.1 -0.0 -0.3 0.8 -0.1 -0.3
Worrier / anxious feelings 2.7 5.2 10.9 2.4 -1.8 -2.3 -2.4 -2.0 -1.7 -2.4 -2.3 -1.8 -2.4 -2.1 -2.3 -2.1 -3.1 -2.6 -1.0 -2.0 -3.3 -2.1 -2.5 -1.3 -2.8 -2.4 -2.0
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 2.1 -0.8 1.4 0.9 0.4 0.1 0.2 -0.7 0.9 0.6 0.9 0.7 0.5 0.8 -0.1 1.0 1.3 0.4 -0.4 0.8 0.7 0.8 -0.1 0.8 0.7
Falls in the last year 3.6 4.9 6.6 -2.6 2.0 2.5 2.3 2.2 1.1 2.0 2.3 2.2 2.4 1.8 2.5 2.3 1.9 2.5 2.0 2.0 2.3 2.4 2.3 2.1 2.4 2.3 2.5
Hair/balding pattern: Pattern 3 4.3 6.3 11.4 2.4 -2.5 -2.4 -2.7 -2.2 -2.7 -3.4 -2.3 -2.6 -2.5 -2.5 -2.5 -2.4 -2.9 -2.5 -2.0 -1.9 -2.8 -2.4 -2.6 -1.9 -2.8 -2.5 -2.5
Number of live births 2.2 3.1 5.3 1.7 -1.6 -1.6 -2.0 -1.9 -1.5 -2.3 -1.6 -1.5 -1.6 -1.7 -2.0 -1.6 -2.1 -1.6 -0.9 -1.6 -2.1 -1.7 -1.7 -1.1 -2.3 -1.7 -2.1
Forced expiratory volume in 1-second (FEV1) 3.6 12.1 15.5 -3.2 3.2 3.5 3.7 3.9 3.3 3.9 3.3 3.5 3.4 3.1 3.7 3.5 3.3 3.4 3.2 3.7 3.7 3.3 3.4 3.4 3.5 3.3 3.6
Pulse rate 2.0 3.3 5.4 -1.6 2.2 1.7 2.0 1.6 1.7 2.3 1.9 1.9 1.8 1.5 1.7 2.1 1.8 1.6 2.0 1.6 1.5 1.9 1.9 2.1 1.4 2.0 1.2
Happiness 0.4 0.4 0.9 0.9 -0.6 -0.6 -0.6 0.1 -0.6 -0.8 -0.7 -0.6 -0.7 -0.5 -0.6 -0.7 -0.8 -0.7 -0.3 -0.4 -0.9 -0.7 -0.8 -0.6 -0.6 -0.7 -0.5
Noisy workplace 0.4 0.5 1.5 0.6 -0.6 -0.6 -0.6 -0.2 -1.1 -1.1 -0.4 -0.7 -0.6 -0.7 -0.7 -0.4 -0.8 -0.8 -0.2 -0.4 -0.8 -0.5 -0.6 0.1 -1.0 -0.5 -1.2
Qualifications: A levels/AS levels or equivalent 0.7 1.5 2.5 -1.6 1.0 1.4 1.1 1.0 1.1 0.6 1.3 0.9 1.4 1.6 1.2 1.0 1.4 1.6 0.1 1.2 1.4 1.2 1.4 0.3 1.5 1.4 1.4
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.6 3.2 1.3 -1.8 -1.4 -1.1 -0.9 -1.8 0.0 -1.5 -1.6 -1.3 -1.5 -1.1 -1.4 -0.7 -1.1 -1.7 -1.2 0.2 -1.3 -1.2 -1.5 -0.7 -1.3 -0.9
Mouth/teeth dental problems: Dentures 0.4 0.6 2.3 0.7 -0.1 -0.6 -0.7 -0.6 -0.6 -1.5 -0.5 -0.1 -0.6 -0.6 -0.5 -0.4 -1.2 -0.8 0.7 -0.3 -1.5 -0.4 -0.7 0.3 -1.3 -0.7 -0.8
Asthma 0.2 0.4 1.1 0.8 -0.5 -0.4 -0.7 -1.1 -0.1 -0.5 -0.6 -0.9 -0.4 -0.5 -0.5 -0.8 0.1 -0.2 -0.6 -0.8 -0.4 -0.7 -0.6 -1.0 -0.8 -0.6 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 2.6 0.8 -0.7 -1.3 -1.0 -0.9 -1.4 -1.0 -1.0 -1.1 -1.0 -0.8 -1.2 -0.9 -1.0 -1.0 -1.0 -1.3 -0.7 -0.8 -0.7 -1.2 -0.7 -0.7 -1.6
Medication: Cholesterol lowering 0.8 1.2 3.7 1.2 -0.6 -1.4 -1.0 -1.1 -1.4 -0.9 -1.0 -0.8 -1.1 -1.1 -1.1 -0.8 -1.7 -1.3 -1.3 -1.1 -0.9 -0.6 -0.8 -0.6 -0.8 -0.9 -1.9
Depression (self-reported) 3.9 4.7 8.1 1.9 -1.9 -2.2 -2.1 -2.3 -2.8 -2.4 -2.0 -2.0 -2.0 -2.4 -2.1 -1.9 -2.8 -2.0 -1.9 -2.3 -2.4 -1.8 -1.9 -1.9 -1.9 -1.9 -2.5
Medication: Lansoprazole 0.0 0.0 0.3 -0.3 0.2 -0.1 0.0 -0.0 -0.1 0.1 0.0 0.3 0.0 0.1 -0.2 0.1 -0.5 -0.0 0.2 -0.1 0.2 0.1 0.1 0.2 0.0 0.1 0.2
Prospective memory result 0.9 1.1 2.0 1.3 -0.7 -0.9 -1.1 -1.0 -0.8 -1.0 -0.9 -1.3 -1.0 -0.9 -1.1 -1.0 -1.1 -1.1 -0.9 -0.9 -1.3 -1.0 -1.2 -0.7 -1.4 -1.1 -1.1
Lung cancer (father) 0.3 0.4 1.5 -0.5 0.4 0.8 0.4 0.6 0.5 -0.3 0.6 0.7 0.5 0.5 0.6 0.6 0.1 0.5 1.2 0.8 -0.4 0.5 0.3 1.0 0.0 0.4 0.5
Illnesses of mother 1.0 1.3 2.2 -1.4 1.0 1.2 1.1 0.5 0.7 0.6 1.3 1.2 1.3 0.8 1.2 1.2 1.2 1.4 0.2 0.8 1.5 1.4 1.4 0.9 1.4 1.3 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.9 6.1 9.8 -2.2 2.3 2.5 2.6 2.1 2.3 3.1 2.4 2.6 2.4 1.8 2.7 2.5 2.5 2.4 2.7 2.4 2.8 2.3 2.4 2.6 2.5 2.4 2.4
Pulse wave Arterial Stiffness index 2.5 2.9 6.3 1.7 -1.4 -1.5 -1.9 -1.8 -1.1 -1.8 -1.6 -1.6 -1.6 -1.6 -1.6 -1.8 -2.0 -1.5 -2.5 -1.5 -1.9 -1.6 -1.8 -1.6 -1.6 -1.8 -1.4
Impedance of arm (left) 2.8 13.0 18.0 3.9 -4.2 -3.8 -3.8 -2.6 -3.3 -2.6 -3.9 -3.6 -3.9 -3.6 -4.0 -3.8 -3.8 -4.0 -3.0 -3.3 -3.1 -4.0 -4.0 -3.1 -3.7 -4.0 -3.4
Arm fat mass (right) 2.1 8.8 12.0 -3.2 3.5 3.0 2.9 1.9 2.9 1.3 3.3 3.5 3.3 3.3 3.4 3.2 2.3 3.2 3.0 2.9 1.6 3.5 3.3 2.7 2.9 3.3 2.4
Trunk predicted mass 7.1 40.5 57.5 -7.3 6.6 6.9 6.4 4.9 5.2 4.4 6.8 6.2 7.2 6.6 6.9 6.3 6.5 7.6 4.8 5.7 6.0 6.8 7.1 4.5 7.0 7.0 6.5
Standing height 4.0 39.8 57.8 -7.3 5.9 6.9 6.3 5.5 5.0 4.9 6.6 6.1 7.1 6.7 6.5 6.1 6.5 7.6 4.5 5.6 6.5 6.5 6.9 4.0 7.2 6.8 7.0
Length of working week for main job 0.7 0.8 3.2 -0.7 0.4 0.7 1.0 0.5 0.7 1.6 0.7 0.4 0.7 0.4 0.6 0.8 1.8 0.7 0.7 0.6 1.7 0.6 0.8 0.7 0.7 0.8 1.0
Exposure to tobacco smoke at home 0.2 0.2 0.7 0.8 -0.3 -0.6 -0.2 -0.2 0.7 0.3 -0.6 0.1 -0.7 0.2 -0.1 -0.4 -0.4 -0.8 0.1 -0.0 -0.9 -0.3 -0.6 -0.2 -0.2 -0.6 -0.3
Breastfed as a baby 5.0 6.2 8.7 2.8 -2.9 -2.6 -2.5 -2.1 -2.9 -1.2 -2.8 -2.9 -2.7 -2.6 -2.7 -2.7 -1.9 -2.6 -2.3 -2.3 -1.1 -2.8 -2.8 -2.3 -2.4 -2.9 -1.9
Tense / ‘highly strung’ 9.5 15.7 20.0 4.1 -3.6 -4.5 -4.1 -3.4 -3.8 -3.3 -4.2 -4.0 -4.3 -3.9 -4.3 -4.0 -4.2 -4.3 -3.8 -3.8 -3.5 -4.1 -4.0 -3.6 -3.8 -4.1 -4.1
Seen doctor (GP) for nerves, anxiety, tension or depression 7.0 10.6 13.5 3.6 -2.9 -3.6 -3.3 -2.8 -2.9 -2.3 -3.5 -3.2 -3.5 -3.5 -3.5 -3.3 -3.7 -3.6 -2.3 -3.3 -3.2 -3.3 -3.4 -2.7 -3.5 -3.4 -3.2
Hair/balding pattern: Pattern 4 1.0 2.3 7.8 -1.0 1.6 1.1 1.7 1.6 1.8 2.8 1.1 1.7 1.1 1.4 1.7 1.5 1.4 0.9 1.0 1.8 1.6 1.5 1.2 1.6 1.7 1.3 1.3
Birth weight of first child 2.9 5.3 7.4 -2.7 2.3 2.4 2.3 1.9 1.6 1.9 2.4 2.3 2.5 2.3 2.4 2.3 2.1 2.6 0.9 2.1 2.7 2.6 2.6 1.7 2.7 2.5 2.6
Peak expiratory flow (PEF) 23.8 55.2 67.1 -7.1 7.2 7.7 7.6 7.9 8.2 7.5 7.4 7.4 7.4 7.6 7.9 7.2 7.5 7.5 6.1 8.0 7.1 7.1 7.3 6.7 7.2 7.3 8.0
Pulse wave reflection index 8.7 10.7 18.9 3.4 -3.5 -3.4 -3.4 -3.4 -2.0 -3.0 -3.5 -3.3 -3.5 -3.0 -3.2 -3.7 -2.8 -3.3 -4.3 -3.2 -2.7 -3.4 -3.5 -3.6 -2.6 -3.6 -2.6
Ever highly irritable/argumentative for 2 days 0.2 0.2 1.4 -0.0 0.6 0.1 0.2 0.5 -0.1 0.1 0.3 0.3 0.2 0.1 0.1 0.6 -0.1 -0.0 1.1 0.6 -0.0 0.4 0.2 1.2 -0.5 0.2 0.1
Loud music exposure frequency 0.7 0.8 1.6 -1.2 0.7 1.1 0.9 0.4 0.1 0.2 1.1 0.2 1.1 0.8 0.7 0.8 1.3 1.2 0.4 0.3 1.3 0.9 1.1 0.4 0.8 1.1 0.9
Qualifications: O levels/GCSEs or equivalent 2.1 3.4 5.6 -1.9 1.1 2.1 1.8 1.6 1.9 1.3 1.9 1.5 2.1 2.3 2.0 1.6 2.4 2.3 1.0 1.9 2.2 1.8 2.0 0.9 2.1 1.9 1.9
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 3.3 1.0 -0.5 -1.2 -0.9 -1.8 0.1 -0.3 -1.1 -0.9 -1.0 -0.9 -0.9 -1.1 -0.3 -0.9 -0.9 -1.6 -0.8 -0.9 -0.8 -1.6 -0.5 -0.8 -0.8
Blood clot in the leg (DVT) 0.6 0.8 1.5 -1.1 0.5 1.0 0.8 0.6 0.7 0.9 0.8 0.9 0.9 0.8 0.9 0.9 0.9 1.0 1.2 1.0 1.1 0.8 0.7 1.1 0.5 0.7 1.2
Medication: Paracetamol 1.5 2.5 4.9 1.7 -1.5 -1.9 -1.7 -1.4 -1.0 -2.0 -1.5 -1.1 -1.7 -1.2 -1.9 -1.3 -2.1 -2.0 -0.5 -0.9 -2.2 -1.4 -1.5 -0.7 -2.2 -1.5 -1.9
Headache pain in last month 2.9 5.1 8.5 1.9 -1.9 -2.3 -2.3 -2.2 -2.9 -2.8 -2.1 -2.2 -2.1 -2.2 -2.4 -2.1 -2.6 -2.1 -1.6 -2.4 -2.1 -2.1 -2.0 -2.1 -2.1 -2.0 -2.7
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 3.5 -1.0 0.1 1.3 0.9 0.7 1.0 1.4 0.8 0.5 1.0 0.6 1.1 0.5 1.9 1.3 1.1 0.6 1.4 0.3 0.7 0.3 0.9 0.7 1.6
Glaucoma (self-reported) 0.9 1.0 3.9 1.2 -1.0 -0.8 -1.1 -1.4 0.2 -0.5 -0.8 -0.9 -1.0 -1.0 -0.9 -0.8 -0.8 -1.1 -0.3 -0.6 -1.4 -1.0 -1.2 -0.0 -2.0 -1.1 -0.8
Gout (self-reported) 1.6 2.2 4.1 -1.9 1.5 1.7 1.6 0.7 1.0 1.3 1.7 1.4 1.7 0.9 1.5 1.5 1.6 1.8 0.3 0.8 2.0 1.6 1.7 1.1 1.9 1.7 1.4
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 3.8 0.8 -1.1 -1.1 -1.4 -1.2 -1.6 -0.8 -1.3 -1.4 -1.1 -1.5 -1.2 -1.5 -1.4 -0.7 -1.6 -1.8 -0.4 -1.4 -1.1 -2.0 -0.5 -1.2 -0.8
Medication: Amlodipine 0.8 1.1 3.2 0.9 -0.6 -1.0 -1.1 -1.0 -0.6 -0.9 -1.0 -0.8 -0.9 -0.6 -1.0 -1.2 -1.4 -0.8 -1.8 -1.3 -1.0 -0.9 -0.9 -1.6 -0.4 -0.9 -1.1
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.9 -0.3 0.5 0.1 0.4 0.4 -0.1 -0.1 0.2 0.5 0.3 0.6 0.6 0.4 0.2 0.3 0.9 0.3 0.2 0.6 0.4 0.3 0.4 0.4 0.3
Birth weight 5.9 12.9 20.7 -4.3 3.2 4.1 3.5 3.2 2.8 2.4 3.9 3.4 4.1 4.0 3.9 3.4 3.2 4.5 1.6 3.0 3.4 3.8 4.1 1.9 4.5 3.9 4.0
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.6 0.9 -0.4 -0.3 -0.6 0.1 -0.5 -0.2 -0.6 -0.9 -0.6 -0.5 -0.1 -0.5 -0.3 -0.6 0.8 -0.0 -0.3 -0.7 -0.9 0.2 -1.3 -0.8 -0.2
High blood pressure (siblings) 0.6 0.8 4.4 1.1 -0.4 -0.5 -1.0 -0.4 0.4 -0.3 -0.7 -0.6 -0.9 -0.7 -0.8 -0.8 -1.2 -1.0 -0.2 -0.5 -2.1 -1.0 -1.3 -0.0 -1.7 -1.0 -0.7
Forced vital capacity (FVC), Best measure 0.4 1.5 4.1 -1.1 1.0 1.0 1.4 1.4 0.4 2.0 1.0 1.2 1.1 0.5 1.1 1.2 1.3 1.1 1.6 1.1 2.0 1.0 1.2 1.2 1.5 1.1 1.0
Body fat percentage 0.2 0.9 2.3 -0.8 1.3 0.7 0.8 0.3 0.9 -0.3 1.1 1.5 0.9 1.1 1.1 1.2 -0.1 0.7 1.4 1.1 -0.4 1.2 1.1 1.2 0.7 1.1 0.1
Leg fat percentage (right) 0.0 0.2 0.8 0.1 0.5 -0.2 0.0 -0.2 0.3 -0.6 0.1 0.7 -0.0 0.2 0.2 0.3 -0.7 -0.2 0.8 0.4 -0.9 0.3 0.1 0.5 -0.1 0.1 -0.4
Arm fat-free mass (right) 8.3 42.5 57.9 -7.4 6.8 7.0 6.6 5.1 5.3 4.5 7.0 6.6 7.3 6.7 7.0 6.6 6.5 7.6 5.2 5.8 6.0 7.0 7.3 4.8 7.2 7.2 6.5
Exposure to tobacco smoke outside home 0.2 0.3 0.8 0.9 -0.3 -0.7 -0.3 0.1 -0.5 -0.3 -0.7 -0.1 -0.7 -0.4 -0.1 -0.4 -0.9 -0.7 -0.4 -0.2 -0.4 -0.2 -0.4 -0.2 -0.1 -0.6 -0.9
Comparative body size at age 10 12.3 34.1 39.1 -6.0 6.2 6.1 6.1 5.8 5.5 5.1 6.2 5.6 6.1 5.9 5.8 6.1 6.0 5.9 5.1 6.0 5.4 5.9 6.0 5.7 5.2 6.1 6.0
Number of full brothers 0.2 0.2 1.2 -0.3 0.3 0.4 0.0 0.3 1.1 -0.2 0.3 0.2 0.4 0.5 0.2 0.1 0.3 0.5 1.1 0.0 -0.0 0.0 0.3 0.1 -0.2 0.2 0.9
Worry too long after embarrassment 0.1 0.2 0.6 0.6 -0.4 -0.7 -0.4 0.6 -0.3 -0.0 -0.6 -0.6 -0.6 -0.1 -0.5 -0.4 -0.7 -0.7 -0.8 -0.1 -0.4 -0.4 -0.4 -0.5 -0.4 -0.4 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 12.0 15.6 20.1 4.1 -3.4 -4.4 -4.0 -3.6 -4.3 -3.0 -4.3 -4.0 -4.3 -4.5 -4.2 -4.0 -4.0 -4.3 -2.7 -4.0 -3.4 -4.0 -4.1 -3.4 -4.0 -4.1 -4.2
Wheeze or whistling in the chest in last year 0.2 0.3 1.1 -0.3 0.9 0.7 0.1 0.6 0.2 -0.1 0.7 0.1 0.7 0.6 0.1 0.5 0.2 0.7 1.0 0.3 0.1 0.4 0.3 0.8 -0.7 0.5 0.5
Number of children fathered 1.4 1.6 4.8 1.1 -1.1 -1.5 -1.1 -1.0 -2.2 -1.0 -1.4 -1.1 -1.3 -1.5 -1.5 -1.1 -1.5 -1.2 -0.0 -1.6 -0.8 -1.3 -1.1 -1.1 -1.1 -1.2 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.9 0.1 0.1 0.3 0.3 0.3 0.5 0.4 0.2 0.2 0.1 0.0 0.0 0.3 0.1 -0.1 0.7 0.5 -0.1 0.1 -0.1 1.0 -0.4 0.0 0.6
Age at first live birth 0.4 0.7 2.0 -1.1 0.4 1.0 0.8 0.5 0.4 0.8 0.9 0.6 1.0 0.9 0.8 0.6 0.8 1.2 -0.1 0.3 0.8 0.8 1.0 -0.1 1.4 0.9 0.7
Pulse wave peak to peak time 3.7 4.4 7.8 -2.1 1.8 1.9 2.3 2.1 1.4 2.2 2.0 2.0 2.1 2.0 2.0 2.1 2.5 2.0 2.8 1.8 2.4 2.0 2.2 1.8 2.1 2.2 1.9
Health satisfaction 0.3 0.4 2.0 0.3 0.5 0.1 0.5 1.2 0.4 1.4 0.1 0.4 -0.1 -0.1 0.3 0.5 -0.0 -0.4 1.1 0.7 0.3 0.2 -0.1 1.4 -0.3 0.0 -0.2
Shortness of breath walking on level ground 0.3 0.3 2.7 -0.1 0.2 0.4 0.5 0.7 -0.3 1.6 0.2 0.0 0.2 -0.2 0.4 0.4 0.6 0.2 0.8 0.3 1.4 0.2 0.1 0.8 0.1 0.2 0.5
Qualifications: College or University degree 0.6 1.8 6.0 -2.0 0.6 1.3 1.3 0.8 0.5 -0.1 1.5 1.3 1.6 1.5 1.3 1.2 0.9 1.7 -0.7 1.1 1.3 1.6 1.8 0.1 2.4 1.6 1.3
Eye problems/disorders: None of the above 2.6 3.0 6.9 -1.6 2.1 1.5 1.7 2.0 1.3 1.4 1.6 1.8 1.7 1.8 1.5 1.7 1.7 1.7 2.6 1.7 1.5 1.6 1.8 1.4 1.4 1.8 1.6
Mouth/teeth dental problems: Loose teeth 0.1 0.1 1.0 0.4 0.1 -0.3 -0.3 -0.6 0.3 -0.1 -0.2 -0.0 -0.3 -0.2 -0.3 -0.2 -0.6 -0.4 0.2 -0.3 -1.0 -0.2 -0.4 0.1 -0.7 -0.3 -0.1
Emphysema/chronic bronchitis 0.2 0.3 1.5 -0.5 0.5 0.3 0.4 0.6 -0.3 0.7 0.3 0.2 0.5 0.3 0.3 0.4 0.5 0.6 0.6 0.1 1.2 0.5 0.6 0.2 0.4 0.5 0.7
Medication for pain relief, constipation, heartburn 3.9 6.6 10.4 -2.9 2.2 3.2 2.6 2.1 2.4 2.1 2.7 2.4 2.9 2.2 2.9 2.4 3.0 3.2 2.1 2.2 2.4 2.2 2.6 1.9 2.8 2.6 3.1
Neck or shoulder pain in last month 2.1 3.0 5.5 -1.4 2.0 2.0 1.8 2.1 1.3 1.5 2.1 1.5 1.9 1.6 1.7 2.0 1.3 1.6 1.5 2.3 1.1 1.8 1.7 2.4 1.0 1.9 1.5
Medication: Blood pressure 0.9 1.7 3.3 1.4 -0.4 -1.6 -1.2 -0.7 -1.0 -1.8 -1.2 -1.1 -1.4 -0.9 -1.5 -1.0 -1.8 -1.7 -1.7 -0.7 -1.6 -0.8 -1.1 -0.9 -1.3 -1.1 -1.7
Angina (self-reported) 0.5 0.7 1.8 0.9 -0.3 -0.9 -0.7 -0.6 -1.0 -0.7 -0.6 -0.9 -0.8 -0.9 -0.8 -0.5 -1.3 -1.0 -0.4 -0.7 -1.0 -0.5 -0.7 -0.2 -1.2 -0.6 -1.0
Migraine (self-reported) 0.1 0.1 0.4 -0.2 0.5 0.1 0.4 0.5 0.3 0.2 0.4 0.4 0.3 0.6 0.3 0.5 -0.0 0.1 0.3 0.4 0.1 0.6 0.4 0.6 0.2 0.5 -0.2
Medication: Ibuprofen 1.2 1.4 2.7 1.0 -1.1 -1.5 -1.1 -0.9 -1.6 -1.1 -1.3 -1.2 -1.2 -1.0 -1.3 -1.1 -1.2 -1.3 -0.8 -1.3 -0.9 -1.1 -1.0 -1.2 -0.9 -1.1 -1.5
Medication: Allopurinol 0.5 0.7 2.1 -1.0 0.7 1.1 0.7 0.3 0.6 0.6 1.0 0.6 1.1 0.6 0.7 0.7 1.0 1.2 -0.1 0.3 1.4 0.8 1.0 0.3 1.0 0.9 0.8
Medication: Omeprazole 0.1 0.1 0.6 0.1 0.1 -0.1 -0.0 -0.7 0.3 0.8 -0.1 0.1 -0.1 -0.1 -0.0 -0.1 0.0 0.0 -0.2 -0.3 0.3 -0.0 -0.0 -0.2 0.1 -0.1 0.2
Medication: Seretide 50 evohaler 0.1 0.1 0.6 0.1 0.1 -0.3 -0.1 -0.0 -0.7 0.2 -0.3 -0.3 -0.1 -0.2 -0.1 -0.2 0.2 0.0 0.1 -0.5 0.5 -0.2 -0.0 -0.6 0.4 -0.0 -0.3
Mean time to correctly identify matches 18.4 35.1 44.1 6.0 -5.6 -6.2 -6.3 -5.1 -5.8 -4.4 -6.3 -6.6 -6.1 -5.8 -6.3 -6.3 -6.0 -5.8 -5.4 -6.3 -5.0 -6.3 -6.1 -6.2 -5.8 -6.1 -5.8
Heart disease (mother) 0.4 0.5 1.2 0.8 -0.4 -1.0 -0.5 0.4 -0.8 -0.6 -0.7 -0.7 -0.8 -0.1 -0.9 -0.6 -1.0 -1.0 -0.3 -0.3 -0.9 -0.7 -0.6 -0.7 -0.6 -0.6 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.9 0.3 -0.7 -0.6 -0.5 -0.6 -0.7 -0.6 -0.5 -0.5 -0.4 -0.5 -0.6 -0.6 -0.5 -0.4 -1.4 -0.9 -0.3 -0.4 -0.3 -1.0 0.0 -0.4 -0.6
Whole body fat mass 2.1 8.7 12.4 -3.3 3.4 3.0 2.9 2.1 2.6 1.2 3.3 3.5 3.3 3.3 3.3 3.2 2.1 3.2 2.9 2.9 1.7 3.5 3.4 2.6 3.0 3.3 2.4
Leg fat mass (right) 1.8 6.9 10.2 -2.8 3.2 2.6 2.6 1.8 2.4 1.2 2.9 3.2 2.9 2.9 3.0 2.9 1.8 2.8 2.7 2.6 1.4 3.1 3.0 2.4 2.7 2.9 2.2
Arm predicted mass (right) 8.4 43.2 56.9 -7.4 6.9 7.0 6.7 5.2 5.5 4.8 7.0 6.7 7.3 6.8 7.1 6.7 6.6 7.5 5.3 6.0 6.1 7.1 7.3 5.0 7.1 7.2 6.5
Pulse rate, automated reading 5.6 17.9 23.1 -4.6 4.6 4.2 4.5 3.8 3.8 3.7 4.5 4.5 4.5 4.5 4.4 4.5 3.8 4.4 2.8 4.1 3.9 4.7 4.8 3.5 4.8 4.7 3.6
Alcohol intake frequency. 0.2 0.5 1.6 -0.5 1.1 0.5 0.5 0.6 0.7 -0.0 0.6 0.4 0.6 0.9 0.5 0.7 0.9 0.6 1.2 0.7 0.6 0.8 0.7 0.9 -0.2 0.7 0.5
Comparative height size at age 10 7.3 40.3 54.8 -7.3 6.1 6.9 6.5 5.5 4.3 5.2 6.6 5.9 7.0 6.2 6.4 6.3 6.9 7.4 5.1 5.9 7.1 6.5 6.8 4.7 6.8 6.8 7.0
Number of full sisters 0.6 0.7 2.5 -0.6 0.9 0.8 0.7 0.6 1.4 1.6 0.8 0.8 0.6 0.4 0.7 0.9 0.6 0.5 1.0 0.8 0.7 0.5 0.5 1.4 0.1 0.6 0.9
Suffer from ‘nerves’ 0.3 0.5 3.2 0.8 -0.0 -0.7 -0.2 0.3 -0.2 0.3 -0.5 -0.2 -0.7 -0.4 -0.8 0.0 -0.4 -1.1 1.8 0.3 -0.5 -0.5 -0.6 1.1 -1.5 -0.4 -0.4
Overall health rating 0.5 1.0 2.6 1.1 0.0 -1.1 -1.1 -1.2 -1.0 -1.3 -0.8 -0.8 -0.9 -1.1 -1.1 -0.7 -1.2 -1.1 0.1 -0.9 -0.8 -0.8 -0.8 -0.3 -1.6 -0.8 -1.4
Chest pain or discomfort 0.1 0.2 0.7 -0.1 0.5 0.5 -0.3 -0.5 0.6 -0.5 0.5 -0.0 0.5 0.0 0.0 0.2 0.1 0.6 0.4 -0.0 -0.3 0.1 0.1 0.4 -0.8 0.2 0.3
Had major operations 0.4 0.4 2.7 0.6 -0.8 -0.9 -0.3 0.2 -1.6 0.2 -0.8 -0.3 -0.8 -1.0 -0.5 -0.4 -0.6 -0.9 0.0 -0.1 0.7 -0.4 -0.6 0.0 -0.1 -0.7 -0.8
Age at last live birth 0.3 0.4 1.2 -0.9 0.3 0.8 0.5 0.1 -0.1 0.0 0.7 0.1 0.9 0.7 0.5 0.4 0.7 1.1 0.0 0.1 0.8 0.5 0.9 -0.4 0.9 0.8 0.1
Family relationship satisfaction 0.4 0.5 1.6 0.9 -0.7 -0.1 -0.8 -0.3 -0.5 -0.8 -0.4 -0.7 -0.5 -0.8 -0.3 -0.7 -1.1 -0.4 -0.5 -0.5 -1.3 -0.7 -0.9 -0.2 -1.0 -0.8 -0.6
Leg pain on walking 0.1 0.1 0.8 -0.0 0.4 0.3 -0.1 -0.5 -0.0 0.1 0.2 -0.1 0.1 -0.3 -0.0 0.2 -0.5 0.1 0.6 -0.1 -0.4 -0.0 -0.1 0.8 -0.9 -0.0 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 1.9 -0.0 0.8 0.2 0.5 0.8 0.7 0.6 0.3 0.4 0.2 0.5 0.5 0.5 0.5 0.1 1.4 0.5 0.2 0.3 0.3 0.7 0.0 0.4 0.3
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.4 -0.9 0.8 1.1 1.1 0.3 0.7 1.6 1.0 1.3 1.0 0.4 1.3 0.9 0.5 1.1 0.8 0.4 0.7 1.0 0.9 0.7 1.5 0.9 1.0
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.5 -0.8 1.1 0.7 1.0 0.6 1.0 0.3 1.0 0.8 0.8 1.2 0.6 1.0 1.0 0.5 0.5 1.0 0.2 0.9 1.0 0.9 0.6 1.0 0.1
Medication: Aspirin 1.9 2.5 3.9 1.7 -1.1 -1.9 -1.6 -1.2 -1.5 -1.2 -1.8 -1.5 -1.9 -1.4 -1.8 -1.6 -2.0 -2.0 -1.6 -1.4 -1.4 -1.4 -1.7 -1.3 -1.6 -1.7 -1.6
Supplements: Vitamin C 0.2 0.2 0.8 0.8 -0.5 -0.2 -0.2 0.2 0.5 0.4 -0.2 -0.4 -0.5 -0.3 -0.4 -0.2 -0.2 -0.8 -0.4 0.3 -0.7 -0.5 -0.6 0.5 -0.9 -0.5 -0.5
Knee pain experienced in last month 0.5 0.7 1.7 1.0 -0.3 -0.7 -0.7 0.2 -1.0 -0.5 -0.8 -0.6 -0.9 -1.0 -0.7 -0.5 -1.3 -1.1 0.2 -0.2 -0.9 -0.8 -1.1 0.4 -1.3 -1.0 -1.1
Hypertension (Self-reported) 1.2 3.2 5.3 2.0 -1.2 -1.8 -1.9 -1.2 -1.4 -1.8 -1.9 -1.5 -1.9 -1.8 -2.1 -1.8 -2.3 -2.0 -1.4 -1.4 -2.1 -1.8 -2.0 -1.2 -2.2 -2.0 -1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 2.7 1.1 -1.6 -1.3 -1.1 -1.0 -1.6 -0.7 -1.4 -1.1 -1.3 -1.4 -1.1 -1.2 -1.1 -1.2 -0.8 -1.1 -0.3 -1.2 -1.2 -1.0 -0.7 -1.4 -0.9
Illnesses of father: Heart disease 4.2 5.8 8.3 2.6 -2.7 -2.5 -2.6 -2.1 -2.5 -2.1 -2.6 -2.7 -2.5 -2.3 -2.6 -2.4 -2.3 -2.5 -1.5 -2.0 -1.9 -2.5 -2.6 -2.0 -2.9 -2.6 -2.2
Illnesses of siblings: Diabetes 1.6 2.0 3.9 -1.7 1.8 1.7 1.1 1.0 0.7 0.8 1.7 1.4 1.8 1.3 1.5 1.5 0.4 2.0 1.6 1.2 0.8 1.5 1.6 1.2 1.1 1.6 1.4
Smoking status: Previous 0.9 1.4 4.1 1.4 -1.4 -1.3 -1.1 -2.0 -0.7 -0.1 -1.4 -1.2 -1.3 -1.3 -1.2 -1.3 -0.3 -1.2 -0.6 -1.4 -0.3 -1.4 -1.2 -1.3 -1.1 -1.2 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 2.6 -1.5 1.0 1.2 0.8 0.6 0.1 0.1 1.2 0.8 1.4 0.9 1.0 0.9 0.8 1.6 0.9 0.5 0.8 1.0 1.3 0.1 1.2 1.2 1.0
Whole body fat-free mass 7.6 43.6 59.6 -7.5 6.9 7.1 6.7 5.0 5.5 4.5 7.1 6.6 7.4 6.9 7.1 6.7 6.6 7.7 5.2 6.0 6.0 7.1 7.4 4.9 7.1 7.3 6.6
Leg fat-free mass (right) 7.9 42.0 56.4 -7.3 6.9 7.0 6.5 5.0 5.4 4.4 7.0 6.5 7.3 6.8 7.0 6.7 6.3 7.5 5.5 6.0 5.8 7.0 7.2 5.1 6.7 7.2 6.4
Arm fat percentage (left) 0.4 1.7 3.5 -1.2 1.7 1.1 1.1 0.5 1.4 0.1 1.5 1.9 1.3 1.5 1.5 1.6 0.5 1.1 1.9 1.5 0.0 1.7 1.5 1.6 0.9 1.4 0.5
Average weekly red wine intake 1.1 1.7 2.9 1.5 -1.2 -1.5 -1.2 -1.7 -0.7 -0.2 -1.5 -1.1 -1.5 -1.3 -1.3 -1.3 -1.4 -1.6 -1.5 -1.4 -1.1 -1.1 -1.4 -1.0 -1.2 -1.4 -0.9
Handedness (chirality/laterality): Left-handed 0.6 0.8 1.8 1.3 -0.9 -0.7 -0.7 -0.5 -0.4 0.0 -1.1 -0.9 -1.1 -1.0 -0.6 -1.0 -0.6 -1.2 -0.3 -0.5 -0.9 -1.2 -1.3 -0.4 -0.8 -1.2 -0.6
Mood swings 8.8 16.0 23.7 4.3 -3.5 -4.2 -4.1 -3.2 -3.3 -4.1 -4.1 -3.7 -4.3 -3.9 -4.0 -3.9 -4.8 -4.5 -2.7 -3.3 -4.9 -4.0 -4.2 -3.0 -4.3 -4.2 -4.3
Loneliness, isolation 1.3 1.8 4.5 1.4 -0.5 -1.3 -1.4 -1.0 -1.3 -1.7 -1.1 -1.3 -1.2 -1.4 -1.4 -1.1 -1.9 -1.4 -0.2 -1.2 -2.1 -1.3 -1.3 -0.7 -1.9 -1.2 -1.6
Long-standing illness, disability or infirmity 1.4 2.2 5.2 1.2 -0.7 -1.5 -1.6 -2.3 -1.4 -1.0 -1.2 -1.1 -1.2 -1.7 -1.5 -1.3 -2.1 -1.2 -1.6 -2.1 -1.4 -1.1 -1.1 -1.5 -1.3 -1.2 -1.9
Ever had bowel cancer screening 0.3 0.4 1.0 0.4 -0.3 -0.4 -0.7 -0.4 -0.8 -0.2 -0.5 -0.8 -0.5 -0.7 -0.9 -0.6 -0.8 -0.3 -0.4 -0.9 -0.2 -0.6 -0.6 -0.6 -1.0 -0.6 -0.2
Diabetes diagnosed by doctor 1.6 2.6 4.6 -1.9 1.7 1.7 1.4 0.2 2.1 1.4 1.8 1.6 1.9 1.6 1.6 1.4 1.2 2.0 -1.1 0.9 1.6 2.0 1.9 0.5 2.1 1.8 1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.9 0.5 -0.8 -0.6 -0.5 -0.4 -1.0 -0.8 -0.8 -0.6 -0.7 -0.6 -0.7 -0.8 -0.6 -0.5 -0.2 -0.9 -0.5 -0.8 -0.6 -1.0 -0.1 -0.7 -0.4
Friendships satisfaction 0.1 0.1 0.4 0.6 -0.3 -0.1 -0.3 0.1 -0.1 0.2 -0.3 -0.3 -0.4 -0.5 -0.1 -0.3 -0.4 -0.4 0.2 0.1 -0.2 -0.4 -0.6 0.3 -0.6 -0.5 0.0
Qualifications: nursing, teaching 0.4 0.6 3.6 0.1 -1.0 -0.6 -0.5 -0.3 -1.5 -0.3 -0.7 -0.7 -0.4 -0.5 -0.2 -0.9 -0.7 -0.0 -1.2 -1.2 0.1 -0.5 -0.3 -1.9 0.9 -0.5 -0.4
Commuting to job workplace: Walk 0.2 0.2 2.1 -0.0 -0.1 -0.3 -0.4 0.1 0.2 -1.4 -0.1 0.0 -0.1 0.5 -0.2 -0.2 -0.5 -0.2 -0.6 0.1 -0.8 0.0 0.0 -0.6 0.1 -0.1 -0.3
Eye problems/disorders: Cataract 1.7 1.9 5.4 1.2 -1.5 -1.2 -1.4 -1.7 -0.7 -0.9 -1.3 -1.4 -1.3 -1.5 -1.4 -1.5 -1.6 -1.3 -2.3 -1.5 -1.2 -1.4 -1.4 -1.4 -1.1 -1.5 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 1.9 1.4 -0.9 -1.2 -1.0 -1.1 -1.2 -0.3 -1.2 -0.8 -1.2 -1.3 -1.0 -1.0 -0.8 -1.3 0.2 -1.2 -0.8 -1.1 -1.2 -0.6 -1.2 -1.2 -1.3
Medication for cholesterol 0.8 1.2 2.3 -1.5 0.8 1.1 1.1 1.0 0.9 0.3 1.3 1.1 1.3 1.2 1.2 1.1 0.9 1.3 0.6 0.9 0.5 1.2 1.4 0.5 1.5 1.4 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.4 0.5 -1.0 -0.7 -0.4 -0.5 -1.2 0.2 -0.7 -0.6 -0.6 -0.6 -0.3 -0.5 -0.7 -0.5 -1.0 -0.9 0.1 -0.3 -0.4 -0.7 0.1 -0.6 -0.8
Back pain experienced in last month 3.8 5.5 10.0 -1.9 2.5 2.5 2.4 2.3 2.7 2.9 2.5 2.4 2.3 1.9 2.5 2.6 2.0 2.1 2.7 2.4 1.8 2.3 2.1 3.2 1.4 2.2 2.2
Mineral and other dietary supplements 7.5 10.1 17.3 -3.2 3.3 3.0 3.2 2.8 4.2 2.7 3.4 3.5 3.2 3.6 3.2 3.4 2.9 3.0 2.2 3.3 2.5 3.6 3.4 3.1 2.8 3.4 2.8
Breast cancer (self-reported) 0.6 0.7 1.9 -0.8 0.5 0.9 0.8 1.1 0.3 0.8 0.8 0.7 0.9 0.6 0.8 0.8 1.0 1.1 0.7 1.0 1.4 0.7 0.8 0.8 0.8 0.8 1.0
Asthma (self-reported) 0.2 0.4 1.2 0.7 -0.5 -0.4 -0.7 -1.1 -0.2 -0.7 -0.5 -0.9 -0.4 -0.5 -0.5 -0.8 0.1 -0.1 -0.6 -0.8 -0.4 -0.7 -0.6 -1.1 -0.7 -0.5 -0.2
Osteoporosis (self-reported) 0.5 0.6 3.4 0.0 -0.8 -0.6 -0.7 -0.8 -0.9 -0.8 -0.4 -0.8 -0.4 -0.6 -0.9 -0.7 -0.6 -0.3 -1.9 -1.2 -0.0 -0.6 -0.2 -1.4 0.1 -0.3 -0.7
Osteoarthritis (self-reported) 3.8 5.0 7.1 2.4 -1.8 -2.2 -2.1 -2.1 -2.5 -1.6 -2.5 -2.1 -2.4 -2.7 -2.3 -2.3 -2.3 -2.4 -1.6 -2.4 -2.1 -2.3 -2.5 -1.8 -2.1 -2.5 -2.1
Medication: Aspirin 1.9 2.5 4.4 1.8 -1.0 -1.9 -1.6 -1.0 -1.3 -1.3 -1.7 -1.6 -1.9 -1.2 -1.9 -1.5 -1.9 -2.1 -1.4 -1.1 -1.6 -1.4 -1.7 -1.0 -2.0 -1.7 -1.7
Medication: Gliclazide 0.2 0.2 1.8 0.0 0.2 0.2 0.1 -0.7 1.2 1.0 0.4 0.3 0.2 0.0 0.3 0.3 -0.1 0.0 -1.3 -0.1 0.0 0.4 0.2 0.4 0.2 0.2 -0.4
Illnesses of father: None of the above (group 1) 11.4 14.1 18.1 -3.9 4.1 3.7 4.0 3.7 3.6 2.9 3.9 3.9 3.9 4.3 4.0 3.9 3.7 3.8 3.1 3.6 3.1 4.0 4.1 3.2 4.0 4.1 3.2
Smoking status: Current 0.1 0.2 1.3 0.4 -0.1 -0.3 -0.4 0.5 -0.2 -0.9 -0.2 -0.3 -0.3 -0.0 -0.6 -0.2 -0.7 -0.4 -0.2 -0.1 -1.2 -0.3 -0.3 0.1 -0.7 -0.3 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.3 -0.7 0.9 0.8 1.1 1.2 0.6 1.5 0.8 1.0 0.8 0.5 0.9 1.0 0.5 0.7 1.1 0.9 1.1 0.9 0.9 1.2 1.0 0.9 0.8
Whole body water mass 7.7 43.9 59.6 -7.5 7.0 7.1 6.7 5.0 5.6 4.6 7.1 6.6 7.4 6.9 7.1 6.7 6.7 7.7 5.3 6.0 6.0 7.1 7.4 5.0 7.1 7.3 6.6
Leg predicted mass (right) 7.8 41.5 55.8 -7.2 6.8 7.0 6.5 4.9 5.4 4.3 7.0 6.5 7.2 6.8 6.9 6.6 6.3 7.5 5.5 5.9 5.7 7.0 7.2 5.1 6.6 7.1 6.4
Arm fat mass (left) 2.5 10.4 14.1 -3.5 3.7 3.2 3.1 2.2 3.1 1.7 3.5 3.8 3.5 3.6 3.6 3.5 2.5 3.5 3.3 3.1 2.0 3.7 3.6 2.9 3.1 3.6 2.7
Number of self-reported non-cancer illnesses 2.4 4.2 7.0 2.1 -1.6 -2.2 -2.1 -2.0 -2.3 -1.2 -2.2 -1.9 -2.2 -2.6 -2.1 -2.0 -2.5 -2.1 -1.5 -2.2 -1.5 -2.0 -2.2 -1.5 -2.0 -2.2 -2.0
Average weekly champagne plus white wine intake 0.3 0.4 2.3 -0.0 -0.9 -0.6 -0.6 -0.7 -0.6 -1.1 -0.6 -0.6 -0.3 0.0 -0.3 -0.7 -0.5 -0.1 -1.3 -0.8 -0.2 -0.3 -0.2 -1.5 0.4 -0.4 -0.1
Miserableness 1.0 1.7 6.0 0.9 -0.6 -1.2 -1.4 -0.7 -1.4 -2.1 -1.1 -1.0 -1.1 -0.7 -1.1 -1.3 -2.5 -1.1 -1.3 -1.2 -2.3 -1.0 -1.1 -1.5 -0.8 -1.2 -1.2
Guilty feelings 1.4 2.1 5.2 1.2 -1.1 -1.3 -1.4 -0.2 -2.2 -1.6 -1.4 -1.4 -1.4 -1.6 -1.5 -1.3 -2.3 -1.4 -0.2 -1.1 -1.9 -1.4 -1.4 -0.9 -1.7 -1.4 -1.2
Wears glasses or contact lenses 0.0 0.0 0.4 -0.0 -0.1 -0.1 0.1 -0.1 -0.6 -0.2 -0.1 -0.0 -0.1 -0.1 -0.1 0.1 -0.5 -0.1 0.1 -0.0 -0.3 0.1 -0.0 0.1 -0.1 -0.0 -0.0
Ever taken oral contraceptive pill 1.1 1.3 2.8 1.1 -0.9 -1.2 -1.1 -1.6 -0.5 -0.9 -1.1 -1.0 -1.1 -1.1 -1.0 -1.0 -0.9 -1.2 -1.7 -1.1 -1.2 -0.9 -1.0 -1.0 -1.0 -1.0 -1.6
Hearing aid user 0.5 0.5 1.9 -0.6 0.4 0.7 0.8 1.1 0.4 0.7 0.6 0.8 0.6 0.8 0.9 0.6 0.2 0.7 1.4 0.6 0.2 0.7 0.6 0.6 0.9 0.6 0.8
Mother’s age at death 5.6 7.0 11.0 -3.0 2.2 2.7 2.8 2.2 1.9 1.9 2.6 2.3 2.8 2.9 2.7 2.6 3.3 2.9 2.2 2.5 3.1 2.6 2.8 2.1 2.9 2.7 3.1
Financial situation satisfaction 3.1 3.8 6.8 -1.7 1.7 2.1 2.0 2.6 2.5 2.4 1.9 2.0 1.9 1.9 2.1 1.9 1.7 1.8 1.8 2.1 1.6 1.8 1.8 2.0 1.7 1.8 1.9
Tinnitus: Yes, now most or all of the time 3.1 3.7 6.5 -1.8 1.8 2.2 1.8 1.6 1.9 1.0 2.1 1.9 2.1 1.8 2.0 1.9 2.2 2.1 2.5 2.1 1.7 1.7 1.9 2.0 1.3 2.0 1.9
Commuting to job workplace: Public transport 0.7 0.8 1.6 0.8 -1.2 -1.2 -0.9 -0.8 -1.3 -0.8 -1.1 -1.0 -1.0 -0.6 -0.9 -0.9 -0.5 -1.1 -0.8 -0.7 -0.2 -0.8 -0.9 -1.0 -0.6 -1.0 -1.1
Eye problems/disorders: Glaucoma 0.4 0.5 2.3 0.8 -0.9 -0.6 -0.7 -1.2 0.0 -0.2 -0.6 -0.9 -0.7 -0.8 -0.8 -0.5 -0.0 -0.9 -0.3 -0.4 -0.4 -0.8 -0.8 0.1 -1.5 -0.7 -0.7
Medication: Blood pressure 1.7 3.2 4.6 2.1 -1.4 -1.8 -1.8 -1.3 -1.2 -1.0 -2.0 -1.7 -2.0 -2.1 -1.9 -2.0 -1.9 -1.9 -1.2 -1.8 -1.6 -2.1 -2.2 -1.4 -2.0 -2.1 -1.5
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.7 0.3 0.2 0.0 0.0 0.6 -0.2 -0.4 -0.1 0.4 -0.2 -0.2 0.3 0.2 -0.9 -0.3 1.3 0.4 -1.0 0.1 -0.3 1.1 -0.5 -0.3 -0.1
Supplements: Fish oil (including cod liver oil) 4.1 5.3 8.2 2.4 -2.5 -2.2 -2.3 -2.6 -2.6 -1.8 -2.5 -2.5 -2.4 -2.9 -2.5 -2.5 -1.6 -2.2 -1.1 -2.5 -1.8 -2.8 -2.6 -2.1 -2.3 -2.5 -1.7
High cholesterol (Self-reported) 1.1 2.0 3.1 1.8 -1.2 -1.5 -1.5 -1.4 -1.6 -1.2 -1.5 -1.2 -1.6 -1.5 -1.2 -1.3 -1.7 -1.6 -1.2 -1.1 -1.1 -1.2 -1.6 -0.7 -1.4 -1.6 -1.6
Medication: Bendroflumethiazide 1.9 2.8 4.7 1.9 -1.1 -1.8 -1.5 -1.6 -1.5 -0.9 -1.8 -1.3 -1.9 -2.2 -1.8 -1.6 -2.0 -2.0 -1.4 -2.0 -1.9 -1.7 -1.8 -1.1 -1.4 -1.8 -1.8
Medication: Paracetamol 3.3 5.2 7.8 2.3 -2.2 -2.6 -2.4 -2.1 -1.7 -2.5 -2.2 -1.9 -2.4 -1.9 -2.6 -2.1 -2.7 -2.7 -1.6 -1.8 -2.8 -2.1 -2.2 -1.6 -2.7 -2.2 -2.4
Medication: Lisinopril 0.2 0.2 2.6 -0.3 0.1 -0.1 0.1 0.5 -1.0 0.1 -0.2 -0.4 0.1 0.0 -0.3 -0.1 0.7 0.3 -0.2 -0.3 1.6 0.0 0.3 -0.7 0.5 0.1 0.2
Medication: Atorvastatin 0.4 0.5 2.2 -0.5 0.7 0.5 0.6 0.6 0.3 1.2 0.5 0.9 0.4 -0.0 0.7 0.8 -0.2 0.3 0.7 0.7 0.6 0.8 0.4 1.5 0.3 0.4 0.5
Illnesses of father: High blood pressure 5.1 6.3 9.7 2.4 -2.7 -2.4 -2.7 -3.1 -2.5 -2.8 -2.4 -2.2 -2.4 -2.8 -2.3 -2.5 -2.8 -2.2 -2.3 -2.5 -2.6 -2.3 -2.5 -2.2 -2.3 -2.6 -2.5
Alcohol drinker status: Never 1.0 1.2 2.7 0.6 -0.8 -1.5 -1.0 -0.3 -1.6 -1.6 -1.2 -1.2 -1.1 -0.6 -1.1 -1.0 -1.3 -1.1 -1.4 -1.1 -0.5 -0.8 -0.6 -1.6 -0.3 -0.9 -1.4
Ever smoked 1.0 1.8 3.4 1.4 -1.7 -1.4 -1.3 -1.8 -1.1 -0.9 -1.3 -1.3 -1.3 -1.5 -1.5 -1.3 -0.9 -1.4 -1.1 -1.5 -1.0 -1.4 -1.3 -1.1 -1.3 -1.3 -1.3
Basal metabolic rate 7.3 40.6 54.8 -7.1 6.8 6.9 6.4 4.8 5.4 4.3 6.9 6.5 7.1 6.7 6.9 6.5 6.3 7.4 5.2 5.8 5.6 6.9 7.1 4.9 6.8 7.0 6.3
Leg fat percentage (left) 0.1 0.2 0.8 -0.1 0.8 0.0 0.1 0.0 0.3 -0.6 0.3 0.7 0.2 0.4 0.4 0.5 -0.6 0.0 0.9 0.5 -0.7 0.5 0.3 0.6 -0.0 0.3 -0.3
Arm fat-free mass (left) 6.9 35.0 47.9 -6.7 6.3 6.4 6.0 4.4 5.1 4.1 6.3 6.0 6.6 6.1 6.3 6.0 6.0 6.9 4.8 5.2 5.4 6.3 6.6 4.3 6.4 6.5 6.0
Number of operations (self-reported) 0.3 0.4 2.0 0.7 -0.7 -0.6 -0.4 0.2 -1.4 0.3 -0.8 -0.6 -0.7 -1.0 -0.6 -0.6 -0.8 -0.6 0.4 -0.6 0.2 -0.7 -0.7 -0.2 -0.5 -0.7 -0.3
Average weekly beer plus cider intake 4.5 6.6 9.1 2.6 -2.4 -2.7 -2.8 -1.9 -2.5 -3.0 -2.6 -2.4 -2.5 -2.5 -2.8 -2.6 -2.9 -2.5 -2.0 -2.5 -2.6 -2.5 -2.4 -2.5 -2.5 -2.5 -2.8
Irritability 0.2 0.4 1.0 0.8 -0.1 -0.6 -0.6 0.0 -0.2 -0.5 -0.5 -0.7 -0.6 -0.2 -0.7 -0.5 -0.9 -0.8 -0.5 -0.2 -1.0 -0.6 -0.6 -0.2 -0.9 -0.5 -0.9
Risk taking 3.2 4.7 8.6 2.5 -2.0 -2.4 -2.3 -2.9 -0.8 -2.1 -2.1 -1.7 -2.3 -2.3 -2.2 -2.0 -2.0 -2.5 -1.8 -1.9 -2.5 -2.0 -2.2 -1.5 -2.5 -2.2 -2.0
Ever had prostate specific antigen (PSA) test 5.4 6.2 8.8 -2.9 2.4 2.5 2.8 2.4 0.6 2.3 2.4 2.6 2.6 2.2 2.6 2.7 1.9 2.6 2.5 2.4 2.9 2.7 2.6 2.3 3.0 2.6 2.6
Fractured/broken bones in last 5 years 0.1 0.1 0.3 -0.1 0.3 0.3 -0.1 0.5 0.6 -0.4 0.1 -0.2 0.2 0.3 -0.0 -0.1 0.6 0.3 -0.5 0.1 0.1 -0.1 -0.0 -0.2 -0.1 -0.0 0.6
Age started oral contraceptive pill 1.3 1.6 3.2 1.3 -1.4 -1.4 -1.3 -1.3 -1.0 -0.7 -1.5 -1.3 -1.3 -1.0 -1.2 -1.5 -0.9 -1.2 -1.3 -1.6 -1.0 -1.2 -1.2 -1.8 -0.9 -1.3 -1.2
Diastolic blood pressure, automated reading 0.2 0.5 1.6 0.7 -0.5 -0.7 -0.8 -0.7 0.0 -0.7 -0.6 -0.5 -0.7 -0.5 -0.8 -0.7 -0.9 -0.8 -0.9 -0.5 -1.3 -0.7 -0.8 -0.5 -0.8 -0.7 -0.8
Ever depressed for a whole week 0.1 0.1 0.3 0.6 -0.1 -0.3 -0.3 -0.2 -0.1 -0.1 -0.5 -0.2 -0.4 -0.4 -0.1 -0.3 -0.2 -0.4 0.1 -0.2 -0.1 -0.3 -0.5 -0.0 -0.4 -0.5 -0.1
Unable to work because of sickness or disability 0.1 0.1 0.5 -0.1 0.3 -0.3 -0.2 -0.4 -0.5 -0.5 -0.0 0.1 -0.2 -0.4 -0.4 0.1 -0.7 -0.4 -0.2 -0.1 -0.1 0.2 0.1 0.4 -0.4 -0.0 -0.5
Commuting to job workplace: Cycle 0.2 0.2 0.8 0.2 -0.4 -0.2 -0.6 -0.3 -0.2 -0.7 -0.4 -0.4 -0.4 -0.3 -0.6 -0.5 -0.6 -0.4 -0.4 -0.4 -0.9 -0.6 -0.7 -0.1 -0.8 -0.6 -0.2
Myopia 0.1 0.2 0.6 -0.7 0.4 0.1 0.3 -0.2 0.2 0.3 0.4 0.6 0.4 0.1 0.1 0.5 0.3 0.4 -0.3 0.2 0.8 0.6 0.6 0.2 0.5 0.5 0.4
Vascular/heart problems diagnosed by doctor 1.4 3.9 7.5 -2.2 1.3 2.0 2.1 1.4 1.6 1.9 2.0 1.7 2.1 2.0 2.2 1.9 2.7 2.2 1.4 1.6 2.5 1.9 2.2 1.1 2.5 2.1 1.8
Cholesterol lowering medication 0.2 0.4 0.7 0.7 -0.4 -0.6 -0.6 -0.5 -0.8 -0.4 -0.8 -0.6 -0.7 -0.6 -0.5 -0.7 -0.7 -0.5 -0.6 -0.6 -0.3 -0.6 -0.8 -0.7 -0.4 -0.8 -0.2
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.8 -0.9 1.1 0.9 1.1 0.2 1.3 1.7 0.9 1.0 1.0 1.1 0.9 1.0 1.1 1.0 0.5 0.7 1.2 1.0 1.1 0.7 1.1 1.0 1.1
Pain experienced in last month 0.1 0.2 1.4 0.1 -0.8 -0.3 -0.3 -0.5 0.3 0.0 -0.6 -0.4 -0.3 0.2 -0.3 -0.7 0.8 -0.0 -0.2 -0.5 0.3 -0.5 -0.3 -1.2 0.1 -0.4 0.4
Supplements: Calcium 2.0 2.2 3.6 1.4 -1.3 -1.6 -1.4 -1.9 -1.6 -1.0 -1.6 -1.5 -1.6 -1.6 -1.7 -1.5 -1.0 -1.6 -0.9 -1.7 -1.1 -1.7 -1.6 -1.3 -1.5 -1.5 -1.6
Basal cell carcinoma (self-reported) 2.2 2.6 5.2 1.3 -1.7 -1.4 -1.8 -1.9 -1.2 -2.3 -1.4 -1.6 -1.4 -1.5 -1.6 -1.7 -1.8 -1.2 -1.5 -1.6 -2.0 -1.6 -1.4 -1.9 -1.5 -1.5 -1.4
Heart attack/myocardial infarction (self-reported) 0.4 0.5 2.0 0.7 0.2 -0.8 -0.8 -0.8 -0.4 -0.9 -0.5 -0.8 -0.6 -0.6 -0.9 -0.5 -0.7 -0.7 -0.3 -0.6 -0.9 -0.6 -0.6 -0.3 -1.4 -0.5 -0.8
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.6 -1.2 0.5 1.1 0.8 0.6 0.6 0.8 0.9 0.9 1.0 0.9 1.0 0.8 0.9 1.1 1.1 0.9 1.1 0.8 0.8 1.0 0.7 0.8 1.3
Heart disease (siblings) 0.3 0.3 1.0 0.4 -0.3 -0.5 -0.7 -0.4 -0.3 -0.8 -0.5 -0.6 -0.5 -0.2 -0.8 -0.5 -0.9 -0.4 0.5 -0.5 -0.8 -0.6 -0.5 -0.5 -1.0 -0.5 -0.1
Alcohol drinker status: Previous 0.4 0.4 2.6 0.4 0.2 -0.3 -0.7 -1.1 0.1 -1.6 -0.2 -0.5 -0.3 -0.1 -0.6 -0.4 -0.6 -0.3 -0.8 -0.5 -1.2 -0.1 -0.3 -0.4 -0.9 -0.3 -0.6
Pack years of smoking 0.2 0.3 0.6 -0.5 0.6 0.5 0.1 0.5 0.2 -0.8 0.6 0.4 0.6 0.6 0.5 0.6 -0.4 0.5 0.6 0.7 -0.4 0.7 0.5 0.7 -0.1 0.5 -0.0
Impedance of whole body 3.5 17.6 23.2 4.5 -4.8 -4.4 -4.4 -3.1 -3.5 -3.0 -4.5 -4.2 -4.5 -4.3 -4.6 -4.4 -4.3 -4.6 -3.6 -3.9 -3.7 -4.6 -4.6 -3.6 -4.3 -4.6 -3.9
Leg fat mass (left) 2.0 7.8 11.3 -3.0 3.4 2.8 2.7 2.1 2.5 1.4 3.0 3.3 3.0 3.1 3.1 3.1 2.0 2.9 2.9 2.8 1.6 3.3 3.1 2.6 2.7 3.1 2.3
Arm predicted mass (left) 7.1 36.2 48.4 -6.8 6.4 6.4 6.1 4.6 5.1 4.2 6.4 6.1 6.7 6.2 6.4 6.1 6.0 7.0 5.0 5.4 5.4 6.5 6.7 4.6 6.4 6.6 6.0