Hub : Genes

SLC26A9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1340 0.0310 6.0e-12 0.164 0.108 0.157 0.156 0.162 1.6e-19 4.4e-13 1.0e-18 1.7e-18 3.1e-19
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0658 0.0272 7.7e-06 0.067 0.042 0.057 NA 0.059 5.5e-08 1.5e-05 5.0e-07 NA 3.3e-07
3 TCGA Kidney Renal Papillary Cell Carcinoma 0.1350 0.0580 3.4e-04 0.002 0.069 0.067 NA 0.040 2.5e-01 9.1e-05 1.1e-04 NA 2.4e-03
4 TCGA Brain Lower Grade Glioma 0.0310 0.0179 7.4e-03 0.023 0.009 0.006 NA 0.013 9.9e-04 3.3e-02 6.0e-02 NA 1.1e-02
5 TCGA Pancreatic Adenocarcinoma 0.1540 0.0770 2.4e-03 0.058 0.044 0.043 NA 0.046 1.9e-03 6.0e-03 6.7e-03 NA 5.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.0 1.5 5.5 2.3 -0.0 1.4 0.1 0.3
Bipolar Disorder or Schizophrenia 0.5 1.3 6.2 2.5 0.0 -0.1 -0.4 -0.5
Depressed Affect (Nagel 2018) 1.4 2.9 8.5 2.3 -0.4 2.9 -0.6 0.5
Depression (Nagel 2018) 1.3 2.0 9.2 -0.1 0.1 3.0 -0.3 0.9
Intelligence (Savage-Jansen 2018) 0.6 2.0 5.3 -2.3 -1.0 -1.0 0.3 1.6
Neuroticism (Nagel 2018) 1.0 2.3 5.2 2.3 -0.7 2.0 -1.2 0.6
Schizophrenia (2018) 0.4 0.9 1.8 1.3 0.1 -1.2 -0.6 -0.9
Schizophrenia vs Biploar Disorder 0.8 1.1 2.3 -1.4 0.4 0.3 -0.9 1.5
Worry (Nagel 2018) 0.9 2.0 7.3 2.7 -0.0 1.0 -1.1 -0.8
Alzheimer’s Disease (in mother) 0.8 0.9 1.4 1.2 1.1 -0.9 -0.4 -0.9
Alzheimer’s Disease (in father) 1.1 1.2 4.1 2.0 -0.3 1.3 0.6 0.1
Alzheimer’s Disease (including proxy) 0.6 0.9 2.9 1.7 1.0 -0.3 -0.6 -0.3
Crohns Disease (2017) 0.7 1.5 3.8 2.0 -0.2 0.1 0.5 -1.8
Irritable Bowel Disease (IBD) 1.0 2.3 8.1 2.9 -0.7 -0.3 0.0 -1.7
Ulcerative Colitis (UC) 1.4 2.7 9.1 3.0 -0.8 -1.1 -0.7 -1.4
Major Depression (MDD) 0.5 0.6 1.3 1.2 -0.4 -1.1 0.6 0.0
Reaction Time 3.1 5.9 25.7 5.1 -1.0 -0.2 -1.2 -1.3
Verbal and Numeric Reasoning (VNR) 0.5 1.1 4.7 -2.2 0.3 -0.2 0.5 0.7
Breast Cancer 0.5 1.1 2.4 1.1 1.6 -0.7 -1.0 -0.7
Ovarian Cancer 0.8 1.0 4.1 -0.3 0.5 0.4 -2.0 0.7
Prostate Cancer 4.9 6.9 20.8 -4.6 1.0 2.2 0.5 2.8
Age at First Birth 0.1 0.1 0.4 0.2 0.7 -0.2 0.1 0.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 2.9 4.0 11.5 -3.4 0.0 1.2 1.9 1.8
Coronary Artery Disease (CAD) 0.9 1.1 4.9 -2.2 -0.5 0.2 0.5 0.0
Crohns Disease (2012) 1.1 1.7 4.2 1.9 -0.4 -0.3 0.7 -2.0
Mean Putamen Volume 0.4 0.5 1.7 0.5 0.2 -1.3 -0.3 0.5
Fasting Glucose 0.8 1.0 3.9 -0.9 0.2 0.1 0.7 -2.0
HbA1C 1.6 1.8 6.3 -2.5 -0.8 -0.7 0.2 1.2
HDL Cholesterol 1.7 2.9 6.8 2.6 1.1 -1.2 -2.3 0.2
LDL Cholesterol 0.0 0.1 0.3 -0.3 0.5 -0.1 0.0 0.1
Lupus 0.7 1.1 2.5 1.4 0.3 -0.7 -1.6 -0.7
Neuroticism (2016) 0.8 1.1 4.2 1.0 0.2 2.0 -0.5 0.4
Primary Biliary Cirrhosis 0.8 1.2 3.5 -1.9 -1.1 0.9 0.5 0.2
Rheumatoid Arthritis 1.8 2.5 5.2 0.9 -2.1 0.2 -1.4 2.3
Schizophrenia (2014) 0.3 0.7 2.8 1.7 -0.1 -0.3 -0.2 -0.7
Triglycerides 0.4 0.7 1.2 -0.6 -1.1 -0.8 0.5 -1.1
Type 2 Diabetes (T2D) (2012) 2.6 3.1 7.7 -2.5 -0.4 -0.3 -1.0 2.8
Ulcerative Colitis 1.1 1.6 3.7 1.9 -1.1 -1.3 -0.7 -1.1
Blood Eosinophil Count 0.6 4.6 8.4 -2.1 0.9 2.9 1.4 2.7
Blood Platelet Count 0.2 2.0 4.0 -1.8 0.7 1.3 -0.9 2.0
Blood Red Count 0.0 0.5 0.9 -0.4 -0.7 -1.0 -0.8 0.3
Blood White Count 0.3 2.3 9.1 0.7 0.4 3.0 0.8 1.0
Heel T-Score 0.3 2.1 7.6 -1.3 2.8 -1.0 -0.4 -0.6
BMI 0.9 5.4 25.5 -5.0 0.3 -0.5 0.7 0.9
Height 0.8 15.5 68.7 -8.3 1.2 -0.2 1.1 2.5
Waist Hip Ratio (WHR) 0.1 0.6 2.2 0.0 0.6 1.5 -0.3 0.6
Systolic Blood Pressure 0.3 1.6 3.5 1.8 -1.9 -0.1 -0.3 -1.1
Smoking Status 0.3 0.7 2.9 1.7 -0.7 0.5 0.1 0.0
Allergy or Eczema 0.6 1.6 5.3 -1.4 0.7 0.4 0.5 2.3
Cardiovascular Disease 1.1 3.6 8.1 2.8 -2.5 -1.0 -1.5 -0.7
Hypothyroidism (self reported) 0.1 0.3 0.6 0.7 0.1 0.6 0.2 -0.8
Respiratory disease 0.5 1.2 2.1 -1.0 -1.5 -1.1 -0.3 1.3
Type 2 Diabetes (T2D) (2018) 2.0 3.8 6.7 -2.5 -2.6 -1.9 1.6 0.0
Lung FEV1/FVC ratio 2.7 13.6 33.2 -5.4 -0.3 2.1 1.2 5.8
Lung FVC 0.5 2.6 6.7 2.6 -1.9 -1.1 -1.1 -0.8
Neuroticism 1.4 3.4 9.1 3.0 -1.3 2.5 -0.2 -0.4
Chronotype (morning person) 0.2 0.5 1.5 -0.8 -0.5 1.2 0.4 -0.3
Hair Pigment 0.3 7.1 25.7 5.1 1.1 0.7 -2.8 0.6
Tanning 0.1 1.2 2.8 0.5 1.2 1.7 0.6 1.0
Hand grip strength (left) 4.0 10.4 46.9 -6.8 0.4 0.2 0.5 2.2
Number of treatments/medications taken 2.1 3.7 10.0 3.2 -1.7 -1.3 -1.8 -0.8
Average weekly spirits intake 0.3 0.4 0.9 -1.0 -0.9 -0.2 0.2 -0.0
Sensitivity / hurt feelings 0.5 0.9 1.6 1.1 -1.3 0.6 -1.2 0.4
Frequency of depressed mood in last 2 weeks 0.8 1.1 3.4 1.0 0.2 1.8 -1.1 -0.3
Hearing difficulty/problems: Yes 1.2 1.8 6.5 -2.5 -1.3 -0.8 -0.1 0.4
Relative age of first facial hair 0.5 1.1 2.8 1.1 -0.1 -0.9 -1.7 0.8
Other serious medical condition/disability diagnosed by doctor 1.7 2.2 6.0 2.5 -0.9 -1.5 -0.4 -1.4
Ever used hormone-replacement therapy (HRT) 0.4 0.6 2.4 0.2 -0.1 1.6 0.3 0.5
Ever had hysterectomy (womb removed) 0.0 0.0 0.0 0.0 0.1 -0.2 0.1 -0.1
Systolic blood pressure, automated reading 0.4 1.1 2.8 1.7 -1.2 -0.3 -0.3 -1.0
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 2.7 0.0 -1.2 -1.2 1.6 -1.2
Angina 1.0 1.4 2.8 0.7 -1.5 -0.7 0.8 -1.7
Medication for hormone replacement therapy 0.6 0.7 1.4 0.6 0.2 -1.2 -1.0 -0.9
Vitamin and mineral supplements 1.7 2.2 10.2 -3.2 -0.7 -0.2 0.5 -0.5
Supplements: Zinc 0.9 0.9 3.6 -0.1 1.9 0.0 1.0 -0.0
Medication: Co-codamol 1.3 1.6 2.6 1.4 1.0 -1.3 -1.6 -0.7
Medication: Metformin 1.9 2.7 5.5 -1.9 -2.1 -2.3 0.3 -0.1
Diabetes (father) 0.0 0.1 0.1 0.3 -0.4 0.1 -0.1 -0.1
Diabetes (mother) 0.9 1.1 2.1 -0.4 1.4 1.3 0.9 1.0
Severe depression (siblings) 3.1 3.4 8.5 2.9 0.2 -0.3 -2.9 0.0
Pack years adult smoking proportion 0.9 1.3 2.6 -0.4 -1.6 -0.7 -1.1 -1.5
Impedance of leg (right) 1.5 7.0 25.6 5.1 -1.9 0.2 0.1 -2.4
Leg fat-free mass (left) 2.3 12.4 51.8 -7.2 1.4 -0.6 -0.4 2.8
Trunk fat percentage 0.1 0.4 1.2 -1.1 -0.9 0.0 0.1 -0.4
Hand grip strength (right) 5.0 13.5 59.1 -7.7 -0.1 0.6 -0.3 2.8
Townsend deprivation index at recruitment 1.3 1.8 3.3 1.7 -1.8 -0.9 -1.4 -0.3
Current tobacco smoking 0.5 0.8 3.1 0.6 0.6 1.8 -0.2 0.1
Average weekly fortified wine intake 2.3 2.7 6.0 2.2 1.4 2.4 -1.1 0.2
Maternal smoking around birth 0.6 0.8 2.0 1.4 0.1 0.5 -0.2 -1.3
Fed-up feelings 0.5 0.9 3.5 1.0 -0.2 1.9 0.2 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 5.6 -0.2 -0.0 2.4 -1.8 1.2
Relative age voice broke 0.1 0.2 0.4 0.5 0.4 0.3 -0.6 -0.1
Taking other prescription medications 1.1 1.7 3.7 1.6 -1.9 -0.8 -1.3 -0.2
Age when periods started (menarche) 2.3 5.6 16.3 4.0 -1.7 -1.6 0.2 -2.5
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 1.7 -0.6 -0.0 1.3 -1.2 1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.8 -0.6 -0.2 -0.7 -0.6 -1.4
Tinnitus: Yes, but not now, but have in the past 0.3 0.4 0.6 -0.6 0.7 0.5 -0.5 0.8
Qualifications: CSEs or equivalent 1.2 1.6 4.9 0.6 -1.3 0.2 -1.1 2.2
Serious illness, injury or assault to yourself 0.5 0.6 1.2 1.0 -0.9 -0.1 0.0 -1.1
High blood pressure 0.9 2.5 5.0 2.1 -2.2 0.2 -1.7 0.2
Hayfever, allergic rhinitis or eczema 0.6 1.3 5.1 -1.0 0.4 -0.5 0.2 2.3
Multivitamins +/- minerals 3.2 4.0 14.7 3.8 0.4 -0.2 -2.3 0.3
Stomach or abdominal pain in last month 1.0 1.3 4.1 1.4 -2.0 0.3 -0.1 -0.4
Supplements: Glucosamine 3.1 4.0 8.5 2.9 2.5 2.0 -0.8 -0.9
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.3 1.5 -0.7 -1.0 -1.5 0.4
Medication: Atenolol 1.2 1.6 3.5 1.4 -0.5 1.9 -1.4 0.4
Medication: Levothyroxine sodium 1.1 1.8 4.0 2.0 -1.0 -1.2 -0.4 -1.6
Sitting height 3.1 21.7 83.5 -9.1 2.5 0.1 2.0 3.8
Chronic bronchitis/emphysema (father) 0.9 1.1 2.1 -0.8 -1.0 -0.3 -1.3 1.4
High blood pressure (mother) 1.1 1.5 3.2 1.7 1.1 1.8 -0.4 0.5
Body mass index (BMI) 0.5 1.9 7.3 -2.7 -0.2 -0.5 -1.1 0.9
Impedance of leg (left) 1.5 7.4 24.2 4.9 -2.1 0.0 0.4 -2.8
Leg predicted mass (left) 2.4 12.6 52.1 -7.2 1.4 -0.7 -0.4 2.9
Trunk fat mass 0.5 2.2 10.4 -3.2 -0.4 -0.3 -0.2 0.6
Waist circumference 0.7 2.5 8.9 -3.0 -0.1 -0.6 -1.5 1.0
Number of incorrect matches in round 2.5 4.1 16.8 4.1 -0.2 0.6 -0.7 -1.6
Past tobacco smoking 0.5 1.0 1.9 -1.0 0.1 1.4 0.8 -1.1
Alcohol usually taken with meals 0.5 0.9 3.1 1.8 -0.2 -0.6 -0.9 -0.0
Nervous feelings 0.9 1.8 7.8 2.8 -0.2 0.8 -0.2 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 2.0 1.4 0.1 1.4 0.2 -0.9
Hearing difficulty/problems with background noise 3.2 5.1 17.8 -4.2 0.6 0.1 2.6 -0.9
Hair/balding pattern: Pattern 2 1.2 1.6 3.8 -1.6 0.5 -1.9 0.6 -0.8
Had menopause 0.9 1.1 4.7 0.5 0.3 2.2 0.0 0.7
Had other major operations 0.3 0.3 1.0 0.0 -1.0 0.5 -0.4 -0.6
Forced vital capacity (FVC) 0.4 1.7 4.3 -2.1 -1.5 -0.3 -0.8 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 3.1 -1.8 -0.5 -0.4 0.0 0.2
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 2.9 0.6 -1.7 -0.3 -1.3 0.0
Qualifications: None of the above 0.5 1.1 2.7 1.6 -0.7 -0.7 0.0 -1.3
Financial difficulties in last 2 years 0.1 0.2 0.4 -0.1 0.5 -0.4 -0.2 -0.6
Mouth/teeth dental problems 1.9 2.9 4.5 -2.1 2.0 1.5 2.0 0.4
Heart attack 1.3 1.6 5.1 0.8 -2.3 -0.7 -1.0 -1.0
Allergy 0.4 1.0 3.0 1.2 0.0 0.5 -0.4 -1.7
Pain all over the body in last month 1.5 1.6 5.6 -0.6 2.4 0.9 1.1 -0.6
Diabetes (self-reported) 1.8 2.8 7.2 -1.6 -2.7 -1.8 0.9 0.6
Hayfever/allergic rhinitis (self-reported) 1.3 1.8 2.9 -0.9 -1.5 -1.6 -0.1 1.7
Medication: Ramipril 1.5 2.0 4.4 1.0 -2.1 -0.8 -2.0 0.1
Medication: Simvastatin 1.4 2.0 4.1 1.2 -1.0 -2.0 -0.4 -1.8
Fluid intelligence score 0.5 1.1 3.9 -2.0 0.5 -0.3 -0.1 1.1
Illnesses of siblings 0.5 0.7 1.5 -0.3 0.5 -1.2 1.0 -0.8
Neuroticism score 1.5 3.1 9.9 3.1 -1.1 1.5 -1.3 -0.8
Weight 1.6 7.8 32.5 -5.7 0.7 -0.7 -0.9 2.2
Impedance of arm (right) 1.3 6.3 24.5 5.0 -0.4 1.1 1.1 -2.0
Arm fat percentage (right) 0.1 0.3 1.1 -1.1 -0.5 -0.0 -0.5 0.2
Trunk fat-free mass 2.5 14.2 54.9 -7.4 1.9 -1.2 -0.6 3.3
Hip circumference 0.8 3.6 13.0 -3.6 0.0 -1.0 -1.1 1.7
Time employed in main current job 1.6 1.9 5.7 0.4 2.4 -0.3 -1.1 1.4
Alcohol intake versus 10 years previously 0.1 0.2 0.5 -0.2 -0.4 -0.7 -0.3 0.5
Father’s age at death 0.8 1.1 3.8 -0.1 1.9 1.0 -0.5 0.6
Worrier / anxious feelings 1.2 2.3 6.6 2.6 -0.4 1.1 -1.4 -1.3
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 2.6 -0.7 0.8 1.6 -0.4 -0.1
Falls in the last year 1.4 1.9 5.8 -2.4 1.3 0.2 -0.9 1.0
Hair/balding pattern: Pattern 3 1.4 2.0 6.7 2.6 0.5 0.4 -1.3 -1.2
Number of live births 1.6 2.3 3.3 1.8 -1.7 -0.5 -1.6 -1.6
Forced expiratory volume in 1-second (FEV1) 1.4 4.7 12.1 -3.5 -1.4 -0.0 -1.1 2.9
Pulse rate 1.5 2.5 4.5 -2.1 -0.8 -0.8 -1.9 1.8
Happiness 0.6 0.8 2.9 0.9 0.2 1.7 -0.3 0.1
Noisy workplace 0.2 0.2 0.4 0.6 -0.3 -0.1 -0.6 -0.3
Qualifications: A levels/AS levels or equivalent 0.5 1.2 2.5 -1.6 1.0 -0.3 0.7 1.4
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.8 4.9 1.2 -0.8 -2.2 -0.4 -1.2
Mouth/teeth dental problems: Dentures 0.4 0.6 1.4 0.9 -0.3 0.8 0.1 -1.2
Asthma 0.4 0.8 1.6 0.4 -1.0 -1.2 -0.9 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.2 0.6 -0.8 -0.1 1.1 0.4
Medication: Cholesterol lowering 3.5 5.5 10.8 1.1 -3.3 -2.0 1.2 -3.1
Depression (self-reported) 1.3 1.5 4.0 2.0 0.6 0.4 0.3 -1.8
Medication: Lansoprazole 1.1 1.2 3.3 0.1 -1.2 -0.7 -0.9 -1.8
Prospective memory result 1.0 1.3 2.5 1.4 0.5 0.6 1.1 -1.6
Lung cancer (father) 1.3 1.5 4.5 -0.2 1.7 2.1 0.4 0.3
Illnesses of mother 1.9 2.4 6.1 -1.4 -1.6 -2.5 -0.8 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.5 5.7 -2.4 -1.6 -1.4 -0.7 1.3
Pulse wave Arterial Stiffness index 1.5 1.7 3.2 1.5 -1.8 -1.2 -1.3 0.1
Impedance of arm (left) 1.1 5.1 18.0 4.2 -0.5 1.3 1.5 -1.8
Arm fat mass (right) 0.7 2.7 11.7 -3.4 -0.0 -0.2 -0.6 1.2
Trunk predicted mass 2.5 14.4 56.0 -7.5 1.8 -1.2 -0.6 3.3
Standing height 1.4 13.4 52.4 -7.2 1.9 -0.5 0.5 3.2
Length of working week for main job 1.0 1.1 2.5 -1.0 0.1 -1.4 -0.1 1.6
Exposure to tobacco smoke at home 4.4 5.0 16.2 0.3 -1.4 -2.6 -4.0 -0.3
Breastfed as a baby 1.4 1.8 7.3 2.7 0.4 -1.1 -0.3 -0.2
Tense / ‘highly strung’ 2.3 3.8 16.2 4.0 -0.3 0.7 -0.8 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 2.2 3.4 12.4 3.5 -1.5 0.1 -1.1 -1.1
Hair/balding pattern: Pattern 4 0.4 0.9 2.8 -1.2 -1.7 -0.3 0.3 0.3
Birth weight of first child 1.1 2.0 7.0 -2.6 0.3 -1.5 0.1 0.9
Peak expiratory flow (PEF) 14.5 33.6 97.6 -7.8 -1.5 2.3 -1.6 9.9
Pulse wave reflection index 3.4 4.2 11.4 3.4 -1.6 -2.0 -1.0 -1.3
Ever highly irritable/argumentative for 2 days 0.5 0.6 2.3 0.0 -0.7 0.4 -0.0 -1.5
Loud music exposure frequency 1.1 1.2 2.1 -1.1 1.4 -0.6 1.5 -0.5
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 4.0 -2.0 0.8 -0.1 0.3 0.9
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 5.1 0.6 -1.0 -2.2 -2.1 0.2
Blood clot in the leg (DVT) 0.8 1.0 2.0 -0.7 1.4 0.7 0.2 1.4
Medication: Paracetamol 0.7 1.2 2.2 1.4 -1.3 -0.4 -1.5 -0.3
Headache pain in last month 0.7 1.2 3.5 1.9 -0.3 -1.0 -0.7 -0.8
Medication for cholesterol, blood pressure or diabetes 2.3 3.8 12.2 -0.8 3.5 1.3 -0.7 1.9
Glaucoma (self-reported) 0.4 0.4 1.5 1.2 -0.1 0.2 -0.7 0.2
Gout (self-reported) 1.6 2.2 4.7 -1.6 -1.2 -2.2 0.8 -1.3
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.4 1.1 -0.7 -0.2 -0.1 -1.2
Medication: Amlodipine 1.0 1.5 3.9 0.8 -2.0 -1.5 -0.5 -0.7
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.1 -0.5 0.8 1.1 0.2 1.0
Birth weight 2.7 5.8 16.4 -4.0 1.6 0.6 3.0 0.7
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.1 0.9 0.3 0.7 -0.9 1.1
High blood pressure (siblings) 1.1 1.6 4.2 1.2 0.3 2.0 -1.2 1.0
Forced vital capacity (FVC), Best measure 0.4 1.5 3.9 -1.2 -1.2 -2.0 -0.8 0.1
Body fat percentage 0.1 0.5 1.0 -1.0 -1.0 -0.1 -0.5 -0.3
Leg fat percentage (right) 0.2 0.8 2.1 -0.1 -1.3 -0.0 -1.4 -0.2
Arm fat-free mass (right) 2.6 13.6 57.6 -7.6 1.3 -1.0 -0.5 2.7
Exposure to tobacco smoke outside home 1.6 2.1 6.3 0.6 -2.5 -1.5 -0.2 -1.2
Comparative body size at age 10 3.7 10.3 36.7 -6.1 1.5 1.0 1.3 3.1
Number of full brothers 1.2 1.5 4.9 -0.3 -0.7 1.4 -0.3 2.2
Worry too long after embarrassment 0.9 1.4 3.0 0.2 -1.7 -0.6 -1.7 1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 2.9 3.7 16.4 4.0 -0.6 -0.0 -1.1 -0.9
Wheeze or whistling in the chest in last year 0.6 1.1 3.1 -0.6 -1.8 0.2 -1.0 0.9
Number of children fathered 0.3 0.4 1.2 1.1 -0.4 0.1 -0.3 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.8 0.4 -0.7 1.0 0.2 -1.4
Age at first live birth 0.2 0.4 1.2 -1.1 0.5 -0.8 0.2 0.3
Pulse wave peak to peak time 1.6 1.9 3.9 -2.0 1.7 1.0 1.4 0.0
Health satisfaction 0.6 0.8 2.5 0.2 -1.6 0.8 -0.5 0.6
Shortness of breath walking on level ground 0.7 0.9 2.8 0.2 -0.9 -0.8 0.3 -1.7
Qualifications: College or University degree 0.6 1.7 3.3 -1.8 1.6 0.3 1.6 -0.4
Eye problems/disorders: None of the above 1.8 2.0 3.9 -1.9 -1.0 -0.8 -2.0 1.0
Mouth/teeth dental problems: Loose teeth 0.5 0.7 2.1 0.4 0.5 1.5 -0.4 0.8
Emphysema/chronic bronchitis 0.7 0.8 2.4 -0.4 -1.6 -0.7 1.1 -0.2
Medication for pain relief, constipation, heartburn 1.7 2.8 6.7 -2.6 2.1 1.2 0.8 1.0
Neck or shoulder pain in last month 1.0 1.5 3.5 -1.4 -0.7 0.9 1.9 -0.6
Medication: Blood pressure 1.7 3.0 11.3 1.0 -3.4 -1.5 -0.2 -0.5
Angina (self-reported) 0.8 1.1 2.4 0.8 -1.3 -0.6 0.6 -1.5
Migraine (self-reported) 0.7 0.9 1.9 -0.6 -1.4 -0.4 -0.9 1.1
Medication: Ibuprofen 0.4 0.5 0.9 0.9 -0.3 0.6 0.9 0.8
Medication: Allopurinol 2.1 2.7 8.8 -1.0 -1.8 -3.0 -0.2 -0.9
Medication: Omeprazole 1.1 1.4 3.7 -0.1 -0.2 -1.9 -1.7 0.5
Medication: Seretide 50 evohaler 0.2 0.3 0.8 0.1 -0.2 -0.1 0.7 -0.9
Mean time to correctly identify matches 4.3 8.1 36.1 6.0 -1.2 0.0 -0.9 -1.5
Heart disease (mother) 0.8 0.9 2.4 0.5 -0.0 1.6 1.2 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.7 0.4 -0.3 -0.8 0.8 -1.3
Whole body fat mass 0.6 2.5 11.7 -3.4 -0.4 -0.3 -0.4 0.7
Leg fat mass (right) 0.5 2.0 8.9 -3.0 -0.5 -0.3 -0.8 0.5
Arm predicted mass (right) 2.7 13.6 57.3 -7.6 1.2 -1.2 -0.7 2.8
Pulse rate, automated reading 1.8 5.8 24.0 -4.9 -1.3 -0.7 0.6 1.6
Alcohol intake frequency. 0.1 0.3 0.6 -0.6 -0.7 0.1 -0.2 0.8
Comparative height size at age 10 2.6 14.0 49.7 -7.0 3.4 -0.3 1.4 2.6
Number of full sisters 0.8 0.9 1.2 -0.4 -1.0 1.1 1.0 1.1
Suffer from ‘nerves’ 0.5 0.8 2.7 0.7 -0.3 1.6 -0.2 0.8
Overall health rating 0.9 1.9 5.9 0.9 -2.4 -1.1 -0.7 -1.0
Chest pain or discomfort 0.4 0.6 2.5 -0.2 -1.6 -0.3 -0.4 0.4
Had major operations 0.3 0.4 1.1 0.5 -1.0 -0.6 -0.0 0.5
Age at last live birth 0.6 0.9 1.8 -1.1 0.1 -1.4 -1.1 0.4
Family relationship satisfaction 1.4 1.7 3.4 0.9 0.2 1.8 0.9 1.9
Leg pain on walking 0.4 0.5 1.3 0.4 -0.1 1.1 1.0 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.5 -0.3 -1.2 0.6 -0.6 0.3
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.7 -0.8 -0.1 -0.9 0.7 -1.6
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 3.1 -1.0 1.7 1.2 1.8 0.6
Medication: Aspirin 0.9 1.2 2.7 1.6 -1.5 -0.4 -1.0 0.0
Supplements: Vitamin C 0.9 1.1 2.6 0.7 -0.2 1.6 1.3 0.9
Knee pain experienced in last month 0.6 0.9 2.6 1.2 -0.7 1.6 0.4 -0.1
Hypertension (Self-reported) 0.9 2.5 7.5 1.9 -2.7 -0.0 -1.2 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 4.7 1.2 -0.0 -1.0 -2.2 -0.1
Illnesses of father: Heart disease 1.2 1.7 6.6 2.6 -1.3 0.4 0.2 0.1
Illnesses of siblings: Diabetes 0.5 0.6 2.4 -1.5 -0.1 0.5 0.8 0.0
Smoking status: Previous 0.6 0.9 1.7 1.1 0.3 -1.3 -0.1 1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.3 -1.5 0.6 -0.5 -0.8 0.9
Whole body fat-free mass 2.5 14.5 58.8 -7.7 1.7 -1.0 -0.4 3.1
Leg fat-free mass (right) 2.5 13.1 55.1 -7.4 1.5 -0.8 -0.2 2.8
Arm fat percentage (left) 0.1 0.5 2.0 -1.4 -0.6 -0.0 -0.4 0.3
Average weekly red wine intake 0.5 0.8 1.9 1.4 -1.2 -0.0 -0.7 -0.2
Handedness (chirality/laterality): Left-handed 2.4 2.9 5.7 1.5 2.1 2.4 1.3 0.4
Mood swings 2.6 4.7 17.9 4.2 -0.3 2.1 -0.9 0.4
Loneliness, isolation 0.9 1.2 2.4 1.3 -0.2 1.4 -1.6 0.2
Long-standing illness, disability or infirmity 3.5 5.4 11.8 1.2 -3.4 -2.9 -0.2 -2.3
Ever had bowel cancer screening 1.2 1.4 4.1 0.7 -2.0 -0.5 -0.1 -1.4
Diabetes diagnosed by doctor 2.4 4.0 9.2 -1.9 -3.0 -1.9 1.8 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 2.2 0.6 1.5 0.6 -0.6 0.4
Friendships satisfaction 1.4 1.7 4.3 0.6 -0.1 1.8 0.7 2.1
Qualifications: nursing, teaching 0.8 1.3 5.1 0.2 2.2 0.6 1.1 -0.0
Commuting to job workplace: Walk 0.6 0.7 1.6 -0.1 -0.1 1.0 -1.3 0.8
Eye problems/disorders: Cataract 1.4 1.6 3.2 1.5 0.6 1.5 1.8 0.2
Mouth/teeth dental problems: Mouth ulcers 0.9 1.5 4.0 1.2 -0.6 -2.0 -1.1 -0.6
Medication for cholesterol 2.7 4.1 10.9 -1.3 1.7 2.1 3.3 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 3.0 0.4 0.6 -1.7 -0.3 -0.4
Back pain experienced in last month 1.0 1.5 3.9 -2.0 -1.0 0.2 -0.5 1.5
Mineral and other dietary supplements 2.6 3.5 11.0 -3.3 -2.4 -0.5 0.0 0.5
Breast cancer (self-reported) 0.6 0.7 1.3 -0.9 -0.8 -0.7 -1.1 0.4
Asthma (self-reported) 0.3 0.6 1.2 0.4 -0.7 -1.1 -0.9 0.3
Osteoporosis (self-reported) 0.7 0.9 3.8 0.2 0.3 -0.5 2.0 -0.4
Osteoarthritis (self-reported) 1.5 1.9 6.9 2.6 0.3 1.0 0.1 -1.3
Medication: Aspirin 1.1 1.4 3.6 1.7 -1.9 0.1 -0.7 0.3
Medication: Gliclazide 2.1 2.3 7.5 -0.1 -2.7 -1.8 0.4 -0.9
Illnesses of father: None of the above (group 1) 2.7 3.4 16.3 -4.0 -0.1 -0.3 0.7 0.3
Smoking status: Current 0.3 0.4 1.9 0.3 -0.1 1.4 -0.3 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 3.5 -0.8 -1.9 0.3 -0.2 0.4
Whole body water mass 2.6 14.9 59.6 -7.7 1.6 -1.0 -0.6 3.3
Leg predicted mass (right) 2.4 12.9 54.2 -7.4 1.5 -0.7 -0.3 2.8
Arm fat mass (left) 0.7 3.1 13.6 -3.7 -0.3 -0.2 -0.5 1.2
Number of self-reported non-cancer illnesses 3.0 5.2 11.9 2.1 -3.5 -2.2 -1.7 -1.4
Average weekly champagne plus white wine intake 0.3 0.4 1.1 0.1 1.1 -0.7 -0.5 0.1
Miserableness 0.9 1.6 5.6 1.0 1.0 2.4 -0.4 0.4
Guilty feelings 1.5 2.2 7.0 1.5 -0.5 2.6 0.5 -1.1
Wears glasses or contact lenses 0.4 0.4 1.0 0.1 0.8 0.5 0.1 -1.0
Ever taken oral contraceptive pill 0.5 0.6 0.8 0.8 -0.7 -0.5 -0.8 0.9
Hearing aid user 0.5 0.5 1.5 -0.5 0.3 1.2 0.9 0.0
Mother’s age at death 3.8 4.8 9.9 -2.9 3.1 0.7 -0.5 2.2
Financial situation satisfaction 1.8 2.3 5.8 -1.8 -1.3 0.9 -0.3 2.4
Tinnitus: Yes, now most or all of the time 0.7 0.8 3.1 -1.8 -0.6 0.2 -0.5 0.5
Commuting to job workplace: Public transport 0.4 0.5 1.1 0.9 1.1 -0.2 0.7 -0.3
Eye problems/disorders: Glaucoma 0.5 0.6 1.8 0.8 1.4 0.3 -0.4 0.7
Medication: Blood pressure 1.6 3.1 7.1 2.0 -1.7 0.3 -2.7 1.1
Pain type(s) experienced in last month: Hip pain 1.1 1.4 3.7 0.4 -0.8 1.9 -1.5 0.5
Supplements: Fish oil (including cod liver oil) 2.1 2.7 6.1 2.5 2.5 0.6 -1.0 0.6
High cholesterol (Self-reported) 1.6 2.9 5.2 1.5 -2.1 -2.3 -1.4 -0.6
Medication: Bendroflumethiazide 0.8 1.3 3.5 1.9 -1.4 0.1 -0.1 -0.9
Medication: Paracetamol 1.0 1.5 4.5 2.1 -0.8 -0.4 -1.2 -0.8
Medication: Lisinopril 0.7 0.9 2.8 -0.5 -0.1 -1.7 -0.8 1.0
Medication: Atorvastatin 1.6 1.9 8.4 -0.3 -2.9 -0.8 -0.8 -0.3
Illnesses of father: High blood pressure 2.3 2.8 6.1 2.5 -0.4 -1.2 -1.7 -1.9
Alcohol drinker status: Never 0.3 0.4 0.8 0.5 -0.9 0.7 0.2 0.6
Ever smoked 0.6 1.0 1.9 1.2 0.8 -1.4 -1.1 0.3
Basal metabolic rate 2.4 13.2 54.5 -7.4 1.4 -0.9 -0.6 2.9
Leg fat percentage (left) 0.2 0.8 2.0 -0.3 -1.4 -0.1 -1.3 -0.4
Arm fat-free mass (left) 2.3 11.6 47.5 -6.9 1.3 -1.0 -0.5 2.7
Number of operations (self-reported) 0.3 0.4 0.8 0.8 -0.9 0.6 0.3 -0.3
Average weekly beer plus cider intake 2.6 3.7 6.8 2.5 -2.6 -0.6 -1.0 -2.1
Irritability 0.4 0.7 2.1 0.5 -1.5 -0.2 -0.5 0.8
Risk taking 1.3 1.9 5.1 2.3 -1.5 -0.3 0.1 -1.5
Ever had prostate specific antigen (PSA) test 1.2 1.4 6.6 -2.6 0.4 -0.3 0.3 -0.2
Fractured/broken bones in last 5 years 0.2 0.3 0.9 0.1 -0.3 0.9 -0.3 0.4
Age started oral contraceptive pill 0.6 0.8 1.8 1.4 -0.1 0.9 0.6 -0.9
Diastolic blood pressure, automated reading 0.3 1.0 3.6 0.6 -0.9 0.1 -1.9 0.4
Ever depressed for a whole week 0.5 0.6 1.7 0.5 -0.7 0.1 -0.9 1.3
Unable to work because of sickness or disability 0.7 0.9 2.2 0.1 -0.4 1.4 1.5 0.5
Commuting to job workplace: Cycle 2.1 2.5 6.3 0.6 1.5 2.5 0.1 1.9
Myopia 0.5 0.7 2.1 -0.7 -0.7 -1.5 -0.5 0.3
Vascular/heart problems diagnosed by doctor 1.3 3.5 8.8 -2.1 3.0 0.2 2.0 0.4
Cholesterol lowering medication 1.1 1.7 5.6 0.6 -0.5 -1.3 -2.4 0.8
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.4 -1.1 0.3 -1.2 -0.8 0.6
Pain experienced in last month 0.8 1.3 3.0 0.1 1.5 -0.2 -1.7 1.0
Supplements: Calcium 1.0 1.1 2.8 1.7 1.2 0.3 0.8 -0.7
Basal cell carcinoma (self-reported) 0.4 0.5 2.0 1.4 0.1 0.2 -0.4 0.2
Heart attack/myocardial infarction (self-reported) 1.2 1.5 5.4 0.6 -2.3 -0.6 -0.8 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.2 -0.8 1.5 0.6 0.4 1.4
Heart disease (siblings) 0.6 0.7 1.2 0.4 -0.7 1.1 -1.1 0.7
Alcohol drinker status: Previous 0.1 0.1 0.3 0.3 -0.6 0.2 0.0 -0.4
Pack years of smoking 0.9 1.3 2.8 -0.4 -1.7 -0.7 -1.0 -1.4
Impedance of whole body 1.4 7.2 24.1 4.9 -1.4 0.9 1.4 -2.6
Leg fat mass (left) 0.6 2.3 10.0 -3.2 -0.6 -0.3 -0.8 0.7
Arm predicted mass (left) 2.3 11.9 48.9 -7.0 1.2 -0.9 -0.8 2.8