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chr17:1,263,564-2,953,418

Best TWAS P=5.12e-14 · Best GWAS P=1.49e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SRR	0.27	0.48	lasso	1	0.48	3.5e-65	-7.0	7.0	3.3e-12	-0.94	0.07	0.93	FALSE
2	GTEx	Adipose Subcutaneous	SRR	0.16	0.16	lasso	9	0.18	1.9e-14	-7.3	7.5	5.9e-14	-0.94	0.00	1.00	FALSE
3	GTEx	Adipose Visceral Omentum	SRR	0.29	0.26	lasso	5	0.25	1.8e-13	-7.0	7.2	6.0e-13	-0.97	0.01	0.99	FALSE
4	GTEx	Adrenal Gland	SRR	0.38	0.37	lasso	6	0.38	8.1e-15	-7.0	7.4	9.6e-14	-0.94	0.01	0.99	FALSE
5	GTEx	Artery Aorta	SRR	0.33	0.33	lasso	2	0.32	6.1e-18	-7.0	7.1	1.7e-12	-0.94	0.03	0.97	FALSE
6	GTEx	Artery Coronary	SRR	0.44	0.28	lasso	8	0.26	2.5e-09	-7.3	7.5	9.2e-14	-0.98	0.01	0.99	FALSE
7	GTEx	Artery Tibial	SRR	0.22	0.23	lasso	4	0.24	3.9e-19	-7.3	7.2	4.9e-13	-0.99	0.00	1.00	FALSE
8	GTEx	Brain Caudate basal ganglia	SRR	0.26	0.03	lasso	3	0.02	8.6e-02	-5.7	6.4	1.9e-10	-0.85	0.02	0.85	FALSE
9	GTEx	Brain Cerebellar Hemisphere	SRR	0.37	0.24	lasso	7	0.22	2.1e-06	-7.0	6.5	6.4e-11	-0.93	0.01	0.98	FALSE
10	GTEx	Brain Cerebellum	SRR	0.26	0.20	lasso	3	0.21	8.7e-07	-7.0	7.0	2.2e-12	-0.91	0.02	0.95	FALSE
11	GTEx	Brain Frontal Cortex BA9	SRR	0.25	0.24	lasso	3	0.21	3.5e-06	-7.0	7.2	4.6e-13	-0.93	0.01	0.95	FALSE
12	GTEx	Breast Mammary Tissue	SRR	0.20	0.21	lasso	3	0.20	8.2e-11	-7.2	7.1	1.1e-12	-0.98	0.01	0.99	FALSE
13	GTEx	Breast Mammary Tissue (Female)	SRR	0.24	0.25	lasso	3	0.21	6.3e-07	-7.2	7.3	2.8e-13	-0.99	0.01	0.99	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	SRR	0.39	0.34	lasso	5	0.35	3.1e-12	-7.0	7.2	5.3e-13	-0.96	0.01	0.99	FALSE
15	GTEx	Cells Transformed fibroblasts	SRR	0.36	0.38	lasso	4	0.38	8.2e-30	-7.0	7.1	1.6e-12	-0.95	0.03	0.97	FALSE
16	GTEx	Colon Sigmoid	SRR	0.32	0.35	enet	8	0.32	9.2e-12	-7.0	7.1	1.0e-12	-0.98	0.01	0.99	FALSE
17	GTEx	Colon Transverse	SRR	0.28	0.21	lasso	5	0.19	1.6e-09	-7.0	6.9	5.2e-12	-0.96	0.01	0.99	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	SRR	0.40	0.35	lasso	3	0.36	1.1e-13	-7.0	6.9	4.0e-12	-0.94	0.02	0.98	FALSE
19	GTEx	Esophagus Mucosa	SRR	0.23	0.24	lasso	5	0.24	2.0e-16	-7.4	7.4	1.1e-13	-0.98	0.00	1.00	FALSE
20	GTEx	Esophagus Muscularis	SRR	0.30	0.39	lasso	3	0.38	3.4e-24	-7.0	7.0	3.0e-12	-0.95	0.02	0.98	FALSE
21	GTEx	Heart Atrial Appendage	SRR	0.35	0.30	lasso	7	0.29	1.4e-13	-7.4	7.0	3.1e-12	-0.98	0.00	1.00	FALSE
22	GTEx	Heart Left Ventricle	SRR	0.15	0.16	lasso	3	0.13	2.9e-07	-7.0	6.7	1.7e-11	-0.94	0.02	0.98	FALSE
23	GTEx	Lung	SRR	0.24	0.28	lasso	2	0.26	3.4e-20	-7.0	7.1	1.1e-12	-0.96	0.04	0.96	FALSE
24	GTEx	Muscle Skeletal	SRR	0.27	0.27	lasso	6	0.27	7.1e-27	-7.0	6.7	2.0e-11	-0.94	0.07	0.93	FALSE
25	GTEx	Nerve Tibial	SRR	0.15	0.13	lasso	3	0.13	2.9e-09	-7.3	7.2	5.0e-13	-0.99	0.01	0.99	FALSE
26	GTEx	Pancreas	SRR	0.13	0.17	lasso	3	0.15	5.2e-07	-7.4	7.3	2.4e-13	-0.99	0.00	1.00	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	SGSM2	0.37	0.35	enet	18	0.41	6.6e-24	4.9	-5.5	3.1e-08	0.31	1.00	0.00	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	SRR	0.18	0.16	enet	18	0.19	7.9e-11	-7.0	5.2	2.2e-07	-0.76	0.01	0.99	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	RP1-59D14.5	0.29	0.25	enet	23	0.30	1.3e-16	-4.8	-5.3	1.5e-07	0.41	1.00	0.00	FALSE
30	GTEx	Skin Sun Exposed Lower leg	SGSM2	0.50	0.47	enet	11	0.51	3.3e-48	4.9	-5.7	1.3e-08	0.28	1.00	0.00	FALSE
31	GTEx	Skin Sun Exposed Lower leg	SRR	0.13	0.15	lasso	4	0.14	2.0e-11	-7.0	6.9	4.6e-12	-0.95	0.03	0.97	FALSE
32	GTEx	Skin Sun Exposed Lower leg	TSR1	0.20	0.05	enet	24	0.06	5.4e-06	4.9	-5.4	6.1e-08	0.32	0.86	0.03	FALSE
33	GTEx	Skin Sun Exposed Lower leg	RP1-59D14.5	0.32	0.28	lasso	5	0.30	1.8e-25	4.9	-5.5	3.1e-08	0.27	1.00	0.00	FALSE
34	GTEx	Spleen	SRR	0.21	0.10	lasso	4	0.04	3.1e-02	-7.0	7.3	2.5e-13	-0.95	0.03	0.81	FALSE
35	GTEx	Stomach	SRR	0.27	0.30	lasso	7	0.28	7.1e-14	-7.4	7.4	1.7e-13	-1.00	0.00	1.00	FALSE
36	GTEx	Testis	SMG6	0.28	0.07	enet	39	0.14	1.2e-06	-7.0	-6.2	4.8e-10	0.73	0.01	0.98	FALSE
37	GTEx	Testis	SRR	0.13	0.12	lasso	2	0.09	6.6e-05	-6.7	6.8	7.9e-12	-0.96	0.01	0.98	FALSE
38	GTEx	Thyroid	SRR	0.26	0.27	lasso	4	0.25	2.0e-19	-7.0	7.0	2.1e-12	-0.95	0.01	0.99	FALSE
39	GTEx	Vagina	SRR	0.18	0.13	lasso	2	0.11	1.6e-03	-7.2	7.0	2.4e-12	-0.95	0.02	0.84	FALSE
40	GTEx	Whole Blood	SRR	0.09	0.03	enet	8	0.02	4.5e-03	-7.0	6.3	2.5e-10	-0.92	0.01	0.99	FALSE
41	METSIM	Adipose	SRR	0.07	0.07	enet	21	0.06	4.4e-09	-7.0	6.9	6.0e-12	-0.90	0.01	0.99	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	SRR	0.25	0.39	lasso	3	0.39	5.6e-53	-7.0	7.1	8.8e-13	-0.96	0.07	0.93	FALSE
43	YFS	Blood	SRR	0.17	0.22	lasso	7	0.23	2.5e-72	-7.0	7.2	4.8e-13	-0.97	0.06	0.94	FALSE
44	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SRR	0.11	0.09	lasso	4	0.10	6.8e-09	-7.0	6.5	8.1e-11	-0.91	0.01	0.99	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	SRR	0.16	0.16	lasso	5	0.16	2.3e-32	-7.3	7.3	2.6e-13	-0.99	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SRR	0.15	0.11	blup	61	0.07	4.0e-04	-7.0	6.8	1.3e-11	-0.80	0.01	0.96	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	SRR	0.32	0.24	lasso	3	0.23	1.5e-13	-7.0	6.9	4.1e-12	-0.94	0.02	0.98	FALSE
48	The Cancer Genome Atlas	Esophageal Carcinoma	SRR	0.32	0.13	lasso	2	0.16	9.2e-06	-6.7	6.7	2.6e-11	-0.95	0.07	0.89	FALSE
49	The Cancer Genome Atlas	Glioblastoma Multiforme	SRR	0.24	0.16	lasso	1	0.13	9.0e-05	-7.0	7.0	3.3e-12	-0.94	0.00	0.97	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SRR	0.10	0.10	lasso	2	0.09	1.0e-10	-7.0	7.1	8.9e-13	-0.97	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SRR	0.30	0.40	lasso	7	0.39	8.5e-47	-7.3	7.5	5.1e-14	-0.99	0.00	1.00	TRUE
52	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SRR	0.22	0.23	lasso	2	0.21	2.3e-12	-7.0	7.0	2.1e-12	-0.95	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	SRR	0.29	0.26	lasso	2	0.27	1.9e-30	-7.3	7.2	6.6e-13	-0.99	0.00	1.00	FALSE
54	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SRR	0.08	0.09	enet	3	0.08	1.7e-04	-7.0	7.2	8.2e-13	-0.97	0.00	0.97	FALSE
55	The Cancer Genome Atlas	Lung Adenocarcinoma	SRR	0.14	0.18	lasso	2	0.18	4.3e-21	-7.0	7.2	8.5e-13	-0.97	0.01	0.99	FALSE
56	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SRR	0.11	0.12	lasso	2	0.12	4.3e-13	-7.0	7.0	2.8e-12	-0.94	0.02	0.98	FALSE
57	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SRR	0.16	0.20	lasso	3	0.20	2.8e-13	-7.4	7.5	6.4e-14	-0.99	0.00	1.00	FALSE
58	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SRR	0.34	0.30	lasso	4	0.30	2.9e-13	-7.0	7.0	2.3e-12	-0.96	0.01	0.99	FALSE
59	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SRR	0.27	0.19	enet	5	0.21	8.9e-09	-7.4	7.3	2.9e-13	-0.99	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	SRR	0.30	0.35	lasso	3	0.36	7.5e-39	-7.0	7.2	6.9e-13	-0.97	0.01	0.99	FALSE
61	The Cancer Genome Atlas	Rectum Adenocarcinoma	SRR	0.52	0.32	lasso	3	0.40	1.7e-10	-7.0	5.7	1.3e-08	-0.90	0.00	0.99	FALSE
62	The Cancer Genome Atlas	Soft Tissue Sarcoma	SRR	0.20	0.18	lasso	2	0.20	8.8e-12	-7.0	7.2	4.8e-13	-0.98	0.00	1.00	FALSE
63	The Cancer Genome Atlas	Skin Cutaneous Melanoma	SRR	0.16	0.03	blup	61	0.02	8.7e-02	-6.7	7.2	4.5e-13	-0.76	0.01	0.58	FALSE
64	The Cancer Genome Atlas	Stomach Adenocarcinoma	SRR	0.21	0.15	enet	11	0.16	1.1e-11	-7.3	6.4	2.0e-10	-0.93	0.00	1.00	FALSE
65	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SGSM2	0.13	0.01	blup	81	0.01	1.1e-01	5.8	-7.3	3.2e-13	0.67	0.02	0.40	FALSE
66	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SRR	0.35	0.07	enet	11	0.14	1.1e-05	-7.3	5.2	1.5e-07	-0.86	0.00	0.99	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	SRR	0.56	0.50	lasso	4	0.50	5.2e-55	-7.0	7.1	1.5e-12	-0.94	0.03	0.97	FALSE