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chr17:34,157,655-35,675,511

Best TWAS P=2.45e-11 · Best GWAS P=1.93e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
52	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DHRS11	0.06	0.06	blup	12	0.04	2.0e-02	-6.3	6.7	2.4e-11	-0.96	0.00	0.69	TRUE
42	The Cancer Genome Atlas	Esophageal Carcinoma	DHRS11	0.12	0.12	blup	13	0.12	1.5e-04	-6.3	6.7	2.9e-11	-0.88	0.00	0.94	FALSE
49	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZNHIT3	0.03	0.03	enet	4	0.03	1.8e-04	-6.4	6.3	2.5e-10	-0.99	0.00	0.98	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	DHRS11	0.05	0.11	enet	6	0.10	7.4e-12	-6.3	6.3	3.1e-10	-0.98	0.00	1.00	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	GGNBP2	0.12	0.12	lasso	2	0.09	4.9e-04	-6.2	-6.3	3.3e-10	0.98	0.01	0.96	FALSE
27	GTEx	Heart Left Ventricle	DHRS11	0.13	0.10	lasso	1	0.08	3.3e-05	-6.3	6.3	3.8e-10	-0.96	0.01	0.99	FALSE
36	GTEx	Testis	GGNBP2	0.19	0.19	lasso	1	0.15	3.8e-07	-6.3	-6.3	3.8e-10	0.96	0.01	0.99	FALSE
43	The Cancer Genome Atlas	Esophageal Carcinoma	ZNHIT3	0.11	0.11	lasso	4	0.09	6.2e-04	-6.4	6.3	4.1e-10	-0.98	0.00	0.89	FALSE
7	GTEx	Artery Aorta	DHRS11	0.10	0.07	lasso	5	0.06	2.7e-04	-6.2	6.2	4.2e-10	-0.99	0.01	0.98	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DHRS11	0.04	0.04	lasso	2	0.04	3.1e-05	-6.2	6.2	4.4e-10	-0.99	0.00	0.99	FALSE
37	GTEx	Thyroid	GGNBP2	0.07	0.06	lasso	2	0.04	2.8e-04	-6.2	-6.2	5.2e-10	0.98	0.02	0.98	FALSE
41	The Cancer Genome Atlas	Colon Adenocarcinoma	MRM1	0.06	0.06	enet	4	0.05	9.4e-04	-6.3	-6.2	5.3e-10	0.98	0.00	0.94	FALSE
48	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	GGNBP2	0.05	0.04	lasso	2	0.01	8.1e-02	-6.1	-6.2	5.3e-10	0.97	0.01	0.85	FALSE
11	GTEx	Brain Caudate basal ganglia	DHRS11	0.18	0.12	lasso	4	0.02	9.2e-02	-6.0	6.2	6.5e-10	-0.98	0.02	0.86	FALSE
13	GTEx	Brain Cerebellum	DHRS11	0.33	0.23	lasso	4	0.20	1.9e-06	-6.2	6.2	7.6e-10	-0.98	0.01	0.98	FALSE
39	NTR	Blood	GGNBP2	0.03	0.02	bslmm	331	0.02	7.7e-07	-5.2	-6.0	1.6e-09	0.74	0.10	0.90	FALSE
29	GTEx	Lung	DHRS11	0.09	0.08	lasso	5	0.10	3.7e-08	-5.9	6.0	1.9e-09	-0.96	0.01	0.99	FALSE
8	GTEx	Artery Tibial	GGNBP2	0.12	0.12	enet	15	0.12	1.2e-09	-6.2	-6.0	2.0e-09	0.96	0.02	0.98	FALSE
6	GTEx	Artery Aorta	GGNBP2	0.13	0.12	lasso	4	0.12	2.4e-07	-6.2	-6.0	2.1e-09	0.95	0.02	0.98	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	DHRS11	0.18	0.20	lasso	3	0.15	8.8e-05	-6.0	6.0	2.1e-09	-0.97	0.02	0.96	FALSE
31	GTEx	Muscle Skeletal	DHRS11	0.09	0.08	lasso	3	0.09	9.3e-09	-5.9	6.0	2.7e-09	-0.96	0.04	0.96	FALSE
12	GTEx	Brain Cerebellar Hemisphere	CTB-75G16.3	0.27	0.14	lasso	4	0.05	1.8e-02	-6.4	-5.9	2.9e-09	0.98	0.02	0.83	FALSE
14	GTEx	Brain Cortex	DHRS11	0.23	0.18	enet	24	0.18	8.5e-06	-6.2	5.9	3.3e-09	-0.93	0.02	0.98	FALSE
20	GTEx	Cells Transformed fibroblasts	DHRS11	0.11	0.08	lasso	2	0.08	2.7e-06	-6.2	5.9	3.5e-09	-0.96	0.01	0.99	FALSE
23	GTEx	Esophagus Mucosa	GGNBP2	0.16	0.16	enet	15	0.18	3.1e-12	-5.2	-5.9	3.6e-09	0.90	0.10	0.90	FALSE
33	GTEx	Pancreas	GGNBP2	0.15	0.09	lasso	2	0.07	5.1e-04	-6.1	-5.8	4.9e-09	0.92	0.02	0.98	FALSE
51	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZNHIT3	0.06	0.03	enet	2	0.04	1.3e-03	-5.5	5.8	5.0e-09	-0.93	0.01	0.95	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GGNBP2	0.04	0.04	enet	3	0.04	6.3e-05	4.7	-5.8	6.5e-09	0.91	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	GGNBP2	0.04	0.04	enet	6	0.05	1.4e-05	-6.1	-5.7	9.3e-09	0.88	0.01	0.97	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNHIT3	0.05	0.03	enet	4	0.04	4.7e-05	4.9	5.7	1.0e-08	-0.90	0.01	0.99	FALSE
10	GTEx	Artery Tibial	MYO19	0.12	0.11	lasso	6	0.13	4.1e-10	4.7	5.7	1.6e-08	-0.88	0.04	0.96	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DHRS11	0.22	0.24	bslmm	311	0.25	1.6e-30	-6.2	5.6	1.7e-08	-0.92	0.01	0.99	FALSE
35	GTEx	Stomach	GGNBP2	0.13	0.06	lasso	3	0.06	5.9e-04	-5.2	-5.6	1.8e-08	0.89	0.03	0.94	FALSE
21	GTEx	Colon Transverse	GGNBP2	0.15	0.15	enet	13	0.11	4.8e-06	-6.2	-5.6	2.0e-08	0.97	0.02	0.98	FALSE
40	YFS	Blood	DHRS11	0.05	0.06	lasso	7	0.06	2.5e-18	-5.3	5.6	2.1e-08	-0.85	0.66	0.34	FALSE
24	GTEx	Esophagus Mucosa	DHRS11	0.12	0.08	lasso	2	0.06	5.1e-05	4.9	5.6	2.7e-08	-0.88	0.03	0.96	FALSE
26	GTEx	Heart Atrial Appendage	MYO19	0.13	0.12	lasso	1	0.11	1.1e-05	-5.5	5.5	2.9e-08	-0.88	0.03	0.96	FALSE
34	GTEx	Skin Sun Exposed Lower leg	GGNBP2	0.11	0.06	enet	11	0.10	1.3e-08	-5.2	-5.5	3.0e-08	0.89	0.05	0.95	FALSE
38	GTEx	Whole Blood	GGNBP2	0.08	0.01	lasso	4	0.01	3.6e-02	-5.5	-5.5	3.3e-08	0.88	0.07	0.70	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	DHRS11	0.14	0.08	enet	3	0.07	3.2e-03	-5.5	5.5	3.5e-08	-0.90	0.03	0.82	FALSE
15	GTEx	Brain Frontal Cortex BA9	DHRS11	0.34	0.26	enet	19	0.25	2.5e-07	-6.2	5.5	3.9e-08	-0.91	0.02	0.98	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	GGNBP2	0.13	0.15	lasso	2	0.13	5.5e-05	-5.5	-5.5	4.1e-08	0.90	0.03	0.91	FALSE
28	GTEx	Lung	GGNBP2	0.08	0.01	enet	8	0.01	3.3e-02	4.9	-5.5	4.5e-08	0.87	0.03	0.96	FALSE
25	GTEx	Esophagus Muscularis	DHRS11	0.14	0.08	lasso	5	0.08	8.2e-06	-5.5	5.5	4.7e-08	-0.86	0.08	0.91	FALSE
3	GTEx	Adipose Subcutaneous	GGNBP2	0.10	0.11	enet	9	0.11	3.5e-09	4.7	-5.4	6.8e-08	0.85	0.18	0.82	FALSE
16	GTEx	Brain Hypothalamus	DHRS11	0.24	0.12	lasso	2	0.12	1.1e-03	-5.5	5.4	7.3e-08	-0.90	0.03	0.89	FALSE
30	GTEx	Muscle Skeletal	GGNBP2	0.08	0.06	enet	14	0.05	2.5e-05	-5.2	-5.3	1.2e-07	0.82	0.08	0.92	FALSE
5	GTEx	Adipose Visceral Omentum	GGNBP2	0.13	0.12	enet	11	0.13	1.9e-07	-5.3	-5.3	1.4e-07	0.82	0.10	0.89	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	GGNBP2	0.02	0.02	enet	4	0.02	6.0e-03	-5.2	-5.3	1.4e-07	0.82	0.02	0.63	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MYO19	0.05	0.05	lasso	2	0.05	8.4e-07	-5.2	5.2	1.7e-07	-0.82	0.63	0.37	FALSE
4	GTEx	Adipose Subcutaneous	MYO19	0.07	0.05	enet	10	0.03	1.3e-03	4.6	5.2	1.7e-07	-0.79	0.06	0.92	FALSE
9	GTEx	Artery Tibial	DHRS11	0.14	0.08	enet	11	0.11	7.1e-09	-5.9	5.2	1.9e-07	-0.88	0.04	0.96	FALSE
32	GTEx	Nerve Tibial	GGNBP2	0.10	0.04	lasso	3	0.05	2.4e-04	4.7	-5.2	2.0e-07	0.82	0.07	0.92	FALSE