Hub : Genes

KCNH2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.343	0.114	5.8e-03	0.089	NA	0.101	NA	0.122	2.8e-03	NA	1.5e-03	NA	5.0e-04
2	GTEx	Brain Cerebellum	0.350	0.080	4.3e-05	0.205	NA	0.284	NA	0.279	1.1e-06	NA	4.8e-09	NA	6.8e-09
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.126	0.054	7.1e-04	0.030	0.072	0.067	NA	0.054	7.3e-03	6.4e-05	1.1e-04	NA	4.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.2	0.2	-0.5	-0.5	0.2
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	0.2	-0.2	-0.3
Depressed Affect (Nagel 2018)	2.5	5.2	9.2	2.5	3.0	0.6
Depression (Nagel 2018)	0.7	1.0	1.6	1.2	1.3	-0.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.8	1.0	0.6	1.4
Neuroticism (Nagel 2018)	0.9	2.1	4.6	1.3	2.1	-0.3
Schizophrenia (2018)	0.1	0.2	0.4	0.6	0.1	-0.5
Schizophrenia vs Biploar Disorder	0.5	0.7	1.8	0.2	0.5	-1.3
Worry (Nagel 2018)	0.4	0.8	1.7	0.7	1.3	-0.5
Alzheimer’s Disease (in mother)	0.6	0.7	1.5	-0.4	-0.6	1.2
Alzheimer’s Disease (in father)	0.5	0.5	0.9	0.3	0.7	-0.9
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	-0.1	-0.1	0.6
Crohns Disease (2017)	1.0	2.1	4.1	-2.0	-0.8	-1.3
Irritable Bowel Disease (IBD)	0.8	1.8	3.2	-1.4	-0.6	-1.8
Ulcerative Colitis (UC)	0.4	0.8	2.0	-0.3	-0.6	-1.4
Major Depression (MDD)	0.2	0.3	0.6	-0.2	0.4	0.8
Reaction Time	0.4	0.9	2.5	0.2	1.6	-0.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.3	0.7	0.3	1.5
Breast Cancer	0.7	1.6	3.9	-0.6	-0.7	2.0
Ovarian Cancer	0.7	0.9	1.1	-1.1	-0.8	0.9
Prostate Cancer	0.4	0.6	1.1	-1.1	-0.9	-0.0
Age at First Birth	0.3	0.4	0.7	-0.8	0.0	-0.8
Bipolar Disorder (2011)	0.3	0.3	0.5	0.7	-0.5	0.0
Body Mass Index (BMI) (2010)	3.6	4.9	8.2	-2.5	-2.9	-0.3
Coronary Artery Disease (CAD)	0.9	1.1	1.8	-1.4	-1.2	0.0
Crohns Disease (2012)	0.3	0.5	0.9	-0.4	0.6	-1.0
Mean Putamen Volume	0.3	0.4	0.6	0.7	0.7	0.2
Fasting Glucose	0.2	0.2	0.4	-0.6	-0.4	0.2
HbA1C	0.2	0.3	0.5	-0.2	-0.4	0.7
HDL Cholesterol	3.5	5.8	8.4	2.9	2.9	-0.8
LDL Cholesterol	0.1	0.2	0.3	-0.6	-0.5	-0.1
Lupus	0.3	0.5	1.3	0.0	-0.4	1.1
Neuroticism (2016)	1.2	1.7	4.6	0.8	2.1	-0.2
Primary Biliary Cirrhosis	1.1	1.6	2.0	-1.1	-1.3	-1.4
Rheumatoid Arthritis	0.1	0.1	0.2	0.3	0.4	-0.2
Schizophrenia (2014)	0.5	1.0	1.5	-0.7	-1.0	-1.2
Triglycerides	1.0	1.7	2.8	-1.7	-1.5	0.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.5	-0.9	-1.2	0.2
Ulcerative Colitis	0.1	0.1	0.2	0.2	-0.3	-0.4
Blood Eosinophil Count	0.5	3.6	7.2	-1.9	0.4	-2.7
Blood Platelet Count	1.3	14.6	18.7	-4.3	-4.3	-2.5
Blood Red Count	0.3	2.5	7.3	-0.1	-0.5	2.7
Blood White Count	0.1	1.0	1.4	-1.2	-1.0	0.8
Heel T-Score	0.1	0.7	1.3	-1.2	-0.7	-0.4
BMI	3.2	18.5	35.8	-4.4	-6.0	0.5
Height	2.4	45.5	87.6	-6.8	-9.4	-1.5
Waist Hip Ratio (WHR)	0.4	1.9	2.5	1.6	1.5	0.9
Systolic Blood Pressure	1.7	8.5	25.0	0.2	-0.6	5.0
Smoking Status	2.8	6.7	10.6	-3.1	-3.3	-0.1
Allergy or Eczema	2.9	7.6	11.4	-3.4	-2.7	-2.0
Cardiovascular Disease	0.6	2.1	6.1	0.3	0.2	2.5
Hypothyroidism (self reported)	0.2	0.5	0.9	-1.0	-0.8	-0.3
Respiratory disease	1.7	3.8	6.0	-2.5	-1.6	-1.6
Type 2 Diabetes (T2D) (2018)	2.5	4.7	7.2	-2.7	-2.2	-1.4
Lung FEV1/FVC ratio	0.1	0.5	1.1	-0.5	-0.6	1.0
Lung FVC	1.1	5.5	9.2	2.4	1.2	3.0
Neuroticism	0.5	1.3	2.6	0.9	1.6	-0.6
Chronotype (morning person)	2.4	5.5	11.6	-1.8	-3.4	1.2
Hair Pigment	0.0	0.2	0.2	-0.5	-0.0	-0.5
Tanning	0.3	4.2	9.9	-1.4	-0.8	-3.2
Hand grip strength (left)	0.9	2.5	5.1	-0.7	-1.3	2.2
Number of treatments/medications taken	1.8	3.2	5.4	-2.3	-2.0	0.2
Average weekly spirits intake	1.4	1.7	1.8	-1.3	-1.4	-1.2
Sensitivity / hurt feelings	0.4	0.7	1.8	-0.6	0.1	-1.3
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.2	0.5	0.7	-1.1
Hearing difficulty/problems: Yes	0.7	1.1	2.0	-1.4	-1.1	0.1
Relative age of first facial hair	0.6	1.2	2.4	-0.9	-0.6	-1.5
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.1	-1.1	-1.5	0.2
Ever used hormone-replacement therapy (HRT)	1.3	1.6	2.3	-1.5	-1.5	-0.4
Ever had hysterectomy (womb removed)	0.2	0.3	0.7	0.3	0.3	-0.8
Systolic blood pressure, automated reading	2.1	6.0	16.3	0.9	-1.0	4.0
Eye problems/disorders: Diabetes related eye disease	11.1	12.2	15.1	-3.9	-2.6	-3.8
Angina	1.5	2.0	3.1	-1.5	-0.7	-1.8
Medication for hormone replacement therapy	2.8	3.1	4.8	-1.8	-2.2	-1.2
Vitamin and mineral supplements	0.1	0.1	0.2	0.2	-0.5	0.2
Supplements: Zinc	0.0	0.0	0.1	-0.0	-0.1	-0.3
Medication: Co-codamol	0.5	0.5	0.9	-0.7	-0.6	-0.9
Medication: Metformin	2.0	2.8	3.9	-1.8	-2.0	-1.1
Diabetes (father)	0.2	0.3	0.7	0.2	-0.3	0.8
Diabetes (mother)	5.0	6.4	8.1	-2.5	-2.3	-2.8
Severe depression (siblings)	1.2	1.4	4.0	-0.0	-0.3	2.0
Pack years adult smoking proportion	0.9	1.3	2.0	-0.9	-1.4	1.1
Impedance of leg (right)	7.1	34.3	73.7	5.2	8.6	1.3
Leg fat-free mass (left)	8.6	45.6	90.6	-6.8	-9.5	-0.8
Trunk fat percentage	0.2	1.0	1.5	-1.2	-1.2	-0.2
Hand grip strength (right)	1.1	3.0	3.9	-1.9	-2.0	1.3
Townsend deprivation index at recruitment	0.6	0.9	1.4	-1.0	-0.4	-1.2
Current tobacco smoking	3.0	4.9	6.6	-2.6	-2.2	-1.8
Average weekly fortified wine intake	0.6	0.7	1.1	0.6	0.8	-1.1
Maternal smoking around birth	0.5	0.7	1.0	1.0	0.9	0.6
Fed-up feelings	0.2	0.4	0.9	0.3	1.0	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.3	0.7	1.1	-1.2
Relative age voice broke	1.2	1.9	3.3	-1.8	-0.6	-1.4
Taking other prescription medications	0.7	1.1	2.3	-0.9	-1.5	0.3
Age when periods started (menarche)	1.1	2.6	5.1	1.5	2.2	-0.7
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	3.4	-0.8	-1.2	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	2.8	-1.5	-1.7	0.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.3	1.0	0.5	1.2
Qualifications: CSEs or equivalent	0.1	0.2	0.3	-0.4	0.5	-0.3
Serious illness, injury or assault to yourself	0.5	0.6	1.3	-0.5	-1.2	-0.6
High blood pressure	1.1	3.0	7.3	1.2	0.3	2.7
Hayfever, allergic rhinitis or eczema	1.7	3.8	5.6	-2.4	-1.9	-1.5
Multivitamins +/- minerals	0.5	0.6	1.4	0.5	1.2	-0.3
Stomach or abdominal pain in last month	3.0	3.7	6.6	-2.6	-2.1	-0.3
Supplements: Glucosamine	2.8	3.6	9.1	-1.3	0.2	-3.0
Diverticular disease/diverticulitis (self-reported)	0.0	0.1	0.1	0.0	-0.2	-0.3
Medication: Atenolol	0.1	0.1	0.2	-0.5	-0.2	-0.3
Medication: Levothyroxine sodium	0.1	0.1	0.3	0.5	0.3	0.3
Sitting height	3.3	23.8	41.0	-5.5	-6.4	-0.8
Chronic bronchitis/emphysema (father)	1.0	1.2	2.3	-0.8	-0.8	-1.5
High blood pressure (mother)	1.0	1.4	1.6	-1.0	-1.3	-1.3
Body mass index (BMI)	2.8	11.9	24.7	-3.3	-5.0	0.2
Impedance of leg (left)	7.4	35.7	76.8	5.4	8.8	1.1
Leg predicted mass (left)	8.6	45.5	90.4	-6.7	-9.5	-0.9
Trunk fat mass	2.1	8.9	16.7	-3.1	-4.1	-0.3
Waist circumference	3.1	11.3	22.9	-3.3	-4.8	-0.3
Number of incorrect matches in round	3.2	5.4	5.9	2.4	2.4	-2.1
Past tobacco smoking	1.1	2.0	3.6	1.5	1.9	0.5
Alcohol usually taken with meals	0.4	0.6	1.1	0.7	1.1	-0.4
Nervous feelings	0.6	1.1	2.1	0.6	1.4	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	-0.3	0.5	-1.1
Hearing difficulty/problems with background noise	0.7	1.2	1.9	-1.4	-1.3	0.0
Hair/balding pattern: Pattern 2	0.9	1.1	1.5	1.2	1.2	0.6
Had menopause	1.2	1.5	2.6	1.2	0.7	1.6
Had other major operations	0.1	0.2	0.4	0.3	-0.6	0.1
Forced vital capacity (FVC)	0.9	3.4	5.1	-0.7	-2.3	2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.9	-0.3	-0.6	0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.2	0.3	1.5	-0.0
Qualifications: None of the above	0.2	0.3	0.7	0.4	0.4	-0.8
Financial difficulties in last 2 years	0.5	0.7	1.6	0.0	-0.6	-1.3
Mouth/teeth dental problems	1.0	1.6	2.4	1.6	1.5	0.1
Heart attack	3.6	4.6	7.8	-2.8	-2.3	-0.7
Allergy	3.0	7.0	8.4	2.9	2.6	2.4
Pain all over the body in last month	0.1	0.1	0.3	-0.2	-0.6	-0.3
Diabetes (self-reported)	3.5	5.4	7.1	-2.7	-2.3	-1.9
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.1	-1.4	-1.0	-0.1
Medication: Ramipril	0.6	0.8	1.7	-0.8	0.1	-1.3
Medication: Simvastatin	0.5	0.7	2.0	-0.4	0.1	-1.4
Fluid intelligence score	0.4	0.8	1.9	0.7	0.1	1.4
Illnesses of siblings	0.6	0.8	1.2	1.0	0.5	-1.1
Neuroticism score	0.3	0.6	1.1	-0.3	0.8	-1.1
Weight	6.2	30.4	60.2	-5.6	-7.8	-0.2
Impedance of arm (right)	4.8	22.3	47.6	4.3	6.9	0.8
Arm fat percentage (right)	0.7	2.7	5.8	-1.5	-2.4	0.3
Trunk fat-free mass	8.8	50.6	104.0	-6.9	-10.2	-0.5
Hip circumference	4.2	18.2	32.6	-4.5	-5.7	-1.3
Time employed in main current job	0.6	0.7	1.2	-1.1	-1.0	0.2
Alcohol intake versus 10 years previously	0.6	0.9	2.5	0.1	0.2	-1.6
Father’s age at death	0.2	0.3	0.5	-0.4	-0.7	-0.3
Worrier / anxious feelings	0.1	0.3	0.7	-0.1	-0.3	0.9
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	3.3	-1.8	-1.0	-1.1
Falls in the last year	0.3	0.5	1.1	-1.0	-0.2	-0.6
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.2	-0.4	0.8
Number of live births	0.3	0.4	0.6	-0.4	-0.8	0.6
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	7.1	-0.6	-1.9	2.7
Pulse rate	0.1	0.2	0.6	-0.2	-0.0	-0.8
Happiness	0.2	0.2	0.4	-0.6	-0.4	-0.4
Noisy workplace	0.6	0.7	0.8	0.8	0.9	0.8
Qualifications: A levels/AS levels or equivalent	1.0	2.3	6.4	0.6	0.3	2.5
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.1	5.0	-2.0	-2.2	0.6
Mouth/teeth dental problems: Dentures	1.4	2.4	3.7	-1.5	-1.9	-1.1
Asthma	1.9	3.8	7.5	-1.8	-0.7	-2.7
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.3	2.3	-1.1	-1.5	0.7
Medication: Cholesterol lowering	0.3	0.5	1.3	-0.4	0.1	-1.1
Depression (self-reported)	0.3	0.4	0.4	0.6	0.6	-0.6
Medication: Lansoprazole	1.8	2.0	6.0	-0.1	0.1	2.5
Prospective memory result	0.2	0.3	0.4	-0.0	-0.6	-0.6
Lung cancer (father)	0.1	0.1	0.2	0.1	-0.4	-0.2
Illnesses of mother	0.9	1.1	1.3	1.0	1.1	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	6.6	0.1	-1.4	2.6
Pulse wave Arterial Stiffness index	0.8	1.0	1.3	-0.9	-1.1	0.9
Impedance of arm (left)	4.7	22.0	49.1	4.1	7.0	0.1
Arm fat mass (right)	3.2	13.0	26.2	-3.6	-5.1	-0.0
Trunk predicted mass	8.8	50.1	104.0	-6.8	-10.2	-0.4
Standing height	2.6	25.7	47.5	-5.4	-6.9	-0.5
Length of working week for main job	0.5	0.6	0.7	-0.9	-0.8	0.7
Exposure to tobacco smoke at home	1.1	1.2	2.7	-0.8	-0.4	-1.7
Breastfed as a baby	0.8	1.0	1.5	-0.8	-0.9	-1.2
Tense / ‘highly strung’	0.4	0.6	1.6	-0.4	0.1	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.0	0.2	0.7	-1.7
Hair/balding pattern: Pattern 4	1.3	3.1	3.6	-1.9	-1.6	-1.8
Birth weight of first child	1.9	3.4	5.9	-0.7	-2.4	2.0
Peak expiratory flow (PEF)	1.5	3.6	9.7	-0.5	-0.8	3.1
Pulse wave reflection index	1.6	1.9	3.5	-1.5	-1.9	0.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.3	0.7	1.2	-0.6
Loud music exposure frequency	0.6	0.6	0.8	0.8	0.9	0.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	-0.4	-0.3	0.9
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.4	-0.3	0.3	-1.2
Blood clot in the leg (DVT)	2.6	3.4	3.5	-1.8	-1.9	-1.9
Medication: Paracetamol	0.6	1.1	2.3	-0.7	-1.5	0.6
Headache pain in last month	0.0	0.1	0.1	0.3	0.2	0.3
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	-0.1	-0.6	0.4
Glaucoma (self-reported)	0.6	0.8	2.2	-0.0	-1.5	0.3
Gout (self-reported)	0.8	1.2	3.4	0.1	-0.1	-1.9
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	-0.3	-0.1	0.1
Medication: Amlodipine	0.1	0.1	0.3	0.6	-0.1	-0.1
Medication: Ventolin 100micrograms inhaler	1.5	1.9	2.2	-1.3	-1.5	-1.3
Birth weight	0.2	0.5	0.9	-0.7	-0.9	-0.4
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.3	-1.1	-1.0	-0.4
High blood pressure (siblings)	0.5	0.7	1.8	-0.3	0.5	1.3
Forced vital capacity (FVC), Best measure	0.8	2.9	7.0	0.6	-1.1	2.6
Body fat percentage	0.2	0.7	1.2	-0.9	-1.1	0.1
Leg fat percentage (right)	0.1	0.4	0.5	-0.5	-0.7	0.7
Arm fat-free mass (right)	8.5	43.5	86.7	-6.5	-9.3	-1.0
Exposure to tobacco smoke outside home	0.1	0.2	0.5	-0.7	-0.3	0.1
Comparative body size at age 10	1.5	4.1	6.4	-1.9	-2.5	1.5
Number of full brothers	0.3	0.4	0.6	-0.8	-0.3	0.7
Worry too long after embarrassment	0.3	0.6	1.3	-0.6	-0.2	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	3.6	1.6	1.9	-0.5
Wheeze or whistling in the chest in last year	0.4	0.7	1.3	-0.6	-0.6	1.1
Number of children fathered	1.3	1.4	1.9	-1.4	-1.4	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.2	0.9	1.5	-1.1
Age at first live birth	0.7	1.2	3.0	-0.1	1.7	-0.8
Pulse wave peak to peak time	0.3	0.3	0.6	0.3	0.4	-0.8
Health satisfaction	2.2	2.9	5.4	-2.3	-1.1	-1.4
Shortness of breath walking on level ground	0.1	0.2	0.3	0.4	0.1	-0.6
Qualifications: College or University degree	0.1	0.2	0.3	0.0	0.6	0.6
Eye problems/disorders: None of the above	5.1	5.9	7.4	2.7	2.4	2.1
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.8	-0.0	0.3	0.9
Emphysema/chronic bronchitis	0.7	0.8	1.7	1.3	0.7	0.0
Medication for pain relief, constipation, heartburn	1.9	3.3	5.7	2.0	2.4	-0.2
Neck or shoulder pain in last month	0.8	1.2	2.3	-1.5	-0.4	-1.0
Medication: Blood pressure	0.0	0.1	0.2	-0.1	0.4	0.0
Angina (self-reported)	1.3	1.7	2.9	-1.4	-0.5	-1.7
Migraine (self-reported)	0.1	0.1	0.3	-0.5	0.1	-0.0
Medication: Ibuprofen	1.2	1.4	2.3	-0.8	-1.5	1.2
Medication: Allopurinol	2.1	2.8	8.4	-0.1	0.1	-2.9
Medication: Omeprazole	1.8	2.1	3.4	-1.7	-1.9	0.2
Medication: Seretide 50 evohaler	2.4	2.7	4.4	-2.1	-1.0	-1.7
Mean time to correctly identify matches	0.4	0.7	1.6	0.4	1.3	-0.7
Heart disease (mother)	0.3	0.3	0.5	-0.5	-0.7	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.3	-1.1	-0.8	1.1
Whole body fat mass	2.5	10.4	20.2	-3.3	-4.5	-0.1
Leg fat mass (right)	2.4	9.3	17.9	-3.2	-4.2	0.1
Arm predicted mass (right)	8.4	43.0	85.6	-6.5	-9.2	-0.9
Pulse rate, automated reading	0.4	1.2	1.6	-1.1	-0.9	-1.3
Alcohol intake frequency.	1.1	2.5	6.5	-1.0	-2.5	0.3
Comparative height size at age 10	4.3	23.5	46.6	-4.8	-6.8	0.9
Number of full sisters	2.0	2.5	4.5	-1.5	-2.1	-0.7
Suffer from ‘nerves’	1.0	1.6	2.6	1.0	1.6	1.1
Overall health rating	2.6	5.7	8.8	-3.0	-2.8	-0.8
Chest pain or discomfort	0.8	1.1	1.3	-1.1	-1.0	-1.1
Had major operations	2.3	2.7	4.0	-1.6	-1.2	-2.0
Age at last live birth	0.5	0.8	2.0	0.1	1.4	-0.7
Family relationship satisfaction	1.7	2.1	3.8	1.6	2.0	-0.1
Leg pain on walking	1.2	1.5	2.7	-1.2	-1.6	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.1	2.5	-1.5	-1.6	-1.3
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.8	0.6	-0.1	0.9
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.3	0.5	1.1	0.5
Medication: Aspirin	1.5	2.0	3.5	-1.9	-1.4	-0.7
Supplements: Vitamin C	0.8	0.9	1.4	0.8	0.9	1.2
Knee pain experienced in last month	0.2	0.4	0.9	-0.9	-0.2	-0.4
Hypertension (Self-reported)	0.7	2.1	4.8	1.2	0.3	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.1	1.0	0.6	1.8
Illnesses of father: Heart disease	0.5	0.7	0.9	0.9	1.0	0.5
Illnesses of siblings: Diabetes	0.3	0.4	0.7	-0.6	-0.8	-0.2
Smoking status: Previous	0.5	0.7	1.6	-0.6	-1.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.9	6.4	-2.5	-2.5	-1.5
Whole body fat-free mass	9.1	52.2	106.1	-7.1	-10.3	-0.8
Leg fat-free mass (right)	8.8	47.3	94.3	-6.8	-9.7	-1.1
Arm fat percentage (left)	0.7	3.0	5.8	-1.8	-2.4	-0.0
Average weekly red wine intake	0.8	1.1	1.7	1.2	1.3	0.6
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	-0.3	-0.8	0.9
Mood swings	0.7	1.2	2.7	0.7	1.7	-0.7
Loneliness, isolation	0.1	0.1	0.2	0.4	0.5	-0.2
Long-standing illness, disability or infirmity	1.4	2.2	3.2	-1.8	-1.5	-1.1
Ever had bowel cancer screening	0.7	0.8	1.6	-0.6	-1.2	0.6
Diabetes diagnosed by doctor	4.6	7.5	10.8	-3.3	-2.6	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.6	-0.6	-0.1
Friendships satisfaction	0.5	0.6	1.6	-0.5	-0.2	-1.3
Qualifications: nursing, teaching	0.6	0.9	1.2	1.0	0.7	1.1
Commuting to job workplace: Walk	1.1	1.2	2.4	0.6	0.9	-1.6
Eye problems/disorders: Cataract	1.8	2.1	2.8	-1.7	-1.4	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.8	-0.6	-0.9	0.8
Medication for cholesterol	0.5	0.8	1.5	0.8	0.5	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	3.3	-1.8	-1.5	-1.1
Back pain experienced in last month	4.7	6.8	11.1	-3.3	-3.1	0.2
Mineral and other dietary supplements	0.5	0.7	1.4	-0.2	-1.2	0.8
Breast cancer (self-reported)	1.4	1.7	4.8	0.5	-0.4	2.2
Asthma (self-reported)	1.8	3.5	6.4	-1.9	-0.8	-2.5
Osteoporosis (self-reported)	0.0	0.0	0.1	0.3	0.0	-0.0
Osteoarthritis (self-reported)	1.5	1.9	3.9	-2.0	-1.1	-0.8
Medication: Aspirin	1.0	1.2	2.5	-1.6	-1.1	-0.3
Medication: Gliclazide	0.3	0.3	0.7	0.5	0.2	0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	0.5	-0.7	-0.7	-0.6
Smoking status: Current	2.5	3.9	5.8	-2.4	-2.0	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	4.9	2.2	1.0	2.0
Whole body water mass	9.4	53.4	108.2	-7.2	-10.4	-0.8
Leg predicted mass (right)	8.8	46.7	92.9	-6.8	-9.6	-1.2
Arm fat mass (left)	3.5	14.3	28.2	-3.8	-5.3	-0.2
Number of self-reported non-cancer illnesses	1.1	1.9	2.7	-1.0	-1.4	-1.6
Average weekly champagne plus white wine intake	0.6	0.9	2.4	0.3	0.3	1.5
Miserableness	2.9	5.1	10.4	1.8	3.2	-1.3
Guilty feelings	0.9	1.4	2.5	-1.6	-0.9	-0.9
Wears glasses or contact lenses	2.1	2.4	3.6	-1.1	-1.6	-1.9
Ever taken oral contraceptive pill	0.5	0.6	1.4	-0.6	0.2	-1.2
Hearing aid user	0.6	0.6	1.8	0.2	-0.0	1.4
Mother’s age at death	0.1	0.1	0.1	0.3	0.2	-0.3
Financial situation satisfaction	0.5	0.6	1.8	0.1	0.0	-1.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	-0.4	-0.0	0.6
Commuting to job workplace: Public transport	2.0	2.4	3.8	-1.9	-1.2	-1.5
Eye problems/disorders: Glaucoma	1.6	1.9	3.5	-0.5	-1.9	1.3
Medication: Blood pressure	0.6	1.2	2.4	1.0	0.5	1.5
Pain type(s) experienced in last month: Hip pain	1.5	1.9	3.3	-1.5	-1.8	-0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	0.5	0.9	0.0
High cholesterol (Self-reported)	0.4	0.6	1.4	-0.7	-0.1	-1.2
Medication: Bendroflumethiazide	0.3	0.5	0.7	0.8	0.3	0.9
Medication: Paracetamol	0.9	1.3	2.0	-0.8	-1.4	1.1
Medication: Lisinopril	0.5	0.7	1.3	-0.8	-1.1	-0.4
Medication: Atorvastatin	2.4	2.9	4.8	0.7	1.9	2.2
Illnesses of father: High blood pressure	0.4	0.5	0.6	-0.5	-0.8	0.7
Alcohol drinker status: Never	2.1	2.5	3.8	-1.0	-2.0	1.6
Ever smoked	1.1	1.9	2.9	-1.6	-1.7	-0.7
Basal metabolic rate	8.7	48.2	97.0	-6.9	-9.8	-0.7
Leg fat percentage (left)	0.1	0.3	0.4	-0.4	-0.7	0.5
Arm fat-free mass (left)	8.2	41.5	84.8	-6.3	-9.2	-0.5
Number of operations (self-reported)	4.1	6.1	9.3	-2.6	-3.1	-1.6
Average weekly beer plus cider intake	0.1	0.2	0.2	0.5	0.3	-0.5
Irritability	0.6	1.1	1.6	-1.2	-0.2	-1.3
Risk taking	0.3	0.5	0.6	-0.5	-0.8	0.7
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.5	-0.2	-0.7	-0.5
Fractured/broken bones in last 5 years	1.8	2.4	4.6	1.6	2.1	-0.2
Age started oral contraceptive pill	0.6	0.7	1.3	0.7	0.5	1.1
Diastolic blood pressure, automated reading	4.0	12.3	32.1	2.1	0.7	5.7
Ever depressed for a whole week	0.6	0.8	1.5	-1.2	-0.2	-0.8
Unable to work because of sickness or disability	0.2	0.2	0.6	-0.3	0.2	-0.8
Commuting to job workplace: Cycle	1.3	1.6	2.4	1.5	1.5	0.4
Myopia	0.1	0.2	0.4	-0.3	-0.6	0.2
Vascular/heart problems diagnosed by doctor	0.6	1.6	4.3	-0.7	0.0	-2.1
Cholesterol lowering medication	0.2	0.3	0.6	-0.2	0.8	-0.6
Medication: Omeprazole (e.g. Zanprol)	2.0	2.5	4.0	-1.8	-2.0	0.3
Pain experienced in last month	0.4	0.7	1.5	1.2	0.7	-0.3
Supplements: Calcium	0.0	0.0	0.1	-0.1	0.2	0.3
Basal cell carcinoma (self-reported)	0.6	0.7	1.4	-0.8	-1.2	-0.1
Heart attack/myocardial infarction (self-reported)	3.7	4.8	8.5	-2.9	-2.3	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	2.6	-1.4	-1.4	-1.6
Heart disease (siblings)	0.6	0.8	1.1	-1.0	-0.8	0.8
Alcohol drinker status: Previous	0.4	0.5	0.6	0.7	0.7	-0.7
Pack years of smoking	0.7	1.0	1.5	-0.5	-1.2	1.1
Impedance of whole body	6.6	33.4	73.7	5.1	8.6	0.5
Leg fat mass (left)	2.4	9.2	17.9	-3.1	-4.2	-0.1
Arm predicted mass (left)	8.5	43.1	88.2	-6.4	-9.4	-0.4