TWAS hub - KCNH2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.343	0.114	5.8e-03	0.089	NA	0.101	NA	0.122	2.8e-03	NA	1.5e-03	NA	5.0e-04
2	GTEx	Brain Cerebellum	0.350	0.080	4.3e-05	0.205	NA	0.284	NA	0.279	1.1e-06	NA	4.8e-09	NA	6.8e-09
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.126	0.054	7.1e-04	0.030	0.072	0.067	NA	0.054	7.3e-03	6.4e-05	1.1e-04	NA	4.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Eye problems/disorders: Diabetes related eye disease	11.1	12.2	15.1	-3.9	-2.6	-3.8
Whole body water mass	9.4	53.4	108.2	-7.2	-10.4	-0.8
Whole body fat-free mass	9.1	52.2	106.1	-7.1	-10.3	-0.8
Trunk fat-free mass	8.8	50.6	104.0	-6.9	-10.2	-0.5
Trunk predicted mass	8.8	50.1	104.0	-6.8	-10.2	-0.4
Leg fat-free mass (right)	8.8	47.3	94.3	-6.8	-9.7	-1.1
Leg predicted mass (right)	8.8	46.7	92.9	-6.8	-9.6	-1.2
Basal metabolic rate	8.7	48.2	97.0	-6.9	-9.8	-0.7
Leg fat-free mass (left)	8.6	45.6	90.6	-6.8	-9.5	-0.8
Leg predicted mass (left)	8.6	45.5	90.4	-6.7	-9.5	-0.9
Arm fat-free mass (right)	8.5	43.5	86.7	-6.5	-9.3	-1.0
Arm predicted mass (left)	8.5	43.1	88.2	-6.4	-9.4	-0.4
Arm predicted mass (right)	8.4	43.0	85.6	-6.5	-9.2	-0.9
Arm fat-free mass (left)	8.2	41.5	84.8	-6.3	-9.2	-0.5
Impedance of leg (left)	7.4	35.7	76.8	5.4	8.8	1.1
Impedance of leg (right)	7.1	34.3	73.7	5.2	8.6	1.3
Impedance of whole body	6.6	33.4	73.7	5.1	8.6	0.5
Weight	6.2	30.4	60.2	-5.6	-7.8	-0.2
Eye problems/disorders: None of the above	5.1	5.9	7.4	2.7	2.4	2.1
Diabetes (mother)	5.0	6.4	8.1	-2.5	-2.3	-2.8
Impedance of arm (right)	4.8	22.3	47.6	4.3	6.9	0.8
Impedance of arm (left)	4.7	22.0	49.1	4.1	7.0	0.1
Back pain experienced in last month	4.7	6.8	11.1	-3.3	-3.1	0.2
Diabetes diagnosed by doctor	4.6	7.5	10.8	-3.3	-2.6	-2.2
Comparative height size at age 10	4.3	23.5	46.6	-4.8	-6.8	0.9
Hip circumference	4.2	18.2	32.6	-4.5	-5.7	-1.3
Number of operations (self-reported)	4.1	6.1	9.3	-2.6	-3.1	-1.6
Diastolic blood pressure, automated reading	4.0	12.3	32.1	2.1	0.7	5.7
Heart attack/myocardial infarction (self-reported)	3.7	4.8	8.5	-2.9	-2.3	-0.7
Body Mass Index (BMI) (2010)	3.6	4.9	8.2	-2.5	-2.9	-0.3
Heart attack	3.6	4.6	7.8	-2.8	-2.3	-0.7
HDL Cholesterol	3.5	5.8	8.4	2.9	2.9	-0.8
Diabetes (self-reported)	3.5	5.4	7.1	-2.7	-2.3	-1.9
Arm fat mass (left)	3.5	14.3	28.2	-3.8	-5.3	-0.2
Sitting height	3.3	23.8	41.0	-5.5	-6.4	-0.8
BMI	3.2	18.5	35.8	-4.4	-6.0	0.5
Number of incorrect matches in round	3.2	5.4	5.9	2.4	2.4	-2.1
Arm fat mass (right)	3.2	13.0	26.2	-3.6	-5.1	-0.0
Waist circumference	3.1	11.3	22.9	-3.3	-4.8	-0.3
Current tobacco smoking	3.0	4.9	6.6	-2.6	-2.2	-1.8
Stomach or abdominal pain in last month	3.0	3.7	6.6	-2.6	-2.1	-0.3
Allergy	3.0	7.0	8.4	2.9	2.6	2.4
Allergy or Eczema	2.9	7.6	11.4	-3.4	-2.7	-2.0
Miserableness	2.9	5.1	10.4	1.8	3.2	-1.3
Smoking Status	2.8	6.7	10.6	-3.1	-3.3	-0.1
Medication for hormone replacement therapy	2.8	3.1	4.8	-1.8	-2.2	-1.2
Supplements: Glucosamine	2.8	3.6	9.1	-1.3	0.2	-3.0
Body mass index (BMI)	2.8	11.9	24.7	-3.3	-5.0	0.2
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.1	5.0	-2.0	-2.2	0.6
Standing height	2.6	25.7	47.5	-5.4	-6.9	-0.5
Blood clot in the leg (DVT)	2.6	3.4	3.5	-1.8	-1.9	-1.9
Overall health rating	2.6	5.7	8.8	-3.0	-2.8	-0.8
Depressed Affect (Nagel 2018)	2.5	5.2	9.2	2.5	3.0	0.6
Type 2 Diabetes (T2D) (2018)	2.5	4.7	7.2	-2.7	-2.2	-1.4
Whole body fat mass	2.5	10.4	20.2	-3.3	-4.5	-0.1
Smoking status: Current	2.5	3.9	5.8	-2.4	-2.0	-1.5
Height	2.4	45.5	87.6	-6.8	-9.4	-1.5
Chronotype (morning person)	2.4	5.5	11.6	-1.8	-3.4	1.2
Medication: Seretide 50 evohaler	2.4	2.7	4.4	-2.1	-1.0	-1.7
Leg fat mass (right)	2.4	9.3	17.9	-3.2	-4.2	0.1
Medication: Atorvastatin	2.4	2.9	4.8	0.7	1.9	2.2
Leg fat mass (left)	2.4	9.2	17.9	-3.1	-4.2	-0.1
Had major operations	2.3	2.7	4.0	-1.6	-1.2	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.9	6.4	-2.5	-2.5	-1.5
Health satisfaction	2.2	2.9	5.4	-2.3	-1.1	-1.4
Systolic blood pressure, automated reading	2.1	6.0	16.3	0.9	-1.0	4.0
Trunk fat mass	2.1	8.9	16.7	-3.1	-4.1	-0.3
Medication: Allopurinol	2.1	2.8	8.4	-0.1	0.1	-2.9
Wears glasses or contact lenses	2.1	2.4	3.6	-1.1	-1.6	-1.9
Alcohol drinker status: Never	2.1	2.5	3.8	-1.0	-2.0	1.6
Medication: Metformin	2.0	2.8	3.9	-1.8	-2.0	-1.1
Number of full sisters	2.0	2.5	4.5	-1.5	-2.1	-0.7
Commuting to job workplace: Public transport	2.0	2.4	3.8	-1.9	-1.2	-1.5
Medication: Omeprazole (e.g. Zanprol)	2.0	2.5	4.0	-1.8	-2.0	0.3
Asthma	1.9	3.8	7.5	-1.8	-0.7	-2.7
Birth weight of first child	1.9	3.4	5.9	-0.7	-2.4	2.0
Medication for pain relief, constipation, heartburn	1.9	3.3	5.7	2.0	2.4	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	3.3	-1.8	-1.5	-1.1
Number of treatments/medications taken	1.8	3.2	5.4	-2.3	-2.0	0.2
Medication: Lansoprazole	1.8	2.0	6.0	-0.1	0.1	2.5
Medication: Omeprazole	1.8	2.1	3.4	-1.7	-1.9	0.2
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.1	2.5	-1.5	-1.6	-1.3
Eye problems/disorders: Cataract	1.8	2.1	2.8	-1.7	-1.4	-1.2
Asthma (self-reported)	1.8	3.5	6.4	-1.9	-0.8	-2.5
Fractured/broken bones in last 5 years	1.8	2.4	4.6	1.6	2.1	-0.2
Systolic Blood Pressure	1.7	8.5	25.0	0.2	-0.6	5.0
Respiratory disease	1.7	3.8	6.0	-2.5	-1.6	-1.6
Hayfever, allergic rhinitis or eczema	1.7	3.8	5.6	-2.4	-1.9	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	3.6	1.6	1.9	-0.5
Family relationship satisfaction	1.7	2.1	3.8	1.6	2.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	2.6	-1.4	-1.4	-1.6
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	3.4	-0.8	-1.2	-1.8
Pulse wave reflection index	1.6	1.9	3.5	-1.5	-1.9	0.2
Eye problems/disorders: Glaucoma	1.6	1.9	3.5	-0.5	-1.9	1.3
Angina	1.5	2.0	3.1	-1.5	-0.7	-1.8
Peak expiratory flow (PEF)	1.5	3.6	9.7	-0.5	-0.8	3.1
Medication: Ventolin 100micrograms inhaler	1.5	1.9	2.2	-1.3	-1.5	-1.3
Comparative body size at age 10	1.5	4.1	6.4	-1.9	-2.5	1.5
Medication: Aspirin	1.5	2.0	3.5	-1.9	-1.4	-0.7
Osteoarthritis (self-reported)	1.5	1.9	3.9	-2.0	-1.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	4.9	2.2	1.0	2.0
Pain type(s) experienced in last month: Hip pain	1.5	1.9	3.3	-1.5	-1.8	-0.3
Average weekly spirits intake	1.4	1.7	1.8	-1.3	-1.4	-1.2
Mouth/teeth dental problems: Dentures	1.4	2.4	3.7	-1.5	-1.9	-1.1
Long-standing illness, disability or infirmity	1.4	2.2	3.2	-1.8	-1.5	-1.1
Breast cancer (self-reported)	1.4	1.7	4.8	0.5	-0.4	2.2
Blood Platelet Count	1.3	14.6	18.7	-4.3	-4.3	-2.5
Ever used hormone-replacement therapy (HRT)	1.3	1.6	2.3	-1.5	-1.5	-0.4
Hair/balding pattern: Pattern 4	1.3	3.1	3.6	-1.9	-1.6	-1.8
Number of children fathered	1.3	1.4	1.9	-1.4	-1.4	-0.7
Angina (self-reported)	1.3	1.7	2.9	-1.4	-0.5	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.1	1.0	0.6	1.8
Commuting to job workplace: Cycle	1.3	1.6	2.4	1.5	1.5	0.4
Neuroticism (2016)	1.2	1.7	4.6	0.8	2.1	-0.2
Severe depression (siblings)	1.2	1.4	4.0	-0.0	-0.3	2.0
Relative age voice broke	1.2	1.9	3.3	-1.8	-0.6	-1.4
Had menopause	1.2	1.5	2.6	1.2	0.7	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	3.3	-1.8	-1.0	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.2	0.9	1.5	-1.1
Medication: Ibuprofen	1.2	1.4	2.3	-0.8	-1.5	1.2
Leg pain on walking	1.2	1.5	2.7	-1.2	-1.6	0.7
Primary Biliary Cirrhosis	1.1	1.6	2.0	-1.1	-1.3	-1.4
Lung FVC	1.1	5.5	9.2	2.4	1.2	3.0
Hand grip strength (right)	1.1	3.0	3.9	-1.9	-2.0	1.3
Age when periods started (menarche)	1.1	2.6	5.1	1.5	2.2	-0.7
High blood pressure	1.1	3.0	7.3	1.2	0.3	2.7
Past tobacco smoking	1.1	2.0	3.6	1.5	1.9	0.5
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	7.1	-0.6	-1.9	2.7
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.3	2.3	-1.1	-1.5	0.7
Exposure to tobacco smoke at home	1.1	1.2	2.7	-0.8	-0.4	-1.7
Alcohol intake frequency.	1.1	2.5	6.5	-1.0	-2.5	0.3
Commuting to job workplace: Walk	1.1	1.2	2.4	0.6	0.9	-1.6
Number of self-reported non-cancer illnesses	1.1	1.9	2.7	-1.0	-1.4	-1.6
Ever smoked	1.1	1.9	2.9	-1.6	-1.7	-0.7
Crohns Disease (2017)	1.0	2.1	4.1	-2.0	-0.8	-1.3
Triglycerides	1.0	1.7	2.8	-1.7	-1.5	0.3
Chronic bronchitis/emphysema (father)	1.0	1.2	2.3	-0.8	-0.8	-1.5
High blood pressure (mother)	1.0	1.4	1.6	-1.0	-1.3	-1.3
Mouth/teeth dental problems	1.0	1.6	2.4	1.6	1.5	0.1
Qualifications: A levels/AS levels or equivalent	1.0	2.3	6.4	0.6	0.3	2.5
Suffer from ‘nerves’	1.0	1.6	2.6	1.0	1.6	1.1
Medication: Aspirin	1.0	1.2	2.5	-1.6	-1.1	-0.3
Neuroticism (Nagel 2018)	0.9	2.1	4.6	1.3	2.1	-0.3
Coronary Artery Disease (CAD)	0.9	1.1	1.8	-1.4	-1.2	0.0
Hand grip strength (left)	0.9	2.5	5.1	-0.7	-1.3	2.2
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.1	-1.1	-1.5	0.2
Pack years adult smoking proportion	0.9	1.3	2.0	-0.9	-1.4	1.1
Hair/balding pattern: Pattern 2	0.9	1.1	1.5	1.2	1.2	0.6
Forced vital capacity (FVC)	0.9	3.4	5.1	-0.7	-2.3	2.1
Illnesses of mother	0.9	1.1	1.3	1.0	1.1	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	6.6	0.1	-1.4	2.6
Guilty feelings	0.9	1.4	2.5	-1.6	-0.9	-0.9
Medication: Paracetamol	0.9	1.3	2.0	-0.8	-1.4	1.1
Irritable Bowel Disease (IBD)	0.8	1.8	3.2	-1.4	-0.6	-1.8
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.3	1.0	0.5	1.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.1	-1.4	-1.0	-0.1
Pulse wave Arterial Stiffness index	0.8	1.0	1.3	-0.9	-1.1	0.9
Breastfed as a baby	0.8	1.0	1.5	-0.8	-0.9	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.0	0.2	0.7	-1.7
Gout (self-reported)	0.8	1.2	3.4	0.1	-0.1	-1.9
Forced vital capacity (FVC), Best measure	0.8	2.9	7.0	0.6	-1.1	2.6
Neck or shoulder pain in last month	0.8	1.2	2.3	-1.5	-0.4	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.3	-1.1	-0.8	1.1
Chest pain or discomfort	0.8	1.1	1.3	-1.1	-1.0	-1.1
Supplements: Vitamin C	0.8	0.9	1.4	0.8	0.9	1.2
Average weekly red wine intake	0.8	1.1	1.7	1.2	1.3	0.6
Depression (Nagel 2018)	0.7	1.0	1.6	1.2	1.3	-0.1
Breast Cancer	0.7	1.6	3.9	-0.6	-0.7	2.0
Ovarian Cancer	0.7	0.9	1.1	-1.1	-0.8	0.9
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.5	-0.9	-1.2	0.2
Hearing difficulty/problems: Yes	0.7	1.1	2.0	-1.4	-1.1	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.3	0.7	1.1	-1.2
Taking other prescription medications	0.7	1.1	2.3	-0.9	-1.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	2.8	-1.5	-1.7	0.1
Hearing difficulty/problems with background noise	0.7	1.2	1.9	-1.4	-1.3	0.0
Arm fat percentage (right)	0.7	2.7	5.8	-1.5	-2.4	0.3
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.3	-1.1	-1.0	-0.4
Age at first live birth	0.7	1.2	3.0	-0.1	1.7	-0.8
Emphysema/chronic bronchitis	0.7	0.8	1.7	1.3	0.7	0.0
Hypertension (Self-reported)	0.7	2.1	4.8	1.2	0.3	2.2
Arm fat percentage (left)	0.7	3.0	5.8	-1.8	-2.4	-0.0
Mood swings	0.7	1.2	2.7	0.7	1.7	-0.7
Ever had bowel cancer screening	0.7	0.8	1.6	-0.6	-1.2	0.6
Pack years of smoking	0.7	1.0	1.5	-0.5	-1.2	1.1
Alzheimer’s Disease (in mother)	0.6	0.7	1.5	-0.4	-0.6	1.2
Cardiovascular Disease	0.6	2.1	6.1	0.3	0.2	2.5
Relative age of first facial hair	0.6	1.2	2.4	-0.9	-0.6	-1.5
Townsend deprivation index at recruitment	0.6	0.9	1.4	-1.0	-0.4	-1.2
Average weekly fortified wine intake	0.6	0.7	1.1	0.6	0.8	-1.1
Nervous feelings	0.6	1.1	2.1	0.6	1.4	-0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.2	0.3	1.5	-0.0
Medication: Ramipril	0.6	0.8	1.7	-0.8	0.1	-1.3
Illnesses of siblings	0.6	0.8	1.2	1.0	0.5	-1.1
Time employed in main current job	0.6	0.7	1.2	-1.1	-1.0	0.2
Alcohol intake versus 10 years previously	0.6	0.9	2.5	0.1	0.2	-1.6
Noisy workplace	0.6	0.7	0.8	0.8	0.9	0.8
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.3	0.7	1.2	-0.6
Loud music exposure frequency	0.6	0.6	0.8	0.8	0.9	0.7
Medication: Paracetamol	0.6	1.1	2.3	-0.7	-1.5	0.6
Glaucoma (self-reported)	0.6	0.8	2.2	-0.0	-1.5	0.3
Qualifications: nursing, teaching	0.6	0.9	1.2	1.0	0.7	1.1
Average weekly champagne plus white wine intake	0.6	0.9	2.4	0.3	0.3	1.5
Hearing aid user	0.6	0.6	1.8	0.2	-0.0	1.4
Medication: Blood pressure	0.6	1.2	2.4	1.0	0.5	1.5
Irritability	0.6	1.1	1.6	-1.2	-0.2	-1.3
Age started oral contraceptive pill	0.6	0.7	1.3	0.7	0.5	1.1
Ever depressed for a whole week	0.6	0.8	1.5	-1.2	-0.2	-0.8
Vascular/heart problems diagnosed by doctor	0.6	1.6	4.3	-0.7	0.0	-2.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.4	-0.8	-1.2	-0.1
Heart disease (siblings)	0.6	0.8	1.1	-1.0	-0.8	0.8
Schizophrenia vs Biploar Disorder	0.5	0.7	1.8	0.2	0.5	-1.3
Alzheimer’s Disease (in father)	0.5	0.5	0.9	0.3	0.7	-0.9
Schizophrenia (2014)	0.5	1.0	1.5	-0.7	-1.0	-1.2
Blood Eosinophil Count	0.5	3.6	7.2	-1.9	0.4	-2.7
Neuroticism	0.5	1.3	2.6	0.9	1.6	-0.6
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.2	0.5	0.7	-1.1
Medication: Co-codamol	0.5	0.5	0.9	-0.7	-0.6	-0.9
Maternal smoking around birth	0.5	0.7	1.0	1.0	0.9	0.6
Serious illness, injury or assault to yourself	0.5	0.6	1.3	-0.5	-1.2	-0.6
Multivitamins +/- minerals	0.5	0.6	1.4	0.5	1.2	-0.3
Financial difficulties in last 2 years	0.5	0.7	1.6	0.0	-0.6	-1.3
Medication: Simvastatin	0.5	0.7	2.0	-0.4	0.1	-1.4
Length of working week for main job	0.5	0.6	0.7	-0.9	-0.8	0.7
High blood pressure (siblings)	0.5	0.7	1.8	-0.3	0.5	1.3
Age at last live birth	0.5	0.8	2.0	0.1	1.4	-0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.3	0.5	1.1	0.5
Illnesses of father: Heart disease	0.5	0.7	0.9	0.9	1.0	0.5
Smoking status: Previous	0.5	0.7	1.6	-0.6	-1.3	0.1
Friendships satisfaction	0.5	0.6	1.6	-0.5	-0.2	-1.3
Medication for cholesterol	0.5	0.8	1.5	0.8	0.5	1.2
Mineral and other dietary supplements	0.5	0.7	1.4	-0.2	-1.2	0.8
Ever taken oral contraceptive pill	0.5	0.6	1.4	-0.6	0.2	-1.2
Financial situation satisfaction	0.5	0.6	1.8	0.1	0.0	-1.4
Medication: Lisinopril	0.5	0.7	1.3	-0.8	-1.1	-0.4
Worry (Nagel 2018)	0.4	0.8	1.7	0.7	1.3	-0.5
Ulcerative Colitis (UC)	0.4	0.8	2.0	-0.3	-0.6	-1.4
Reaction Time	0.4	0.9	2.5	0.2	1.6	-0.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.3	0.7	0.3	1.5
Prostate Cancer	0.4	0.6	1.1	-1.1	-0.9	-0.0
Waist Hip Ratio (WHR)	0.4	1.9	2.5	1.6	1.5	0.9
Sensitivity / hurt feelings	0.4	0.7	1.8	-0.6	0.1	-1.3
Alcohol usually taken with meals	0.4	0.6	1.1	0.7	1.1	-0.4
Fluid intelligence score	0.4	0.8	1.9	0.7	0.1	1.4
Tense / ‘highly strung’	0.4	0.6	1.6	-0.4	0.1	-1.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.4	-0.3	0.3	-1.2
Wheeze or whistling in the chest in last year	0.4	0.7	1.3	-0.6	-0.6	1.1
Mean time to correctly identify matches	0.4	0.7	1.6	0.4	1.3	-0.7
Pulse rate, automated reading	0.4	1.2	1.6	-1.1	-0.9	-1.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	-0.3	-0.8	0.9
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.8	-0.6	-0.9	0.8
High cholesterol (Self-reported)	0.4	0.6	1.4	-0.7	-0.1	-1.2
Illnesses of father: High blood pressure	0.4	0.5	0.6	-0.5	-0.8	0.7
Pain experienced in last month	0.4	0.7	1.5	1.2	0.7	-0.3
Alcohol drinker status: Previous	0.4	0.5	0.6	0.7	0.7	-0.7
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.8	1.0	0.6	1.4
Age at First Birth	0.3	0.4	0.7	-0.8	0.0	-0.8
Bipolar Disorder (2011)	0.3	0.3	0.5	0.7	-0.5	0.0
Crohns Disease (2012)	0.3	0.5	0.9	-0.4	0.6	-1.0
Mean Putamen Volume	0.3	0.4	0.6	0.7	0.7	0.2
Lupus	0.3	0.5	1.3	0.0	-0.4	1.1
Blood Red Count	0.3	2.5	7.3	-0.1	-0.5	2.7
Tanning	0.3	4.2	9.9	-1.4	-0.8	-3.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	-0.3	0.5	-1.1
Neuroticism score	0.3	0.6	1.1	-0.3	0.8	-1.1
Falls in the last year	0.3	0.5	1.1	-1.0	-0.2	-0.6
Number of live births	0.3	0.4	0.6	-0.4	-0.8	0.6
Medication: Cholesterol lowering	0.3	0.5	1.3	-0.4	0.1	-1.1
Depression (self-reported)	0.3	0.4	0.4	0.6	0.6	-0.6
Number of full brothers	0.3	0.4	0.6	-0.8	-0.3	0.7
Worry too long after embarrassment	0.3	0.6	1.3	-0.6	-0.2	-1.2
Pulse wave peak to peak time	0.3	0.3	0.6	0.3	0.4	-0.8
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.8	-0.0	0.3	0.9
Heart disease (mother)	0.3	0.3	0.5	-0.5	-0.7	0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.8	0.6	-0.1	0.9
Illnesses of siblings: Diabetes	0.3	0.4	0.7	-0.6	-0.8	-0.2
Medication: Gliclazide	0.3	0.3	0.7	0.5	0.2	0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	0.5	-0.7	-0.7	-0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	0.5	0.9	0.0
Medication: Bendroflumethiazide	0.3	0.5	0.7	0.8	0.3	0.9
Risk taking	0.3	0.5	0.6	-0.5	-0.8	0.7
Major Depression (MDD)	0.2	0.3	0.6	-0.2	0.4	0.8
Fasting Glucose	0.2	0.2	0.4	-0.6	-0.4	0.2
HbA1C	0.2	0.3	0.5	-0.2	-0.4	0.7
Hypothyroidism (self reported)	0.2	0.5	0.9	-1.0	-0.8	-0.3
Ever had hysterectomy (womb removed)	0.2	0.3	0.7	0.3	0.3	-0.8
Diabetes (father)	0.2	0.3	0.7	0.2	-0.3	0.8
Trunk fat percentage	0.2	1.0	1.5	-1.2	-1.2	-0.2
Fed-up feelings	0.2	0.4	0.9	0.3	1.0	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.9	-0.3	-0.6	0.9
Qualifications: None of the above	0.2	0.3	0.7	0.4	0.4	-0.8
Father’s age at death	0.2	0.3	0.5	-0.4	-0.7	-0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.2	-0.4	0.8
Happiness	0.2	0.2	0.4	-0.6	-0.4	-0.4
Prospective memory result	0.2	0.3	0.4	-0.0	-0.6	-0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	-0.4	-0.3	0.9
Birth weight	0.2	0.5	0.9	-0.7	-0.9	-0.4
Body fat percentage	0.2	0.7	1.2	-0.9	-1.1	0.1
Knee pain experienced in last month	0.2	0.4	0.9	-0.9	-0.2	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.6	-0.6	-0.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	-0.4	-0.0	0.6
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.5	-0.2	-0.7	-0.5
Unable to work because of sickness or disability	0.2	0.2	0.6	-0.3	0.2	-0.8
Cholesterol lowering medication	0.2	0.3	0.6	-0.2	0.8	-0.6
Bipolar Disorder (2018)	0.1	0.2	0.2	-0.5	-0.5	0.2
Schizophrenia (2018)	0.1	0.2	0.4	0.6	0.1	-0.5
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	-0.1	-0.1	0.6
LDL Cholesterol	0.1	0.2	0.3	-0.6	-0.5	-0.1
Rheumatoid Arthritis	0.1	0.1	0.2	0.3	0.4	-0.2
Ulcerative Colitis	0.1	0.1	0.2	0.2	-0.3	-0.4
Blood White Count	0.1	1.0	1.4	-1.2	-1.0	0.8
Heel T-Score	0.1	0.7	1.3	-1.2	-0.7	-0.4
Lung FEV1/FVC ratio	0.1	0.5	1.1	-0.5	-0.6	1.0
Vitamin and mineral supplements	0.1	0.1	0.2	0.2	-0.5	0.2
Qualifications: CSEs or equivalent	0.1	0.2	0.3	-0.4	0.5	-0.3
Medication: Atenolol	0.1	0.1	0.2	-0.5	-0.2	-0.3
Medication: Levothyroxine sodium	0.1	0.1	0.3	0.5	0.3	0.3
Had other major operations	0.1	0.2	0.4	0.3	-0.6	0.1
Pain all over the body in last month	0.1	0.1	0.3	-0.2	-0.6	-0.3
Worrier / anxious feelings	0.1	0.3	0.7	-0.1	-0.3	0.9
Pulse rate	0.1	0.2	0.6	-0.2	-0.0	-0.8
Lung cancer (father)	0.1	0.1	0.2	0.1	-0.4	-0.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	-0.1	-0.6	0.4
Medication: Amlodipine	0.1	0.1	0.3	0.6	-0.1	-0.1
Leg fat percentage (right)	0.1	0.4	0.5	-0.5	-0.7	0.7
Exposure to tobacco smoke outside home	0.1	0.2	0.5	-0.7	-0.3	0.1
Shortness of breath walking on level ground	0.1	0.2	0.3	0.4	0.1	-0.6
Qualifications: College or University degree	0.1	0.2	0.3	0.0	0.6	0.6
Migraine (self-reported)	0.1	0.1	0.3	-0.5	0.1	-0.0
Loneliness, isolation	0.1	0.1	0.2	0.4	0.5	-0.2
Mother’s age at death	0.1	0.1	0.1	0.3	0.2	-0.3
Leg fat percentage (left)	0.1	0.3	0.4	-0.4	-0.7	0.5
Average weekly beer plus cider intake	0.1	0.2	0.2	0.5	0.3	-0.5
Myopia	0.1	0.2	0.4	-0.3	-0.6	0.2
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	0.2	-0.2	-0.3
Hair Pigment	0.0	0.2	0.2	-0.5	-0.0	-0.5
Supplements: Zinc	0.0	0.0	0.1	-0.0	-0.1	-0.3
Diverticular disease/diverticulitis (self-reported)	0.0	0.1	0.1	0.0	-0.2	-0.3
Headache pain in last month	0.0	0.1	0.1	0.3	0.2	0.3
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	-0.3	-0.1	0.1
Medication: Blood pressure	0.0	0.1	0.2	-0.1	0.4	0.0
Osteoporosis (self-reported)	0.0	0.0	0.1	0.3	0.0	-0.0
Supplements: Calcium	0.0	0.0	0.1	-0.1	0.2	0.3

Hub : Genes

KCNH2

Models

Trait associations