Best TWAS P=6.77e-19 · Best GWAS P=5.72e-18 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | GTF3C2 | 0.06 | 0.09 | lasso | 8 | 0.08 | 7.2e-10 | 4.6 | -5.9 | 4.2e-09 | 0.72 | 0.33 | 0.67 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | IFT172 | 0.06 | 0.09 | enet | 16 | 0.09 | 3.9e-11 | 3.9 | 5.3 | 1.4e-07 | -0.75 | 0.45 | 0.55 | FALSE |
| 3 | GTEx | Artery Tibial | PPM1G | 0.06 | 0.02 | lasso | 4 | 0.03 | 2.3e-03 | 4.6 | -5.3 | 1.0e-07 | 0.66 | 0.28 | 0.13 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | NRBP1 | 0.11 | 0.01 | enet | 23 | 0.02 | 7.7e-02 | 2.5 | -5.4 | 5.6e-08 | 0.53 | 0.12 | 0.22 | FALSE |
| 5 | GTEx | Esophagus Mucosa | AC074117.10 | 0.12 | 0.14 | lasso | 8 | 0.14 | 2.1e-09 | 4.8 | -5.4 | 6.0e-08 | 0.74 | 0.93 | 0.07 | FALSE |
| 6 | GTEx | Esophagus Muscularis | NRBP1 | 0.07 | 0.04 | lasso | 6 | 0.04 | 1.3e-03 | 4.8 | -6.8 | 1.1e-11 | 0.82 | 0.02 | 0.96 | FALSE |
| 7 | GTEx | Ovary | AC074117.10 | 0.16 | 0.04 | enet | 9 | 0.05 | 2.0e-02 | 3.7 | -5.9 | 3.7e-09 | 0.77 | 0.04 | 0.77 | FALSE |
| 8 | GTEx | Testis | NRBP1 | 0.16 | 0.09 | lasso | 3 | 0.06 | 1.8e-03 | 4.8 | -6.3 | 3.9e-10 | 0.80 | 0.03 | 0.96 | FALSE |
| 9 | GTEx | Testis | AC074117.10 | 0.14 | 0.08 | lasso | 6 | 0.12 | 4.5e-06 | 3.7 | -6.6 | 3.8e-11 | 0.85 | 0.04 | 0.96 | FALSE |
| 10 | GTEx | Thyroid | FNDC4 | 0.24 | 0.10 | enet | 23 | 0.16 | 2.2e-12 | 4.7 | 7.0 | 2.0e-12 | -0.69 | 0.64 | 0.36 | FALSE |
| 11 | GTEx | Vagina | AC074117.10 | 0.14 | 0.04 | enet | 13 | 0.06 | 1.4e-02 | 3.2 | -5.4 | 8.1e-08 | 0.72 | 0.09 | 0.52 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | IFT172 | 0.07 | 0.02 | blup | 287 | 0.03 | 5.8e-05 | 4.4 | 6.8 | 1.3e-11 | -0.63 | 0.43 | 0.49 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GPN1 | 0.06 | 0.02 | lasso | 6 | 0.02 | 7.2e-05 | -6.7 | -6.0 | 2.7e-09 | 0.54 | 0.00 | 0.98 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SUPT7L | 0.05 | 0.02 | blup | 28 | 0.04 | 5.2e-05 | 4.2 | 5.5 | 3.9e-08 | -0.40 | 0.19 | 0.14 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FNDC4 | 0.13 | 0.06 | lasso | 2 | 0.05 | 1.1e-03 | -8.6 | 8.9 | 6.8e-19 | -0.99 | 0.00 | 0.95 | TRUE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | FNDC4 | 0.24 | 0.09 | enet | 9 | 0.17 | 1.9e-16 | 4.9 | 7.3 | 3.2e-13 | -0.70 | 0.43 | 0.57 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | GCKR | 0.18 | 0.08 | enet | 5 | 0.13 | 1.7e-12 | 4.7 | 6.8 | 9.7e-12 | -0.64 | 0.89 | 0.11 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | IFT172 | 0.08 | 0.01 | blup | 43 | 0.02 | 6.1e-03 | 5.5 | 5.8 | 4.9e-09 | -0.54 | 0.02 | 0.29 | FALSE |