[Hub]/) : Traits : Comparative height size at age 10 :

chr2:23,453,834-26,262,948

Best TWAS P=4.49e-25 · Best GWAS P=5.33e-31 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ADCY3 0.16 0.12 lasso 10 0.14 3.2e-17 -7.82 5.4 6.9e-08 0.27 1.00 0.00 TRUE
2 CommonMind Brain Pre-frontal Cortex CENPO 0.07 0.03 bslmm 322 0.03 7.0e-05 -1.02 7.1 9.5e-13 0.25 0.63 0.01 FALSE
3 GTEx Adipose Subcutaneous TP53I3 0.11 0.03 enet 48 0.04 3.8e-04 -1.38 6.0 2.5e-09 0.04 0.11 0.67 TRUE
4 GTEx Adipose Subcutaneous ADCY3 0.07 0.04 lasso 6 0.01 3.2e-02 -7.92 -7.8 6.8e-15 -0.32 0.83 0.01 FALSE
5 GTEx Adipose Subcutaneous RP11-443B20.1 0.04 0.00 enet 10 0.00 1.2e-01 -2.27 -5.3 1.1e-07 -0.28 0.36 0.05 FALSE
6 GTEx Adipose Visceral Omentum NCOA1 0.11 0.02 enet 17 0.02 2.1e-02 -8.12 -6.7 1.6e-11 -0.11 0.18 0.04 FALSE
7 GTEx Adipose Visceral Omentum UBXN2A 0.10 0.08 enet 29 0.03 9.8e-03 -7.22 -5.6 1.9e-08 -0.02 0.06 0.92 FALSE
8 GTEx Adrenal Gland PTRHD1 0.32 0.28 lasso 3 0.26 8.3e-10 9.15 -9.2 2.6e-20 -0.20 0.98 0.00 TRUE
9 GTEx Artery Aorta NCOA1 0.15 0.00 enet 15 0.01 1.4e-01 -8.05 -9.1 9.5e-20 -0.23 0.06 0.17 FALSE
10 GTEx Artery Tibial ADCY3 0.21 0.14 lasso 6 0.15 4.3e-12 -6.84 -6.8 1.1e-11 -0.27 1.00 0.00 FALSE
11 GTEx Artery Tibial UBXN2A 0.12 0.06 enet 24 0.09 1.5e-07 -2.79 -5.5 5.0e-08 -0.05 0.90 0.10 FALSE
12 GTEx Artery Tibial RP11-443B20.1 0.17 0.08 enet 40 0.09 8.2e-08 -6.84 -6.8 1.2e-11 -0.34 0.92 0.01 TRUE
13 GTEx Cells EBV-transformed lymphocytes ADCY3 0.25 0.23 enet 10 0.12 9.2e-05 -7.92 10.2 1.6e-24 0.38 0.77 0.05 FALSE
14 GTEx Cells EBV-transformed lymphocytes PFN4 0.18 0.13 lasso 12 0.12 8.9e-05 -4.98 -5.3 1.4e-07 0.00 0.34 0.05 FALSE
15 GTEx Cells EBV-transformed lymphocytes RP11-443B20.1 0.13 0.13 enet 9 0.05 9.2e-03 -7.92 9.2 4.4e-20 0.38 0.35 0.07 FALSE
16 GTEx Colon Sigmoid DNMT3A 0.19 -0.01 lasso 8 0.00 4.5e-01 -4.44 -9.1 9.9e-20 -0.40 0.05 0.40 TRUE
17 GTEx Colon Transverse UBXN2A 0.11 0.01 enet 8 0.03 8.7e-03 -5.86 -7.5 7.6e-14 -0.07 0.07 0.71 TRUE
18 GTEx Esophagus Mucosa TP53I3 0.16 0.03 enet 23 0.06 8.2e-05 0.95 -6.5 6.3e-11 -0.03 0.11 0.07 TRUE
19 GTEx Esophagus Muscularis NCOA1 0.11 0.01 enet 9 0.01 5.8e-02 -7.44 -10.3 4.5e-25 -0.17 0.08 0.05 TRUE
20 GTEx Heart Left Ventricle PFN4 0.23 0.28 lasso 6 0.28 4.1e-15 -5.00 -5.5 4.3e-08 -0.01 1.00 0.00 FALSE
21 GTEx Lung NCOA1 0.12 0.04 lasso 7 0.06 1.9e-05 -1.06 -6.0 2.3e-09 -0.10 0.52 0.02 FALSE
22 GTEx Lung UBXN2A 0.09 0.06 enet 7 0.07 6.1e-06 -2.73 -5.6 1.9e-08 -0.05 0.34 0.65 FALSE
23 GTEx Muscle Skeletal POMC 0.38 0.10 lasso 9 0.09 2.9e-09 2.16 5.7 1.6e-08 0.29 1.00 0.00 FALSE
24 GTEx Nerve Tibial ADCY3 0.09 0.05 enet 6 0.03 2.2e-03 -6.84 8.3 1.5e-16 0.35 0.96 0.00 FALSE
25 GTEx Nerve Tibial RP11-443B20.1 0.07 0.03 enet 6 0.02 1.1e-02 -6.84 6.6 3.5e-11 0.29 0.74 0.02 FALSE
26 GTEx Small Intestine Terminal Ileum UBXN2A 0.18 0.08 enet 33 0.16 2.5e-04 -7.11 -6.6 3.5e-11 -0.02 0.03 0.91 TRUE
27 GTEx Spleen UBXN2A 0.31 0.11 enet 19 0.17 4.1e-05 7.57 -8.5 1.7e-17 -0.06 0.04 0.92 FALSE
28 GTEx Whole Blood DNAJC27 0.08 0.10 lasso 1 0.10 2.2e-09 -7.53 -7.5 5.3e-14 -0.34 1.00 0.00 FALSE
29 GTEx Whole Blood ADCY3 0.23 0.24 enet 24 0.27 5.5e-25 -7.49 -7.4 1.9e-13 -0.32 1.00 0.00 FALSE
30 GTEx Whole Blood UBXN2A 0.17 0.07 lasso 8 0.09 2.1e-08 -2.74 -6.4 1.3e-10 -0.04 0.05 0.95 FALSE
31 GTEx Whole Blood RP11-443B20.1 0.21 0.17 enet 32 0.20 1.8e-18 -7.53 -7.0 2.6e-12 -0.32 1.00 0.00 FALSE
32 METSIM Adipose EFR3B 0.04 0.00 bslmm 357 0.00 9.7e-02 5.87 5.5 4.9e-08 -0.04 0.06 0.04 FALSE
33 NTR Blood ITSN2 0.02 0.00 bslmm 345 0.01 2.9e-03 -8.51 8.2 2.7e-16 0.06 0.05 0.05 TRUE
34 ROSMAP Brain Pre-frontal Cortex ADCY3 0.17 0.26 enet 32 0.26 6.8e-33 -7.49 7.8 4.0e-15 0.37 1.00 0.00 FALSE
35 ROSMAP Brain Pre-frontal Cortex CENPO 0.08 0.04 enet 5 0.05 2.6e-07 6.35 6.5 6.9e-11 0.16 1.00 0.00 FALSE
36 YFS Blood CENPO 0.09 0.06 lasso 6 0.07 6.7e-21 -8.27 8.6 8.8e-18 0.11 1.00 0.00 TRUE
37 YFS Blood POMC 0.35 0.05 enet 71 0.19 5.7e-59 9.52 7.1 1.2e-12 0.26 1.00 0.00 FALSE
38 The Cancer Genome Atlas Breast Invasive Carcinoma ADCY3 0.05 0.03 blup 81 0.03 5.0e-07 -8.59 7.7 1.9e-14 0.18 0.44 0.52 FALSE
39 The Cancer Genome Atlas Breast Invasive Carcinoma FKBP1B 0.04 0.02 blup 41 0.02 3.6e-05 -4.98 6.3 2.5e-10 0.01 0.43 0.06 FALSE
40 The Cancer Genome Atlas Glioblastoma Multiforme ADCY3 0.36 0.14 enet 7 0.13 8.9e-05 -8.04 8.0 1.3e-15 0.11 0.04 0.06 FALSE
41 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma POMC 0.06 0.00 enet 12 0.03 9.3e-05 0.35 5.2 2.0e-07 0.17 0.02 0.04 TRUE
42 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ADCY3 0.08 0.03 enet 16 0.03 1.5e-04 -8.54 8.3 1.0e-16 0.07 0.03 0.16 FALSE
43 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma EFR3B 0.03 0.05 lasso 1 0.04 1.9e-05 7.35 7.3 2.0e-13 0.34 0.17 0.72 FALSE
44 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma NCOA1 0.08 0.07 blup 77 0.05 5.8e-04 0.32 -5.3 1.1e-07 -0.07 0.27 0.04 FALSE
45 The Cancer Genome Atlas Brain Lower Grade Glioma ADCY3 0.03 0.02 blup 81 0.02 7.1e-04 -7.50 8.1 5.2e-16 0.34 0.51 0.03 FALSE
46 The Cancer Genome Atlas Lung Adenocarcinoma DNAJC27 0.05 0.01 blup 46 0.04 3.2e-05 -3.19 6.6 5.5e-11 0.27 0.44 0.49 FALSE
47 The Cancer Genome Atlas Lung Adenocarcinoma NCOA1 0.02 0.01 blup 77 0.01 1.2e-02 1.30 5.2 2.1e-07 0.15 0.04 0.66 FALSE
48 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ADCY3 0.06 0.01 enet 9 0.02 1.0e-03 -8.51 5.5 3.6e-08 0.04 0.05 0.06 FALSE
49 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma POMC 0.19 0.01 blup 38 0.05 1.5e-04 9.52 6.7 2.1e-11 0.31 0.02 0.06 TRUE
50 The Cancer Genome Atlas Pancreatic Adenocarcinoma EFR3B 0.26 0.01 lasso 4 0.05 3.8e-03 -7.44 -8.0 1.9e-15 -0.21 0.03 0.11 FALSE
51 The Cancer Genome Atlas Prostate Adenocarcinoma ADCY3 0.09 0.02 enet 11 0.04 3.2e-05 -8.04 6.1 1.2e-09 -0.02 0.12 0.05 FALSE
52 The Cancer Genome Atlas Rectum Adenocarcinoma PFN4 0.38 0.11 lasso 5 0.05 2.8e-02 -4.98 -5.3 1.4e-07 -0.01 0.01 0.56 FALSE