Best TWAS P=3.36e-14 · Best GWAS P=3.21e-24 conditioned to 7.16e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | KIF17 | 0.25 | 0.19 | bslmm | 476 | 0.21 | 8.2e-25 | -6.0 | 5.7 | 1.0e-08 | -0.35 | 0.94 | 0.06 | FALSE |
| 2 | GTEx | Artery Aorta | CAPZB | 0.14 | 0.10 | lasso | 6 | 0.10 | 5.0e-06 | 5.5 | -5.1 | 2.8e-07 | 0.00 | 0.57 | 0.42 | FALSE |
| 3 | GTEx | Artery Tibial | CAPZB | 0.09 | 0.07 | lasso | 4 | 0.06 | 8.1e-06 | 4.7 | -5.7 | 1.2e-08 | -0.03 | 0.20 | 0.73 | FALSE |
| 4 | GTEx | Brain Caudate basal ganglia | KIF17 | 0.22 | 0.18 | lasso | 3 | 0.19 | 4.7e-06 | -5.8 | 5.8 | 5.7e-09 | -0.34 | 0.03 | 0.88 | FALSE |
| 5 | GTEx | Brain Cerebellum | HP1BP3 | 0.27 | 0.07 | lasso | 4 | 0.03 | 3.8e-02 | 5.1 | 5.5 | 2.9e-08 | -0.25 | 0.08 | 0.10 | FALSE |
| 6 | GTEx | Breast Mammary Tissue | PQLC2 | 0.19 | 0.04 | lasso | 3 | 0.04 | 4.0e-03 | -5.9 | 5.3 | 1.3e-07 | 0.01 | 0.03 | 0.82 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | EIF4G3 | 0.23 | 0.06 | lasso | 6 | 0.03 | 1.1e-02 | -7.6 | -7.6 | 3.4e-14 | 0.43 | 0.36 | 0.16 | TRUE |
| 8 | GTEx | Nerve Tibial | PQLC2 | 0.07 | 0.08 | lasso | 3 | 0.06 | 6.6e-05 | -5.9 | 5.9 | 3.0e-09 | 0.07 | 0.03 | 0.96 | FALSE |
| 9 | GTEx | Small Intestine Terminal Ileum | KIF17 | 0.24 | 0.04 | lasso | 7 | 0.02 | 1.3e-01 | -6.9 | -6.8 | 1.4e-11 | 0.40 | 0.02 | 0.80 | FALSE |
| 10 | GTEx | Testis | KIF17 | 0.19 | 0.23 | lasso | 4 | 0.23 | 9.7e-11 | -5.8 | 5.9 | 4.3e-09 | -0.35 | 0.87 | 0.13 | FALSE |
| 11 | GTEx | Uterus | ALPL | 0.42 | -0.01 | lasso | 8 | 0.02 | 1.4e-01 | 1.3 | -7.1 | 1.7e-12 | 0.33 | 0.04 | 0.21 | TRUE |
| 12 | GTEx | Whole Blood | HP1BP3 | 0.04 | 0.04 | lasso | 4 | 0.02 | 6.3e-03 | -6.2 | -6.4 | 1.7e-10 | 0.42 | 0.71 | 0.06 | FALSE |
| 13 | GTEx | Whole Blood | RP5-930J4.4 | 0.07 | 0.09 | lasso | 5 | 0.09 | 1.0e-08 | -6.2 | -6.2 | 5.7e-10 | 0.39 | 0.38 | 0.62 | FALSE |
| 14 | The Cancer Genome Atlas | Esophageal Carcinoma | KIF17 | 0.16 | 0.07 | blup | 92 | 0.07 | 3.6e-03 | 4.7 | 5.5 | 3.0e-08 | -0.17 | 0.05 | 0.04 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CAPZB | 0.03 | 0.00 | blup | 160 | 0.01 | 3.3e-02 | -6.2 | -6.9 | 5.4e-12 | -0.06 | 0.02 | 0.89 | TRUE |
| 16 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PINK1 | 0.08 | 0.04 | blup | 94 | 0.04 | 5.3e-03 | -4.0 | 5.5 | 3.8e-08 | -0.10 | 0.01 | 0.44 | TRUE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | CAPZB | 0.08 | 0.06 | blup | 160 | 0.07 | 1.2e-07 | 4.7 | -5.2 | 2.4e-07 | -0.04 | 0.71 | 0.28 | FALSE |