Hub : Genes

C1orf210

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0816	0.0280	5.2e-12	0.133	0.119	0.128	NA	0.126	1.0e-14	2.8e-13	2.9e-14	NA	5.0e-14
2	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1020	0.0480	3.8e-04	0.029	0.041	0.012	NA	0.014	8.1e-03	2.1e-03	6.8e-02	NA	4.9e-02
3	TCGA	Prostate Adenocarcinoma	0.0345	0.0195	5.0e-03	0.006	0.005	0.010	NA	0.000	7.7e-02	7.9e-02	2.6e-02	NA	2.9e-01
4	TCGA	Rectum Adenocarcinoma	0.1720	0.0870	9.2e-03	0.121	0.098	0.064	NA	0.094	9.4e-04	2.7e-03	1.3e-02	NA	3.3e-03
5	TCGA	Thyroid Carcinoma	0.0420	0.0220	2.6e-03	0.021	0.013	0.012	NA	0.014	3.6e-03	1.6e-02	2.0e-02	NA	1.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.6	2.5	3.2	1.5	1.8	1.5	-1.3	-1.8
Bipolar Disorder or Schizophrenia	3.9	9.5	16.0	3.0	3.0	2.8	-2.3	-4.0
Depressed Affect (Nagel 2018)	0.2	0.4	0.8	0.9	0.4	0.7	-0.8	0.1
Depression (Nagel 2018)	0.7	1.1	1.3	1.1	0.9	1.1	-1.0	-1.0
Intelligence (Savage-Jansen 2018)	1.4	4.4	7.5	-1.7	-1.4	-2.3	2.1	2.7
Neuroticism (Nagel 2018)	0.4	0.9	3.0	-0.3	-0.0	-1.3	0.1	1.7
Schizophrenia (2018)	3.5	7.3	13.9	2.7	2.4	2.5	-2.0	-3.7
Schizophrenia vs Biploar Disorder	0.9	1.2	2.5	-1.6	-0.4	-0.4	1.6	-0.8
Worry (Nagel 2018)	0.7	1.4	3.5	-0.3	-0.0	-1.8	0.7	1.9
Alzheimer’s Disease (in mother)	0.2	0.2	0.8	0.2	-0.1	0.2	-0.5	-0.9
Alzheimer’s Disease (in father)	0.4	0.5	1.0	1.0	0.5	0.5	-0.9	0.1
Alzheimer’s Disease (including proxy)	0.5	0.7	0.9	0.9	0.6	0.9	-0.8	-0.9
Crohns Disease (2017)	0.4	0.9	1.7	-0.5	1.3	-0.8	0.9	-1.1
Irritable Bowel Disease (IBD)	0.5	1.3	3.1	-0.4	1.6	-0.3	0.7	-1.8
Ulcerative Colitis (UC)	0.5	0.9	2.9	-0.6	0.8	0.2	0.7	-1.7
Major Depression (MDD)	2.2	2.7	4.7	1.5	1.6	2.2	-0.2	-2.0
Reaction Time	0.9	1.7	5.1	0.0	-0.9	-1.3	-0.9	2.2
Verbal and Numeric Reasoning (VNR)	1.5	3.5	5.8	-1.7	-1.8	-1.7	1.6	2.4
Breast Cancer	0.4	0.9	2.9	-0.2	-0.2	1.7	-0.2	-1.2
Ovarian Cancer	0.4	0.5	1.9	0.2	-0.1	-1.4	-0.5	0.6
Prostate Cancer	0.3	0.4	1.2	-0.2	-0.2	1.0	-0.1	-1.1
Age at First Birth	1.1	1.6	3.1	-1.2	-1.6	-0.3	0.7	1.8
Bipolar Disorder (2011)	1.6	1.5	2.5	1.6	1.2	0.0	-1.3	-1.3
Body Mass Index (BMI) (2010)	0.7	0.9	1.6	1.1	1.3	-0.2	-1.3	0.0
Coronary Artery Disease (CAD)	1.2	1.4	6.4	-0.6	0.0	0.0	0.7	2.5
Crohns Disease (2012)	0.7	1.2	2.9	0.4	1.6	0.0	0.4	-1.7
Mean Putamen Volume	0.3	0.4	1.4	-0.7	0.1	-0.0	1.2	-0.4
Fasting Glucose	0.9	1.1	2.6	-1.5	-0.6	-0.5	1.6	-0.0
HbA1C	0.1	0.1	0.2	-0.2	0.0	0.3	0.2	0.4
HDL Cholesterol	0.6	1.0	2.1	0.7	0.6	1.4	-0.4	-1.4
LDL Cholesterol	0.7	1.1	2.0	-1.2	-1.1	0.4	1.4	-0.6
Lupus	0.4	0.7	2.9	-0.6	-0.2	0.0	1.7	0.1
Neuroticism (2016)	2.3	3.3	4.4	2.1	1.5	-1.6	-1.9	2.0
Primary Biliary Cirrhosis	0.4	0.6	1.3	-0.6	-1.1	0.1	0.3	1.0
Rheumatoid Arthritis	0.4	0.5	1.7	-0.2	1.0	-1.3	0.0	0.0
Schizophrenia (2014)	1.9	4.2	9.5	1.6	1.6	2.2	-1.3	-3.1
Triglycerides	0.2	0.3	0.7	-0.8	-0.7	0.4	0.5	0.1
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.9	-0.8	-0.1	0.4	0.9	-0.3
Ulcerative Colitis	1.2	1.8	5.9	0.2	1.2	0.9	0.8	-2.4
Blood Eosinophil Count	0.1	0.9	1.6	0.2	-0.9	-1.2	-0.7	1.3
Blood Platelet Count	0.7	7.9	15.8	2.4	3.3	-4.0	-2.2	1.5
Blood Red Count	2.4	22.9	61.2	-1.5	-2.4	-6.7	-0.3	7.8
Blood White Count	1.3	9.7	26.0	0.7	-0.1	-4.5	-1.3	5.1
Heel T-Score	0.1	0.4	1.2	-0.6	0.2	0.4	0.5	-1.1
BMI	0.4	2.4	4.2	-1.0	-1.7	-1.9	0.3	2.1
Height	0.7	12.8	40.8	-2.1	-3.5	-2.4	0.4	6.4
Waist Hip Ratio (WHR)	0.2	0.8	1.6	-0.7	-0.2	-1.3	0.9	1.1
Systolic Blood Pressure	4.5	22.5	62.7	-1.2	-2.0	-6.6	-0.6	7.9
Smoking Status	0.7	1.6	5.6	0.1	0.6	1.2	0.9	-2.4
Allergy or Eczema	0.2	0.5	1.7	0.5	1.3	-0.1	-0.2	-0.5
Cardiovascular Disease	1.9	6.1	17.8	-1.3	-2.4	-2.4	-0.2	4.2
Hypothyroidism (self reported)	0.9	2.2	3.7	-0.8	-1.9	-1.7	-0.1	1.9
Respiratory disease	0.9	2.1	3.1	1.1	1.7	-1.6	-1.1	1.5
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.0	1.0	0.8	1.4	-0.8	-1.2
Lung FEV1/FVC ratio	0.1	0.6	1.1	0.7	0.6	-0.8	-0.7	1.0
Lung FVC	0.1	0.3	0.6	-0.6	-0.1	-0.3	0.6	-0.8
Neuroticism	0.3	0.6	2.3	0.4	0.2	-0.7	-0.3	1.5
Chronotype (morning person)	1.5	3.4	4.9	-2.2	-2.2	-1.2	1.9	1.5
Hair Pigment	0.0	0.2	0.6	0.5	0.7	-0.4	-0.2	-0.5
Tanning	0.0	0.5	1.1	0.3	1.0	-1.0	0.2	-0.8
Hand grip strength (left)	0.3	0.8	1.6	-0.8	-1.2	-0.6	0.0	1.3
Number of treatments/medications taken	0.5	0.9	2.8	0.5	-0.2	-0.9	-0.6	1.7
Average weekly spirits intake	0.7	0.8	1.6	-0.4	1.0	-0.8	0.9	-1.3
Sensitivity / hurt feelings	0.7	1.2	2.0	0.9	0.7	-0.9	-1.4	1.4
Frequency of depressed mood in last 2 weeks	1.9	2.7	4.8	2.1	1.4	1.0	-2.2	-1.1
Hearing difficulty/problems: Yes	1.0	1.6	6.2	-0.1	0.2	1.3	0.2	-2.5
Relative age of first facial hair	1.3	2.7	7.5	0.7	0.4	2.2	-0.9	-2.7
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.4	-1.2	-1.2	0.1	0.9	-0.2
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.5	-0.3	-0.7	-1.3	-0.4	1.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.4	0.4	-0.1	-0.3	0.4
Systolic blood pressure, automated reading	3.8	11.0	25.5	-1.6	-1.6	-4.9	0.3	5.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.0	0.1	0.5	1.0	-0.6	-0.7
Angina	3.0	4.0	9.8	-0.4	-1.0	-3.1	-0.5	3.0
Medication for hormone replacement therapy	0.4	0.4	1.0	0.8	1.0	0.1	-0.5	-0.6
Vitamin and mineral supplements	0.7	0.9	1.9	-0.7	-0.4	0.8	1.2	-1.4
Supplements: Zinc	3.3	3.6	5.7	2.4	2.1	1.5	-2.1	-0.9
Medication: Co-codamol	1.4	1.7	2.7	-1.4	-0.7	-1.4	1.1	1.6
Medication: Metformin	1.8	2.6	3.5	1.9	1.6	1.4	-1.3	-1.8
Diabetes (father)	0.7	0.9	1.5	0.9	0.4	-1.0	-1.2	0.9
Diabetes (mother)	0.2	0.3	0.9	0.6	0.1	0.1	-1.0	0.0
Severe depression (siblings)	0.4	0.5	0.9	0.6	-0.4	0.6	-0.7	0.9
Pack years adult smoking proportion	0.7	1.1	3.1	0.3	-0.0	1.4	-0.2	-1.8
Impedance of leg (right)	0.4	2.0	4.6	1.8	2.1	-0.3	-1.4	0.3
Leg fat-free mass (left)	0.9	4.9	8.0	-2.0	-2.4	-2.4	1.1	2.8
Trunk fat percentage	0.6	2.3	5.0	-1.5	-1.0	-2.2	1.5	1.1
Hand grip strength (right)	0.7	2.0	4.0	-1.0	-1.5	-1.6	0.2	2.0
Townsend deprivation index at recruitment	1.3	1.9	4.5	1.0	1.1	1.5	-0.6	-2.1
Current tobacco smoking	2.2	3.6	6.0	1.9	1.8	1.9	-1.3	-2.5
Average weekly fortified wine intake	0.9	1.0	2.3	-1.5	-0.3	-0.8	1.4	-0.1
Maternal smoking around birth	2.7	4.0	12.5	-1.1	-0.7	2.1	0.9	-3.5
Fed-up feelings	0.6	1.0	2.0	1.4	0.8	0.3	-1.3	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.5	0.7	0.5	0.8	-1.0	-1.6
Relative age voice broke	0.7	1.1	2.5	1.0	1.2	0.5	-0.7	-1.6
Taking other prescription medications	0.1	0.1	0.4	0.6	0.1	0.2	-0.2	0.2
Age when periods started (menarche)	3.5	8.5	13.9	2.4	2.5	3.4	-2.3	-3.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.6	0.4	0.7	-0.1	-0.8	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.7	0.5	-0.1	0.0	-0.8	0.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.3	1.0	1.2	0.1	-0.6	-0.3
Qualifications: CSEs or equivalent	0.4	0.5	1.1	-1.0	-0.6	0.1	0.1	-1.0
Serious illness, injury or assault to yourself	0.9	1.1	1.7	1.0	0.6	1.3	-1.2	-1.0
High blood pressure	1.7	4.6	13.2	-0.9	-1.9	-2.3	-0.3	3.6
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.6	0.9	1.6	0.1	-0.5	-0.9
Multivitamins +/- minerals	0.1	0.2	0.5	0.0	0.7	-0.6	0.0	-0.1
Stomach or abdominal pain in last month	1.8	2.2	4.7	2.2	1.7	0.7	-1.7	-0.6
Supplements: Glucosamine	0.8	1.0	2.9	1.1	0.9	0.3	-1.7	-0.3
Diverticular disease/diverticulitis (self-reported)	1.1	1.4	4.0	1.3	2.0	0.3	-0.5	-0.9
Medication: Atenolol	0.7	0.9	1.3	1.0	0.9	-0.6	-1.0	1.1
Medication: Levothyroxine sodium	3.0	5.1	11.3	-2.6	-3.4	-1.6	1.3	1.9
Sitting height	0.6	4.2	14.7	-0.8	-1.1	-2.1	-0.0	3.8
Chronic bronchitis/emphysema (father)	0.6	0.7	1.7	0.7	-0.7	1.3	-0.8	-0.6
High blood pressure (mother)	1.6	2.2	8.5	0.2	-0.2	-1.6	-0.1	2.9
Body mass index (BMI)	0.2	0.8	1.6	-0.9	-1.0	-1.3	0.7	0.4
Impedance of leg (left)	0.4	2.1	4.7	1.8	2.2	-0.2	-1.5	0.3
Leg predicted mass (left)	0.9	4.8	7.8	-1.9	-2.3	-2.4	1.1	2.8
Trunk fat mass	0.7	3.1	5.6	-1.7	-1.6	-2.4	1.3	1.7
Waist circumference	0.5	1.7	3.2	-1.2	-1.2	-1.8	0.9	1.3
Number of incorrect matches in round	0.3	0.5	1.4	-0.1	0.3	1.2	0.0	-1.0
Past tobacco smoking	0.2	0.4	0.6	-0.4	-0.7	0.7	-0.6	0.7
Alcohol usually taken with meals	3.1	5.0	16.9	-0.1	-1.4	-2.3	-0.9	4.1
Nervous feelings	0.4	0.7	1.9	0.3	0.6	-1.4	-0.2	1.0
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.1	4.1	1.5	1.8	0.1	-2.0	-0.8
Hearing difficulty/problems with background noise	0.4	0.6	1.7	0.9	1.3	0.0	-0.5	-0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.4	-0.2	0.1	-0.4	-0.3
Had menopause	1.8	2.2	4.2	-1.2	-1.1	-2.1	0.9	1.9
Had other major operations	0.3	0.4	1.6	0.5	-0.1	0.1	-0.0	1.2
Forced vital capacity (FVC)	0.7	2.8	6.0	-1.2	-1.1	-2.3	0.7	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	0.4	0.4	-0.0	-0.5	0.6
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.2	0.5	-0.1	1.0	-0.8	-1.5
Qualifications: None of the above	2.0	4.2	13.2	1.3	2.2	1.0	-0.2	-3.6
Financial difficulties in last 2 years	0.7	0.9	2.2	1.1	0.5	0.5	-1.5	-0.7
Mouth/teeth dental problems	1.0	1.6	3.8	-0.8	0.1	-1.9	1.0	1.6
Heart attack	1.0	1.3	2.7	-1.0	-1.6	-0.5	0.3	1.5
Allergy	0.6	1.3	3.3	-1.4	-1.8	0.4	1.0	0.3
Pain all over the body in last month	0.5	0.6	0.9	0.9	0.8	0.4	-0.6	-0.9
Diabetes (self-reported)	1.3	1.9	4.0	1.0	1.0	1.8	-0.8	-2.0
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.3	-0.8	-0.2	0.9	1.5	-1.5
Medication: Ramipril	1.0	1.3	3.9	-0.5	-1.4	-0.6	-0.1	2.0
Medication: Simvastatin	0.5	0.8	2.0	-0.4	-0.6	1.4	0.6	-1.0
Fluid intelligence score	1.2	2.6	4.9	-1.6	-1.5	-0.9	1.5	2.2
Illnesses of siblings	0.2	0.2	0.4	-0.1	0.5	0.5	0.6	-0.6
Neuroticism score	0.2	0.5	1.2	0.8	0.4	-0.3	-1.1	0.7
Weight	0.8	3.8	7.4	-1.3	-1.8	-2.5	0.4	2.7
Impedance of arm (right)	0.1	0.6	1.2	-0.8	-0.2	-1.1	0.8	0.9
Arm fat percentage (right)	0.5	1.9	3.3	-1.5	-1.4	-1.8	1.2	0.9
Trunk fat-free mass	0.5	2.8	7.7	-0.9	-1.9	-1.3	-0.3	2.8
Hip circumference	0.7	2.8	5.5	-1.1	-1.5	-2.3	0.5	2.3
Time employed in main current job	1.5	1.7	4.6	-0.8	-0.6	-2.1	0.2	1.7
Alcohol intake versus 10 years previously	0.2	0.3	1.1	0.1	-0.0	0.2	-0.4	-1.0
Father’s age at death	1.0	1.4	2.2	0.9	1.1	1.5	-0.8	-1.4
Worrier / anxious feelings	0.9	1.7	4.5	-0.9	-0.5	-1.6	0.9	2.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.4	-0.6	-0.4	-0.2	1.2	-0.4
Falls in the last year	0.6	0.8	1.2	0.9	1.1	0.4	-1.1	-0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	-0.5	-0.4	-0.6	-0.2	0.8
Number of live births	0.3	0.5	1.3	0.6	1.1	-0.7	-0.2	-0.4
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	7.0	-1.0	-0.6	-2.6	0.6	2.6
Pulse rate	0.1	0.2	0.3	-0.6	-0.5	-0.2	0.4	0.1
Happiness	2.8	3.4	5.9	2.2	1.6	1.4	-2.4	-1.2
Noisy workplace	4.2	5.2	10.3	1.5	0.9	3.2	-1.7	-3.1
Qualifications: A levels/AS levels or equivalent	1.6	3.4	11.8	-1.0	-1.6	-1.2	0.7	3.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	-0.2	-0.1	0.4	0.6	-0.1
Mouth/teeth dental problems: Dentures	0.2	0.3	1.0	-0.4	-0.6	-0.3	-0.2	-1.0
Asthma	0.3	0.6	1.2	0.7	1.1	-0.9	-0.2	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.9	-0.0	0.2	-1.0	-0.1	0.3
Medication: Cholesterol lowering	0.4	0.7	2.6	0.6	-0.1	1.6	-0.5	-0.4
Depression (self-reported)	1.0	1.2	2.8	0.4	0.5	1.7	-0.1	-1.6
Medication: Lansoprazole	2.3	2.7	8.5	0.8	-0.4	2.9	-1.2	-1.6
Prospective memory result	0.1	0.2	0.5	0.7	0.5	0.2	-0.4	-0.1
Lung cancer (father)	1.0	1.2	2.8	0.5	-0.1	1.7	-0.6	-1.6
Illnesses of mother	1.2	1.5	2.6	0.8	1.3	1.2	-1.1	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	5.1	-0.5	-0.7	-1.8	0.2	2.3
Pulse wave Arterial Stiffness index	2.1	2.4	5.5	-2.1	-2.3	-0.4	1.2	0.6
Impedance of arm (left)	0.1	0.7	1.0	-0.8	-0.2	-1.0	0.9	0.8
Arm fat mass (right)	0.7	2.9	4.9	-1.6	-1.7	-2.2	1.0	1.7
Trunk predicted mass	0.5	2.9	8.1	-0.9	-1.9	-1.3	-0.3	2.8
Standing height	0.8	7.7	26.3	-1.0	-1.9	-2.6	-0.6	5.1
Length of working week for main job	1.8	2.0	3.5	-1.9	-1.2	-1.6	1.4	0.6
Exposure to tobacco smoke at home	1.4	1.5	2.9	1.2	-0.2	1.7	-1.6	-0.8
Breastfed as a baby	0.7	0.9	2.5	-0.1	1.6	0.2	0.9	-1.0
Tense / ‘highly strung’	0.1	0.1	0.3	-0.2	-0.3	-0.5	0.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.3	-0.3	-0.2	1.8	1.0	-1.7
Hair/balding pattern: Pattern 4	0.6	1.4	4.0	-0.7	-0.7	-1.2	0.6	2.0
Birth weight of first child	0.1	0.1	0.5	-0.4	-0.0	-0.0	0.2	-0.7
Peak expiratory flow (PEF)	1.6	3.8	9.5	-0.9	-0.5	-2.7	0.8	3.1
Pulse wave reflection index	3.1	3.8	5.4	-2.3	-2.3	-1.8	1.4	1.7
Ever highly irritable/argumentative for 2 days	1.3	1.6	3.4	-1.4	-0.2	-0.3	1.9	-1.6
Loud music exposure frequency	0.5	0.6	2.0	0.9	0.3	-0.0	-1.4	0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	0.5	0.1	0.7	-0.2	0.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	-0.2	-0.2	0.9	0.7	-0.7
Blood clot in the leg (DVT)	0.5	0.6	1.1	-0.6	-1.0	-1.1	0.8	0.4
Medication: Paracetamol	1.7	2.8	3.6	-1.9	-1.7	-1.8	1.6	1.4
Headache pain in last month	1.2	2.0	4.5	-2.0	-1.1	-0.5	2.1	0.6
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	2.9	-0.3	1.0	-1.7	0.5	-0.7
Glaucoma (self-reported)	0.2	0.3	0.7	-0.2	-0.3	-0.5	-0.5	0.8
Gout (self-reported)	0.4	0.5	1.2	0.9	-0.0	-0.1	-1.1	0.6
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	6.2	-1.4	-2.5	-0.9	0.6	1.4
Medication: Amlodipine	2.5	3.5	6.0	-2.5	-2.4	-0.1	2.2	0.8
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.1	1.1	0.8	0.7	-0.8	-0.2
Birth weight	1.7	3.8	5.7	1.7	2.0	2.3	-1.1	-2.4
Chronic bronchitis/emphysema (mother)	3.3	3.9	14.1	-0.4	0.3	2.0	1.0	-3.8
High blood pressure (siblings)	0.2	0.4	0.9	0.6	-0.3	-0.1	-0.6	1.0
Forced vital capacity (FVC), Best measure	0.4	1.4	4.1	-0.7	-1.0	-1.3	0.2	2.0
Body fat percentage	0.3	1.2	3.5	-0.9	-0.6	-1.9	1.0	0.7
Leg fat percentage (right)	0.2	0.6	2.6	0.2	0.3	-1.6	-0.2	0.6
Arm fat-free mass (right)	0.5	2.7	7.7	-0.6	-1.2	-2.0	-0.2	2.8
Exposure to tobacco smoke outside home	0.3	0.4	0.9	-0.6	0.1	-0.3	0.9	-1.0
Comparative body size at age 10	1.7	4.6	13.1	0.8	0.9	2.9	-0.1	-3.6
Number of full brothers	0.9	1.2	2.2	1.5	1.1	0.4	-1.4	-0.6
Worry too long after embarrassment	2.3	3.8	5.3	-2.3	-1.9	-2.1	1.3	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.4	0.2	-0.5	1.9	-0.0	-0.8
Wheeze or whistling in the chest in last year	0.2	0.4	1.0	0.2	-0.1	-0.7	-0.5	1.0
Number of children fathered	0.2	0.2	0.4	-0.3	-0.5	-0.7	0.3	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	-0.6	0.2	-0.5	0.5	0.2
Age at first live birth	0.2	0.4	1.6	-0.0	-0.4	-0.2	-0.3	1.3
Pulse wave peak to peak time	1.9	2.3	5.3	2.1	2.3	0.1	-1.3	-0.2
Health satisfaction	3.8	5.0	8.8	3.0	2.8	0.5	-2.6	-1.1
Shortness of breath walking on level ground	0.2	0.3	0.7	-0.5	0.2	-0.8	0.6	-0.0
Qualifications: College or University degree	2.2	6.9	21.6	-1.8	-2.8	-1.2	0.2	4.7
Eye problems/disorders: None of the above	0.1	0.2	0.4	0.6	0.0	0.1	0.1	0.7
Mouth/teeth dental problems: Loose teeth	1.5	1.8	4.3	1.7	0.4	1.2	-2.1	0.0
Emphysema/chronic bronchitis	0.5	0.6	1.3	1.0	1.1	0.1	-0.9	0.0
Medication for pain relief, constipation, heartburn	0.7	1.2	3.2	0.0	0.7	1.5	0.3	-1.8
Neck or shoulder pain in last month	0.6	0.8	1.9	0.9	0.3	0.9	-1.4	-0.7
Medication: Blood pressure	0.6	1.1	3.3	-0.6	-1.8	0.7	0.1	1.2
Angina (self-reported)	3.0	3.9	9.1	-0.8	-1.3	-3.0	-0.2	2.9
Migraine (self-reported)	0.7	0.9	3.3	-1.0	-0.3	0.1	1.8	-0.4
Medication: Ibuprofen	0.5	0.6	1.6	-0.1	-0.2	-1.3	-0.4	1.1
Medication: Allopurinol	1.7	2.3	4.3	2.0	1.6	0.3	-2.1	0.1
Medication: Omeprazole	2.0	2.4	5.1	1.8	1.9	-0.2	-2.2	-0.3
Medication: Seretide 50 evohaler	0.8	0.9	2.2	1.4	0.4	0.2	-1.5	0.5
Mean time to correctly identify matches	0.9	1.7	4.5	0.1	-0.4	-1.6	-1.1	2.1
Heart disease (mother)	6.3	7.7	10.8	-2.9	-3.3	-1.9	2.5	3.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.7	-0.9	0.1	-1.0	1.6	0.2
Whole body fat mass	0.6	2.4	5.3	-1.2	-1.3	-2.3	0.9	1.7
Leg fat mass (right)	0.4	1.7	5.3	-0.7	-0.9	-2.3	0.4	1.4
Arm predicted mass (right)	0.5	2.5	6.7	-0.9	-1.4	-1.8	-0.0	2.6
Pulse rate, automated reading	1.5	4.7	8.7	-1.8	-1.7	-2.5	1.5	3.0
Alcohol intake frequency.	0.6	1.5	6.1	-0.1	0.8	0.3	0.7	-2.5
Comparative height size at age 10	1.6	8.8	27.8	-1.8	-2.6	-2.5	0.5	5.3
Number of full sisters	0.4	0.5	1.2	-0.9	-0.6	-0.1	1.1	-0.2
Suffer from ‘nerves’	0.2	0.3	1.0	-0.0	0.7	-1.0	0.4	0.2
Overall health rating	1.0	2.2	3.6	1.9	1.2	1.1	-1.5	-1.5
Chest pain or discomfort	0.2	0.4	0.8	0.7	0.2	0.9	-0.7	-0.2
Had major operations	0.1	0.1	0.2	0.3	-0.0	-0.1	-0.5	-0.0
Age at last live birth	0.5	0.8	2.2	-0.0	-0.4	-1.0	-0.7	1.5
Family relationship satisfaction	1.2	1.5	2.7	1.6	0.6	1.3	-1.4	-1.0
Leg pain on walking	0.1	0.2	0.5	0.1	0.7	-0.6	-0.1	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.9	0.7	0.1	-0.1	-1.0	-0.1
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.2	-0.1	-0.1	-0.1	0.4	-0.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.0	-0.4	-0.2	-1.2	0.4	1.4
Medication: Aspirin	1.3	1.7	3.4	1.7	0.6	-0.4	-1.9	1.2
Supplements: Vitamin C	1.9	2.2	6.4	1.7	0.5	0.1	-2.5	1.3
Knee pain experienced in last month	0.3	0.5	1.3	-0.3	-0.6	-1.1	0.5	0.7
Hypertension (Self-reported)	1.1	3.1	9.0	-0.8	-1.5	-1.9	-0.2	3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	4.8	2.2	1.6	1.4	-1.4	-1.7
Illnesses of father: Heart disease	2.3	3.2	10.3	-0.8	-0.8	-2.1	-0.1	3.2
Illnesses of siblings: Diabetes	0.5	0.6	2.4	0.2	0.4	0.6	0.1	-1.5
Smoking status: Previous	0.1	0.2	0.8	-0.1	0.0	-0.3	0.9	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	5.8	0.4	-0.6	-1.0	-1.7	2.4
Whole body fat-free mass	0.6	3.5	7.7	-1.4	-2.1	-1.8	0.3	2.8
Leg fat-free mass (right)	0.8	4.2	7.0	-1.9	-2.2	-2.2	1.0	2.6
Arm fat percentage (left)	0.6	2.3	4.4	-1.5	-1.5	-2.1	1.2	1.2
Average weekly red wine intake	2.1	3.1	7.8	-1.3	-0.8	-2.8	1.3	1.9
Handedness (chirality/laterality): Left-handed	1.9	2.3	3.1	1.5	1.2	1.8	-1.6	-1.5
Mood swings	1.8	3.3	6.3	2.5	1.7	1.0	-2.5	-0.6
Loneliness, isolation	0.8	1.1	2.9	1.3	1.0	-0.1	-1.7	-0.2
Long-standing illness, disability or infirmity	0.2	0.3	0.6	0.3	-0.6	-0.2	-0.6	0.8
Ever had bowel cancer screening	0.3	0.3	0.6	-0.8	-0.7	0.3	0.7	-0.1
Diabetes diagnosed by doctor	0.6	0.9	1.9	0.6	0.7	1.4	-0.6	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.4	-1.2	-0.7	-0.9	1.1	0.1
Friendships satisfaction	2.3	2.9	4.9	1.5	0.7	2.2	-1.7	-1.9
Qualifications: nursing, teaching	0.2	0.3	0.9	0.1	0.0	0.8	0.3	0.9
Commuting to job workplace: Walk	0.5	0.5	0.9	0.8	0.3	1.0	-1.0	-0.2
Eye problems/disorders: Cataract	1.1	1.3	2.4	1.1	1.4	-0.4	-1.6	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	4.4	-0.6	-0.8	2.1	0.4	-1.1
Medication for cholesterol	0.6	0.9	2.6	0.3	0.2	1.6	-0.1	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.1	0.1	-0.4	-0.1	-0.0	0.1
Back pain experienced in last month	0.2	0.3	0.5	0.3	0.2	0.5	-0.6	-0.7
Mineral and other dietary supplements	1.1	1.4	2.1	-1.0	-1.4	1.5	1.1	-0.9
Breast cancer (self-reported)	1.1	1.3	2.6	-1.6	-1.1	0.0	1.5	0.4
Asthma (self-reported)	0.4	0.8	1.6	1.0	1.3	-0.8	-0.3	0.8
Osteoporosis (self-reported)	0.1	0.2	0.6	0.8	0.4	0.1	-0.1	-0.1
Osteoarthritis (self-reported)	0.7	1.0	2.0	1.4	0.4	0.6	-1.4	0.5
Medication: Aspirin	0.9	1.2	2.2	1.5	0.4	-0.3	-1.5	1.1
Medication: Gliclazide	0.8	1.0	1.6	1.3	0.9	1.0	-1.0	-0.7
Illnesses of father: None of the above (group 1)	1.2	1.5	3.8	0.5	0.4	1.8	-0.2	-1.9
Smoking status: Current	1.8	2.8	4.7	1.7	1.7	1.4	-1.3	-2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.8	-0.1	0.7	-0.9	0.9	0.1
Whole body water mass	0.6	3.5	7.7	-1.4	-2.1	-1.9	0.3	2.8
Leg predicted mass (right)	0.8	4.5	7.0	-1.9	-2.3	-2.2	1.1	2.6
Arm fat mass (left)	0.8	3.4	5.9	-1.7	-1.8	-2.4	1.1	2.0
Number of self-reported non-cancer illnesses	0.1	0.2	0.6	-0.1	-0.8	0.0	0.2	0.7
Average weekly champagne plus white wine intake	0.8	1.2	1.9	1.3	0.5	1.4	-1.2	0.6
Miserableness	0.2	0.4	0.6	0.7	0.6	0.8	0.3	-0.7
Guilty feelings	1.7	2.5	3.3	-1.8	-1.8	-1.6	0.7	1.7
Wears glasses or contact lenses	0.5	0.6	1.9	-0.3	-1.4	0.5	-0.0	0.7
Ever taken oral contraceptive pill	0.5	0.5	1.3	0.6	0.8	1.2	-0.1	-0.5
Hearing aid user	0.5	0.6	0.7	0.8	0.8	-0.7	-0.7	-0.8
Mother’s age at death	0.8	1.0	2.5	-0.5	-0.3	-1.5	0.3	1.6
Financial situation satisfaction	3.4	4.2	7.5	2.5	2.5	0.8	-2.7	-0.6
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.1	0.1	0.7	-0.3	0.1	-1.0
Commuting to job workplace: Public transport	0.1	0.2	0.5	-0.2	-0.7	0.0	-0.4	0.3
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	-0.3	-0.1	-0.6	-0.1	0.6
Medication: Blood pressure	1.3	2.5	5.2	-1.1	-0.6	-2.2	0.8	2.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.4	-0.2	0.1	0.4	0.3	-0.7
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.2	0.5	0.8	-1.8	-0.6	1.4
High cholesterol (Self-reported)	0.3	0.5	1.3	1.2	0.6	0.8	-0.6	-0.1
Medication: Bendroflumethiazide	2.9	4.4	8.4	-1.9	-1.4	-2.0	2.0	2.9
Medication: Paracetamol	1.5	2.4	3.8	-1.6	-1.3	-1.9	1.3	1.4
Medication: Lisinopril	0.3	0.4	1.1	0.2	-0.5	-0.3	-0.8	1.0
Medication: Atorvastatin	1.1	1.3	3.2	-0.1	-0.9	-1.6	-0.5	1.8
Illnesses of father: High blood pressure	1.3	1.6	2.8	-1.2	-0.6	-1.6	1.7	1.1
Alcohol drinker status: Never	0.6	0.7	1.7	-1.0	-1.3	0.2	1.0	-0.2
Ever smoked	0.5	0.9	2.2	0.8	1.5	-0.3	0.5	-1.2
Basal metabolic rate	0.7	3.9	8.2	-1.4	-2.0	-2.2	0.4	2.9
Leg fat percentage (left)	0.1	0.5	2.3	0.1	0.2	-1.5	-0.3	0.6
Arm fat-free mass (left)	0.6	2.9	7.5	-0.9	-1.6	-1.9	0.0	2.7
Number of operations (self-reported)	0.4	0.6	1.2	-0.7	-0.7	-0.8	0.7	1.1
Average weekly beer plus cider intake	0.4	0.6	2.2	-0.5	0.4	-0.0	0.8	-1.5
Irritability	1.4	2.4	5.6	1.1	0.7	2.4	-1.5	-1.5
Risk taking	0.5	0.7	1.6	0.9	0.7	0.7	-0.6	-1.3
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.6	0.6	0.7	-0.6	-0.7	0.7
Fractured/broken bones in last 5 years	0.4	0.5	1.3	0.7	0.2	0.1	-1.1	0.7
Age started oral contraceptive pill	0.3	0.4	0.7	-0.7	-0.3	0.6	-0.7	0.8
Diastolic blood pressure, automated reading	4.1	12.6	29.3	-2.4	-1.2	-5.4	1.8	4.8
Ever depressed for a whole week	0.2	0.3	0.5	0.3	-0.6	0.7	-0.2	-0.7
Unable to work because of sickness or disability	1.5	2.0	5.7	0.8	1.5	1.2	0.0	-2.4
Commuting to job workplace: Cycle	0.9	1.1	3.5	0.9	1.9	0.2	-0.5	-0.8
Myopia	0.7	1.0	4.6	-0.1	-0.3	-0.2	0.0	2.1
Vascular/heart problems diagnosed by doctor	2.1	5.7	17.5	0.6	1.9	2.5	0.8	-4.2
Cholesterol lowering medication	0.2	0.3	1.2	-0.2	-1.1	0.4	0.1	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.4	1.0	0.9	-0.0	-1.6	0.0
Pain experienced in last month	0.4	0.7	1.4	-0.6	-1.2	-0.7	0.1	1.1
Supplements: Calcium	0.5	0.6	0.9	1.0	0.8	-0.5	-0.9	0.5
Basal cell carcinoma (self-reported)	0.3	0.3	0.8	-0.3	-0.5	-0.9	0.0	0.6
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.6	-0.9	-1.5	-0.4	0.1	1.6
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.1	-0.7	-1.0	-0.9	0.8	0.3
Heart disease (siblings)	1.4	1.7	4.0	-0.5	-0.5	-2.0	0.4	2.0
Alcohol drinker status: Previous	0.7	0.8	3.2	0.1	0.1	0.8	0.2	-1.8
Pack years of smoking	0.5	0.8	2.5	-0.1	-0.2	1.1	0.2	-1.6
Impedance of whole body	0.1	0.4	1.0	0.4	1.0	-0.7	0.0	0.7
Leg fat mass (left)	0.5	1.9	5.6	-0.7	-0.9	-2.4	0.4	1.5
Arm predicted mass (left)	0.6	3.1	8.1	-1.1	-1.5	-2.0	0.2	2.8