Hub : Genes

C1orf210

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Kidney Renal Clear Cell Carcinoma 0.0816 0.0280 5.2e-12 0.133 0.119 0.128 NA 0.126 1.0e-14 2.8e-13 2.9e-14 NA 5.0e-14
2 TCGA Kidney Renal Papillary Cell Carcinoma 0.1020 0.0480 3.8e-04 0.029 0.041 0.012 NA 0.014 8.1e-03 2.1e-03 6.8e-02 NA 4.9e-02
3 TCGA Prostate Adenocarcinoma 0.0345 0.0195 5.0e-03 0.006 0.005 0.010 NA 0.000 7.7e-02 7.9e-02 2.6e-02 NA 2.9e-01
4 TCGA Rectum Adenocarcinoma 0.1720 0.0870 9.2e-03 0.121 0.098 0.064 NA 0.094 9.4e-04 2.7e-03 1.3e-02 NA 3.3e-03
5 TCGA Thyroid Carcinoma 0.0420 0.0220 2.6e-03 0.021 0.013 0.012 NA 0.014 3.6e-03 1.6e-02 2.0e-02 NA 1.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.6 2.5 3.2 1.5 1.8 1.5 -1.3 -1.8
Bipolar Disorder or Schizophrenia 3.9 9.5 16.0 3.0 3.0 2.8 -2.3 -4.0
Depressed Affect (Nagel 2018) 0.2 0.4 0.8 0.9 0.4 0.7 -0.8 0.1
Depression (Nagel 2018) 0.7 1.1 1.3 1.1 0.9 1.1 -1.0 -1.0
Intelligence (Savage-Jansen 2018) 1.4 4.4 7.5 -1.7 -1.4 -2.3 2.1 2.7
Neuroticism (Nagel 2018) 0.4 0.9 3.0 -0.3 -0.0 -1.3 0.1 1.7
Schizophrenia (2018) 3.5 7.3 13.9 2.7 2.4 2.5 -2.0 -3.7
Schizophrenia vs Biploar Disorder 0.9 1.2 2.5 -1.6 -0.4 -0.4 1.6 -0.8
Worry (Nagel 2018) 0.7 1.4 3.5 -0.3 -0.0 -1.8 0.7 1.9
Alzheimer’s Disease (in mother) 0.2 0.2 0.8 0.2 -0.1 0.2 -0.5 -0.9
Alzheimer’s Disease (in father) 0.4 0.5 1.0 1.0 0.5 0.5 -0.9 0.1
Alzheimer’s Disease (including proxy) 0.5 0.7 0.9 0.9 0.6 0.9 -0.8 -0.9
Crohns Disease (2017) 0.4 0.9 1.7 -0.5 1.3 -0.8 0.9 -1.1
Irritable Bowel Disease (IBD) 0.5 1.3 3.1 -0.4 1.6 -0.3 0.7 -1.8
Ulcerative Colitis (UC) 0.5 0.9 2.9 -0.6 0.8 0.2 0.7 -1.7
Major Depression (MDD) 2.2 2.7 4.7 1.5 1.6 2.2 -0.2 -2.0
Reaction Time 0.9 1.7 5.1 0.0 -0.9 -1.3 -0.9 2.2
Verbal and Numeric Reasoning (VNR) 1.5 3.5 5.8 -1.7 -1.8 -1.7 1.6 2.4
Breast Cancer 0.4 0.9 2.9 -0.2 -0.2 1.7 -0.2 -1.2
Ovarian Cancer 0.4 0.5 1.9 0.2 -0.1 -1.4 -0.5 0.6
Prostate Cancer 0.3 0.4 1.2 -0.2 -0.2 1.0 -0.1 -1.1
Age at First Birth 1.1 1.6 3.1 -1.2 -1.6 -0.3 0.7 1.8
Bipolar Disorder (2011) 1.6 1.5 2.5 1.6 1.2 0.0 -1.3 -1.3
Body Mass Index (BMI) (2010) 0.7 0.9 1.6 1.1 1.3 -0.2 -1.3 0.0
Coronary Artery Disease (CAD) 1.2 1.4 6.4 -0.6 0.0 0.0 0.7 2.5
Crohns Disease (2012) 0.7 1.2 2.9 0.4 1.6 0.0 0.4 -1.7
Mean Putamen Volume 0.3 0.4 1.4 -0.7 0.1 -0.0 1.2 -0.4
Fasting Glucose 0.9 1.1 2.6 -1.5 -0.6 -0.5 1.6 -0.0
HbA1C 0.1 0.1 0.2 -0.2 0.0 0.3 0.2 0.4
HDL Cholesterol 0.6 1.0 2.1 0.7 0.6 1.4 -0.4 -1.4
LDL Cholesterol 0.7 1.1 2.0 -1.2 -1.1 0.4 1.4 -0.6
Lupus 0.4 0.7 2.9 -0.6 -0.2 0.0 1.7 0.1
Neuroticism (2016) 2.3 3.3 4.4 2.1 1.5 -1.6 -1.9 2.0
Primary Biliary Cirrhosis 0.4 0.6 1.3 -0.6 -1.1 0.1 0.3 1.0
Rheumatoid Arthritis 0.4 0.5 1.7 -0.2 1.0 -1.3 0.0 0.0
Schizophrenia (2014) 1.9 4.2 9.5 1.6 1.6 2.2 -1.3 -3.1
Triglycerides 0.2 0.3 0.7 -0.8 -0.7 0.4 0.5 0.1
Type 2 Diabetes (T2D) (2012) 0.3 0.4 0.9 -0.8 -0.1 0.4 0.9 -0.3
Ulcerative Colitis 1.2 1.8 5.9 0.2 1.2 0.9 0.8 -2.4
Blood Eosinophil Count 0.1 0.9 1.6 0.2 -0.9 -1.2 -0.7 1.3
Blood Platelet Count 0.7 7.9 15.8 2.4 3.3 -4.0 -2.2 1.5
Blood Red Count 2.4 22.9 61.2 -1.5 -2.4 -6.7 -0.3 7.8
Blood White Count 1.3 9.7 26.0 0.7 -0.1 -4.5 -1.3 5.1
Heel T-Score 0.1 0.4 1.2 -0.6 0.2 0.4 0.5 -1.1
BMI 0.4 2.4 4.2 -1.0 -1.7 -1.9 0.3 2.1
Height 0.7 12.8 40.8 -2.1 -3.5 -2.4 0.4 6.4
Waist Hip Ratio (WHR) 0.2 0.8 1.6 -0.7 -0.2 -1.3 0.9 1.1
Systolic Blood Pressure 4.5 22.5 62.7 -1.2 -2.0 -6.6 -0.6 7.9
Smoking Status 0.7 1.6 5.6 0.1 0.6 1.2 0.9 -2.4
Allergy or Eczema 0.2 0.5 1.7 0.5 1.3 -0.1 -0.2 -0.5
Cardiovascular Disease 1.9 6.1 17.8 -1.3 -2.4 -2.4 -0.2 4.2
Hypothyroidism (self reported) 0.9 2.2 3.7 -0.8 -1.9 -1.7 -0.1 1.9
Respiratory disease 0.9 2.1 3.1 1.1 1.7 -1.6 -1.1 1.5
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.0 1.0 0.8 1.4 -0.8 -1.2
Lung FEV1/FVC ratio 0.1 0.6 1.1 0.7 0.6 -0.8 -0.7 1.0
Lung FVC 0.1 0.3 0.6 -0.6 -0.1 -0.3 0.6 -0.8
Neuroticism 0.3 0.6 2.3 0.4 0.2 -0.7 -0.3 1.5
Chronotype (morning person) 1.5 3.4 4.9 -2.2 -2.2 -1.2 1.9 1.5
Hair Pigment 0.0 0.2 0.6 0.5 0.7 -0.4 -0.2 -0.5
Tanning 0.0 0.5 1.1 0.3 1.0 -1.0 0.2 -0.8
Hand grip strength (left) 0.3 0.8 1.6 -0.8 -1.2 -0.6 0.0 1.3
Number of treatments/medications taken 0.5 0.9 2.8 0.5 -0.2 -0.9 -0.6 1.7
Average weekly spirits intake 0.7 0.8 1.6 -0.4 1.0 -0.8 0.9 -1.3
Sensitivity / hurt feelings 0.7 1.2 2.0 0.9 0.7 -0.9 -1.4 1.4
Frequency of depressed mood in last 2 weeks 1.9 2.7 4.8 2.1 1.4 1.0 -2.2 -1.1
Hearing difficulty/problems: Yes 1.0 1.6 6.2 -0.1 0.2 1.3 0.2 -2.5
Relative age of first facial hair 1.3 2.7 7.5 0.7 0.4 2.2 -0.9 -2.7
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 1.4 -1.2 -1.2 0.1 0.9 -0.2
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.5 -0.3 -0.7 -1.3 -0.4 1.6
Ever had hysterectomy (womb removed) 0.1 0.1 0.2 0.4 0.4 -0.1 -0.3 0.4
Systolic blood pressure, automated reading 3.8 11.0 25.5 -1.6 -1.6 -4.9 0.3 5.0
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.0 0.1 0.5 1.0 -0.6 -0.7
Angina 3.0 4.0 9.8 -0.4 -1.0 -3.1 -0.5 3.0
Medication for hormone replacement therapy 0.4 0.4 1.0 0.8 1.0 0.1 -0.5 -0.6
Vitamin and mineral supplements 0.7 0.9 1.9 -0.7 -0.4 0.8 1.2 -1.4
Supplements: Zinc 3.3 3.6 5.7 2.4 2.1 1.5 -2.1 -0.9
Medication: Co-codamol 1.4 1.7 2.7 -1.4 -0.7 -1.4 1.1 1.6
Medication: Metformin 1.8 2.6 3.5 1.9 1.6 1.4 -1.3 -1.8
Diabetes (father) 0.7 0.9 1.5 0.9 0.4 -1.0 -1.2 0.9
Diabetes (mother) 0.2 0.3 0.9 0.6 0.1 0.1 -1.0 0.0
Severe depression (siblings) 0.4 0.5 0.9 0.6 -0.4 0.6 -0.7 0.9
Pack years adult smoking proportion 0.7 1.1 3.1 0.3 -0.0 1.4 -0.2 -1.8
Impedance of leg (right) 0.4 2.0 4.6 1.8 2.1 -0.3 -1.4 0.3
Leg fat-free mass (left) 0.9 4.9 8.0 -2.0 -2.4 -2.4 1.1 2.8
Trunk fat percentage 0.6 2.3 5.0 -1.5 -1.0 -2.2 1.5 1.1
Hand grip strength (right) 0.7 2.0 4.0 -1.0 -1.5 -1.6 0.2 2.0
Townsend deprivation index at recruitment 1.3 1.9 4.5 1.0 1.1 1.5 -0.6 -2.1
Current tobacco smoking 2.2 3.6 6.0 1.9 1.8 1.9 -1.3 -2.5
Average weekly fortified wine intake 0.9 1.0 2.3 -1.5 -0.3 -0.8 1.4 -0.1
Maternal smoking around birth 2.7 4.0 12.5 -1.1 -0.7 2.1 0.9 -3.5
Fed-up feelings 0.6 1.0 2.0 1.4 0.8 0.3 -1.3 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 2.5 0.7 0.5 0.8 -1.0 -1.6
Relative age voice broke 0.7 1.1 2.5 1.0 1.2 0.5 -0.7 -1.6
Taking other prescription medications 0.1 0.1 0.4 0.6 0.1 0.2 -0.2 0.2
Age when periods started (menarche) 3.5 8.5 13.9 2.4 2.5 3.4 -2.3 -3.7
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.6 0.4 0.7 -0.1 -0.8 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.7 0.5 -0.1 0.0 -0.8 0.6
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.3 1.0 1.2 0.1 -0.6 -0.3
Qualifications: CSEs or equivalent 0.4 0.5 1.1 -1.0 -0.6 0.1 0.1 -1.0
Serious illness, injury or assault to yourself 0.9 1.1 1.7 1.0 0.6 1.3 -1.2 -1.0
High blood pressure 1.7 4.6 13.2 -0.9 -1.9 -2.3 -0.3 3.6
Hayfever, allergic rhinitis or eczema 0.4 0.9 2.6 0.9 1.6 0.1 -0.5 -0.9
Multivitamins +/- minerals 0.1 0.2 0.5 0.0 0.7 -0.6 0.0 -0.1
Stomach or abdominal pain in last month 1.8 2.2 4.7 2.2 1.7 0.7 -1.7 -0.6
Supplements: Glucosamine 0.8 1.0 2.9 1.1 0.9 0.3 -1.7 -0.3
Diverticular disease/diverticulitis (self-reported) 1.1 1.4 4.0 1.3 2.0 0.3 -0.5 -0.9
Medication: Atenolol 0.7 0.9 1.3 1.0 0.9 -0.6 -1.0 1.1
Medication: Levothyroxine sodium 3.0 5.1 11.3 -2.6 -3.4 -1.6 1.3 1.9
Sitting height 0.6 4.2 14.7 -0.8 -1.1 -2.1 -0.0 3.8
Chronic bronchitis/emphysema (father) 0.6 0.7 1.7 0.7 -0.7 1.3 -0.8 -0.6
High blood pressure (mother) 1.6 2.2 8.5 0.2 -0.2 -1.6 -0.1 2.9
Body mass index (BMI) 0.2 0.8 1.6 -0.9 -1.0 -1.3 0.7 0.4
Impedance of leg (left) 0.4 2.1 4.7 1.8 2.2 -0.2 -1.5 0.3
Leg predicted mass (left) 0.9 4.8 7.8 -1.9 -2.3 -2.4 1.1 2.8
Trunk fat mass 0.7 3.1 5.6 -1.7 -1.6 -2.4 1.3 1.7
Waist circumference 0.5 1.7 3.2 -1.2 -1.2 -1.8 0.9 1.3
Number of incorrect matches in round 0.3 0.5 1.4 -0.1 0.3 1.2 0.0 -1.0
Past tobacco smoking 0.2 0.4 0.6 -0.4 -0.7 0.7 -0.6 0.7
Alcohol usually taken with meals 3.1 5.0 16.9 -0.1 -1.4 -2.3 -0.9 4.1
Nervous feelings 0.4 0.7 1.9 0.3 0.6 -1.4 -0.2 1.0
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.1 4.1 1.5 1.8 0.1 -2.0 -0.8
Hearing difficulty/problems with background noise 0.4 0.6 1.7 0.9 1.3 0.0 -0.5 -0.4
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 0.4 -0.2 0.1 -0.4 -0.3
Had menopause 1.8 2.2 4.2 -1.2 -1.1 -2.1 0.9 1.9
Had other major operations 0.3 0.4 1.6 0.5 -0.1 0.1 -0.0 1.2
Forced vital capacity (FVC) 0.7 2.8 6.0 -1.2 -1.1 -2.3 0.7 2.4
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.3 0.4 0.4 -0.0 -0.5 0.6
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 2.2 0.5 -0.1 1.0 -0.8 -1.5
Qualifications: None of the above 2.0 4.2 13.2 1.3 2.2 1.0 -0.2 -3.6
Financial difficulties in last 2 years 0.7 0.9 2.2 1.1 0.5 0.5 -1.5 -0.7
Mouth/teeth dental problems 1.0 1.6 3.8 -0.8 0.1 -1.9 1.0 1.6
Heart attack 1.0 1.3 2.7 -1.0 -1.6 -0.5 0.3 1.5
Allergy 0.6 1.3 3.3 -1.4 -1.8 0.4 1.0 0.3
Pain all over the body in last month 0.5 0.6 0.9 0.9 0.8 0.4 -0.6 -0.9
Diabetes (self-reported) 1.3 1.9 4.0 1.0 1.0 1.8 -0.8 -2.0
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.3 -0.8 -0.2 0.9 1.5 -1.5
Medication: Ramipril 1.0 1.3 3.9 -0.5 -1.4 -0.6 -0.1 2.0
Medication: Simvastatin 0.5 0.8 2.0 -0.4 -0.6 1.4 0.6 -1.0
Fluid intelligence score 1.2 2.6 4.9 -1.6 -1.5 -0.9 1.5 2.2
Illnesses of siblings 0.2 0.2 0.4 -0.1 0.5 0.5 0.6 -0.6
Neuroticism score 0.2 0.5 1.2 0.8 0.4 -0.3 -1.1 0.7
Weight 0.8 3.8 7.4 -1.3 -1.8 -2.5 0.4 2.7
Impedance of arm (right) 0.1 0.6 1.2 -0.8 -0.2 -1.1 0.8 0.9
Arm fat percentage (right) 0.5 1.9 3.3 -1.5 -1.4 -1.8 1.2 0.9
Trunk fat-free mass 0.5 2.8 7.7 -0.9 -1.9 -1.3 -0.3 2.8
Hip circumference 0.7 2.8 5.5 -1.1 -1.5 -2.3 0.5 2.3
Time employed in main current job 1.5 1.7 4.6 -0.8 -0.6 -2.1 0.2 1.7
Alcohol intake versus 10 years previously 0.2 0.3 1.1 0.1 -0.0 0.2 -0.4 -1.0
Father’s age at death 1.0 1.4 2.2 0.9 1.1 1.5 -0.8 -1.4
Worrier / anxious feelings 0.9 1.7 4.5 -0.9 -0.5 -1.6 0.9 2.1
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 1.4 -0.6 -0.4 -0.2 1.2 -0.4
Falls in the last year 0.6 0.8 1.2 0.9 1.1 0.4 -1.1 -0.7
Hair/balding pattern: Pattern 3 0.2 0.3 0.6 -0.5 -0.4 -0.6 -0.2 0.8
Number of live births 0.3 0.5 1.3 0.6 1.1 -0.7 -0.2 -0.4
Forced expiratory volume in 1-second (FEV1) 0.9 3.1 7.0 -1.0 -0.6 -2.6 0.6 2.6
Pulse rate 0.1 0.2 0.3 -0.6 -0.5 -0.2 0.4 0.1
Happiness 2.8 3.4 5.9 2.2 1.6 1.4 -2.4 -1.2
Noisy workplace 4.2 5.2 10.3 1.5 0.9 3.2 -1.7 -3.1
Qualifications: A levels/AS levels or equivalent 1.6 3.4 11.8 -1.0 -1.6 -1.2 0.7 3.4
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.3 -0.2 -0.1 0.4 0.6 -0.1
Mouth/teeth dental problems: Dentures 0.2 0.3 1.0 -0.4 -0.6 -0.3 -0.2 -1.0
Asthma 0.3 0.6 1.2 0.7 1.1 -0.9 -0.2 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.9 -0.0 0.2 -1.0 -0.1 0.3
Medication: Cholesterol lowering 0.4 0.7 2.6 0.6 -0.1 1.6 -0.5 -0.4
Depression (self-reported) 1.0 1.2 2.8 0.4 0.5 1.7 -0.1 -1.6
Medication: Lansoprazole 2.3 2.7 8.5 0.8 -0.4 2.9 -1.2 -1.6
Prospective memory result 0.1 0.2 0.5 0.7 0.5 0.2 -0.4 -0.1
Lung cancer (father) 1.0 1.2 2.8 0.5 -0.1 1.7 -0.6 -1.6
Illnesses of mother 1.2 1.5 2.6 0.8 1.3 1.2 -1.1 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 5.1 -0.5 -0.7 -1.8 0.2 2.3
Pulse wave Arterial Stiffness index 2.1 2.4 5.5 -2.1 -2.3 -0.4 1.2 0.6
Impedance of arm (left) 0.1 0.7 1.0 -0.8 -0.2 -1.0 0.9 0.8
Arm fat mass (right) 0.7 2.9 4.9 -1.6 -1.7 -2.2 1.0 1.7
Trunk predicted mass 0.5 2.9 8.1 -0.9 -1.9 -1.3 -0.3 2.8
Standing height 0.8 7.7 26.3 -1.0 -1.9 -2.6 -0.6 5.1
Length of working week for main job 1.8 2.0 3.5 -1.9 -1.2 -1.6 1.4 0.6
Exposure to tobacco smoke at home 1.4 1.5 2.9 1.2 -0.2 1.7 -1.6 -0.8
Breastfed as a baby 0.7 0.9 2.5 -0.1 1.6 0.2 0.9 -1.0
Tense / ‘highly strung’ 0.1 0.1 0.3 -0.2 -0.3 -0.5 0.2 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 3.3 -0.3 -0.2 1.8 1.0 -1.7
Hair/balding pattern: Pattern 4 0.6 1.4 4.0 -0.7 -0.7 -1.2 0.6 2.0
Birth weight of first child 0.1 0.1 0.5 -0.4 -0.0 -0.0 0.2 -0.7
Peak expiratory flow (PEF) 1.6 3.8 9.5 -0.9 -0.5 -2.7 0.8 3.1
Pulse wave reflection index 3.1 3.8 5.4 -2.3 -2.3 -1.8 1.4 1.7
Ever highly irritable/argumentative for 2 days 1.3 1.6 3.4 -1.4 -0.2 -0.3 1.9 -1.6
Loud music exposure frequency 0.5 0.6 2.0 0.9 0.3 -0.0 -1.4 0.2
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.6 0.5 0.1 0.7 -0.2 0.7
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.9 -0.2 -0.2 0.9 0.7 -0.7
Blood clot in the leg (DVT) 0.5 0.6 1.1 -0.6 -1.0 -1.1 0.8 0.4
Medication: Paracetamol 1.7 2.8 3.6 -1.9 -1.7 -1.8 1.6 1.4
Headache pain in last month 1.2 2.0 4.5 -2.0 -1.1 -0.5 2.1 0.6
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 2.9 -0.3 1.0 -1.7 0.5 -0.7
Glaucoma (self-reported) 0.2 0.3 0.7 -0.2 -0.3 -0.5 -0.5 0.8
Gout (self-reported) 0.4 0.5 1.2 0.9 -0.0 -0.1 -1.1 0.6
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 6.2 -1.4 -2.5 -0.9 0.6 1.4
Medication: Amlodipine 2.5 3.5 6.0 -2.5 -2.4 -0.1 2.2 0.8
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.1 1.1 0.8 0.7 -0.8 -0.2
Birth weight 1.7 3.8 5.7 1.7 2.0 2.3 -1.1 -2.4
Chronic bronchitis/emphysema (mother) 3.3 3.9 14.1 -0.4 0.3 2.0 1.0 -3.8
High blood pressure (siblings) 0.2 0.4 0.9 0.6 -0.3 -0.1 -0.6 1.0
Forced vital capacity (FVC), Best measure 0.4 1.4 4.1 -0.7 -1.0 -1.3 0.2 2.0
Body fat percentage 0.3 1.2 3.5 -0.9 -0.6 -1.9 1.0 0.7
Leg fat percentage (right) 0.2 0.6 2.6 0.2 0.3 -1.6 -0.2 0.6
Arm fat-free mass (right) 0.5 2.7 7.7 -0.6 -1.2 -2.0 -0.2 2.8
Exposure to tobacco smoke outside home 0.3 0.4 0.9 -0.6 0.1 -0.3 0.9 -1.0
Comparative body size at age 10 1.7 4.6 13.1 0.8 0.9 2.9 -0.1 -3.6
Number of full brothers 0.9 1.2 2.2 1.5 1.1 0.4 -1.4 -0.6
Worry too long after embarrassment 2.3 3.8 5.3 -2.3 -1.9 -2.1 1.3 2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 3.4 0.2 -0.5 1.9 -0.0 -0.8
Wheeze or whistling in the chest in last year 0.2 0.4 1.0 0.2 -0.1 -0.7 -0.5 1.0
Number of children fathered 0.2 0.2 0.4 -0.3 -0.5 -0.7 0.3 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.3 -0.6 0.2 -0.5 0.5 0.2
Age at first live birth 0.2 0.4 1.6 -0.0 -0.4 -0.2 -0.3 1.3
Pulse wave peak to peak time 1.9 2.3 5.3 2.1 2.3 0.1 -1.3 -0.2
Health satisfaction 3.8 5.0 8.8 3.0 2.8 0.5 -2.6 -1.1
Shortness of breath walking on level ground 0.2 0.3 0.7 -0.5 0.2 -0.8 0.6 -0.0
Qualifications: College or University degree 2.2 6.9 21.6 -1.8 -2.8 -1.2 0.2 4.7
Eye problems/disorders: None of the above 0.1 0.2 0.4 0.6 0.0 0.1 0.1 0.7
Mouth/teeth dental problems: Loose teeth 1.5 1.8 4.3 1.7 0.4 1.2 -2.1 0.0
Emphysema/chronic bronchitis 0.5 0.6 1.3 1.0 1.1 0.1 -0.9 0.0
Medication for pain relief, constipation, heartburn 0.7 1.2 3.2 0.0 0.7 1.5 0.3 -1.8
Neck or shoulder pain in last month 0.6 0.8 1.9 0.9 0.3 0.9 -1.4 -0.7
Medication: Blood pressure 0.6 1.1 3.3 -0.6 -1.8 0.7 0.1 1.2
Angina (self-reported) 3.0 3.9 9.1 -0.8 -1.3 -3.0 -0.2 2.9
Migraine (self-reported) 0.7 0.9 3.3 -1.0 -0.3 0.1 1.8 -0.4
Medication: Ibuprofen 0.5 0.6 1.6 -0.1 -0.2 -1.3 -0.4 1.1
Medication: Allopurinol 1.7 2.3 4.3 2.0 1.6 0.3 -2.1 0.1
Medication: Omeprazole 2.0 2.4 5.1 1.8 1.9 -0.2 -2.2 -0.3
Medication: Seretide 50 evohaler 0.8 0.9 2.2 1.4 0.4 0.2 -1.5 0.5
Mean time to correctly identify matches 0.9 1.7 4.5 0.1 -0.4 -1.6 -1.1 2.1
Heart disease (mother) 6.3 7.7 10.8 -2.9 -3.3 -1.9 2.5 3.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 2.7 -0.9 0.1 -1.0 1.6 0.2
Whole body fat mass 0.6 2.4 5.3 -1.2 -1.3 -2.3 0.9 1.7
Leg fat mass (right) 0.4 1.7 5.3 -0.7 -0.9 -2.3 0.4 1.4
Arm predicted mass (right) 0.5 2.5 6.7 -0.9 -1.4 -1.8 -0.0 2.6
Pulse rate, automated reading 1.5 4.7 8.7 -1.8 -1.7 -2.5 1.5 3.0
Alcohol intake frequency. 0.6 1.5 6.1 -0.1 0.8 0.3 0.7 -2.5
Comparative height size at age 10 1.6 8.8 27.8 -1.8 -2.6 -2.5 0.5 5.3
Number of full sisters 0.4 0.5 1.2 -0.9 -0.6 -0.1 1.1 -0.2
Suffer from ‘nerves’ 0.2 0.3 1.0 -0.0 0.7 -1.0 0.4 0.2
Overall health rating 1.0 2.2 3.6 1.9 1.2 1.1 -1.5 -1.5
Chest pain or discomfort 0.2 0.4 0.8 0.7 0.2 0.9 -0.7 -0.2
Had major operations 0.1 0.1 0.2 0.3 -0.0 -0.1 -0.5 -0.0
Age at last live birth 0.5 0.8 2.2 -0.0 -0.4 -1.0 -0.7 1.5
Family relationship satisfaction 1.2 1.5 2.7 1.6 0.6 1.3 -1.4 -1.0
Leg pain on walking 0.1 0.2 0.5 0.1 0.7 -0.6 -0.1 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.9 0.7 0.1 -0.1 -1.0 -0.1
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.2 -0.1 -0.1 -0.1 0.4 -0.1
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 2.0 -0.4 -0.2 -1.2 0.4 1.4
Medication: Aspirin 1.3 1.7 3.4 1.7 0.6 -0.4 -1.9 1.2
Supplements: Vitamin C 1.9 2.2 6.4 1.7 0.5 0.1 -2.5 1.3
Knee pain experienced in last month 0.3 0.5 1.3 -0.3 -0.6 -1.1 0.5 0.7
Hypertension (Self-reported) 1.1 3.1 9.0 -0.8 -1.5 -1.9 -0.2 3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.4 2.8 4.8 2.2 1.6 1.4 -1.4 -1.7
Illnesses of father: Heart disease 2.3 3.2 10.3 -0.8 -0.8 -2.1 -0.1 3.2
Illnesses of siblings: Diabetes 0.5 0.6 2.4 0.2 0.4 0.6 0.1 -1.5
Smoking status: Previous 0.1 0.2 0.8 -0.1 0.0 -0.3 0.9 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.0 5.8 0.4 -0.6 -1.0 -1.7 2.4
Whole body fat-free mass 0.6 3.5 7.7 -1.4 -2.1 -1.8 0.3 2.8
Leg fat-free mass (right) 0.8 4.2 7.0 -1.9 -2.2 -2.2 1.0 2.6
Arm fat percentage (left) 0.6 2.3 4.4 -1.5 -1.5 -2.1 1.2 1.2
Average weekly red wine intake 2.1 3.1 7.8 -1.3 -0.8 -2.8 1.3 1.9
Handedness (chirality/laterality): Left-handed 1.9 2.3 3.1 1.5 1.2 1.8 -1.6 -1.5
Mood swings 1.8 3.3 6.3 2.5 1.7 1.0 -2.5 -0.6
Loneliness, isolation 0.8 1.1 2.9 1.3 1.0 -0.1 -1.7 -0.2
Long-standing illness, disability or infirmity 0.2 0.3 0.6 0.3 -0.6 -0.2 -0.6 0.8
Ever had bowel cancer screening 0.3 0.3 0.6 -0.8 -0.7 0.3 0.7 -0.1
Diabetes diagnosed by doctor 0.6 0.9 1.9 0.6 0.7 1.4 -0.6 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.4 -1.2 -0.7 -0.9 1.1 0.1
Friendships satisfaction 2.3 2.9 4.9 1.5 0.7 2.2 -1.7 -1.9
Qualifications: nursing, teaching 0.2 0.3 0.9 0.1 0.0 0.8 0.3 0.9
Commuting to job workplace: Walk 0.5 0.5 0.9 0.8 0.3 1.0 -1.0 -0.2
Eye problems/disorders: Cataract 1.1 1.3 2.4 1.1 1.4 -0.4 -1.6 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 4.4 -0.6 -0.8 2.1 0.4 -1.1
Medication for cholesterol 0.6 0.9 2.6 0.3 0.2 1.6 -0.1 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.0 0.1 0.1 -0.4 -0.1 -0.0 0.1
Back pain experienced in last month 0.2 0.3 0.5 0.3 0.2 0.5 -0.6 -0.7
Mineral and other dietary supplements 1.1 1.4 2.1 -1.0 -1.4 1.5 1.1 -0.9
Breast cancer (self-reported) 1.1 1.3 2.6 -1.6 -1.1 0.0 1.5 0.4
Asthma (self-reported) 0.4 0.8 1.6 1.0 1.3 -0.8 -0.3 0.8
Osteoporosis (self-reported) 0.1 0.2 0.6 0.8 0.4 0.1 -0.1 -0.1
Osteoarthritis (self-reported) 0.7 1.0 2.0 1.4 0.4 0.6 -1.4 0.5
Medication: Aspirin 0.9 1.2 2.2 1.5 0.4 -0.3 -1.5 1.1
Medication: Gliclazide 0.8 1.0 1.6 1.3 0.9 1.0 -1.0 -0.7
Illnesses of father: None of the above (group 1) 1.2 1.5 3.8 0.5 0.4 1.8 -0.2 -1.9
Smoking status: Current 1.8 2.8 4.7 1.7 1.7 1.4 -1.3 -2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.8 -0.1 0.7 -0.9 0.9 0.1
Whole body water mass 0.6 3.5 7.7 -1.4 -2.1 -1.9 0.3 2.8
Leg predicted mass (right) 0.8 4.5 7.0 -1.9 -2.3 -2.2 1.1 2.6
Arm fat mass (left) 0.8 3.4 5.9 -1.7 -1.8 -2.4 1.1 2.0
Number of self-reported non-cancer illnesses 0.1 0.2 0.6 -0.1 -0.8 0.0 0.2 0.7
Average weekly champagne plus white wine intake 0.8 1.2 1.9 1.3 0.5 1.4 -1.2 0.6
Miserableness 0.2 0.4 0.6 0.7 0.6 0.8 0.3 -0.7
Guilty feelings 1.7 2.5 3.3 -1.8 -1.8 -1.6 0.7 1.7
Wears glasses or contact lenses 0.5 0.6 1.9 -0.3 -1.4 0.5 -0.0 0.7
Ever taken oral contraceptive pill 0.5 0.5 1.3 0.6 0.8 1.2 -0.1 -0.5
Hearing aid user 0.5 0.6 0.7 0.8 0.8 -0.7 -0.7 -0.8
Mother’s age at death 0.8 1.0 2.5 -0.5 -0.3 -1.5 0.3 1.6
Financial situation satisfaction 3.4 4.2 7.5 2.5 2.5 0.8 -2.7 -0.6
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.1 0.1 0.7 -0.3 0.1 -1.0
Commuting to job workplace: Public transport 0.1 0.2 0.5 -0.2 -0.7 0.0 -0.4 0.3
Eye problems/disorders: Glaucoma 0.1 0.2 0.3 -0.3 -0.1 -0.6 -0.1 0.6
Medication: Blood pressure 1.3 2.5 5.2 -1.1 -0.6 -2.2 0.8 2.3
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.4 -0.2 0.1 0.4 0.3 -0.7
Supplements: Fish oil (including cod liver oil) 1.0 1.3 3.2 0.5 0.8 -1.8 -0.6 1.4
High cholesterol (Self-reported) 0.3 0.5 1.3 1.2 0.6 0.8 -0.6 -0.1
Medication: Bendroflumethiazide 2.9 4.4 8.4 -1.9 -1.4 -2.0 2.0 2.9
Medication: Paracetamol 1.5 2.4 3.8 -1.6 -1.3 -1.9 1.3 1.4
Medication: Lisinopril 0.3 0.4 1.1 0.2 -0.5 -0.3 -0.8 1.0
Medication: Atorvastatin 1.1 1.3 3.2 -0.1 -0.9 -1.6 -0.5 1.8
Illnesses of father: High blood pressure 1.3 1.6 2.8 -1.2 -0.6 -1.6 1.7 1.1
Alcohol drinker status: Never 0.6 0.7 1.7 -1.0 -1.3 0.2 1.0 -0.2
Ever smoked 0.5 0.9 2.2 0.8 1.5 -0.3 0.5 -1.2
Basal metabolic rate 0.7 3.9 8.2 -1.4 -2.0 -2.2 0.4 2.9
Leg fat percentage (left) 0.1 0.5 2.3 0.1 0.2 -1.5 -0.3 0.6
Arm fat-free mass (left) 0.6 2.9 7.5 -0.9 -1.6 -1.9 0.0 2.7
Number of operations (self-reported) 0.4 0.6 1.2 -0.7 -0.7 -0.8 0.7 1.1
Average weekly beer plus cider intake 0.4 0.6 2.2 -0.5 0.4 -0.0 0.8 -1.5
Irritability 1.4 2.4 5.6 1.1 0.7 2.4 -1.5 -1.5
Risk taking 0.5 0.7 1.6 0.9 0.7 0.7 -0.6 -1.3
Ever had prostate specific antigen (PSA) test 0.4 0.4 0.6 0.6 0.7 -0.6 -0.7 0.7
Fractured/broken bones in last 5 years 0.4 0.5 1.3 0.7 0.2 0.1 -1.1 0.7
Age started oral contraceptive pill 0.3 0.4 0.7 -0.7 -0.3 0.6 -0.7 0.8
Diastolic blood pressure, automated reading 4.1 12.6 29.3 -2.4 -1.2 -5.4 1.8 4.8
Ever depressed for a whole week 0.2 0.3 0.5 0.3 -0.6 0.7 -0.2 -0.7
Unable to work because of sickness or disability 1.5 2.0 5.7 0.8 1.5 1.2 0.0 -2.4
Commuting to job workplace: Cycle 0.9 1.1 3.5 0.9 1.9 0.2 -0.5 -0.8
Myopia 0.7 1.0 4.6 -0.1 -0.3 -0.2 0.0 2.1
Vascular/heart problems diagnosed by doctor 2.1 5.7 17.5 0.6 1.9 2.5 0.8 -4.2
Cholesterol lowering medication 0.2 0.3 1.2 -0.2 -1.1 0.4 0.1 -0.2
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 2.4 1.0 0.9 -0.0 -1.6 0.0
Pain experienced in last month 0.4 0.7 1.4 -0.6 -1.2 -0.7 0.1 1.1
Supplements: Calcium 0.5 0.6 0.9 1.0 0.8 -0.5 -0.9 0.5
Basal cell carcinoma (self-reported) 0.3 0.3 0.8 -0.3 -0.5 -0.9 0.0 0.6
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.6 -0.9 -1.5 -0.4 0.1 1.6
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.1 -0.7 -1.0 -0.9 0.8 0.3
Heart disease (siblings) 1.4 1.7 4.0 -0.5 -0.5 -2.0 0.4 2.0
Alcohol drinker status: Previous 0.7 0.8 3.2 0.1 0.1 0.8 0.2 -1.8
Pack years of smoking 0.5 0.8 2.5 -0.1 -0.2 1.1 0.2 -1.6
Impedance of whole body 0.1 0.4 1.0 0.4 1.0 -0.7 0.0 0.7
Leg fat mass (left) 0.5 1.9 5.6 -0.7 -0.9 -2.4 0.4 1.5
Arm predicted mass (left) 0.6 3.1 8.1 -1.1 -1.5 -2.0 0.2 2.8