TWAS hub - TMEM125

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0224	0.0117	1.4e-02	0.009	0.008	0.007	0.005	0.013	2.1e-02	3.2e-02	3.8e-02	0.059	7.4e-03
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0747	0.0234	7.1e-12	0.119	0.116	0.127	NA	0.120	2.7e-13	6.3e-13	4.4e-14	NA	2.0e-13
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1310	0.0490	9.9e-06	0.039	0.061	0.062	NA	0.066	2.7e-03	2.1e-04	2.0e-04	NA	1.2e-04
4	TCGA	Prostate Adenocarcinoma	0.1440	0.0629	9.8e-04	0.002	0.035	0.028	NA	0.002	2.0e-01	1.2e-04	5.4e-04	NA	1.7e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Alcohol usually taken with meals	5.8	9.4	20.5	-4.5	0.9	1.0	-3.9
Maternal smoking around birth	5.1	7.4	26.1	5.1	-1.4	-1.0	0.6
Age when periods started (menarche)	5.0	12.1	27.3	5.2	1.7	2.5	3.5
Heart disease (mother)	5.0	6.1	10.5	-2.5	-2.5	-3.2	-1.1
Medication: Bendroflumethiazide	3.9	5.9	14.7	-3.8	-1.6	-2.1	-1.4
Schizophrenia (2018)	3.8	7.8	18.1	4.3	1.8	1.8	2.6
Bipolar Disorder or Schizophrenia	3.7	8.9	19.5	4.4	2.1	2.5	2.3
Health satisfaction	3.6	4.7	8.8	1.1	2.9	3.0	-0.8
Diastolic blood pressure, automated reading	3.5	10.8	25.5	-5.0	-1.5	-1.4	-3.6
Townsend deprivation index at recruitment	3.2	4.6	10.4	2.6	0.6	0.8	3.2
Financial situation satisfaction	3.2	4.0	8.5	1.1	2.5	2.9	0.0
Qualifications: None of the above	3.0	6.3	22.8	4.8	0.5	0.6	1.4
Systolic Blood Pressure	2.9	14.4	41.2	-6.4	0.2	-0.6	-4.0
Happiness	2.9	3.5	4.9	0.7	2.0	2.2	2.1
Qualifications: A levels/AS levels or equivalent	2.9	6.4	22.4	-4.7	-0.4	-1.1	-1.4
Qualifications: College or University degree	2.9	9.1	34.9	-5.9	-0.8	-0.7	-0.6
Blood Red Count	2.8	26.9	97.0	-9.8	-0.0	-1.0	-3.1
Fluid intelligence score	2.8	5.8	16.1	-4.0	-0.9	-1.4	-2.1
Chronic bronchitis/emphysema (mother)	2.8	3.3	8.9	3.0	-1.2	-0.5	1.6
Medication: Omeprazole	2.7	3.2	8.2	0.9	1.9	2.9	-0.5
Supplements: Zinc	2.6	2.9	5.3	0.5	2.3	2.3	0.9
Noisy workplace	2.6	3.2	5.4	2.3	0.9	1.2	2.3
Current tobacco smoking	2.5	4.1	8.4	2.9	1.3	1.3	2.2
Unable to work because of sickness or disability	2.5	3.3	11.1	3.3	0.4	0.8	1.1
Medication: Lansoprazole	2.4	2.7	8.9	1.2	0.7	-0.0	3.0
Medication: Amlodipine	2.4	3.3	7.1	-0.8	-2.2	-2.7	-0.8
Worry too long after embarrassment	2.4	4.0	9.7	-3.1	-2.0	-1.6	-0.0
Neuroticism (2016)	2.3	3.2	6.1	-2.5	2.2	1.4	-0.2
Schizophrenia (2014)	2.3	5.0	12.6	3.5	0.9	1.2	2.3
Systolic blood pressure, automated reading	2.3	6.6	20.2	-4.5	-0.7	-0.9	-2.2
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.5	8.0	1.7	1.6	2.8	-0.9
Intelligence (Savage-Jansen 2018)	2.2	6.8	15.8	-4.0	-1.2	-2.0	-2.4
Verbal and Numeric Reasoning (VNR)	2.2	5.2	12.5	-3.5	-1.1	-2.0	-1.8
Depression (self-reported)	2.2	2.6	6.9	2.6	0.2	0.6	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.6	7.6	0.6	-0.8	-1.3	-2.8
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.7	6.1	1.8	0.5	1.2	2.5
Supplements: Vitamin C	2.1	2.4	3.3	-0.9	1.8	1.6	1.7
High blood pressure (mother)	2.0	2.9	5.7	-2.4	0.7	-0.0	-2.3
Pulse rate, automated reading	2.0	6.5	16.0	-2.5	-0.9	-1.7	-4.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	4.2	1.6	2.0	1.6	-0.3
Average weekly red wine intake	2.0	3.0	6.0	-2.5	-0.9	-0.3	-2.3
Smoking status: Current	2.0	3.2	7.6	2.7	1.3	1.2	1.5
Irritability	2.0	3.4	5.9	2.3	0.9	1.2	2.4
Smoking Status	1.9	4.6	16.9	4.1	-0.3	-0.6	1.0
Frequency of depressed mood in last 2 weeks	1.9	2.7	5.2	1.2	2.0	2.3	0.2
Medication: Levothyroxine sodium	1.9	3.1	4.9	-1.8	-2.2	-1.6	-1.4
Had other major operations	1.9	2.3	6.1	-1.5	0.9	-0.4	-2.5
Length of working week for main job	1.9	2.1	4.5	-0.5	-1.7	-1.0	-2.1
Comparative height size at age 10	1.9	10.5	39.7	-6.3	-0.8	-1.1	-0.5
Handedness (chirality/laterality): Left-handed	1.9	2.3	2.9	1.4	1.4	1.6	1.7
Pulse wave reflection index	1.8	2.2	3.2	-1.0	-1.8	-1.7	-1.3
Ever highly irritable/argumentative for 2 days	1.8	2.1	3.4	1.6	-1.9	-0.8	1.3
Medication: Allopurinol	1.8	2.4	4.1	0.7	2.0	1.9	1.1
Illnesses of father: Heart disease	1.8	2.5	9.2	-3.0	-0.1	-0.2	-0.9
Hearing difficulty/problems: Yes	1.7	2.6	6.2	1.8	-0.8	0.2	2.5
Pulse wave peak to peak time	1.7	2.1	4.2	0.1	1.8	2.0	0.9
Vascular/heart problems diagnosed by doctor	1.7	4.7	16.0	4.0	-0.3	0.1	1.7
Medication: Metformin	1.6	2.2	4.0	1.5	1.6	2.0	-0.1
Hayfever, allergic rhinitis or eczema	1.6	3.4	6.4	2.4	0.9	0.9	-2.5
Supplements: Glucosamine	1.6	2.0	4.5	0.5	1.5	2.1	-1.1
Financial difficulties in last 2 years	1.6	2.1	3.5	1.8	1.2	1.9	-0.4
Worrier / anxious feelings	1.6	3.1	11.0	-3.3	-0.8	-0.9	-0.1
Pulse wave Arterial Stiffness index	1.6	1.9	3.6	-0.4	-1.8	-1.9	-0.8
Exposure to tobacco smoke outside home	1.6	2.1	5.0	2.2	-0.6	-0.4	-1.7
Mood swings	1.6	2.9	6.2	1.0	2.5	2.0	0.8
Medication: Gliclazide	1.6	1.8	4.9	0.4	0.9	1.2	2.2
Medication: Blood pressure	1.6	3.0	8.8	-3.0	-0.8	-0.8	-1.4
Alcohol drinker status: Previous	1.6	1.8	5.2	2.3	-0.2	0.1	1.4
Schizophrenia vs Biploar Disorder	1.5	2.0	3.3	0.5	-1.8	-1.4	1.5
Ovarian Cancer	1.5	2.0	7.5	-2.7	0.4	0.5	0.1
Chronotype (morning person)	1.5	3.6	7.3	-2.7	-1.9	-1.6	-0.9
High blood pressure	1.5	4.3	13.5	-3.7	-0.1	-0.4	-1.9
Ever unenthusiastic/disinterested for a whole week	1.5	1.9	4.3	1.4	0.2	1.1	2.1
Allergy	1.5	3.5	6.1	-1.9	-1.6	-1.3	2.5
Peak expiratory flow (PEF)	1.5	3.6	9.7	-2.1	-0.4	-0.4	-3.1
Supplements: Calcium	1.5	1.6	4.0	-0.7	1.4	0.3	-2.0
Pack years adult smoking proportion	1.4	2.1	6.7	2.6	0.0	0.3	1.3
Stomach or abdominal pain in last month	1.4	1.8	4.7	0.6	2.2	1.4	-0.3
Time employed in main current job	1.4	1.6	5.5	-2.3	-0.5	-0.4	-0.8
Headache pain in last month	1.4	2.3	4.6	-0.1	-2.1	-2.1	-0.7
Mean time to correctly identify matches	1.4	2.7	7.3	-2.7	0.3	0.1	1.8
Overall health rating	1.4	2.9	4.1	2.0	2.0	1.2	-1.4
Medication: Aspirin	1.4	1.8	4.2	-1.0	2.1	1.2	-0.6
Mineral and other dietary supplements	1.4	1.9	3.3	1.1	-1.2	-1.2	1.8
Alcohol drinker status: Never	1.4	1.7	2.1	-1.2	-1.2	-1.3	1.4
Number of operations (self-reported)	1.4	2.0	6.5	-0.8	-0.3	-0.9	-2.5
Age started oral contraceptive pill	1.4	1.8	6.2	-0.4	-0.6	0.7	2.5
Pack years of smoking	1.4	2.1	6.6	2.6	-0.4	0.1	1.2
Major Depression (MDD)	1.3	1.5	4.6	2.1	1.2	0.3	-0.2
Relative age of first facial hair	1.3	2.6	9.0	3.0	0.5	0.9	0.6
Relative age voice broke	1.3	2.0	6.7	2.6	0.7	1.0	0.1
Mouth/teeth dental problems	1.3	2.0	4.1	-1.8	-0.5	-0.5	-2.0
Number of children fathered	1.3	1.5	5.5	-0.2	-0.0	-0.6	-2.3
Migraine (self-reported)	1.3	1.7	2.4	-0.8	-1.3	-1.4	1.5
Loneliness, isolation	1.3	1.8	3.5	0.3	1.5	1.9	-1.2
Eye problems/disorders: Cataract	1.3	1.5	4.5	-0.5	1.1	2.1	0.2
Illnesses of father: None of the above (group 1)	1.3	1.6	4.1	2.0	-0.1	-0.1	1.5
Ever depressed for a whole week	1.3	1.6	6.2	0.6	-0.0	-0.0	2.5
Bipolar Disorder (2018)	1.2	2.0	3.1	1.7	1.2	1.8	0.4
Cardiovascular Disease	1.2	4.0	14.1	-3.8	-0.5	-0.6	-1.2
Past tobacco smoking	1.2	2.1	5.9	-2.4	-0.5	0.0	1.6
Nervous feelings	1.2	2.3	8.1	-2.8	0.5	0.8	-0.3
Illnesses of mother	1.2	1.5	2.6	0.7	0.6	1.6	1.6
Comparative body size at age 10	1.2	3.3	11.0	3.3	0.1	0.5	1.5
Mouth/teeth dental problems: Loose teeth	1.2	1.5	3.2	0.3	1.8	1.5	0.5
Family relationship satisfaction	1.2	1.4	2.6	0.9	1.6	1.4	-0.4
Risk taking	1.2	1.7	3.0	1.7	0.5	0.9	1.7
Worry (Nagel 2018)	1.1	2.2	8.2	-2.9	-0.2	-0.1	-0.8
Reaction Time	1.1	2.1	6.5	-2.5	0.2	-0.2	1.4
Primary Biliary Cirrhosis	1.1	1.5	3.8	-1.9	-0.5	-0.9	1.1
Hypothyroidism (self reported)	1.1	2.5	6.4	-1.9	-0.5	-0.2	-2.5
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.4	1.3	-0.1	0.8	1.6
Number of incorrect matches in round	1.1	1.8	5.0	1.3	-0.6	0.2	2.2
Lung cancer (father)	1.1	1.2	4.1	2.0	0.2	0.5	0.8
Hypertension (Self-reported)	1.1	3.0	9.2	-3.0	-0.2	-0.3	-1.6
Smoking status: Previous	1.1	1.7	3.6	1.9	-0.0	-0.7	-1.6
Osteoarthritis (self-reported)	1.1	1.5	2.9	-0.5	1.7	0.9	-1.4
Guilty feelings	1.1	1.7	2.7	-1.6	-1.3	-1.4	-0.6
Supplements: Fish oil (including cod liver oil)	1.1	1.4	3.7	-1.2	0.7	0.4	-1.9
Myopia	1.1	1.6	5.3	-2.3	0.3	-0.9	0.2
Fasting Glucose	1.0	1.2	2.3	-0.4	-1.5	-1.0	-1.2
Respiratory disease	1.0	2.2	4.1	0.2	1.5	1.5	-2.0
Angina	1.0	1.3	4.7	-2.2	0.2	-0.1	-0.6
Qualifications: CSEs or equivalent	1.0	1.3	2.0	1.4	-1.0	-0.5	1.4
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.9	1.7	-1.2	-0.8	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	5.3	2.3	-0.4	-0.8	0.4
Medication: Paracetamol	1.0	1.6	3.0	-0.5	-1.7	-1.7	-0.6
Birth weight	1.0	2.1	4.0	2.0	1.3	1.5	0.5
Number of full brothers	1.0	1.2	1.7	-0.4	1.3	1.2	1.2
Angina (self-reported)	1.0	1.3	4.7	-2.2	-0.2	-0.4	-0.5
Friendships satisfaction	1.0	1.2	2.0	0.9	1.4	1.4	0.3
Medication: Aspirin	1.0	1.3	3.1	-1.1	1.8	1.0	-0.3
Average weekly champagne plus white wine intake	1.0	1.4	2.2	-1.2	1.4	1.5	-0.2
Illnesses of father: High blood pressure	1.0	1.3	1.7	-1.2	-1.0	-1.0	-1.3
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.4	0.3	1.1	1.8	-0.2
Pain experienced in last month	1.0	1.7	5.0	-2.2	-0.5	-0.6	1.1
Age at First Birth	0.9	1.3	2.3	-1.4	-1.0	-1.5	-0.3
Coronary Artery Disease (CAD)	0.9	1.1	2.8	-1.7	-0.2	-0.0	-1.2
Ulcerative Colitis	0.9	1.2	3.5	1.9	-0.4	0.2	1.1
Allergy or Eczema	0.9	2.3	4.4	1.9	0.5	0.9	-2.1
Medication: Atenolol	0.9	1.1	2.3	-1.5	1.2	0.7	0.3
Diabetes (self-reported)	0.9	1.4	3.8	1.9	0.7	1.1	0.0
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	3.2	-1.3	-1.2	-1.0	-1.8
Back pain experienced in last month	0.9	1.3	3.4	1.9	0.4	0.4	-1.3
Breast cancer (self-reported)	0.9	1.0	1.8	-0.4	-1.3	-1.2	-0.9
Asthma (self-reported)	0.9	1.8	5.3	0.4	1.2	0.5	-2.3
Heart disease (siblings)	0.9	1.1	3.3	-1.8	-0.3	-0.9	-0.5
Depression (Nagel 2018)	0.8	1.2	1.4	1.2	0.7	1.2	1.1
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.3	1.1	-1.0	-0.6	1.0
Medication: Co-codamol	0.8	1.0	2.3	-0.3	-1.1	-1.5	-0.3
Heart attack	0.8	1.0	2.0	-1.4	-0.7	-1.1	0.3
Pain all over the body in last month	0.8	0.8	1.3	1.2	0.9	1.0	-0.3
Medication: Ramipril	0.8	1.0	2.7	-1.6	-0.0	0.2	-1.1
Alcohol intake versus 10 years previously	0.8	1.2	4.3	2.1	0.0	-0.2	0.6
Falls in the last year	0.8	1.1	2.0	0.6	0.8	1.4	1.2
Asthma	0.8	1.5	4.7	0.6	0.9	0.3	-2.2
Alcohol intake frequency.	0.8	1.8	4.0	2.0	-0.7	0.1	1.6
Medication for cholesterol	0.8	1.2	3.6	1.9	0.0	-0.2	1.0
Alzheimer’s Disease (in father)	0.7	0.8	1.5	-0.1	1.1	0.7	-1.2
Mean Putamen Volume	0.7	0.8	0.9	0.7	-0.9	-0.9	1.0
Blood White Count	0.7	5.4	12.2	-3.5	1.6	-0.1	-2.7
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.3	1.1	1.1	0.9	-0.2
Had menopause	0.7	0.9	2.1	-1.5	-0.9	-0.7	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.2	0.9	-0.7	-0.9	-1.5
Number of live births	0.7	0.9	2.2	0.9	0.5	0.6	-1.5
Medication: Ventolin 100micrograms inhaler	0.7	0.8	1.3	0.7	1.1	0.7	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.2	1.5	0.2	-0.5	1.1
Age at first live birth	0.7	1.2	4.2	-2.0	0.1	0.3	0.7
Age at last live birth	0.7	1.1	4.0	-2.0	0.2	0.5	0.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.5	-1.0	-0.4	-0.9	-1.2
Pain type(s) experienced in last month: Hip pain	0.7	0.9	3.3	1.8	-0.1	-0.3	-0.5
Medication: Paracetamol	0.7	1.2	2.1	-0.4	-1.2	-1.4	-0.9
Medication: Atorvastatin	0.7	0.9	1.6	-1.3	0.3	-0.3	-1.3
Ever smoked	0.7	1.2	4.0	2.0	0.6	0.5	-0.6
Average weekly beer plus cider intake	0.7	1.0	2.1	1.4	-0.7	-0.8	0.9
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.9	-1.4	-0.5	-1.1	0.5
Body Mass Index (BMI) (2010)	0.6	0.8	1.9	0.0	1.1	1.4	0.4
LDL Cholesterol	0.6	1.0	1.6	1.0	-1.3	-1.1	-0.6
Lupus	0.6	0.8	2.6	-0.4	-0.6	-1.6	-0.5
Sensitivity / hurt feelings	0.6	1.1	1.6	-0.9	1.3	1.0	-1.0
Medication for hormone replacement therapy	0.6	0.7	1.4	0.9	0.7	1.2	-0.1
Diabetes (father)	0.6	0.8	1.0	-1.0	0.8	0.7	1.0
Leg fat-free mass (left)	0.6	3.1	4.7	-2.2	-1.3	-1.3	-2.0
Average weekly fortified wine intake	0.6	0.6	2.4	-0.1	-1.5	0.0	0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.3	-0.4	0.4	1.5	-0.0
Serious illness, injury or assault to yourself	0.6	0.7	1.5	0.3	1.2	1.2	-0.2
Sitting height	0.6	4.3	14.9	-3.9	-0.1	-0.0	-1.4
Leg predicted mass (left)	0.6	3.1	4.8	-2.2	-1.2	-1.3	-2.1
Exposure to tobacco smoke at home	0.6	0.6	1.3	0.9	1.1	0.5	0.5
Loud music exposure frequency	0.6	0.7	1.1	1.1	1.1	0.3	-0.5
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.8	1.3	-0.4	-0.7	0.8
Medication for pain relief, constipation, heartburn	0.6	1.0	2.0	1.4	-0.3	0.1	1.3
Neck or shoulder pain in last month	0.6	0.9	1.2	1.1	1.0	0.9	-0.6
Medication: Seretide 50 evohaler	0.6	0.7	2.2	0.0	1.5	0.7	-0.4
Suffer from ‘nerves’	0.6	0.9	2.8	-1.7	0.1	0.4	-0.7
Leg fat-free mass (right)	0.6	3.1	4.8	-2.2	-1.1	-1.3	-2.1
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.8	1.4	-0.7	-0.3	1.2
Leg predicted mass (right)	0.6	3.3	5.2	-2.3	-1.2	-1.4	-2.1
Arm fat mass (left)	0.6	2.3	5.6	-0.7	-1.1	-1.3	-2.4
Fractured/broken bones in last 5 years	0.6	0.7	1.6	-1.3	0.9	0.6	-0.2
Neuroticism (Nagel 2018)	0.5	1.2	4.4	-2.1	-0.1	0.0	-0.5
Alzheimer’s Disease (including proxy)	0.5	0.7	1.8	0.3	0.9	1.3	0.0
Ulcerative Colitis (UC)	0.5	0.9	1.4	1.1	-0.9	0.4	1.2
Height	0.5	10.2	37.0	-6.1	-1.1	-1.6	0.2
Neuroticism	0.5	1.3	4.7	-2.2	0.6	0.2	0.1
Number of treatments/medications taken	0.5	0.9	1.3	-1.1	1.0	0.4	-1.1
Vitamin and mineral supplements	0.5	0.7	1.4	0.2	-0.9	-1.2	0.7
Severe depression (siblings)	0.5	0.5	1.0	-1.0	1.0	0.4	0.1
Impedance of leg (right)	0.5	2.2	3.3	-0.1	1.5	1.8	1.8
Fed-up feelings	0.5	1.0	2.3	0.9	1.5	0.7	-0.5
Multivitamins +/- minerals	0.5	0.7	1.4	0.9	0.1	0.7	-1.2
Waist circumference	0.5	1.9	6.8	0.3	-0.7	-0.6	-2.6
Father’s age at death	0.5	0.7	1.3	1.1	0.6	0.9	0.6
Hair/balding pattern: Pattern 3	0.5	0.8	3.1	-1.8	-0.2	0.0	0.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	4.8	-2.2	-0.7	-0.5	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.2	-0.8	-0.2	-0.7	1.1
Standing height	0.5	5.3	21.1	-4.6	-0.2	-0.0	0.2
Hair/balding pattern: Pattern 4	0.5	1.3	3.2	-1.8	-0.4	-0.6	-1.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.4	-1.6	0.8	-0.2	-0.3
Blood clot in the leg (DVT)	0.5	0.6	1.2	-0.6	-0.5	-0.8	-1.1
Emphysema/chronic bronchitis	0.5	0.6	1.1	0.4	1.1	1.0	-0.3
Number of full sisters	0.5	0.6	1.2	0.6	-1.1	-1.0	-0.0
Chest pain or discomfort	0.5	0.7	1.0	0.6	1.0	0.6	-1.0
Illnesses of siblings: Diabetes	0.5	0.6	1.3	1.1	0.1	1.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.7	-1.6	1.0	0.7	-0.3
Commuting to job workplace: Walk	0.5	0.6	1.6	0.4	0.7	0.1	1.2
Mother’s age at death	0.5	0.6	2.3	-1.5	-0.4	0.1	-0.2
Crohns Disease (2012)	0.4	0.7	2.0	0.8	-0.2	0.2	1.4
Rheumatoid Arthritis	0.4	0.5	1.2	0.2	-0.3	0.8	1.1
Triglycerides	0.4	0.7	1.2	1.1	-0.8	-0.5	0.8
BMI	0.4	2.4	8.5	-1.0	-0.3	-0.4	-2.9
Diabetes (mother)	0.4	0.5	1.1	0.0	0.7	1.0	0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	-0.1	0.9	1.0	-0.1
Body mass index (BMI)	0.4	1.8	6.6	0.5	-0.5	-0.6	-2.6
Impedance of leg (left)	0.4	2.1	3.0	-0.2	1.5	1.7	1.7
Trunk fat mass	0.4	1.6	2.9	-0.7	-1.3	-1.2	-1.7
Forced vital capacity (FVC)	0.4	1.6	4.8	-2.2	-1.0	-0.7	-0.4
Medication: Simvastatin	0.4	0.5	0.8	0.5	-0.7	-0.8	0.9
Neuroticism score	0.4	0.8	1.2	-1.1	0.9	0.8	0.7
Weight	0.4	2.1	5.2	-1.6	-0.6	-0.5	-2.3
Impedance of arm (right)	0.4	1.7	2.5	-1.5	-0.9	-1.2	1.6
Hip circumference	0.4	1.7	3.8	-1.4	-0.5	-0.8	-2.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	5.2	-2.3	-0.3	-0.6	-0.1
Arm fat mass (right)	0.4	1.8	4.4	-0.6	-1.1	-1.1	-2.1
Glaucoma (self-reported)	0.4	0.5	0.8	-0.9	-0.2	0.7	0.8
Gout (self-reported)	0.4	0.6	0.9	-0.4	0.9	0.7	0.9
Forced vital capacity (FVC), Best measure	0.4	1.6	5.5	-2.3	-0.6	-0.5	0.5
Arm fat-free mass (right)	0.4	2.2	5.6	-1.8	0.0	0.4	-2.4
Wheeze or whistling in the chest in last year	0.4	0.7	1.5	1.0	0.5	0.2	-1.2
Eye problems/disorders: None of the above	0.4	0.5	1.0	-0.3	0.8	-0.6	-1.0
Whole body fat mass	0.4	1.6	4.6	-0.6	-0.8	-0.8	-2.2
Arm predicted mass (right)	0.4	1.8	4.4	-1.7	-0.3	0.2	-2.1
Arm fat percentage (left)	0.4	1.7	3.3	-0.3	-1.1	-1.5	-1.8
Diabetes diagnosed by doctor	0.4	0.6	1.8	1.4	0.4	0.7	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.2	-0.4	-1.1	-0.6	-0.2
Qualifications: nursing, teaching	0.4	0.6	2.4	-1.5	0.2	-0.1	-0.2
Osteoporosis (self-reported)	0.4	0.4	0.7	-0.8	0.8	0.1	-0.7
Commuting to job workplace: Public transport	0.4	0.5	1.2	-1.1	-0.1	0.1	-0.9
Basal metabolic rate	0.4	2.1	4.0	-2.0	-0.7	-0.6	-1.9
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.9	-0.9	0.5	0.4	0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.1	-0.5	-0.6	-0.7	-1.1
Alzheimer’s Disease (in mother)	0.3	0.3	1.1	-0.0	0.1	1.1	0.3
Irritable Bowel Disease (IBD)	0.3	0.7	1.3	1.1	-0.8	0.6	0.9
Heel T-Score	0.3	2.1	6.9	2.6	-0.7	-0.5	-0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	0.3	-1.0	-0.5	-0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.7	-0.7	0.1	0.4	-0.8
Trunk fat percentage	0.3	1.3	2.2	-0.4	-1.2	-1.1	-1.5
Taking other prescription medications	0.3	0.4	0.9	0.3	0.7	-0.5	-1.0
Hearing difficulty/problems with background noise	0.3	0.4	1.3	0.1	0.6	1.1	-0.1
Arm fat percentage (right)	0.3	1.3	2.0	-0.1	-1.1	-1.4	-1.3
Pulse rate	0.3	0.5	0.7	-0.8	-0.4	-0.8	-0.8
Impedance of arm (left)	0.3	1.5	2.1	-1.4	-0.9	-1.3	1.2
Birth weight of first child	0.3	0.5	1.0	-0.2	-0.8	0.4	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.5	-0.6	-0.6	-0.5	0.7
Medication: Ibuprofen	0.3	0.4	1.0	-1.0	0.1	0.2	-0.7
Leg fat mass (right)	0.3	1.1	4.3	-0.1	-0.3	-0.2	-2.1
Leg pain on walking	0.3	0.4	1.3	1.1	0.0	0.4	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.6	-0.4	0.8	0.5	-0.8
Knee pain experienced in last month	0.3	0.5	1.6	-0.2	-0.1	-0.5	-1.3
Whole body fat-free mass	0.3	1.8	4.0	-2.0	-0.7	-0.5	-1.6
Long-standing illness, disability or infirmity	0.3	0.4	1.1	-1.0	0.6	-0.4	-0.2
Whole body water mass	0.3	1.9	3.9	-2.0	-0.7	-0.5	-1.7
Wears glasses or contact lenses	0.3	0.4	1.1	-0.2	-0.1	-0.7	-1.0
Ever taken oral contraceptive pill	0.3	0.3	0.7	0.5	0.4	0.1	0.8
Hearing aid user	0.3	0.3	0.5	0.7	0.6	0.6	0.1
Arm fat-free mass (left)	0.3	1.6	3.4	-1.8	-0.3	0.0	-1.7
Commuting to job workplace: Cycle	0.3	0.4	1.0	-0.1	0.6	1.0	-0.4
Leg fat mass (left)	0.3	1.3	5.1	-0.2	-0.3	-0.4	-2.3
Arm predicted mass (left)	0.3	1.7	3.6	-1.9	-0.4	0.0	-1.8
Breast Cancer	0.2	0.6	1.5	0.6	-0.5	-0.5	1.2
HbA1C	0.2	0.3	0.8	-0.1	-0.4	-0.3	0.9
HDL Cholesterol	0.2	0.3	0.7	0.5	0.5	0.9	0.3
Blood Platelet Count	0.2	2.5	5.5	-0.8	2.3	1.8	-0.8
Waist Hip Ratio (WHR)	0.2	1.0	2.7	0.9	-0.4	-0.3	-1.6
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	0.8	0.7	0.6	0.4
Average weekly spirits intake	0.2	0.3	0.5	0.7	-0.7	-0.4	-0.2
Hand grip strength (right)	0.2	0.6	1.5	-1.2	-0.8	-0.4	-0.1
Chronic bronchitis/emphysema (father)	0.2	0.2	0.6	-0.1	0.8	-0.0	0.5
Illnesses of siblings	0.2	0.2	0.9	0.0	-0.2	-0.2	-0.9
Trunk fat-free mass	0.2	1.2	3.3	-1.8	-0.2	-0.0	-1.1
Mouth/teeth dental problems: Dentures	0.2	0.4	1.0	0.3	-0.5	-0.3	1.0
Medication: Cholesterol lowering	0.2	0.3	0.4	0.6	0.4	-0.4	0.6
Prospective memory result	0.2	0.3	0.7	0.4	0.6	0.8	-0.2
Trunk predicted mass	0.2	1.2	3.6	-1.9	-0.2	-0.0	-1.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	0.1	-0.4	0.8	-0.6
Body fat percentage	0.2	0.8	2.2	0.1	-0.7	-0.7	-1.5
Leg fat percentage (right)	0.2	0.9	2.4	0.7	0.4	0.6	-1.5
Shortness of breath walking on level ground	0.2	0.3	0.7	0.5	-0.4	-0.1	-0.9
Medication: Blood pressure	0.2	0.4	1.1	-0.5	-0.4	-1.0	0.2
Had major operations	0.2	0.3	0.5	0.2	0.5	0.6	-0.7
Ever had bowel cancer screening	0.2	0.2	0.4	-0.1	-0.6	-0.5	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.7	-0.8	0.1	-0.5	-0.1
Number of self-reported non-cancer illnesses	0.2	0.3	0.6	-0.5	0.1	-0.6	-0.8
Miserableness	0.2	0.3	0.8	0.3	0.3	-0.4	0.9
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.7	0.9	-0.2	-0.1	-0.1
High cholesterol (Self-reported)	0.2	0.4	1.0	0.2	1.0	0.7	0.3
Medication: Lisinopril	0.2	0.3	0.9	-0.9	0.5	-0.2	-0.4
Leg fat percentage (left)	0.2	0.9	2.8	0.7	0.4	0.4	-1.7
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	-0.5	-0.2	-0.2	-0.8
Depressed Affect (Nagel 2018)	0.1	0.2	0.7	0.1	0.8	0.3	0.1
Crohns Disease (2017)	0.1	0.3	0.8	0.5	-0.9	-0.0	0.4
Prostate Cancer	0.1	0.2	0.4	0.6	-0.3	0.0	0.4
Bipolar Disorder (2011)	0.1	0.1	0.3	0.6	0.0	0.0	0.0
Blood Eosinophil Count	0.1	1.1	3.3	-1.8	0.4	-0.5	-0.8
Lung FEV1/FVC ratio	0.1	0.3	0.6	-0.6	0.8	0.4	0.2
Lung FVC	0.1	0.7	1.8	-0.1	-1.0	0.2	1.3
Tanning	0.1	0.7	2.8	-0.1	-0.1	0.1	1.7
Hand grip strength (left)	0.1	0.3	0.6	-0.1	-0.7	-0.2	0.8
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.3	0.3	0.5	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.4	0.2	0.7	0.3	0.1
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.1	0.5	0.1	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.3	0.6	0.5	0.2	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.3	0.0	0.4	-0.5
Tense / ‘highly strung’	0.1	0.2	0.6	-0.4	-0.2	0.0	0.8
High blood pressure (siblings)	0.1	0.1	0.5	-0.1	0.7	-0.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	-0.6	-0.5	-0.0	0.5
Eye problems/disorders: Glaucoma	0.1	0.1	0.1	0.0	-0.3	0.3	0.3
Cholesterol lowering medication	0.1	0.2	0.7	-0.1	-0.3	-0.1	0.8
Impedance of whole body	0.1	0.7	1.7	-1.1	0.1	-0.1	1.3
Hair Pigment	0.0	0.7	0.9	0.9	0.7	0.7	-1.0
Breastfed as a baby	0.0	0.1	0.1	-0.1	-0.4	0.3	0.1
Commuting to job workplace: Car/motor vehicle	0.0	0.1	0.1	0.3	-0.1	-0.2	0.2

Hub : Genes

TMEM125

Models

Trait associations