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chr3:48,381,826-51,043,528

Best TWAS P=1.36e-12 · Best GWAS P=1.54e-10 conditioned to 0.123

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RNF123	0.14	0.10	blup	324	0.12	4.7e-14	5.2	5.9	4.7e-09	-0.47	0.03	0.97	FALSE
2	GTEx	Adipose Subcutaneous	TCTA	0.05	0.01	enet	10	0.01	5.8e-02	3.9	-5.2	2.3e-07	0.35	0.20	0.07	FALSE
3	GTEx	Adipose Subcutaneous	NICN1	0.20	0.12	lasso	17	0.13	6.7e-11	3.5	-5.2	2.4e-07	0.39	0.99	0.00	FALSE
4	GTEx	Adipose Subcutaneous	RNF123	0.19	0.18	enet	29	0.18	2.1e-14	5.6	5.8	6.0e-09	-0.32	0.03	0.97	FALSE
5	GTEx	Adipose Visceral Omentum	RBM6	0.20	0.28	enet	30	0.30	6.4e-16	-4.9	-5.4	8.3e-08	0.26	0.39	0.61	FALSE
6	GTEx	Adipose Visceral Omentum	RNF123	0.08	0.11	lasso	4	0.07	2.2e-04	5.5	5.6	1.9e-08	-0.30	0.03	0.96	FALSE
7	GTEx	Artery Coronary	RBM6	0.14	0.14	enet	23	0.15	1.0e-05	5.2	-5.7	1.2e-08	0.28	0.04	0.96	FALSE
8	GTEx	Artery Tibial	RNF123	0.08	0.08	enet	12	0.09	2.5e-07	5.6	5.3	1.0e-07	-0.31	0.03	0.97	FALSE
9	GTEx	Artery Tibial	UBA7	0.04	0.03	lasso	4	0.02	7.8e-03	-5.1	-5.5	4.1e-08	0.17	0.05	0.77	FALSE
10	GTEx	Brain Caudate basal ganglia	RBM6	0.20	0.14	enet	16	0.11	5.5e-04	-4.2	-5.5	3.2e-08	0.27	0.20	0.74	TRUE
11	GTEx	Brain Caudate basal ganglia	RNF123	0.13	0.04	enet	20	0.02	1.2e-01	5.5	5.8	6.1e-09	-0.30	0.04	0.87	FALSE
12	GTEx	Brain Cerebellar Hemisphere	RNF123	0.20	0.24	enet	29	0.20	7.7e-06	5.5	5.4	8.4e-08	-0.32	0.03	0.95	FALSE
13	GTEx	Brain Cerebellum	RBM6	0.25	0.41	enet	32	0.33	2.1e-10	-4.9	-5.1	3.0e-07	0.20	0.39	0.61	FALSE
14	GTEx	Brain Cerebellum	RNF123	0.36	0.31	enet	43	0.36	2.4e-11	5.5	6.1	1.1e-09	-0.36	0.03	0.97	FALSE
15	GTEx	Brain Cerebellum	MST1R	0.19	0.24	enet	22	0.20	1.8e-06	-5.0	5.7	1.2e-08	-0.28	0.21	0.78	FALSE
16	GTEx	Brain Cerebellum	FAM212A	0.27	0.35	lasso	5	0.34	9.7e-11	5.5	5.6	2.6e-08	-0.31	0.03	0.97	FALSE
17	GTEx	Brain Cerebellum	GPX1	0.31	0.09	enet	19	0.23	2.0e-07	-5.2	6.0	2.2e-09	-0.49	0.28	0.68	FALSE
18	GTEx	Brain Cortex	RBM6	0.21	0.25	lasso	4	0.29	8.8e-09	-5.1	-5.2	1.6e-07	0.29	0.38	0.60	FALSE
19	GTEx	Brain Cortex	RNF123	0.23	0.05	enet	33	0.04	2.4e-02	5.5	5.2	2.5e-07	-0.34	0.04	0.87	FALSE
20	GTEx	Brain Frontal Cortex BA9	GPX1	0.16	0.06	lasso	6	0.15	7.9e-05	4.2	7.1	1.4e-12	-0.72	0.04	0.86	TRUE
21	GTEx	Brain Nucleus accumbens basal ganglia	RBM6	0.20	0.19	enet	29	0.22	2.0e-06	-4.9	-5.5	3.4e-08	0.34	0.06	0.94	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	USP4	0.08	0.05	lasso	2	0.09	8.7e-04	4.0	5.2	2.2e-07	-0.33	0.26	0.11	FALSE
23	GTEx	Cells Transformed fibroblasts	UBA7	0.07	0.06	enet	5	0.04	7.5e-04	5.5	-5.4	5.4e-08	0.31	0.03	0.96	FALSE
24	GTEx	Colon Sigmoid	RNF123	0.22	0.10	enet	23	0.20	1.1e-07	4.1	5.4	6.4e-08	-0.21	0.06	0.93	FALSE
25	GTEx	Colon Transverse	UBA7	0.28	0.30	lasso	2	0.30	1.1e-14	5.6	-5.6	2.2e-08	0.30	0.03	0.97	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	RBM6	0.25	0.29	lasso	23	0.30	2.2e-11	-4.8	-5.4	6.0e-08	0.25	0.13	0.87	FALSE
27	GTEx	Esophagus Mucosa	RBM6	0.18	0.21	enet	18	0.23	3.0e-15	5.0	-5.3	1.4e-07	0.21	0.36	0.64	FALSE
28	GTEx	Esophagus Mucosa	UBA7	0.04	0.07	enet	8	0.05	4.5e-04	5.6	-5.6	1.8e-08	0.30	0.03	0.96	FALSE
29	GTEx	Esophagus Mucosa	FAM212A	0.19	0.26	enet	24	0.27	4.4e-18	5.6	5.5	3.4e-08	-0.30	0.03	0.97	FALSE
30	GTEx	Esophagus Muscularis	RNF123	0.15	0.14	enet	17	0.14	1.2e-08	5.5	5.5	3.2e-08	-0.30	0.03	0.97	FALSE
31	GTEx	Esophagus Muscularis	MST1R	0.05	0.00	lasso	5	0.05	3.6e-04	-4.9	5.3	1.1e-07	-0.27	0.09	0.74	FALSE
32	GTEx	Esophagus Muscularis	GPX1	0.13	0.05	lasso	14	0.06	1.1e-04	-5.3	6.2	4.2e-10	-0.51	0.56	0.38	FALSE
33	GTEx	Heart Atrial Appendage	RNF123	0.06	0.04	lasso	2	0.02	4.0e-02	5.5	5.9	3.5e-09	-0.40	0.05	0.86	FALSE
34	GTEx	Lung	RNF123	0.13	0.05	enet	18	0.07	5.8e-06	5.5	5.4	5.1e-08	-0.32	0.03	0.96	FALSE
35	GTEx	Lung	GPX1	0.04	0.02	enet	13	0.04	5.7e-04	-5.2	6.7	2.1e-11	-0.50	0.17	0.31	FALSE
36	GTEx	Muscle Skeletal	FAM212A	0.05	0.08	lasso	3	0.07	4.9e-07	-4.6	5.2	1.6e-07	-0.39	0.12	0.87	FALSE
37	GTEx	Nerve Tibial	HYAL1	0.08	0.06	enet	14	0.05	3.6e-04	3.6	5.2	1.7e-07	-0.14	0.26	0.28	FALSE
38	GTEx	Nerve Tibial	RNF123	0.24	0.16	lasso	5	0.15	1.0e-10	5.2	5.5	3.4e-08	-0.31	0.03	0.97	FALSE
39	GTEx	Pituitary	QRICH1	0.28	0.05	lasso	11	0.10	1.5e-03	3.5	5.3	1.2e-07	-0.44	0.18	0.58	FALSE
40	GTEx	Prostate	RBM6	0.14	0.12	enet	15	0.05	1.8e-02	-4.9	-5.2	1.5e-07	0.22	0.16	0.56	FALSE
41	GTEx	Skin Not Sun Exposed Suprapubic	UBA7	0.07	0.03	lasso	6	0.06	2.9e-04	3.7	-5.1	3.1e-07	0.22	0.09	0.87	FALSE
42	GTEx	Skin Sun Exposed Lower leg	RNF123	0.06	0.00	enet	22	0.01	4.6e-02	-4.6	5.7	1.0e-08	-0.34	0.05	0.76	FALSE
43	GTEx	Skin Sun Exposed Lower leg	UBA7	0.04	0.01	lasso	8	0.00	2.9e-01	5.5	-6.0	2.5e-09	0.26	0.04	0.81	FALSE
44	GTEx	Skin Sun Exposed Lower leg	FAM212A	0.05	0.07	enet	16	0.06	1.1e-05	5.6	5.6	2.8e-08	-0.30	0.03	0.97	FALSE
45	GTEx	Spleen	RNF123	0.13	0.13	lasso	5	0.10	1.3e-03	5.5	5.5	3.1e-08	-0.30	0.03	0.85	FALSE
46	GTEx	Spleen	UBA7	0.19	0.14	lasso	22	0.11	8.8e-04	5.5	-5.4	5.2e-08	0.31	0.03	0.93	FALSE
47	GTEx	Stomach	RNF123	0.23	0.12	lasso	15	0.16	4.6e-08	4.1	5.5	3.4e-08	-0.25	0.08	0.92	FALSE
48	GTEx	Thyroid	RNF123	0.09	0.13	lasso	9	0.12	2.7e-09	5.2	5.3	9.7e-08	-0.32	0.03	0.97	FALSE
49	GTEx	Thyroid	MST1R	0.06	0.06	enet	9	0.05	1.7e-04	5.0	5.3	1.5e-07	-0.25	0.08	0.92	FALSE
50	GTEx	Thyroid	UBA7	0.04	0.01	enet	22	0.02	9.2e-03	3.9	-5.1	3.0e-07	0.18	0.13	0.42	FALSE
51	GTEx	Whole Blood	UBA7	0.03	0.04	lasso	2	0.01	1.5e-02	5.6	-5.4	5.7e-08	0.29	0.03	0.93	FALSE
52	METSIM	Adipose	RNF123	0.03	0.02	lasso	12	0.02	2.0e-04	5.4	5.6	1.9e-08	-0.38	0.03	0.96	FALSE
53	NTR	Blood	UBA7	0.02	0.03	lasso	4	0.03	1.6e-09	5.5	-5.6	2.4e-08	0.30	0.03	0.97	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	RNF123	0.04	0.05	lasso	3	0.05	1.4e-06	5.2	5.5	3.9e-08	-0.30	0.03	0.97	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	MST1R	0.02	0.00	blup	278	0.01	4.5e-02	4.8	5.8	6.3e-09	-0.27	0.15	0.78	FALSE
56	YFS	Blood	UBA7	0.16	0.24	lasso	6	0.23	4.0e-75	5.4	-5.4	5.5e-08	0.30	0.04	0.96	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	AMIGO3	0.01	0.00	enet	13	0.01	5.7e-03	4.0	5.7	1.1e-08	-0.38	0.02	0.40	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	UBA7	0.01	0.01	enet	5	0.01	6.6e-04	5.5	-5.7	1.6e-08	0.39	0.01	0.98	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	APEH	0.02	0.02	blup	49	0.02	2.5e-03	-4.8	-5.1	2.8e-07	0.39	0.05	0.65	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UBA7	0.02	0.02	blup	30	0.02	3.8e-03	5.6	-5.5	4.3e-08	0.26	0.01	0.84	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UBA7	0.08	0.09	lasso	5	0.09	3.4e-10	5.5	-5.6	2.8e-08	0.31	0.01	0.99	FALSE
62	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UBA7	0.13	0.16	lasso	6	0.15	1.1e-08	5.5	-5.2	1.5e-07	0.27	0.01	0.99	FALSE
63	The Cancer Genome Atlas	Lung Adenocarcinoma	AMIGO3	0.02	0.00	blup	40	0.00	3.0e-01	5.5	5.9	3.8e-09	-0.30	0.01	0.81	FALSE
64	The Cancer Genome Atlas	Lung Adenocarcinoma	UBA7	0.03	0.04	enet	9	0.02	1.8e-03	5.4	-5.5	4.1e-08	0.31	0.01	0.99	FALSE
65	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GMPPB	0.04	0.02	blup	40	0.02	1.4e-02	5.5	5.8	7.6e-09	-0.29	0.01	0.71	FALSE
66	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UBA7	0.11	0.14	enet	7	0.11	2.7e-05	5.5	-5.4	7.4e-08	0.30	0.01	0.98	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBA7	0.05	0.04	enet	7	0.05	1.6e-05	5.4	-5.5	2.9e-08	0.30	0.01	0.99	FALSE
68	The Cancer Genome Atlas	Stomach Adenocarcinoma	UBA7	0.04	0.05	lasso	1	0.04	1.0e-03	5.5	-5.5	3.7e-08	0.31	0.01	0.95	FALSE
69	The Cancer Genome Atlas	Thyroid Carcinoma	UBA7	0.03	0.01	blup	30	0.02	2.0e-03	5.5	-5.4	5.1e-08	0.26	0.01	0.86	FALSE